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Archives for May 2018

Brain and mood benefits of a ketogenic lifestyle

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Keto Edge Summit

We know that ketones help you burn fat for energy, powerfully reduce inflammation and show promise in preventing and eradicating diabetes, cancer, autoimmune and neurodegenerative diseases like Alzheimer’s and Parkinson’s, and even play a role in mental health conditions like anxiety and depression. Experts on the Keto Edge Summit share many of the brain and mood benefits of a ketogenic lifestyle.

Dr. David Jockers shares this about anxiety and GABA and glutamate (his #5 benefit) in his interview on the ‘Top 7 Benefits of a Ketogenic Lifestyle’:

We have an epidemic of depression and anxiety in our society. And so, one of the key things that being keto-adapted does—not only does it downregulate inflammation in the brain, and we know that depression now is really neuroinflammation.

So the other big thing is we’ve got these neurotransmitters. One is glutamate; the other is GABA. Glutamate is an excitatory neurotransmitter, meaning that it helps us think sharply and quickly. What balances glutamate is this other neurotransmitter called GABA, gamma-aminobutyric acid. And it’s inhibitory. It helps balance us and calm us. What we find is that people with anxiety, they have high glutamate, low GABA. They don’t have a good ratio. Same thing with depression.

So what a ketogenic diet does, when we’re keto-adapted, it helps balance out the glutamate to GABA ratio and creates stability there. What does that mean to you? That means you’re going to be able to think sharply and quickly but you’re not going to get out of control. Your brain’s not going to be going too fast. You’re not going to be at risk for anxiety, for depression in the same way. You’re going to notice just an improved mood, more emotional balance.

Dr. David Perlmutter shares the importance of blood sugar regulation in his interview ‘Keto for Brain Health’:

Blood sugar regulation is pivotal as it relates to the destiny of your brain. Probably the most important biometric that determines whether you will or won’t become an Alzheimer’s patient is what your fasting blood sugar is today.

Even with the ApoE-4 gene, the ketogenic diet, physical exercise, and gluten-free, lowering sugar and carbs… are important changes that can absolutely rewrite your book.

I think it’s important to understand that humans have probably been in a state of ketosis most of the time over most of our existence on this planet. It’s only been in the last 10,000 years or so when we’ve created agriculture that we’ve had this robust availability of carbohydrate resources that has really shifted the human diet to one that is carbohydrate-based as opposed to fat-based.

Dr. Cheryl Burdette also covers inflammation in her interview, ‘Inflammation and the Ketogenic Diet’:

So when we see markers of oxidative stress high, not only do we know the DNA is suffering but we know our mitochondria, our powerhouse is suffering and, therefore, our brain is suffering. And so what you see is a high 8-OHdG – you see that high in conditions like Alzheimer’s or Parkinson’s but you even see it high in depression or bipolar or anxiety. What you also see is a ketogenic diet, helps to lower that. What you also see is adding more antioxidants, helps to lower that. So again, we’re back to our green leafies with our good fats.

The Keto Edge Summit is available online and there are REPLAYS ALL WEEKEND. You can still register here to hear the replays

Please share your gems and what you’ve implemented or are planning to implement in terms of a ketogenic lifestyle.

Thyroid health and anxiety: fluoride, mercury, nitrates, phthalates and other toxins

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thyroid health and anxiety

Dr. Amy Myers MD, author of The Autoimmune Solution, The Thyroid Solution and The Autoimmune Solution Cookbook, presented on thyroid health at the recent Bioceuticals Conference on Autoimmunity in Melbourne. I promised to share some highlights from her presentations (she did 4 different ones) and since toxins play such a huge role when it comes to anxiety, I’m sharing some highlights from the toxins presentation and the top thyroid toxins you need to avoid: mercury, perchlorate, halides or halogens, nitrates, plastics and parabens and phthalates. These toxins all also play a role in anxiety too.

We also have a new meta-analysis published earlier this month: Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis – A Systematic Review and Meta-analysis confirming what functional medicine practitioners like Dr. Amy Myers, Dr. Mark Hyman and Dr. Izabella Wentz have been educating about for years:

Patients with AIT [autoimmune thyroiditis] exhibit an increased chance of developing symptoms of depression and anxiety or of receiving a diagnosis of depression and anxiety disorders.

