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BeSerene™ GABA/theanine cream eases severe muscle tension in her neck/shoulders, prevents her bad headaches and quells her anxiety

October 24, 2025 By Trudy Scott 9 Comments

Hi there… I wanted to add my ‘two cents’ to the discussion about the BeSerene™ GABA/theanine product that you recommend. I LOVE it! I suffer from low GABA levels, which result in my having severe muscle tension in my neck and shoulders. Often, that resulted in bad muscle tension headaches, for which I couldn’t find anything to bring relief. The BeSerene™ GABA/theanine cream has been a real game changer.

If I wake up with one of those headaches in the middle of the night or in the morning, I use two pumps and rub it on my tight neck and shoulder muscles and within 15 minutes, I can feel the tension melting away! It literally goes away! I have even been able to prevent a headache from occurring by using it on my neck muscles before I go to bed at night.

Insofar as anxiety, I get relief from that as well, because generally I start to get anxiety once the headaches start, as I never know if it is going to be manageable with just an ibuprofen or two, or if it is going to be one of ‘those’ headaches, i.e. a migraine that lasts for a day or more! Unfortunately, once the anxiety starts, it makes the muscle tension headache worse, which makes the anxiety worse, and it’s just a horrible vicious cycle!

So, since the BeSerene™ cream works so efficiently on the muscle tension, it quells the anxiety that usually follows!

It has changed my life, and I don’t know of any other product I can say that about. I can honestly say that I will not allow myself to ever be without it now!

Thank you so much Trudy, for recommending this product!

Lisa is a woman in the community who reached out to me via email with this message raving about how life-changing this cream has been for her. I am thrilled for her and never get tired of hearing results like this. I’m not surprised either and love to share these kinds of results! She kindly gave me permission to share, saying “I want others to experience what I have with this product!”

Read on below for more about why she gravitated towards using a cream, other benefits you may expect to see (like a reduction in stress-eating and/or drinking too much wine), my insights into when to consider using a GABA/theanine cream like this and how to use it, where to purchase this exact cream and additional resources if you are new to using GABA.

Why did Lisa gravitate to using a GABA/theanine cream?

Lisa shared that she just couldn’t seem to tolerate the sublingual or oral GABA:

I have tried sublingual GABA products but haven’t had much success, as I haven’t been able to find any without alcohol sugars (xylitol, sorbitol, etc.) Those ingredients give me a terrible taste in my mouth and I just can’t tolerate them. (Why can’t they make one with just real sugar from nature?)

Plus, I haven’t had a lot of success with the oral products as they just take too long to work on the headaches/muscle tension.

I’m really glad she recognized her symptoms were due to low GABA – muscle tension and pain, in conjunction with feeling physically anxious are common. And that she didn’t give up on GABA and persevered until she found what works for her symptoms.

What about other forms of GABA?

However, my advice for someone in Lisa’s situation is not to give up on other GABA products if she finds she needs additional support in the future or finds herself without the cream. With regards to taste and time to work, I recommend a GABA-only (or GABA/theanine) capsule opened on to the tongue or a GABA (and/or theanine) powder – both held on the tongue for 1-2 minutes for quick results.

Stress-eating and self-medication with wine are classic signs of low GABA

Interestingly, stress eating is not an issue for her but wine may be:

I’ve never really had any issues with stress-eating. In fact, I usually have no appetite when I’m stressed out! (That’s where the wine comes in…lol!)

We may self-medicate with wine when GABA is low because it relaxes us physically, helps us fit in socially and feels calming and pleasant. It’s mistakenly used to try and improve sleep but typically makes things worse.

Alcohol consumption damages the gut, depletes B vitamins (especially thiamine/vitamin B1) and zinc – and it’s addicting.

GABA can stop that addiction in its tracks so there are no feelings of deprivation. The reasons we are drawn to GABA are addressed too. And amazingly there is research that GABA may actually heal the gut after alcohol consumption.

Bumping up the GABA/theanine cream may help or considering one of the other GABA products mentioned above may be better.

