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GABA for bladder pain/interstitial cystitis and urgency, IBS pain and anxiety?

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gaba for pain

Is there a place for using the amino acid GABA as a supplement to help with bladder pain/interstitial cystitis and urgency and also help with IBS (irritable bowel syndrome) pain – at the same time as easing physical anxiety caused by low GABA levels?

I’d like to share some quotes from this commentary, GABAB receptors in the bladder and bowel: therapeutic potential for positive allosteric modulators?

The bladder pain syndrome (or interstitial cystitis/painful bladder syndrome) is a spectrum of urological symptoms characterized by frequency, urgency and pain on bladder filling.

Bladder pain syndrome is often present in those who have IBS and abdominal pain and the authors mention the role of GABA in both:

Of further note is the co-morbidity between bladder pain syndrome and other functional pain syndromes, in particular, irritable bowel syndrome, a functional gastrointestinal disorder associated with visceral abdominal pain and altered bowel habit.

… it is tempting to speculate that GABAB receptor positive allosteric modulators may display efficacy in not only functional pain disorders of the bladder, but also of the bowel, through modulation of either central and peripheral GABAB receptors, or both

Positive allosteric modulators increase the activity of the receptor so in this case they are referring to increasing the activity of the GABAB receptor, reducing both bladder pain and gut pain.

This commentary and the original paper refer to ADX71441, which has been shown in animal studies to be “a novel positive allosteric modulator (PAM) of the GABAB receptor that has shown encouraging results in pre-clinical models of anxiety, pain, overactive bladder and alcohol addiction.”

We know GABA eases anxiety and pain and is extremely beneficial when it comes to alcohol and other addictions. In a recent blog post I shared how PharmaGABA eases physical anxiety in a young man who has recently given up Adderall, alcohol and nicotine.

And given that depression, anxiety and stress is higher in women with urinary incontinence it makes sense that an amino acid such as GABA may also help ease some of the symptoms of bladder pain syndrome when low GABA is a factor.

Depending on the root cause/s it’s likely addressing low serotonin, low endorphins and low vitamin D may play a role too. Of course, a full functional medicine and nutritional work up and review of diet is key too. Bladder dysfunction is seen in up to one third of celiac patients. This can cause leaky gut and nutritional deficiencies leading to low levels of neurotransmitters such a GABA and serotonin. Dietary oxalates can often be a factor with bladder issues and pain.

Considering all of this in conjunction with learning from/working with a pelvic floor physical therapist is key.  I highly recommend someone like Isa Herrera, MSPT, CSCS who hosts online masterclass training sessions for those with pelvic health issues. Her next series airs online mid-February and you can learn more and register here.

Here are some related blog posts that you may find helpful:

In case you’re new to GABA you can read more about it here: GABA for the physical-tension and stiff-and-tense-muscles type of anxiety.

The supplements blog lists GABA products I use with clients and recommend to those in my community.

I’m proposing that there is a place for doing a trial of the amino acid GABA (as a supplement) to help with bladder pain/interstitial cystitis and urgency, especially when there are symptoms of low GABA. If GABA helps to ease the visceral pain caused by IBS/SIBO, it may also help with bladder pain.

Have you observed less bladder pain when using GABA for easing physical symptoms of low GABA anxiety (stiff and tense muscles, overwhelm, lying awake tensely at night, anxious and using alcohol to self-medicate in order to calm down)?

Have you noticed any reduction in bladder urgency when using GABA for anxiety?

Do you also have IBS pain or SIBO (small intestinal bacterial overgrowth) pain that is eased by GABA?

Have the following helped: going gluten-free, lowering oxalates and/or working with a pelvic floor physical therapist?

If you’re a practitioner have you made any of these observations?

Please do share in the comments below and let me know if you found this helpful, what else has helped you or if you have questions.

Digital Dementia: Addiction, brain chemical imbalances, suicide and low-level lasers for healing

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digital dementia

“Digital dementia” is very real – overconsumption of screen time can lead to a breakdown of cognitive abilities and deteriorated posture, developmental delays, degraded short-term memory, seclusion and lack of motivation… especially for our children!

In my interview, Food and Mood Support to Prevent Digital Dementia, I talk about anxiety, depression and even a higher risk for suicide in overuse of screen time and how using diet and amino acids can help with the addiction and related mood issues.

krista and trudy

One of the questions Krista asks is this: “What do you think will happen to children/teens if we don’t make changes as a society?” and I share some scary stats about suicide.

