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Fecal microbiota transplants and helminth therapy on the SIBO SOS Summit

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Mark Davis covers fecal microbiota transplants and helminth therapy on the SIBO SOS Summit part II. The title of his interview is: No Holds Bar Conversation About Fecal Transplants (yup, we go there) From a Fearless Expert. You will discover:

  • How Helminth therapy benefits autoimmune conditions & allergies
  • Fecal Matter/ microbiota Transplants: The shocking treatment with incredible results
  • New options for treating C Diff
  • Why not all parasites are bad! Parasite, commensal, and mutualistic organisms explained

This is what Mark has to share about helminths (microscopic worm-like organisms) and SIBO

My understanding of Dr. Pimentel’s hypothesis is that SIBO is really autoimmune enteritis. It’s your own body’s immune system launching antibodies either against cytolethal distending toxin B (CDT) or against vinculin in the gut. That’s an autoimmune process.

What these microscopic worm-like organisms, helminths, do for us is they invoke a robust T-regulatory cell response. T-regs are responsible for telling the rest of the immune system when to calm down.

If you’ve ever looked at the great book, Epidemic of Absence, the premise of the book is how absence of exposure to microbes, including helminths—your ancestors were exposed to them over and over again—absence to all that might be causing an epidemic of allergic and autoimmune disease today.

He also shares that his favorite helminth is one called Necator Americanus.

That’s the new world human hookworm. I have about 30 of them living in my gut right now. I’ve worked with dozens of patients using these.

Mark also shares what fecal microbiota transplantation is and how it is delivered:

taking the microorganisms that are alive in stool, which you have tens of trillions of them in and on you right now, and it is filtering and processing those in a way to isolate the important parts, as much as you can, and then delivering those to the gastrointestinal tract of somebody with a dysbiotic gut flora. That can be via capsule or upper endoscopy or via lower endoscopy or enema. Those are the most common ways to deliver it.

He goes on to share how effective a FMT is for a C. diff infection (when nothing else works, the FDA rulings about it only being allowed for C. diff or as part of a study, and how he is guiding his ulcerative colitis and Crohn’s disease patients through a DIY version.

I love this comment from Mark when we he is asked about the ick factor of working with poop:

It doesn’t feel like I’m processing poop. It feels like I’m mixing up a magic brew to help my patients.  

Here is some background on Mark Davis, ND: He practices at the IBD Specialty Center in Silver Spring, Maryland, and once per quarter at Bright Medicine Clinic in Portland, Oregon. He specializes in natural gastroenterology, especially the care of adults and children with inflammatory bowel disease. He is one of the few clinicians in North America with significant clinical experience using fecal microbiota transplantation (or FMT) as a therapeutic intervention, and has written and lectured extensively about FMT and helminthic therapy. He sits on the board of directors of the Fecal Transplant Foundation, and serves on the editorial board of the Natural Medicine Journal.

Mark is one of the speakers on the SIBO SOS Summit Part II. SIBO (Small Intestinal Bacterial Overgrowth) is a leading cause of IBS (irritable bowel syndrome). The most common SIBO symptoms are digestive issues, pain and bloating, and there are many other complications such as leaky gut and yeast overgrowth that make it difficult to diagnose and treat SIBO. Anxiety, depression and insomnia are common symptoms too.

FMT is not actually for used for treating small intestinal bacterial overgrowth (SIBO) and Mark shares this caution for about 5% of SIBO sufferers:

When you’re delivering [FMT] via capsules or upper endoscopy, some or all of them may end up in the small bowel. Ninety-five percent or more of the time, that ends up not being a problem, but if people already have impaired motility in the small bowel or an existing autoimmune process, or an existing small intestinal bacterial overgrowth (SIBO), that can compound the problem.

