liver

The liver/thyroid/serotonin and liver/GABA/progesterone connections: The Anxiety Summit 6

September 30, 2020 By Trudy Scott 10 Comments

Dr. Ameet Aggarwal is one of my guest experts on The Anxiety Summit 6: Toxins/Meds/Infections!
and our topic is Liver Function and Bile: Anxiety, Detox, the Gut and Hormones. Here is some of what we cover in our interview:

The liver/anxiety connections: thyroid/serotonin, microbiome and GABA/progesterone
Foods and nutrients like NAC, triphala, turmeric, taurine and lycopodium
Gilbert’s syndrome and schizophrenia; misophonia; family constellations therapy; giving and endorphins

and much more.

We discuss a number of the mechanisms as to why poor liver function affects your mood. There is the liver/thyroid/serotonin connection, and the liver/GABA/progesterone connection.

In the discussion on the liver/thyroid/serotonin connection and anxiety, Dr. Ameet shares from this paper – The Relationship between the thyroid gland and the liver (paraphrased as I don’t yet have transcripts):

Thyroxine and tri‐iodothyronine are essential for normal organ growth, development and function
These hormones regulate the basal metabolic rate of all cells, including hepatocytes, and thereby modulate hepatic [liver] function
The liver in turn metabolizes the thyroid hormones and regulates their systemic endocrine effects.
Thyroid dysfunction may perturb liver function
Liver disease modulates thyroid hormone metabolism.

The catecholamine and thyroid interrelationship is well recognized but less is known about the serotonin and the thyroid. Dr. Ameet shares the synergy between the thyroid hormones, serotonin and mood:

animal studies shows that the thyroid economy has a modulating impact on the brain serotonin system
studies in hypothyroid patients have shown that thyroid replacement therapy improves serotonin production

In summary, if we have compromised liver function and/or low thyroid function this may impact serotonin levels and lead to increased anxiety.

Here is a snippet from our discussion on the liver/GABA/progesterone and anxiety:

We often think about mental health as being neurotransmitters alone but it also depends on hormones. Progesterone affects how GABA works in the brain.
GABA is your anti-anxiety neurotransmitter but it requires progesterone to work well in your brain and your liver metabolizes all your hormones through phase 1 and phase 2 detoxification
If your liver is compromised then you’re likely to have lower progesterone levels and estrogen dominance.
With low progesterone GABA won’t work as well as well in the brain, leading to anxiety and insomnia.

Again, if we have compromised liver function this may impact progesterone levels, having an effect on how GABA works and causing increased anxiety.

If you recall, I shared this GABA/progesterone snippet a few weeks ago before the site was ready and now it’s ready for you to register.

This interview is one of the registration gifts so you can listen to it right away as soon as you register (there will also be a complimentary transcript made available as soon as it’s completed.)

Here is a little about the summit… as you know, anxiety can be related to your daily life experiences BUT it can also be triggered by:

foods you eat and what you drink (like wheat, oxalates, alcohol and more)
environmental toxins (like lead, plastics, fragrances, insecticides, fluoride and more)
many types of medications (like the birth control pill, acne medication, fluoroquinolone antibiotics and more) and/or
chronic infections (like Lyme disease, PANDAS, parasites, candida and more).

Once you identify the root causes and understand anxiety’s mechanisms you can support the liver/gallbladder, detox, address infections, implement targeted and supportive solutions, and get relief!

WHY ATTEND?

This is my 6th Anxiety Summit, featuring all new topics and the latest research related to anxiety and toxins, medications and infections.

I’ve also experienced many of these health challenges myself – lead and mercury toxicity, gluten issues and candida – and I’m currently dealing with chronic Lyme disease and dietary oxalate issues. You’ll hear some of my healing journey and my solutions in a few interviews too.

WHAT SETS THIS ONLINE EVENT APART?

What sets this apart from other events on toxins and infections is being able to make the many connections to GABA (the main calming neurotransmitter) and serotonin (a happy and calming neurotransmitter) AND how to use the amino acids GABA and tryptophan to ease your anxiety right away while you are dealing with the other underlying root causes – which take longer to address.

