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Archives for August 2018

Tyrosine for alleviating anxiety and panic attacks and creating a feeling of calm focus

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If you had anxiety, felt hugely stressed and were having panic attacks would you consider using tyrosine to help calm you? It’s not the first approach I use with a client as I typically want to calm things down first by addressing the low serotonin symptoms of anxiety (such as worry, overwhelm, insomnia and panic attacks) and the low GABA physical symptoms of anxiety (physical tension, stiff and tense muscles, overwhelm and panic attacks).

However, for some individuals addressing low catecholamines with tyrosine is the best approach to take, even if it feels counter-intuitive. Since everyone is different using the trial method is the best way to figure out what you need.

Here is another success story from someone using tyrosine, as shared in the comments on a recent blog post on tyrosine:

Tyrosine for anxiety has done wonders for me! I have tried GABA and Tryptophan. The GABA seemed to take the edge off a little when panic attacks occurred but wasn’t keeping anxiety from occurring.

I have been under tremendous pressure at work. The internal stress has been overwhelming! I haven’t been able to remember anything, even things I’ve done for years! I am in the process of learning new software at work. In the very first class my mind just went blank. The more I tried to focus the more stressed I became. All I could do was sit and stare at my screen while the rest of the class moved forward.

In short order I developed a migraine and panic. The internal pressure felt as if someone was wringing out my brain like one would do to a wash rag! I had to leave the class earlier. From this point on I was struggling to even do my job as I have done the last few years. Every time I tried to think I’d immediately become overwhelmed and shut down. I felt like crying most of the time from the sheer force of the internal pressure (this is embarrassing to admit as I’m someone with a competitive career). This stress just completely shut down my ability to learn and problem solve.

So, I decided to start some tyrosine. I was hesitant because I have heard it can cause panic attacks and I definitely don’t need more of those! I bought some powder and took 400mg on an empty stomach about 30 minutes before breakfast. WOW!!! Within an hour the stress just melted away!

I wasn’t stressed on my way to work either which normally I am. I was able to sit down and think thru my problems without feeling overwhelmed at all. Also, I was communicating with people much more easily. I noticed better eye-contact. I seemed less concerned of anyone’s opinions too.

I take another 400mg 30 minutes before lunch. I simply cannot believe how much better I am doing!

Just a few weeks prior I was telling my wife that I may need to start thinking about starting the process for disability because I simply could not function well enough to do my job.

I’d also add that the stress from the anxiety was so bad I felt like I had the flu for a few weeks. This also has dissipated since starting the tyrosine.

It’s still early in this experiment but I am hopeful for once. Nothing, and I mean NOTHING has worked so well so fast for me than tyrosine. It’s the closest thing to a miracle I’ve ever experienced. A night and day experience!

What wonderful results! I’m thrilled to hear about his “miracle” and that he’s doing so much better, that he has hope and that the stress from the anxiety has dissipated!

What approach to follow if you can relate to this situation

Of course, I thanked him for sharing his success story with tyrosine and added my response for other blog readers who may relate to this situation and may consider a trial of tyrosine as a first step when anxiety is an issue.

I still stand by my advice to start with GABA and tryptophan when you have anxiety whether it’s the low serotonin-type anxiety (worry in the head) or the low GABA-type anxiety (physical anxiety). I always have clients start by addressing these deficiencies first before adding tyrosine for the low catecholamine symptoms because tyrosine is too stimulating for many and can increase anxiety and insomnia (and may also cause a panic attack).

With the majority of the anxious clients that I’ve worked with, the order of doing trials is as follows: tryptophan or GABA first and then tyrosine.

Addressing his low catecholamine symptoms was what he needed

For this gentleman, clearly GABA and tryptophan support was not what he needed or was not enough to ease his anxiety. Addressing his low catecholamine symptoms was what he needed to do.

In case you’re wondering how he’s doing now – I reached out to him and he reports he’s still taking tyrosine and is still doing great!

He is the third person that I know of who has experienced these types of results with tyrosine so I expect there are others who could benefit too – which is why I decided to share his story.

Increased anxiety because of lack of focus and low motivation

Here is another similar story from a prior client of mine. She had terrible anxiety, and we trialed both GABA and tryptophan. While she did get some benefits with both it just wasn’t enough.

