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DLPA

An amino acid supplement with DLPA, glutamine and 5-HTP eases alcohol withdrawal symptoms at an inpatient detoxification program

April 8, 2022 By Trudy Scott 11 Comments

amino acid and alcohol

An amino acid supplement with DLPA, glutamine and 5-HTP (and a few other nutrients) eases alcohol withdrawal symptoms at an inpatient detoxification program. Other than anxiety (I’ll share more on this below), there was also a significant decrease in psychiatric symptoms. Here is an excerpt from the study, The use of a food supplementation with D-phenylalanine, L-glutamine and L-5-hydroxytriptophan in the alleviation of alcohol withdrawal symptoms:

We described the use of a food supplementation with D-phenylalanine, L-glutamine and L-5-hydroxytryptophan in the alleviation of alcohol withdrawal symptoms in patients starting a detoxification therapy.

Since abstinence from ethanol causes a hypodopaminergic and a hypoopioidergic environment in the reward system circuits, manifesting with withdrawal symptoms, food supplements that contains D-phenylalanine, a peptidase inhibitor (of opioid inactivation) and L-amino-acids (for dopamine synthesis) were used to replenish a lack in neurotransmitters and alleviate the symptoms of alcohol withdrawal.

First I cover some translation issues and then more about the actual product and study results. I also share my commentary on the amino acids and dosing used in the study (and the fact that anxiety did not resolve). I include how to apply this information if you have a loved one in an alcohol treatment/rehab program or if you recognize social drinking is an issue for you. And I wrap up with additional resources if you are new to using GABA as a supplement, the GABA Quickstart online program and the practitioner training.

The study was completed and published in Slovenia and there are a few translation issues I’d like to clarify:

  • The study title states D-phenylalanine (DPA) was in the amino acid product, however DL-phenylalanine (DLPA) was actually used. You can read about the difference between DPA and DLPA here. In summary, DPLA works on both dopamine and endorphin support and DPA works on endorphin support only.
  • As you can see from the excerpt above, hypodopaminergic refers to low dopamine and hypoopioidergic refers to low endorphins. During withdrawal from ethanol/alcohol, both low dopamine and low endorphins cause withdrawal symptoms.
  • L-5-hydroxytryptophan is incorrectly spelled as L-5-hydroxytriptophan and reward system is incorrectly spelled as reword system. (Clarifications are provided for facilitating online searches in the research literature.)

More about the product, the study and the conclusion

It was a small randomized, double blind study with just 20 patients and the amino acid product was used for 40 days of the inpatient alcohol detox or rehab program.

This is the actual combination product used:

300 mg DLPA

150 mg glutamine

5 mg 5-HTP

1 mg  vitamin B6

50 mg calcium gluconate

25 mg magnesium oxide

0.01 mg folic acid

Psychiatric symptoms were measured using the SCL- 90R and included assessing for “somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid, and psychoticism.” During their rehab there was a significant decrease in these categories of psychiatric symptoms in the study group, except for their anxiety symptoms.

The authors conclude that “abstinence causes a major stress for the patients. The use of a food supplement containing D-phenylalanine [it was actually DL-phenylalanine], L-glutamine and L-5-hydroxytryptophan alleviates the withdrawal symptoms.”

As expected, once alcohol consumption was stopped, cortisol levels, liver enzymes and total bilirubin all decreased in the study group and the control group.

My commentary on the amino acids and dosing used in the study (and the fact that anxiety did not resolve)

Keep in mind the same dosing was used for all study participants. What I use clinically with folks with low levels of these neurotransmitters, is an individualized approach based on each person’s needs, for endorphin and dopamine support (from the DLPA), blood sugar support (from glutamine) and serotonin support (from 5-HTP). This means identifying symptoms in each category and doing a trial of each respective amino acid, starting low and increasing based on symptom resolution.

Given that anxiety symptoms didn’t resolve in the study group, I would have loved to see the amino acid GABA included, also dosed according to individual needs. GABA helps ease the physical tension-type anxiety and low GABA tension often drives the need to self-medicate with alcohol in order to relax and fit in socially.

The authors do mention GABA too: “the physiological craving for alcohol may be the result of a deficiency of the naturally occurring opiate like substances as well as other neurochemical deficits (i.e., dopaminergic, GABAergic, and serotonergic).

Also, an animal study shows that GABA helps with gut damage caused by alcohol consumption, so there is this additional benefit.

