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GABA is calming for me, doesn’t work for my daughter’s anxiety and makes my son sleepy

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I’m sharing this question I received on my GABA Calm blog to illustrate how different people respond to GABA and how some people may not even have the low GABA type of anxiety. Here is the question this mom posted:

I have used GABA (several brands, just open capsule and sprinkle small amount under tongue) for years now, with calming results within minutes. It was recommended to me by 2 family members, both bi-polar, who were tested by Dr. Amen. I have also used it with my children (now adults); my daughter says it doesn’t work for her. (She has anxiety issues and occasional panic attacks, and Rescue Remedy helps her.) It does work to calm my 3 sons, but one says it makes him sleepy, and lasts into the next day, so he won’t take it. Trudy, have you heard of this reaction? It seems extreme for such a small amount used. He is a college student and ‘medicates’ with caffeine, if that makes a difference.

She shared that she uses 500mg or 750mg capsules of GABA, and get several doses from a single cap (so maybe 100mg per dose).

This is what I shared with her: we are all biochemically different and one form of GABA (or GABA combined with other amino acids/nutrients such as GABA Calm) may work for one person and not another. Also one person may need more and another may do fine with much much less. Also anxiety has many underlying causes, with low GABA only being one of them.

If I was working with your daughter I’d have her trial higher amounts of GABA for the anxiety and panic attacks. I’d also look into low serotonin and a trial of tryptophan too especially if her anxiety is the worry, ruminating anxiety with insomnia and the blues, with increased afternoon and evening cravings for carbs and chocolates.

If I was working with your son, because it does work to calm him, I’d start by having him trial just 25mg of GABA and increase slowly from there, monitoring how he feels. His anxiety may also be related to his caffeine consumption – which can also affect sleep and the fatigue he feels in the morning could be related to that.

Note: She did ask this question on the GABA Calm blog and was planning to have them trial this form of GABA. I typically don’t have clients use GABA Calm at night (because of the tyrosine) but it’s certainly worth a trial especially with her son.

If you’re completely new to the amino acids for anxiety here is an overview with questionnaire, precautions and how to do a trial.

Depression as a black dog that comes in and lays down beside you at night

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Trevor King’s interview about his journey with depression – on That Vitamin Summit – is not to be missed if you are depressed, have ever suffered with depression or if you have a loved one or friend with depression. He shares how he feels a sense of complete hopelessness at times:

It descends like a black cloud that makes me almost sort of retreat into myself. And my eyes will know and I don’t want to take the world in. I don’t want to get out of bed at times. Actually, that’s one of the things that … one of the only things that actually helps me, is going to bed and lying down.

Winston Churchill famously described it as this black dog who’d come in and lay beside him at night.

“From the moment my eyes opened in the morning, I am engaged in a battle. I must protect myself with armor against ongoing, negative, intrusive thoughts that flood into my brain, while sending my prefrontal cortex, which is the home of logical thought, the green light to make decisions and take charge of my brain’s limbic system. That is, before the fear center completely spazzes out. I spend more time and energy chasing and maintaining good health than I do in any other aspect of my life. My marriage, family or work. Because I know that everything meaningful and good around me depends on a stable base. And I hope and pray that one day, I don’t have to fight so hard for my sanity.”

He talks about how he is affected by sugar and low blood sugar, and how he’s found some benefits with niacin, chromium, magnesium and tryptophan (when he’s consistent with taking them!).

Trevor actually talks about the GABA interview I did with him a few days earlier and how he’s very interested in what he learned. He is planning to do a trial of GABA to see if it can help him further.

Here is a snippet from my interview on GABA (so do tune in to this interview if you’re new to my work and the targeted amino acids):

GABA is really quite profound. When I had my anxiety, GABA was my lifesaver. It completely turned my life around. Within three days of using GABA, the panic attacks stopped and the anxiety started to go down, and then I had to look for all the other root causes. It worked immediately so I’m a complete believer, just because I’ve experienced it myself. You’ll hear a lot of people say GABA won’t work. It doesn’t cross the blood/brain barrier so it’s not going to have an impact.

We’ve now got research showing that there may be ways that it crosses the blood/brain barrier. We’ve also got research showing that we have GABA receptors in various parts of our body. We’ve got a lot in our muscles, and with low GABA symptoms you’ll have physical tension.

The beautiful thing is it works. It works quickly, and if you have these low GABA symptoms, which is the physical anxiety, which could be panic attacks. It could be stress eating, it could be drinking to calm down. If you are the kind of person who needs wine to wind down at the end of the day, that’s a big sign that you may need GABA. You take the GABA and you just feel this physical tension release from you, you know you’re onto something good.

