Tryptophan

Sleep improvement: Oral intake of GABA and Apocynum venetum leaf extract

July 8, 2016 By Trudy Scott 17 Comments

sleep-improvement

I’ve blogged about the Sleep promoting effects of combined GABA and 5-HTP. There is another combination of nutrients that has been shown to help with sleep: GABA and the herb Apocynum venetum leaf extract.

In this 2015 paper: The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract

The electroencephalogram (EEG) test revealed that oral administration of GABA (100 mg) and [Apocynum venetum Leaf Extract] AVLE (50 mg) had beneficial effects on sleep.

In this study they found that GABA helps people to fall asleep quickly and Apocynum venetum Leaf Extract induces deep sleep, and that they work well when taken together.

The authors conclude that both GABA and Apocynum venetum leaf extract:

can be regarded as safe and appropriate for daily intake in order to improve the quality of sleep.

Earlier this year I heard Dr. Peter Bongiorno present at the Integrative Healthcare Symposium and one of the herbs he covered was Apocynum venetum leaf extract for depression. Since this was new to me, I invited him to share about this herb on the recent Anxiety Summit: Serotonin and anxiety: tryptophan, 5-HTP, serotonin syndrome and medication tapers

I also briefly mentioned the above GABA/Apocynum venetum leaf extract study in my talk on the recent Anxiety Summit – GABA: Blood brain barrier controversy, concerns, best forms and how to do a trial for eliminating anxiety

I find that many of my clients with anxiety also have sleep problems and GABA is often helpful if their sleep issues are related to low GABA levels, often manifesting as physical tension.

One of the signs of low serotonin, in addition to anxiety and worry, is insomnia and I find tryptophan (and sometimes 5-HTP) to be very helpful for many clients too. I’ll often have someone use both GABA and tryptophan (or GABA and 5-HTP) and the combination seems to be a good one.

I have not yet used Apocynum venetum leaf extract alone with clients or in combination with GABA and look forward to learning more. Have you have tried it alone or in combination with GABA? Have you used it with clients?

Tryptophan for PMS: premenstrual dysphoria, mood swings, tension, and irritability

July 1, 2016 By Trudy Scott 55 Comments

In a study published in 1999, A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria, tryptophan was found to reduce symptoms of PMS when used in the luteal phase or second half of the cycle (i.e. after ovulation):

37 patients with premenstrual dysphoric disorder were treated with L-tryptophan 6 g per day, and 34 were given placebo. The treatments were administered under double-blind conditions for 17 days, from the time of ovulation to the third day of menstruation, during three consecutive menstrual cycles.

They looked at dysphoria, which is defined as a state of unease or generalized dissatisfaction with life, plus mood swings, tension (and anxiety), and irritability and they found a 34.5% reduction of symptoms with tryptophan compared to 10.4% with placebo.

The paper concludes:

that these results suggest that increasing serotonin synthesis during the late luteal phase of the menstrual cycle has a beneficial effect in patients with premenstrual dysphoric disorder.

Let me share what I see with the women with PMS that I work with:

This is very typical when I’m working with someone with PMS and anxiety and other mood symptoms. It typically takes 2 to 3 cycles for an amino acid like tryptophan to have an impact on PMS itself. But it does typically start to work right away on the less severe anxiety and mood symptoms that may also be a factor during the rest of the month.
I don’t start with 6g per day of the tryptophan but rather have each person do the amino acid questionnaire, review the precautions and do a trial of tryptophan, increasing as needed to find the optimal amount for their needs (you can read more about this here on anxiety and the amino acid overview
We often find that adding GABA helps too, as this supports progesterone production
Many anxious women I work with also have pyroluria or signs of low zinc and low vitamin B6 and adding these nutrients, together with evening primrose oil, provide additional hormonal support (and help with the social anxiety).
Other factors to consider with PMS: low total cholesterol (as cholesterol is needed to make hormones), gluten issues, adrenal function and blood sugar control, gut health and the microbiome, and liver support
And finally, we can’t forget diet and need to switch to eating a real whole foods diet free from sugar, gluten and caffeine. Coffee and chocolate in the second half of the cycle can be especially problematic for many women

Together with the tryptophan and the above approaches (if needed as we are all so different), it’s not unreasonable to get the reduction of symptoms from 34.5% (as seen with the tryptophan) down to 100%. It breaks my heart when I hear women think they have to live with PMS symptoms when they don’t have to!