You will see this woven into each of the expert interviews (just like this one with Dr. Schaffner) and also addressed in detail in my 3 interviews where I do a deep dive into specific applications.

For example, in my toxins interview, I share how GABA reverses fluoride-induced anxiety and hypothyroidism, and how tryptophan and vitamin C ease anxiety symptoms associated with lead toxicity (I’ll be sharing more about this in the future so stay tuned….)

Over the course of the next 6 weeks you’ll be seeing frequent emails from me with snippets and highlights from various interviews – like this one. I do hope you continue to enjoy them and get excited about the summit! Please do share if you know someone who has anxiety!

It’s been wonderful to get all the emails saying how excited you are and seeing so many of you signing up. These last few months have been full-time on research and interviews and I’ll shortly get to share it all with you!

You’ve heard me say the Anxiety Summit has been called “a bouquet of hope!” My wish for you is that this summit is your bouquet of hope!

I hope you’ll join me and these incredible speakers, be enlightened and find YOUR solutions!

Here’s to no more anxiety and you feeling on top of the world again!

If you’re already familiar with some of this information and practice some of this already please share how it’s helped you. That way we can all learn.

If you’d like to ask a question, please post in the comments below.

I’d also love to hear from you once you’ve listened to this interview. Please do come back and comment about some of the highlights of this interview and what changes you plan to make.

Even if you already receive my newsletters and signed up some time ago to be notified about the upcoming Anxiety Summit 6, you will still need to register at the new link here, because Health Talks Online is doing the production and backend work for me.

If you don’t register you won’t get access to the daily summit emails with all the interviews.

You will however, continue to get these emails from me.

This is my 6th Anxiety Summit and it is all new content!

The content is research-based and practical, and is geared to anxious individuals who are health-savvy and to practitioners who work with anxious individuals.

If you are totally new to functional medicine and nutritional solutions for anxiety, you will still learn so much so just take in what you can and know you’ll get all this eventually.

PQQ for Stress, Sleep, Mitochondria and Gut Health with Dr. Michael Murray: The Anxiety Summit 5

October 28, 2019 By Trudy Scott 4 Comments

Michael Murray, ND is one my guest experts on The Anxiety Summit 5: Gut-Brain Axis and our topic is: PQQ for Stress, Sleep, Mitochondria and Gut Health. What You’ll Learn –

Pyrroloquinoline quinone (PQQ) for calm energy – what it is and how to use it
How it is protective against every known toxin
A study where participants report “improved happiness and fullness of social life”

Pyrroloquinoline quinone (PQQ) is a fascinating nutrient that provides calm energy, helps with sleep, is protective against every known toxin and support mitochondrial health. PQQ also supports digestive health because the liver and gut is mitochondria-dense (Tara Hunkin shares more about this in her mitochondria/anxiety interview).

When I discovered that Dr. Michael Murray, ND is an expert on PQQ I reached out to invite him to speak on the summit. I was not disappointed – our interview is fabulous, meaty and exciting.

(We actually ended up doing it twice because of technical issues with the first one. There are always plenty of “fun and games” when hosting a summit!)

Dr. Murray shares some of the many benefits of this vitamin-like compound that is found in kiwi fruit, leafy green vegetables, papaya and other fruits and vegetables:

It’s been shown to be neuroprotective, protecting brain cells, it promotes nerve growth factors, it’s been shown to be memory restorative in animal and human studies. It has some interesting effects on anxiety and improving sleep quality. And it exerts many synergistic effects with Coenzyme Q10 and some of the other nutritional compounds that influence the mitochondria.

He feels that “eventually, PQQ is going to be recognized as essential for human nutrition.” And in case you’re curious about the pronunciation, this is how you say it: pyrro-lo-quin-o-line quinone.

We discuss this paper: “Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep” and Dr. Murray shares how PQQ is

really quite interesting because normally when we think of substances exerting an anti-stress or an anti-anxiety effect, we think about things that maybe calm us down and maybe even make us a little tired.

