GABA

Glutamine for hypoglycemia/low blood sugar: “500mg mixed in water works in 15 minutes and keeps me going for 2 – 3 hours”

November 3, 2023 By Trudy Scott 27 Comments

Cat shared this feedback about how effective just 500mg of glutamine is for her low blood sugar and how quickly it helps:

I recently followed one of your posts on GABA down the rabbit hole to a linked blog post and then to another post where I found a mention of using glutamine for hypoglycemia. This is the only reference that I have read on this in 35 years of research on the subject. I follow a low carb, higher protein, healthy fat diet, but still suffer low blood sugar issues consistently at one particular time of the day. After so many years of eating a second breakfast to prevent the lows, I was ready to give any other healthy option a try.

It works!!! I found a powder that I mix approximately 500 mg of with water. It works within about 15 minutes and keeps me going for about 2 – 3 hours — long enough to reach a reasonable time for lunch.

I’m thrilled to have this option as anytime that I travel, low blood sugar becomes a huge issue as I suffer from ketotic hypoglycemia and end up with massive headaches and vomiting for 6-8 hours.

You have freed me from a huge weight! Thank you and hugs!

(And thank you for researching and sharing the tremendously helpful information in your books, webinar presentations and blogs.)

Thank you Cat for sharing your success and you are most welcome! I’m sharing this as a blog post because you may also be new to this.

Glutamine dosing, using powder vs capsules and using it on the tongue

Cat finds 500 mg glutamine works well for her unique needs. This is a good starting dose. I see many folks start too high, like 5000 mg / 5 g and up multiple times a day, and it’s not necessary. However, we increase based on individual needs and you may find you do need to use 500 mg -1000 mg two to three times a day.

Using a glutamine powder is a great way to use it especially if you find you do need more than 500 mg each time.

One thing I mentioned to Cat is when you use glutamine powder directly on to the tongue (rather than mixed in water), the benefits are seen more quickly i.e. right away rather than having to wait 15 minutes.

If you do start with glutamine capsules, be sure to open the capsule on the tongue too, But watch for fillers which can be irritating to some folks. Powders are typically glutamine-only and don’t taste bad at all. But when traveling, capsules may be a better option (at least when on a plane).

Ketotic hypoglycemia, adrenal dysfunction and breakfast

Ketotic Hypoglycemia International defines ketotic hypoglycemia as “a condition characterized by low blood sugar (glucose) and elevated ketones, typically occurring after fasting, like sleeping overnight. Ketotic hypoglycemia (KH) is not a disease itself but rather a symptom or a clinical presentation that can occur as a result of various underlying conditions.” I’ve asked Cat if she is aware as to what is causing her ketotic hypoglycemia and I’ll report back.

I have also asked if she has had salivary cortisol testing done as adrenal dysfunction plays a role in all types of low blood sugar and will need to be addressed. This can take awhile to test and figure out nutritional support. Until then, glutamine is wonderful for preventing low blood sugar episodes.

I’m also curious what her breakfasts look like and will update the blog when I find out. Cat does mention that she follows “a low carb, higher protein, healthy fat diet” so I assume her first breakfast is a good one. But it’s always something to confirm. As you can see on this blog, Anxiety and Hypoglycemia Symptoms Improve with Diet Modification, a healthy breakfast is key for blood sugar stability and preventing anxiety.

Low blood sugar symptoms and all the ways glutamine may help

This is the blog she commented on: Glutamine for calming, intense sugar cravings, gut healing and low blood sugar

I share all the symptoms we see with low blood sugar:

Crave sugar, starch or alcohol any time during the day
Irritable, shaky, headachey – especially if going too long between meals
Intense cravings for sweets
Lightheaded if meals are missed
Eating relieves fatigue
Agitated, easily upset
Nervous, anxious, panic attacks

As you can see, in addition to helping with low blood sugar symptoms, glutamine has calming properties (low blood sugar can also cause anxiety and panic attacks), helps reduce intense sugar cravings (sometimes described as a demonic urge to eat all things sweet and also helps with healing a leaky gut. Be sure to read these two blogs I’ve linked to above.

Glutamine has also been researched to help with addiction recovery. In this blog, An amino acid supplement with DLPA, glutamine and 5-HTP eases alcohol withdrawal symptoms at an inpatient detoxification program, glutamine is paired with two other amino acids.

Resources if you are new to using glutamine and other amino acids as supplements

We use the symptoms questionnaire to figure out if low blood sugar may be an issue for you.

If you suspect blood sugar or low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control (this topic has an entire chapter), sugar cravings, anxiety and mood issues.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs. You can find them all in my online store.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms too). This is a paid online/virtual group program where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

I really appreciate Cat for sharing her story and giving me permission to share as a blog.

Has glutamine helped you with low blood sugar/hypoglycemia? If yes, in what way has it helped – reduced anxiety, less sugar cravings (or other addictions), and not as irritable and cranky/angry?

And how much helps and how quickly? Are you using it on the tongue?

Has glutamine also helped with leaky gut?

If you’re a practitioner are you using glutamine this way with your clients/patients?