Taming the toxins is one of 4 pillars that Dr. Myers covers in her approach for preventing and reversing autoimmune disease:

Pillar I: Heal your gut.

Pillar II: Get rid of gluten, grains, and legumes.

Pillar III: Tame the toxins.

Pillar IV: Heal your infections and relieve your stress.

Dr. Myers shared the top thyroid toxins you need to avoid:

  1. Mercury
  2. Perchlorate
  3. Halides or halogens
  4. Nitrates
  5. Plastics
  6. Parabens and phthalates

“A 2011 study found that women with high mercury exposure are 2x more likely to have positive thyroid antibodies.” The paper: Mercury and thyroid autoantibodies in U.S. women, NHANES 2007-2008, reports this increase for thyroglobulin autoantibodies.

As far as anxiety is concerned, Kris Homme shares much evidence to support her belief that mercury toxicity is a likely root cause of the other root causes of anxiety in our Anxiety Summit interview.

Halogens or halides also have an impact on thyroid health. In areas where fluoride is added to the water there are “2x the rates of hypothyroidism than non-fluoride areas.”

Bromine is also an issue and is found in “flame retardants, plastics, many baked goods and citrus flavored drinks.”

GABA in relation to thyroid health and fluoride was not covered in the presentation but there is research showing that GABA reversed fluoride-induced hypothyroidism in an animal study. I blogged about this research here: GABA protects against hypothyroidism caused by fluoride and reduces anxiety. The fluoride-exposed mice that were subsequently treated with GABA were found to have improved results for T4, T3 and thyroid hormone-binding globulin (TBG levels) and healing of the structural abnormalities in thyroid follicles that were observed after fluoride exposure.

The authors conclude with this statement, reporting that GABA acted as a natural antioxidant:

To the best of our knowledge, this is the first study to establish the therapeutic efficacy of GABA as a natural antioxidant in inducing thyroprotection against fluoride-induced toxicity.

The amino acid GABA  helps with physical-tension and stiff-and-tense-muscles type of anxiety, often in certain settings like public speaking or driving, and the need to self-medicate to calm down, often with alcohol but sometimes with carbs and sugary foods. Insomnia can also be due to low GABA and you’ll experience physical tension (rather than the ruminating thoughts which is the low serotonin type of insomnia – although it’s not uncommon to experience both). GABA also helps ease panic attacks, muscle spasms and pain relief when muscles are tight.

“Nitrates, found in fertilizer and foods, resemble iodine enough to block thyroid hormone absorption.” In one study, Nitrate intake and the risk of thyroid cancer and thyroid disease women were found to be “more likely to develop thyroid cancer with higher nitrate levels in the water.” Research shows similar results with nitrites and children and thyroid cancer.

Since the amino acid taurine offers neuroprotection against ammonia in the central nervous system I suspect GABA may offer some protection against nitrates too.

Parabens and phthalates found in many personal care products (and fast-foods) “mimic estrogen and disrupt the hormonal cascade”, with higher estrogens resulting in higher TBG (thyroxine binding globulin).

“A CDC study found phthalates were 39% higher in the urine of individuals who ate 35% of their calories from fast food.” This CNN article: Fast food serves up phthalates, too, study suggests covers many of the hormonal impacts

The American College of Obstetricians and Gynecologists released a report in 2013 stating that high levels of exposure to phthalates could lead to adverse reproductive outcomes in women. Research has linked these chemicals with increased risk of fibroids and endometriosis, which can cause infertility, and reduced IQ and behavioral problems in children exposed in the womb. High phthalate levels have also been linked with diabetes risk in women and adolescents.

There are countless ways that people can be exposed to phthalates. They are found in soaps, perfumes, nail polish, medications, and we can ingest, inhale and absorb them through the skin.

Out of all these routes of exposure, however, diet is emerging as a major one.

Dietary exposure is a major route of exposure of phthalates and this is one of many excellent reasons to cook and eat home-cooked meals. Dr. Myers makes it easy for you in her wonderful new book The Autoimmune Solution Cookbook.