In a 2018 article in Newsweek, “iPhones Pose Suicide Risk to Teenagers, Apple Investors Warn”, they share

A 2017 study by Jean Twenge, a professor of psychology at San Diego State University, who found that U.S. teenagers who spend more than three hours a day using electronic devices are 35 percent more likely to have a risk factor for suicide than those who spend less than an hour.

Teenagers who spend more than five hours on their phones are 71 percent more likely to have a risk factor for suicide.

And these are very real and sobering stats about the average American teenager – they first receive a smartphone at the age of 10 and spend over 4.5 hours a day using it!

Of course, we have to consider how much is it the biological effects of the smartphone itself (DNA damage, immune system effects, depletion of zinc and melatonin etc.) and how much is it the poor nutrient status and brain chemical imbalances that are driving this high use of smartphones (i.e. a need to self-medicate by going online) and the increased anxiety, depression and suicide risk?

It’s likely a combination of both…and a vicious cycle that can be broken with education AND addressing brain chemical imbalances. Low GABA, low serotonin, low dopamine and even low endorphins drive teens (and us adults too) to “self-medicate” with social media and iPhone use in order to feel calm, happier, stimulated and/or comforted.

We do this just like we do with sugar, street drugs, prescription pain meds, and alcohol. Just like with drugs and carbs, we can break this very serious digital addiction with individual amino acids such as GABA, tryptophan, DPA and tyrosine, and prevent digital dementia AND improve the mood and reduce the anxiety of those experiencing this. It’s imperative we use this approach in addition to dietary changes, parenting tips and education about this harm we’re doing to ourselves.

The good news is, that in addition to improving diet and nutrient status, we can also use tools to help with healing.

Kirk Gair, DC, in his interview, Lasers – Secret Weapon Against Digital Dementia, covers benefits of low-level lasers (also called photobiomodulation) for brain support and it’s fascinating. Here are a few snippets from his interview:

  • The main target area is going to be in what’s called the powerhouse or the mitochondria. They’re going to absorb the energy from the laser, and they’re going to make more ATP, which is an energy molecule that helps basically every process in the body; whether it’s your brain firing, whether it’s sports performance, or whether it’s healing tissue, you’re going to see that increased.
  • You’re also going to make something called “nitric oxide,” which dilates the blood vessels. Especially when we look at the brain, that’s really important. We dilate these blood vessels. You’re going to improve blood flow throughout the brain.
  • You’re also going to stimulate glutathione, which is a powerful antioxidant that helps to neutralize damaging free radicals, which we know can affect the aging process, can turn on different kinds of genes in our DNA, etc.
  • Numerous studies have shown the lasers being able to actually calm down autoimmunity, especially with thyroid antibodies. It’s been shown to be able to decrease those TPO antibodies, which then protects the cerebellum.
  • If we’re looking at an athlete who’s been concussed, or just a regular patient who’s had a car accident or a fall or something, the laser has been shown to be able to modulate the immune system so it knows which cells to clean up.

Learn all this and more on The Digital Dementia Summit

digital dementia summit

Host, Dr. Krista Burns, is an author and speaker who has been educating practitioners about the dangers of digital dementia for over 5 years. With this summit she believes it’s now time to reach parents directly for their health and that of their children.

Sweet Freedom Summit: industry manipulation, mouth feel and vanishing caloric density

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The Sweet Freedom Summit runs April 10-17. I like to do a sneak preview of some of the interviews so I can share some highlights with you and I was blown away by some of what I learned from Damon Gameau, Australian actor and producer of That Sugar Film.

His interview: The Real Dope on Added Sugars. We know this goes on but every time I hear it I feel mad (and a bit sad) that it happens and that it’s actually allowed to happen! And that so few people even know about this! Here goes:

Nestlé, for example, have about seven hundred PhD scientists just working on their foods and understanding what the mouth feel of the food is that makes us really like them or how it triggers certain parts of our brain and releases dopamine that makes us want more.

People often talk about, “It’s freedom of choice. People should be able to decide what they want.” But that’s fair enough if you understand the playing field and it’s a very one-sided playing field because these foods are being engineered to get you liking and wanting more and more of them. So, it is very hard for some people to say no to things.

This term was new to me: vanishing caloric density!

There is a great term I learned for those kind of—we have them in Australia—they are called Cheetos or Puffs where you have them and they feel like they turn to air in your mouth very quickly. It’s called vanishing caloric density. It means that you don’t feel like you are eating much. So, you can just sit there and watch TV and demolish an entire bag because it’s tricking your brain into thinking that you are actually not eating very much because they are disappearing in your mouth. So these have been designed this way, very carefully so that they’ll sell more of those products.

Damon is shocked by the manipulation and so should we all be!