Feel free to share and ask your questions below.

GABA worked amazingly for 18-year-old during a MCAS/histamine flare, helping with OCD, anxiety, rage and skin issues

October 27, 2023 By Trudy Scott Leave a Comment

Bonnie shared how effective GABA was for her 18 year old son with suspected MCAS (mast cell activation syndrome/histamine issues) and his associated anxiety/OCD/rage and skin issues:

GABA worked amazingly for us during a flare! Flares began with OCD [obsessive compulsive disorder]and anxiety increasing before our eyes and then the rage followed.

He would wake up very early and his upper back, shoulders and upper chest would have acne all over, this would come and go, but never completely go.

GABA capsules worked in 20 minutes and thanks to you Trudy, I read and found GABA chewables worked in 5 minutes. We used to buy GABA all the time to stop the flares and to prevent them from coming! The GABA was absolutely 100% a godsend!

Once I started focusing on keeping histamine down, we don’t buy or use GABA much! Haven’t had a flare in almost a year!!

It’s so wonderful to hear that GABA helped Bonnie’s son so much. No MCAS/histamine flare in a year!

I checked with Bonnie and they primarily used 3 x Source Naturals GABA Calm chewables (each one contains 125 mg GABA). They initially used up to 3 x 250 mg GABA if he was having a really bad flare, 1 if he was not so bad and 2 if somewhere between.

Histamine issues frequently cause physical tension and anxiety so we’d expect GABA to help. Wth rage and OCD, we typically consider low serotonin as a possible cause but in her son’s case, GABA clearly was his root cause. I share another case where GABA helped ease symptoms of anger, rage, and dark moods.

It’s been a long road – ruling out PDD-NOS, PANDAS and PANS

But as amazing as GABA was for him there was more to it and it has been a long road for him. Bonnie shared this too: “At 4 years old he was diagnosed with PDD-NOS, then at 5 years old they said no it’s PANDAS, and at 6 years old no it’s PANS.”

Pervasive Developmental Disorder – Not Otherwise Specified (PDD-NOS) refers to a group of disorders characterized by impairment in the development of social interaction, verbal and non-verbal communication, imaginative activity and a limited number of interests and activities that tend to be repetitive.

Both PANDAS and PANS are associated with OCD, rages and other mental health issues which are often sudden onset and caused by infections – PANDAS is Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and PANS is when the severe onset of OCD symptoms is linked to another infection. More on these conditions here. It’s important to either rule out or address these conditions.

They tried several doctors and several protocols over the years: “B12 injections early but only saw a small gain. No reactions for years whatever we tried. IV treatment about 5 years ago was the second time we had gains.

Histamine was off the chart and flares were worse during allergy season and better in winter

I share all this to give you hope and to send the message that you don’t want to ever give up. Even with few gains, Bonnie persevered and started making the connections with allergies. She shared this: “During these years 2 different allergy tests matched and histamine was off the chart for both, but 2 different doctors did not address it. Maybe there was no connection then.”

She noticed flares were worse during the beginning of allergy season and better in winter, and started to histamine support:

We use DAO enzymes with high histamine foods. We tried quercetin, isoquercetin and curcumin with no gains. Started stinging nettles and bromelain and they are definitely helping us with gains.

Our son seems to be much better, being more social and we are just seeing better connections socially.

Just started Seeking Health Serotonin Nutrients to see if this can further add gains. Probably a different topic now! Sorry so long!! Love to share!!!

Bonnie noticed her son’s flares were better in winter but keep in mind there may be seasonality of GABA with worsening anxiety, insomnia and intrusive thoughts in winter (and the need for increased GABA supplementation). I blog about this here.

The research: Neurotransmitter and neuropeptide regulation of mast cell function

Bonnie shared her son’s results in response to a Facebook post where I shared the research that GABA (a well-known inhibitory neurotransmitter) helps with MCAS/mast cell activation syndrome and histamine issues.

This 2020 paper, Neurotransmitter and neuropeptide regulation of mast cell function: a systematic review, reports that:

Some reports link GABA to the inhibition of MC (mast cell) activation in allergies. GABA suppresses degranulation in rat basophilic leukemia RBL-2H3 cells via the GABA(B) receptor on the cell surface

….The administration of GABA in a dose-dependent manner reduced the development of AD [atopic dermatitis] – like skin lesions in mice by suppressing serum IgE and splenocyte IL-4 production.

(Keep in mind that the RBL-2H3 cell line mentioned in the above research is a commonly used histamine-releasing cell line used in inflammation, allergy and immunological research.)

My additional feedback about serotonin support and pyroluria

They also used (and still use) 5 mg lithium orotate and 100 mg 5-HTP. Bonnie will soon be stopping one at a time to see if that makes a difference. I’ll share what she reports back.

Bonnie mentions wanting to trial a combination product for serotonin support. I shared with her that I prefer individual amino acids so we know what’s helping. This is especially important with sensitive folks who may react to any one of the ingredients. My choice would be exploring 5-HTP further or doing a trial of tryptophan instead of 5-HTP (or possibly a combination of both) if there are still low serotonin symptoms.

