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Chronic Lyme Disease Summit – anxiety, pyroluria & more

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The Chronic Lyme Disease Summit runs from April 4th to 11th so I’m sharing some additional information for you.

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The response to this summit, hosted by Dr. Jay Davidson, is out of this world already. Lyme disease is much more talked about than most realize and more people are affected by Lyme disease each year than breast cancer!

Many people with chronic Lyme disease have chronic anxiety too and the focus of my interview is how to use targeted individual amino acids GABA and tryptophan to top up low levels of GABA and serotonin while the Lyme is being addressed.

This gives Lyme sufferers resolution from much of the anxiety (if not all) right away and they don’t need to resort to meds like benzodiazepines or anti-depressants (like the women in the study below). There is also a big connection between Lyme disease and pyroluria and I cover this too.

Here is one study that shows that Lyme-anxiety is very real and that panic attacks may actually be trigged by the Lyme disease:

A paper published in the Journal of Psychiatric Practice in 2000: Panic attacks may reveal previously unsuspected chronic disseminated lyme disease

describes the histories of three patients with panic-like episodes that turned out to be related to underlying, previously unsuspected tick-borne diseases.

Each woman experienced symptoms that are not usual in panic disorder but are typical of neurological Lyme disease, including exquisite sensitivity to light, touch, and sounds, joint pain often in combination with cognitive changes including mental fogginess and loss of recent memory, and some degree of bizarre, shifting, and often excruciating neurological pain. Because these symptoms are atypical of primary panic disorder, they were very helpful in alerting the clinician to suspect an underlying physical illness.

In each case, the results of testing revealed positive hallmarks of disseminated Lyme and other tick-borne diseases [ including Lyme borreliosis caused by the spirochete, Borrelia burgdorferi, babesiosis, and ehrlichiosis.] Since beginning treatment with intensive doses of appropriate antimicrobial medications for their tick-borne infections, all three patients have become free of panic attacks.

Treatment of their infections by a specialist in Lyme disease allowed one of the women to discontinue anti-anxiety medication completely and another to reduce the dose of medication to occasional use only. The third patient is no longer anxious but her depression is resolving more slowly despite the ongoing use of an antidepressant. Two of the patients have also needed ongoing medication for pain and other symptoms of late-stage, neurological Lyme disease

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One of my favorite presentations at the 2015 IMMH/Integrative Medicine for Mental Health conference was Dr. Suruchi Chandra’s Neuropsychiatric Lyme Disease talk. She shared that:

Lyme disease is one of the fastest growing infectious diseases in the United States. It can remain dormant for years and then later mimic a number of psychiatric illnesses, including anxiety disorders, mood disturbances, psychosis, and autism-like behaviors. It can be further complicated by the presence of co-infections.

Tune in to the summit to hear more about Lyme and anxiety and the amino acids GABA and tryptophan (and the Lyme-pyroluria connection).

(Please note: I’m not a Lyme disease expert – people seek me out for help with their anxiety and many of them also happen to have Lyme disease. The information we covered in the interview is very powerful for anxiety whether or not Lyme disease is a factor.)

Here are a selection of the many excellent Lyme interviews you’ll hear:

  • Dr. Jay Davidson, DC, PScD: Heavy Metal Detox and Lyme Disease
  • Connie Strasheim: Lyme Disease and Cancer
  • Jack Tips, PhD, CCN: The Gut Microbiome and Lyme disease
  • Shayne Morris, PhD: Biofilm, Bugs and Bacteriophage
  • Bradley Bush, ND: A Lab Test that Actually Works for Detecting Lyme Disease

When you register you get access to 3 talks right away – mine is one of the 3 talks! You can register here:
https://qt247.isrefer.com/go/LYME16reg/trudyscottcn

GABA helps with Lyme anxiety (while addressing the underlying disease)

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GABA is a calming amino acid that helps to reduce anxiety and panic attacks in individuals with low GABA levels and helps to address the anxiety that many individuals experience when they have Lyme disease.  