Low GABA symptoms

As a reminder, if you are new to GABA, it’s an amino acid that helps to address low GABA levels and the associated symptoms: physical tension and feeling anxious, feeling worried or fearful, panic attacks, stiff or tense muscles, insomnia, feeling stressed and burned-out, craving carbs/alcohol for relaxation and calming, intrusive thoughts, spinning/poor focus, fear of heights, rectal spasms, burning mouth, and visceral pain/belly pain with IBS. See the most current list of low GABA symptoms here.

When to consider using a GABA/theanine cream like this?

These are some of the applications I consider

When other GABA products haven’t worked (like in Lisa’s situation)
When looking for something in addition to other GABA products, for example, GABA powder in the day while at work or play, and GABA/theanine cream at night for tension and sleep issues
When there is a specific need for a topical application – like with neck and shoulder tension or belly pain or period pain or leg spasms etc
For an aging parent with Alzheimer’s disease (and sundowning agitation/anxiety)
For a person with ARFID (avoidant-restrictive food intake disorder)
For a person with anorexia or other eating disorder
When a child or young adult has autism (with anxiety and sensorimotor issues), a child/adult who struggles with taking supplements and other special needs children/adults
For someone with multiple sclerosis (for anxiety and muscle spasms/spasticity)
When a person has severe digestive issues and prefers a cream
When someone just wants to take a break from sublingual/oral/powder GABA
For presurgery anxiety since supplements are typically not permitted (even though there is research showing both help)

Where to purchase BeSerene™ IR GABA and theanine cream and how to use it?

This cream can be purchased online with this link (this has my 15% discount built in – you’ll see the discount applied on the checkout page after you add it to the cart).

Purchase BeSerene™ IR

They recommend applying 1-2 pumps to your temples or wrists.

You could also use 1-2 pumps/squirts on your neck and shoulder (like Lisa did), the forearm or inner thigh (before bed for helping improve sleep), and/or belly (especially if belly pain or IBS/SIBO or PMS pain keeps you awake at night). It can also easily be applied if you wake in the night.

Personally, it’s a product I love at bedtime. I apply 2 pumps on my forearm and then rub my belly with any that is left over. It’s calming, improves my sleep and helps with belly pain at night.

I’m sure you can tell by now that this is a product I endorse. I recommend it to clients and to participants in my GABA Quickstart program. In fact, it’s one of the top ten GABA products I recommend and it’s even included in the training materials/handouts of the program!

Additional resources when you are new to using GABA or other amino acids as supplements

We use the symptoms questionnaire to figure out if low GABA (indicating a possible need for GABA or theanine) or low serotonin (indicating a need for tryptophan or 5-HTP) or low endorphins (indicating a possible need for DPA) or other neurotransmitter imbalances may be an issue for you.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings. I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues. The importance of quality animal protein and healthy fats is also covered.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support. We’ll be launching a budget-friendly homestudy version in a few weeks – sign up for the wait list here (the live version with Q&A is offered only a few times a year).

If you also need serotonin support, the Serotonin QuickStart Program is a good place to get help. This is also a paid online/virtual group program where you get my guidance on using tryptophan and 5-HTP safely, and community support during 5 LIVE Q&A calls. You can sign up to be notified when the next live launch of this program is happening.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Now I’d love to hear from you…

I appreciate Lisa’s willingness to share her wonderful results. Now I’d love to hear from you.

Have you used BeSerene™ GABA and theanine cream and how has it helped you?

How does using a GABA/theanine cream compare with other GABA products you have used (feel free to share specific brands and how you used them – sublingual, capsule-opened, liposomal or powder or even another brand of GABA cream)?

As I shared above, some folks prefer a cream only and many use a combination of cream and sublingual.

Feel free to post your questions here too.

Would using 5-HTP or tryptophan help when you crave sugar (as a sort of antidepressant) late afternoon/evening?

June 2, 2023 By Trudy Scott 29 Comments

Would using 5-HTP or tryptophan also help when you crave sugar (as a sort of antidepressant) late afternoon/evening? ~ Kimberley

This question was posed in response to my recent blog post about using tryptophan or 5-HTP to help with alcohol cravings/addiction in the late afternoon/evening – to help you wind down and relax, improve mood and sleep, and also as a reward/treat.

I said yes it is often the same cause when it happens late afternoon/evening and when there are other low serotonin symptoms like low mood, anxiety, worry, insomnia etc. When serotonin is low we self-medicate with wine, sugar, carbs, gluten, dairy and chocolate etc. in order to feel good, get a mood boost and reduce stress. 5-HTP or tryptophan stops the sugar cravings, acts as an antidepressant (improving mood) and eases other low serotonin symptoms too.