Part II of the SIBO SOS is all new interviews and is a great resource. Here are just a few of the guests and topics:

  • Dr. Allison Siebecker, Shivan Sarna, and Kristy Regan—Delicious Nutrient Rich Foods to Eat Even When You Have SIBO
  • Susanne Breen—When a SIBO Patient is Also a SIBO Doctor: The Obstacles and Strategies That Work For Her and Her Patients.
  • Dr. Megan Taylor: Been There, Done That! Help For Patients From a Doctor With Chronic SIBO
  • Dr. Norm Robillard—Choosing Diet Over Drugs
  • Angela Privin—How a Gut Health Coach Cured Herself of IBS After One Year of Paleo Done Right
  • Whitney Hayes—The Art and Science of SIBO Treatment
  • Jason Wysocki—The Importance of Neurology on GI Health and SIBO

You can register for the SIBO SOS Summit Part II here (it runs from Oct 21 to Oct 29)

Midday bright light therapy for bipolar depression

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A recent study from Northwestern University and published in The American Journal of Psychiatry: Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial has found that midday daily exposure to 7,000 lux bright white light for 6 weeks, significantly decreased symptoms of depression and increased functioning in people with bipolar disorder.

The press release issued by Northwestern University reports as follows

Previous studies found morning bright light therapy reduced symptoms of depression in patients with Seasonal Affective Disorder (SAD.). But patients with bipolar disorder can experience side effects such as mania or mixed symptoms from this type of depression treatment. This study implemented a novel midday light therapy intervention in an effort to provide relief for bipolar depression and avoid those side effects.

Compared to dim placebo light, study participants assigned to bright white light between noon and 2:30 p.m. for six weeks experienced a significantly higher remission rate (minimal depression and return to normal functioning). More than 68 percent of patients who received midday bright light achieved a normal level of mood, compared to 22.2 percent of patients who received the placebo light.

Images used with permission from Northwestern University

How the 7,000 lux bright light therapy was used

Here are the details of how the 7,000 lux bright light therapy was used in the study:

The light therapy patients were instructed to place the light box about one foot from their face for 15-minute sessions to start.

Every week, they increased their exposure to the light therapy by 15-minute increments until they reached a dose of 60 minutes per day or experienced a significant change in their mood.

Study lead author Dr. Dorothy Sit shares that starting low and slowly increasing the treatment made it more tolerable. None of the study participants experienced side effects, likely because the treatment was customized for each patient:

No one experienced mania or hypomania, a condition that includes a period of elation, euphoria, irritability, agitation, rapid speech, racing thoughts, a lack of focus and risk-taking behaviors.

A noticeable mood improvement with bright light therapy was also noticed as quickly as four weeks, which is similar to other light therapy research for non-seasonal depression and depression during pregnancy.

How do you do this in the middle of a work day?

You may have concerns about doing this at midday as this facebook follower voiced:

I guess if your bipolar depression is so debilitating that you cannot hold a job, then this is worth trying.

But 60 minutes!! What working person has 60 minutes in the middle of their workday?

It’s very doable because there are very nice desk versions that could easily be used at work (without anyone knowing – if privacy is a concern) or at a home-office desk for your convenience. I share some examples in this blog – Winter blues or SAD: light therapy.

I have tried lights in the morning but found that it caused agitation

I also received this feedback about increased agitation:

I have tried lights in the morning but found that it caused agitation. Over time my tolerance went down so that I could only use for less than 5 minutes. I haven’t ever tried midday light though. I’m not bipolar but I have depression which is generally worse in the winter. Exercise helps.

It may be worth trying midday light therapy if morning light therapy causes agitation or other adverse effects.

The press release mentions that light therapy is typically used in the morning to help reset circadian rhythms and the authors are unclear why midday light therapy worked for these patients with bipolar disorder. They plan to investigate further. If it is working via the same mechanism i.e. by resetting circadian rhythms, then it may well work at this time for other individuals too.

It may also be that your depression (and/or anxiety) is not caused by low serotonin but by something else instead – such as low catecholamines, poor thyroid health, gluten issues, poor diet and so on.

