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Coronavirus: new research on vitamin D supplementation possibly improving clinical outcomes

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coronavirus and vitamin d

It’s very encouraging to see research like this being published in the midst of the coronavirus pandemic: Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus-2019 (COVID-2019)

Serum 25(OH)D level was lowest in critical cases, but highest in mild cases. Serum 25(OH)D levels were statistically significant among clinical outcomes.

The results suggest that an increase in serum 25(OH)D level in the body could either improve clinical outcomes or mitigate worst (severe to critical) outcomes, while a decrease in serum 25(OH)D level in the body could worsen clinical outcomes of COVID-2019 patients.

In other words,  lower levels of vitamin D were associated with more severe symptoms and higher levels were associated with less severe symptoms. The role of vitamin D in immunity has been long understood and is summarized in the paper as follows:

Vitamin  D has  been  proven  to reduce  risk  of  getting a common  cold. It  also  enhances cellular immunity, modulates adaptive  immunity, and  enhances expression  of  antioxidation-related genes.

There are a few aspects I’d like to highlight: it was not a peer-reviewed randomized controlled trial but rather a retrospective study (looking back on past events) submitted as a research letter; it was a small study of 212 cases and they were all confirmed to have SARS-CoV-2 infection.  Vitamin D status was based on serum 25(OH)D levels of “(1) normal -25(OH)D of >30 ng/ml, (2) insufficient-25(OH)D of 21-29ng/ml, and (3) deficient-25(OH)D of < 20 ng/ml,” with tests done every 7 days.

What is astounding to me is that such a small difference in vitamin D levels could have such a dramatic impact on severity of symptoms i.e. from a median of 31.2 ng/ml to 17.1 ng/ml:

  1. mild – mild clinical features without pneumonia diagnosis: serum 25(OH)D level was 31.2 ng/ml
  2. ordinary – confirmed pneumonia with fever and other respiratory symptoms: serum 25(OH)D level was 27.4 ng/ml
  3. severe – hypoxia (at most 93% oxygen saturation) and respiratory distress: serum 25(OH)D level was 21.2 ng/ml
  4. critical – respiratory failure requiring intensive case monitoring: serum 25(OH)D level was 17.1 ng/ml.

The author concludes as follows, recommending randomized controlled trials and large population studies:

… this study provides substantial information to clinicians and health policy-makers. Vitamin D supplementation could possibly improve clinical outcomes of patients infected with COVID-2019. Further research should conduct randomized controlled trials and large population studies to evaluate this recommendation.

I would really like to acknowledge the author, Dr. Mark Apilio, for taking the time to gather this information and submit this research in the midst of the pandemic, so we can all learn and further our knowledge.

I reached out to him to find out more about his interest in vitamin D. I was also curious to find out if vitamin D levels are routinely checked in the Philippines and if vitamin D supplementation recommendations are common practice. I received this feedback:

I am a clinical professor with experience in handling patients with infection. In times like this, academicians in the Philippines are driven to finding therapeutic drugs for Covid-19 or palliative drugs, at least. Also with other experts’ advice, Vit D could be a good topic to research using clinical outcomes of the Covid-19 patients.

Vitamin D supplementation in the Philippines is uncommon since most of the Filipinos believe that they could get Vit D easily because of the sun (country near the equator). However, Vit D test is common for patients with severe respiratory infections for monitoring of status. Based on the table [in the review letter], mean ± SD was used to report serum 25(OH)D level of the cases. I am happy with the results of the study and the support of Vit D advocates like you. I do hope this shall serve as a call for health officials to at least focus on something like this which could impact clinical outcomes of Covid-19 patients.

Keep in mind that low vitamin D is also a factor when it comes to mental health and anxiety. You can read more about this aspect here – Vitamin D: anxiety, depression, sun exposure, supplements and optimal levels. This blog also has additional information about testing and optimal ranges from the Vitamin D Council.

I really like these two Designs for Health products: Vitamin D Synergy which provides Vitamin D3 2000 IU and vitamin K1; and Vitamin D Supreme which provides Vitamin D3 5000 IU and vitamin K1/K2. Both can be purchased via my online supplement store (details on setting up an account here).

Vitamin D is such a simple and yet powerful intervention for immune support and I look forward to randomized controlled trials for coronavirus. In the meantime, it’s one of the many immune-supportive nutrients I plan to continue using and recommending to my clients.

UPDATES 5/1/2020:

I’m sharing some updates to last week’s blog on vitamin D and coronavirus because there is a brand new study with astounding results and some other supporting vitamin D papers.  There is also new research on vitamin K and coronavirus and I’ve added this one too. I did hear back from the author in the Philippines and added his feedback above.

This is the new paper with astounding results. It was a retrospective cohort study: Patterns of COVID-19 Mortality and Vitamin D: An Indonesian Study (and just posted April 26). It had 780 cases with laboratory-confirmed infection of SARS-CoV-2 in Indonesia:

Age, sex, co-morbidity, Vitamin D status, and disease outcome (mortality) were extracted from electronic medical records. The aim was to determine patterns of mortality and associated factors, with a special focus on Vitamin D status. Results revealed that the majority of the death cases were male and older and had pre-existing conditions and below normal Vitamin D serum level.

These are the astounding results:

  • Vitamin D deficient cases (serum 25(OH)D of < 20 ng/ml) were approximately 19.12 times more likely to die from the disease
  • Vitamin D insufficient cases (serum 25(OH)D of 21 – 29 ng/ml) were approximately 12.55 times more likely to die from the disease

This review paper, Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths published earlier in April makes these recommendations about dosages and vitamin D levels to aim for (pending additional research):

To reduce the risk of infection, it is recommended that people at risk of influenza and/or COVID-19 consider taking 10,000 IU/d of vitamin D3 for a few weeks to rapidly raise 25(OH)D concentrations, followed by 5000 IU/d. The goal should be to raise 25(OH)D concentrations above 40-60 ng/mL (100-150 nmol/L). For treatment of people who become infected with COVID-19, higher vitamin D3 doses might be useful. Randomized controlled trials and large population studies should be conducted to evaluate these recommendations.

In this paper (not yet peer-reviewed), Reduced Vitamin K Status as A Potentially Modifiable Prognostic Risk Factor in COVID19, the authors report that vitamin K status – according to Dp-ucMGP levels – was reduced in patients with COVID-19 and related to poor prognosis.”

They state this is due to the fact that “Coagulation is an intricate balance between clot promoting and dissolving processes in which vitamin K plays a well-known role.” They also propose an intervention trial with vitamin K for patients with COVID-19.

Do share if you routinely get your vitamin D levels checked and supplement regularly with vitamin D.  And let us know if you’ve noticed an improved immune system when your vitamin D levels are optimal. If you did get the virus please also let us know how you’ve fared and recovered.

