everywomanover29

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Pectus excavatum and pyroluria: is there a connection?

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Pectus excavatum and pyroluria

I recently received a question about the possible connection between pectus excavatum and pyroluria, a social anxiety condition. In layman’s terms, pectus excavatum is a depression or indentation in the chest wall and is related to problems with connective tissue. This Medscape article describes it as follows:

Pectus excavatum, also known as sunken or funnel chest, is a congenital chest wall deformity in which several ribs and the sternum grow abnormally, producing a concave, or caved-in, appearance in the anterior chest wall.

It’s not something I’m familiar with other than seeing someone with this condition at the beach once (I share some pictures below) and when doing the research for this blog.

The question was posed in relation to a blog on Joint hypermobility / Ehlers-Danlos Syndrome, a connective tissue disorder that does seem to be common in those with pyroluria.

In case you’re new to pyroluria, it is a genetic condition that is frequently associated with a type of anxiety characterized by social anxiety, avoidance of crowds, a feeling of inner tension, and bouts of depression. People with this problem experience varying degrees of anxiety or fear, often starting in childhood, but they usually manage to cover it up and push through. They tend to build their life around one person, become more of a loner over time, have difficulty handling stress or change, and have heightened anxiety symptoms when under more stress. You can read more about it here.

There are also connective tissue symptoms with pyroluria with the following commonly a factor: joints popping, cracking, or aching; pain or discomfort between the shoulder blades; and/or cartilage problems. This is often due to low levels of zinc. Here is the entire pyroluria questionnaire.

Addressing low levels of the mineral zinc and vitamin B6, together with some other nutrients and stress management, are key to addressing pyroluria symptoms. The social anxiety can typically be lifted in a week and the joint and pain problems often ease in 1 to 2 months.

So now that I’ve set things up with an overview of pyroluria and EDS and the connective tissue problems, let me share what I uncovered about pectus excavatum and why I feel there is very likely a connection with pyroluria.

Pectus excavatum and low zinc – impacting connective tissue and psychological impairment

According to this 2012 paper, Pectus excavatum: history, hypotheses and treatment options

Pectus excavatum (PE) … is the most common chest wall deformity, representing 90% of all cases. Depending on the severity of PE, deviations of thoracic organs and spine deformities are known. Although PE in most instances has little or no influence on the function of the inner organs, the cosmetic appearance of the patients leads to psychological impairment which requires therapy.

In the above paper, they write about one of the hypotheses: weak cartilage through metabolism dysfunction. They report decreased levels of zinc in the pectus excavatum patients, suggesting “the lack of zinc in the diet results in a lower metabolic activity of chondrocytes.” Chondrocytes are cells found in cartilage connective tissue. In summary, one hypothesis is that low dietary zinc affects cartilage connective tissue in some individuals with pectus excavatum.

Observe the mention of psychological impairment. Could the low zinc be playing a role in this too? I address this below.

Pectus excavatum and Ehlers-Danlos, plus dental crowding

This paper, Pectus Excavatum and Heritable Disorders of the Connective Tissue, make the connective tissue and Ehlers-Danlos connection:

It seems clear that several patients affected by pectus excavatum display a typical association with connective tissue disorders, which may span from mild form like simple laxity without morbidity associated, to more severe forms such as MFS and Ehlers-Danlos syndrome

This paper also mentions “Highly arched palate with dental crowding” which is common in pyroluria and seems to be related to low levels of zinc.

The image below illustrates a moderate/severe form of pectus excavatum.

pectus excavatum
Figure 1. from Pectus Excavatum and Heritable Disorders of the Connective Tissue

Chest picture of an adolescent affected by a moderate/severe form of pectus excavatum. Written consent was obtained from the patient and the patient’s parents for publication of this image.

Vitamin B6 and high homocysteine

With regards to vitamin B6, one of the other key nutrients needed for pyroluria, one paper, Pectus carinatum repair in an adolescent with hyperhomocysteinaemia: Anaesthetic implications reports a case of a 14-year-old boy with high homocysteine. his level was 18.5 μmol/l (normal levels are within 7–10 μmol/l). He was treated with folic acid, Vitamin B6 and B12 supplements. Is this common in all cases of chest wall deformities? I don’t know but it would interesting to find out.

Pectus excavatum: social anxiety and depression

There are some older studies that report mental health symptoms, including social anxiety are common. In this 1999 paper, Funnel chest. Psychological and psychosomatic aspects in children, youngsters, and young adults, they report these reactions in children older than 11:

embarassment reactions, social anxiety, feelings of stigma, limited capacity for work, orientation towards failure, reduced tolerance of frustration and temptation, limited capacity for communication and even markedly depressive reactions are observed.

It’s understandable that the physical manifestations of this condition would lead to some of these feelings but I have to question how much of this could also be related to low zinc and low vitamin B6. Both nutrients are needed for easing pyroluria/social anxiety symptoms and making neurotransmitters such as serotonin.

Other than trying to make some connections with the research, when this question was asked on facebook, a number of people said they (or a family member) has both pyroluria and pectus excavatum.

