Pyroluria Questionnaire from The Antianxiety Food Solution

October 13, 2011

lonely woman
This questionnaire will help you identify whether you might have pyroluria, a social anxiety condition. The physical and emotional symptoms below are caused by deficiencies of vitamin B6 and zinc. When you experience high levels of stress, vitamin B6 and zinc will be further depleted, so you may notice worsening symptoms and more anxiety.

Based on my review of questionnaires and results of pyroluria tests for hundreds of clients, I’ve grouped the most common or classic signs and symptoms first. I’ve also labeled the symptoms that could be directly related to low levels of vitamin B6 or zinc so you can individualize your supplements and dosages. Symptoms without these designations are due to a deficiency of both vitamin B6 and zinc. Check off any of the following signs or symptoms that apply to you:

Most Common Signs and Symptoms

1. Being anxious, shy, or fearful or experiencing inner tension since childhood, but hiding these feelings from others
2. Having bouts of depression or nervous exhaustion
3. Poor dream recall, stressful or bizarre dreams, or nightmares (low vitamin B6)
4. Excessive reactions to tranquilizers, barbiturates, alcohol, or other drugs, in which a little produces a powerful response (low vitamin B6)
5. Preferring not to eat breakfast, experiencing light nausea in the morning, or being prone to motion sickness (low vitamin B6)
6. White spots or flecks on the fingernails or opaquely white or paper-thin nails (low zinc)
7. Liquid zinc sulfate having a mild taste or tasting like water (low zinc)
8. Poor appetite or having a poor sense of smell or taste (low zinc)
9. Joints popping, cracking, or aching; pain or discomfort between the shoulder blades; or cartilage problems (low zinc)
10. Pale or fair skin or being the palest in the family, or sunburning easily, now or when younger
11. Disliking protein or having ever been a vegetarian or vegan
12. Being sensitive to bright sunlight or noise
13. Upper abdominal pain on your left side under the ribs or, as a child, having a stitch in your side as you ran
14. Frequent fatigue
15. Being prone to iron anemia or low ferritin levels
16. Tending to have cold hands or feet
17. Having frequent colds or infections, or unexplained chills or fever
18. Reaching puberty later than normal or having irregular menstruation or PMS
19. Having allergies, adrenal issues, or problems with sugar metabolism
20. Having gluten sensitivity
21. Neurotransmitter imbalances, especially low serotonin
22. For women, belonging to an all-girl family or having look-alike sisters
23. For men, having a mother from an all-girl family or a mother with look-alike sisters, or all the females in the mother’s family bearing a strong resemblance to each other
24. Avoiding stress because it upsets your emotional balance
25. Tending to become dependent on one person whom you build your life around
26. Preferring the company of one or two close friends rather than a gathering of friends; becoming more of a loner as you age
27. Feeling uncomfortable with strangers
28. Being bothered by being seated in the middle of the room in a restaurant
29. Being easily upset by criticism

Less Common Signs and Symptoms

30. Stretch marks or poor wound healing (low zinc)
31. Crowded upper front teeth, many cavities, or inflamed gums or wearing braces (low zinc)
32. Bad breath and body odor (or a sweet, fruity odor), especially when ill or stressed (low zinc)
33. Being prone to acne, eczema, herpes, or psoriasis
34. Reduced amount of hair on your head, eyebrows, or eyelashes, or prematurely gray hair
35. Difficultly recalling past events and people in your life
36. Focusing internally, on yourself, rather than on the external world
37. Tending to have morning constipation
38. Tingling sensations or muscle spasms in your legs or arms
39. Feeling stressed by changes in your routine, such as traveling or being in new situations
40. Your face looking swollen when you’re under a lot of stress
41. Cluster headaches or blinding headaches
42. One or more of the following: a psychiatric disorder, schizophrenia, high or low histamine, alcoholism, learning and behavioral disorders, autism, or Down syndrome

If you check off 15 or more items, especially the more common ones, it’s highly probable that you have pyroluria and will benefit from taking zinc and vitamin B6 supplements. I encourage you to be tested, but if this isn’t possible, or even if you don’t have pyroluria, supplementing with zinc and vitamin B6 may be worthwhile if you have a large number of these symptoms.