A higher dose of glutamine and/or 5-HTP may have also helped ease anxiety. They used 150 mg glutamine whereas a typical starting dose for glutamine is 500 mg (and we increase from there). Going up to 1000 mg to 1500 mg three or 4 times a day is not unusual and is typically very beneficial for alcoholics – for blood sugar stability, an additional calming effect and for healing the leaky gut which has been damaged by the alcohol consumption.

With regards to 5-HTP, they used 5 mg 5-HTP which is considered extremely low. I wonder if it was in fact 50 mg, which is a typical starting dose? Going up to 150 mg 5-HTP use 2 or 3 times a day is not unusual. Serotonin support with 5-HTP (or tryptophan) is very beneficial for the worry-type of ruminating anxiety.

For some individuals DLPA may have been too stimulating and contributing to anxiety via a dopamine boost. For these individuals, DPA may have been a better option for endorphin support.

I am not in favor of folic acid and prefer methylfolate, and although magnesium is an important cofactor for neurotransmitter production, magnesium oxide does not provide much usable magnesium.

Outside of the amino acids and other nutrients used, a vitamin B1 (thiamine) deficiency would need to be addressed and any other deficiencies (such as all the B vitamins, zinc, vitamin D, magnesium etc.) caused by chronic alcohol consumption. This is not a comprehensive list and a full functional workup will help to identify all possible deficiencies.

Despite my quibbles, the outcome of the study is very encouraging, I appreciate the researchers and I hope to see it replicated and refined in other settings.

How to apply this information if you have a loved one in an alcohol treatment/rehab program

Unfortunately the amino acids are seldom incorporated at in-patient detox and rehab centers but they should be. Your options are to:

  • Share this study and my blog with the treatment center
  • Educate yourself (on using the questionnaire and doing the amino acid trials) so you can use them with your loved one once rehab is over. This is key for preventing a relapse and for swapping alcohol addiction for sugar or caffeine or nicotine addiction.
  • Introduce one amino acid at a time so you can figure out which one/s they need and how much
  • Read my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, and share a copy with the treatment center (and your loved one and their treatment team)
  • Address diet, nutritional deficiencies and gut health

Keep in mind that the amino acids are used with success for cocaine, heroin and other drug addictions.

How to apply this information if you recognize social drinking is an issue for you

New research shares that “low-level alcohol consumption is commonly perceived as being inconsequential or even beneficial for overall health, with some reports suggesting that it may protect against dementia or cardiovascular risks”, however, as the authors suggest “even low-level alcohol consumption is associated with premature brain aging.”

Social drinking is the norm and is way too prevalent. And it’s often used as a calming measure in order to relax and fit in socially.  If this sounds like you:

  • Educate yourself (on using the questionnaire and doing the amino acid trials) so you can use them to quit drinking easily with no willpower and no feelings of being deprived. This is key for preventing the swapping out the need for alcohol (to relax or fit in socially) with a sugar or caffeine or nicotine addiction. In this case, GABA helps a young man who has recently given up alcohol, Adderall and nicotine.
  • Introduce one amino acid at a time so you can figure out which one/s you need and how much
  • Read my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, and share a copy with your loved one/spouse/partner and practitioners/therapists.
  • Address diet, nutritional deficiencies and gut health

Resources if you are new to using the amino acids as supplement

If you are new to using the amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the low neurotransmitter symptoms).

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the team you or your loved one is working with.

There is a section on alcohol but keep in mind that all the sections on sugar craving/addiction apply to alcohol addiction and self-medicating with alcohol too. Some individuals use alcohol to numb out and some use sugar. Many use both and once alcohol addiction is addressed, it’s often replaced with sugar and caffeine addiction. This is why addressing neurotransmitter imbalances is key.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If you don’t feel comfortable reading my book and figuring things out on your own (doing the symptoms questionnaire and doing respective trials), you can get guidance from me in the GABA Quickstart Program (online/virtual).

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. It’s an opportunity to interact with me and other practitioners who are also using the amino acids.

Have you used amino acids with success as part of an alcohol detox program (for yourself or for a loved one)? Or to help stop social drinking of alcohol?

Which neurotransmitter imbalances were driving your need to self-medicate with alcohol and which amino acids helped?

If you’re a practitioner do you use the amino acids (via an individualized approach) to help with alcohol withdrawal and cessation with your patients and/or clients?

Feel free to ask your questions here too.