If you do have pectus excavatum and pyroluria, getting on the pyroluria protocol will:

  • ease some of the social anxiety and depressive symptoms
  • very likely lead to less pain and discomfort
  • very possibly prevent further connective tissue issues
  • feasibly prevent pectus excavatum in future children or perhaps reduce the severity in the instance where zinc is a factor (this one is a long shot that I feel is worth further research)

I’d love to gather more information and am looking for feedback so please do share your symptoms and experiences in the comments. Let us know if you or your child or other family member has pectus excavatum and any of the following:

  • A score 15 or more on the pyroluria questionnaire and/or suffer from social anxiety
  • Have low zinc
  • Have low B6 (poor dream recall or nightmares is a clue)
  • Have high homocysteine i.e. above 10 μmol/l
  • Ehlers-Danlos syndrome or joint hypermobility
  • Dental crowding

Resources for you

Additional Anxiety Resources
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When using GABA for anxiety does tolerance increase and which amino acid to use for a low mood?

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gaba and tolerence

Today I’m sharing some great questions I’ve received about GABA and serotonin support for anxiety and low mood, and my feedback to give you some ideas on what to look for as you use the amino acids for your own issues (or with clients/patients if you’re a practitioner).

I cover possible reasons for ongoing low GABA levels, long-term use of the amino acids, low mood associated with menopause, problems with mainly sugar- and gluten-free, the role of the adrenals and thyroid, the amino acids I’d start with for low mood, how lithium orotate may help, how to know if collagen is causing a low mood and making you more anxious, and some resources for you.

GABA tolerance has increased

Gaba has been a lifesaver for my anxiety! I also use taurine sometimes for anxiety too, and that has helped too. Right now, I take 1000 mg [of taurine]. As for GABA (I now take 1000 mg of that also) I have noticed that my tolerance for it has increased.

Here is my feedback: I’m really pleased GABA and taurine are helping ease your anxiety. I have not seen tolerance to be a factor with my clients using GABA and I’m not aware of any research on this topic. I would look into what could be depleting GABA at a faster rate so you seem to need more and more.

This could be caused by:

  • increased stress which lowers zinc and increases cortisol
  • poor gut health and dysbiosis (there is a bacteria in the gut that may consume GABA – it’s called gabavorous)
  • low zinc and low B6 (which are needed to make GABA and other neurotransmitters)
  • toxin exposure (we’re now seeing that GABA has a protective effect – this blog covers have GABA is protective of the thyroid after fluoride exposure)
  • thyroid problems (the amino acids are less effective in this instance)

Keep in mind that long-term use of the amino acids is not the plan. Once the diet is addressed and the other underlying biochemistry, nutrient deficiencies, toxins etc. are addressed they should no longer be needed. At most, an occasional “top-up” may be needed.

Low mood associated with menopause

Which amino acids would you recommend for low mood associated with menopause? No panic attacks but a crashing low mood for 24hrs or more before slight recovery, a few easy days and then the cycle begins again. Diet is mainly sugar- and gluten-free. Any suggestions would be appreciated, thank you

Here is my feedback: When I hear “diet is mainly sugar- and gluten-free” with mood swings I always look into gluten exposure and blood sugar dips. Keeping a food mood log is an easy first step to see if the low mood is tied to what is being eaten and when.

I would recommend the complete removal of gluten and sugar. Gluten can trigger depression, anxiety, OCD and lead to many psychiatric symptoms. Blood sugar swings can cause both depression and anxiety. The amino acids make it easy to quite sugar and gluten – no willpower required and no feelings of deprivation. Do the questionnaire and do a trial of the amino acids that apply. Based on the above symptoms I’d suspect tryptophan and tyrosine may help and are always a good first step while everything else is being figured out.

I would also look at adrenal function as they take up the slack in menopause and rule out Hashimoto’s thyroiditis and Graves (as you can get mood swings with both as the thyroid levels shift).

Low lithium can also cause mood swings too and lithium orotate can help to keep an even mood, allowing the amino acids to be more effective.

Finally, I’d want to know if collagen, gelatin or bone broths have recently been added to your diet and are being consumed in an on-an-off pattern that correlates with the low mood. Certain susceptible individuals find that it lowers serotonin and increases depression and anxiety, and causes insomnia.

Next steps are a full workup looking at sex hormones, low zinc, low B6, low magnesium, the gut, EMFs, sleep and other dietary factors like salicylates, histamine, glutamates etc. We look at all the possible 60+ nutritional and biochemical root causes and address them or rule them out.

It’s also important to have a good support system in place for those very low days – friends and family members, being part of a community and even keeping a mental health support line number close at hand.

And of course, I always say this: get out in nature, get some exercise, hug someone and have a good laugh.