This questionnaire is based on my experience working with many clients with pyroluria, along with information from Depression-Free Naturally (2001), by Joan Mathews-Larson, Nutrition and Mental Illness (1987), by Carl Pfeiffer, and Natural Healing for Schizophrenia and Other Common Mental Disorders (2001), by Eva Edelman.

I start my clients with zinc (30 mg), vitamin B6 (100mg) or P5P (25mg) and evening primrose oil (1300mg), plus a good multi-vitamin (with manganese and no copper) and a multi-mineral and sometimes additional magnesium.

For the zinc I have found Opti-zinc (Solaray is a good brand that doesn’t have copper) to be very well absorbed by most of my clients. Using the liquid zinc sulfate/zinc status test is a useful way to assess your zinc levels (see link below).

We increase zinc based on the zinc test and the vitamin B6 based on dream recall. And obviously social anxiety symptoms too.

This questionnaire and information is taken from chapter 7 of The Antianxiety Food Solution: How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood and End Cravings, available in major books stores and via Amazon. You can read more about the book here.  You can find more detailed information in chapter 7.

11/5/2013 update – since doing this post, I’ve done a number of other posts related to zinc, vitamin B6, pyroluria and even introversion  and I am including links to some of them here: 

The comments on the posts about anxious introverts and the possible connection to pyroluria and/or low zinc and low vitamin B6 have been enlightening to say the least! Additional comments and feedback is always appreciated.
 
YOU’RE WELCOME TO INCLUDE THIS ARTICLE IN YOUR EZINE OR WEBSITE AS LONG AS YOU INCLUDE THIS COMPLETE BLURB WITH IT:

Trudy Scott (CN), Certified Nutritionist is the founder of www.everywomanover29.com, a thriving nutrition practice with a focus on food, mood and women’s health. Trudy educates women about the amazing healing powers of food and nutrients and helps them find natural solutions for anxiety and other mood problems. Trudy’s goal for all her clients (and all women): “You can be your healthiest, look your best and feel on-top-of-the-world emotionally!”

 

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657 Comments on "Pyroluria Questionnaire from The Antianxiety Food Solution"

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Lisa Manyon
Lisa Manyon

Wow, Trudy. That’s a lot of info to digest. I think I’ll just start taking my vitamins. 🙂

Write on!~

Lisa

Katie Beros
Katie Beros
Hi Trudy, I have been taking liquid zinc sulfate and feel so much better on it than the amino acid chelate tablet form. I sleep better and with the liquid zinc and 100mg of B6 and feel I can handle life better without the inner tension. A question I have is how do you deal with copper leaving the body if it is an issue for someone due to zinc copper problem particulary with A blood groups as they tend to accumulate copper easier than other blood groups I have read about this issue. Thankyou so much for doing this… Read more »
Katie Beros
Katie Beros

ps. I am taking Liquid zinc by nutrition care and I live in Western Australia.

Katie
Katie
May
May
Hi Katie, I’m in Western Australia too! Can you remember how much the liquid zinc cost you? There’s no price on the website and it says their online store is coming soon. I bought a Bioceuticals brand today from Health Kick at Joondalup for $20.95. 50ml and you take 5 drops once daily. Interested to compare price. They also have a P5P B6 but it comes with magnesium. When I’ve taken magnesium in the past I’ve found that my heart area feels fluttery so I hope that doesn’t happen this time 🙁 Where did you find your B6? Thank you… Read more »
Tracy
Tracy

Trudy, I love your work. Thank you for bringing this info to people’s attention. I just wanted to mention a product called Zinc Drink by Metagentics. It has 15mg of zinc sulfate per teaspoon and costs $28.95 for 28 servings.

Joanne
Joanne

Dear Trudy, i read the above response with interest because i believe i need zinc but when i try supplementing i get anxiety (worse than normal) it lasts about a day or so.
I have most of the symptoms on the list!
I am having an infrared sauna at home soon hoping this helps detox and the copper which seems to be my problem. Any suggestions for me to safely get extra zinc please?
Thanks you

Joanne
Joanne

Hi Trudy,
Thanks for your response. I think i was using Solgar zinc no idea what type sorry. I also had tried some zinc gluconate 15mg combined with selenium which also gave me anxiety (i take other selenuim fine) I have bought (unused!) Optimal zinc lozenges which are 15mg zinc bisglycinate chelate. What do you think about these?