Coronavirus: my immune boosting and antiviral plans (and what to use if you’re anxious)

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coronavirus immunity

 

3/27/20: Updated with a good blog post on elderberry (addressing cytokine storm concerns); an excellent video on “The Coronavirus Explained”; 3 new and promising coronavirus/COVID-19 studies on gut health and melatonin; an excellent hand-washing video I encourage you to watch with your families; a recap on using GABA, tryptophan, DPA, glutamine and tyrosine for emotional support

3/20/20: Updated with webinar information so you can post your questions.

3/12/20: Updated as a result of the situation in Italy and the WHO pandemic declaration – Italy overwhelmed with not enough ICU beds and ventilators; predictions the USA healthcare system (and other countries) will likely not be able to handle a similar situation; stay home and immune-boosting advice from Dr. David Brady; additional resources from Dr. Elisa Song; and more on hand-washing

1/31/20: Originally published – vitamin C and foundational nutrients; my other immune boosting nutrients and first aid kit; GABA or tryptophan if you are worried, overly anxious or fearful

UPDATES 3/27/20:

Coronavirus explained, gut health, elderberry, melatonin and more

So much is changing so quickly and there is so much to learn about the coronavirus. I am spending all my time pouring through the literature, learning from other practitioners, reaching out to researchers and trying to connect some of the dots for you. For this reason I’ve decided to do an update each week to this blog and add new findings and relevant information for you.

I’ve updated this blog again TODAY with a good blog post on elderberry, an excellent video on “The Coronavirus Explained” and 3 new and promising coronavirus/COVID-19 studies on gut health and melatonin. I will be taking a deeper dive into these studies, sharing my perspectives related to the anxiety nutrition work I do. I also share an excellent hand-washing video I encourage you to watch with your families!  And a recap on using GABA, tryptophan, DPA, glutamine and tyrosine for emotional support.

Elderberry concerns about it triggering a cytokine storm – put to rest

There have been many questions about elderberry and concerns about it possibly triggering a cytokine storm. Suzy Cohen addresses all these concerns here: In Defense of Precious Elderberries

The misinformation you’re getting was based upon a research article that evaluated blood cells in test tubes. It was not a well-designed, placebo-controlled clinical trial. It was not even done on real live people (in vivo).

A number of my respected colleagues agree with her conclusions: “compounds from elderberries can directly inhibit the [flu] virus’s entry and replication in human cells, and can help strengthen a person’s immune response to the virus.” More here.

Understanding the Coronavirus

I found this video very helpful for understanding the coronavirus: The Coronavirus Explained & What You Should Do

 

New and promising coronavirus/COVID-19 studies on gut health

Here are two new coronavirus/COVID-19 gut health studies. I will be taking a deeper dive into these studies in a future blog post, sharing my perspectives related to the anxiety nutrition work I do. For now, here are the links.  It’s very preliminary research but if you tuned in to the recent Anxiety Summit 5: Gut-Brain Axis, you know how promising this is:

Although no specific antiviral treatment has been recommended to date, we speculate that probiotics may modulate the gut microbiota to alter the gastrointestinal symptoms favorably and may also protect the respiratory system

Nutritional and gastrointestinal function should be assessed for all patients. Nutritional support and application of prebiotics or probiotics were suggested to regulate the balance of intestinal microbiota and reduce the risk of secondary infection due to bacterial translocation.

Anxiety and fear were common in patients with COVID-19. Therefore, we established dynamic assessment and warning for psychological crisis.

I address anxiety in all the work I do an agree it needs to be at the forefront for everyone.  I take a deeper dive into GABA and theanine and the anxiety/sleep/immunity connections in this recent blog: GABA and theanine for easing anxiety, improving sleep and supporting immunity.

Melatonin as a potential treatment: new research

This in press and pre-proof paper on melatonin is also very promising: COVID-19: Melatonin as a potential adjuvant treatment:

Melatonin, a well-known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS [acute lung injury/acute respiratory distress syndrome] caused by viral and other pathogens. Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. Notably, melatonin has a high safety profile.

I will also be taking a deeper dive into this study in a future blog post, sharing my perspectives on serotonin, melatonin, anxiety and sleep.

THE best hand-washing video!

This is THE best hand-washing video I’ve come across. It was even retweeted and acknowledged by WHO Director General, Dr Tedros Adhanom Ghebreyesus.

I’m pretty sure I may have been missing my thumbs! What about you?

handwashing

I don’t know how to share a video from twitter other than share the twitter link so I hope you can watch it.

We’re using soap at home and have one designated person in our household of four adults going out to pick up food items. This is the time we use hand-sanitizer (and gloves). Here is another blog on How to Make Your Own Hand Sanitizer in case you’re in a similar situation to us and can’t find ingredients to make more. Suzy mentions vinegar and colloidal silver in this one and shares a number of practical recipes.

IV vitamin C, oxalates, anti-malarial drugs and losss of smell and taste

It’s so encouraging that New York hospitals are treating coronavirus patients with vitamin C.  There are, however, concerns for folks who have dietary oxalate issues (with both oral and IV vitamin C). I’ve been gathering feedback and research on this topic and will hopefully have more to share next week.

I also have some major concerns about the anti-malarial drugs chloroquine and hydroxychloroquine and will share those, together with my perspectives on the loss of smell and taste as a possible marker of infection.

 

bouquet of hope

Until then, here is another little “bouquet of hope” from our garden to you … My darling mom-in-law brought this lovely little arrangement to me in my home office earlier this week! Aren’t I a lucky girl!?

Amino acids for emotional support, good sleep and to prevent comfort-eating

Finally, don’t forget about the amino acids for added emotional and nutritional support (our needs are higher at a time like this):

  • GABA for physical tension and anxiety (more here)
  • tryptophan for excessive worrying and feeling fearful (more here)
  • glutamine if you’re not eating well and getting blood sugar crashes, and for gut healing (more here)
  • tyrosine if you just can’t focus and want to curl up in bed (more here)
  • and DPA if you’re feeling overly emotional and weepy, comfort-eating is your support right now (more here)

This blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the products that I use with my individual clients and those in my group programs.

Please feel free to comment on any of the above new developments and share what you are learning too. And do let me know if this format is helpful for you.

Keeping you in my thoughts! And keeping you informed and empowered so anxiety is less of an issue.

UPDATES 3/20/2020:

I’m planning a series of webinars to get your coronavirus questions answered:

  1. I’m planning to interview a health coach/colleague living in Italy/Germany right now and have her share her experiences about living in lock-down and more about the situation in Europe
  2. I’m planning to interview Dr. David Brady to share his patient protocols for immunity,  testing and much more
  3. I’ll be doing one with me talking about best how to deal with the anxiety, worry and laying awake until 3am fearful.  Anxiety and lack of sleep adversely impact immunity so we have to sort that out. I’ll also cover the many nutrients for anxiety that also support immunity
  4. I’m looking for an expert to talk about vitamin C and the risks for those with dietary oxalate issues, and other viable and safe options instead of vitamin C
  5. I’ll be interviewing a doctor on the role of melatonin in counteracting severe inflammatory responses such as pro-inflammatory cytokines. It’s being theorized that older individuals are being more impacted because of low melatonin levels and it’s because children have higher levels of melatonin they are less impacted.