It turns out Kimberley was craving sugar late afternoon: “it’s definitely late afternoon for me, while I’m making dinner. Maybe it’s time to go back on 5-HTP.”

And then 2 days later she posted how quickly 5-HTP helped when she added it back mid-afternoon:

I was taking a break from tryptophan/5-HTP and realized after reading this post that that might be a mistake! So I added 5-HTP back in mid-afternoon and my sugar cravings are almost completely gone. It’s funny how I forget the symptoms of low neurotransmitters. Thanks for reminding me!

5-HTP works quickly when it’s low serotonin

How wonderful are these results for Kimberley. I never get tired of hearing feedback like this! I appreciate her sharing and giving me permission to share as a blog so you get to learn and be inspired too.

It’s not unusual for 5-HTP to work this quickly and when it does it’s a clue that the symptoms are related to low serotonin and that she found the ideal dose for her needs.

Kimberley had good results with 5-HTP in the past so she went back to what had worked for her before and it worked for her again.

But do keep in mind, some folks do better with 5-HTP and some do better with tryptophan so it’s a matter of doing a trial of each one each.

50 mg 5-HTP: the sadness and despair lifts in a few minutes

A week later she kindly came and shared additional details in the comments of the tryptophan/ 5-HTP alcohol cravings blog, saying:

It’s possible that I was already in the middle of my daily, mid-afternoon chocolate chip binge when I saw your post

I took a 50 mg 5-HTP along with my mid-afternoon Endorphigen capsule, and within just a few minutes I felt the sadness and despair that I often feel in the late afternoon, start to lift. I was astonished at how quickly it worked! I didn’t open the capsule, or chew it, I just swallowed it with water and had a snack afterwards. I really can’t thank you enough for asking that question because I was really struggling with low mood and sadness almost every day.

Even though KImberley had used 5-HTP with success in the past, she was still astonished how quickly it worked and how effective it was. She was also surprised she had forgotten her prior low serotonin symptoms:

Up until January I had taken 5-HTP in the mid-afternoon and then Tryptophan at bedtime, but I wanted to try a program to support my thyroid. That program told me that too much serotonin is often at the root of gut damage, so I weaned myself off of the 5-HTP and tryptophan. I didn’t really notice much difference, except the daily sugar cravings.

I’m not sure how I could so easily forget the symptoms of low serotonin, but I did.

Your question really was a God-send for me, Trudy. It reminded me that there was an option for feeling better (in fact, MUCH better than sugar makes me feel) that didn’t involve something that’s not good for me.

And I really did feel remarkably better the same day, and those results have continued.

Thanks again, Trudy, for continuing to bring these topics up. Some of us are forgetful and need reminding. Usually, when you have symptoms of low serotonin there are enough other issues going on in your life that it’s easy to overlook the obvious. So I’m very grateful that you asked the question, because I feel so much better able to deal with my circumstances now that I’m back on the 5-HTP. Blessings to you!

I am curious about the program that told her too much serotonin is often at the root of gut damage and if they suggested stopping 5-HTP and tryptophan. It doesn’t make any sense to me. I’ll report back when I learn more about this.

More tired during the day and a headache: what to consider

She did mention “I’m finding myself more tired during the day and have also had a headache for the last few days.” I would suspect chocolate/caffeine withdrawal may have caused her headache.

With feeling more tired I’d also watch the dose of 5-HTP. She may find less is better for her needs.

She is also trying tryptophan at bedtime so that may be making her more tired the next day. Doing one amino acid at a time is often the best way to know how each one is affecting you.

Finding what works for your unique needs

Here are some other amino acid/sugar cravings blog posts that illustrate how we all have unique needs and different biochemical imbalances:

The individual amino acids glutamine, GABA, tryptophan (or 5-HTP), DPA and tyrosine are powerful for eliminating sugar cravings, often within 5 minutes

The individual amino acids glutamine, GABA, tryptophan (or 5-HTP), DPA and tyrosine are powerful for eliminating sugar cravings, often within 5 minutes. It seems that this wonderful benefit – over and above the anxiety-reducing and mood-boosting benefits – is often overlooked or poorly understood.