Mycotoxins from mold are also an issue as is poor mouth health. I was pleased to see EMFs mentioned as it is a growing concern and is under-rated as having harmful effects on the thyroid and when it comes to unresolved anxiety, SIBO, oxalate issues and high cortisol.

As far as detoxification, Dr Myer’s has these general recommendations:

  1. Infrared sauna
  2. Glutathione, the master antioxidant and detoxifier
  3. Milk thistle, magnesium and alpha-lipoic acid (ALA)
  4. Cruciferous vegetables such as cauliflower, broccoli, cabbage
  5. Sulfur rich foods such as onions, garlic, eggs

In her bestselling book, The Autoimmune Solution (my Amazon link), Dr. Myer’s covers the four pillars in great detail. You can read more about taming the toxins in this blog post.

Have you identified and eliminated exposure to these toxins and seen improved thyroid health and/or reduced anxiety? Is ongoing detoxification a priority for you?

The Human Longevity Project – Secrets of the World’s Healthiest People

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The Human Longevity Project is a first-of-it’s-kind 9 part online documentary filmed over 2 years, in over 50 locations, with over 90 expert interviews!

Join Health Researcher, Jason Prall, as he travels the world investigating why certain people live extraordinarily, healthy, happy and long lives.

Here is a trailer to inspire you to watch and learn and go on this amazing journey with Jason and the people he interviews:

With this documentary he wants to share that there are

  • populations all over the world that are virtually free of chronic disease
  • places where people typically live well into their 90s and 100s
  • ways to live a healthier, longer and happier life, using strategies that work for the oldest populations… free of fad diets and short-lived health trends.
  • ways to get clear on what naturally works to cure depression, anxiety, and overwhelm
  • new and proven ways to treat and prevent most epidemic diseases
  • tools to turn your mitochondria into a powerhouse for your body, so you get more energy and stamina throughout the day

Jason not only traveled the world to learn from these healthy populations, he interviewed leading researchers, doctors and experts to uncover the underlying mechanisms that afforded them such long, healthy and happy lives.

The results are stunning and scenery is superb!

(It’s truly magnificent and I’ve only seen snippets! It takes me back to my late 20s when I backpacked through Europe and lived like the locals did, eating amazing local food, explored beautiful Greece and Turkey and met incredible people!)

What’s wonderful is that you can now learn the secrets of the world’s healthiest people, and how to apply their wisdom to your modern life.

Here are some of my favorite quotes from just a few of the amazing speakers:

Yes to having a sense of purpose – a sense of purpose is the only one thing you need! Purpose is SO important and Deanna Minich, PhD shares why on The Human Longevity Project.

Do you have a sense of purpose? And how has it helped you heal and live a fuller life?

I know that quitting my computer job over 15 years ago and going back to school to become a nutritionist was the best thing I ever did! Helping others finding nutritional solutions for their anxiety symptoms is so incredibly rewarding. It’s my purpose in life – that’s for sure! I actually consider my own anxiety and panic attacks a gift now – a gift that led me to what I do today!

I love this quote from Preston Smiles:

It’s not the happy people who are grateful, it’s the grateful people who are happy

And don’t you just love his name and lovely smile too!? So much wisdom!

And wisdom from 68-year old Cristina in Costa Rica – go barefoot and walk on the ground to raise our defenses and build immunity.

Ayako, from Japan, is 83 years old and she says this:

The most important thing is balance in your way of eating, sleeping and work. If there is an imbalance you will get sick

I hope you feel as excited about this as I do! You can register for The Human Longevity Project here

Enjoy every beautiful minute of it!

GABA, 5-HTP and melatonin isn’t working anymore for my insomnia and tryptophan gives me a migraine – what should I do?

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Today I’m addressing a great question I received on a recent tryptophan blog about insomnia and the use of the amino acids GABA and 5-HTP in a combination product together with melatonin, and what the next steps should be when you are not getting the expected results. And if continuing with tryptophan is a good idea when it seems to be causing a migraine and isn’t leading to a whole night’s sleep. Here is the question:

I have suffered from insomnia for most of my life. I just got your book and am loving it! Thank you for all that you do. My symptoms seem to be high for both low GABA and low serotonin [here is the questionnaire].

