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Mercury & gadolinium toxicity, iron overload, COVID-19: NBMI research update and potential applications

July 10, 2020 By Trudy Scott 9 Comments

mercury toxicity

Professor Boyd Haley set out to find a safe and non-toxic heavy metal chelator that would cross the blood-brain barrier, get inside the cells and bind mercury. The compound was initially sold as an antioxidant called OSR and is now called NBMI. In 2018 I wrote a blog about this – Mercury detox: NBMI as a safe and non-toxic heavy metal chelator. At the time NBMI was in phase 2 clinical trials. The blog was a popular one then and still gets many comments and requests for updates. Today I’m sharing some updates on progress, new studies and proposed new applications. I still find NBMI intriguing and look forward to it being readily available once the studies are completed.

The recent newsletter from EmeraMed, reports that their projects are all running according to plan (despite coronavirus setbacks) and “producing the anticipated positive results necessary to bring our drug to market. When we complete the studies requested last year by the FDA, EmeraMed will file a new drug application (NDA), which then starts the FDA approval process.” 

Studies on metal binding have shown that NBMI is strongly attracted to mercury, arsenic, lead, cadmium, uranium, gadolinium [used as a contrast agent in MRIs] and free iron and copper.

EmeraMed are expanding the clinical trials to look at other disorders that NBMI can potentially improve. These updates were shared in the newsletter:

  • The Colombian drug regulatory agency INVIMA approved a trial for mercury intoxication in May 2020:

…mercury intoxication and kidney disease are a serious life-threatening intractable condition and prominent in Colombia

…mercury from fish in the Santa Margareta river is one potential source for kidney injury leading to dialysis treatment. It will be a double-blind placebo controlled pivotal study, the participants health and results will be carefully monitored.

The treatment will be much longer than our earlier trials with gold miners and will look at numerous physiological parameters.

  • There are two pilot studies on iron overload in Europe:

Excess iron causes many devastating disorders, some lethal. Atypical Parkinson, an always fatal disease, is partially finished.

We expect to receive an interim report by July 2020 on a Thalassemia study that shows a highly significant benefit from NBMI. 8 out of 8 improved without any reported drug induce toxic side effects. “Impressive” in the words of one reviewer.

  • A potential use for COVID-19 based on NBMI increasing glutathione levels:

The mechanism of action is based on the ability of Emeramide to: 1; enter cells and cross the blood brain barrier, 2; scavenge and remove existing hydroxyl free radicals lowering oxidative stress and 3; chelate into non-reactive and non-toxic complexes several toxic metals and most importantly Fe2+ a redox metal that has been proposed to be displaced from hemoglobin by the COVID-19 infection.

We know NBMI would help because viruses need to release free iron to be able to reproduce. That iron causes oxidative stress possibly leading to a cytokine storm.

Another potential application is environmental clean-up of rivers, lakes and streams:

Arsenic (As) in drinking water is a well-recognized problem but since it is very difficult to remove, EPA maximum drinking water standard allows drinking water to have arsenic levels that cause significant amounts of bladder and lung cancers.

And one more potential application is the improved “treatment of waste-water sewer sludge to remove mercury or other toxic metals before it is spread on farms.”

Here is the mercury feasibility trial mentioned in the newsletter: Efficacy of N,N’bis-(2-mercaptoethyl) Isophthalamide on Mercury Intoxication: A Randomized Controlled Trial, where NBMI was given to 36 gold miners with high levels of mercury in their urine:

Although this study was designed with a small sample size to test for feasibility, the gained results with 300 mg NBMI already showed an effect on physical fatigue with statistical significance and there were indications to positive effects on other symptoms, like sleeping problems.

You can read more about this mercury research here.

The newsletter link above has information about which countries are allowing early access. Please contact the company directly rather than ask me about how to obtain the product as I am simply sharing what they have shared with me. I also encourage you to sign up for EmeraMed’s newsletter so you can keep up to date with progress and access information.

I find it intriguing and look forward to it being readily available once the studies are completed.

Please share if you used the original OSR product with any success or if you have managed to obtain NBMI and trial it?

And feel free to post your questions for Professor Boyd Haley. I’m hoping to have him speak on Anxiety Summit 6: Toxins/Meds/Infections.

Filed Under: Anxiety, Coronavirus/COVID-19 Tagged With: Boyd Haley, Coronavirus, COVID-19, emeramed, environmental, gadolinium toxicity, glutathione, iron overload, mercury toxicity, NBMI, toxicity, water treatment

Food Fix by Dr. Mark Hyman – my review

February 27, 2020 By Trudy Scott 4 Comments

food fix by mark hyman

Dr. Mark Hyman has a brilliant new book called called Food Fix: How to Save Our Health, Our Economy, Our Communities, and Our Planet – One Bite at a Time and his big bold message is that: “We need to change the food system to change the world.”  It is an issue that is seriously overlooked and he wants to change this.

food fix

Watch this short video clip to hear it from Dr. Hyman himself.

food fix

Here are some of the key messages from Food Fix

  • If we don’t change the food system, we’re going to spend $95 trillion dollars on chronic disease – heart disease, obesity, type 2 diabetes, cancer, and dementia – over the next 35 years.
  • Big food spends a lot of money in Washington to keep us fat and sick.
  • The food industry preys on our most vulnerable citizens – children.