Resources for you

  • My book The Antianxiety Food Solution (my Amazon affiliate link) has an entire chapter on the amino acids GABA, tryptophan, tyrosine, and DPA (and how to use them), a chapter on blood sugar balancing and glutamine and a chapter on gluten issues (and much more). Read it and become a savvy health-advocate for yourself. Become someone who is well-informed about the amino acids, the precautions and nuances, and all the nutritional approaches for anxiety-relief. Share a copy with your doctor and point out the references.
  • If figuring it out alone or reading my book feels overwhelming to you, or you’re afraid to use the amino acids on your own, my home-study Amazing Aminos for Anxiety program walks you through a step-by step approach on how to figure out which symptoms are tied to which neurotransmitter deficiency, and how to trial each respective amino acid. Stay tuned for a special upcoming launch with live Q and A calls so you can get your questions answered. (If you have recently purchased the homestudy ONLY version we will be contacting you to invite you to participate.)
  • Here is a blog to read if you’re new to GABA: GABA for the physical-tension and stiff-and-tense-muscles type of anxiety
  • Here is a blog to read if you’re new to tryptophan: Tryptophan for the worry-in-your-head and ruminating type of anxiety (it’s a blog about low serotonin anxiety but applies to low-serotonin low mood too)
  • Here is a blog to read if you’re new to tyrosine: Tyrosine for focus, motivation, energy, a good mood and possibly even anxiety
  • You can find the amino acids in my supplement store here.

Can you relate to either of these questions? And are you good at playing a detective to figure out why something may not be working as expected?

What has worked for your anxiety and/or low moods?

Feel free to post questions in the comments too.

And let me know if you’re interested in the homestudy program with live Q and A calls. (If you have recently purchased the homestudy ONLY version we will be contacting you to invite you to participate.)

Additional Anxiety Resources
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The Toxin Solution – an interview with author Dr. Joseph Pizzorno

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toxin solution

Toxin exposure is at an all-time high and very relevant when it comes to anxiety, ADHD, asthma, diabetes, cancer, dementia and all chronic diseases. I did this wonderful interview with Dr. Joseph Pizzorno in 2017 when his book – The Toxin Solution – was published and for some reason it didn’t make it onto the blog.

I’ve decided to share it now because Dr. Pizzorno is one of the speakers at the August IMMH/Integrative Medicine for Mental Health conference.

If you’re planning to attend this will give you a taste of what to expect. If you’re on the fence hopefully this will convince you, together with the fact that I’m presenting again this year (I’m doing a deep dive into GABA).

I look forward to meeting him in person at the conference and will hopefully see you there too! If you can’t make it or are not a practitioner enjoy this interview and do checkout his fabulous book.

Read on for notes from our interview, the video interview and resources for you related to our interview. Some highlights include these facts: about 90% of diabetes is just due to 6 toxins; PCBs (polychlorinated biphenyls) may account for half of all breast cancer; top 10% of those exposed to organophosphate pesticides saw a doubling of ADHD (just one pesticide); 20% of osteoporosis in women is due to cadmium; lentil soup in a can has 10 x more BPA than homemade and much more

Here is the book: The Toxin Solution: How Hidden Poisons in the Air, Water, Food, and Products We Use Are Destroying Our Health–AND WHAT WE CAN DO TO FIX IT (my Amazon link)

Here is our wonderful interview

And here is a summary from the video interview:

  • in mid to late-70s people were sick because of nutritional deficiencies, lack of exercise and lifestyle factors
  • we have polluted our air, water, food, health and beauty aids, household cleaning products, products in our yards – independent of what you do, toxins are coming in
  • he worked with big oil company in Canada – they wanted to improve the health of the staff and he ran tests to measure nutritional status and toxin levels ($1500 worth of lab tests of 4500 people) – saw a lot of toxicity
  • top 20% of those with body burden of toxins vs bottom 20% – what is disease risk? very big increase in disease risk
  • diabetes as example – when he was in medical school 50 years ago diabetes affected 1% of the population and now it’s 20-30x more common
  • looked at data on diabetes and toxins – looked at organochlorine pesticides – used widely in our food supply
  • top 10% of those with high body burden – 12 fold increase risk of diabetes
  • looked at many other diseases and all had high correlation of toxicity with higher risk
  • used his book advance to hire researchers (Bastyr grads) to determine what toxins contribute to what diseases
  • about 90% of diabetes is just due to 6 toxins
  • it’s why he wrote this book The Toxin Solution (my Amazon link) – here’s how toxins cause disease, here’s where the toxins are coming from, here’s how you avoid them and here’s how you prepare your body for a detox (do this first) and then do the detox
  • [I shared my exposure to lead when I worked in an oil refinery before I became a nutritionist]
  • oil field workers he tested were never exposed to the oil itself as it was underground – they were also farmers and spaying with pesticides, herbicides and insecticides
  • everyone can relate to how dangerous smoking is i.e. lung cancer is doubled by smoking and it affects 20-25% of the population, so bring it home for people asked if there are other toxins that increase the risk of certain diseases – answer is most certainly yes
  • asthma – Polycyclic aromatic hydrocarbons (PAHs) from second-hand smoke, city living, diesel, barbecue smoke; 93% of the US population have enough PAH exposure to double their risk of asthma
  • breast cancer – PCBs (polychlorinated biphenyls) may account for half of all breast cancer
  • some data on toxins and anxiety, mental health but more on neurodegeneration and dementia; damage to the neurons will make you more prone to anxiety, stress and depression
  • anxiety and ADHD in children – top 10% of those exposed to organophosphate pesticides compared to bottom 10%, saw a doubling of ADHD (and this was just looking at one pesticide)
  • neurological system is really susceptible to these toxins
  • if you’re eating conventional foods you’re full of toxins
  • Seattle study on kids coming out of organic stores vs those coming out of conventional stores – the later had 10x higher levels of organophosphate pesticides
  • high phosphate fertilizers are contaminated with cadmium
  • osteoporosis study in women – thinner bones when exposed to cadmium from conventional soybeans; 20% of osteoporosis in women in the USA is due to cadmium
  • eat organically grown foods
  • foods will absorb BPA and phthalates from the cans they are in
  • study comparing homemade lentil soup vs lentil soup in a can – canned lentil soup had 10 x more BPA
  • BPA binds to insulin-receptor sites, pancreas burns out and you get diabetes
  • [I mention moms exposed to BPA when pregnant and their children have higher risk for ADHD and anxiety]
  • children born to moms in top 10% of exposure to organophosphate pesticides vs bottom 10% – children had a 7 point drop in IQ (even when followed for 7 years)
  • women who breastfeed have lower cancer risk and more breastfeeding leads to lower PCB levels (breast-feeding for 12 months decreased PCB levels by 40%)
  • great for the mom but no good for the children
  • what’s remarkable – PCBs were banned in the US 40 years ago – so hard to breakdown in our bodies and the environment so they accumulate
  • best plan – east organic, don’t use plastic storage containers, beauty products with no phthalates
  • check your water – in the USA 10% of public water has high enough arsenic levels to increase risk of diseases; at least use carbon filter to get out the chemicals
  • 60-70% of out toxin exposure comes from food – we have control over this and the body can heal
  • [I say the book offers solutions: The Toxin Solution: How Hidden Poisons in the Air, Water, Food, and Products We Use Are Destroying Our Health–AND WHAT WE CAN DO TO FIX IT (my Amazon link)]
  • our bodies evolved to detoxify and there is a lot we can do
  • what to do – don’t let them in
  • increase your fiber intake – liver denatures toxins by binding them to another molecule and dumps them into the gut where they are bound to fiber and excreted but 90% of toxins get reabsorbed through enterohepatic circulation because we now only consume 15-20g of fiber a day. You need at least 40-50g of fiber a day to detox
  • if you do nothing more than consume more fiber you will get the toxins out – it’s very slow but you will get the toxins out
  • flax seeds, oats, alginate, pectin
  • not a fan of wheat fiber – most of his patients don’t tolerate wheat
  • any kind of fiber that mixes in water and gels – this is good
  • NAC (N-acetyl cysteine) – the cysteine promotes the production of glutathione (most important intracellular and intra-mitochondrial antioxidant
  • glutathione is also part of process in the liver where it binds chemical toxins in order to neutralize them and dump them into the gut to get rid of them
  • as little 500mg/day of NAC can help your body get rid of toxins
  • next is sweat – saunas and running, but not steam-baths as this recirculates stuff – your sweat is full of toxins
  • [I have a question about the toxin-filled sweat on the towels and in the sauna]
  • air out the sauna and wash the towels but it’s not ideal because then we’re putting those toxins back into the environment (can burn them or bury them but there is no good solution) – best to stop putting chemicals into environment
  • [I have a question about an indoor saunas and toxins going into the home]
  • valid question – his sauna has a window to the outside
  • tip for homemade cleaning products – water, vinegar and lavender oil (which is both calming and antibacterial)
  • no to fragrances which are solubilized to phthalates and 1/3 of all diabetes is linked to phthalate exposure
  • you get exposed to phthalates when hot water hits your plastic shower curtain
  • great-grandfather ate a Mediterranean diet lived to 95 and never saw a doctor, grandfather ate a mix of American diet and Mediterranean diet
  • dad ate 100% American diet, plus not worried about exposure to chemicals – lived to 88 but had dementia by 83, osteoporosis, arthritis, hip replacement surgery, cardiac surgery
  • final words of wisdom: good health is quite straight-forward – eat real food rich in nutrients and avoid toxins as much as you can and your wonderful body will take of just about everything else

Resources for you

Do let us know what steps you’ve made to reduce toxic exposure in your life and what you’ve done to detox, and what improvements you’ve observed.

Feel free to post questions in the comments too.

And let me know if you’ll be at IMMH. And be sure to stop by and say hi to both me and Dr. Pizzorno.

Additional Anxiety Resources
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Sjogren’s syndrome: tryptophan and GABA for anxiety, and moisturizing for dry skin and inflammation?

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sjogren's syndrome

A few weeks ago I blogged about a new pilot study about the use of a skin moisturizer twice a day reduced inflammation in older adults. I use the inflammation research to question if this may be applicable and helpful for you if you suffer from anxiety, extrapolating that it may well be given the added benefits of touch and an oxytocin boost.

I received a number of great questions about how to apply this information and have decided to share a question from someone with both Sjogren’s syndrome and anxiety, in order to illustrate how I’d work with someone like this.

Here is the question I received:

I would like to know how much of one’s body needs to be moisturized, and if it is also necessary to be done twice per day? Such a simple but effective way to help with anxiety. Will be slathering a lot more in the future! I have Sjogren’s so everything is dry – skin, mouth, eyes, hair. I have been trying to keep my face much “moister” and I am sure my wrinkles have lessened. I find rice bran oil is also quite good.

I’m going to address her moisturizing question below and share more about anxiety in Sjogren’s syndrome and some nutritional solutions, but first let me explain what Sjogren’s syndrome is.