She was sleeping better but still felt so stressed and anxious when preparing for an important meeting at work which she was in charge of running. The anxiety also seemed to get worse during the meetings. She did also score high on the low catecholamines section on the amino acid questionnaire (poor focus, low motivation, fatigue, ADHD, depression) but were working on the low serotonin and low GABA types of anxiety before addressing poor focus and low motivation.

It turned out that her anxiety escalated around her work meetings because of her lack of focus and low motivation – she was pushing herself to get through them. Once she added tyrosine her anxiety was under control. In this instance tyrosine actually helped ease the anxiety because her ADHD symptoms diminished and her motivation and drive improved!

This is what biochemically individuality is all about and how we all have our own unique needs. And is why I love the trial-method for determining which amino acid is best for your own unique needs.

Here are some related blog posts that you may find helpful:

Do let us know if you have experienced less anxiety and a sense of calm focus when taking tyrosine?

Radical Metabolism: boosting energy, enhancing digestion, improving hormone health and blasting fat

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Ann Louise Gittleman has a new book called “Radical Metabolism: A Powerful New Plan to Blast Fat and Reignite Your Energy in Just 21 Days.”

Last week I had the wonderful opportunity to interview her! The book is primarily about weight-loss but I chose to focus on other aspects in our interview. We talked about so many valuable topics for boosting metabolism and energy, enhancing digestion, improving hormone health and reducing anxiety.

She shares that no disease can be healed if your cell membranes – which direct nutrients in and poisons out – are weak and unstable:

Radical Metabolism is all about what to eat to rebuild and fortify those lipid (fat)-based cell membranes, so that toxins are prevented from moving up the chain and gunking up the function of every cell, tissue, and organ in your body, from your brain to your thyroid, gallbladder, liver, kidneys, and skin. This is where omega-6 fats really shine.

Here are some of the highlights of what we covered, together with some related snippets from the book:

– our gallbladders and thyroid health

a study out of Finland found that people with decreased bile production are nearly ten times more apt to experience hypothyroidism. With low thyroid on the rise, this provides great hope to the millions of hypothyroid sufferers who experience metabolic slowdown as well as fatigue, dry skin, and constipation. Besides hypothyroidism, studies have also connected poor quality bile with chronic fatigue, migraines, depression, and autoimmune disorders.

– the importance of bile for digesting fat and absorbing fat-soluble vitamins

Bile is stored in the gallbladder to break down dietary fat and remove toxins from the body. Harvard Medical School research has revealed that subjects with improved bile health showed a remarkable spike in metabolism.

– the metabolic benefits of omega-6 fats – hemp seed oil, sesame seed oil, pine nut oil and ghee

Hemp seeds are one of nature’s greatest gifts, perfect little bundles of benefits for your entire body. You can reap the hemp’s benefits by consuming the oil, seeds (typically these are “hemp hearts” which have had their hulls removed), or by blending them into hemp milk. Hemp seeds are about one third healthful fats and one quarter protein, as well as a magnificent source of natural GLA (gamma-linolenic acid). It’s hard to find a food with a better essential fat profile – hemp boasts a 3:1 omega-6–to–omega-3 ratio.

– omega-6s and pyroluria/zinc absorption (my addition)

– why to include these oils if you’re eating a keto or paleo diet

– why bitters are beautiful – the big one is improving digestion and stimulating bile production!

Studies suggest bitters “get your juices flowing” (literally) by stimulating the release of bile, as well as saliva, HCl, pepsin, gastrin, and pancreatic enzymes.

– watercress as a great bitter food bile booster

Watercress is kind of the forgotten stepchild of the cruciferous family – a peppery-flavored cousin to cabbage, arugula, and mustard greens. Recent studies have put watercress back on the menu thanks to its powerful health-stimulating benefits, which is why it deserves a starring role in the Radical Metabolism plan

Besides being a bitter food bile-booster, in a study led by nutritionist Sarah Schenker a small group of women lost an average of 17 pounds in six weeks on a watercress soup diet. The exceptional antioxidants in watercress pump up your energy while exercising, while at the same time protecting you from exertion-related DNA damage. According to head researcher Dr. Mark Fogarty, watercress contains ten times as many beneficial chemicals as any other fruit or vegetable.

– how coffee and cacao work as bitters and dandelion tea as a good alternative (also bitter) if you can’t tolerate coffee

– and grapefruit as a bitter fruit (and one of the reasons why the grapefruit diet worked!)

– why testing ferritin is so important (and why to avoid cast iron pots)

Here is the audio of our interview. Enjoy!