According to the American Psychological Association, children under the age of 8 don’t instinctively recognize the difference between TV Commercials and programs, which makes them particularly vulnerable.

  • Big Food buys partnerships with public schools.
  • Minorities are also targeted by the food industry.

Researchers at the University of Connecticut found that junk food companies spend the most on ads that target African Americans and Spanish speakers. Guess which products were most heavily advertised toward minorities—Gatorade, Pop Tarts, Twix Candy Bar, Cinnamon Toast Crunch Cereal, and Tyson Frozen Entrees

The worse the nutritional profile the more heavily the products were promoted through advertising.

Where are the broccoli ads?

These findings, the researchers noted, “highlight important disparities in the food and beverage industry’s heavy marketing of unhealthy foods to Hispanic and black youth, and the corresponding lack of promotion of healthier options.”

  • Bad food is making us anxious, depressed, and is messing with our brains. I’m thrilled that Dr. Hyman highlights how nutritional medicine is a key to mental health and psychiatry. Here are some snippets :

Studies show that adults with many types of mental health issues and children with ADHD have very low levels of antioxidants (which come from fruits and vegetables), such as the fifty-six-year-old man with lifelong crippling depression who improved by cleaning up his diet and taking a cocktail of B vitamins. I remember one man who presented with severe panic attacks every afternoon. Turned out he was eating a diet very high in sugar and starch and had wild swings in his blood sugar, which triggered the anxiety. When he cut out sugar and starch, his anxiety and panic attacks vanished. These stories are not anomalies. They are predictable results from applying nutritional medicine.

In recent years, major medical journals have clearly shown the link between nutrition and mental health. The Lancet Psychiatry, a top medical journal, maps out just how nutritional medicine is a key to mental health and psychiatry. Overall diet quality, high sugar loads, and rampant nutritional deficiencies (including omega‑3 fats, zinc, magnesium, vitamin D, and B vitamins) all drive mental illness. In other words, the culprit is once again the American and increasingly global industrial diet. We have discussed the costs of obesity and chronic disease, but most don’t connect mental illness to the costs of chronic disease. In fact, the cost of mental illness to the economic burden is far greater than the costs of heart disease, diabetes, and cancer.

Population studies have found that more fruits and vegetables and less french fries, fast food, and sugar are associated with a lower prevalence of mental illness, and that junk food creates moderate to severe psychological distress. The good news is that interventional studies have shown that treatment of mental illness with diet works well (especially since most medications for mental illness don’t work that well, despite being the second biggest category of drugs sold).

And here are a few of the many solutions proposed in the book:

  • Support regenerative agriculture and sustainable food.
  • Stop purchasing franken-foods:

Today 60% of our diet is ultra-processed food made from commodity crops—corn, soy, and wheat—that’s turned into various sizes, shapes, and colors from the raw materials—high fructose corn syrup, white flour, and refined soybean oil. When you vote with your dollars and your fork to stay away from these foods, you send a message to big food to stop subsidizing commodity crops and grow more fruits and vegetables!

  • End food waste:

Buy only what you need.  If food may go bad soon, make a soup or stew. Get a compost bucket for your kitchen.  Start a compost pile in your backyard, or buy an in-home composter.  Use it in your garden or donate it to someone who has a garden.

  • Be an activist and teach your family why food matters.
  • Address food deserts and food swamps in African American communities, and recognize that this is:

“food apartheid,” an embedded social and political form of discrimination.

Here is the official book blurb:

Help to transform the planet in crisis with this indispensable guide to healthy, ethical, and economically sustainable food from #1 New York Times bestselling author Mark Hyman, MD.

Food is our most powerful tool to reverse the global epidemic of chronic disease, heal the environment, reform politics, and revive economies. What we eat has tremendous implications not just for our waistlines, but also for the planet, society, and the global economy. What we do to our bodies, we do to the planet; and what we do to the planet, we do to our bodies. 

In Food Fix, Mark Hyman explains how our food and agriculture policies are corrupted by money and lobbies that drive our biggest global crises: the spread of obesity and food-related chronic disease, climate change, poverty, violence, educational achievement gaps, and more.

Pairing the latest developments in nutritional and environmental science with an unflinching look at the dark realities of the global food system and the policies that make it possible, Food Fix is a hard-hitting manifesto that will change the way you think about – and eat – food forever, and will provide solutions for citizens, businesses, and policy makers to create a healthier world, society, and planet.

I love that Dr. Hyman says he is left with a sense of hope and possibility after writing this book … “understanding the problems and challenges we face sets the foundations for the solutions.”

Wise words indeed! This book is much-needed, brilliant, eye-opening and shocking at times, but hopeful and solution-based.

You can get your copy of Food Fix here (my Amazon link) and find additional information and resources on the official book site here.