I hope these will be helpful for you? What questions do you have for each webinar (please list the webinar # and the question/s when you comment below. Please don’t send your questions via email – as you can imagine we are receiving a large number of emails!) Let me know what other information you are looking for.

UPDATES 3/12/2020:

The situation in Italy has me concerned

At the time of initial publication of this blog at the end of January, I was in agreement with what the Orthomolecular Medicine News Service were suggesting – we were reading a lot of media hype.

I am not one for fear-mongering, but after reading this very sobering account by two Italian doctors 2 days ago, I am now much more concerned about the coronavirus for the folks who will be most severely impacted – the elderly and the immune-compromised.

In Italy they do not have enough ventilators or ICU beds. Dr. Jason Van Schoor shared warnings from a colleague working in Northern Italy:

I feel the pressure to give you a quick personal update about what is happening in Italy, and also give some quick direct advice about what you should do.

First, Lombardy is the most developed region in Italy and it has a extraordinary good healthcare, I have worked in Italy, UK and Aus and don’t make the mistake to think that what is happening is happening in a 3rd world country.

The current situation is difficult to imagine and numbers do not explain things at all. Our hospitals are overwhelmed by Covid-19, they are running 200% capacity

We’ve stopped all routine, all ORs have been converted to ITUs and they are now diverting or not treating all other emergencies like trauma or strokes. There are hundreds of pts with severe resp failure and many of them do not have access to anything above a reservoir mask.

Patients above 65 or younger with comorbidities are not even assessed by ITU, I am not saying not tubed, I’m saying not assessed and no ITU staff attends when they arrest.

We have seen the same pattern in different areas a week apart, and there is no reason that in a few weeks it won’t be the same everywhere

You can read the entire thread on Twitter here. At first glance there is skepticism and disbelief this could be happening but a trusted colleague in San Francisco has heard similar accounts from doctors she knows in Italy. It’s thanks to her that I started digging deeper into the situation in Italy and had my mind changed.

And this article in the New York Times was also just published confirming much of this: Italy’s Health Care System Groans Under Coronavirus — a Warning to the World. They they do mention doctors being muzzled which is very concerning. We need transparency if we are to learn.

Predictions the USA healthcare system (and other countries) will likely not be able to handle a similar situation

This article supports what is happening in Italy, with serious predictions for the USA (and presumably other countries too) – What does the coronavirus mean for the U.S. healthcare system? Some simple math offers alarming answers

What does an avalanche of uncharacteristically severe respiratory viral illness cases mean for our health care system? How much excess capacity currently exists, and how quickly could Covid-19 cases saturate and overwhelm the number of available hospital beds, face masks, and other resources …

….like in Italy where this is happening right now!

This is why I am now fully behind social distancing and staying home

I’m still of the opinion I need to focus on healthy living/eating and boosting my immunity (and it’s what me and my family are currently doing) but I am now fully behind social distancing, staying home, not attending big events and not traveling – so this virus can be contained as much as possible. Knowing what I now know about Italy makes this an easy decision which is why I’m sharing it here today – even if it is frightening.

Dr. David Brady, ND, author of The Fibro Fix, provides some basic advice on staying as healthy as possible in this recent video posted on Facebook. His is the calm voice of reason, sharing precautions to take during the COVID-19 pandemic and also fully supporting the social isolation and stay home message.  He does mention andrographis for antiviral support, garlic, elderberry, vitamin C, lauric acid (monolaurin), vitamin D, preformed vitamin A (as opposed to beta-carotene), zinc and echinacea as all good nutrients to consider for his patients and family.

Unfortunately, many of my colleagues are still saying it’s media hype, out of control fear-mongering, is not as bad as the flu and there is no way this could happen in a country like the USA, Australia, UK and elsewhere.  I know they’ll get on board with all this once they have this information too.

I sincerely hope I am wrong about this and things don’t get as bad as Italy. For now I’m playing it safe.

My hand-washing research

I got called out for not mentioning hand-washing when I first published this blog. My focus was to share my first-aid kit i.e. nutraceuticals I use but KT was is absolutely right

Hand hygiene is the single most important intervention for reducing healthcare associated infections and preventing the spread of antimicrobial resistance.

My assumption was that this is common knowledge but based on this statement in the same paper, perhaps this isn’t the case?

while tremendous progress has certainly been made in this field, a significant amount of work is yet to be done in both strengthening the evidence regarding the impact of hand hygiene and maximizing its implementation

With regard to what to use: antibacterial soap showed little added benefit compared with regular soap

Interestingly this paper also states “Hand hygiene is clearly effective against gastrointestinal and, to a lesser extent, respiratory infections. Studies examining hygiene practices during respiratory illness and interventions targeting aerosol transmission are needed.” I’m not sure of the implications of this for the coronavirus. For now I’m following the guidelines outlined in Dr. Song’s blog (below).

This 2017 Time article, Washing Hands In Cold Water Works As Well As Hot Against Germs, clears up what they say is often conflicting data and has some good guidelines from a study published the same year (it was looking at E. coli bacteria and not viruses): wash hands in cold water, at least 10 secs of lathering and use regular soap. Hand lotion afterwards seems to help too.

Additional resources

I’ve also got some blogs from colleagues to share with you so you have additional resources:

It’s an approach the physicians of the Orthomolecular Medicine News Service are recommending and it’s gives me a higher level of comfort in these days ahead.

As I mentioned above I do have some questions and concerns about this vitamin C IV approach (and high doses of oral vitamin C) for folks with oxalate issues (myself included) and for folks with G6PD deficiencies and hemochromatosis. I’ll share more as I learn more.

  • And this one from Dr. Song too – Handwashing and Coronavirus: Are you doing it the right way? I encourage you to watch the hand-washing demo videos she links to and show them to your children! This fact is astounding: “If 60% rather than 20% of air travelers maintained clean hands, it could slow down the spread of infections by almost 70%“
  • Dr. Song also shares How to Make a 60% Alcohol-Based Hand Sanitizer. “Washing hands with soap and water is the #1 recommended way to prevent the spread of Coronavirus. But if you don’t have access to soap and water, what can you do? The CDC recommends using a hand sanitizer with at least 60% alcohol.“
  • A blog from Paleohacks: Thieves Oil What It Is, Benefits & How to Make It. Use Thieves oil as a natural disinfectant around your home. “It’s great for wiping down counters, cleaning toys, disinfecting cutting boards, removing stale odors, freshening trash cans and gym bags, and even cleaning veggies.”

Originally published 1/31/20:

How are you handling all the coronavirus news? Worried? Anxious? Fearful? Or are calmly watching and listening and making sure your immune system is in good shape and you have natural antivirals on hand if necessary? (and updated 3/12/20 – are you taking the stay at home message seriously? much more on that below)

There are still many unknowns but I’ve been gathering some articles and resources for my own personal use. I’m not an expert in infections but since folks in my community are asking I promised to share my first-aid kit and rationale in a blog post.

I can help with the anxiety and fear aspect if all this doesn’t put your mind at ease. I cover how I use individual amino acids with my clients at the end of this blog post.