And here is the recipe for: Creamy Dreamy Watercress Soup

This soup is not only fat-burning, but filling and flavorful. The recipe makes about one day’s worth of soup on the 4-Day Radical Intensive. You can either prepare it daily or cook up four batches in advance—whatever works best with your schedule.

Makes 6 cups

4 cups bone broth, either homemade (page 216) or Kettle & Fire

1/2 large bulb celeriac (celery root), (about one 5-inch bulb), brown exterior removed (do not to remove too much); cauliflower works as substitute

1 bunch leeks, cleaned and sliced

1 daikon radish, roughly chopped

1 (2-inch) piece fresh ginger, peeled and chopped

1 to 2 teaspoons sea salt, to taste

1 Radical Lemon Cube

1 large bunch watercress, roughly chopped

Optional: Add 1/2 to 1 teaspoon miso to each warm bowl of soup

Bring the broth to a simmer in a saucepan. Add the celeriac, leeks, daikon, and ginger. Add enough water to the pot to just submerge the vegetables. Simmer for 20 minutes, or until the veggies are tender.

Using an immersion blender, blend the soup until creamy. If too thick, you can always add a bit more water. Stir in the salt, lemon cube, and watercress. Simmer for 5 minutes, then blend again with your immersion blender.

Serve in a mug or bowl with or without the miso.

Note: To make Radical Lemon Cubes: 3 lemons quartered, 1 cup filtered water

Place the lemons and water in a blender or food processor and puree. Spoon the puree into ice cube trays and freeze.

Ann Louise Gittleman, New York Times bestselling author of more than thirty books including The Fat Flush Plan series and Before the Change, has been revolutionizing the rules of health and nutrition for more than three decades. She holds an MS in Nutrition Education from Columbia University, the title of Certified Nutrition Specialist (CNS) from the American College of Nutrition, and a PhD in Holistic Nutrition. Gittleman has also served as the Chief Nutritionist of the Pediatric Clinic at Bellevue Hospital and is the former Director of Nutrition at the Pritikin Longevity Center in Santa Monica, CA. She currently sits on the Advisory Board for the International Institute for Building-Biology & Ecology, the Nutritional Therapy Association, Inc. and Clear Passage, Inc. Read more about her at www.annlouise.com.

Grab your copy of Radical Metabolism on Amazon here (my Amazon link). Grab bonus ebooks and details about the private Facebook group here

Enjoy! And do let us know what you think of these tips and the watercress soup recipe. And be sure to leave a review for Ann Louise.

WiFi modem with a public hotspot causes seizures, vertigo, headaches, insomnia and heart palpitations in a woman with a history of West Nile virus

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This recent research illustrates the harmful effects of a new type of wireless modem, enabled for both personal use and functioning as a public hotspot: Exacerbation of demyelinating syndrome after exposure to wireless modem with public hotspot. The public hotspot feature was designed to reach up to 100 meters (or 328 feet which is close to the length of a football field).

Here is the entire abstract since it explains the situation so well:

In August 2003, 48-year-old JS of Colorado, USA, a fitness therapist and sports nutritionist, contracted neuroinvasive [i.e infecting the nervous system] West Nile virus which left her with disabilities due to spinal axonal damage.

In August 2014, she suddenly developed symptoms very much like her acute West Nile infection 11 years ago, including focal seizures, ataxia, vertigo and headaches. Her blood count looked normal so there was no obvious infection. What struck her as odd was that when she left her apartment for any length of time, the symptoms stopped.

She found out that a new type of wireless modem, enabled for both personal use and functioning as a public hotspot designed to reach up to 100 m, had been installed in the flat under hers. Her neighbor replaced the modem with a router without the hotspot feature. After that, the seizures stopped immediately, and the other symptoms faded gradually, after which she was fine and again could sleep well.

Later, when another activated hotspot was installed in an adjacent flat, JS once again noticed symptoms.

A possible association between electrohypersensitivity, myelin integrity and exposure to low-intensity radiofrequency electromagnetic fields (RF-EMF) typical in the modern world has recently been proposed.

Since the West Nile virus attacks both the nerve cells and the glial ones, one explanation to the above observed case effects is that the initial virus attack and the wireless modem’s RF-EMF affect the nervous system through the very same, or similar, avenues, and maybe both via the oligodendrocytes [i.e. the myelinating cells of the central nervous system].