I also believe I have a blood sugar problem, so I’m starting to follow your suggestions for that.

I’ve been taking a supplement for sleep that has both GABA and 5-HTP in it, along with melatonin. It worked for a year, however it just recently stopped working.

I thought maybe I should try tryptophan. After taking only 220 mg per night, along with 5 mg of melatonin, I was able to sleep, but not through the entire night. However, the next day I woke up with a horrible headache/migraine. I know it was the tryptophan because I did a trial and tried a night without it and then again with it and the nights I took it, sure enough, the migraine would return.

I must add that I had bloodwork done and tested low for melatonin, which is why I was adding the melatonin into my protocol.

My question is: do I continue with a higher dose of GABA, 5-HTP and melatonin, since it worked for a year i.e. do I up the dosage of the supplement I’ve been taking? Or do I continue trying different doses of tryptophan?

I shared this response in my comment (with some additions for this blog post).

Always first address the nutritional foundational aspects

Firstly, I was glad to hear she is loving my book The Antianxiety Food Solution (my Amazon link) and implementing dietary changes. This is so foundational to any protocol for both anxiety and insomnia. Too often, someone hears me talking about the amazing amino acids and forgets the nutritional basics of real whole food, quality animal protein (like wild fish, pastured eggs and chicken, grass-fed red meat), organic veggies and fruit, healthy fats (like olive oil, coconut oil and butter), fermented foods and broths, and no gluten, caffeine or sugar.

I don’t ever have clients push through

With regards to her trial of tryptophan I shared that I don’t ever have clients push through on a product that is causing any adverse effects, and especially when it’s a migraine. She was smart and trialed the tryptophan twice to make sure it was the tryptophan that caused the migraine and not something else.

Capitalize on what has worked and increase one at a time

With regards to the GABA, 5-HTP and melatonin I shared that I always like to capitalize on what has worked in the past (or is currently working) and would rather increase the 5-HTP and/or melatonin and/or GABA one at a time.

Notice that I said increase these products one at a time. She is taking a combination product so it’s impossible for her to do this. Maybe her GABA levels are now good (because her progesterone levels have improved due to be on a regular zinc supplement or because she has been doing regular yoga sessions) and maybe she needs more serotonin support (because her estrogen levels are off because of recent exposure to xenoestrogens in plastics).

Even though is research showing that a combination product containing GABA and 5-HTP improved sleep and sleep duration more than the use of either of the two amino acids alone, based on her feedback, if we were working together I would have her do each of the GABA, 5-HTP and melatonin separately. This way it’s easy to mix and match and increase one and possibly lower the other, until the ideal combination is found for her unique needs at this time in her life.

She may even find she only needs GABA or only needs 5-HTP or only melatonin. She may also find she needs sublingual melatonin for helping her fall asleep and timed-release melatonin for helping her stay asleep.

She mentions the amino acid questionnaire so it sounds like she is clear on her symptoms: low GABA physical anxiety affecting her sleep and low serotonin mental worry-type of anxiety affecting her sleep. So as she trials the individual amino acids she can see how she does symptom-wise in order to find the ideal amount.

Other factors to consider with insomnia

It’s often straight-forward with the amino acids and the great thing is that one you have the correct combination you will see results in a few days to a few weeks. But There are other factors we may need to consider with insomnia:

  • Keep in mind that 5-HTP can raise cortisol and low blood sugar can indicate adrenal issues so looking at high cortisol as a factor in the sleep problems would be something to consider. A 4-collection saliva test will measure this and my favorite product for lowering high cortisol is Seriphos. Other nutrients for adrenal support may be needed too.
  • Just addressing low blood sugar can often improve insomnia. Eating to support blood sugar swings, early morning sunlight and no blue light after dark can make a world of difference.
  • Other sleep factors we always want to consider: sex hormone imbalances, parasites (they are more active at night and can keep you awake and play a role in high cortisol), accidental gluten exposure, SIBO (small intestinal bacterial overgrowth), candida, sleep apnea and mouth breathing, EMFs (WiFi in the home, commuting with the iphone on, a new cordless phone etc.) and medication side-effects (benzodiazepines are a common one).