She also mentions that her son is “more social and we are just seeing better connections socially.” This is great but if she feels he could make even more social gains I’d encourage looking into the pyroluria protocol too. There are many added benefits of addressing pyroluria (a social anxiety condition) when someone has MCAS, histamine issues, Lyme or another chronic condition. The zinc, vitamin B6 and other nutrients also support neurotransmitter production.

Resources if you are new to using amino acids as supplements

We use the symptoms questionnaire to figure out if low GABA or low serotonin may be an issue.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues.

I really appreciate Bonnie for sharing her son’s story and giving me permission to share as a blog.

Has GABA helped with your symptoms (or your loved one’s symptoms) triggered by MCAS/mast cell activation syndrome and histamine issues – like anxiety, insomnia, OCD, racing heart, rage, allergy symptoms and even rashes/dermatitis?

Do you also find that the sublingual/chewable GABA Calm product worked/works quicker than swallowed GABA products?

Has addressing pyroluria helped MCAS/histamine issues and social anxiety?

Feel free to share and ask your questions below.

Seriphos lowers high cortisol: prevent waking in the night and nighttime anxiety

October 20, 2023 By Trudy Scott 63 Comments

Seriphos is my favorite nutrient for lowering high nighttime cortisol in order to reduce night waking and nighttime anxiety. I’ve used it with success in the past and have just needed it again:

After coming back from Hawaii (I was there for just under 2 weeks), I was still waking a few times each night. Sometimes I would be awake for 2-3 hours! I’m a hot mess when I don’t get sleep through the night. With just 1 Seriphos before bed for 9 days I was sleeping through the night again. It was glorious!

High cortisol can be a temporary issue after international travel i.e. caused by jetlag and out of balance circadian rhythm. I will admit that I have a number of confounding factors – like my loss and grief (my darling mom has just passed away), being sprayed with insecticide on landing in Australia (which I suspect caused severe vertigo the day after I got back), and high blood pressure (and likely higher cortisol too) after drinking too much licorice tea for my voice loss. Whatever the causes of my high cortisol, Seriphos really helped me sleep through the night.

I ran out of Seriphos 2 nights ago and I was awake for 3 hours last night. I’ll be adding it back to my nighttime protocol as soon as my order arrives.

Seriphos is made by Interplexus and is a phosphorylated serine product. It is similar to the more recognized phosphatidylserine which is also used and known for lowering high cortisol – clinically and in the research. However, clinically, I have found Seriphos to be more effective and work more quickly.

UPDATE Feb 2024: I did end up tweaking my Seriphos dose a few times. After a few weeks I decided to trial 2 per night – this worked well. Then a few weeks later I trialed 3 per night – but after a few days I realized that even though it worked well for sleep it made me too tired the next day. For this reason I went back down to 2 Seriphos at bedtime.

UPDATE August 2024: I’m now using just 1 Seriphos at night and have added ox bile supplementation and a bright light panel in the morning because of bile issues. More on this below.

Seriphos for high cortisol due to trauma, loss of beloved cat and more

When I posted this on Facebook, I had a number of folks share how Seriphos has also helped them.

Kathy shared this: “I take two Seriphos at night for high cortisol that causes insomnia. It works well for me and helps me to relax. I have a significant trauma background that keeps me in fight or flight, so Seriphos is a must have at night. I do take a break from time to time if I am going through a less stressful time.”

Hopefully Kathy is also working on the trauma, doing trauma work and even incorporating other nutritional approaches which help so much with recovery – like zinc, vitamin D, a B complex, GABA and tryptophan etc. Taking a break from time to time is a good plan – I share more about this below.

Kim shared this: “Seriphos is a life saver – I started it when I was having cortisol/adrenaline issues a few years ago and have continued using it. I don’t ever want to be without Seriphos. A little over a month ago I unexpectedly lost my youngest cat. She was emaciated when I rescued her over 4 years ago and we turned around health issues. I feel so sad that she was dealt such a bad hand but we got her a loving home. My animals are everything to me and the grief is so difficult. She was a character and I love her so much.”

She uses one capsule in the evening but also uses a capsule during the day if she feels off. Hopefully Kim is also doing trauma work and other nutritional support too.

Janie shared this: “I have used it, years ago when my cortisol was off the charts, morning and at night. I was awake every night until 2am, unable to sleep. Seriphos certainly helped.”

She used 1 Seriphos per day for about 3 months.

Patricia said: “Please remember that there is Original Seriphos and the next gen Seriphos. I was one of thousands of people who had used original Seriphos for sleep and then they changed their formulation without telling us and then so very many of us were wide awake at night until we realized that they had changed the formulation.”

This happened in 2016/2017 and I blogged about that whole fiasco here – Seriphos Original Formula is back: the best product for anxiety and insomnia caused by high cortisol. You can read many other success stories on the blog and in the comments.