I have used in the past diazepam, 2-5mg very sparingly and only when desperate. Havent used for couple of years at all because I hate the thought of them and have discovered adaptogens 🙂

Joanne

susz
susz
Hi Trudy, I am so excited to find your site. I am a mental health professional at a big health insurance medical facility in Northern California and I have been discouraged by the over providing of SSRIS and medication without really assessing them or finding alternative ways to help people. I am anxious to get more education so I can help my patients learn that their problems ( anxiety, depression, constant tears, irritability,insecurity, etc.) may and can go away naturally. Mine did without medication. I wholeheartedly praise what you are doing and am grateful for your work. I have been… Read more »
Elke Schmitt
Elke Schmitt
What amazing information.I have a lot of the above mentioned symptoms. Earlier this year I suffered an emotional explosion, a severe eczema outbreak. Due to a very stressful situation in the family. I call it emotional explosion, because I looked like I was in an explosion. My skin looked burned and blistered. I had to scrape the skin of my face with a knife. I also have a granddaughter who is autistic (6yrs old). I am going to try your supplement recommendation. Thank you very much for all that you do. May god bless you and your the work that… Read more »
Gloria Simonot
Gloria Simonot
Trudy, I am pretty sure that I have pyroluria and my psychiatrist wanted lots of tests done. He was from Arizona where there is lots of copper in the soils and suspected HIGH copper, but I am from the prairies in Canada and even though I had been taking HIGH doses of ZINC, my lab tests came back with both the copper and the zinc in the lower part of the range. At one point I did read that taking high Zinc doses could cause a copper deficiency. Because of poor endocrine function and pituitary damage as well as poor… Read more »
Kiyla Fenell
Kiyla Fenell

Trudy,
You really know your stuff! After I have this baby I’m going to have to come see you. I don’t have any of these symptoms except for disliking being seated in a middle of a restaurant!
Kiyla Fenell

Dr. Robert Fenell
Dr. Robert Fenell

Truly impressive information Trudy. Great how you made it easy for someone to identify if they suffer from pyroluria. Thanks Trudy!
Dr. Robert Fenell

Sue Painter
Sue Painter

Wow! This is quite a comprehensive list. Thanks for publicizing a condition that makes people miserable and they don’t even realize what’s going on. Off to take my vitamins!
Sue

Katherine C. H. E.
Katherine C. H. E.

Yow! I must have attracted reading this post today because I can check off most of those symptoms. I, like Lisa, am on my way to the vitamin store! Thanks, Trudy! XO, Katherine

Deb Schmitz
Deb Schmitz

Wow – Sue Painter put this link in her Tuesday Tips newsletter. Not only do I have symptoms, but my sister has even more! I forwarded the link to her. Thanks for sharing this!

Mitch Tublin
Mitch Tublin

Trudy,
Wow! This is a lot to digest. ( oops, sorry about that! )
Usually I just clear up my maladies with my good friend Jack. This is quite a list to review, I will pass it on as there are a few people I know who might be helped by reading it.
Mitch

Carmen@GetOrganized
Carmen@GetOrganized

I checked off 15 for sure! I never knew of pyroluria. I guess this is something that one-a-day vitamins won’t take care of alone, that you need a higher dosage?

Jenny Fenig
Jenny Fenig

Whoa! What a list. I had never heard of this condition before and appreciate you sharing your expertise. Fascinating! I’ve been taking vitamins for a while now (pre- and post-natal) and now I truly realize the importance of continuing! Thanks. You are so knowledgeable!

Kelly
Kelly

I agree with the others — great symptom list.

However, it should be pointed out that several other nutrients are often critically essential when it comes to treating pyroluria — including manganese, niacinamide, magnesium, and sometimes evening primrose oil.

Zinc can deplete manganese, b6 can deplete magnesium, etc…..