I really appreciate questions like this being posted on the blog so others like you also get to benefit. This question also demonstrates just how our needs for certain nutrients can change over time and how we may to keep adjusting what we are doing.

In case you have questions about specific products that I use with clients, here is my supplements blog and more information on GABA for the physical type of anxiety and 5-HTP/tryptophan for the worry-type of anxiety.

Can you relate to this scenario? Feel free to ask your questions about sleep, GABA, 5-HTP, tryptophan and melatonin and share your experiences with these products and how they have helped you or if you’ve had issues with any of them.

The Autoimmune Solution Cookbook by Amy Myers MD

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There is a wonderful new recipe book out this week and I want you to know about it!

Dealing with an autoimmune or other chronic health condition such as Hashimoto’s, IBS, Celiac, RA, Psoriasis, chronic fatigue or fibromyalgia, or even just committing to your family’s health does NOT have to mean giving up delicious foods!

No one knows this better than my dear friend and world-renowned functional medicine physician, Amy Myers, MD.

Amy Myers reversed her own autoimmune condition by addressing the root causes of her illness and diet played a HUGE role. She continues to follow the same dietary program that she recommends to her patients and community.

We actually ate out together in Melbourne at the recent Bioceuticals Symposium and I saw her put The Myers Way® (her proven program) of eating into practice at the restaurant, making sure everything she was eating was safe and would not trigger an autoimmune flare. Our server worked hard making sure all her questions were addressed in a satisfactory manner and she set a great example for all of us.

She does this in her wonderful new cookbook, setting a great example and guiding you to make the right choices in order to reduce inflammation, heal your leaky gut and help you move toward the optimal health side of the autoimmune spectrum and stay there.

Here I am with integrative pediatrician Elisa Song MD and functional medicine physician, Amy Myers, MD.

Amy inspires you to cook delicious meals at the same time. She helps you change the way you look at food, both when you’re cooking at home for our families, and when we’re eating out and traveling.

This new book, The Autoimmune Solution Cookbook (my Amazon link), contains over 150 absolutely delicious, easy-to-make, autoimmune-reversing recipes. Amy shares this:

Whether you’re a five-star chef or just getting started in the kitchen, I created these recipes to be a piece of cake (YES! There’s even a birthday cake recipe I created for my daughter).

This cookbook is perfect for you if you:

  • Have an autoimmune or other chronic condition
  • Know that autoimmunity runs in your family
  • Currently follow an autoimmune, Paleo or ketogenic diet
  • Have read The Autoimmune Solution and have already followed its thirty-day protocol, this cookbook is the perfect companion for spicing up your diet and adding more variety to your mealtimes
  • Are dealing with leaky gut, seasonal allergies, asthma, or eczema
  • Have Hashimoto’s, Graves’, or any other type of thyroid issue
  • Deal with digestive issues such as bloating, gas, constipation, and more
  • Have food allergies or food sensitivities
  • Have a loved one dealing with any of the above issues and are looking for the perfect gift for them
  • Are looking for a gift for your doctor or other health practitioner

Here are 2 yummy recipes to get you tempted, your mouth watering and cooking: Refreshing Mango-Avocado Salsa and Coconut Shrimp.

Refreshing Mango-Avocado Salsa

With summer approaching, this refreshing mango-avocado salsa makes the perfect poolside snack or cookout appetizer served with plantain chips. Or add it to grilled fish, shrimp, or chicken for an extra boost of inflammation-fighting Omega 3 fatty acids. Makes 2 cups

Ingredients:

1 mango, cubed
1 avocado, cubed
½ red onion, finely chopped
3 tablespoons chopped fresh cilantro
Juice of 1 small lime
1 tablespoon extra virgin olive oil
¼ teaspoon fine sea salt
½ teaspoon freshly ground black pepper
½ teaspoon ground cumin

Instructions:

In a bowl, combine all ingredients and mix gently. Serve immediately

 