GABA for ending sugar cravings (and anxiety and insomnia)

For Melissa, an unexpected result was that she stopped craving sugar (chocolates, ice cream and truffles) after about a week of taking GABA for her travel anxiety.

It’s a matter of finding what works for your sugar cravings and unique needs. GABA worked for Melissa and yet 5-HTP works for Kimberley – for their sugar cravings.

Here is the tryptophan/5-HTP alcohol cravings blog that started the discussion: Tryptophan had the added benefit of turning me completely off alcohol when I took it to improve mood and sleep during perimenopause. In this case, tryptophan helped Victoria quit the wine that she was self-medicating with in order to feel good and relax.

Resources if you are new to using amino acids as supplements

If you are new to using amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the symptoms of neurotransmitter imbalances, including low GABA, low serotonin and low endorphins).

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues.

Has 5-HTP helped reduce your cravings and/or feelings of despair and sadness? How much helps and how quickly?

Or do you find tryptophan works better for you? If yes, how much helps and how quickly?

What sugary food/s do you self-medicate with in order to feel good?

If you’re a practitioner, do you use this approach with your clients/patients?

Feel free to post your feedback and questions here in the comments.

Tryptophan had the added benefit of turning me completely off alcohol when I took it to improve mood and sleep during perimenopause

May 12, 2023 By Trudy Scott 33 Comments

I started taking tryptophan 3 years ago to improve mood and sleep (not recognizing I was in perimenopause which it helped), but had the added benefit of turning me completely off alcohol! Lol. What serendipitous timing! I use amino therapy with pretty much all my perimenopause patients now. Thanks to you and Julia Ross’s work. Forever grateful.

Victoria shared this wonderful feedback about the benefits she experienced with tryptophan on a recent Facebook thread and kindly gave me permission to share.

Self-medicating with wine (and other alcoholic beverages) is common when we are anxious or stressed and typically we use it to wind down at the end of the day and to fit in socially. This is common when GABA levels are low and also happens due to low serotonin which declines from mid-afternoon into the evening.

I asked what she had been drinking and how often? And if it was calming for her? This was her response:

Red wine the minute I walked in the door in the evening. I guess it was calming… maybe more reward driven? It would be my reward for getting home from work via picking kids up from sport and doing a grocery shop and … (fill in the blank) that we working mums do and then having to walk straight into the kitchen to start on dinner.

The wine was like my little treat or reward to motivate me to just keep moving with my chores. No time to sit and unwind, just pour the wine and start chopping! Lol… I had tried to stop before but just couldn’t pick up a knife without the wine glass!

Within days, the tryptophan made the wine taste like cat’s pee! Haven’t touched it since. No desire at all. Almost hypnosis like?

How much tryptophan Victoria used and how did it help her quit?

Victoria used the Now Tryptophan 1000 mg at 3pm and 9pm for about a year, eventually stopping it and saying: “Alcohol still does not interest me at all.”

What wonderful results! A typical starting dose for tryptophan is 500 mg midafternoon and evening and she increased this to find her ideal dose of 1000 mg twice a day. She did report that 5-HTP didn’t work for her the way tryptophan did. This is not unusual as some folks do better with one versus the other.

She has a great explanation regarding how tryptophan helped her quit without having to use willpower. She had no time to sit and unwind ….. so she was experiencing some of the calming aspects of getting serotonin support with the amino acid tryptophan. This is a very common benefit.

Serotonin appears to regulate the secretion of beta-endorphins

It is interesting that Victoria mentions a reward/treat benefit which is often due to low endorphins rather than low serotonin. This paper, Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism, states that β-endorphins, in addition to their “potent analgesic effects” i.e. pain relief (both physical and emotional pain), are also involved in “reward-centric and homeostasis-restoring behaviors.”

However, as stated in this same paper, beta-endorphins play a role in stress-relief (common with working moms like Victoria) and are closely connected with serotonin. In fact “serotonin appears to regulate the secretion of β-endorphins” and vice versa. The body is fascinating and so smart.