More info available w/ a google search. 🙂

Sue
Sue
Trudy – very interested in your questionnaire. I am being tested next week for pyroluria as my holistic doctor says I have many symptoms of this – leaky gut, low zinc levels, anemic, damaged kidneys from Ig A proteins attacking them (gluten free to handle this) thyroid problems etc. Plus getting upset and angry without real reason. All good and makes a lot of sense this could be it. I have been gluten free for over a year which has made a huge difference but not resolved gut issues and sleep issues etc. Have been working for over 30 years… Read more »
Sue
Sue

Thanks Trudy and we went to see our holistic GP and told her our concerns for my daughter and she agreed with your comments above on tests needed so we are now organizing them to be done over the next 1-2 weeks. She is also having an IV Vitamin C, Vitamin B right now so that will also get her doing better while we sort the real cause of the problem. She is getting the pyroluria test as well.
Thanks again.
Sue

Gloria Simonot
Gloria Simonot

Sue,
If you and your daughter are having possible thyroid problems it is often helpful to make sure to also get the Free T4 and Free T3 tests along with the TSH (the pituitary hormone that stimulates the thyroid to work). And the levels for the Frees should ideally be in a similar level in their ranges and somewhere around the middle or a little above.

Kay
Kay

Thanks for this great info. I live in a rural area, and I’m having the worst time finding a practitioner near me, along the lines of what you do. I’ve searched holistic directors, etc. I’m willing to work with someone long-distance (online) if need be. I love your book, but I find that I really want and need someone to help walk me through it. When you’re dealing with possible pyroluria, all the attendant symptoms and issues, self-treatment is a major hurdle. Any advice? Thank you, thank you!

Anna
Anna

Hi, both my son and I have been diagnosed with Pyroluria .
I have read that primrose oil (omega 6) should be taken instead
of fish oils (omega 3). Can you tell me the benefits primrose oil
will give us.
Cheers Anna

amar singh turban
amar singh turban

natural things like wheatgrass retention enemas at night for magnesium deficiency and pumpkin juice or checkens feet meat for zinc deficiency and potatoes for vitamin b6 issues and primrose oil remains unchanged ricebran oil and brazil nuts for vitamin e and selenium deficiency hope these help can take more of them if u prefer

Val
Val
Trudy, Thank you for publishing this questionnaire, I haven’t read your book but I do intend to. I’ve been diagnosed with pyroluria and I’m taking Super Nu-Thera which contains P5P. I also need to take extra zinc. Do you recommend a particular type? Like piccolinate or chelate? Also some experts say dont ever take zinc without copper as it causes an imbalance which can be dangerous to the body, but you say to make sure the zinc supplement doesnt contain copper. I am glad i read this as I was about to purchase Now Foods L-Optizinc which has copper in… Read more »
Val
Val
Hi Trudy, Thanks for your answer, the Super Nu Thera tub that I have here has only 25 mg B6 (Pyrodoxine HCL) (1250% Daily value), but I take 4 a day. Also it states at end that it contains P5P 25 mg. Anyway, I do need to return to my practitioner to tell her that it doesnt seem to be helping as yet. Maybe i need more time. She also prescribed Nature’s Plus Candida Forte, which has 50 mg B6 in it, and 50mg of Zinc (Ascorbate) per 2 capsules. I think the doses are high enough, but it could… Read more »
kelly
kelly

Hi Trudy,
Thanks for all the great info. My dad and I were both just diagnosed with Pyrolurria.
I am wondering how much evening primrose, zinc and P5P I should take a day?
I live in rural Mexico so its not very easy to get medical testing done.
Could you recomend a daily dosis to start with??
Thank you, Kelly

Jacob
Jacob

Hi Trudy
My name is Kuba.I am from Poland.I recently tested positive for pyroluria in KEAC lab in Netherlands.They send me results and suggested to buy Depyrrol basic.Here,s information:
Depyrrol basic
One jar contains 60 vegicapsules. Two capsules provide: Pyridoxal-5′-Phosphate (P5P) 50 mg (elemental 33,5 mg Vit. B6) 1.675% RDA; Pyridoxine-HCL 10 mg (elemental 8.2 mg Vit. B6) 410 % RDA; Zinc Gluconate 210,5 mg (elemental 28,5 mg Zinc) 190 % RDA; Manganese Gluconate 41.7 mg (elemental 4.8 mg Manganese) 96 % RDA.