Vitamin C and other foundational nutrients

This newly published blog by Andrew Saul PhD, Vitamin C Protects Against Coronavirus, offers sage foundational advice that resonates with what I already know:

The physicians of the Orthomolecular Medicine News Service and the International Society for Orthomolecular Medicine urge a nutrient-based method to prevent or minimize symptoms for future viral infection. The following inexpensive supplemental levels are recommended for adults; for children reduce these in proportion to body weight:

Vitamin C: 3,000 milligrams (or more) daily, in divided doses.

Vitamin D3: 2,000 International Units daily. (Start with 5,000 IU/day for two weeks, then reduce to 2,000)

Magnesium: 400 mg daily (in citrate, malate, chelate, or chloride form)

Zinc: 20 mg daily

Selenium: 100 mcg (micrograms) daily

Vitamin C, Vitamin D, magnesium, zinc, and selenium have been shown to strengthen the immune system against viruses.

Additional rationale for vitamin C

In another blog by Andrew Saul PhD, Nutritional Treatment of Coronavirus, offers additional rationale for vitamin C: “Abundant clinical evidence confirms vitamin C’s powerful antiviral effect when used in sufficient quantity” and states that the “physicians on the Orthomolecular Medicine News Service review board specifically recommend at least 3,000 milligrams (or more) of vitamin C daily, in divided doses. Vitamin C empowers the immune system and can directly denature many viruses.”

It’s very encouraging to read that just 200mg a day“given to the elderly resulted in improvement in respiratory symptoms in the most severely ill, hospitalized patients.”

This statement from the above blog puts much of what is considered to be media hype and fear-mongering into perspective: (see below why I no longer feel this is media hype)

“The common cold is a coronavirus, and SARS is a coronavirus, so they are the same viral type” ~ David Jenkins, MD, Professor of Medicine and Nutritional Science, University of Toronto.

I do have some questions and concerns about using high doses of oral vitamin C and vitamin C IV for folks with oxalate issues (myself included). I’m actively seeking answers.

Vitamin D, olive leaf extract, oregano oil, elderberry, NAC and diet

Here are some additional links that I have found or were shared with me (thank you if you shared one of these with me!):

  • Vitamin D and the anti-viral state “These results support the hypothesis that vitamin D … may play a major role in the inhibition of viruses.” I’m very aware of the immune-boosting properties of vitamin D.
  • Olive leaf extract “decreased the duration of upper respiratory illness in high school athletes.” We always have this on hand and it appears to work well for me and my family so I’ll make sure to keep this in mind.
  • Oregano oil – per this article on Holistic Primary care “A number of preliminary in vitro or animal studies have shown that compounds in oregano oil are virustatic and virucidal against several viral pathogens.” I always have oregano oil on hand (and especially when flying) and it always works well for me at the first sign of any bug. I was pleased to come across this research even though we don’t yet have a human study.
  • Black elderberry liquid extract “displays an inhibitory effect on the propagation of human pathogenic influenza viruses” and has antimicrobial effects against bacteria responsible for infections of the upper respiratory tract. This is also a firm favorite in our household in the winter months and I seldom need more than one or two doses at the first sign of the sniffles.
  • N-acetyl-L-cysteine (NAC) “antioxidants like NAC represent a potential additional treatment option that could be considered in the case of an influenza A virus pandemic.” I’ll be giving NAC more consideration.
  • Here are some well-balanced perspectives from Peter D’Adamo on Facebook mentions drinking plenty of water, stocks, garlic (freshly crushed), onions, leeks, elderberry and Andrographis paniculata. He does say “Keep in mind these are just my opinions and observations over a thin veneer of facts.”

Consider lomatium?

Lomatium is not my first choice but I’m listing it here out of interest. Lomatium by Barlow Herbals “During the flu pandemic of 1917-1918, the root came into extensive use by the two Washoe Indian tribes near Carson City, Nevada.” I have yet to try this one but have heard Jane from Barlow Herbals talk about lomatium on a number of summits and I’m intrigued.

My first-aid kit

In summary, here is my first-aid kit: Vitamin C, zinc, extra selenium, vitamin D, magnesium, oil of oregano, olive leaf extract, black elderberry and Biocidin Throat Spray and Xlear Nasal Spray (the latter two are always on hand and I always also travel with them).

I also always have essential oils on hand: tea tree oil, eucalyptus, peppermint, rosemary, lavender and others. I’ll be adding sage per Dr. Elisa Song’s blog (see below).

This is pretty much what I always use other than adding in extra selenium, so it was very affirming to gather all this research.

trudy first aid kit
Here are just a few products from my first-aid kit.

GABA or tryptophan: if worried or overly anxious or fearful

If you’re feeling worried or overly anxious or fearful, the best way is to be informed and prepared. Interestingly, some of the very same nutrients mentioned above also help ease anxiety – vitamin C, zinc, vitamin D, magnesium and selenium and B vitamins – because they are co-factors for making neurotransmitters like serotonin, GABA and dopamine.

If all this information and being prepared isn’t enough to calm you down, then don’t forget the individual amino acids for quick relief. I use GABA for clients who are feeling physically tense and tryptophan or 5-HTP for worry-type of anxiety and if they are imagining the worst and can’t switch off their busy mind off.

We use the trial method to find the ideal amount for each person, starting low and titrating up based on symptoms and then down if not added benefits are seen.

You can find my most popular amino acid products on the supplements blog here (and with details for how to set up an account for my online store). You can find everything else I write about in the store too. Just be sure to work with your practitioner.

My thoughts are with you and all of those currently ill and those who will get ill. We will get through this together.

My hope is that you are less anxious and fearful as you become more informed.

Please share your immune-boosting remedies and your thoughts and plans.

As I mentioned above, these are resources and information I’ve gathered for my own personal use, and are in no way intended to be recommendations.

 

Could a daily moisturizer help to lower markers of inflammation and reduce anxiety, panic, PTSD, phobias and social anxiety?

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Could using a good quality moisturizer on a daily basis help to lower markers of inflammation (proinflammatory markers) and actually help reduce anxiety, panic, PTSD, phobias, social anxiety and other mental health symptoms, plus other chronic health conditions at the same time? Based on a new pilot study, I’m going out on a limb and saying this may well pan out to be true. And there is certainly no harm in making this a daily self-care routine until further research confirms this, certainly because of the other benefits of using a moisturizer.

New study: a skin moisturizer reduces markers of inflammation

Let’s take a look at this new study which reports how using a skin moisturizer actually reduces markers of inflammation in the body: Topical Applications of an Emollient Reduce Circulating Pro-Inflammatory Cytokine Levels in Chronically Aged Humans: A Pilot Clinical Study

Emollients are moisturizers that help keep the skin moist and supple by reducing water loss from the epidermis, the outer layer of the skin.