An overview of Sjogren’s syndrome

Let me explain what Sjogren’s (SHOW-grins) is in case you’re not familiar with this condition. It’s an autoimmune condition and is described as follows on the Mayo Clinic site:

often accompanies other immune system disorders, such as rheumatoid arthritis and lupus. In Sjogren’s syndrome, the mucous membranes and moisture-secreting glands of your eyes and mouth are usually affected first — resulting in decreased tears and saliva.

Although you can develop Sjogren’s syndrome at any age, most people are older than 40 at the time of diagnosis. The condition is much more common in women.

The site goes on to say that other than dry eyes and mouth, some people experience joint pain and stiffness, swollen salivary glands, skin rashes or dry skin, vaginal dryness, persistent dry cough and prolonged fatigue. It’s worth a read to learn more about complications like more dental cavities, yeast infections, vision issues, problems in the lungs, kidneys or liver, the risk of lymphoma and peripheral neuropathy.

My feedback about moisturizing

In the study, moisturizing was done twice a day. I’m not sure how much of the body needs to be moisturized but if everything is dry, I’d want to moisturize as much as possible.

Given that chronic inflammation is a major factor in Sjogren’s and other autoimmune conditions like systemic lupus erythematosus, it’s feasible to expect similar benefits in terms of reduced inflammation. Hopefully we’ll see research on autoimmune conditions in the future.

When it comes to anxiety, I do want to make it clear that I was and still am extrapolating from the research on inflammation and measuring reduced anxiety was not part of the study. Moisturizing may or may not help with anxiety and I certainly wouldn’t only use this intervention.

Anxiety in Sjogren’s – low serotonin and GABA?

You may not be aware that anxiety/depression is very common in Sjogren’s. In one study they

found 33.8% patients with anxiety, and 36.9% had depression, which were significantly higher than controls.

I use a comprehensive nutritional and lifestyle approach to help my clients ease their anxiety and as I mention above, I would not only rely on moisturizing.

I would use the serotonin questionnaire to determine if low serotonin is contributing to the anxiety (the worry-in-the head and rumination type of anxiety) and do a trial of tryptophan or 5-HTP.

Interestingly, a number of studies suggest the involvement of the serotonin system in the development of Sjogren’s, with one study reporting

Significantly lower platelet levels of serotonin in Sjogren’s patients as compared to healthy controls.

They didn’t find a correlation between the levels of serotonin and how severe the Sjogren’s symptoms were, which falls in line with what we know about biochemical individuality and why doing a trial of tryptophan or 5-HTP (to find your ideal dose) is the best approach for serotonin support.

I would use also the GABA questionnaire to determine if low GABA (physical tension type of anxiety) is a factor, and do a trial of GABA.

If you recall, in the Mayo Clinic description above, stiffness is a common symptom of Sjogren’s and GABA eases stiffness.

I haven’t found any research on GABA in Sjogren’s, but one case study reports that a patient experiencing athetoid movements (a movement dysfunction, characterized by involuntary writhing movements), reported symptom improvement with hydroxychloroquine, pilocarpine, gabapentin, and clonazepam. The latter two medications work on the GABA system.

You can find the tryptophan and GABA products I use with my clients here.

Poor sociability in Sjogrens – could this be related to pyroluria?

A study published earlier this year is reportedly the first study to conclude that patients with Sjogren’s score “high on neuroticism and anxiety and low on sociability.”

If social anxiety is a concern, I’d have her do the pyroluria questionnaire and address this if needed.

If you recall, in the Mayo Clinic description above, joint pain and dental cavities are common symptoms. These are also very common with pyroluria, so using a nutritional approach helps ease the social anxiety, and improves joint issues and mouth health.

The other factor that makes me suspect pyroluria may be common in Sjogren’s is that it’s considered a systemic connective tissue disorder, together with systemic lupus erythematosus and rheumatoid arthritis. You can read more about pyroluria and connective tissue disorders on the pyroluria prevalence blog and the Ehlers Danlos/joint hypermobility blog.

Poor mouth health is also common with histapenia/low histamine so I’d want to look into this too.

You can find the pyroluria supplements I use with my clients here.

Sjogren’s and the Autoimmune-Paleo diet

Since Sjogren’s is an autoimmune condition, following an Autoimmune-Paleo (AIP) diet is key too. Here are some books that are well-worth making part of your library, even though they are not specific to Sjogren’s syndrome they offer support for autoimmune conditions (and many individuals often have more than one autoimmune disease)

Here is one more resource for you: The Autoimmune Masterclass which airs online this weekend It’s a similar format to online 7-day summits but runs for 2 days instead and is no-cost to attend during these two days.

I haven’t dived into the research on all the other autoimmune conditions and the above connections (low serotonin, low GABA and pyroluria) but it’s highly likely similar connections exist. So, if you have any autoimmune condition and anxiety this could all apply for you too.

If you have been diagnosed with Sjogren’s syndrome please share if GABA and tryptophan have helped ease your anxiety, and if the pyroluria protocol has helped you with social anxiety?

And let us know if moisturizing is helping your dry skin and possibly reducing inflammation and anxiety too?