What do you think about this product?Do you think it would be better to take each supplement separately?

Amy
Amy
Dear Trudy, I just picked up your book (The Anti-anxiety Food Solution) a couple of days ago and can’t put it down! I feel as though you were speaking to me re: Pyroluria! I’ve been going crazy the past 3 years trying to find answers for my daughter. She is now 11, but has struggled with anxiety, depression, obesity, etc etc etc since she was 8. I am from a family of 3 girls, a Mom & Dad. My Mom, adult sisters, Aunt, female adult cousins, and myself (I am 41), are ALL on anti-depressants. (My Mom also has Celiac’s… Read more »
Amy
Amy
Thanks, Trudy for getting back to me! If there isn’t an actual “test” for Pyroluria, can we at least be tested for possible low B6 and low zinc, as a guidance for what our blood may be lacking?? Maybe check for possible low iron as well? I will definitely bring your book with me to our appointment, but I want to make sure I insist on the certain blood work that I should have tested on my daughter. I don’t want ANYTHING to be overlooked!! Oh, and I’d LOVE to hear you speak! I’ll have to mark my calendar and… Read more »
Rob
Rob

Hi Trudy,

I just recently stumbled across pyroluria as a possible diagnosis for my symptoms. I do have many of the symptoms listed. In my expierence, antidepressants only make my symptoms worse, and antipsychotics provide little to no relief. I do have a history of mental health issues in my family. Also, I have been tested for everything including thyroid, adrenals, b-vitamins, and everything checks back normal. Ive also tried every supplement except b6 and zinc with no success. Is psychosis part of pyroluria? Any suggestings if I should start taking zinc and b-6? Thanks in advance! Rob

Rob
Rob

Thanks Trudy! Any suggestions on how much to start with? Im getting bloodwork done tomorrow to test zinc and copper levels, so hopefully I have something gauge with.

Jacob
Jacob
Hi Trudy! I started taking pyroluria supplements two days ago.I take: Zinc picolinate 50mg p5p 50mg b6 100mg manganese 5mg EPO 1000mg Vit.C 2000mg B5 1000mg I know i started with higher doses than you recommend but on the other hand in Depression Free Naturally i found formula with even higher doses.I’m gonna try my regimen for about two weeks and see if i improve.Do You have any suggestions about this? I also have several other issues like type III allergies(gluten,eggs,diary and several others),sugar imbalances,lots of nutrient deficiencies(i’ve done hair mineral analysis).I didn’t test my histamine level but i’m 95%… Read more »
HipGrrrrl
HipGrrrrl
I’ve had some suspicions about my family and pyroluria. I have three siblings, two of which are girls (three girls, one boy). We have a resemblence, but do not look remarkably alike. My mother (who probably meets most, if not all, of the criteria for pyroluria) comes from a family of five siblings (four girls, one boy) but the girls do not look alike – well, aside from the set of identical twins, that is. Interestingly, I have read (Carl Pfifer) that boys in pyroluric families tend to have deformity and both my maternal uncle and my brother have had… Read more »
Ruby
Ruby
HI Trudy, I just came accross this site by accident and i am so happy i did! I just checked 19 of these symptoms! OMG…I never knew there was a name for what i feel..ie anxious, hating to be center of anything, panic attacks, constipation, dislike of criticisms…poor self image, insecurity (thats not on the list i know) and so on…i also have the strech marks and the white marks on nails and creaking joints etc… anyway i recently purchased zinc (gluconate) 50mg (becasue someone told me it may help with strechmarks which ive been trying to get rid of… Read more »
Linda bowers
Linda bowers

Do you do zinc hair test or know who does. how much cost or take medicare I am in dexter ME

Nancy
Nancy
I have read alot of your site about pyroluria and am going to the store now to buy the supplements. I am having trouble finding the liquid zinc sulfate at the health food stores and at the ND dr. office. One store has a lizuid zinc by Trace Minterals that also has magnesim, copper, chloride, suilfate and a little boron. Can we use this one to do the zinc tast test? Also they have a bazillion brands for the evening primrose oil. Do you recommend any over another? They told me the Now brand was a good value. Thank you… Read more »
Debra
Debra

Just got the B6, Opti zinc and evening primrose…scored 21 on the pyroluria questionnaire. Thank you for providing a starting dose. Feel sure this is my problem and hope I can get off my anti depressant. Went to my psych the other day told him all was fine, since I lost my job MUCH less stress and anxiety. His reply was that he thought I should up my dose of my anti depressant! It was if he wasn’t even listening to me!