I just wish I’d known about his struggles with depression at the time of our interview – I would have talked more about tyrosine for dopamine support (for curl up in bed depression) and DPA for endorphin boosting (for low endorphins weepy depression). 

I did discuss gluten and would consider this especially since his daughter has issues with it. I talked about low serotonin and mentioned Lidtke tryptophan.  If someone doesn’t do well on another brand I’d have them trial the Lidtke brand.  I’d also look into SIBO – I have SIBO and rice and grains make me feel flat and low and I see this often with clients.  Finally I’d look into lithium orotate for keeping an even mood. 

Trevor shares these wise words at the end of his interview:

You do find that when you actually bite the bullet and share it with people,

people are very, very understanding. And actually, you’re amazed that many people have been there themselves.

I could not agree more which is why I’ve always shared my journey with anxiety. I appreciate him for being willing to share his story with depression!

If you’re not already registered here is the registration link for That Vitamin Summit

Feel free to post questions or feedback below – and share your story with anxiety or depression if you feel drawn to do so

GABA protects against hypothyroidism caused by fluoride and reduces anxiety

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GABA (gamma-aminobutyric acid) is a calming amino acid that when taken as a supplement (ideally sublingually) works to relax, calm, ease anxiety and social anxiety, quiet the mind, help with sleeping challenges, reduce neck and other body tension, remove uneasiness and worry, and give hope.

It’s one of the main amino acids I use with my anxious clients and they see great results. We are seeing more and more research that this amino acid does work and yet I still get weekly questions about GABA: “I’ve been told it won’t work unless I have a leaky blood brain barrier.” This is a myth I’m trying to dispel and cover this topic in great detail in my GABA talk on the last Anxiety Summit.

GABA also protects against hypothyroidism caused by fluoride

Because of all this I’m always excited to see new research on the benefits of GABA and this recent study is no exception. It was an animal study and the authors report that GABA also protects against hypothyroidism caused by fluoride: γ-Aminobutyric acid ameliorates fluoride-induced hypothyroidism in male Kunming mice.

The mice that were injected with sodium fluoride were found to have decreased blood levels of T4, T3 and thyroid hormone-binding globulin (TBG) and damage to the thyroid:

fluoride intoxication induced structural abnormalities in thyroid follicles.

The fluoride-exposed mice that were subsequently treated with GABA were found to have improved results for T4, T3 and thyroid hormone-binding globulin (TBG levels) and healing of the structural abnormalities in thyroid follicles that were observed after fluoride exposure.

The authors conclude with this statement, reporting that GABA acted as a natural antioxidant:

To the best of our knowledge, this is the first study to establish the therapeutic efficacy of GABA as a natural antioxidant in inducing thyroprotection against fluoride-induced toxicity.

If you can’t get access to GABA, a paper published earlier this year reports similar results with taurine, an amino acid that promotes GABA production: Taurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluoride.

Added to our water supplies, fluoride affects the thyroid

Although this post is about GABA I recognize that I also have to address the fluoride aspect which I know is a controversial topic! We all know that fluoride has been added to our water supplies in an attempt to try and prevent tooth decay. Izabella Wentz, author of the new book Hashimoto’s Protocol, writes about what she calls the Fluoride Conspiracy:

However, most people don’t know that fluoride was used as an antithyroid drug that suppressed thyroid activity in people with overactive thyroids before the invention of antithyroid drugs.

A dose of 2 to 5 mg per day was typically found to be effective for suppressing an overactive thyroid. If you’re following directions and drinking your eight cups of water each day, chances are, you are taking in enough fluoride to suppress your thyroid if you live in the typical fluoridated community!

While most Westernized countries have rightfully rejected fluoridation without any apparent consequences on tooth decay, the United States, Canada, and parts of the UK continue to fluoridate their water.

In research that was way overdue, a 2015 British study reported that medical practices in a fluoridated area of the UK (West Midlands vs. those in a nonfluoridated area, Greater Manchester) were twice as likely to report a high prevalence of hypothyroidism in their patients! Furthermore, analysis of different parts of the UK found that the rates of hypothyroidism were statistically matched to the rates of fluoride in the local water supply!