Additional Anxiety Resources
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DIY moisturizer recipes to lower inflammation and reduce anxiety, panic, PTSD, phobias and social anxiety?

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Could daily use of a good quality moisturizer help to reduce anxiety, panic, PTSD, phobias and social anxiety by reducing inflammation? Last week I blogged about a new pilot study on how a skin moisturizer reduced inflammation in older adults and extrapolated these results suggesting this may well be applicable for you if you suffer from anxiety because of the reduced inflammation. The benefits of touch, the oxytocin boost and slowing down for some self-care most likely play a role too. I promised to share some DIY home-made moisturizer recipes so here goes. You’ll see that many of these include ingredients that are helpful for anxiety when used stand-alone, so you get that benefit too.

Dr. Mariza shares Lavender-Cocoa Body Lotion Bars and a Soothing Skin Roller Blend

Dr. Mariza Snyder, author of The Essential Oils Hormone Solution (my Amazon link) and Smart Mom’s Guide to Essential Oils (my Amazon link), has a lovely recipe for DIY lotion bars on her site which she gave me permission to share here. She describes these bars as a “luxurious chocolaty-lavender post-shave moisturizer.” She adds that “Lavender and Geranium essential oils are the perfect combination when it comes to softening the skin while helping you to relax in the process.”

Lavender-Cocoa Body Lotion Bars

Ingredients:

1 cup beeswax pastilles
1 cup cocoa butter
1 cup coconut oil
2 teaspoons vitamin E
10 drops lavender essential oil
10 drops geranium essential oil

Directions: Combine all ingredients except essential oils in a double boiler or a glass bowl over a smaller sauce pan with 1 inch of water in it. Bring to a boil. Stir ingredients until they are completely melted and smooth. Remove from heat and then add essential oils and stir. Pour mixture into silicone bake cup molds for the lotion to solidify, allowing them to completely dry before removing them from the molds. Store lotion bars in a clean container and apply to body after a shower. The heat from your body will melt the lotion! Yield: 10-12 bars (depending on molds).

Check out her blog for other self-care recipes like a salt scrub, a cooling peppermint shaving cream and a razor burn serum (with versions for both women and men).

When I reached out to her for recipes, Dr. Mariza also shared a soothing skin healing blend recipe saying: “I’ve used this blend to reduce inflammation and redness on irritated skin with incredible success! I’ve treated a lot of acute eczema and psoriasis with this blend flare ups.” 

Soothing Skin Roller Blend 

Ingredients:

5 drops Melaleuca/Tea Tree essential oil
5 drops Geranium essential oil
6 drops Rose essential oil (optional)
6 drops Lavender essential oil
6 drops Frankincense essential oil
Fractionated Coconut Oil or Carrier Oil of choice

Directions:  Add essential oils to 10ml roller bottle and top off with Fractionated Coconut oil, or carrier oil of your choice.  Apply directly over the area of concern to reduce red, irritated skin.  Use as needed.

You can read my review of her book here): The Essential Oils Hormone Solution.

Dr. Z and Mama Z share their most used recipe: DIY Healing Skin Serum

Dr. Eric Zielinski, author of The Healing Power of Essential Oils (my Amazon link), and known affectionately as Dr. Z, and his wonderful wife, Mama Z, gave me permission to share this DIY Healing Skin Serum recipe. They run the Natural Living Family site.

Mama Z’s DIY Healing Skin Serum

Ingredients:

1 tablespoon cold fresh frozen aloe, or aloe vera gel
1 tablespoon organic coconut oil (softened or melted)
5 drops lavender essential oil
2 drops frankincense essential oil

Directions:

  1. Blend the aloe gel, coconut oil and essential oils in a Magic Bullet or food processor until smooth.
  2. Once well mixed, store in a class jar or glass salve container in a cool place so the coconut oil remains hardened.
  3. Store in fridge or cool place and enjoy at least once per day. Make fresh each week.

Notes: No matter what allergies you may have, there’s a carrier oil that’s right for you. You can use any, or a combination of these: Avocado, Fractionated Coconut, Grapeseed, Jojoba, Sweet Almond.

Be sure to read the entire blog post to get the back story on how Mama Z used this to heal her face after experiencing some chemical burns from store bought facial cleansers and creams when she was a teen, how it helped her dad with some skin cancer on his hands, some tips on aloe and some recipe variations.

Dr. Z gives it this glowing endorsement: “This is by far the most proven and most used DIY recipe that we have. It helps people with everything with skin cancer to sun burn, eczema to acne to psoriasis to you name it.”

Here is my review of Dr. Z’s book: The Healing Power of Essential Oils. You’ll find additional recipes here.

If you’re looking to learn how to use essential oils, I highly recommend their Essential Oils for Abundant Living 10-Part Video Masterclass.

Rachael, herbal skincare formulator, shares a lovely Skin Repair Souffle recipe

Rachael Pontillo, Licensed Aesthetician, herbal skincare formulator, educator and author of Love Your Skin, Love Yourself (my Amazon link) shares this lovely Skin Repair Souffle recipe.