Here are a few of the other symptoms she reported before discovering that it was the public hotspot that was causing her symptoms:

  • losing sensation in her face, neck and torso
  • tinnitus (ringing in the ears)
  • allergy symptoms like those of severe hayfever
  • difficulty concentrating
  • poor fine motor control
  • impaired short-term memory
  • pain in the facial bones, especially the cheeks, jaw bones and the roots of her teeth
  • numbness and tingling
  • difficulty breathing and swallowing (more pronounced after exertion)
  • dizziness
  • elevated morning fasting blood sugar levels (up 25% from usual to 100 mg/dL) and then back to normal 2 weeks after the hotspot was disabled
  • fight or flight reaction for the first 2–3 weeks, which then turned into fatigue and apathy with little accomplished during the day

These symptoms all dissipated when she wasn’t home. Once home in the evenings, her desire for sweets increased and her sleep was also impacted:

In the evening, her appetite was much increased and she craved sweet food, which was not usual for her. She became sleepy at the usual time, settling down between 10.30 pm and 11 pm and could fall asleep, all as normal.

However, within 1–2 hours, she routinely woke suddenly having had very vivid, disturbing dreams and with a pounding heartbeat. This was usually followed by a seizure, sometimes focal, where one part of her body (primarily right arm) would be shaking. Other times, her whole body was shaking.

She also noticed more severe symptoms when the modem with the activated public hotspot was closer to where she slept i.e. distance was a factor. On bad nights, after waking, she would sometimes go and sleep in her living room which was further away from the modem.

After a seizure, she slept fitfully, unless she moved to sleep on the couch in another room. There, JS found she could fall asleep quite quickly and sleep through the rest of the night.

When in her bedroom the modem was just 20–30 feet away and when in the living room it was about 50–60 feet from her (plus an additional wall), both of which weakened the signal.

It should also be noted that JS used a cell phone, a wireless router and a computer and had no problems from any of these – it was only the modem with the public hotspot that was problematic.The study authors shared that

The hotspot antenna almost certainly has a considerably higher transmit power as this would be needed to increase the effective transmit range for users in the area.

Other possible causes/mechanisms are reported as follows:

  • the pulse width of the beacon signal
  • an additional pattern or stroboscopic effect, or double intensity set up by the simultaneous transmission of the private and public hotspots

However, do keep in mind that for some people with electrohypersensitivity, simply using a cell phone and WiFi can cause symptoms.

Do you know if your router has this public Wi-Fi hotspot feature turned on?

Do you know if your router has this public Wi-Fi hotspot feature turned on? Many people do not and are fuming when they find out – I know I was!

JS discovered this as a result of a pop-upon her mobile phone:

From before the episodes occurred, JS kept her mobile phone WiFi disabled while at home. The day after she began having symptoms in August, she had temporarily enabled the WiFi feature while out shopping and when she came home that day, a pop-up appeared informing her she was in a free Xfinity WiFi zone.

In this article two Comcast customers sued the company for turning their Xfinity Internet routers into public WiFi hotspots saying “Comcast’s actions pose risks to subscribers and are taken without seeking their authorization.” They objected to the increase in customers’ electricity costs, the impacts on network performance and network security concerns.

However, they don’t even raise the issue of potential harm from a public WiFi hotspot that is activated on a modem in your home or one nearby.

In fact this site that offers instructions for disabling this public WiFi hotspot on your Comcast Xfinity router states that “We don’t necessarily think you have to disable this feature, as it seems to work fine — we haven’t heard any horror stories or reports of problems yet.”  

I would consider this case study to be a horror story that is not common knowledge and needs to be. JS was seriously harmed on two occasions by modems with public WiFi hotspots. In both instances the home-owners with these modems were not even aware they had these public hotspots activated and very quickly had them disabled once they found out what was happening to JS.

The study authors conclude that this case study strongly indicates that:

emissions from these new wireless modems could cause physical harm for those susceptible to that type of radiation.

My questions are this:

  • How many people are not even aware that their modem has this public WiFi hotspot feature enabled?
  • How many other people like JS are being seriously harmed by modems with public WiFi hotspots?
  • How many people have chronic issues like problems falling asleep, waking in the early hours, agitation, anxiety and heart palpitations – all possibly caused by a public WiFi hotspot on their modem or on a modem next door or even down the street?

I consider JS to be the canary in the coal-mine and her story is a good lesson for all us to wake up and get serious about WiFi and EMFs.

Here are some other blogs posts I’ve written about WiFi and EMFs:

Do share what you’ve experienced with modems that have public WiFi hotspots activated and if you can relate to any of the symptoms JS experienced?