PQQ is able to promote a calming effect, an anti-stress effect, an anti-anxiety effect, but it actually enhances mental energy and physical energy.

The results in the study were pretty profound and I quote some of the findings the study authors report participants experienced (this, of course, was subjective feedback):

Fullness of social life improved
Happiness and fullness in the family life improved
Fullness and satisfaction in overall daily improved

They also found improved quality of life on measures of appetite, and pain, and obsession, as well.

The authors have this conclusion about a possible mechanism: “The anti-oxidative capacity or mitochondrial biogenesis function of PQQ might be responsible for the outcomes in this study.”

Some of the other topics we discuss around PQQ:

why taking PQQ is likely a better approach than using resveratrol
how it compares with vitamin C in terms of being an antioxidant (this really amazes me)
how it “been shown to protect against every known toxin on the brain”
possible benefits for Parkinson’s disease (by preventing the formation of alpha-synuclein) and also for Alzheimer’s disease
how “PQQ influences the microbiome in a very favorable way”
how a single dose, used one time, dramatically reduced C-reactive protein (a marker of inflammation) in one study
possible concerns about oxalates
optimal dosages and when to use it with coenzyme Q10
best products and much more

Be sure to listen to Tara Hunkin’s interview to get a solid understanding of the bidirectional connection between mitochondria and anxiety: Mitochondrial Dysfunction in Anxiety

Please join us and listen to this interview and all the others on The Anxiety Summit 5: Gut-Brain Axis.

When you register now you’ll get access to there 3 interviews right away:

Fix the Brain to Fix the Gut – Datis Kharrazian, DHSc, DC, MS, FACN, CNS
MTHFR, B12 Genes and Anxiety – Carolyn Ledowsky, ND
Why Bile is the Key to Anxiety & Hormone Havoc – Ann Louise Gittleman, PhD, CNS

If you have already signed up for the summit, I hope you enjoy these interview highlights.

If you have yet to sign up, please do come and join us and learn.

If you’re considering purchasing the summit to keep for your learning library, you have a number of options that include:

Online only or flash drive or both
A PDF or printed transcripts of all the interviews
The Best of Anxiety-Gut interviews from previous Anxiety Summits
GABA Quickstart Program (a group program with me on how to actually use GABA for your physical anxiety, with a private Facebook group and live Q & A call)

Purchase options

Have you already used PQQ and found good results? Please share so we can all learn.

I’ll be reporting back more in the coming weeks and months based on my own personal findings and based on feedback from my clients and my community. I’ve already had this feedback from someone who has seen the speaker line-up:

Registered for the summit today. So excited about it. And excited to see PQQ, one of my favourite, must-have supplements, getting its own piece.

If you’d like to give feedback or ask a question, please post in the comments section at the bottom.

I’d also love to hear from you once you’ve listened in to Dr. Murray’s interview and the others.

Mitochondrial Dysfunction in Anxiety with Tara Hunkin on The Anxiety Summit 5

October 18, 2019 By Trudy Scott 2 Comments

Tara Hunkin, NTP, CGP, RWP is one my guest experts on The Anxiety Summit 5: Gut-Brain Axis and our topic is: Mitochondrial Dysfunction in Anxiety. In this interview you’ll learn:

The role of mitochondria in the gut, brain and anxiety
Causes (such as medications and environmental toxins), testing, and signs and symptoms of mitochondrial dysfunction
Healing nutrients: Carnitine, COQ10, folinic acid, meal timing (as well as antioxidants and many other nutrients such as PQQ)

Tara starts with an overview of mitochondria, the energy powerhouses of our bodies and why they are so important in both physical and mental health.

You can hear some of this background information in this short in-person interview we did in San Diego recently.

You’ll also hear Tara share about this new bidirectional relationship that has been identified between anxiety and mitochondrial dysfunction. One of the papers she is referring to this very recent 2019 review paper: Anxiety and Brain Mitochondria: A Bidirectional Crosstalk. Here are the highlights:

Despite the established link between mitochondrial dysfunction and various psychiatric disorders, the contribution of mitochondria in anxiety disorders has not been extensively addressed.
Mitochondria are emerging as modulators of anxiety-related behavior, as evidenced both in animal and human studies.
There is a bidirectional link between mitochondria and anxiety. Mitochondrial, energy metabolism, and oxidative stress alterations are observed in high anxiety; conversely, changes in mitochondrial function can lead to heightened anxiety.