Have you used tryptophan for PMS? Do you take it all month or just in the 2nd half of your cycle? What about other changes that have helped: GABA or liver support or quitting caffeine? Or something else? Please share.

Tryptophan for anxiety, sleep and mood: in Put Anxiety Behind You

May 6, 2016 By Trudy Scott 90 Comments

Tryptophan is an amino acid I use with clients all the time. If you have the low serotonin symptoms of anxiety, worry, depression, insomnia, PMS, TMJ, anger issues, winter blues and afternoon/evening cravings, tryptophan can provide relief very quickly, provided you use a quality tryptophan product and find the right amount for your unique needs. I do a trial of each amino acid with my clients.

Dr. Peter Bongiorno, ND, a doctor of naturopathic medicine, also uses tryptophan with his patients. Here is an excerpt on tryptophan from his newest book Put Anxiety Behind You: The Complete Drug-Free Program:

Tryptophan (sometimes referred to as L-tryptophan) is a naturally derived amino acid that serves as a precursor to the neurotransmitter serotonin, which is needed to help you stay asleep. Low levels of tryptophan contribute to generalized anxiety and panic attacks. Back in the early 1990s, a laboratory I was associated with at Yale University performed “tryptophan depletion studies” and which volunteers who were already prone to anxiety were put on a tryptophan-free diet. Within days, these people were extremely anxious, panicky and unstable – and they had lots of trouble staying asleep.

I usually give people 500 – 1,000 mg of tryptophan at bedtime, but I may dose up to 2,500 mg. Take tryptophan at bedtime with a slice of simple carbohydrate (like an apple slice) – the carbohydrate will increase insulin levels and insulin will promote tryptophan absorption in the brain. In my clinic I use a supplement called Tryptophan Calmplete, which includes B vitamins.

Although most conventional psychiatrists are afraid to mix natural medicines like tryptophan with conventional medications studies suggest that they can be safely combined. One eight-week randomized controlled trial of thirty patients with major depression combined 20 mg of Prozac (an SSRI medication) with 2,000 mg of tryptophan as daily treatment for major depressive disorder. This study demonstrated that combining tryptophan and an SSRI improved mood and helped patients stay asleep.

If you look up tryptophan on websites like WebMD, they are going to tell you that tryptophan is unsafe. The reason for this is because in the early 1990s there was an incident of Eosinophilia Myalgia Syndrome, a condition contracted by thirty people who most unfortunately got sick (and some died) after ingesting tryptophan supplements. This tragic event occurred because the company making the supplement had no quality controls, and allowed the introduction of bacteria. These deaths had nothing to do with tryptophan itself. My sense is that the folks behind conventional websites WebMD, who should be doing their homework, let these ideas persist on purpose. The drug companies who advertise with these websites then benefit from continuing the misinformation. I have taken tryptophan myself, have used it with family members and countless patients with absolutely no problem save for the side benefit of better sleep and mood.

This book is an excellent resource for anxiety, where addressing nutritional imbalances with a supplement such as tryptophan is part of the bigger picture of addressing sleep, doing thought work and mind-body work, balancing hormones and blood sugar, exercising, adopting a healthy real foods diet, and making sure you have a healthy digestive system.

He uses the analogy of a stool – when one of the legs or supports is weak, your health suffers.

put-anxiety-behind-you-fig1

I’m a research-geek and love to be able to look at the studies so my only negative comment about the book is that all the studies mentioned in the text are not listed in the references and studies that are listed in the references are not numbered so they can be easily found in the text.