That probably shocked me in terms of the manipulation there. And just to start to understand the level of rigging of science, the paid scientists, the PR companies that are pushing the food industry’s brand, how they attack certain groups in social media; just the sort of orchestration that these companies use to make sure that there is ambiguity and doubt in the public mind.

Damon’s interview airs on day 1 and not to be missed. Be sure to listen to the entire interview! You won’t believe what he did to himself in That Sugar Film! (hint: he embarked on a unique experiment to document the effects of a high sugar diet on a healthy body, consuming only foods that are commonly perceived, or promoted to be ‘healthy’.)

On day 1 you can also hear Jonathan Landsman (what sugar does in your body), JJ Virgin (sugar’s full impact) and Ty Bollinger (sugar-cancer connection).

The first step is awareness and knowing where sugar is found – this is covered extensively during the summit.

The next step is switching to a real whole foods diet with quality animal protein (I’m not a fan of a vegetarian diet – covered by one of the speakers) and healthy fats, organic produce and no sugar.

This is easier said than done for many people. You may know you need to quit sugar but willpower gets the better of you. If this sounds like you be sure to tune in to my interview.

In case you missed it, a few weeks ago I shared some snippets from my brain chemical/neurotransmitter imbalance interview with Sherry – addressing sugar cravings as well as anxiety and depression. I talk about the BIG connection between stress eating, comfort eating, emotional eating and low levels of the brain chemicals serotonin, GABA and endorphins.

Sherry loved our interview so much she’s decided to offer it as a gift to EVERYONE who signs up for the summit! So you can enjoy it from day 1 or tune in and comment when it airs.

The Sweet Freedom Summit runs April 10-17 and when you register you’ll get immediate access to my interview and some other cool sign up gifs.

Please share with family and friends who you know can benefit from this information!

Got questions or feedback? Please share them in the blog comments below.

The Anxiety Summit: The Addicted Brain and How to Break Free

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HylaCass2

[REPLAY on Monday 6/23 – ENJOY!]

This is day 6 of the Anxiety Summit.  Dr. Hyla Cass, M.D. board-certified in psychiatry and integrative medicine and the author of Natural Highs and The Addicted Brain and How to Break Free, is interviewed by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

The Addicted Brain and How to Break Free

  • how to recognize the signs of addiction
  • why do we become addicted and what is the connection to anxiety
  • food/carbs/sugar, caffeine, alcohol and drug addictions
  • how can we end addiction without suffering/withdrawal

Here are some great gems from my interview with Hyla:

in order to make neurotransmitters/brain chemicals that send messages around in our brain, we need the right raw materials

I think the personality becomes addictive because of this imbalanced neurochemistry

I’ve had people sent to me, for example, with anxiety, and it turned out that what was really going on was they were consuming aspartame in their soft drinks

If someone has anxiety, it’s not a Valium or a Xanax deficiency. It could be a GABA deficiency

Low serotonin leads to increased appetite, really craving carbs, feeling depressed, anxious and irritable, and having trouble sleeping

the food industry feeds off us as we’re feeding off of all that junk

This whole idea of a pill for every pill is just wrong

Hyla shared how Dr. Davidson, a conventional psychiatrist from Duke University, discovered that with atypical depression, there were people who were totally unresponsive to the drugs i.e. – nothing worked. He found that those patients did really well with chromium. Here is an article on the Psychology Today blog on chromium for depression.

And here is Hyla’s Huffpo blog post on Is it drugs not guns

Here are two of Hyla’s great books:

Natural Highs: Supplements, Nutrition, and Mind-Body Techniques to Help You Feel Good All the Time

Eight Weeks to Vibrant Health: A Take Charge Plan for Women to Correct Imbalances, Reclaim Energy and Restore Well-Being

Get your free gifts from Dr. Hyla Cass: “Outsmart Your Addiction Quiz” and “Reclaim Your Brain” e-report

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here www.theAnxietySummit.com

UPDATE: the summit concluded on Tues 6/24 – season 2 of The Anxiety Summit will be in November 2014. If you’d like to be on the notification list just sign up here www.theAnxietySummit.com

Missed this interview or can’t listen live? Or want this and the other great interviews for your learning library? Purchase the MP3s or MP3s + transcripts + interview highlights and listen when it suits you

No sugar or sugar in moderation? I say NO sugar!

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Delicious Chocolate Cake

More and more research is supporting the fact that sugar and carbs are as addicting as drugs and as difficult to quit for some people. I came across this quote the other day: “Stressed spelled backwards is desserts. Coincidence? I think not!” and it’s perfect. We crave sugar because we are stressed, sad, looking for pleasure and for energy and motivation. And we self-medicate with it in the same way as drugs, caffeine and tobacco.