At the recent IMMH/Integrative Medicine for Mental Health conference Dr. Suruchi Chandra presented on Neuropsychiatric Lyme Disease and shared that:

Lyme disease is one of the fastest growing infectious diseases in the United States. It can remain dormant for years and then later mimic a number of psychiatric illnesses, including anxiety disorders, mood disturbances, psychosis, and autism-like behaviors. It can be further complicated by the presence of co-infections.

Last month I shared a post called GABA, the calming amino acid: expert opinions and Tricia Soderstrom, creator of the blog Abounding in Hope with Lyme shared it with her online Lyme community with this comment:

Lyme anxiety is real! We’ve used GABA with great success.

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Tricia shared further when I asked what had helped:

We’ve used Source Naturals GABA Calm sublinguals with good results. I learned about GABA helping anxiety and because I was treating my young daughter I purchased this because it was easy for her to take.

Lyme, Bartonella and Babesia are all known to cause anxiety and other psychological disorders ranging from mild to very severe. My daughter had it very severely but thankfully is much better now that we’ve treated the tick-borne diseases.

She also shared this excellent article by Pamela Weintraub as a resource: High Anxiety (Neurological Lyme Disease, Part Three)

I asked Tricia if I could share some of her daughter’s Lyme story and how GABA (and other nutrients) had helped with her anxiety while they were treating the Lyme disease. She kindly agreed and here are some excerpts from her blog post: How A Tick Bite Changed My Daughter – Part 2 Using Supplements To Nourish The Brain

When my third daughter turned 7 we had no idea that our whole lives were beginning to turn upside down by severe anxiety and OCD.

As that year progressed I noticed my …daughter incessantly washing her hands, pooling saliva in her mouth, clenching her fists until the skin around her knuckles turned bright white and repeating motions.  Her eyes were wider than normal and she became very fearful of things that never bothered her before.

At the same time, she was complaining of deep hip pain, pain in her feet, very bad headaches, motion sickness, nausea, heart palpitations and other symptoms….

Her anxiety grew, her obsessions controlled her and she was incapable of thinking rationally during these episodes.  With age her episodes became more frequent and more severe.

Tricia diligently searched for solutions for the Lyme disease that was impacting her daughter and herself. As Tricia learned more, she discovered the psychiatric connection to Lyme and they worked without success, with various doctors, having her daughter try antibiotic treatments and anti-anxiety and antidepressant medications.

Still searching, she discovered Dr. Klinghart teaching about pyroluria and started adjusting her daughter’s diet and adding various nutrients: magnesium, fish oil, trace minerals, vitamin D, evening primrose oil, vitamin B6 and zinc (the latter three are key for pyroluria).

Tricia then came across some of the amazing interviews I did with various experts on season 1 of the Anxiety Summit and it further consolidated what she had already discovered. She shares this:

What I learned was astounding and it was very similar to what [Dr. Kinghart] taught but I began to also learn about GABA, 5-HTP, L-Theanine, and L-Tryptophan.

To my daughter’s routine I added Source Naturals GABA Calm sublingual, Nature’s Way 5-HTP, Nature’s Way L-Theanine/ Green Tea sublingal, and Source Natural’s Melatonin.

At first we used GABA or L-Theanine whenever she would have a panic attack or her OCD was too much to deal with.  After awhile I just had her take it first thing in the morning, mid-day and then again in the evenings when her symptoms would be at their worst.

The amino acids and brain nutrients were ONE part of the solution, together with dietary changes, cognitive behavioral therapy (CBT), and homeopathy. As Tricia says:

These supplements did not cure my daughter but they helped her get off the prescription drugs and they helped both of us during our most trying times

This is why I love using targeted individual amino acids such as GABA. They give you immediate relief from anxiety and panic attacks while you are dealing with bigger underlying issues such as Lyme disease. Adding other nutrients (like zinc, magnesium, vitamin B6 etc) address nutritional deficiencies that the Lyme disease may be causing.

Keep in mind that Tricia’s daughter did well with Source Natural GABA Calm but there are many other excellent GABA products that can be beneficial too.

Tricia’s daughter has given her the go ahead to share her story and she is now doing so well!

My daughter is now a beautiful 15 year old, looking forward to her 16th birthday and getting her driver’s license.

She is the brave one to allow me to expose how this illness completely changed her and controlled her.  At one point she was embarrassed about it but now she really wants to help others.