Address the causes of your high cortisol: jetlag, grief, toxins, licorice intake

As you can see from my example there can be a number of causes of high cortisol and you always want to address these causes while using Seriphos so you can eventually stop using it:

International travel i.e. caused by jetlag and out of balance circadian rhythm. I’m home so this is no longer a contributing issue.
Loss and grief can have physiological effects and high cortisol is one of many effects: “It appears that cortisol remains elevated for at least the first 6 months of bereavement. For some, cortisol elevation may become chronic”. The loss of my darling mom is going to take time but I am making time for grieving and I’m nurturing myself. As I navigate this period in my life I’ll continue to share what has helped me. I suspect I may need Seriphos for longer than the usual 3 months.
Being sprayed with insecticide on landing in Australia (which I suspect caused severe vertigo the day after I got back). It’s well-recognized that environmental toxins are hormone disruptors and affect the hypothalamic-pituitary-adrenal (HPA) axis and cortisol. I’m addressing this with active detoxification and my portable infrared sauna.
High blood pressure and likely higher cortisol too after drinking too much licorice tea for my voice loss. I have stopped the licorice consumption and my blood pressure is back to normal.

Other possible causes of high cortisol include day to day stresses, food sensitivities such as gluten, high sugar consumption, parasites and so on. Each factor needs to be addressed.

I do recommend Salivary cortisol testing before using Seriphos

Salivary cortisol testing is something I do with all my clients anyway. And I do recommend salivary cortisol testing before using Seriphos and the other cortisol-lowering nutrients mentioned below.

I will admit that I didn’t follow my own recommendation because I’ve had high nighttime cortisol in the past and recognized the symptoms. I had also identified all the above root causes and I desperately needed to sleep. I now have an adrenal saliva test kit on hand and will report back when I get the results.

Seriphos will only work for waking in the night if cortisol is high

One woman shared “I have never slept through the night in years. It would be delightful to get to the morning without waking.” Seriphos will very likely help if her cortisol is high.

Keep in mind there are many causes of not being able to sleep through the night and Seriphos will not help if cortisol is not high. Other root causes for insomnia/waking in the night (and nighttime anxiety) we consider and investigate are:

Low GABA and low serotonin (I always start with these while waiting for salivary cortisol results to come back),
Low melatonin

The following factors need to be addressed as root causes of sleep issues, anxiety and other symptoms (like gut issues, pain etc.), and also keep in mind that they are very possibly contributing to your high cortisol too:

Gluten and other food sensitivities
Caffeine and sugar intake
Oxalate issues and/or toxins exposure affecting bile production (this affected my sleep last year)
EMFs
Parasites and other gut issues like IBS/SIBO etc.
Disrupted circadian rhythms connected to liver/gallbladder/bile issues – more on that and bright light here. (Research does support a connection between high cortisol and cholestasis i.e. “stagnation, or at least a marked reduction, in bile secretion and flow.”)

A few folks reported they had tried Seriphos without success and it may well be that they don’t have high cortisol. Or they would possibly benefit from another approach to lower their cortisol (more on this below).

What are my options if I have high cortisol at night and Seriphos has the opposite effect?

One person said it had the opposite reaction. Joanne shared this: “Seriphos had the opposite effect on me. [One Seriphos] gave me extreme anxiety, kept me awake all night. Saliva tested consistently high cortisol at night so it should have helped. Been trying to work out why it would and how it might inform how I treat my insomnia.”

I’ve had a few clients do better with less than the recommended 3 per day and one not being able to use it at all. I suspect an allergic reaction or that it’s just too high a dose for some folks. The capsule could be opened and less could be used.

If this doesn’t work, other options for lowering high cortisol include lactium/hydrolyzed casein, Relora® (which contains Magnolia officinalis and Phellodendron amurense), essential oils such as bergamot and some herbal adaptogens. You can also read about some phosphatidylserine products I looked into when the Seriphos product was changed.

Forest bathing also helps to lower high cortisol levels and I recommend it for everyone.

Where does using Seriphos fit into everything else that I’m doing to address my insomnia and/or anxiety?

I typically don’t start with Seriphos right away with clients unless we know cortisol is high. As mentioned above I always start with assessing for low GABA and low serotonin and we do trials of the respective amino acids based on the symptoms questionnaire.

I also assess for low blood sugar and dietary factors like gluten, caffeine, sugar, quality animal protein intake etc. as covered in my book “The Antianxiety Food Solution.” More about my book here. It does include a chapter on the amino acids and how to use them too.

Then we start to dig deeper and would consider Seriphos or lactium for anxiety caused by high night time or even high morning cortisol or high cortisol at other times of the day.

With many folks all of the above often applies. And we continue with assessing for each of the 60+ nutritional and biochemical root causes of anxiety/waking in the night (which does include liver/gallbladder/bile issues).

Where do I purchase Seriphos and how much do I use? What about taking a break?

You can purchase Seriphos from my online store (Fullscript – only available to USA customers – use this link to set up an account) and you can also find it on iherb (use this link to save 5%).

The bottle states to use 1 capsule with water 15 minutes before a meal. Clinically, using 1-3 capsules a few hours before the high cortisol seems to be most effective. For 2-4am waking this typically means taking Seriphos right before bed. In some instances, taking 1 on waking in the night can help too (for a maximum of 3).