Tara shares how important the mitochondria are when it comes to digestion and gut health too:

the liver is heavily mitochondrial-dense and is needed to help eliminate toxins we are exposed to (toxins that affect our mitochondria and increase anxiety)
the mitochondria are also important when it comes to digestion – the lining of digestive tract (the epithelial cells of the microvilli) contain large numbers of mitochondria

The authors also highlight that “Pharmacological manipulation of mitochondria may be a potential therapeutic approach to relieve high anxiety symptoms.” One of the objectives of this summit is to highlight non-pharmacological approaches and Tara does exactly this in our interview.

She covers both lifestyle and nutritional approaches for addressing mitochondrial dysfunction (acetyl-l-carnitine, glutathione, antioxidants, coenzyme Q10, folinic acid and many more).

I also mention two other interviews on the summit where we talk about nutrients that also support mitochondrial function: PQQ (pyrroloquinoline quinone) and TUDCA (tauroursodeoxycholic acid).

Be sure to listen to these interviews for more about these two nutrients:

Jay Davidson, DC, PScD: Parasites, Anxiety and TUDCA for Your Liver
Michael Murray, ND: PQQ for Stress, Sleep, Mitochondria and Gut Health

We also discuss testing and all the environmental factors that impact the mitochondria including medications such as risperidone/risperdal (and antipsychotic medication), valproic acid (used for seizures), fluoroquinolone antibiotics like Cipro (and others) and also benzodiazepines (the commonly prescribed anti-anxiety medications).

Please join us and listen to this interview and all the others on The Anxiety Summit 5: Gut-Brain Axis.

When you register now you’ll get access to there 3 interviews right away:

Fix the Brain to Fix the Gut – Datis Kharrazian, DHSc, DC, MS, FACN, CNS
MTHFR, B12 Genes and Anxiety – Carolyn Ledowsky, ND
Why Bile is the Key to Anxiety & Hormone Havoc – Ann Louise Gittleman, PhD, CNS

If you have already signed up for the summit, I hope you enjoy these interview highlights.

If you have yet to sign up, please do come and join us and learn.

If you’re considering purchasing the summit to keep for your learning library, you have a number of options that include:

Online only or flash drive or both
A PDF or printed transcripts of all the interviews
The Best of Anxiety-Gut interviews from previous Anxiety Summits
GABA Quickstart Program (a group program with me on how to actually use GABA for your physical anxiety, with a private Facebook group and live Q & A call)

Purchase options

If you’d like to give feedback or ask a question, please post in the comments section at the bottom.

I’d love to hear from you once you’ve listened in to this interview and the others.

Drainage and liver-bile duct-gallbladder support for Lyme disease

May 24, 2017 By Trudy Scott 4 Comments

Dr Jay Davidson, host The Chronic Lyme Disease Summit 2 shares the powerful story of how he became a Lyme expert because of his own wife’s crash with Lyme disease when their daughter was born. I just love that he offers hope:

there is actually hope out there no matter how much crud you’ve been through and how many crazy things you went through

He shares the 5 steps from his book: 5 Steps to Restoring Health Protocol

Step one is detect, and that’s all about figuring out what are all the pieces to the puzzle. Because if we can’t figure out what the pieces are, we can’t create a road map of where we need to go, right.
The second step is drain. And I want to talk a lot about that today, because that’s something I believe that can improve any protocol, any treatment that you’re going through; drainage, drainage, drainage.
Step three is elimination or pathogen elimination or if you just want to think of it as like killing pathogens.
Step four is about rebuilding tissues, and it’s very dependent on what’s going on with your body as to where we need to focus with rebuilding the tissues.
Step five is detoxification.