This paper called Obesity: The emerging neurobiology of calorie addiction was published just a few days ago:

“The increased availability and consumption of highly palatable foods is the major factor behind the rise of obesity and type 2 diabetes in developed countries.”

“Progress has been made in recent years in understanding the neurobiological underpinnings for this preference” for sucrose: “sucrose activates dopamine neurons in a region of the brain called the striatum, and the resulting release of dopamine is associated with pleasure.”

“Moreover, the repeated consumption of high levels of sucrose can create a cycle of continued overconsumption—even compulsive eating—in order to recapture the initial feelings of pleasure. This is similar in many ways to drug abuse or addiction, and also involves some of the same signalling pathways within the body”

This dopamine/pleasure mechanism is just one way that leads to sugar addiction. This Oct 2013 paper in Nutrition, Neurobiologic basis of craving for carbohydrates says this:

“There is a relationship between emotional disorders, obesity, and craving for carbohydrates”

“Research on the basis of carbohydrate craving is varied, but may be grouped into five main areas: the serotonergic system, palatability and hedonic response [i.e. pleasure], the motivational system, stress response systems, and gene-environment interaction”

Last week I posed this question on my facebook page: “no sugar or sugar in moderation? what’s your vote? I say NO sugar! Do you think that’s too harsh and too unrealistic?” I was referring to ANY sweetener other than fresh fruit.

Here are some of the comments my tribe offered:

  • I’d say in moderation. However I’m trying to reduce my view of moderation over time.”
  • I was totally sweetener-free for a long time so I know how that feels for me. I’ve been experimenting with raw honey I seem to do fine with it “in moderation” (i.e. even a little bit each day is fine – although I don’t make baked goods so I’m not using large quantities.)
  • I seem at present to be incapable of moderation with sugar. So for me none at all might be the way I need to go. Humans developed over many thousands of years with just the sweetness of unprocessed fruits and maybe some honey now and then. Our culture’s idea of what “moderate” even means in regards to processed sugars is highly skewed.
  • Zero is way too hard for me but everyone is different
  • I say: a little bit of everything is just perfect!
  • Zero sugar is too rigid for me…I don’t think any of my clients say no to sugar 100%…I do avoid white and brown processed sugar ~95% of the time but will eat it when at someone’s home made with love. Every day, I use maple syrup to sweeten teas and in baked goods.
  • I don’t think a little bit of natural sugar is bad at all; but only just a little bit.
  • I’d say it’s ok for someone else [the zero sugar]! For me, I have to have a little here and there – just like bread. However, it’s a fraction of what it used to be. Maybe at some point I can whittle down from there.

Very few agreed with me about zero sugar. Here is what they said:

  • I’m with you! it is realistic as I have given up sugar and all artificial sweeteners.
  • NO sugar – Dr so astounded that I’ve brought my numbers down so much after wanting to give me meds for years. She said no meds would’ve brought my numbers down as much as I’ve done with diet and especially NO sugar or carbs.

Here are some of my thoughts: “Moderation” has quite a big range for some people and I see it going out of the window when it comes to baked goods. I see many recipes calling for pretty large amounts of maple syrup of honey. I recently heard Tana Amen, BSN, RN and author of The Omni Diet speak about sugar and crack cocaine in the same sentence and she said: “they are both addicting. We’d never do crack in moderation so why do sugar in moderation!?” I agree!

A friend and I were at a recent celiac function that had tons of gluten-free treats – all loaded with carbs and sugar and not healthy at all even though they were gluten-free. We had no desire to have any of the treats. That’s how we should feel! Zero sugar should be easy!

You won’t crave sugar or even feel the need for a little bit or an occasional treat if you have balanced biochemistry and are not stressed, no nutritional deficiencies (low zinc can be a factor) and are eating to control blood sugar.

You won’t be defensive when asked about it and you won’t feel deprived when you do go without it. You won’t feel that you need just a little. You also won’t have to white-knuckle it and use willpower.

Where do you stand? No sugar or sugar in moderation? And do you think that zero sugar is too harsh and too unrealistic? Do you think addiction plays a role? Are you white-knuckling it or can you take it or leave it?

Do you need help to get to zero sugar consumption? Here are some resources for you.

  1. Check out these chapters in my book “The Antianxiety Food Solution: How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings”: eat real food, blood sugar balancing and the amazing amino acids.
  2. Stay tuned for the upcoming release of my homestudy program “Amazing Amino Acids for Emotional Eating.” Listen to me present on upcoming calls and tele-summits as I share some of the highlights of this wonderful 6 week program.