The study set out to mirror an animal study where skin problems in older/aged mice was tied to elevated markers of inflammation called cytokines. When epidermal function/skin health in the mice was improved, the circulating cytokine levels were reduced:

Thirty‐three aged humans were treated twice‐daily for 30 days, with ≈3 ml of an emollient, previously shown to improve epidermal [i.e. skin] function

Changes in epidermal function and levels of three key, age‐related, plasma cytokines (IL‐1β, IL‐6 and TNFα) were measured at baseline and after treatment.

Circulating levels of proinflammatory cytokines in the body, IL‐1β, IL‐6 and TNFα, were higher in the older adults before the use of the emollient. After topical use, i.e, using the cream on their skin twice a day for 30 days:

circulating levels of IL‐1β and IL‐6 normalized, while TNFα levels declined substantially.

The authors suggest larger clinical trials to confirm this connection between high levels of proinflammatory cytokines and chronic inflammatory disorders and to show how improving skin health by moisturizing may prevent chronic inflammatory disorders such as heart disease, type II diabetes, osteoporosis and Alzheimer’s disease in older adults.

The University of California explains the mechanism:

Our skin starts to deteriorate around age 50 with changes to epidermal pH, hydration, and the permeability barrier, which keeps water in and bacteria and other potential pathogens out. A loss of moisture and breaks in the permeability barrier cause the skin to release inflammatory cytokines. Ordinarily, these cytokines help to repair defects in the barrier, but in aging skin the barrier can’t be fixed as easily, so the inflammatory signals continue to be released, eventually reaching the blood.

This article and the study authors are suggesting this is an issue to be addressed with older adults and with respect to the above chronic diseases, but there is enough research on the role of inflammation on anxiety and other mental health conditions at any age, that this study had me perk up and take notice. Also, if you’re young and not moisturizing or living in a dry climate or have other factors contributing to inflammation (more on that below), could this be happening too? I believe it’s highly likely.

The role of inflammation on anxiety and other mental health conditions

Here is one of the many anxiety-inflammation studies: Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond, reporting that:

heightened concentrations of inflammatory signals, including cytokines and C-reactive protein, have been described in posttraumatic stress disorder (PTSD), generalized anxiety disorder (GAD), panic disorder (PD), and phobias (agoraphobia, social phobia), etc.

And concludes that:

targeting inflammation may serve as a potential therapeutic target for treating these fear- and anxiety-based disorders in the future

Inflammation plays a role in depression too. This paper, Role of Inflammation in Depression and Treatment Implications reports that:

Numerous studies (including meta-analyses) have found elevated peripheral and central inflammatory cytokines and acute phase proteins in depression.

The ongoing inflammation affects neurotransmitters and makes antidepressants less effective:

Chronic exposure to increased inflammation is thought to drive changes in neurotransmitters and neurocircuits that lead to depressive symptoms and that may also interfere with or circumvent the efficacy of antidepressants.

Many approaches for reducing cytokines and inflammation

I do want to address the one statement in the emollient study where they say that “approaches that reduce circulating cytokines are not yet available.” There are, in fact, many approaches for reducing cytokines and inflammation.

In one study vitamin D supplementation improved mood, reduced anxiety and lowered markers of inflammation (CRP and IL-10) in female diabetics who had low levels of vitamin D.

In another study looking at anxiety in women with PCOS (polycystic ovary syndrome), probiotics and selenium improved their mental health and hormonal profiles, lowered markers of inflammation and reduced oxidative stress.

This paper lists a number of underling root causes that cause systemic inflammation and depression: psychosocial or life stressors, poor diet, physical inactivity, obesity, smoking, altered gut permeability (i.e. leaky gut), atopy (a genetic tendency to allergies – this could include gluten sensitivity), poor dental health, sleep issues and vitamin D deficiency.

Of course, these factors may also play a role in anxiety and using a functional medicine and nutritional approach, you can reduce the inflammation and eliminate the anxiety/depression. It’s a matter of finding your root cause/s and addressing them.

Research is also finding that GABA, one of the main calming neurotransmitters, may also have a possible role in “neuroimmune interaction, being involved in the modulation of immune cell activity associated with different systemic and enteric inflammatory conditions.”

Low zinc and low vitamin B6 are also factors in inflammation, and addressing low levels reduces inflammation and eases anxiety such as pyroluria (a social anxiety condition) and low GABA and low serotonin anxiety because zinc and vitamin B6 are co-factors for making these brain chemicals.

The benefit of touch and a boost of oxytocin

I’d like to mention other benefits of using a daily moisturizer – the benefits of touch, massage and a boost of oxytocin:

  • Hand massage and therapeutic touch has been shown to decrease anxiety and make the elderly in a nursing home feel more comforted. If you’re a caregiver to a parent, make daily moisturizing part of your routine.
  • Swedish massage reduces anxiety in ICU patients and improves vital signs.
  • Touch increases the release of oxytocin improving well-being and may also have “applications in neuropsychiatric disorders especially those characterized by persistent fear, repetitive behavior, reduced trust and avoidance of social interactions.”

Adding skin moisturizing to your daily self-care routine

I feel very comfortable saying you now we have a new tool – daily skin moisturizing – to add to your toolbox to help lower your markers of inflammation and reduce anxiety, panic, PTSD, phobias and social anxiety. Let’s use everything at your disposal to heal and feel your absolute best.

It’s something most women (and a few men) are already doing, and this information can give you more reason to continue to do it.

It’s a lovely self-care routine if you’ve not been doing it for some time or have never regularly used a moisturizer. This information can be an incentive to add it back to your daily routine or start doing it.

The biggest problem I see with moisturizing is using toxic chemicals and less than ideal creams on your skin so I reached out to colleagues and my community on Facebook to get input on their favorite home-made and store-bought moisturizers:

In the meanwhile, feel free to share your favorites and what your moisturizing self-care routine is like, and if you get regular massages and use moisturizing creams with love ones. Simply comment below.

The best food-mood-nutrient topics of 2017

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As we move into 2018, it’s time to recap and share the best of 2017 – from both blog posts and facebook posts. Hopefully these topics have helped you move forward as you address your anxiety symptoms and will help you (and your clients/patients if you’re a practitioner) take even bigger leaps as you move into 2018!

Most popular blog posts

Here are the most popular blog posts of 2017, based on comments and questions. If you have already read one of these and found it interesting at the time of publication, it’s worth a re-read for all the valuable comments/questions and my feedback.

Collagen and gelatin lower serotonin: does this increase your anxiety and depression?

I see everyone raving about gelatin and collagen – and rightly so – they have amazing health benefits. However, no-one is addressing the fact that gelatin is actually used in tryptophan-depletion studies to lower serotonin.

Some people get more anxious and depressed when consuming collagen, some do just fine and some even use it to lower their serotonin. Many need to use it with added tryptophan. I recently made some additional updates to this blog and have more to add so stay tuned for more on this topic.

How much GABA should I use and which GABA product is best?

There is no simple answer! It requires a blog post to provide a good answer because we are all unique, have different needs and these needs can even differ at different times depending on the issue and what is going on in our lives at the moment.