Filed Under: 5-HTP, Addiction, Amino Acids, Anxiety, DPA/DLPA, GABA, Glutamine, Tryptophan Tagged With: 5-HTP, alcohol, alcohol withdrawal symptoms, amino acid supplement, anxiety, B1, calming, d-phenylalanine, detox, dl-phenylalanine, DLPA, GABA, GABA Quickstart, glutamine, gut, hypodopaminergic, hypoopioidergic, inpatient detoxification program, L-5-hydroxytriptophan, L-glutamine, practitioner training, psychiatric symptoms, rehab, social drinking, tension, Thiamine, worry

DLPA (DL-Phenylalanine) eases PMDD/PMS symptoms in women who experience declining endorphin levels in the second half of their cycles

March 18, 2022 By Trudy Scott 17 Comments

dlpa

Mood swings, intense sugar cravings, comfort/binge eating, sadness, anxiety, crying, cramps and increased pain, irritability, anger, fatigue, cognitive dysfunction, overwhelm, feelings of unease and dissatisfaction, aggression, heartache, and/or insomnia are common for many women during the second half of the menstrual cycle i.e. in the luteal phase. You may relate to all or some of these symptoms. And you may have been diagnosed with or may identify with PMS (premenstrual syndrome) or PMDD (premenstrual dysphoric disorder – similar to PMS but more serious).

Research shows improvements of these symptoms with the amino acids tryptophan (which provides serotonin support) and GABA (which supports GABA levels). Although there is no research that the pyroluria protocol improves symptoms it’s something I see clinically all the time. (I’ve written about this extensively and share more on this below)

A really interesting study published in 1989 identified low endorphins and low catecholamines as a probable cause for some women – Prevention of Late Luteal Phase Dysphoric Disorder Symptoms with DL-Phenylalanine in Women with Abrupt β-Endorphin Decline: A Pilot Study

I recently came across the above paper and prior to this, had not considered this as a primary root cause. Here is the excerpt from the abstract:

Twenty-two women with late luteal phase dysphoric disorder were treated with DL-phenylalanine during the 15 days prior to menses in a double-blind crossover study.

DL-Phenylalanine was shown to be more effective than placebo in attenuating many symptoms characteristic of luteal phase dysphoric disorder. This amino acid was chosen because of its hypothesized actions in attenuating the symptoms associated with the sharp decline in central β-endorphin levels during the late luteal phase in women with luteal phase dysphoric disorder.

Let’s review a few terms… Late luteal phase dysphoric disorder is a synonym for PMDD. The luteal phase is one stage of the menstrual cycle and occurs after ovulation and before your period. When you feel dysphoric you feel very unhappy, uneasy, or dissatisfied. With the downward endorphin shift at this time, period pain and other pain can be worse, and weepiness and emotional symptoms increase. The need for comfort or reward eating also increases. The study authors suggest these PMDD symptoms may “closely resemble those seen during morphine or heroin withdrawal.”

Based on my experience I do feel comfortable extrapolating these findings to PMS and even peri and post-menopausal women who experience some or all of these symptoms (other than actual periods and period issues in post-menopausal women).

Study participants, dosing and timing of DLPA and improvements

The participants in the study were white, middle-class, and between 24 and 29. Each woman took one 750 mg of DLPA at breakfast and lunch for the 15 days prior to the expected onset of their periods.

In the study groups, it was found that “initial improvement started at the end of the first month of DLPA therapy. Continued therapy brought increased relief from symptoms by the end of the second month. Interestingly, the greatest period of improvement occurred during the washout period” at the end of the third month possibly due to a delayed action of DL-phenylalanine.

The authors make the following conclusion:

DL-phenylalanine was found to be safe, well-accepted, and without significant side effects. The significant improvement it produced with many of the symptoms characteristic of Late Luteal Phase Dysphoric Disorder [PMDD] suggests that it may prove a useful addition to the therapeutic armamentarium for this syndrome.

Keep in mind that a typical starting dose of DLPA is 500mg used 2-3 x per day and it’s typically used between meals for best effects. Ideal is also to customize dosing to your unique needs. In this study, everyone received the same dose at the same time. For these reasons it’s even more impressive to see results like they did.