And goes into what drainage is and why it’s so important when it comes to Lyme disease, heavy metal detox and healing in general:

Drainage, I think more of the pathways. So you could say, okay, what are the pathways? I think of the colon, like going number two, pooping, that’s a pathway. So if you are not going number two at least once a day, if not twice a day, and having good bowel movements then that’s a sign that drainage pathway is not open.

The kidneys are drainers; the skin, just the ability to sweat; the liver-bile duct system; the brain; lymphatic system; these are all drainers.

And so if we focus on the idea of draining just to make sure these pathways are open and moving. Then when we get to a point where we’re going to kill bugs or kill pathogens and/or detoxify toxins, heavy metals – get these things out of our body – if the drainage pathways are open, the body does well.

If the drainage pathways are clogged, then that’s when these things can’t move – like the metals, these pathogens like Lyme – they can’t move out of the body. So therefore, the debris or the chemical creates inflammation, and that’s what makes us to have these reactions. We call them Herxheimer reactions.

Dr Jay goes into more detail on the number one drainage area he focuses on with his patients – the liver-bile duct-gallbladder area and how it impacts:

the lymphatic system
stomach acid and digestion
exposure to pathogens

And he shares how to use ox bile, dandelion tea, activated charcoal, coffee enemas and castor oil packs to support the liver-bile duct-gallbladder area and improve drainage.

He’s also excited to share a liver support product that is new to me. It’s called TUDCA or tauroursodeoxycholic acid and I certainly look forward to learning more about it!

The Chronic Lyme Disease Summit 2 runs June 19-26, 2017 and Dr Jay’s interview airs on day 1 of the summit.

Lyme disease is quickly spreading across the entire globe – very few are enlightened on this troublesome condition! We know that 300,000+ people per year contract Lyme, and 2017 is predicted by some to be an incredibly risky year! And according to the CDC, every single year there are more people affected with Lyme disease than breast cancer. That’s why Dr. Jay Davidson is hosting the second summit on this topic with only 2 repeat speakers from 2016.

Last year I was interviewed on Lyme anxiety and how to use GABA and other amino acids to ease the anxiety while you are working on addressing the Lyme disease. I’m not speaking this year but last year’s summit was so good and very popular with my community so I want you to know about it in case your health challenges are due to Lyme disease. I’ve seen the line-up this year and I’m excited to learn from these experts.

This summit will help you understand symptoms (common and rare), diagnosis and testing, practical at-home health tips, healing protocol explanations and more!

So much of what you’ll learn on this summit is applicable for you if you have Lyme BUT much of it will be valuable if you’re dealing with any health issue (like this drainage interview).

Feel free to post questions or feedback below.

The Anxiety Summit – Primal nutrition for anxiety and depression

November 16, 2014 By Trudy Scott 1 Comment

Dr. Lauren Noel, ND was interviewed by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

Primal nutrition for anxiety and depression

The benefits of eating grass-fed red meat
Which healthy fats to include and why
Why include nutrient-dense bone broths and how to make them
Mineral-rich foods make a difference

Here is the blog post from season 1 of the Anxiety Summit: The Research – Food to prevent and treat anxiety and depression?

out of every single dietary food grouping that I looked at including vegetables, fruits, salads, beans, etc the strongest correlate of mental health was red meat intake (grass-fed red meat of course)

I’m glad we talked about total cholesterol that is too low because the whole cholesterol question comes up a lot. Here is a blog post with some links to studies: Total cholesterol that is too low: anxiety and depression in women

Here is some research on how trans fats make us depressed and anxious

Here is my roasted spicy pumpkin seed recipe and Magdalena’s liver pate recipe

If you can’t get your meat locally, you can mail order grass-fed meat and other wonderful products like liver and pemmican from US Wellness Meats. In the interview I mentioned their Liverwurst, which is a mixture of grass-fed beef trim (30%), liver (30%), heart (20%) and kidney (20%). I really think this “is the tastiest way to incorporate healthy grass-fed beef organs into your diet!” All of their beef products are 100% grass-fed and grass-finished. They source from family farms, and endorse sustainable farming and humane practices.