Amino acids for alcohol addiction: 5-HTP, DLPA and glutamine

We know that amino acids help with alcohol cravings and addiction and have even been used in inpatient settings. This blog illustrates this well – An amino acid supplement with DLPA, glutamine and 5-HTP (and a few other nutrients) eases alcohol withdrawal symptoms at an inpatient detoxification program.

The study authors state that: “the physiological craving for alcohol may be the result of a deficiency of the naturally occurring opiate like substances as well as other neurochemical deficits (i.e., dopaminergic, GABAergic, and serotonergic).

Both tryptophan and 5-HTP support low serotonin worry-type anxiety, low mood and insomnia. Victoria happened to benefit from tryptophan. Someone else may benefit more from 5-HTP or DLPA or glutamine or a combination as illustrated in the above study. And even GABA, which can help with stress-drinking or stress-eating, as well as physical anxiety.

DPA and DLPA support endorphins and provide the reward/treat benefits from red wine that Victoria mentions. You can read about the difference between DPA and DLPA here.

What if you have afternoon and evening sugar cravings instead of wine?

You may self-medicate with sugar, carbs, gluten, dairy instead of wine. Late afternoon/evening cravings are typically related to low serotonin when there are other low serotonin symptoms like low mood, anxiety, ruminations, worry, insomnia, PMS etc. You can see all the low serotonin symptoms here.

In this case, tryptophan or 5-HTP can be used in a similar way to stop the cravings with no willpower required and no feelings of being deprived. You’ll also experience reduced anxiety, improved mood and better sleep. Read more about this on this blog: Would using 5-HTP or tryptophan help when you crave sugar (as a sort of antidepressant) late afternoon/evening?

Other changes Victoria made and how is she doing now?

Victoria did also share that hot flushes “got me in the end though and I gave in to body identical progesterone for the final year of peri” and takes estradiol transdermally now that she is in menopause. Based on seeing these benefits while in perimenopause, she is now trialing tryptophan again for increased irritability. That is a huge plus with amino acids: once we’ve experienced the benefits, you have them at our disposal again and again in the future as your hormones or situation starts to change.

I love that she now uses tryptophan with her patients. She is a physio/physical therapist and exercise scientist turned Functional Health Practitioner having studied with IFM during the pandemic.

Of course, I thanked her for the kind words and shared how fortunate I was to work in Julia Ross’ clinic for 2 years. I also appreciate her for sharing this feedback and allowing me to share it here as a blog post so you get to learn, be inspired and have hope.

And finally, all this illustrates that there is no one-size-fits-all and we often get unexpected side-benefits when using amino acids.

Tryptophan and 5-HTP product options

Victoria happens to respond well to tryptophan and yet some folks do better with 5-HTP so it’s a matter of doing a trial of each.

Products I recommend include Lidtke 500 mg Tryptophan, and Pure Encapsulations 50 mg 5-HTP. You can purchase these from my online store (Fullscript – only available to US customers – use this link to set up an account).

If you’re not in the US, Doctor’s Best L-Tryptophan 500mg and Source Naturals 50 mg 5-HTP are products I recommend on iherb (use this link to save 5%).

Resources if you are new to using amino acids as supplements

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues.

Has tryptophan helped you quit alcohol easily when you could not do so with willpower alone?

Does tryptophan also help with your low mood, anxiety and sleep issues?

What about 5-HTP (some folks do better on one versus the other)?

And has either tryptophan or 5-HTP helped with other afternoon/evening cravings like sugar and other carbs?

If you have questions and other feedback please share it here too.

Tryptophan doesn’t work, then it does and then it doesn’t: could it be hormonal shifts, dietary factors and/or parasites?

November 26, 2021 By Trudy Scott 19 Comments

Have you been in a situation where tryptophan doesn’t work, then it does work, and then sometimes it doesn’t work as expected? There is a reasonable explanation as to why it may not work initially – too much or too little was used. The variable results and the need to switch between lower and higher doses on an ongoing basis can happen but it’s not very pronounced unless there is a specific reason. In this blog I cover some of these reasons – hormone shifts, dietary factors and parasites/other digestive issues.

I’m writing this blog in response to a question that was posted on one of my speaker pages on the Anxiety Summit: Gut-Brain Axis. This is the actual question:

I tried to use tryptophan the first time (whole capsule) and got really high. Some time later I tried again, but used 1/4 of a capsule and had a good result. A few weeks later 1/4 of the capsule didn’t work at night. So I went up to half a capsule. And that’s where I am now. But some nights (very rare) I can only get good results from a whole capsule. I use it along with the same amount of GABA. Is that a normal reaction for tryptophan?