Using light therapy and tryptophan (or 5-HTP)

I have also found that some people do well on a combination of light therapy and tryptophan (or 5-HTP). One of my clients had many low serotonin symptoms and did better mood-wise and with reduced anxiety, on a small amount of tryptophan but still needed additional serotonin support. Additional tryptophan was too much for him and increased his day-time sleepiness, but using a small amount of tryptophan together with light therapy was the ideal balance for him.

Have you used light therapy with success – for the winter blues or depression or bipolar disorder? Or even for anxiety?

Have you ever used it at midday or at other times?

And have you used light therapy in conjunction with tryptophan or 5-HTP?

BioIndividual Nutrition Mini-Course and Phenols

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My friend and colleague, Julie Matthews, BS, NC, Author of Nourishing Hope for Autism will be hosting the BioIndividual Nutrition Mini-Course as an online webinar for practitioners who make diet and nutrition recommendations. Customizing diets based on a person’s unique biochemistry and health needs is essential to healing chronic disorders.

Learn what it means to practice BioIndividual Nutrition, and how your clinical results can improve by using and customizing therapeutic diets.

The Mini-Course touches on each module of her advanced BioIndividual Nutrition Training program; providing immediately actionable clinical insights, pitfalls to avoid, and proven tips to help you increase your effectiveness with specialized diets.

By the end of this online mini-course, you’ll have a good understanding of how practicing BioIndividual nutrition can help you become more confident, streamline your practice and improve compliance! Whether or not you enroll in the full program semester… You will discover:

  • 14 Clinical Tips you can use in your practice today
  • The nutrition science behind therapeutic diets including low phenol, low oxalate, low amine, low glutamate and low FODMAPs
  • Symptom clues on how to assess your client’s bioindividual nutrition needs
  • 5 most common mistakes nutrition practitioners make
  • Breakthrough case studies

Julie shares this:

This BioIndividual Nutrition Mini-Course will NOT be a general overview. Come prepared to learn!

This sampling of valuable information from the section on phenols and sulfation gives you an inkling on the level of detail Julie goes into when she teaches this topic:

This isn’t an area I’ve covered yet on my blog but as you can see there is much relevance when it comes to depression, irritability, agitation and anxiety, autism, ADHD and insomnia and more.

If you have questions Julie will be setting aside some time for Q&A right after the mini-course.

You can register for the online BioIndividual Nutrition Mini-Course here

My Kid is Not Crazy and PANS/PANDAS awareness day 2017

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Earlier this week was PANS/PANDAS awareness day 2017 so I’d like to bring some awareness to this condition that causes sudden-onset OCD (obsessive compulsive disorder) type symptoms and anxiety. The PANDAS Network defines PANDAS as follows:

PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) occurs when strep triggers a misdirected immune response results in inflammation on a child’s brain. In turn, the child quickly begins to exhibit life changing symptoms such as OCD, anxiety, tics, personality changes, decline in math and handwriting abilities, sensory sensitivities, restrictive eating, and more.

PANDAS Network estimates that PANDAS/PANS affects as many as 1 in 200 children.

This Huffington Post article: Misdiagnosed: How Children With Treatable Medical Issues Are Mistakenly Labeled as Mentally Ill covers one family’s experience with misdiagnosis with their daughter and the treatment that eventually helped her recover. As you’ll read in the blog, PANS/PANDAS is still very poorly understood in the medical community and misdiagnoses are very common:

the vast majority of pediatricians, child psychiatrists, and neurologists are unapprised of the latest research and continue to misdiagnose children who have PANS/PANDAS with any number of mental health disorders.

The new movie My Kid Is Not Crazy is another great resource for gaining a better understanding of this condition. Here are some snippets from this excellent movie:

Nine-year-old Kathryn was a normal, healthy child. She was a star student, athlete and dancer. In a matter of days, she would become totally dysfunctional. Kathryn had alarming rapid-onset OCD refusing to eat or drink. She had tremendous separation anxiety and would become panicked if her parents were not in sight. She had trouble sleeping and showed signs of age regression in vocabulary and handwriting.

How did this happen?

