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Nutritional testing for figuring out the root cause/s of your anxiety

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test

This blog covers the nutritional or functional testing I use with my clients, and what tests I’d run (and/or have my client’s doctor run) if everyone had unlimited funds.

Often it can be challenging to figure out the root cause/s of your anxiety, but that’s where questionnaires, nutritional/ functional/ testing, and a good practitioner (or team of practitioners like nutritionist, functional medicine doctor, nurse practitioner, therapist etc.) comes in – so you can put all the puzzle pieces together.

The following are what I have most of my clients do:

  • The basic blood work that I like to see is a lipid panel, a CBC (complete blood count), a metabolic panel, an iron panel that includes ferritin, and a thyroid panel that includes TSH, free T3, free T4, reverse T3, thyroid antibodies (antithyroglobulin and antithyroperoxidase), vitamin D, and CRP (C-Reactive Protein). There is much we can determine by looking at functional values: digestive status, possible gut dysbiosis, adrenal function, malabsorption, inflammation, as well as low iron, low vitamin D etc. I’ll share more about the markers on this panel of tests in a later blog post.  
  • I also like to see an adrenal saliva test, which measures four times cortisol. So it’d be a saliva collection first thing in the morning, noontime, 5:00 PM, and 10:00 PM. It also shows DHEA; Secretory IgA; and an anti-gliadin antibody (a marker of gluten sensitivity)
  • I rely on the Pyroluria Questionnaire and response to the supplements. The pyroluria urine test is a possibility. But I seldom have clients do it, because we can often see a false negative.
  • For neurotransmitter imbalances – low serotonin, low GABA, low catecholamines and low endorphins – I rely on the Amino Acid Questionnaire and response to amino acids. Vitamin Diagnostics offer a platelet serotonin/dopamine/norepinephrine and epinephrine panel, which is the most accurate way to measure neurotransmitters, if you really wanted to measure them. I don’t ever recommend urinary neurotransmitter testing. It just doesn’t seem to correlate with symptoms.
  • B12 levels. To determine a B12 deficiency, you would want to measure B12, methylmalonic acid (or MMA), and homocysteine.
  • The 23andme genetic testing. This will measure MTHFR, COMT, MAOA, CBS, GAD and many more polymorphisms.

Here is other testing that may be helpful for certain individuals:

  • A sex hormone saliva test. This will measures progesterone, estriol, estrone, estradiol, and testosterone.   I have a wonderful nurse practitioner that I work with, and, if need be, will refer people out to the nurse practitioner if we need support when it comes to bioidentical hormones.
  • A food intolerance test that measures IgG antibodies to 60+ foods. This shows a delayed reaction to the foods.
  • A fatty acid test. This will measure omega-3s (EPA and DHA), omega-6s and omega-9s. And it’ll also measure trans fats. Doing this test is really helpful if you have pyroluria or think that you may have pyroluria.
  • A RBC (red blood cell) magnesium test. Dr. Carolyn Dean talked about the usefulness of this test season 2 of The Anxiety Summit: Take magnesium and melt your anxiety away
  • A stool test. Metametrix/Genova and Diagnostechs offers functional stool testing. It’ll show good bacteria, yeast, parasites, bad bacteria, and digestive markers.
  • A hydrogen breath test or SIBO test. Genova offers this or you can ask your conventional doctor to order this.
  • The H/pylori antigen test. Genova offers this or a conventional doctor can do this.
  • Intestinal permeability profile. Genova offers this.
  • A celiac panel. Genova offers this, or a conventional doctor can do this.
  • The Cyrex panels, which will show gluten and food cross-reactions, and various autoimmune markers.
  • The histamine whole blood is a useful test to see if you have high histamine/histadelia or low histamine/histapenia. This is offered by Vitamin Diagnostics and must be WHOLE blood.
  • Spectracell shows vitamin and mineral deficiencies.
  • A VAP test. If you have concerns about high cholesterol and heart disease, this is going to measure particle size, fibrinogen, Lp(a) and other cardio markers (since looking at only high total cholesterol is not particularly useful).
  • The OAT/Organic Acid Test. Great Plains offers this and it has markers of digestion, yeast overgrowth, infections, B vitamin status and neurotransmitter function.
  • A hair mineral analysis. This is a great way to look for toxic metals and mineral status. You want to look at ratios, not just levels. This is a good marker for copper toxicity as well. Analytical Research Lab offers this test.
  • If you think your copper is too high, or you’ve got low zinc, you can measure copper or ceruloplasmin. This is in serum.
  • Porphyrin testing. This is a measure of the effect of heavy metals such as lead and mecury. Kris Homme talked about this in Season 2 of the Anxiety Summit: Your hidden mercury burden – A likely root cause of the other root causes of anxiety – part 2
  • An amino acid profile, which is a plasma or blood spot test. It’s not something that I use very often, but I have seen people with this test.
  • You can also test candida antibodies in blood, which is not terribly accurate, but sometimes will show up.