What an encouraging, heartwarming and inspiring story!

Both Tricia and her daughter are very brave and I appreciate having the opportunity to share their story with you. I encourage you to read the whole story here on her blog.

Tricia also experienced Lyme-induced anxiety and she too found benefits with GABA. You can read more about her episodes of fear, panic attacks, fear of going outside and withdrawing from social situations on this blog post: Where Does Your Fear Come From And What Are You Doing About It? (Our Journey With Neurological Lyme)

Here is a little more about Tricia: She is a mom of 4 and wife of 26 years to Scott.  She was living a busy and active life as an outdoorsy homeschool mom, when chronic Lyme disease side-lined her and her entire family.  She has spent the past 8 years recovering, advocating and caring for her family and researching tick-borne diseases.  Tricia continues to homeschool her youngest two children and blogs about her life as a Christian homeschool mom with chronic Lyme, while homeschooling her children who also have chronic Lyme.  She is passionate about educating others about tick-borne disease, and how to prevent, recognize and get the proper treatment. You can read more about her and her Lyme resources here. And you can find Tricia on Facebook here AboundinginHopewithLyme

I’d love to hear if you have used GABA (or one of the other amino acids) to help with your anxiety while undergoing treatment for Lyme disease.

Dr. Klinghart discusses the connection between Lyme disease and pyroluria. I’d also love to hear if you have Lyme disease and also have pyroluria? You can do the pyroluria questionnaire here.

Zinc/copper balance in autism/pyroluria: Dr. Usman

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This is such a great segment on zinc/copper balance in pyroluria and autism so I really want to share it in advance of Dr. Usman’s interview tomorrow Friday January 15th. Dr. Usman one of many excellent speakers on the Autism Intensive.

An excerpt from Dr. Usman’s interview: Optimizing Metabolic-Immune Communication and Function, on the Autism intensive

Dr. Usman: …. In the 70s, they were breaking down individuals with schizophrenia into three phenotypes: low histamine, high histamine and pyrolurics. At the time this phenotype of pyroluria in schizophrenia was manifest as a B6, zinc deficiency and when they were given high doses of B6 or zinc, their schizophrenia improved.

Dr. Schwartz: So that was kind of your first exposure to nutritional vitamins.

Dr. Usman: Yeah. I was treating patients with depression, bipolar disorder, schizophrenia, mental illness with these various protocols that Carl Pfeiffer had developed. I started doing research in copper/zinc imbalances. We had over 500 patients with autism involved in a study that we look at there. We look at plasma zinc and serum copper ratios. When you ratio plasma zinc to serum copper what you’re looking for is a ratio of 1 to 1.

Dr. Schwartz: Balance is more important than the absolute number.

Dr. Usman: Correct.

Dr. Schwartz: Another concept that takes us outside the traditional lab values?

Dr. Usman: Exactly. You’re not looking at a lab number, but you’re looking at a ratio.

Dr. Schwartz: So both zinc and copper could be in the normal range, but the ratio can be way off. That’s something I’ve certainly seen in my patients.

Dr. Usman: Correct. When the ratio of copper and zinc is off, we want that ratio to be one-to-one. And patients with inflammatory issues and patients with various autoimmune issues and sick patients in general, their ratio ends up being disturbed. We found out in the autistic population was that 99% of them, which is a very low P value in statistics.

Dr. Schwartz: Zero, zero, zero, zero.

Dr. Usman: Zero, zero, zero, zero. 99% of them had low zinc, high copper and they had a high ratio of copper to zinc – of over 1.2.

Dr. Schwartz: So very dramatic.

Dr. Usman: Yeah. Then Dr. Walsh, who headed the Pfeiffer treatment center, had a theory that this was due to defect in a protein called metallothionein. Metallothionein is a protein that, in a way, transports copper and zinc through the body.

If you enjoyed this and would like to hear Dr. Usman’s complete interview, it airs as part of the Autism Intensive on Friday January 15th. Her talk is titled: Optimizing Metabolic-Immune Communication and Function.