Medications and other sources of fluoride

Izabella also lists some of the most commonly used medications that contain fluoride in this blog post: Fluoride And Your Thyroid

  • Prozac®, Lexapro®, Celexa®, Paxil®: used for depression, anxiety, or OCD
  • Prevacid®: used for acid reflux
  • Diflucan®: an antifungal used for yeast infections.
  • Fluoroquinolone antibiotics (Cipro®, Levaquin®, Avelox®): used for UTIs and other infections
  • Celebrex®: used for pain
  • Lipitor®, Zetia®: used to lower cholesterol

Other common sources of fluoride are fluoridated toothpastes and dental preparations, processed beverages and foods, pesticides, tea, mechanically deboned meat, Teflon pans and exposure in the workplace. You can read more about these sources from The Fluoride Action Network (FAN), an organization that seeks to broaden awareness about the toxicity of fluoride compounds among citizens, scientists, and policymakers alike.

The GABA and taurine hypothyroid-fluoride research is too new to have made it into Izabella’s book but since anxiety is a common symptom in hypothyroidism and Hashimoto’s thyroiditis, and based on this research, using either GABA or taurine shows promise for helping both the thyroid to heal after fluoride exposure (via water, medications, diet or workplace exposure) AND to help reduce the physical anxiety symptoms.

It seems to be a two-way street because we’ve always known that the amino acids will be effective for addressing low GABA and low serotonin levels ONLY when thyroid health is optimal (and not many people are aware of this).

I also can’t help but wonder if a small amount of GABA (or taurine) wouldn’t be helpful after known exposure to fluoride sources and certainly while you are working to reduce fluoride exposure – even if hypothyroidism is not a problem. I look forward to future research in this area.

If you’d like an overview of how I use GABA and the other amino acids with my clients you can read all about it here.

I’d love to hear if you have observed an improvement in thyroid health since using GABA for your anxiety? And how dedicated you are to avoid fluoride?

Anxiety, depression, GABA and cortisol: effects of Lactobacillus ingestion

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We now know that good bacteria or probiotics have the potential to alter brain chemistry and have an impact on anxiety and depression. You may recall my interview with Professor Ted Dinan on a prior Anxiety Summit – Microbes in the gut and psychobiotics as a potential treatment for anxiety and depression. He shared his paper and this definition of Psychobiotics: a novel class of psychotropic.

…we define a psychobiotic as a live organism that, when ingested in adequate amounts, produces a health benefit in patients suffering from psychiatric illness. As a class of probiotic, these bacteria are capable of producing and delivering neuroactive substances such as gamma-aminobutyric acid and serotonin, which act on the brain-gut axis.

Research published by Dinan, Cryan and their teams also found benefits of Lactobacillus rhamnosus on stress, anxiety and depression type behaviors in mice. This is older research (published in 2011) but it’s the first time I’ve shared it on the blog. I talk about this paper in the upcoming Microbiome Medicine 2 Summit so I like to share study excerpts and links to the study.

The write up in Science Daily is a good one – Mind-Altering Microbes: Probiotic Bacteria May Lessen Anxiety and Depression

…mice fed with Lactobacillus rhamnosus JB-1 showed significantly fewer stress, anxiety and depression-related behaviours than those fed with just broth. Moreover, ingestion of the bacteria resulted in significantly lower levels of the stress-induced hormone, corticosterone.

The part that I find fascinating is the effects of Lactobacillus on GABA receptors in the brain (GABA is your main calming neurotransmitter):

The researchers also showed that regular feeding with the Lactobacillus strain caused changes in the expression of receptors for the neurotransmitter GABA in the mouse brain, which is the first time that it has been demonstrated that potential probiotics have a direct effect on brain chemistry in normal situations.

In this paper the authors discuss the vagus nerve and the three-way communication:

…the vagus nerve is the main relay between the microbiome (bacteria in the gut) and the brain. This three way communication system is known as the microbiome-gut-brain axis and these findings highlight the important role of bacteria in the communication between the gut and the brain, and suggest that certain probiotic organisms may prove to be useful adjunct therapies in stress-related psychiatric disorders.

What is even more fascinating is this:

the neurochemical and behavioral effects were not found in vagotomized mice

What does this mean? When the researchers severed the vagus nerve in the test mice – removing the communication between the gut and the brain – they found that the behaviors and stress hormone levels reverted back to the way they had been i.e. the vagotomized mice were more anxious, more stressed, more depressed and had higher corticosterone levels.

You can find the abstract of the paper here: Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.

What does this mean for you? It means that good bacteria in your diet could well improve your anxiety and depression symptoms and even have an impact on your adrenals and cortisol levels. This could be in the form of a good probiotic and should always include fermented foods like sauerkraut, kimchi, kombucha, yogurt and kefir (if dairy is tolerated), water kefir (if dairy is not tolerated).