It makes sense but I have just not used DPLA alone and only in the second half of the cycle

It’s a very small pilot study but given my experience with the amino acids DLPA, DPA and tyrosine, and the vast number of women I have worked with who had symptoms like the above, it makes sense. Using the above three amino acids in combination with dietary changes, tryptophan, GABA and the pyroluria protocol, this approach has offered relief for many of my clients. I have just not used DPLA alone and only in the second half of the cycle.

In case you’re wondering why I mention the three amino acids DLPA, DPA and tyrosine above, it’s because:

  • DLPA (the amino acid used in this study) supports both endorphins and catecholamines (dopamine is one of them)
  • Or DPA (supports endorphins only) can be used with tyrosine (supports catecholamines only) instead of DLPA which does both

I blog about the differences between DLPA and DPA here, together with all the symptoms we look at when considering doing a trial.

In this study, they used DLPA which boosts endorphins and catecholamines. As I share in my DPA vs DLPA blog, I prefer DPA (d-phenylalanine) for endorphin support when symptoms are severe. But DPA is not always available so DLPA is a good alternative, assuming the person can handle the catecholamine support. Some people can’t and there are some contraindications too.

I’d love to see follow-on research covering the following:

  • A larger group of women using DLPA
  • Individualizing the dosing of DLPA to each person’s unique needs
  • Correlating results with the low endorphin and low catecholamine symptoms questionnaire
  • Comparing DLPA alone with a combination of DPA + tyrosine (with each individualized based on unique needs)

Serotonin and GABA support for PMS/PMDD, and the pyroluria protocol

In this paper, Premenstrual Dysphoric Disorder the authors share that PMDD

comprises emotional and physical symptoms and functional impairment that lie on the severe end of the continuum of premenstrual symptoms. Women with PMDD have a differential response to normal hormonal fluctuations.

It’s recognized that serotonin and GABA play a role:

This susceptibility may involve the serotonin system, altered sensitivity of the GABAA receptor to the neurosteroid allopregnanalone [a naturally occurring neurosteroid which is made from the hormone progesterone], and altered brain circuitry involving emotional and cognitive functions.

They share SSRIs that are considered as the first-line treatment. Second-line treatments include oral contraceptives, calcium, chasteberry, and cognitive-behavioral therapy.

However, as I share in this blog, research supports the use of tryptophan – Tryptophan for PMS: premenstrual dysphoria, mood swings, tension, and irritability

A study published in 1999, A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria, tryptophan was found to reduce symptoms of PMS when used in the luteal phase or second half of the cycle (i.e. after ovulation).

I mention GABA in this blog and the fact that many anxious women I work with also have pyroluria or signs of low zinc and low vitamin B6 and adding these nutrients, together with evening primrose oil, provide additional hormonal and neurotransmitter support, and help with the social anxiety.

Resources if you are new to using DLPA (or other amino acids) as supplements

If you are new to using DLPA or the other amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see the low endorphin and low catecholamine symptoms.)

If you suspect low levels of endorphins and/or low levels of catecholamine and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the team you or your loved one is working with. Blog posts like this are intended to add value to the chapter on amino acids, which contains detailed information on doses and time of the day for dosing.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acid products that I use with my individual clients and those in my group programs.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. It’s an opportunity to interact with me and other practitioners who are also using the amino acids.

Have you considered that there may be different types of PMS (premenstrual syndrome) or PMDD (premenstrual dysphoric disorder) i.e. a different combination of root causes and therefore different solutions?

And have you had success with DLPA alone (providing both endorphin and dopamine support) or by using a combination of DPA (endorphin support only) and tyrosine (catecholamine support only).

If you’re peri or post menopausal have you also seen success with any of these amino acids?

Have the other amino acids, tryptophan and GABA or the pyroluria protocol helped too?

If you’re a practitioner please share what you’ve seen with clients/patients.

Feel free to ask your questions here too.

Filed Under: Amino Acids, Anxiety, Hormone, PMS, Women's health Tagged With: aggression, anger, anxiety, catecholamines, Cognitive dysfunction, comfort/binge eating, cramps, crying, dissatisfaction, dl-phenylalanine, DLPA, endorphin, fatigue, feelings of unease, GABA, heartache, increased pain, insomnia, intense sugar cravings, irritability, luteal phase. premenstrual syndrome, menstrual cycle, mood swings, overwhelm, PMDD, PMS, premenstrual dysphoric disorder, pyroluria, sadness, second half of their cycles, serotonin, tryptophan

What is the difference between DPA and DLPA (amino acids) and which one do I use for weepiness, heart-ache, pain and energy?