His other book Holistic Solutions for Anxiety and Depression: Combining Natural Remedies with Conventional Care is also excellent and is geared to therapists and other practitioners. You can read my review of that book here.

I had the pleasure of interviewing Dr. Bongiorno on The Anxiety Summit (season 3) – our topic: Serotonin and Anxiety, Happiness, Digestion and our Hormones. And I’m excited to share that he’ll be speaking on Season 4 of the Anxiety Summit. We’ll be taking a deeper dive into serotonin and tryptophan.

I also had the pleasure of meeting Dr. Bongiorno in person and hearing him present at the New York City Integrative Healthcare Symposium earlier this year.

peter-trudy

Dr. Bongiorno is co-director of Inner Source Natural Health and Acupuncture in New York City. President of the New York Association of Naturopathic Physicians, he is a contributor to numerous blogs and online magazines, including DrOz.com and Sharecare.com, and is regularly interviewed as a natural medicine expert on national television and radio.

Dr. Bongiorno has been kind enough to offer a copy of Put Anxiety Behind You: The Complete Drug-Free Program as a giveaway. We’ll do a drawing and select one lucky reader and announce the winner next Friday. If you’d like to be entered in to the drawing simply comment below and share:

~~why you’d like to win the book~~
~~if you’ve used tryptophan and what results you saw/see~~
~~which section you’re most excited about reading and why (just go to the Amazon preview via this link and check out the table of contents and sections of the book)~~
~~which holistic approaches you already use personally or if you’re a practitioner, what you have used with your anxious patients/clients~~

5/12/16 UPDATE: Thanks for participating and commenting – the winner is Liz. We’ll contact you to get a mailing address and get a copy of the book to you! Enjoy it!

If you missed out I encourage you to still check out the table of contents (with the look inside Amazon feature) and get the book if it feels like a fit for you. Check out the comments below to be inspired further.

Please share your feedback (and questions you may have) in the comments section below.

Tryptophan, red meat and baby steps for anxiety: the Brain Summit

May 1, 2016 By Trudy Scott 18 Comments

Just a quick reminder that the Brain Summit starts tomorrow, Monday, May 2nd.

brainsummit-trudy

Here are some snippets from my anxiety interview with host Erin Matlock. We started out talking about diet and grass-fed red meat and why it’s so beneficial if you have anxiety (and other mood problems):

…there’s a lot of research showing now that [a Western diet] diet is not good for so many conditions, and mental health is now coming into the research. And we know this, but to see it in the research is really beneficial. Dr. Felice Jacka did a great study in Australia that was one of the first studies that looked at anxiety and depression in women and found that the Western diet was associated with a higher risk for anxiety and depression. And this whole foods, traditional diet, that actually included grass-fed red meat, was more beneficial for anxiety and depression. And in her thesis, they actually looked at red meat thinking that they would find that red meat was actually detrimental. And, lo and behold, they found that grass-fed red meat was one of the most important predictors for good mental health. So a lot of people say, “I don’t eat red meat any more. I’m being healthy.” And in actual fact, not eating it is doing them harm.

So red meat is wonderful! And it needs to be grass fed because then you’re getting the good levels of the Omega-3s. The Omega-3 three profile of grass fed red meat is very similar to what you would find in salmon. Obviously, fish is great, so while fish like salmon or sardines are great as well, the reason I like the red meat is it’s something that most people enjoy eating. And as well as the Omega-3s, we’re getting the iron, and iron is a co-factor for making serotonin and making GABA, and it’s needed for energy and so many other functions in the body.

It’s also got zinc, and zinc is a common deficiency, way more common than we realize. And when you are anxious, you may have high copper level, and low zinc level. So getting those zinc levels up will push the copper down, and that can help with your anxiety, as well.