I don’t know what brand of tryptophan she was using but assume 500mg was her starting dose and she now shifts between 125 mg (¼ capsule) and 250 mg (½ capsule) with variable results.

It’s not unusual for someone to not feel great on 500 mg if that dose is too much for their unique needs. She did the right thing by lowering her dose. It’s also reasonable that someone may find 500 mg as an initial dose isn’t enough to reduce symptoms.

The variable results and the need to switch between 125 mg and 250 mg can happen but it’s not very pronounced unless there is a specific reason. Some of these reasons include hormone shifts, dietary factors, parasites/other digestive issues, thyroid issues, low lithium, product quality and environmental factors. More on all this below.

Hormone shifts/more serotonin is needed in the luteal phase

I have my clients track when the variability happens, with female clients documenting their cycles. Some women need more serotonin support in the luteal phase i.e. after ovulation and right up to before their periods. Some may even need additional tryptophan for the first few days of their periods too.

Write about tryptophan working well in the luteal phase in this blog – Tryptophan for PMS: premenstrual dysphoria, mood swings, tension, and irritability

In a study published in 1999, A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria, tryptophan was found to reduce symptoms of PMS when used in the luteal phase or second half of the cycle (i.e. after ovulation):

37 patients with premenstrual dysphoric disorder were treated with L-tryptophan 6 g per day, and 34 were given placebo. The treatments were administered under double-blind conditions for 17 days, from the time of ovulation to the third day of menstruation, during three consecutive menstrual cycles.

They looked at dysphoria, which is defined as a state of unease or generalized dissatisfaction with life, plus mood swings, tension (and anxiety), and irritability and they found a 34.5% reduction of symptoms with tryptophan compared to 10.4% with placebo.

The paper concludes: “that these results suggest that increasing serotonin synthesis during the late luteal phase of the menstrual cycle has a beneficial effect in patients with premenstrual dysphoric disorder.”

It’s a small study but the results are powerful and it’s something I see clinically with my clients. The one big difference is that I typically have clients using tryptophan throughout the month.

But if you are seeing tryptophan work and then not work at similar times each month this is something to consider and track. And then if need be, increase and decrease tryptophan accordingly (and track again).

Dietary factors – collagen, gluten, sugar, wine and coffee

There are other factors to consider too and dietary impacts is one. For example, collagen leads to a higher need for tryptophan in susceptible individuals (due to it’s serotonin-lowering effects – I blog about this here)

Another dietary factor is accidental gluten exposure in susceptible individuals or a newly discovered gluten issue

High sugar intake, alcohol and/or caffeine consumption may also be a factor – contributing to added stress for the adrenals and depletions in zinc and the B vitamins. This can contribute to lowered serotonin and a need for a higher dose of tryptophan.

Now imagine if it’s just before her period and she adds collagen to her diet and she also eats out and gets zapped by gluten. Triple whammy for this woman!

And she goes to a party and happens to indulge in cocktails or wine, and then goes on a binge at the dessert table, followed by a few cups of coffee (or even one dessert and one cup of coffee).

A food-mood log really helps you figure things out. And then, if need be, increase and decrease tryptophan accordingly. And track again and address the dietary issues.

Parasites and other gut issues

If she has a very pronounced shift in symptoms for 4-5 days around a full moon each month – more severe insomnia, more anxious, more depressed – I would want to check for parasites.

I would also want to check for other digestion issues like dysbiosis, SIBO (small intestinal bacterial overgrowth), candida and liver health as they may all be factors. With SIBO and candida, dietary slip-ups may make symptoms worse right after the slip-up, for example increased bloating making sleep and anxiety worse.

Using tryptophan sublingually/opened on the tongue may bypass some of the digestive/liver issues until they are resolved.

As mentioned above, if need be, increase and decrease tryptophan accordingly. And track again and address the underlying issues.

Other factors to rule out – thyroid, lithium, environmental factors and the product

Two other underlying root causes we always want to rule out when we see variable results using tryptophan (and any of the amino acids) are Hashimoto’s thyroiditis (because we can have variable thyroid results – sometimes hypo/low and sometimes hyper/high) and low levels of lithium (because this can affect the results we see with all the amino acids).