Kathryn’s family and many families like them— turned to a fractured medical system, where there is fierce disagreement about how to help their daughter. More often than not, a child with these symptoms would be diagnosed as having mental illness. They’d be treated with anti-psychotic medication, behavior therapy, and even hospitalization.

But more than 30 years ago, Susan Swedo—a doctor with the National Institutes of Health—discovered that an undiagnosed strep infection was the cause of one child’s disabling illness. The more Swedo dug, the more evidence she found: Strep was linked to symptoms normally chalked up to psychiatric illness.

She also discovered how non-accepting modern medicine can be of new ideas.

Swedo has put her reputation and career in jeopardy as she fights to cure the condition she named: Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS). Neurologists Jonathan Mink, Roger Kurlan, Harvey Singer and others publically ridicule Swedo and her PANDAS theory, creating controversy over diagnoses and treatment. This group has become known on social media as the “non-believers.” The result: the entire pediatric-care industry is confused and doesn’t know what to do.

And it’s the children who suffer.

“My Kid is Not Crazy,” a film by Tim Sorel, tracks the journey of six children and their families as they become tangled in the nightmare of a medical system heavily influenced by the pharmaceutical industry. Here it’s common for a caregiver to prescribe a young child with a Selective Serotonin Uptake Inhibitor (SSRI) but hesitate to prescribe an antibiotic to counteract a potential infectious-based trigger. For some of these kids, what happens after several years is shocking and sad.

You can watch the trailer here and rent the movie to watch it online or purchase the DVD here.

The movie site also lists many helpful resources for PANS/PANDAS.

Last week’s blog: Anxiety, compulsive thinking, counting behaviors: gluten, tryptophan and inositol covered gluten, tryptophan and inositol for OCD symptoms. I mentioned that I also always keep Lyme disease, heavy metals and PANDAS on the list as possible areas to refer out for if symptoms are not resolving with the above nutritional approaches, so it made sense to share more about PANDAS this week.

Even if the OCD and anxiety is due to PANS/PANDAS, I would still encourage a gluten-free diet and trials of tryptophan, GABA and inositol (and other nutritional approaches) in order to provide some relief while the infection/s are being addressed. Similar results are seen when providing nutrient support like the use of GABA (and/or tryptophan) for relief for Lyme anxiety.

Do you know about PANS/PANDAS and the connection to OCD and anxiety?

Have you seen symptom resolution by addressing the infection/s one of your children, personally or with a patient or client?

Have you seen some symptom relief when also using GABA and/or tryptophan and/or inositol?

Anxiety, compulsive thinking, counting behaviors: gluten, tryptophan and inositol

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Today I’m going to share my feedback on a question I received on how to approach working with a child with anxiety, compulsive thinking and counting behaviors in the hope it can help you or someone you know (or are working with if you’re a practitioner). Here is the question:

Regarding anxiety and compulsive thinking/OCD counting behaviors in a 12 year old, have you experienced (or heard through client sharing) a correlation with certain foods or inflammatory compounds? In a younger person, I am trying figure out the triggers if there is low production of certain neurotransmitters driving the symptoms. This child in particular has had a long history of allergies and terrible asthma (requiring nebulizer treatments) so I’ve long suspected food sensitivities as a driver for systemic inflammation but am trying to connect the dots for her parent. The counting seems to be a distraction of sorts for her – I assume following a triggering thought. This parent is very new to integrative therapies so treating with an amino acid is going to *feel* like she’s not doing enough as parent. Standard talk therapy has not helped.

This is how I responded and it’s how I would start to work with a parent with a child with these types of issues.

After looking at the basics to make sure the child is eating real whole food with no additives, is not consuming any caffeine and is getting quality animal protein at breakfast (to keep blood sugar stable and reduce anxiety), I always consider gluten and even dairy and other food intolerances. I write about the success of a gluten-free diet with a 7 year old boy in this blog: Integrative Medicine Approach to Pediatric Obsessive-Compulsive Disorder and Anxiety. He saw a “marked reduction of OCD symptoms and anxiety along with marked improvement of social behavior and school work.”