With high cortisol in the night and on waking, I have clients use Seriphos before bed and lactium on waking.

It is recommended to take a one-month break after 3 months of Seriphos use. Ideally, once the root causes of high cortisol are addressed, you should be able to stop anyway. Or take a break, retest cortisol and then continue.

I’ll share some research and how Seriphos differs from phosphatidylserine in a follow-up blog if there is enough interest.

I appreciate all the feedback from these women in my community.

Have you used Seriphos (a phosphorylated serine product) to help with high cortisol and waking in the night/nighttime anxiety caused by any of the?

What do you suspect the cause(s) of your high cortisol is or was? And have you confirmed high cortisol with a saliva cortisol test?

Have any of the other products mentioned above helped to reduce high cortisol? If yes, have you compared them with Seriphos?

Let me know if you’re interested in a follow-up blog that includes some research and how Seriphos differs from phosphatidylserine.

Feel free to share and ask your questions below.

My son has alcohol dependence and I want to help him quit drinking with GABA and other amino acid supplements

September 8, 2023 By Trudy Scott 15 Comments

My son has alcohol dependence and I want to help him quit drinking with GABA and other amino acid supplements. Alcohol and the benzodiazepines used in treatment both block GABA receptors, but I assume having GABA available in your system is better than none (especially as nutrition has been very poor). Have you an article on this? Thank you for your knowledge and understanding.

MJ posted this question on one of the GABA blogs and I shared a few blogs to get her started (some of those are listed below). I also shared that with addictions to alcohol (and sugar and drugs) it’s a matter of figuring out which amino acids are needed in order to balance the neurotransmitters and help you to quit with no willpower and without feeling deprived. This can differ for each person and it’s a matter of doing a trial of each amino acid based on unique needs.

He may well need GABA if he self-medicates with alcohol when under stress, but he may also need serotonin support with tryptophan or 5-HTP if he drinks when depressed and needs a mood lift.

I decided to create a new blog because it’s a much needed topic and so I could share additional resources and a table I use (see below) to help you figure out where your need may be. We use this in conjunction with the symptoms questionnaire for each neurotransmitter.

In addition to addressing her benzodiazepine question, I also shared the need to address low blood sugar, low vitamin B1 and overall nutrient status. She does mention nutrition has been poor and it often is with alcohol addiction.

Which emotions are driving the need to self-medicate with alcohol and which amino acids to trial?

This is how I help you figure out which emotions are driving the need to self-medicate with alcohol and which amino acids to trial:

How do you feel before drinking alcohol?	How do you feel after drinking alcohol?	Likely brain chemistry imbalance	Amino acid/s to supplement
Anxious or stressed (physical anxiety)	Calm or relaxed	Low GABA	GABA, pharmaGABA or theanine
Depressed or worried? (mental anxiety)	Happy or content	Low serotonin	Tryptophan or 5-HTP
Tired or unfocused	Energetic, alert, or focused	Low catecholamines	Tyrosine
Wanting a reward or treat, and sad (weepy)	Rewarded or comforted	Low endorphins	DPA (d-phenylalanine) or DLPA
Irritable and shaky	Grounded or stable	Low blood sugar	Glutamine

We use this in conjunction with the symptoms questionnaire for each neurotransmitter.

Many individuals with alcohol addiction have imbalances in all areas. We use the same approach when it comes to alcohol addictions that we use sugar/carb/junk food addictions i.e. we tackle one imbalance at a time so we know which amino acid is helping and how much is needed.

The amino acids play many roles in addressing alcohol addiction:

They help you to quit alcohol with no willpower and without feeling deprived
They help to mitigate many of the adverse effects of quitting (like insomnia and increased anxiety and depression)
They address the root cause of the addiction i.e. neurotransmitter imbalances
They address the emotional aspect so mood and anxiety is improved
They help to heal the damage that has been done to the gut: glutamine, GABA and tryptophan
They prevent the need to find a replacement like sugar, coffee, Diet soda and cigarettes (intake is often ramped up when drinking ceases)
They even help children who have had prenatal exposure to alcohol – 5-HTP benefits both adopted daughters who had prenatal exposure to alcohol: they are happier, more focused and can stay on task

PharmaGABA eases physical anxiety, amino acids ease alcohol withdrawal symptoms, and tryptophan turns you off alcohol

These blog posts illustrate the many applications of amino acids when it comes to quitting alcohol

PharmaGABA eases physical anxiety in a young man who has recently given up Adderall, alcohol and nicotine (some folks do better with GABA and some with pharmaGABA)
An amino acid supplement with DLPA, glutamine and 5-HTP eases alcohol withdrawal symptoms at an inpatient detoxification program
Tryptophan had the added benefit of turning me completely off alcohol when I took it to improve mood and sleep during perimenopause (this need for serotonin support could be applicable for a male too and at any age)

As I mentioned above, be sure to use the search feature to find other blogs on this site: use alcohol, addiction and sugar (and replace sugar with alcohol in the sugar blogs).