Skin Repair Souffle Recipe

Supplies needed:

A glass jar–4 oz is preferred
A small double boiler/bain marie
Heat element (stove, cooktop, hot plate)
Kitchen scale
A small whisk
Small hand mixer, milk frother, or immersion blender

Ingredients:

30 g shea butter
30 g jojoba oil
15 drops total essential oils (Frankincense, Helichrysum, Geranium, and Lavender are the essential oils Rachael likes best for barrier support. She says either choose one or create a blend).

Instructions:

  1. Heat your double boiler until the water is boiling, then reduce to a simmer.
  2. Add the shea and jojoba and whisk gently until completely melted.
  3. Remove the vessel from the heat (careful not to get water into the mixture), and cool to room temperature in an ice bath while stirring gently.
  4. Add your essential oils, one by one, stirring gently.
  5. Blend gently with your milk frother or blender until the mixture begins to rise with a meringue-like texture (usually about 60 seconds)
  6. Pour into your jar. Close the jar immediately. Refrigerate overnight.

Dr. Keira, The Skin Whisperer, shares Lavender Bath Oil and Rejuvenating Serum

Dr. Keira L. Barr, MD, Founder and Chief Wellness Officer of Resilient Health Institute and author of The Skin Whisperer: A Dermatologist Reveals How to Look Younger, Radiate Beauty and Create the Life you Crave (my Amazon link), shares two wonderful recipes.

Lavender Bath Oil

Ingredients:

30 ml Almond Oil (or other carrier oil)
3 drops lavender essential oil
1 drop jasmine essential oil
1 drop myrrh essential oil

Instructions:

Mix all oils together in a bottle and shake well. This oil can be applied to skin in the shower, added to bath water or used after bathing or showering (while skin is damp but not completely dry to aid in absorption). Note: essential oil is 1% dilution.

Rejuvenating Serum 

Ingredients:

4ml Rosehip Seed Oil
3 ml Argan Oil
1 ml Pomegranate seed Oil
1 ml Sea Buckthorn Oil
1 drop carrot seed essential oil
Pour into 10 ml amber or dark colored glass bottle and label

Instructions:

Blend all the oils together adding the carrot seed essential oil last. Shake thoroughly and store in the refrigerator. Apply 3 to 5 drops after cleansing the skin nightly. Can be used on the face, neck and back of hands.

Calming essential oils and the original blog

As I mentioned above many of these recipes include ingredients that are calming and helpful for anxiety when used stand-alone, so you get that benefit too:

If you missed the original blog with the research or would like a recap here it is: Could a daily moisturizer help to lower markers of inflammation and reduce anxiety, panic, PTSD, phobias and social anxiety?

You can learn more about the study; why poor skin health leads to inflammation; the role of inflammation on anxiety and other mental health conditions; the many nutritional approaches for reducing cytokines and inflammation; some studies on the benefit of touch and a boost of oxytocin; and tips for adding skin moisturizing to your daily self-care routine.

Skin moisturizing, diet and calming nutrients

As I said in the original blog, I feel very comfortable saying you now have a new tool – daily skin moisturizing – to add to your toolbox to help lower inflammation and reduce anxiety, panic, PTSD, phobias and social anxiety. Let’s use this – together with dietary changes and key calming nutrients – to eliminate anxiety and feel your absolute best.

These recipes provide safe and fun options for you to try. Have fun with these recipes and be sure to share which ones you try and like or if you have your own favorite. Also share what your moisturizing self-care routine is like.

I have more to share – all the feedback from a recent Facebook post on favorite home-made and store-bought moisturizers and will share this in the next installment. Do let me know what else you’d like me to cover.

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Could a daily moisturizer help to lower markers of inflammation and reduce anxiety, panic, PTSD, phobias and social anxiety?

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Could using a good quality moisturizer on a daily basis help to lower markers of inflammation (proinflammatory markers) and actually help reduce anxiety, panic, PTSD, phobias, social anxiety and other mental health symptoms, plus other chronic health conditions at the same time? Based on a new pilot study, I’m going out on a limb and saying this may well pan out to be true. And there is certainly no harm in making this a daily self-care routine until further research confirms this, certainly because of the other benefits of using a moisturizer.

New study: a skin moisturizer reduces markers of inflammation

Let’s take a look at this new study which reports how using a skin moisturizer actually reduces markers of inflammation in the body: Topical Applications of an Emollient Reduce Circulating Pro-Inflammatory Cytokine Levels in Chronically Aged Humans: A Pilot Clinical Study

Emollients are moisturizers that help keep the skin moist and supple by reducing water loss from the epidermis, the outer layer of the skin.

The study set out to mirror an animal study where skin problems in older/aged mice was tied to elevated markers of inflammation called cytokines. When epidermal function/skin health in the mice was improved, the circulating cytokine levels were reduced:

Thirty‐three aged humans were treated twice‐daily for 30 days, with ≈3 ml of an emollient, previously shown to improve epidermal [i.e. skin] function

Changes in epidermal function and levels of three key, age‐related, plasma cytokines (IL‐1β, IL‐6 and TNFα) were measured at baseline and after treatment.

Circulating levels of proinflammatory cytokines in the body, IL‐1β, IL‐6 and TNFα, were higher in the older adults before the use of the emollient. After topical use, i.e, using the cream on their skin twice a day for 30 days:

circulating levels of IL‐1β and IL‐6 normalized, while TNFα levels declined substantially.