Filed Under: Books Tagged With: African Americans, chronic disease, climate change, education, environmental, food, food and agriculture policies, food deserts, Food Fix, food swamps, mark hyman, mental health, nutrition, Nutritional medicine, obesity, poverty, psychiatry, the planet, violence

Mitochondrial Dysfunction in Anxiety with Tara Hunkin on The Anxiety Summit 5

October 18, 2019 By Trudy Scott 2 Comments

mitochondrial dysfunction

Tara Hunkin, NTP, CGP, RWP is one my guest experts on The Anxiety Summit 5: Gut-Brain Axis and our topic is: Mitochondrial Dysfunction in Anxiety. In this interview you’ll learn:

  • The role of mitochondria in the gut, brain and anxiety
  • Causes (such as medications and environmental toxins), testing, and signs and symptoms of mitochondrial dysfunction
  • Healing nutrients: Carnitine, COQ10, folinic acid, meal timing (as well as antioxidants and many other nutrients such as PQQ)

Tara starts with an overview of mitochondria, the energy powerhouses of our bodies and why they are so important in both physical and mental health.

You can hear some of this background information in this short in-person interview we did in San Diego recently.

You’ll also hear Tara share about this new bidirectional relationship that has been identified between anxiety and mitochondrial dysfunction.  One of the papers she is referring to this very recent 2019 review paper: Anxiety and Brain Mitochondria: A Bidirectional Crosstalk. Here are the highlights:

  • Despite the established link between mitochondrial dysfunction and various psychiatric disorders, the contribution of mitochondria in anxiety disorders has not been extensively addressed.
  • Mitochondria are emerging as modulators of anxiety-related behavior, as evidenced both in animal and human studies.
  • There is a bidirectional link between mitochondria and anxiety. Mitochondrial, energy metabolism, and oxidative stress alterations are observed in high anxiety; conversely, changes in mitochondrial function can lead to heightened anxiety.

Tara shares how important the mitochondria are when it comes to digestion and gut health too:

  • the liver is heavily mitochondrial-dense and is needed to help eliminate toxins we are exposed to (toxins that affect our mitochondria and increase anxiety)
  • the mitochondria are also important when it comes to digestion – the lining of digestive tract (the epithelial cells of the microvilli) contain large numbers of mitochondria

The authors also highlight that “Pharmacological manipulation of mitochondria may be a potential therapeutic approach to relieve high anxiety symptoms.”  One of the objectives of this summit is to highlight non-pharmacological approaches and Tara does exactly this in our interview.

She covers both lifestyle and nutritional approaches for addressing mitochondrial dysfunction (acetyl-l-carnitine, glutathione, antioxidants, coenzyme Q10, folinic acid and many more).

I also mention two other interviews on the summit where we talk about nutrients that also support mitochondrial function: PQQ (pyrroloquinoline quinone) and TUDCA (tauroursodeoxycholic acid).

Be sure to listen to these interviews for more about these two nutrients:

  • Jay Davidson, DC, PScD: Parasites, Anxiety and TUDCA for Your Liver
  • Michael Murray, ND: PQQ for Stress, Sleep, Mitochondria and Gut Health

tara hunkin and trudy scott

We also discuss testing and all the environmental factors that impact the mitochondria including medications such as risperidone/risperdal (and antipsychotic medication), valproic acid (used for seizures), fluoroquinolone antibiotics like Cipro (and others) and also benzodiazepines (the commonly prescribed anti-anxiety medications).

anxiety summit

Please join us and listen to this interview and all the others on The Anxiety Summit 5: Gut-Brain Axis.

When you register now you’ll get access to there 3 interviews right away:

  • Fix the Brain to Fix the Gut – Datis Kharrazian, DHSc, DC, MS, FACN, CNS
  • MTHFR, B12 Genes and Anxiety – Carolyn Ledowsky, ND
  • Why Bile is the Key to Anxiety & Hormone Havoc – Ann Louise Gittleman, PhD, CNS

anxiety summit 5 speakers

If you have already signed up for the summit, I hope you enjoy these interview highlights.

If you have yet to sign up, please do come and join us and learn.

Register for the Anxiety Summit 5

 

If you’re considering purchasing the summit to keep for your learning library, you have a number of options that include:

  • Online only or flash drive or both
  • A PDF or printed transcripts of all the interviews
  • The Best of Anxiety-Gut interviews from previous Anxiety Summits
  • GABA Quickstart Program (a group program with me on how to actually use GABA for your physical anxiety, with a private Facebook group and live Q & A call)
Purchase options

 

If you’d like to give feedback or ask a question, please post in the comments section at the bottom.

I’d love to hear from you once you’ve listened in to this interview and the others.

Filed Under: Anxiety Summit 5 Tagged With: anxiety, anxiety summit, benzodiazepines, bidirectional, digestive system, environmental, environmental toxins, fluoroquinolone, liver, mitochondria, mitochondrial dysfunction, PQQ, risperidone, Tara Hunkin, TUDCA, valproic acid

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