Melissa
Melissa

I was wondering if you could explain why a zinc supplement without copper is recommended. I thought they had to go together.

Dan
Dan
Hello, I”ve been considering getting tested for pyroluria for years now, but being on medicaid, and being sick (w/CFS), has prevented me financially, but also brain-fog-wise, from getting the test done so far. But after reading about this (once again), I’m going to try to find an inexpensive test that hopefully can be done without a doctor’s visit. I did have a Spectracell nutrient profile done about 9 months ago, and that showed all my “B’s” were borderline (except for b12) and my zinc and vitamin D were considered “deficient”. But here’s my question: I seem to be intolerant to… Read more »
Kuba
Kuba

Hi Trudy!
I’ve got a question about Nutritional Balancing Program.What do You think about it?Would You recomend it for a copper toxic person?I’ve also got a Calcium Shell patern on my HMA.Would you recomend NB for me?

Thank You

Dan
Dan
Thanks for your reply Trudy — and so sorry for my late reply. It has been awhile since I tried b6 or p5p, so I guess I could try it again in tiny doses. I did use reputable brands last time — probably Thorne, but maybe didn’t have enough of other co-factors at the time. I read on another forum where quite a few people could not tolerate any b6, and on another forum where a woman had high serum b6 and found that by increasing her b12 considerably, she was finally able to lower the b6 and then later… Read more »
Tanya
Tanya

Hi Trudy,
Thanks for your webpage!
Five months ago I found out I am c677t hetero, I have been taking a heap of suppliments for it (L5 Metafolin, B12, fish oil, Thorne prenatal, CoQH, vitD)- I have just been diagnosed with Pyroluria (due to more tests after another miscarriage). Can Pyroluria contribute to miscarriage? Is there a safe amount of zinc and b6 during pregnancy if one has Pyroluria?

tracey
tracey

Hi Trudy

I am in Australia and have scored quite high on your questionnaire.
I will begin on the doses of B6, zinc and EVO that you recommended to start on but am wondering how to proceed.

You don’t suggest taking the pyroluria test but I wonder if there are tests I should take to determine my deficiencies etc.

I have been trying to correct hypochloridia, hair loss and adrenal fatigue for quite some time and suspect my lack of progress is due to pyroluria.

Any info you can offer would be appreciated.

Tracey – Oz

Jenny
Jenny
Hi Trudy – thanks for this webpage and info – fascinating. Ive been strggling with health issues (22 of the most common pyroluria symptoms listed) for over 18 years.(im 46) Anxiety being the biggest battle. I have always felt there has been a ‘biological’ cause. Ive been researching more of late as I am seeing similar problems in family children (mine and nieces and nephews)and dont want them to experience what Ive been through. Ive noticed in previous posts that you suggest not doing the pyroluria test. Why is this? is it not a reliable test? What if test comes… Read more »
Jenny
Jenny

Thanks Trudy! Appreciate your time and response. 🙂 Jenny

Lisa
Lisa
Hi Trudy, Two weeks ago, my 10 year old daughter was diagnosed with pyroluria (through urine testing). She has been suffering for about a year with acute anxiety attacks that came out of no where and always after an illness. We sought out therapy and were prescribed anti anxiety medicines. My daughter would be great for about 2 to 3 months and then the anxiety would strike again with a vengence and always after an illness. My daughter has many of the symptons on the list. The lack of morning appetite, extremely pale, etc. I have also seen documented that… Read more »
Angela
Angela
Dear Trudy, I am a nutritionist with interest in the same area. I am happy that we have discovered this tremendous public health issue and an easy “cure” (affordable, etc.) and yet my mind wanders to underlying causes and the need to pay attention to these. Treating with vitamins is better than most chemical medicine “cures” that mask symptoms, but perhaps not digging deep enough. My guess is this is a relatively modern syndrome resulting from contaminants (pesticides and hard metals or inability for body and brain to detox) – hitting against an older set of antagonists, that our bodies… Read more »
Melissa
Melissa

Hi Trudy, I have had bad inner tension most of my life but great dream recall. Does this mean that I am probably not pyroluric?