Have you observed an improvement in your anxiety and stress levels since adding a probiotic or fermented foods into your diet?

GABA for children: ADHD, focus issues, irritability, anxiety and tantrums

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Is GABA safe for children with symptoms of ADHD? I was asked this question after my interview on anxiety on the Diabetes Summit. I shared the question and my answer on facebook:

I’ve used GABA (and theanine) very successfully with children with physical anxiety symptoms and ADHD. I’ve also used tyrosine for the attention/focus issues. Plus I always consider gluten, blood sugar control (animal protein at breakfast often makes the biggest difference), colors/additives, low iron, low zinc and candida (this list is not inclusive but is a good starting point)

Jenny is a mom in my facebook community and responded to the above post, sharing that a friend of hers recommended GABA for her daughter after reading some of my posts. She shared this wonderful feedback:

My daughter hasn’t been diagnosed with ADHD but has a lot of ADHD qualities. We were having a huge amount of behavior problems as she is getting older (she’s 11). I did some research and went to the health food store and bought a bottle. At this point I was mentally exhausted from all the fighting and drama at home and at school. I was desperate and didn’t want to put her on any hard medication.

She has had amazing behavior at school and at home since giving it to her. She’s almost like different child. GABA has truly changed our life. She’s been taking it for almost 2 months.

What wonderful results! I’m thrilled for Jenny and her daughter. I asked Jenny to share what her daughter’s symptoms/behaviors were before they used the GABA and which symptoms improved. This is what Jenny shared:

…before the GABA she was irritable, she was fighting with her teacher and schoolmates, she couldn’t focus and was distracted by anything and everything, she was constantly disrupting the class and she was throwing major tantrums over ridiculous stuff (like her hair didn’t do what she wanted), she was mouthy and everything was a fight.

We are not seeing 99% those behaviors at all anymore. She of course is still your typical pre-teen but if I say “no you can’t have that” our “no you can’t go there” her reaction is OK. Before it would have been a major fight or meltdown. Her teacher is reporting to me every day about her wonderful days.

I love hearing this feedback and it’s not unusual for children to act out when they have low GABA levels. Adults may identify with being anxious, but children may appear irritable, unfocused and distracted, may have tantrums and meltdowns, and all the while not be able to articulate how they are feeling.

Long–term use of GABA and root causes of low GABA

Jenny also posed some additional questions about GABA:

I do have some questions – I can’t really find anything online saying that it’s OK to give to kids. I mean, I’ve seen the results but it still worries me. She takes one 25 mg pill a day – do you think that’s OK?? Should I give her more or less or keep it the same? Just wondering your opinion?

I shared some of this feedback on the facebook thread and have elaborated on it here on the blog.

There is no research on children and the long-term use of amino acids but plenty of clinical evidence showing they can be used safely for 3-12 months. But I am also always working with my clients to find out why there is the deficiency in the first place and addressing that. This could include any or all of the following:

  • low zinc/vitamin B6/low iron which are all co-factors needed to make GABA (and then I’d want to know why are these low)
  • dysbiosis, parasites and/or candida (we make GABA in the gut and we may have GABA-eating bacteria in the gut – such as gabavorous)
  • too much stress at school, playing sports and/or at home
  • not getting enough sleep
  • not eating animal protein at breakfast (this affects blood sugar control and can stress the adrenals and impact cortisol, sex hormones and brain chemicals)
  • gluten sensitivity (gluteomorphins in gluten can impact mood and gluten can damage the gut leading to nutritional deficiencies)
  • low animal protein intake and/or eating a low-fat diet
  • low stomach acid (so you can’t digest the protein you’re eating)
  • toxin exposure (like pesticides or BPA)
  • low total cholesterol (caused in part by low levels of enzymes for fat digestion or a low-fat diet)

I shared these 60+ Nutritional and Biochemical Causes of Anxiety on my closing call of the The Anxiety Summit season 3.   I use this to help put the puzzle pieces together for my clients to resolve their anxiety and related issues like ADHD, insomnia, sadness, irritability etc.

When Jenny saw some of the root causes for low GABA she shared that she’s going to be making an appointment with her doctor. Keep in mind that in this instance it will need to be a functional medicine doctor or nutritionally trained doctor or a doctor who is open to learning about all this. I always also suggest taking a copy of my book The Antianxiety Food Solution to share with the doctor too!

What GABA product?

I typically have clients start with Source Naturals GABA Calm which contains 125mg of GABA. I was curious to know which 25mg GABA product she was using. It turns out to be a sublingual product by KAL.