Does his prior benzodiazepine prescription prevent him from being able to use GABA?

MJ asks if her son’s prior benzodiazepine prescription will prevent him from being able to use GABA. He will need to taper very very slowly under the guidance of someone knowledgeable and with oversight by the prescribing physician.

It is true that GABA receptors can be affected by benzodiazepines but despite this, many of my clients and others in my community do get relief from GABA during the taper period and afterwards.

We do start with a very small dose – I typically have someone start with 25mg GABA and go up from there – and only use sublingual GABA (or pharmaGABA). For some very sensitive folks we will start even lower as in this example where Syd gets sleep and body anxiety benefits with just 1.5 mg to 3 mg GABA.

I share more on this blog – Rebound insomnia after tapering a benzodiazepine: will taking GABA or any other natural supplement interfere with healing?

One big caveat is that nutritional stability is key when it comes to tapering benzodiazepines. It is also imperative when it comes to addiction recovery.

Good nutritional status, low blood sugar and low vitamin B1

MJ does mention that her son’s nutrition has been poor. It often is with alcohol addiction. I also shared with her the need to address low blood sugar and overall nutrient status.

When you are new to the amino acids and anxiety nutrition solutions my book “The Antianxiety Food Solution” is an excellent resource for all of the above – and the information applies to those with addictions too.

Here is a blog with additional information and a study on the importance of addressing low blood sugar when it comes to anxiety and also addictions – Anxiety and Hypoglycemia Symptoms Improve with Diet Modification.

This highlights the importance of consuming enough protein, fats and fiber, especially at breakfast. There is an entire chapter on blood sugar in my book – it’s that important.

Finally, low thiamine/vitamin B1 must be addressed: “alcohol misuse is the most common risk factor for thiamine deficiency.” More about this here.

A complete nutritional assessment for other issues should be done too: low vitamin D, low zinc, other vitamin B deficiencies, low magnesium, adrenal insufficiency, leaky gut and more.

Medically assisted withdrawal treatment

If you are wanting to quit alcohol and don’t have an alcohol use disorder, all of the above approaches can be safely used.

However, medically assisted withdrawal treatment may be needed in some instances: “Excessive chronic alcohol users, and particularly patients with alcohol use disorder, may present an alcohol withdrawal syndrome if they abruptly stop drinking. Alcohol withdrawal syndrome requires pharmacological treatment for the treatment of withdrawal symptoms and to prevent withdrawal complications. Medically assisted withdrawal treatment is used in alcohol treatment units, but it is also frequently required in patients admitted to hospital for other conditions.”

It’s important that this is recognized for those who need it. MJ mentions benzodiazepines were used in her son’s treatment so presumably he had medically assisted withdrawal treatment.

In this situation, once her son has safely quit alcohol everything I mention above would then apply – looking at the amino acids and nutritional status so there is no relapse. And so recovery is easier and sustainable with a stable mood and no anxiety.

Resources if you are new to using amino acids as supplements

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues.

Have you or a loved one used the amino acids to help with alcohol dependence/alcohol use disorder?

If benzodiazepines were used in the treatment center, was GABA still helpful?

Have the amino acids helped prevent new addictions to sugar/coffee/cigarettes and improved anxiety, depression and insomnia?

If you have questions and other feedback please share in the comments too.

GABA and taurine reduce high blood pressure: the anxiety connection and what do when on blood pressure medication or if blood pressure is already low

September 1, 2023 By Trudy Scott 18 Comments

Gamma-amino butyric acid (GABA) is an amino acid that used as a supplement to help ease physical anxiety and help with insomnia, and a host of other symptoms ranging from pain to throat spasms (you can see the most recent list of symptoms here)

Research shows that GABA lowers blood pressure too. This has implications if you have high blood pressure/hypertension and are currently taking blood pressure medication or if you happen to have low blood pressure. The latter is already a precaution I review with my clients i.e. to watch the use of GABA when blood pressure is low. But we do need to add another precaution to cover folks already on blood pressure medications. Read on to learn about these precautions and what they may mean for you, and to read about the GABA (and taurine) hypertension research. And the fact that anxiety is common when you have high blood pressure and can actually be a driving factor.

This paper, United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA), published in 2021, reports the results of a 4-week study that investigated the tolerability of GABA supplementation in mildly hypertensive but otherwise healthy adults:

The authors first established an optimum dose in mildly hypertensive subjects (SBP/systolic blood pressure between 130 and 180 mm Hg) who were randomized to receive oral doses of GABA at 0 (placebo), 20, 40, or 80 mg/day for 4 weeks.

An intake of 80 mg/day of GABA was associated with a significant reduction of the BP in adults with mild hypertension, and no adverse effects were reported.

A subsequent study evaluated long-term effects of GABA at 80 mg daily versus placebo in mildly hypertensive subjects for 8 weeks:

At the end of the 8-week study, SBP [systolic blood pressure i.e. the top number] and DBP [diastolic blood pressure i.e. the bottom number] were on average 5% lower in all the subjects who received 80 mg/day of GABA compared to participants in the placebo group whose blood pressure levels remained above normal.