You can register to get access to this and all the speakers here https://mutzelnutrition.isrefer.com/go/1129/trudyscottcn

MTHFR, Depression and Anxiety with Carolyn Ledowsky

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The Healthy ME Summit: Overcoming Depression and Anxiety runs Jan 7-17, 2016. Here are some snippets from the excellent interview with Carolyn Ledowsky, Naturopath, Herbalist, Nutritionist: MTHFR, Depression & Anxiety.

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MTHFR is a gene that helps the conversion of folate to the active form. When you eat leafy greens the body goes through many metabolic processes to change the folate to an active folate and this active folate is what we call a methyl group.

It’s this methyl group that acts as a master switch in really important processes in our body… it helps detoxify chemicals and heavy metals, and really importantly it helps us make glutathione (our major antioxidant that protects us from free radical damage), it helps to process hormones and it’s really important in the stress response.

Stress uses up a lot of our methyl groups and some people use up all their methyl groups when they are really stressed. They can turn the stress response on but then they don’t have enough to turn it off so they stay in this hyper-stress state.

If you have a lack of methyfolate or methyl groups then you don’t have enough components to generate neurotransmitters like serotonin and dopamine.

I would say 80% of people with MTHFR who come to our clinic would experience anxiety or depression and for some of them it’s had a huge impact on their lives and they just can’t function.

Carolyn shares some of the early research on folate and depression, psychosis and schizophrenia; how SAMe is the distributor of all these really important methyl groups to every part of the body; the importance of vitamin B12, zinc, vitamin B6 and how elevated homocysteine is neurotoxic and has a massive impact on mood; how the mutations in the COMT gene can make you less able to tolerate methylfolate; why a vegan or vegetarian diet can be a big factor with anxiety and depression.

She also covers pyroluria (and low zinc and low vitamin B6) as well as high copper and infections:

You can actually get a copper toxicity depression (even without pyroluria). You can have high copper with estrogen dominance, low iron, low molybdenum and one of the key strategies is to balance copper and zinc (and look at why zinc is low to start with)

Strep infections can increase excitatory receptor activity, decreasing GABA levels and impairing speech in kids with autism

It’s a really excellent interview and not to be missed!

Here are more details about the Healthy ME Summit: Overcoming Depression and Anxiety, January 7-17, 2016.

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You will discover 50 of the brightest and most brilliant minds in the field of mental health and wellness. The interviews are a collection of experts, as well as individuals sharing their inspirational personal experiences. The culmination of both of these points of view provides you the listener with the answers and solutions to your mental health challenges.

Here are a few of the other excellent speakers and topics:

  • Nicole Bijlsma, Author, Naturopath, Acupuncturist: Mould The New Asbestos [this is the Australian spelling of mold]
  • Therese Kerr, Author, Speaker, Health Ambassador: Chemicals in Cosmetics to Avoid
  • Amy Myers, MD, Author: The Autoimmune Solution for Mental Health
  • Reed Davis, Functional Nutritionist: Addressing Metabolic Chaos

I’m thrilled to be included in this line-up of experts and I’ll be sharing Nutritional Solutions for Anxiety – and will cover the amino acids GABA and tryptophan, and the social anxiety condition pyroluria.

Hope you can join us! You can learn more and register here:
http://overcomingdepressionandanxiety.com/infuisonsoft.php?p=TrudyScott&w=hme

Joint hypermobility / Ehlers-Danlos Syndrome and pyroluria?

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Brighton Diagnostic criteria for the Joint Hypermobility Syndrome (source: http://ednf.org/assessing-joint-hypermobility)

I recently received a question about the possible connection between joint hypermobility / Ehlers-Danlos Syndrome and pyroluria. It’s been on my long list of topics to look into, learn more about and write about because I also feel there may be a connection to pyroluria, a social anxiety condition. People with pyroluria can often relate to these symptoms: joints popping, cracking, or aching; pain or discomfort between the shoulder blades; or cartilage problems (likely due to low zinc levels).

So here goes, I’ll share what I know so far. I’d love to gather more information and am looking for feedback too so please do share your experiences in the comments.

Joint hypermobility syndrome is described in this British Medical Journal paper: by expert Professor Rodney Grahame:

Joint hypermobility syndrome (JHS), previously known as benign joint hypermobility syndrome (BJHS), is a heritable disorder of connective tissue that comprises symptomatic hypermobility predisposing to arthralgia, soft tissue injury, and joint instability. It is indistinguishable from the hypermobility type of Ehlers-Danlos syndrome.