Lyme Disease: An Overlooked Underlying Cause of IBS & SIBO

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Lyme disease is an overlooked underlying cause of IBS & SIBO and Dr. Tom Messinger addresses this fascinating connection in his interview on the IBS & SIBO SOS Summit, happening September 3-10, 2018.

Summit host, Shivan Sarna, found out about this connection when she told Dr. Messinger that her feet really hurt. He responded with this:

You know, the spirochetes from Lyme do like the feet

Who knew!?

He also shared that an acute presentation of Lyme disease can manifest with GI symptoms such as nausea, vomiting, diarrhea:

a common underlying cause of SIBO is what’s considered either a GI flu or food poisoning. Most times, clinically, you can’t tease out which of those two scenarios happened. The person just has the same symptoms—nausea, vomiting, diarrhea, abdominal cramping.

However, there is research—and that’s published research—showing that one of the ways an acute presentation of Lyme disease can manifest is that those GI symptoms—nausea, vomiting, diarrhea.

So, a person that has that, and then years down the road is diagnosed with SIBO, it’s traced back to that as probably the onset, and thinking, “Well, it’s probably a GI flu,” you don’t get worked up for it, or it was a food poisoning, but it could’ve actually been a tick bite, Lyme disease, that caused that. And it was written off as it was just a GI flu. So an acute presentation, Borrelia can cause those symptoms that may lead down the road to SIBO.

And there is more:

  • We know that Borrelia does live in the intestinal lining cells
  • Borrelia has an affinity for nervous system tissue and that’s why there’s a lot of neurological symptoms in Lyme. But as we know, the GI system has a lot of nervous system tissue in it. It’s felt that Borrelia has an impact on the migrating motor complex and definitely has a profound impact on motility. It could either make motility hyperactive or hypoactive (diarrhea or constipation).
  • Borrelia has a great affinity for that and usually will impact the vagus nerve. The vagus nerve is your main parasympathetic nerve in your body that helps to regulate all of your digestive function—hydrochloric acid secretion, pancreatic enzyme secretion, motility.

He reminds us to not discount the possibility of Lyme disease based on the following belief:

Well, I don’t live in the northeast. I don’t hike. I’ve never had a tick bite with a bulls eye rash. So there’s no way I could have Lyme disease

Dr. Messinger goes on to talk about the incidence of Lyme, how it can be transmitted, how it affects many body systems (digestion, neurological, hormones etc.), the challenges with Lyme testing, treatment and how overall toxicity may be playing a role in symptom severity.

I have chronic SIBO myself and I’m a speaker on the summit too. I cover how GABA reduces the visceral pain of IBS & SIBO, eases anxiety and helps with insomnia, plus some other protocols for easing the pain when the dreaded belly bloat occurs and you can’t sleep.

I’m also in the process of testing for Lyme disease. I wonder if this is one of the underlying causes of my SIBO? You’ll be sure to hear from me once I find out more.

Summit host, Shivan, asks the excellent questions YOU would ask if you were in the room with these experts. She draws on her own experience with painful digestive issues and years of failed treatments (alternative and conventional) to be YOUR champion for improved health…

…and she’s here to share her knowledge with you!

Join us at The IBS & SIBO SOS Summit to learn more about:

  • Identifying the root cause of your digestive struggles
  • Saving money from wasted doctor visits and ineffective treatments
  • Identifying which foods cause your flares
  • Naturopathic and conventional principles important to gut healing
  • Strategies for food reintroduction
  • Treatments, protocols and diets for IBS and/or SIBO
  • And more!

The IBS & SIBO SOS Summit is online and complimentary from September 3-10, 2018!

I’ll see you online at this educational summit when you register here today

GABA reduces the visceral pain of IBS & SIBO, eases anxiety and helps with insomnia

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I have chronic SIBO (small intestinal bacterial overgrowth) and shared some insights – during an interview on the IBS & SIBO SOS Summit – on what helps me when I’m trying a new protocol or new food and get that awful and painful belly bloat.

It’s so bad that I’m in pain all night, tossing and turning and can’t sleep…. and Iberogast, enzymes and peppermint and lavender essential oil on my bloated belly help so much:

Because of the cellulose in one of the Candibactin products, I was getting the bloating. And the Iberogast taken at night just before I went to bed (together with a few other things) definitely helped with some of the bloating.