OCD and counting behaviors are classic low serotonin symptoms and her anxiety could be the low-serotonin worrying type or the low GABA type which is more physical anxiety. I’d have them do the amino acid questionnaire

I’d start with a trial of tryptophan – using 100mg of Lidtke Chewable Tryptophan – to help with the OCD, counting and worry-type anxiety. If it helps, I’d have her use it twice a day mid-afternoon and evening, increasing it over the course of a few weeks to find the ideal amount for symptom relief (and keeping a food mood log to record doses and symptoms).

Some people do really well with tryptophan, others do better with 5-HTP for low serotonin symptoms, so doing a trial with 25mg of 5-HTP would be an option if the tryptophan doesn’t help as expected.  

I would carefully review the precautions with the mom as tryptophan and 5-HTP can sometimes be an issue with asthma and may need to be lowered or discontinued.

Inositol can be added if additional nutritional support is needed for the OCD and counting behaviors and may even be needed to replace the tryptophan or 5-HTP if either one triggers asthma. The maximum dose in the research is 18g of inositol per day and I start at 2g once a day and increase slowly over a few weeks to find the ideal dose. Here is feedback from one mom on how inositol alone helped her son with migraines, stress, anxiety and OCD

Once we’ve figured out nutritional support for the low serotonin symptoms then we’d address low GABA if needed, using sublingual GABA.

I found this comment to be rather unusual: “treating with an amino acid is going to *feel* like she’s not doing enough as parent.” The parents I work with are thrilled to discover how powerful the amino acids are and how quickly they provide amazing results.

These other factors would also be addressed: possible high cortisol, gut health and any of the other possible contributing root causes. I also always keep Lyme disease, heavy metals and PANDAS on the list as possible areas to refer out for if symptoms are not resolving with the above approaches.

Here are links to the amino acid questionnaire, the precautions and the supplements:

  • I have my clients complete the Amino Acids Mood Questionnaire from The Antianxiety Food Solution and check off their symptoms in each of the sections. The rating uses scale of 1-10 with 10 being worst.
  • I also have my clients review the Amino Acids Precautions and we figure out which amino acids they can and can’t use
  • These are some of the supplements I use with my clients

Have you used any of the above approaches with your child or for your symptoms or for a client/patient?

Prosperity online viewing – can you help change the planet?

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YOU can help change the planet. YOU have the power to help mold the future, change the trajectory of human history and help us enter the safest AND most prosperous era we’ve ever experienced.

My amazing friend Dr. Pedram Shojai has put thousands of hours and a lot of blood, sweat and tears into creating what many are describing as a masterpiece.

His brand new documentary Prosperity takes an incredible look into exactly how companies are bringing together passion, purpose and profits for the benefit of every person on earth.

Here is a short trailer of the movie:

Pedram shows us the problems AND the companies and individuals who are changing the way they do business and make a profit all while helping HEAL the planet in the process. This documentary actually provides answers to some of the most important questions of our time.. and MOST importantly it gives us HOPE.

He shares that “companies can be a force for good” and we need to stop rewarding corporate greed. YOU can be part of this!

Here are some wise words of wisdom from the documentary:

  • “it’s like we’re reckless teenagers unaware of the consequences”
  • “we need a new definition of prosperity, one that includes our values”
  • “why do we continue to buy from companies that don’t do good – people talk about having values but then support companies that don’t have the same values”
  • “companies can be a force for good” and we need to stop rewarding corporate greed
  • “now there is an emphasis on the triple bottom line which measures the impact on people and planet along with profit”

Pedram is making his new movie Prosperity available to watch at no cost for 10 days and 10 days only… and I’d love to invite you to see this exclusive online screening with me.

Prosperity will eventually be shown across the country in theaters, but you can watch it online now for the next 10 days. You can register to watch it here and discover just how powerful your voice can be.

I’ll be watching it with you (again – I did get a sneak preview – I always like to do this before promoting something)

Let us know what you think and what changes you plan to make.