Complications may include autonomic dysfunction, proprioceptive impairment, premature osteoarthritis, intestinal dysmotility, and laxity in other tissues causing hernias or uterine or rectal prolapse.

Symptoms are often minimal or mild, but 168 out of 700 patients with joint hypermobility syndrome (24%) attending the UCH Hypermobility Clinic already had an established chronic pain syndrome at the time of their first outpatient attendance. These patients were experiencing serious pain, disability, and impairment of the quality of life, some patients becoming chairbound or even bedbound.

As reported in this Dec 2014 paper: United States Physical Therapists’ Knowledge About Joint Hypermobility Syndrome Compared with Fibromyalgia and Rheumatoid Arthritis despite the fact that joint hypermobility syndrome is one of the most common inherited connective tissue disorders, “many physical therapists in the United States are not familiar with the diagnostic criteria, prevalence or common clinical presentation.”

This is the actual request that I received from Catriona, one of my blog readers/facbeook followers:

I was wondering if you’d ever be interested on doing a post on Ehlers-Danlos Syndrome/Joint Hypermobility. I wonder whether many of your clients suffer from it and possibly don’t even realize. It’s a group of connective tissue disorders which had mostly been thought to affect only the joints, skin, skeleton and blood vessels, but it turns out that connective tissue is a necessary part of all organs and that there are much higher than expected incidences of anxiety, depression, chronic pain which is often labelled as fibromyalgia, gastrointestinal problems and more. I suspect a lot of people with EDS [Ehlers-Danlos Syndrome] also have pyroluria, there are high numbers of people having to deal with POTS [Postural orthostatic tachycardia syndrome] and MCAS[Mast Cell Activation Syndrome] and very high levels of disability with it. I think that having connective tissue in the gut that might be more prone to tearing and leaking might make dietary changes even more important, but might also be one of the things that results in less good responses to nutrient therapies. As well as that there are so many people with EDS on cocktails of medications for pain, sleep, anxiety, depression, reflux, IBS, menstrual disorders etc. and I can’t help but wonder whether all those medications are actually sometimes making things worse for some. Is it something you’ve come across much? Thanks.

There are a number of papers published in 2014 and 2015 linking EDS / Ehlers-Danlos Syndrome with psychiatric disorders. None mention social anxiety but anxiety is very common, as is depression.

Here is one paper that was published October 2015: Psychiatric disorders in Ehlers-Danlos syndrome are frequent, diverse and strongly associated with pain

Psychiatric disorders were found in 42.5 % of the EDS cohort, with 22.7 % of patients affected with 2 or more psychiatric diagnoses. Anxiety and depression were most commonly reported, with frequencies of 23.6 and 25.5 %, respectively.

This paper was published in April 2015, looking postal survey results from 250 members (over 18 years) of the Swedish National EDS Association: Self-reported quality of life, anxiety and depression in individuals with Ehlers-Danlos syndrome (EDS): a questionnaire study

Of the respondents 74.8% scored high on anxiety and 22.4% scored high on depression on the HADS [Hospital Anxiety and Depression Scale]

This March 2015 paper: Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers-Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised addresses generalized joint hypermobility and other disorders as well as anxiety:

Psychological distress is a known feature of generalized joint hypermobility (gJHM), as well as of its most common syndromic presentation, namely Ehlers-Danlos syndrome, hypermobility type (a.k.a. joint hypermobility syndrome – JHS/EDS-HT), and significantly contributes to the quality of life of affected individuals.

Interestingly, in addition to the confirmation of a tight link between anxiety and gJHM [generalized joint hypermobility], preliminary connections with depression, attention deficit (and hyperactivity) disorder, autism spectrum disorders, and obsessive-compulsive personality disorder were also found.

Of course the big question is which comes first ?

  • the EDS and pain leading to feelings of anxiety and depression
  • or the genetic factors that cause nutritional deficiencies affecting both connective tissue and contributing to anxiety/depression

I’d guess it’s likely a combination of both and that it’s going to vary by individual.