Dr. Lo is the host of Dr. Lo Radio, a top rated podcast on iTunes that has attracted over 1million listens. It’s a great podcast. Here are links to 2 shows: Death by Food Pyramid with Denise Minger and Your Personal Paleo Code with Chris Kresser

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here www.theAnxietySummit.com

The Anxiety Summit – The hidden master organ: Why treating your liver is fundamental to anxiety and depression

November 6, 2014 By Trudy Scott 32 Comments

Dr. Ameet Aggarwal ND psychotherapist and author of Feel Good: Easy Steps to Health and Happiness was interviewed by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

The hidden master organ: Why treating your liver is fundamental to anxiety and depression

Why the liver is the hidden master organ and defining a sluggish liver
The role of lactate and the liver and how this contributes to anxiety
How the liver affects thyroid hormones
Dietary factors that improve the liver and the ones that make it more sluggish
A form of breathing that massages the liver
Homeopathics, antioxidants and herbs for a sluggish liver
The benefits of using a castor oil pack
The importance of organic psychotherapy, family constellations, de-stressing, meditation, and exercise

Here are some snippets from our interview:

We call the liver the master organ because it’s really responsible for most of the functions in your body, including blood purification, detoxification of drugs and toxins, and also detoxifies the toxins that are produced by your body itself. The liver also creates a lot of enzymes, produces bile, so it’s responsible for a lot of your digestion, hormone production, protein production, and it also helps with blood sugar storage and regulation. Not only that, it helps with immune cell activation and storage of vitamins and iron.

When you have a sluggish liver, less bile is produced and digestion is poor leading to constipation, toxin buildup, inflammation and less absorption of important nutrients. You can then have neurotransmitter deficiencies and be more susceptible to anxiety.

Your liver also controls hormones, so if your liver is imbalanced, you will see a progesterone deficiency and usually estrogen dominance. As you know, Trudy, progesterone deficiency directly affects the function of GABA in your brain, and so with liver qi stagnation, leading to progesterone deficiency, we will see increased levels of anxiety.

Here is the Neuropsychopharmacology paper called Neural pathways underlying lactate-induced panic where they connected high lactate levels to panic attacks. We discussed how sugar, alcohol, caffeine, food sensitivities, low levels of niacin and vitamins B6 may contribute to elevated levels of lactate in the blood.

Here is the paper that addresses the liver-thyroid connection: The relationship between the thyroid gland and the liver. Basically, thyroid hormones are processed by the liver. Some of the conversion of T4 into active T3, which is a thyroid hormone, requires healthy liver function.

Ameet shared this at the end of our interview and I want to share it here because I’m inspired by what Ameet is doing, because I love Africa and Kenya (my husband and I honey-mooned there) and because I’d love to inspire you to get involved and consider a trip to Kenya (why not!):

I actually live at the bottom of Mount Kenya right on the equator, a little town called Nanyuki. My dream was to come back to Kenya after Canada to start mobile clinics for remote communities and supervise students and doctors from around the world, which I started through a program called FIMAFRICA/Foundation for Integrated Medicine in Africa. Basically, we go to remote villages that don’t have medical services and treat them for chronic diseases or acute diseases using naturopathic medicine, mainly homeopathic medicine, which works really well, because a lot of these communities suffer from just a lot of chronic disease but all they’re given is antibiotics or antimalarials, which don’t necessarily treat the root cause of the issue. So, they love homeopathy because a lot of chronic disease is disappearing, and they really notice the difference between the two types of medicine. So it’s my passion, and yeah, I hope to continue doing it for the rest of my life. My aim is hopefully one day to sell a million copies of my book and just do mobile clinics all day.

Watch this short video of Ameet talking about it and then tell me you’re not excited about the idea of going to Africa and getting involved!

If you want to help, check out the FIMAFRICA site above, contact him about going there and volunteering or buy a few copies of his great book Feel Good: Easy Steps to Health and Happiness

Here is a nice video of Ameet giving an overview of Feel Good

And get your free chapters from the Feel Good book (on emotions, better sex and liver health)