This is a substantial reduction when 80 mg of GABA a day is considered a very low dose. I typically have my anxious clients start with 125mg GABA and increase from there. They may end up using 125 mg GABA 3 or 4 times a day and sometimes 250 mg a few times a day.

I’m not suggesting using only GABA or taurine (more on this below) when blood pressure is high as there can be many variables and root causes. I would, however, like to see GABA be given more consideration, especially when anxiety is a symptom too.

The existing GABA precautions: a new one if you are taking medication for high blood pressure

If you are currently taking blood pressure medication for high blood pressure and plan to do a trial of GABA, it’s worth monitoring your blood pressure and discussing with your prescribing doctor. GABA may lower your blood pressure enough that your medication can be reduced or possibly stopped. The above paper states this:

Because some studies showed that GABA was associated with decreases in blood pressure, it is conceivable that concurrent use of GABA with anti-hypertensive medications could increase risk of hypotension [low blood pressure].

I have now added this as a new precaution – High blood pressure and on blood pressure medications: GABA, taurine. You can see it on the Amino Acid Precautions blog.

The existing GABA precautions: watch when you have low blood pressure and don’t use when pregnant or nursing

As you can read in the amino acids chapter of my book and on the above precautions blog, there is already a precaution stating to watch the use of GABA when you have low blood pressure. It’s worth being aware of but is not something I’ve actually seen to be an issue. Occasionally folks reduce their GABA dose because they feel light-headed.

This precaution is already addressed – not to use GABA when pregnant or nursing – but it’s worth repeating here as it’s a frequent question I am asked . The above paper states:

Caution is advised for pregnant and lactating women since GABA can affect neurotransmitters and the endocrine system, i.e., increases in growth hormone and prolactin levels.

Taurine: hypertension, stroke and heart disease

You’ll notice taurine grouped with GABA on the list of precautions. Based on the research, this amino acid also helps reduce blood pressure and is cardio-protective: “Advances in extensive studies on experimental models indicate that taurine is preventive against hypertension, stroke and atherosclerotic arterial diseases.”

This is one of the proposed mechanisms of taurine for lowering blood pressure : “The preventive mechanisms of taurine were ascribed to sympathetic modulation for reducing blood pressure (BP) and anti-inflammatory action.” GABA works in a similar way.

The same precautions would apply: low blood pressure and high blood pressure with blood pressure medication.

As I mentioned above, there is more to hypertension than adding only taurine or GABA. This book by Dr. Mark Houston MD, is an excellent resource – What Your Doctor May Not Tell You About(TM): Hypertension: The Revolutionary Nutrition and Lifestyle Program to Help Fight High Blood Pressure (my Amazon link).

He does mention taurine and recommends 1 to 1.5 g of taurine twice a day for high blood pressure. He does not mention GABA supplementation but does mention how vitamin B6 is important for GABA and serotonin production and improving sympathetic function.

Stress, anxiety and fear affect blood pressure and GABA helps

Dr. Houston shares that “numerous studies have linked stress, anxiety, fear and other negative emotions to an elevation in blood pressure. Conversely, as stress decreases, so does blood pressure. ”

This supports my comments above about giving GABA more consideration when it comes to high blood pressure, especially when anxiety is a symptom too. Here are some cases studies:

When GABA is not available taurine is a viable option for anxiety and hypertension.

Resources if you are new to using amino acids as supplements

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues.

If you have low blood pressure, has GABA (or taurine) been an issue for you?

Do you have high blood pressure and has GABA (or taurine) lowered it? If yes, how much did you use and how much did your blood pressure improve? And did you have to adjust your blood pressure medication (and which one)?

Has GABA (or taurine) helped ease your physical anxiety and other low GABA symptoms?

If you have questions and other feedback please share in the comments too.

“Potion” of tyrosine, Endorphigen, GABA and tryptophan has been nothing less than a miracle for my depression and anxiety – how long can I remain on these?

August 11, 2023 By Trudy Scott 21 Comments

Amy shares how much her particular “potion” or combination of amino acids has helped her depression and anxiety and wants to know how long she can remain on them:

I currently take 500 mg of l-tyrosine in the morning, 1 Endorphigen 2xday, 1 GABA calm 2x day and 1000 mg of tryptophan before bed with some natural calm & true calm. This “potion” has been nothing less than a miracle. I feel pretty good.

The past few years have been rough, managing depression and anxiety with frequent relapse, and I finally feel ok.

I don’t want to wean off yet and am curious as to how long I can remain on these. Is it dangerous to keep on it too long? Is there a maximum time? I follow your blog and reached out to you last year. Your information has been extremely helpful. Thank you.

I’m glad to hear Amy is doing so well on this miracle combination and finally feels ok. Before stopping the amino acids, the goal is to address diet, gut health, nutritional imbalances, toxins and all the underlying factors that lead to low catecholamines, low endorphins, low GABA and low serotonin.