The authors suggest larger clinical trials to confirm this connection between high levels of proinflammatory cytokines and chronic inflammatory disorders and to show how improving skin health by moisturizing may prevent chronic inflammatory disorders such as heart disease, type II diabetes, osteoporosis and Alzheimer’s disease in older adults.

The University of California explains the mechanism:

Our skin starts to deteriorate around age 50 with changes to epidermal pH, hydration, and the permeability barrier, which keeps water in and bacteria and other potential pathogens out. A loss of moisture and breaks in the permeability barrier cause the skin to release inflammatory cytokines. Ordinarily, these cytokines help to repair defects in the barrier, but in aging skin the barrier can’t be fixed as easily, so the inflammatory signals continue to be released, eventually reaching the blood.

This article and the study authors are suggesting this is an issue to be addressed with older adults and with respect to the above chronic diseases, but there is enough research on the role of inflammation on anxiety and other mental health conditions at any age, that this study had me perk up and take notice. Also, if you’re young and not moisturizing or living in a dry climate or have other factors contributing to inflammation (more on that below), could this be happening too? I believe it’s highly likely.

The role of inflammation on anxiety and other mental health conditions

Here is one of the many anxiety-inflammation studies: Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond, reporting that:

heightened concentrations of inflammatory signals, including cytokines and C-reactive protein, have been described in posttraumatic stress disorder (PTSD), generalized anxiety disorder (GAD), panic disorder (PD), and phobias (agoraphobia, social phobia), etc.

And concludes that:

targeting inflammation may serve as a potential therapeutic target for treating these fear- and anxiety-based disorders in the future

Inflammation plays a role in depression too. This paper, Role of Inflammation in Depression and Treatment Implications reports that:

Numerous studies (including meta-analyses) have found elevated peripheral and central inflammatory cytokines and acute phase proteins in depression.

The ongoing inflammation affects neurotransmitters and makes antidepressants less effective:

Chronic exposure to increased inflammation is thought to drive changes in neurotransmitters and neurocircuits that lead to depressive symptoms and that may also interfere with or circumvent the efficacy of antidepressants.

Many approaches for reducing cytokines and inflammation

I do want to address the one statement in the emollient study where they say that “approaches that reduce circulating cytokines are not yet available.” There are, in fact, many approaches for reducing cytokines and inflammation.

In one study vitamin D supplementation improved mood, reduced anxiety and lowered markers of inflammation (CRP and IL-10) in female diabetics who had low levels of vitamin D.

In another study looking at anxiety in women with PCOS (polycystic ovary syndrome), probiotics and selenium improved their mental health and hormonal profiles, lowered markers of inflammation and reduced oxidative stress.

This paper lists a number of underling root causes that cause systemic inflammation and depression: psychosocial or life stressors, poor diet, physical inactivity, obesity, smoking, altered gut permeability (i.e. leaky gut), atopy (a genetic tendency to allergies – this could include gluten sensitivity), poor dental health, sleep issues and vitamin D deficiency.

Of course, these factors may also play a role in anxiety and using a functional medicine and nutritional approach, you can reduce the inflammation and eliminate the anxiety/depression. It’s a matter of finding your root cause/s and addressing them.

Research is also finding that GABA, one of the main calming neurotransmitters, may also have a possible role in “neuroimmune interaction, being involved in the modulation of immune cell activity associated with different systemic and enteric inflammatory conditions.”

Low zinc and low vitamin B6 are also factors in inflammation, and addressing low levels reduces inflammation and eases anxiety such as pyroluria (a social anxiety condition) and low GABA and low serotonin anxiety because zinc and vitamin B6 are co-factors for making these brain chemicals.

The benefit of touch and a boost of oxytocin

I’d like to mention other benefits of using a daily moisturizer – the benefits of touch, massage and a boost of oxytocin:

  • Hand massage and therapeutic touch has been shown to decrease anxiety and make the elderly in a nursing home feel more comforted. If you’re a caregiver to a parent, make daily moisturizing part of your routine.
  • Swedish massage reduces anxiety in ICU patients and improves vital signs.
  • Touch increases the release of oxytocin improving well-being and may also have “applications in neuropsychiatric disorders especially those characterized by persistent fear, repetitive behavior, reduced trust and avoidance of social interactions.”

Adding skin moisturizing to your daily self-care routine

I feel very comfortable saying you now we have a new tool – daily skin moisturizing – to add to your toolbox to help lower your markers of inflammation and reduce anxiety, panic, PTSD, phobias and social anxiety. Let’s use everything at your disposal to heal and feel your absolute best.

It’s something most women (and a few men) are already doing, and this information can give you more reason to continue to do it.

It’s a lovely self-care routine if you’ve not been doing it for some time or have never regularly used a moisturizer. This information can be an incentive to add it back to your daily routine or start doing it.

The biggest problem I see with moisturizing is using toxic chemicals and less than ideal creams on your skin so I reached out to colleagues and my community on Facebook to get input on their favorite home-made and store-bought moisturizers:

In the meanwhile, feel free to share your favorites and what your moisturizing self-care routine is like, and if you get regular massages and use moisturizing creams with love ones. Simply comment below.

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