Susan Michele
Susan Michele

It would be easier to list the symptoms I don’t have! I am shocked. In the past, I’ve received weekly vitamin IVs but that doctor moved home which is about 5 hours from me. Zinc and B vitamins were among the contents of the IV. I need to do that again! Thank you for the info.

Samia
Samia

Boy, this is a good place to go to for practical informtion! You are most kind. I don’t have pyro but am in charge of someone who might (boy). One question: Your recommended starting amounts of supplements – is this the total for the whole day, or the dosage to be taken 2 or 3 times per day? Also, I hope your advice isn’t only for females. Many, many thanks & blessings. – Samia. P.S. Is more (supplementation) better or could it have a negative effect?

Kate
Kate
What an informative blog Trudy – there seems to be an increasing number of people diagnosed with this condition but very little authority on the best approach. Having been diagnosed via a bloodtest with Pyroluria I went on high dosage supplements for 4 mths, after which I came off as they were really expensive plus my local GP felt the body corrects itself after 3mths. I have since had a blood test for zinc which was on the low side – naturopath said too low, GP said normal. So my question would be, should we remain on supplements indefinitely? I… Read more »
Kate
Kate
I had a blood test measuring levels of HPL in urine – done through an analytical lab here in Australia (through a biomedic). I was put on 250 Pyridoxine B6, 50 Pyridxal 5 Phosphate, 200 Vit E and 1000 Biotin for day time and 1000 Vit C, 70 Zinc, 200 Vit E and 1000 Biotin at night – all done through a compounding pharmacy (hence cost I guess!). Also take Evening Primrose Oil. I had a recent zinc blood test which although on paper is within range, I now take a zinc drink at night and it tastes like elderflower,… Read more »
Kate
Kate
Paula
Paula
Hi Trudy, I’ve been researching pyroluria and most information on the internet, including blogs of several alternative doctors, warn not to self treat due to the side effects of high b6 (neuropathy) and zinc (possible copper detox symptoms and/or copper deficiency). I’m curious as to why so many practitioners guard against these side effects as my understanding is neuropathy is reversible and zinc toxicity/detox symptoms, shouldn’t occur if you go slowly. What would you consider a safe upper limit for b6 and zinc? I’ve read up to 2,000mg total b6/p5p (Depression Free Naturally) and 60mg of zinc would probably be… Read more »
Paula
Paula
Hi Trudy, I think those are her starting doses. On page 154 of Depression Free Naturally (google books preview) there is a list of supplements for pyroluria. B6 has an asterisk next to it and if you go to the bottom of the page it says to “Adjust B6 until you can recall your last dream before waking. Do no exceed 2,000mg of B6/P5P combined.” This is where I’m a little confused, as I know those are considered very high doses of B6. I think I’ll play it safe and follow your recommendations for 500mg B6/100 mg P5P maximums. Thanks… Read more »
alison fisher
alison fisher
I have been suffering with a variety of symptoms for years. I came across your site and realised after checking the symptom list I could have pyroluria. I sent a urine test to bio lab and it has come back with elevated kryptopyrroles. However blood tests for zinc and b6 are said to be normal. My GP doesnt know what to do he is at a loss, the gastroenterologist is not interested I live in the UK. I would like to start supplements but am not sure what dosage, can you help. This has been going on now for 6… Read more »
Brandon
Brandon

Hi Trudy,

I have been diagnosed with Low T ( testosterone, I’m borderline but its still considered to be low ). I also have a lot of the symptoms listed for pyroluria. I think i scored a 40 on your questionaire. My question is could pyroluria lead or be the cause of my low T? I’m just trying to make sure I’m treating the root cause and not band-aiding the symptoms. Thanks

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