For me, the problem with the bloating is the pain (obviously), but worse than that is the lack of sleep. If I’m bloated, it just feels like I’m tossing and turning the whole night. And if I don’t get eight hours of sleep, I’m a mess. So, the biggest issue for me is the impact on my sleep.

But if I’ve got this huge, bloated belly which was happening a lot, I take enzymes that help with carb digestion. I will also rub peppermint essential oil on my belly. So I’ve got a little bowl of coconut oil with a dab of lavender (it’s calming and it helps you sleep as well) and a little bit of peppermint oil.

There’s a number of studies showing that essential oil or peppermint ingested in a capsule can help with IBS. And I’ve found that, topically, it can help too. So that works for me to help with some of the bloating.

I also share about my 2 favorite amino acids – you guessed it – GABA and tryptophan. They just have so many applications! In this instance of painful belly bloating they help with pain and sleep and improve motility:

The other thing that helps is GABA which is one of the amino acids. There is research discussing the role of GABA in stress-induced visceral hypersensitivity. GABA helps with reducing the visceral pain that is seen with IBS/SIBO because we have GABA receptors in various parts of the body, including the digestive system. GABA is amazing for physical tension/anxiety and it can ease that. I’m thinking that this easing of physical tension may be one of the mechanisms as to how it works for some of the pain issues.

I do want to mention something about GABA – it works most effectively when taken sublingually. I just chew a capsule and get the results. And it works within five minutes.

And then, the other one that I use at night is tryptophan. This really helps with the sleep as well by boosting serotonin levels. It actually helps with motility too – there’s research showing this.

If your SIBO causes increased anxiety, these two amino acids would help ease those symptoms too – GABA for the physical anxiety and tryptophan for the worry in the head anxiety:

And then, it helps with anxiety as well if that’s an issue – for many people with IBS and SIBO, anxiety is an issue.

Summit host, Shivan Sarna, shares how LDN (low dose naltrexone) has helped her tremendously (she also has chronic SIBO) and we discuss how too much can increase anxiety and impact your sleep. Since doing this interview I’ve had feedback from two people who successfully used GABA Calm to reduce their anxiety from too high a dose of LDN.

We also touch on some of the possible mechanisms of LDN, I share some of the benefits of berberine, and we discuss benzodiazepines which are so often prescribed for IBS/SIBO (for the anxiety, the insomnia and the pain) and why nutritional approaches are a safer option.

Have topical peppermint/lavender essential oils helped with belly bloat?

Has GABA or tryptophan helped you with the pain, poor motility or anxiety associated with SIBO?

Feel free to post your feedback and questions in the comments below.

Why is vitamin B6 toxic for some and why don’t symptoms resolve when vitamin B6 is stopped?

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In a recent blog post, Vitamin B6 improves dream recall (which can be used to monitor vitamin B6 status), I promised to address concerns about the potential for vitamin B6 toxicity. I have yet to see any signs of toxicity in my clients, but I have also not ever recommended more than 500mg/day.

However, I was recently made aware (thanks to some folks in my community) that there are some individuals who have issues with very small amounts of vitamin B6.  As of this writing I don’t know why this occurs but I’m writing about it in the hope we can start to put some of the puzzle pieces together. If you have experienced any issues with using vitamin B6 supplements please do share in the comments.

I’d like to start with what we know from the research and from experts like Dr. Carl Pfeiffer – since B6 is water soluble, excesses are documented to be excreted via the urine so that toxic levels are never reached.

It is common knowledge that amounts of 50 mg or greater are considered therapeutic and a high dose, and you should reduce your dose if you notice any tingling in your fingers and other extremities. This could be a sign of too much vitamin B6 and is called peripheral neuropathy. Because vitamin B6 is water soluble, this condition is reported to be completely reversible if you stop supplementing with vitamin B6 or reduce your dose. In one case report, some patients were using up to 5000mg/day, and once they stopped the vitamin B6 their symptoms improved.

In his book Mental and Elemental Nutrients, published in 1975, Dr. Pfeiffer stated:

excesses are excreted via the urine so that toxic levels are never reached. Pyridoxic acid occurs in the urine of patients who take any excess of vitamin B6. This is a harmless excretion product.

He had some of his patients with pyroluria use 1000mg twice a day but recommended working with a practitioner if using amounts higher than 500mg. I agree with the latter.