The website of the Ehlers-Danlos Syndromes National Foundation is an excellent resource for learning about the condition but interestingly they make no mention of psychiatric symptoms.

Here is some feedback I’ve received up until now, on my blog, about a possible connection to pyroluria:

  • As you can see in this blog post: Pyroluria prevalence and associated conditions Thin Basement Membrane Disease (an inherited collagen/connective tissue disorder diagnosed via kidney biopsy) may be related to pyroluria. Someone contacted me during season 3 of the Anxiety Summit and said she has pyroluria and TBMD/Thin Basement Membrane Disease. She shared that the pyroluria protocol helped with her TBMD/Thin Basement Membrane Disease symptoms.
  • Maruschka posted on the same pyroluria blog sharing this (slightly edited version): pyrrole disorder/pyroluria is big part of hypermobility, Ehlers Danlos syndrome 3 and mixed connective tissue disorder. 80% of us suffer with pyrrole in collagen issues. Often undiagnosed. Professor Rodney Grahame says every 5 people in 30 people we meet have it. Now there is a talk that hypermobility is induced by environment, so epigenetics could reverse it.
  • Ali commented on this blog post: Pyroluria, Amino Acids and Anxiety: Troubleshooting when you are not getting results saying she “immediately identified with almost all of the symptoms on your pyroluria questionairre, and ordered the test through Direct Health Care (the lab Dr. Walsh recommends). I ended up getting a mild positive urinary kryptopyrrole result .” She has also been “diagnosed with mast cell activation disorder (MCAD) and autoimmune disease (lupus, Hashimoto’s thyroiditis, celiac disease, Raynaud’s, interstitial cystitis), and Ehlers-Danlos Syndrome Type 3.” The pyroluria protocol does not seem to help her but she does have a great deal going on with her health.
  • Candy commented on the above post too, saying she has been diagnosed with Ehlers Danlos Syndrome and relates to many of the pyroluria symptoms.

I received this feedback from a colleague, Dr. Josh Friedman, an integrative psychotherapist who uses amino acids and other nutritional approaches in his practice. (You may remember him from the Anxiety Summit season 1 and then he interviewed me in season 3

One thing that I have noticed in the few folks in my practice with EDS (small sample of 4-5) is that that they tend toward low cholesterol (below 160 total) and do well with cholesterol supplementation. They do suffer from anxiety and/or depression. It seems pyroluria is a factor in some but not others (I have used the questionnaire from your book).

I look forward to learning more so I can help more people with social anxiety and hopefully some of the symptoms that may overlap with joint hypermobility and Ehlers-Danlos Syndrome.

Have you been diagnosed with joint hypermobility or Ehlers-Danlos Syndrome? And do you have pyroluria? If yes we’d love to hear if the pyroluria protocol of zinc, vitamin B6, evening primrose oil and a good copper-free multi has helped?

If you have been diagnosed with joint hypermobility or Ehlers-Danlos Syndrome and have social anxiety, we’d love to hear how you score on the Pyroluria Questionnaire

What approaches (nutritional and otherwise) have helped you? And please do share additional resources if you have them.

 

The Antianxiety Food Solution Amino Acid and Pyroluria Supplements

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antianxiety food solution and amino acids

Here are my amino acid and pyroluria supplement recommendations. These are the products I use with my one-one clients and those doing my online group programs.

Most links are from my online store Emerson Ecologics:

  • You can find details at the end on how to make your purchase
  • You will first need to set up an account

A few of them can be purchased in health stores or via other online stores.

 

Questionnaires and information

My publisher would not allow me to make specific product recommendations in my book so this list is a courtesy to those of you who have purchased the book.

If you do not have my book I highly recommend getting it and reading it before jumping in to taking supplements: The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings

There is a complete chapter on the amino acids and one for pyroluria, plus information on real whole food, sugar and blood sugar, gluten, digestion and much more.

Once you have read it you can use these blogs as summaries (they do contain some information that is not in my book).