March 11, 2022 By Trudy Scott 23 Comments

dpa and dlpa

Today we address a very common question I get: “What is the difference between DPA and DLPA?” The follow-up question is this: “And what symptoms do they help with?” These are both amino acids that help to boost certain feel-good neurotransmitters. DPA (d-phenylalanine) supports endorphins, whereas DLPA (dl-phenylalanine) supports both endorphins (to a lesser extent than DPA) and catecholamines (to a lesser extent than tyrosine).

Depending on your imbalances and symptoms, they could help with weepiness, heart-ache, comfort eating, emotional support, pain relief, better focus and energy, and even improved motivation.  

I mostly recommend DPA (which I call a-hug-in-a-bottle) and share the reasons why below, but some people do really well with DLPA. It’s a matter of figuring out the best one and dose for your unique needs.

DPA for low endorphin symptoms

DPA (d-phenylalanine) is an amino acid that destroys the enzyme that breaks down endorphins. Endorphins are feel-good chemicals that you experience with an endorphin rush when you go for a run or when someone gives you a big hug, when you show kindness to someone or an individual does something nice for you.

Taking the amino acid, DPA, as a supplement helps to raise your endorphins and helps when you feel weepy and overly emotional and reduces the need to self-medicate with treats as a reward or for comfort.

This amino acid is a favorite with so many of my clients and community because it makes them feel so lovely … a warm and fuzzy feeling. I often call it a-hug-in-a-bottle!

Here are the low endorphin symptoms I have my clients rate if they are considering a trial of DPA:

  • Heightened sensitivity to emotional pain
  • Heightened sensitivity to physical pain
  • Crying or tearing up easily
  • Eating to soothe your mood, or comfort eating
  • Really, really loving certain foods, behaviors, drugs, or alcohol
  • Craving a reward or numbing treat

Tyrosine for low catecholamine symptoms

Tyrosine is the amino acid that boosts catecholamines and helps with focus, motivation, energy (especially when you crave carbs for energy) and the blah kind of depression. It’s wonderful for helping you easily quit coffee/caffeine (when you are using it to “self-medicate” due to low catecholamines). It also provides support for the thyroid.

Here are the low catecholamine symptoms I have my clients rate if they are considering a trial of the amino acid tyrosine:

  • Depression and apathy
  • Easily bored
  • Lack of energy
  • Lack of focus
  • Lack of drive and low motivation
  • Attention deficit disorder
  • Procrastination and indecisiveness
  • Craving carbs, alcohol, caffeine, or drugs for energy

DLPA for both low endorphin and low catecholamine symptoms

If someone has both low endorphin and low catecholamine symptoms, a trial of DLPA could be considered.  DLPA supports both endorphins (to a lesser extent than DPA alone) and also catecholamines (to a lesser extent than tyrosine used alone). You could think of it as doing half and half of each.

Low endorphin symptoms:

  • Heightened sensitivity to emotional pain
  • Heightened sensitivity to physical pain
  • Crying or tearing up easily
  • Eating to soothe your mood, or comfort eating
  • Really, really loving certain foods, behaviors, drugs, or alcohol
  • Craving a reward or numbing treat

And low catecholamine symptoms:

  • Depression and apathy
  • Easily bored
  • Lack of energy
  • Lack of focus
  • Lack of drive and low motivation
  • Attention deficit disorder
  • Procrastination and indecisiveness
  • Craving carbs, alcohol, caffeine, or drugs for energy

Why I prefer my clients use DPA and tyrosine, rather than DLPA

Many people do well with DLPA (you can read one example below) but over the years I have streamlined my amino acid recommendations and seldom suggest DLPA. Here are the reasons why I prefer DPA:

  • DPA is not stimulating and doesn’t affect sleep. However, DLPA can be stimulating for anxious folks (and the majority of my clients have anxiety). For this reason, DLPA can not be used later than 3pm as it can affect sleep and for some folks with really bad sleep issues it can’t be tolerated later than mid-morning (in a similar way to tyrosine).
  • I like to have clients use DPA alone so we can clearly identify the benefits they are experiencing for their low endorphin symptoms and then use tyrosine alone so we can clearly identify their low catecholamine benefits.
  • There are no precautions or contraindications with DPA. However, DLPA has the same precautions as tyrosine. This limits using it for endorphin support. These are the precautions:
    • Overactive thyroid/Grave’s disease: tyrosine, DLPA (avoid)
    • Phenylketonuria (PKU): tyrosine, DLPA (avoid)
    • Melanoma: tyrosine, DLPA (avoid)
    • High Blood pressure: tyrosine, DLPA (watch)
    • Migraine headaches: tyrosine, DLPA (watch)
    • Bipolar disorder: tyrosine, DLPA, glutamine (watch)
  • The women I work with who do have low endorphin symptoms have reported superior benefits from DPA compared to DLPA, especially for emotional pain and emotional eating.
  • Some folks can’t tolerate tyrosine and these same folks have a hard time with DLPA.