You’ll see varied research papers on what is considered too high a dose. In this paper, How much vitamin B6 is toxic?, the authors report that 1000mg per day or more causes neuropathy. They also share that there

have also been occasional reports of toxicity at intakes of 100-300 mg per day [and that a report of] neurotoxicity in 2 patients who had taken 24 mg and 40 mg of vitamin B6 per day respectively, may be coincidence rather than a true toxic effect of such relatively low doses.

In the USA, per this article on the NIH site, the upper limit is set at 100mg/day. This is the rationale:

several reports show sensory neuropathy occurring at doses lower than 500 mg/day, studies in patients treated with vitamin B6 (average dose of 200 mg/day) for up to 5 years found no evidence of [neurological issues].

Based on limitations in the data on potential harms from long-term use, the FNB halved the dose used in these studies to establish a UL [upper limit] of 100 mg/day for adults. ULs are lower for children and adolescents based on body size.

As I mentioned above, I have yet to see any signs of toxicity in my clients, but I have also not ever recommended more than 500mg/day.

Psychosis that resolves when vitamin B6 is stopped

A colleague shared this about 2 patients developing psychosis as a result of using too much vitamin B6:

I have had 2 patients in the past 3 years who developed psychosis as a result of taking too much vitamin B6. I think it’s a fine line between what is enough for some people, and then what becomes too much. While some may be able to handle large doses of B6, we know that at higher doses it can cause severe problems for other people. It’s a nutrient I dose and monitor carefully for sure.

There is no research on acute psychosis and vitamin B6 toxicity but she shares this:

neuropathy and psychosis (or acute mental health symptoms) often co-occur, so to me it makes sense that a person could experience both together as a result of too much vitamin B6. In both the patients the acute psychotic symptoms resolved once they stopped taking high doses of B6. They were both taking pyridoxine HCL at doses above 500mg daily (one because of information she had read online, and the other because another practitioner had recommended it). My guess is there is some genetic factor and/or mediating factor biologically that makes some people susceptible to a negative response.

Serious issues that are not resolved when vitamin B6 is stopped

Clearly there are some individuals who do have serious issues that are not resolved when they stop taking vitamin B6. In the previous blog, Vitamin B6 improves dream recall (which can be used to monitor vitamin B6 status), Ruth shared this feedback about her experience with vitamin B6 toxicity:

Trudy, I appreciate your evidence-based approach to health issues, but I think you need to be aware that there are dangers in taking too much synthetic vitamin B6. B6 toxicity is not always reversible. Individuals vary in their response to B6, and while many do well on supplementation, others experience toxicity. I was diagnosed with pyroluria, but experienced serious toxicity.

Vitamin B6 toxicity is a very unrecognized but emerging epidemic that can cause widespread neurological damage to the body. It is not commonly recognized by most of the medical community and is often misdiagnosed. B6 toxicity can cause multiple different symptoms that can vary from person to person. Peripheral neuropathy or nerve damage to the feet, legs or hands is one of the most common symptoms of vitamin B6 toxicity. Tingling, shocks/zaps, vibrations, ataxia, burning, numbness of feet, calves and/or hands, and headaches are also commonly reported. Other symptoms are: ocular, sensory, skin, gastrointestinal and psychological.

I appreciate Ruth sharing this and am very concerned that this is happening. And yes, vitamin B6 is synthetic, but I am not yet convinced that this could be the only cause as there are other synthetic/man-made supplements (such as GABA) that don’t cause issues like this.

However, we do need to know why some folks have issues and why these issues continue even when the vitamin B6 supplementation is stopped.

Possible clues as to why vitamin B6 toxicity occurs?

If you have had issues that persist I’d ask these questions which may start to give us clues as to why this occurs:

  • What were/are your symptoms and how quickly did you notice issues?
  • Have you resolved the symptoms and if yes how?
  • Did you make any other changes around the same time i.e. stopping and/or other nutritional support?
  • Was it vitamin B6/pyridoxine or P5P you were taking?
  • And how much did you take and how often?
  • If you have pyroluria were you also taking zinc and how much? (Dr. Pfeiffer recommended taking zinc together with vitamin B6).

It seems like this an emerging issue unless there is just now more awareness because of the web and more ability to share on forums, blogs and social media.

If we are to assume this is a new and emerging issue I would ask what has changed since the 1970s when Dr. Carl Pfeiffer used high doses (as I mentioned above, up to 1000mg twice a day) with no adverse effects?