My Kid is Not Crazy and PANS/PANDAS awareness day 2017

PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) occurs when strep triggers a misdirected immune response results in inflammation on a child’s brain. In turn, the child quickly begins to exhibit life changing symptoms such as OCD, anxiety, tics, personality changes, decline in math and handwriting abilities, sensory sensitivities, restrictive eating, and more.

Anxiety, compulsive thinking, counting behaviors: gluten, tryptophan and inositol

Today I’m going to share my feedback on a question I received on how to approach working with a child with anxiety, compulsive thinking and counting behaviors in the hope it can help you or someone you know (or are working with if you’re a practitioner)

DPA for weepiness, pain and comfort and reward eating

This amino acid is a favorite with so many of my clients because it helps with [weepiness, pain and comfort and reward eating] by boosting your endorphins and when you chew a capsule you feel like you just got a big hug.

How to Beat Anxiety and Resolve Panic Attacks with Targeted Amino Acids: Wellness Mama podcast

I share my wonderful interview with Katie, the “Wellness Mama”. We talk about my favorite topic: How to Beat Anxiety and Resolve Panic Attacks with Targeted Amino Acids, with some extra questions about pregnancy and nursing that I’m not often asked about.

GABA for the physical-tension and stiff-and-tense-muscles type of anxiety

I’m going to review some GABA products for the physical-tension and stiff-and-tense-muscles type of anxiety, and share some additional resources for you….

I share that sublingual is best, do a trial and start low, my favorite GABA products and when it works and when it doesn’t.

Tryptophan for the worry-in-your-head and ruminating type of anxiety

I’m going to review some tryptophan products for the worry-in-your-head and ruminating type of anxiety… Lidtke is the only brand of tryptophan that I recommend simply because I see it work so well and because of quality issues with tryptophan in the past.

I also share when to use tryptophan and when to use GABA, and tryptophan for PMS.

GABA: an amino acid supplement for neurotransmitter support and anxiety relief

I recently attended the first international meeting of International Society for Nutritional Psychiatry Research and was honored and thrilled to present my poster – GABA: an amino acid supplement for neurotransmitter support and anxiety relief Because you were not able to be there, here are the contents of my poster word for word.

How GABA eases agonizing rectal pain and spasms in under 2 minutes

Proctalgia fugax is described as a condition that leads to rectal spasms and sharp fleeting pain in the lower rectum or anus. In some people it can be more than fleeting and is often described as excruciating and agonizing.

I have experienced this awful anal sphincter spasm and pain myself so I want to shine some light on this condition and offer the simplest and most effective solution: oral and sublingual GABA. It works to completely eliminate the pain in 1-2 minutes! And it can also be used to prevent a full-on spasm if you catch it in advance.

Migraines, Anxiety and Antiphospholipid Syndrome: on the Chronic Headache & Migraine Summit

The autoimmune condition called Antiphospholipid Syndrome (APS) is one of many possible contributing factors for both migraines and anxiety.

Cognitive impairment, strokes and livedo reticularis is common.

GABA protects against hypothyroidism caused by fluoride and reduces anxiety

To the best of our knowledge, this is the first study to establish the therapeutic efficacy of GABA as a natural antioxidant in inducing thyroprotection against fluoride-induced toxicity.

GABA for children: ADHD, focus issues, irritability, anxiety and tantrums

My daughter hasn’t been diagnosed with ADHD but has a lot of ADHD qualities. We were having a huge amount of behavior problems as she is getting older (she’s 11). I did some research and went to the health food store and bought a bottle [of GABA Calm]. At this point I was mentally exhausted from all the fighting and drama at home and at school. I was desperate and didn’t want to put her on any hard medication.

She has had amazing behavior at school and at home since giving it to her. She’s almost like different child. GABA has truly changed our life. She’s been taking it for almost 2 months.

Anxiety: when to use GABA and tryptophan and how much to use

When you have anxiety it can be confusing trying to figure out the root cause. I like to start by assessing for low GABA and low serotonin because when you address these with targeted individual amino acids you typically see results right away and feel hopeful (and now have time to look for other root causes like gluten issues, high cortisol, gut issues, dietary changes etc).

But there may still be some confusion about when to use GABA and when to use tryptophan and how much of each of these amino acids to use.

Vulvodynia: oxalates, GABA, tryptophan and physical therapy

I just listened to the webinar talking about oxalates. I was shocked and delighted to hear the mention of the connection between high oxalates and vulvodynia.

Research shows there is serotonin involvement with vulvodynia and SSRIs are often prescribed, as are benzodiazepines. My recommendation is trials of tryptophan and/or GABA.

Seriphos Original Formula is back: the best product for anxiety and insomnia caused by high cortisol

If you have high nighttime cortisol (as measured by an adrenal saliva test) it can cause insomnia and anxiety. Using 1-3 x Seriphos about 1-3 hours before the high cortisol is the best way I know for lowering the high cortisol and providing relief.

The product was reformulated and didn’t work like it used to and then the original formula was brought back.

GABA takes some of the anxiety edge away and now I want to add tryptophan: how do I do this?

I would say this – ask yourself what low GABA anxiety symptoms (this is the physical anxiety) have improved with the GABA and how much (rate each one before – out of 10; and what are they now – out of 10). From your question it sounds like they could improve more – so if we were working together I’d continue to increase GABA before adding something new.

The most popular facebook posts

And here are some of the most popular Facebook posts on TrudyScottAntianxietyFoodSolution (based on comments and shares). Many of these link to other sources like the research or other blogs with additional information. Most of them have a great back and forth discussion on the Facebook post so feel free to join in there.

Canola oil linked to worsened memory and learning ability in Alzheimer’s

Canola oil is one of the most widely consumed vegetable oils in the world, yet surprisingly little is known about its effects on health. Now, a new study published online December 7 in the journal Scientific Reports by researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) associates the consumption of canola oil in the diet with worsened memory, worsened learning ability and weight gain in mice which model Alzheimer’s disease. The study is the first to suggest that canola oil is more harmful than healthful for the brain.

Canola oil is not something I’ve ever recommended and I’m really glad to see this research. You have to read labels because it’s in a lot of salad dressings and processed foods!

Nestle to buy vitamin maker Atrium Innovations for $2.3 billion

The following brands are now owned by Nestle: Garden of Life, Douglas Laboratories, Pure Encapsulations.

This is not good! Other than the fact that the formulations will likely be changed, there is much to be said about Nestle and their ethics.

The Big Vitamin D Mistake

This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter. Actions are urgently needed to protect the global population from vitamin D deficiency.

Do you use a zinc supplement every day?

1) how much and what form? and with or without copper?
2) how did you decide to add zinc (or was it recommended by a practitioner)
3) how did you assess your zinc status (alk phos? zinc challenge/tally? mood symptoms? white flecks on nails? poor digestion? pyroluria questionnaire? blood work? other?)
4) how it helps you? (less anxious? more social? less depressed? less cravings? better digestion? better skin? less aches/pains? better blood sugar control? less PMS/hormone symptoms? better adrenal health? better immunity? other?)