The one disadvantage with DPA is that it’s not as widely and readily available as DLPA. It often needs to be purchased online (I list some brands below).

Here is some feedback from folks to give you an idea how these amino acids have helped them.

As you’ll see, there are some individuals who do well with DLPA so it’s really a matter of looking at the symptoms and doing a trial.

DPA helps Missy with weepiness and a deep heart-ache (and tastes like dark chocolate)

Missy shares how DPA helped her deep heart-ache sort of feeling:

I have found I was using this product incorrectly. If you are feeling fine, you do not feel much of anything from it. But today I was weepy and felt that deep, heart-ache sort of feeling. I chewed 1000 mgs (2 capsules) and it DID help lift that awful feeling within 15 minutes.

Notice that she said if you’re feeling fine you don’t feel much at all. This is true of all the amino acids – they only make a difference when you need them.

Missy said that she chewed the capsule, however around 2019, the gelatin capsule was replaced with a cellulose capsule. It’s much more palatable when it’s opened up into the mouth. I blog more about opening the capsule here.

She also reported what about half my clients say:

Tastes like slightly bitter dark chocolate 🙂

The remainder of my clients don’t like the taste at all, although many say the taste grows on them. I’ve always been in the dark chocolate camp and find it quite pleasant tasting.

DLPA helps Toby with energy and pain relief (he has CFS and fibromyalgia)

Toby has a diagnosis of CFS (chronic fatigue syndrome) and fibromyalgia and shared how DLPA helps him:

I’ve played around with (I think) all variations of these aminos and have found unequivocally (in the sense of definite and fast observable changes as opposed to none) that DLPA is the one that works for me. I have wondered what that means. I am male, 45, diagnosed with CFS and fibromyalgia and have speculated that in lay terms the DLPA gives me a bit of energy and pain relief (endorphins). Is that a logical conclusion?

He posted an image of the DLPA product he used and said this:

After putting it on my tongue, very quickly I get an agreeable boost in energy and pain relief. I have not experienced this with DPA or tyrosine.

Based on what I’ve covered above with the symptoms you can see that Toby has made a very logical conclusion. He is getting both endorphin support (the pain relief) and catecholamine support (the energy).

Resources if you are new to using DPA or DLPA as supplements

If you are new to using the amino acids DPA or DLPA as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see the low endorphin and low catecholamine symptoms.)

If you suspect low levels of endorphins and/or low levels of catecholamine and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the team you or your loved one is working with. Blog posts like this are intended to add value to the chapter on amino acids, which contains detailed information on doses and time of the day for dosing.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the DPA and DLPA products that I use with my individual clients and those in my group programs.

For DPA I have used the Lidtke Endorphigen product for years and it’s a firm favorite with my clients (and I’ve used it myself).

I recently purchased  a bottle of Doctor’s Best D-Phenylalanine to test and it works just as well as the Lidtke product.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. It’s an opportunity to interact with me and other practitioners who are also using the amino acids.

Do you have any of the low endorphin and/or low catecholamine symptoms and have you seen benefit with DPA, DLPA and/or tyrosine?  If yes, please share what benefits.

Has this blog provided clarification on DPA vs DLPA, and will you be changing how you use these amino acids going forward?

If you’re a practitioner please share what you use with clients/patients.

Feel free to ask your questions here too.

Filed Under: Amino Acids, Emotional Eating, Pain, Women's health Tagged With: amino acids, anxiety, anxious, catecholamines, cfs, comfort eating, d-phenylalanine, Dark chocolate, dl-phenylalanine, DLPA, DPA, emotional support, endorphins, energy, Fibromyalgia, focus, heart-ache, hug, insomnia, motivation, neurotransmitters, pain, symptoms, tyrosine, weepiness, What is the difference between DPA and DLPA

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