These factors have wide-reaching adverse effects and may be triggering a toxic reaction in certain susceptible individuals:

  • Past history or current use of certain medications like benzodiazepines, gabapentin, Lyrica, BCP, SSRIs, fluroquinolone antibiotics, PPIs, diabetes medications, statins, blood pressure medications etc.? (If you have not used the above medications have you been exposed to them via drinking water?)
  • Our increased EMF exposure – WiFi, cell phones, cordless phone and smart meters?
  • Our increased exposure to GMOs, glyphosate, plastics/phthalates, pesticides etc.?
  • Interactions with all of the above and/or certain polymorphisms – we know cytochrome P450 polymorphisms make benzodiazepines more toxic and more difficult to taper in about 60% of those prescribed benzodiazepines

Keep in mind that for most individuals, vitamin B6 causes no issues and is an important nutrient for improving the symptoms of pyroluria/social anxiety, reducing inflammation and oxidative stress, easing PMS and hormonal issues and much more. I share links to the research on the many benefits of supplemental vitamin B6 in this blog:  Vitamin B6 improves dream recall (which can be used to monitor vitamin B6 status).

That being said, we need to know why some individuals do have issues when using vitamin B6.

Please share in the comments if you have seen adverse issues with vitamin B6 supplementation

If you have been adversely affected and feel comfortable sharing answers to the following questions in the comments this may help us try and piece the puzzle together:

  1. What were/are your symptoms and how quickly did you notice issues?
  2. Have you resolved the symptoms and if yes how?
  3. Did you make any other changes around the same time i.e. stopping and/or other nutritional support?
  4. Was it vitamin B6/pyridoxine or P5P you were taking?
  5. And how much did you take and how often?
  6. If you have pyroluria were you also taking zinc and how much? (Dr. Pfeiffer recommended taking zinc together with vitamin B6).
  7. Past history or current use of medications like benzodiazepines (such as Ativan, Xanax, valium etc.), gabapentin, Lyrica, BCP / birth control pill, SSRIs /antidepressants (such as Prozac, Celexa, Lexapro, Paxil, Zoloft etc.), fluroquinolone antibiotics (such as ciprofloxacin/Cipro, gemifloxacin/Factive, levofloxacin/Levaquin, moxifloxacin/Avelox, norfloxacin/Noroxin and ofloxacin/Floxin), PPIs (proton pump inhibitors such as Nexium for heart-burn), diabetes medications, statins, blood pressure medications etc.?
  8. What kind of EMF exposure do you have – WiFi in the home and/or at work, how much cell phone use in a day, cordless phones at home and/or work and a smart meter at home?
  9. What kind of  exposure have you had to GMOs and pesticides (i.e. do you only eat organic food), glyphosate (eg. Roundup exposure from lawns, golf courses, parks etc.), plastics/phthalates (do you avoid plastics)?
  10. What polymorphisms do you have: cytochrome P450 polymorphisms (we know some of these make benzodiazepines more toxic and more difficult to taper in about 60% of those prescribed these meds), and/or MTHFR polymorphism (may affect our detox ability if it’s expressing) and others you know about?
  11. Did you take a B complex (or a multivitamin that contains all the B vitamins) with the vitamin B6?
  12. Did you also take magnesium with the vitamin B6 and if yes how much? (Bernie Rimland reported that taking vitamin B6 together with magnesium resulted in an improved behavior of ASD (autism spectrum patients))
  13. Have you observed any correlation with intake of dietary oxalates i.e. worsening symptoms when consuming medium or high oxalate foods (such as spinach, kale, berries, nuts, kiwi fruit, eggplant etc.) or using vitamin C or milk thistle, and less severe symptoms when consuming a low oxalate diet?  (Susan Owens is founder of www.lowoxalate.info and shares that vitamin B6 is the most efficacious vitamin for reducing oxalates and that we also don’t know if the classic signs of vitamin B6 toxicity has anything to do with oxalate dumping symptoms.)
  14. Do you have a thyroid disease? “peripheral diseases frequently include polyneuropathy”
  15. Have you been diagnosed with an autoimmune condition and if yes, which one?

Is there anything else that you have discovered that you suspect may be a factor?

I plan to add to this list of questions as we get feedback and as I learn more.

To be clear, I’m not dismissing the fact that vitamin B6 toxicity is a real issue for certain individuals. I’m simply trying to figure out if there are some common factors that may be making symptoms worse in some individuals or setting someone up to be predisposed to symptoms or even preventing healing/recovery from toxicity.