Scary new information about benzodiazepine deaths

The five most frequently occurring drugs found in decedents were ethyl alcohol (5,318), benzodiazepines (5,167, including 1,851 alprazolam occurrences), cocaine (2,882), cannabinoids (2,292), and morphine (2,040).

With teen mental health deteriorating over five years, there’s a likely culprit

In a new paper published in Clinical Psychological Science, my colleagues and I found that the increases in depression, suicide attempts and suicide appeared among teens from every background – more privileged and less privileged, across all races and ethnicities and in every region of the country. All told, our analysis found that the generation of teens I call “iGen” – those born after 1995 – is much more likely to experience mental health issues than their millennial predecessors.

What happened so that so many more teens, in such a short period of time, would feel depressed, attempt suicide and commit suicide? After scouring several large surveys of teens for clues, I found that all of the possibilities traced back to a major change in teens’ lives: the sudden ascendance of the smartphone.

Gabapentin and pregabalin are as problematic as benzodiazepines

Crippling toll of the new valium that’s ruining the lives of MILLIONS

Can you relate to the term high-functioning anxiety?

Busy and in control. High-achieving and perfectionistic. Driven by details and order in a desperate attempt to calm racing thoughts, worry, and the fear that invade every ounce of the mind and body. An over-thinker with a tendency to perseverate, dwell, and stew on everything.

I used to be like this before the panic attacks and it’s a big clue that it’s time to do something about it but too often we push and push and push and then it gets really bad. I would love to be able to reach women (and men) at this stage before it gets really bad!

Great article about squatting and the benefits

How often do you squat? and do you use a device like the Squatty Potty?

Screen time might boost depression, suicide behaviors in teens

A new study finds that teens, especially girls, who spend several hours per day on phones and tablets are more likely to be depressed and have suicide-related outcomes.

When it comes to cravings, addiction and appetite we have this research supporting the use of glutamine

– Glutamine and glutamatergic metabolism is a factor in cravings and alcohol dependence
– A combination of tyrosine, lecithin, glutamine and 5-HTP helped withdrawal syndromes and mental symptoms in detoxified heroin addicts
– Glutamine has been shown to decrease secretion of ghrelin, the hormone that impacts appetite regulation. High levels of ghrelin appear to make high-calorie foods look more appealing.

Why the vaginal mesh scandal could be ‘bigger than thalidomide’

More than 92,000 women had vaginal mesh implants between 2007 and 2015 in England, and about one in 11 is said to have complications. More than 800 of these women are now taking legal action against the NHS and mesh manufacturers.

Please be aware of the dangers of vaginal mesh (and other procedures that use mesh) – it’s something I’ve always warned my clients about and it needs to become common knowledge

Do you take probiotics on a daily basis and do they help? Have you had to stop taking probiotics because of any adverse effects?

Melatonin–estrogen interactions in breast cancer

Individualized protocols in Dr. Nalini Chilkov’s OutSmart Cancer system include melatonin at 10-20mg at bedtime (to match nature’s cycling of melatonin…not for sleep issues) . MANY breast cancer patients have low or aberrant melatonin patterns.

The anti antidepressant. Depression affects 16 million Americans.

One third don’t respond to treatment. A surprising new drug may change that: ketamine.

I’m quite surprised how many women who are smart and savvy when it comes to eating and natural health continue to color their hair (or straighten or perm or treat).

I’m curious if you are one of those people ? And if yes why? Do you know the risks or would you just prefer not to know?

Excellent article on toxic sunscreen ingredients

I have always avoided conventional sunscreens and teach my clients about this but wish more people were aware of these issues. It’s not just sunscreens either…so many skin care products, makeup, hair products and household products have ingredients that are endocrine disrupters, cause DNA and oxidative damage and affect our health – both physically and mentally! What sunscreen do you use?

My favorite protein powder

I love this one because _______. I use it in these ways ______, _______, ________.

Right now my favorite protein powder is a pea protein (made by Nuzest). I love this one because it’s gluten-free, dairy and soy free, GMO-free and is pea only (no other ingredients!). I just found out it’s also available in USA and other countries.

My favorite healthy protein bar

I love it because _______ AND/OR I tried ______ and don’t like it because ________. My clients are always looking for protein bars for a quick healthy snack but so many are loaded with sugar OR don’t have enough protein and fat OR are full of processed soy OR contain a ton of nuts OR aren’t gluten-free.

Thank you for being such a huge part of this community, for sharing your stories and successes and for offering words of encouragement to others in the community. Thank you too, for asking your questions. Keep the questions coming – they keep me on my toes and help me to learn too!

I’d love to hear how the above topics have helped you and what topics you’d like me to cover in 2018, plus which areas you’d like me to take an even deeper dive into.

Vitamin D: anxiety, depression, sun exposure, supplements and optimal levels

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vitamin-d
(image from Vitamin D Day website http://www.vitamindday.net/)

It was Vitamin D Day on November 2nd and it was a day to recognize vitamin D deficiency as a world problem. The day is led by the Vitamin D Society, Vitamin D Council and GrassrootsHealth, non-profit organizations dedicated to spread awareness on the vitamin D deficiency pandemic. According to the Vitamin D Day site:

Researchers agree that at least one third of the world is deficient in vitamin D, and some scientists even think a greater percent of people are deficient in vitamin D.

Why are so many people deficient, you might ask? It’s simple really. We get vitamin D from sun exposure. And now, more than ever, the world’s population lives an indoor lifestyle, avoiding the sun daily.

Doctors are beginning to discover that vitamin D deficiency is a risk factor for many diseases, including heart disease and cancer.

Furthermore, they’re discovering that vitamin D deficiency may make some diseases more severe, like respiratory diseases and autoimmune diseases like multiple sclerosis and lupus. And they’re discovering that vitamin D can be an important piece in the treatment of some illnesses and diseases, including multiple sclerosis, cystic fibrosis, asthma and many other diseases!

Low vitamin D is also a factor when it comes to mental health. Even though this information is not listed on the Vitamin D day site, there is much research supporting the connection:

There is a strong association between low S-25(OH)D and higher negative and depressive symptoms in psychotic disorders.

In women at risk for depression, early pregnancy low vitamin D levels are associated with higher depressive symptom scores in early and late pregnancy.

Participants with higher serum vitamin D (serum 25-hydroxyvitamin D) levels were significantly less likely to report problems with depression and anxiety.

Serum vitamin D status is related to the occurrence of anxiety in post-stroke patients and may be an independent risk factor of [post-stroke anxiety] after 1 month.

Here are eight key factors to know about vitamin D for Vitamin D day:

  1. Vitamin D comes from sun exposure, not your diet.
  2. Scientists and doctors agree that at least a third of the world is deficient in vitamin D.
  3. If you don’t get frequent moderate sun exposure or take a vitamin D supplement, you’re likely deficient in vitamin D.
  4. Moderate midday sun exposure is the best for making vitamin D.
  5. You don’t need to burn to make vitamin D.
  6. Vitamin D supplements are a good option in the wintertime to get the vitamin D you need.