Here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution and additional information on Anxiety and targeted individual amino acid supplements: a summary

Please read and follow these Amino Acid Precautions
 

Here is the Pyroluria Questionnaire from The Antianxiety Food Solution and additional information on Pyroluria, social anxiety, introversion: a summary

 

Supplements for Low Blood Sugar (anxious, shaky between meals and intense sugar cravings)

Glutamine helps with low blood sugar, may help eliminate the strong desire for something sweet when opened on to the tongue, and is very healing for the digestive system

  • Pure Encapsulations Glutamine 500mg: L-glutamine (free-form) 500 mg, vitamin C (as ascorbyl palmitate) 5 mg. The capsules can be swallowed or the capsule can be opened on to the tongue

 

Supplements for low GABA (stiff and tense muscles, anxious, panic attacks, use sugar/wine to relax)

GABA helps to raise GABA levels.  I find GABA to be most effective when taken sublingually or opened on to the tongue. I find GABA to be more effective than pharmaGABA for most of my clients. I don’t ever use phenibut.  Here are some GABA products that I like.

  • Source Naturals GABA Calm. This is a pleasant-tasting sublingual product that you can buy at your local health-store and some online stores. Emerson does not carry it (yet!). This is my most popular and most effective form of GABA I use with my clients.
  • ProThera 500mg GABA: GABA (Gamma-aminobutyric acid) 500 mg.  You will likely need to open this up and start with less than a full capsule during the day (a full capsule may be fine at night) 
  • Designs for health Stress Arrest: Niacin (niacinamide) 100 mg, Vitamin B6 (pyridoxine HCL) 10 mg, Pantothenic acid (d-calcium pantothenate) 100 mg, GABA 300 mg, Glycine 200 mg

 

Supplements for low serotonin (worry, rumination, negativity, afternoon and evening cravings and insomnia)

Tryptophan and/or 5-HTP can help to raise low serotonin. I typically recommend starting with tryptophan and don’t recommend 5-HTP if you have high cortisol as it can raise cortisol. Some people do better on tryptophan and some do better on 5-HTP.

  • Lidtke l-Tryptophan 500mg: L-Tryptophan 500 mg (120 count).  I only recommend the Lidtke brand for tryptophan as quality is a big consideration when it comes to tryptophan. This can be opened and/or chewed but doesn’t taste good. It can be mixed with inositol powder to make it more pleasant (see below) or with mashed banana. NOTE: This is not the same as the Lidtke Tryptophan Complete which has ingredients other than tryptophan making it more difficult to titrate up.
  • Lidtke l-Tryptophan Chewable: 2 tablets have L-Tryptophan 200mg. This chewable form is both good and bad. It’s good because it’s a nice 100mg of tryptophan per tablet, is chewable, tastes good and would be suitable for kids and pixie dust people. The bad aspect is that it does contain sugar and is quite sweet. Because you are continually consuming something sweet you may end up over-consuming them if sugar addiction is your issue.
  • Pure Encapsulations 5-HTP 50mg: 50mg 5-HTP. Some of my clients do better on 5-HTP and some find taking this during the day and tryptophan at night works well for them.
  • Designs for Health Inositol is fabulous for obsessive thoughts/behaviors that the tryptophan isn’t quite enough for. It’s also been shown to be very helpful for OCD itself. The powder has a slightly sweet taste and I recommend taking it in the powdered form. You can take up to 18g a day but I suggest starting with 2g a day and building up as needed. I think it  makes a great addition for mixing into the nasty tasting tryptophan – I suggest starting with 2g inositol per 500mg tryptophan.
  • Douglas Labs 1mg melatonin sublingual – If the tryptophan isn’t enough for sleep issues, adding this often helps if you can’t fall asleep (and if it’s a low serotonin/low melatonin issue). Start with one and increase to 3 as needed
  • Douglas Labs 3mg melatonin prolonged release If the tryptophan isn’t enough for sleep, adding this often helps if you wake in the night and if it’s a low serotonin/low melatonin issue. Start with one and increase to 2 as needed.

 

Supplement for low endorphins (comfort and reward eating, weepy, pain issues)

DPA or D-Phenylalanine is the amino acid that helps to raise endorphins and eliminates the comfort/reward eating

  • Lidtke Endorphigen 500mg: Riboflavin 5mg, Pyridoxal 5-phosphate 5mg (enzymatic form of vitamin B6), D-Phenylalanine 500mg. This is one of my top products that I recommend. This comes in a gelatin capsule and tastes quite pleasant when chewed – some people think it has a dark chocolate-like taste. A few people don’t like the taste at all

 

Supplement for low catecholamines (tired, coffee-drinking, blahs, poor focus, low motivation)

Tyrosine is the amino acid that helps to raise low catecholamines and can often help you quit coffee.