It’s fine to stop taking them and see how you do and add some or all of them back if you find you still need that neurotransmitter support. This is one of a few approaches I use with clients. But here are times when it’s best to wait and continue using them (like when on the pill and when affected by seasonal depression). I share my insights on this and other ways to cut back below.

How long can you remain on amino acids and when do you consider stopping them?

There is no set time frame for staying on the amino acids. As I mentioned above you can stop taking the individual amino acids and see how you do and then add some or all of them back if you find you still need that neurotransmitter support. This is one of a few approaches I use with clients.

Other approaches include: completely stopping one amino acid at a time and monitoring symptoms or reducing the amount one amino acid at a time, also monitoring symptoms. I prefer the latter especially with someone like Amy who has been “managing depression and anxiety with frequent relapse.”

I can also hear that she has some hesitation about stopping her “potion” and going with your gut is a good thing too. She also has a few confounding factors that make me feel staying on them longer may be in her best interest. One factor is her long-term use of birth control pills.

Long term use of birth control pills and the impact on mood and nutritional status

Amy also shares about her use of the birth control pill and how she suspects it’s a factor in her depression and anxiety:

I should also mention I just went off birth control pills. I have taken them since age 16 only stopping for 3 pregnancies and breastfeeding. I am 46. I’ve been on for painful periods. I made the decision to stop for fear of clots, cardiac issues and most importantly my mental well being. I truly believe they contributed to my depression. I believe I’m in perimenopause and have higher than normal anxiety. I’m extremely worried about my periods if I stop the pill and think my amino acid supplements help these worries and I cope better. That’s why I’m reluctant to stop the supplements but still worried about long term use.

Because Amy has been using the birth control pill for around 25 years I’d have her continue with the amino acids for now and address the effects on her gut health and nutritional status first.

Women taking the pill and other hormonal contraception are more likely to be depressed. A Danish study published in JAMA Psychiatry of more than 1 million women aged 15 to 34, with no prior history of depression, were included in the study and followed for 13 years. The researchers found that those women who used the pill were 23% more likely to be depressed and use antidepressants.

You can read more about the effects of the birth control pill on this blog and my book review of “Beyond the Pill” by Dr. Jolene Brighten. As you’ll read it causes vitamin, mineral, and antioxidant depletion (such as folate, B12, vitamin B6 and zinc).

She did actually come back and share that she tried and it didn’t work out going off the birth control pill. She was unable to manage the pain. She needs to address all these root causes first.

There is also no reason for her to be worried about long term use of the amino acids when they are clearly addressing her neurotransmitter imbalances.

The seasonal impact on mood and anxiety

I don’t have clients make changes to their amino acids in the Fall or Winter when there can be seasonal impacts on mood and anxiety. She had shared this too:

I’m more prone to depression this time of year. I think with these 2 factors [seasonal mood changes and the pill] I’ll stay on the regime until the spring.

This is a wise decision for Amy.

I would also hold off on making changes if someone is prone to airborne allergies. This is because there can be a higher need for neurotransmitter support when there are allergies.

Amy has already made many diet and lifestyle changes so she is heading in the right direction:

I have given my diet an overhaul. Not perfect but significantly less refined carbs and sugar. Plenty of fresh produce, healthy fats and protein ( especially animal). I also have committed to daily “body movement”: yoga, Pilates, max trainer, light weights or bike.

All of these changes are starting to support her overall nutritional status and resilience.

A recap of the amino acids Amy is using and the rationale for each one

If you’re new to using individual amino acids, here is a quick recap of the amino acids Amy is using and the rationale for each one.

She is using 500 mg of l-tyrosine in the morning. This supports low levels of dopamine/catchecolamines and improves the curl-up-in-bed kind of depression. You can read more about tyrosine here.

She is also using Endorphigen twice a day. This is a Lidtke product called Endorphigen and provides 500 mg DPA/d-phenylalanine per capsule. It raises endorphin levels, offering a mood boost, typically helping with weepiness and also emotional eating. You can read more about DPA here.

Amy is also using GABA Calm 2x day. This is a sublingual/chewable product made by Source Naturals and is a nice low dose of 125mg per chewable. You can read more about GABA here.

And finally, she is using 1000 mg of tryptophan before bed. This supports low serotonin and improves worry-kind of anxiety and depression, ruminating, obsessive tendencies and also sleep issues. You can read more about tryptophan here.

Keep in mind this is what Amy found works for her unique needs and would have done trials of the amino acids one by one to figure out which ones to use and how much of each to use. There is no one size fits all.

It’s not unusual for folks using the amino acids to describe their results as miraculous!

Resources if you are new to using amino acids as supplements

If you are new to using amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the symptoms of neurotransmitter imbalances, including low GABA, low serotonin, low dopamine, low blood sugar and low endorphins).

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues.

Thanks to Amy for sharing her results and asking this question.

Have you seen similar benefits when using individual amino acids? If yes, which ones have helped you?

What approach have you used to stop or reduce your doses?

And have you continued using the amino acids because of the effects of the pill, seasonal mood shifts or seasonal allergies (or some other reason)?

If you have questions and feedback please share them here too.