And we always check environmental factors like mold, EMFs and outside stresses. And look for infections like Lyme disease or EBV. If the basics are not unearthing the solution we continue to dig deeper and do a full functional medicine workup. And adjust the tryptophan as needed.

And finally the quality of the product is key. I find Lidtke Tryptophan to be better than many other brands. I’ve also had many clients switch to Lidtke tryptophan and see better results and often need a lower dose.

Resources if you are new to using tryptophan and the amino acids as supplements

If you are new to using the amino acids tryptophan/5-HTP and the other amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see the low serotonin symptoms here) and a brief overview here, Anxiety and targeted individual amino acid supplements: a summary.

If you suspect low serotonin or low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids so you are knowledgeable. And be sure to share it with the team you or your loved one is working with.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acid products that I use with my individual clients and those in my group programs.

I always appreciate good questions like this and hope this feedback has helped her and you too if you’ve experienced something like this (or if you do in the future). In case you’re wondering, this question was posted after someone tuned into my interview, “GABA & Tryptophan: Gut-Anxiety Connections” on the Anxiety Summit 5: Gut-Brain Axis.

Have you had a variable response to tryptophan (or 5-HTP) and can you relate to any of this?

What did you figure out to be the reason?

Feel free to ask your questions here too.

Anxiety Summit 6: Toxins/Meds/Infections – Your Roadmap to Finding Your Solutions

October 8, 2020 By Trudy Scott 16 Comments

I’ve created this roadmap for The Anxiety Summit 6: Toxins, Meds & Infections because I want to make it easy for you to get the best value from these wonderful interviews. I don’t want you to feel totally overwhelmed and more stressed when you see all these experts and interview topics and wonder “where am I going to start?”

I’m using the map analogy because as a hiker I know I need a map to be able to find where I’m going and because being out in nature is a big part of the healing process. I’m a visual person and I like to have a clear picture in my mind of the lay of the land BEFORE I set off somewhere new.

It’s for this reason that I’ve created this document with these handy dandy charts that you can refer to at the start of the summit, come back to during the summit and refer to after the summit when you’re re-listening to interviews and reading transcripts.

I hope you enjoy it and find it easier to navigate the summit with these maps:

Root Causes/Triggers – figure out which may be your root causes/triggers
Solutions – for you to explore with the summit interviews
Conditions – see which ones are relevant for you

The numbers in parentheses refer to the number in the cross-reference table at the end – which then gives you the actual talk/s where this topic is discussed.

Here is an example of one of many possible root causes of your anxiety – in the Foods section on the first root causes/triggers map you’ll see: Bone broth, tea, wine and kombucha (fluoride) (17).

These are all surprising sources of fluoride and we talk about these and much more in the interview with Melissa Gallico: “Fluoride: Neurotoxicity, Anxiety, Acne and Hypothyroidism.”

What you’ll learn –

Prenatal fluoride exposure and lower IQ scores in children aged 3 to 4 years
How fluoride can be a trigger for cystic acne, depression, anxiety, Tourette’s, migraines, insomnia and hypothyroidism
Surprising sources of fluoride and protective nutrients

As you know, anxiety can be related to your daily life experiences BUT it can also be triggered by:

foods you eat and what you drink (like wheat, oxalates, alcohol and more)
environmental toxins (like fluoride, lead, plastics, fragrances, insecticides, fluoride and more)
many types of medications (like the benzos/SSRIs, birth control pill, acne medication, fluoroquinolone antibiotics and more) and/or
chronic infections (like Lyme disease, PANDAS, parasites, candida and more).

Once you identify the root causes and understand anxiety’s mechanisms you can support the liver/gallbladder, detox, address infections, implement targeted and supportive solutions, and get relief!

This is my 6th Anxiety Summit, featuring all new topics and the latest research related to anxiety and toxins, medications and infections.

I’d love your feedback in the comments section below

Let us know you find this helpful for navigating the summit
Give us suggestions for improving it and let us know which topics we missed and we’ll do our best to create an updated version
Tell us which aspects of the roadmaps you loved and topics you’d like to learn more about