I want to look into the following testing:

What functional/nutritional testing have you had done and have found to be helpful? Which of the above tests would you like more detailed information about?

The Anxiety Summit – Your hidden mercury burden: A likely root cause of the other root causes of anxiety – part 2

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Kris HommeQuote_Anxiety2

Kris Homme, MPH retired engineer turned science writer was interviewed by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

Your hidden mercury burden: A likely root cause of the other root causes of anxiety – part 2

  • how to get rid of your mercury burden: dental amalgams, mercury in fish
  • how a special diet can help
  • important supplements to include: antioxidants; essential fatty acids; minerals
  • foods and supplements to avoid
  • concerns around chelation
  • chronic mercury poisoning resources

Here is a snippet from our interview:

I’d really like to emphasize the toxicity of mercury and just how insidious it is and how important prevention is because, once you have toxicity, it can be pretty hard to get rid of. The first thing to do is address your exposures, and one big one is dental amalgams. If you are inclined to think you may have a mercury burden, then consider safe dental amalgam removal. It’s not an emergency, but put it into your five-year plan. You can read about this on IAOMT/ International Academy of Oral Medicine and Toxicology web site. They’re the pro-science dental association that has been working to fund and disseminate the science since 1983. They have developed a safe amalgam removal protocol. You can find a dentist who appreciates the toxicity of mercury and takes every precaution. Your old dentist may have an office full of mercury vapor, so you may want to find a new dentist and discuss the details of the procedure with the new dentist and decide for yourself whether the procedure is adequate. You got into trouble by trusting your old dentist to do what the old dentist thought was right, so it’s a good idea not to trust, but to figure out what you think is the right protocol for amalgam removal

Kris asked the following in the interview:

if you believe that your dental amalgams have affected your health, please report this to the FDA on the FDA MedWatch web site. They have a form to report adverse events, and dental amalgams are considered a medical device, so if you’ll use that form, it may help. In the last go-round against the FDA’s amalgam rule, the 2009 statement by the FDA said that they had received very few adverse event reports on amalgam, so let’s not let them say that again.

Here is the Environmental Working Group January 2014 report we mentioned: US Seafood Advice Flawed on Mercury, Omega-3s

Kris has some additional fish information here – Fish mercury: Some inconvenient truths

Here is short video of Kris talking about genetic susceptibility to mercury toxicity

This was a 2-part interview – here is the link to the blog for part 1

Here are links to the resources Kris shared:

Amalgam Illness by Andrew Cutler

Mercury Exposure

DAMS – Dental Amalgam Mercury Solutions

IAOMT/International Association of Oral Medicine and Toxicology

Kern 2012 article on brain pathology in mercury poisoning: Evidence of parallels between mercury intoxication and the brain pathology in autism

Kris’s website MercuryandMore

Kris’ paper published earlier this year: New science challenges old notion that mercury dental amalgam is safe

Here is a link to part 1 of this mercury discussion – chronic mercury poisoning effects at the molecular level, the cellular and organ level, effects on hormone imbalance and neurotransmitters and how to test.

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here www.theAnxietySummit.com

The Anxiety Summit – Your hidden mercury burden: A likely root cause of the other root causes of anxiety part 1

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Kris Homme

Kris Homme, MPH retired engineer turned science writer was interviewed by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

Your hidden mercury burden: A likely root cause of the other root causes of anxiety – part 1

  • chronic mercury poisoning effects at the molecular level: blocks enzymes, displaces minerals
  • chronic mercury poisoning effects the cellular and organ level: mineral transport, destroys barriers like gut and brain, mitochondrial dysfunction
  • effects on hormone imbalance, blood sugar regulation, food sensitivities, GABA/serotonin levels, autoimmunity
  • why mercury toxicity is complicated and hard to test for
  • subjective signs of chronic mercury poisoning

Here are some snippets from our interview:

Mercury inhibits methylation, which is the biochemical process that affects the production of many hormones and neurotransmitters. It also causes a selective loss of Purkinje neurons in the brain which produce GABA.

Mercury is known to concentrate in glands, including the thyroid and blocks the enzyme that converts T4 to T3. Also, your mercury burden is a chronic stressor that seems to provoke symptoms of adrenal fatigue.

Erethism: It’s the mercury personality, and that involves excessive timidity, diffidence, shyness, conflict avoidance, loss of self-confidence, anxiety, a desire to remain unobserved and unobtrusive a pathological fear of ridicule and explosive loss of temper when criticized. There are different versions of this definition and they’re all fun and they really resonated with me, so that can be interesting to look that up on the internet.

Here is the link to Kris Homme’s publication in Biometals, published earlier this year: New science challenges old notion that mercury dental amalgam is safe

Kris has gathered some additional information into this document – Chronic mercury poisoning: A brief summary of the science

It was lovely to recently meet Kris. After enjoying a nice cup of herbal tea with her, she shared a few things about mercury toxicity in her pretty back garden. Here is one of the videos we did – enjoy!

Here is a link to part 2 of this discussion- what to do and additional resources.

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here www.theAnxietySummit.com