Coconut Shrimp

When I was growing up in New Orleans, my grandparents took the family out to dinner at the Yacht Club for special occasions, and I always ordered a fried shrimp po’ boy—a traditional Louisiana sandwich. This substitute for fried shrimp is a healthier option that everyone will love. The shrimp are tossed with coconut flour and shredded coconut instead of breadcrumbs— and they are so easy to make! My husband and I served this as an appetizer at our wedding and they were a huge hit! Serves 4

Ingredients:

2 tablespoons coconut flour
½ cup unsweetened shredded coconut
1 teaspoon garlic powder
1 teaspoon onion powder
½ teaspoon fine sea salt
½ teaspoon ground black pepper
¾ cup full-fat coconut milk
1 ½ tablespoons coconut aminos
1 pound wild-caught shrimp

Instructions:

  1. Heat oven to 400°F. In a shallow bowl, whisk together coconut flour, shredded coconut, garlic and onion powders, salt, and pepper.
  2. In another shallow bowl, whisk together the coconut milk and coconut aminos.
  3. Dip each shrimp into the liquid mixture, and then into the dry mixture to coat. Arrange in a single layer in a baking dish. Bake for 15 to 20 minutes, until golden brown. For extra crispiness, remove the pan and set the oven to broil. Broil the shrimp for 4 to 5 minutes.

Some of the other recipes I’m really looking forward to trying are the creamy zucchini-basil soup, the herbed roast chicken, the world’s best Asian flank steak, the rosemary sea-salt crackers (made with cassava flour), the spinach artichoke dip (I’ll replace the spinach with low-oxalate dino kale), raspberry cheesecake bites (I’ll make it with blueberries instead of high-oxalate raspberries), and the apple crisp.  There are so many delicious recipes!

There is no perfect eating plan for everyone and Amy has created this eating plan and recipes to cater for the majority of those with an autoimmune condition. I really appreciate that recipes are marked as being autoimmune-friendly, thyroid-friendly, suitable for candida and SIBO, and low histamine.  However, if you do have oxalate issues you will need to adjust some of the recipes. Also, if you have issues with collagen making your anxiety or insomnia worse then I recommend adding some protein powder to the recipes that call for gelatin or collagen, and/or consider a trial of tryptophan.

Here’s the official book blurb:

The companion cookbook to the revolutionary New York Times bestseller The Autoimmune Solution, filled with more than 150 nutritious, easy-to-prepare, every day recipes to heal symptoms of inflammation and autoimmune disorders, including Graves’ Disease, Psoriasis, Fibromyalgia, Lupus, Celiac disease, Hashimoto’s thyroiditis, and Multiple sclerosis.

Nine in ten Americans suffer from inflammation or an autoimmune disorder—conditions for which conventional medicine has no cure. Minor irritations like rashes and runny noses are ignored, while chronic and debilitating diseases like Crohn’s and rheumatoid arthritis are handled with a cocktail of toxic treatments that fail to address their root cause. But as Dr. Amy Myers revealed in The Autoimmune Solution, there are solutions. In this invaluable cookbook, she now shows you how to repair your body and reverse your symptoms by eating your way to good health.

The Autoimmune Solution Cookbook delivers more than 150 grain-free recipes designed to prevent and reverse the full spectrum of autoimmune diseases, including allergies, obesity, asthma, cardiovascular disease, fibromyalgia, lupus, IBS, chronic headaches, fatigue, multiple sclerosis, colitis, Graves’ disease, and Hashimoto’s thyroiditis. As our food and environment becomes more toxic, the health of millions of us have been impaired. Thanks to Dr. Myers, you no longer need to rely on prescriptions—with troubling, sometimes dangerous side effects—to counteract your body’s over-reactive immune system. The Autoimmune Solution Cookbook is the healthy alternative to cope with and conquer inflammatory-related symptoms and diseases.

If you’re ready to enjoy amazing meals that will help you take back your health and your life, this book is an absolute must-have, so get your copy of The Autoimmune Solution Cookbook today – on Amazon here (my affiliate link) or from your favorite book store.

This cookbook is the perfect companion to The Autoimmune Solution (my affiliate link), a wonderful book that introduced The Myers Way®, empowering so many to reverse their autoimmune conditions.

Learn more about the book and claim the book launch gifts here.