 

Vitamin C for negating the effects of any amino acid

Vitamin C 1000mg is used to negate the effects of any amino acid. I used to use EmergenC but this still contains folic acid, so here are some good alternate vitamin C recommendations:

  • Designs for Health C + Biofizz: Vitamin C 2569 mg (as Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate) Quercetin 20 mg Hesperidin 20 mg Rutin 10 mg. This one mixes nicely in water and can also be added to a smoothie but tastes quite sweet for many people. I personally prefer less of a sweet taste.
  • Designs for Health Buffered Vitamin C: Vitamin C (as ascorbic acid) 2000 mg, Calcium (as calcium ascorbate) 80 mg, Magnesium (as magnesium ascorbate) 160 mg, Potassium (as potassium bicarbonate) 200 mg. This one doesn’t mix very well in water and can also be added to a smoothie. The taste is not very pleasant.

 

The supplements for pyroluria

Zinc, vitamin B6, evening primrose oil and a good copper-free multivitamin are what I use for my clients with pyroluria or for those who score above 15 on the questionnaire:

  • Solaray OptiZinc 30mg. Zinc (as Zinc Monomethionine [OptiZinc®] 30 mg, Vitamin B6 (as Pyridoxine HCl) 20 mg. The zinc in this form seems to be well absorbed by many of my clients and is available over the counter. This also does not contain copper. Be careful as there are other OptiZinc products on the market that do contain copper (Source Naturals is one example)
  • Douglas Labs Opti-Zinc: Zinc (from 150 mg Zinc Monomethionine) 30 mg. The zinc in this form seems to be well absorbed by many of my clients. This also does not contain copper.
  • Designs for Health Zinc Challenge: Zinc sulphate monohydrate in a base of distilled water. Each 2 tsp provides Zinc sulfate monohydrate 8 mg. Use this for testing your zinc status as described here: Zinc deficiency is common: using liquid zinc status test as an assessment tool
  • Here are a selection of 100 mg Vitamin B6/pyridoxine. Use dream recall as a way to monitor if it’s working, plus social anxiety and mood improvements. If this doesn’t work you may need to use the activated form in conjunction with or instead of this one (see below)
  • Pure Encapsulations P5P 50 (activated B-6): pyridoxal 5 phosphate (activated B6) 50 mg, vitamin C (as ascorbyl palmitate) 3 mg. This activated form of B6 may be needed if the 100-500 mg B6/pyridoxine doesn’t work or may be needed in addition to vitamin B6/pyridoxine. Use dream recall as a way to monitor if it’s working, plus social anxiety and mood improvements.
  • Now Foods Super Primrose 1300mg: Evening Primrose Oil (Oenothera blennis) (Seed) 1.3 g (1300 mg) – 120 count. GLA is often low in pyroluria and EPO helps with zinc absorption and PMS symptoms.
  • Designs for Health Twice Daily Multi:This is a good copper-free multi. It also contains Folates (NatureFolate™ blend) 400 mcg instead of folic acid (no DFH products contain folic acid).

Free form amino acids and magnesium

Liquid and powder options for children

Here are some liquid and powder options for children (or for adults, if you have a hard time swallowing pills):

 

 

Emerson Ecologics – my online store

Most of the above links are from Emerson Ecologics, my online supplement distributor of quality professional grade supplements.

  • You will need to set up a customer account under my practitioner account. The access code is calm23 and my zip code 96511.
  • I have researched the products I recommend – quality is key when it comes to supplements just as it is key when it comes to food
  • They carry everything except a few products I recommend – Source Naturals GABA Calm and Solaray Optizinc (which you can purchase at your local health store) and Interplexus Seriphos (which you can purchase from Interplexus) – so it’s one-stop shopping.
  • They do ship most products internationally

The above statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.  Check with your doctor before starting a new supplement program.