In the northern hemisphere, the sun starts focusing more on the southern hemisphere. The sun’s rays strike the northern hemisphere at a different angle, an angle that isn’t quite as intense as during the summer. In consequence, your body has a harder time making vitamin D in the winter compared to the summer. The further north you live, the more difficult it is to make vitamin D in the winter.

Remember you can always check to see if you’re making vitamin D by looking at your shadow. If it’s longer than you, you aren’t making much vitamin D. And in the winter, your shadow is often longer than you.

Have no fear that you can’t make vitamin D! Vitamin D supplements are a good option in the wintertime. Low-pressure sunbeds and UV light units are also options to help you make vitamin D during the winter.

  1. Vitamin D is important for many things, including your bones, heart, respiratory system, brain [and mental health], and likely cancer prevention.
  2. Consider getting tested for vitamin D, to see if you’re getting enough.

Vitamin D tests are pretty easy. You can ask your doctor to add it to your next routine blood panel, or you can order an in-home test online through the Vitamin D Council.

vitamin-d-1
(image from Vitamin D Day website http://www.vitamindday.net/)

Here are the vitamin D range guidelines from various organizations and the recommendations from the Vitamin D council:

vitamin-d-2

This blog post by the Vitamin D Council helps you to interpret your results: I tested my vitamin D level. What do my results mean?

When you get your test results you will see a number in units of ng/ml, for example, 50 ng/ml. These are the units that health professionals in the United States use. Elsewhere in the world, vitamin D blood test results are given in units of nmol/l.

  • To convert a test result measured in ng/ml to one measured in nmol/l, multiply the ng/ml number by 2.5. For example, 20 ng/ml is the same as 50 nmol/l (20 x 2.5).
  • To convert a test result measured in nmol/l to one measured in ng/ml, divide the nmol/l number by 2.5. For example, 50 nmol/l is the same as 20 ng/ml (50÷2.5).

This great Sunshine Calendar shows the amount of time needed to produce sufficient vitamin D.

vitamin-d-3
(image from Vitamin D Day website http://www.vitamindday.net/)

And this graphic shows why most of us aren’t getting enough vitamin D and why we need to supplement and get more sunshine exposure.

vitamin-d-4
(image from Vitamin D Day website http://www.vitamindday.net/)

To learn more about vitamin D, please visit Vitamin D Council, Vitamin D Society, GrassRootsHealth and the Vitamin D Day website.

Do you have your vitamin D levels tested at least once or twice a year? Are they in the 40-80ng/ml range?

And do you spend time in the sun and supplement?

Reduced anxiety in forensic inpatients – long-term intervention with Atlantic salmon

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wild-salmon
Wild salmon (picture used with permission: Vital Choice

Seafood is a great source of amino acids, omega-3 fatty acids, zinc, iodine, iron, calcium, selenium, and vitamins B12, A, and D, many of which are beneficial for mood disorders.

Fish in the diet has a positive impact on depression

A number of studies have found that including fish in the diet has a positive impact on depression, especially those that refer to traditional diets (the famous one is by Jacka and colleagues) and the Mediterranean diet (there are a number of studies by Sanchez-Villegas et al). A study from Finland found that the prevalence of depression was lower in countries where consumption of seafood is high.

When it comes to diet and nutrients there is much more research on depression than anxiety, so when my book The Antianxiety Food Solution was published in 2011, I wrote the following:

Given the link between anxiety and depression, it’s possible that seafood consumption could also help reduce the incidence of anxiety.

A study that now shows reduced anxiety with fish consumption

We have a study that now shows this: Reduced anxiety in forensic inpatients after a long-term intervention with Atlantic salmon

In the study, 95 male forensic patients were randomly assigned to one of two groups:

  • a Fish group where they consumed Atlantic salmon three times per week from September to February OR
  • a Control group where they consumed other protein sources such as chicken, pork, or beef three times per week, also from September to February

The paper lists the incidence of the following disorders amongst the study participants (all sexual offenders) who were in a secure forensic inpatient facility in the USA:

Personality disorders (antisocial personality disorder, borderline personality disorder or personality disorder with antisocial traits) were diagnosed among 76% of the participants. Moreover, about 31% of the participants were diagnosed with some kind of anxiety disorder (GAD, OCD, PD or post-traumatic stress disorder) and about 18% were diagnosed with depression (major depressive disorder or depressive disorder). About 31% of the participants had both a personality disorder and an anxiety or depressive disorder.

The study findings

The study participants consumed salmon for 6 months and the study findings suggest that

Atlantic salmon consumption may have an impact on mental health related variables such as underlying mechanisms playing a key role in emotion-regulation and state-anxiety

And that

The present results showed that fatty fish consumption caused changes in HRV [heart rate variability] which is regarded as an essential underlying biological mechanism involved in anxiety and emotion-regulation.

A few interesting factors about this study

  • The salmon was farmed and mercury and dioxin levels were measured. Despite this, mental health benefits and reduced anxiety was observed. I suspect even more favorable results would have been observed had wild salmon been used
  • The authors mention that a longer intervention as in this study i.e. 23 weeks/6 months is likely to lead to better results than a shorter intervention
  • The Fish group had a significant increase in both omega-3 fatty acids: EPA and DHA
  • The authors speculate about how improved vitamin D status in the Fish group may help regulate serotonin production and thereby help regulate heart rate variability and reduce anxiety
  • The study highlights nutritional benefits of fatty fish other than marine omega-3 fatty acids and vitamin D: selenium, iodine, vitamin B12 and high quality proteins. I’d like to add that it is a source of zinc and iron too, both of which are co-factors for making brain chemicals.
  • Although the study found a significant decrease in state-anxiety, it did not find any changes in trait-anxiety (here are the differences in state-anxiety and trait-anxiety). The authors suggest that trait-anxiety may be more difficult to change during a 6-month intervention study. I’d like to add that other concurrent nutritional and biochemical interventions would likely have provided additional mental health benefits. This could include: a gluten-free diet, targeted individual amino acids, addressing dysbiosis, addressing high or low histamine, pyroluria and zinc-copper imbalances and so on.

The authors mention a limitation of the study, in that this group of adult male forensic inpatients may make it difficult to generalize the results to other groups in the population and recommend further similar research in children and women.

I look forward to future research but I feel very comfortable about putting this limitation aside for now, especially with the positive results found with this group of patients with very severe symptoms.

I also feel very comfortable extrapolating these results from salmon to sardines and would expect similar beneficial results. I highly recommend selecting wild salmon or wild sardines rather than farmed.

If you suffer from anxiety and stress, or any mood disorder, I hope this research is further motivation to eat wild fatty fish a few times a week. How much fatty fish do you eat each week and have you observed mood or other health improvements?

And if you’re a practitioner, I hope this research is a bigger incentive to continue to recommend fatty fish to your clients or patients.

If you’re looking for some great recipes check out this yummy summer salmon pate recipe and this delicious pomegranate olive mint salsa to serve on grilled salmon. Vital Choice, a wonderful source for great quality home delivery WILD fish, has great recipes on their site too.