And stay tuned for an email notification from Dr. Myers about the upcoming Autoimmune Program webinar being held online on May 17. She’ll be sharing more about her group program if you’re the kind of person looking for a community-based program.

Happy cooking and do let us know how you enjoy the recipes!

If you have questions or feedback please post them in the comments below.

KetoNutrition: From Science to Emerging Applications and Practical Implementation

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I had the pleasure of hearing Dominic D’Agostino, NASA crew member, researcher and Associate Professor at the University of South Florida present on “KetoNutrition: From Science to Emerging Applications and Practical Implementation” at the 6th BioCeuticals Research Symposium in Melbourne last weekend. His presentation was based on decades of evidence that supports the anticonvulsant and neuroprotective properties of nutritional ketosis. It was one of my favorite presentations and I’m thrilled to share some of the highlights with you here.

Ketones are alternative fuels and neuroprotective signaling metabolites – increasing longevity, lowering inflammation, dampening oxidative stress, lowering glutamate and raising GABA.

In this slide he shared how the proven applications of nutritional ketosis are extensive – including epilepsy, type 2 diabetes, weight loss, NAFLD, mitochondrial disease and inflammation, GLUTID Syndrome, PDH Deficiency, Lennox-Gastaut Syndrome, Dravet Syndrome and Rett Syndrome.

There is emerging evidence for acne, PCOS, exercise performance, wound healing, longevity, cancer, CNS Oxygen Toxicity, autism, Angelman’s Syndrome, ALS, MS, Neuropathies, Alzheimer’s disease, brain injury, neurodegeneration, anxiety, depression, bipolar and schizoaffective disorder.

Seizures, cancer and the ketogenic diet

 

In his TEDx talk from 2013 Dr. D’Agostino shares the benefits of a ketogenic diet for seizures and how while studying the effects of gasses on the brains of Navy Seal divers, he developed an approach for metabolically starving cancer cells through diet and compressed oxygen, replacing chemotherapy, surgery, or radiation.

He ends by saying this:

Future treatments and prevention of many diseases may fall back on the ancient wisdom of Hippocrates when he said “let food be thy medicine”

As you can see from the applications slide above, much more research has been done on the therapeutic benefits of a ketogenic diet since this 2013 TEDx talk.  And food truly is medicine!

In one of his studies, the first paper above, ketone supplementation was found to have an anti-anxiety effect – Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats:

We conclude that ketone supplementation may represent a promising anxiolytic strategy through a novel means of inducing nutritional ketosis.

Adenosine and the adenosinergic mechanism

He shared a number of studies that describe how the anti-anxiety and anti-convulsant effects of ketone supplementation are mediated, in part, through the adenosinergic mechanism. This was one of his papers – Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats.

Adenosine is a neurochemical which many coffee-drinkers may be familiar with since: “Caffeine increases wakefulness [and often anxiety] by antagonizing adenosine receptors, and adenosine itself promotes sleepiness” and a feeling of calm.

Older research finds that there is the “involvement of adenosinergic receptor system in anxiety related behaviours.” More recent research describes adenosine as “a mediator with multisystemic effects”, and it is produced by almost all cells, playing a role in heart function, sleep, bone health, activation of the immune system and mediating the effect of various hormones. I expect we’ll be hearing a great deal more about adenosine in relation to ketogenic diets in the near future.

The microbiomes of astronauts sync up and so do their serotonin levels

This was one of my favorite presentations at the BioCeuticals Symposium and it was really great to meet Dominic afterwards and learn more about future anxiety research. He shared that his lab has planned research on the benefits of ketosis for both anxiety and improved cognitive function.

It was also fascinating learning from someone who has been in space and hearing how the microbiomes of the astronauts sync up when they are all in space together. And so do their serotonin levels.

If the ketogenic diet is new for you or you want to see the latest research, check out Dominic’s work at Keto Nutrition. And if you want to learn more from Dominic and other keto experts, the Keto Edge Summit runs all of next week.

I also write about two schizoaffective case studies here and share questions and concerns I have about the ketogenic diet. It’s not a panacea for everyone in all instances. But the therapeutic benefits are profound when someone needs to adopt this dietary approach.

Feel free to ask questions and share you experiences with a ketogenic diet – in the comments below.