  

 

You can find the other GABA products I use and recommend here and the precautions with using GABA here. Typically it’s an amino acid that the least issues, unless too high an amount is used.   I often hear that 500mg or 1000mg was used and caused dizziness or breathlessness – these are clues it’s too much!

I asked Jenny if I could share here to give other mom’s hope and inspiration and practical results so they can help their children – and really I appreciate her being willing to do so.

Thanks for sharing Jenny! Happy mama and happy daughter – it warms my heart to hear stories like this!

Have you used GABA and observed a reduction or elimination of ADHD, irritability or anxiety?

If you’re a practitioner, have you seen results like this with your clients or patients?

Anxiety: when to use GABA and tryptophan and how much to use

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When you have anxiety it can be confusing trying to figure out the root cause. I like to start by assessing for low GABA and low serotonin because when you address these with targeted individual amino acids you typically see results right away and feel hopeful (and now have time to look for other root causes like gluten issues, high cortisol, gut issues, dietary changes etc).

But there may still be some confusion about when to use GABA and when to use tryptophan and how much of each of these amino acids to use.

I’d like to share a question I received on this blog: I am on 5-HTP for anxiety and I am wondering about trying tryptophan instead and my response so you have a clearer understanding of this:

I have started with Source Naturals GABA Calm 125 mg, 2 on awakening and two in mid-afternoon, and 2 GABA Relaxer at bedtime. It has taken some anxiety edge away from me, but I still feel some anxiety on and off, not so severe as before. I used to feel very anxious on awakening. I want to improve more.

Today, I ordered Lidtke L-trytophan 500mg and am expecting to receive it in a week. I plan to take 2 Gaba Calm on awakening and 2 in mid-afternoon, then add one 500mg Trytophan mid-afternoon and one 500 mg trytophan at bed time.

Is this a good plan? Or shall I have 2 GABA Calm on awakening, 2 trytophan mid-afternoon and 2 trytophan at bedtime.

It’s an excellent question and this is my feedback (with some additional information here for this blog post)

Firstly I’m so pleased to hear the GABA products has taken some of the anxiety edge away.

I would expect this when someone has the low GABA type of anxiety and hear this all the time despite the fact I continue to be asked the blood brain barrier question and does GABA really work as a supplement.

There is also no specific formula to be followed because each person is different and when I’m working with someone we’re figuring out what is working and why and adjusting accordingly. If something is working we continue with that until no additional benefits are seen.

Ask yourself what low GABA anxiety symptoms (this is the physical anxiety) have improved with the GABA and how much (rate each one before – out of 10; and what are they now – out of 10).

From your question it sounds like they could improve more – so if we were working together I’d continue to increase GABA before adding something new. I’d do this until the low GABA symptoms are resolved or until no additional benefits are observed.

Remember when it comes to brain chemical imbalances and anxiety we have 3 anxiety types

  1. Low GABA anxiety type (physical anxiety, more stiff and tense muscles)
  2. Low serotonin anxiety type (mental anxiety, ruminations, negative self-talk, worry)
  3. Low blood sugar anxiety type (physical anxiety, but more shaky)

You need to figure out which type of anxiety you are experiencing and address that. It can be different for each person but it’s not uncommon to experience all of the above.

Once that has been done and we have the ideal amount of GABA and no more low GABA anxiety symptoms I’d then check what low serotonin symptoms my client has (these are the busy mind, ruminations type or worry anxiety).

If she does have some of these symptoms, we pick one or two symptoms and do a trial with 1 x 500mg tryptophan opened on to the tongue (or less if she’s super sensitive). She rates the symptoms out of 10 before the tryptophan trial and then after the trial. Depending on how she responds on the trial, we’ll decide if she needs 1 or 2 x 500mg mid-afternoon and evening. The bedtime dose also depends on how bad the insomnia is. We continue to increase as needed based on symptoms until she has no more low serotonin type symptoms or until no additional benefits are observed.

All the while we are starting to make other changes – like diet, eating for blood sugar balance (this and using glutamine helps with the low blood sugar anxiety type), no caffeine, no sugar, looking for high cortisol, no gluten, looking at gut health and for other nutritional deficiencies.

Here are some links to additional resources related to the above:

I’d love to hear your feedback – do you/did you have the low GABA type of anxiety or the low serotonin type of anxiety or the low blood sugar type of anxiety or all three?

And feel free to share the before rating (from 1 to 10) and the after rating (from 1 to 10) once you’re taking the corresponding amino acid.