We also had a long discussion on serotonin and tryptophan/5-HTP:

…we often associate serotonin with depression. And a lot of people don’t realize that it’s very closely tied to anxiety, as well. So we’ve got two types of anxiety when it comes to the brain chemicals. One is the low-serotonin type, and this is the anxiety in the head, where you’ve got the ruminating thoughts, and the busy mind, and the negative self-talk, and just this monkey mind that you can’t switch off — this worry, and sort of reprocessing things. And then we have the low-GABA kind of anxiety, where it’s in your physical body and you’re feeling stiff and tense, and you can feel it in your body, and you may feel it in your gut….

I have people do a questionnaire, and depending on how you score on that questionnaire, that’s a clue as to whether serotonin may be a factor. So all of those symptoms I’ve just mentioned, you would rate yourself on a scale of one to ten. And then I use individual, targeted amino acids. So it’s a supplement, and the other things that obviously have an impact are food, and diet, and everything we just talked about. Getting exercise, getting outside in the light, all of those are factors.

But for quick, immediate results, and pretty profound results – people just say to me, “Could this really be happening so quickly?” that’s how quickly we get results, you know, within 30 seconds to two minutes they’re getting results – is to use these individual amino acids as supplements. And the reason they’re called “targeted” is because it’s targeted to your unique needs. Like when you do the questionnaire and it says, yes, you need some serotonin support, and then you would use either tryptophan or 5-HTP as a supplement. And again, targeted, because you need it, but also targeted to your unique biochemistry.

There’s a standard starting dose for tryptophan, which is 500 mg, while 5-HTP is 50 mg.

Be sure to tune into the interview with Debbie Hampton. She is the survivor of an acquired brain injury (from a pill overdose when trying to commit suicide) and the author of the upcoming book, Sex, Suicide, and Serotonin. Her story and resilience is inspiring! Here is Debbie’s wonderful answer to Erin’s question: “What advice would you give to someone who feels like it’s too late to do what they want to do? I’m already so deep in, there’s no way that I could possibly have the life that I wanted or do the work that I really wanted to do.”

debbie-hampton

It’s never too late. And those limitations, you’re putting on yourself. Those limitations are in your mind. If you think you can’t, and you think it’s too late, then it is. You’ve got to change your mind first and if your mind thinks you can, you’re halfway there.

My advice would be to start small … I’m not big on long-term plans. I’m big on a long-term bigger goal. But what you’ve got to do is you’ve got to take a little step in the right direction towards that goal, and when you get there, you look around and you say, “Okay, what is my next best step?” And when you get to that next step, there may be opportunities that you can see that you couldn’t even see back here.

So you’ve got to take it one step at a time and get there and assess your opportunities. And then figure out the next best step, and then get there and figure out the next one. And it may be a zigzag path, and you may even have to go back sometimes, regress, but as long as you just keep moving forward and keep positive momentum and positive thoughts and be your own cheerleader, and encourager, and supporter— be your own friend—that is the most important thing.

I could not agree more – there is an answer, you can do whatever you set out to do and just take baby steps!

You can register for the Brain Summit here:
http://www.brainsummit.com?orid=45505&opid=12

Chronic Lyme Disease Summit – anxiety, pyroluria & more

March 21, 2016 By Trudy Scott 6 Comments

The Chronic Lyme Disease Summit runs from April 4th to 11th so I’m sharing some additional information for you.

The response to this summit, hosted by Dr. Jay Davidson, is out of this world already. Lyme disease is much more talked about than most realize and more people are affected by Lyme disease each year than breast cancer!

Many people with chronic Lyme disease have chronic anxiety too and the focus of my interview is how to use targeted individual amino acids GABA and tryptophan to top up low levels of GABA and serotonin while the Lyme is being addressed.

This gives Lyme sufferers resolution from much of the anxiety (if not all) right away and they don’t need to resort to meds like benzodiazepines or anti-depressants (like the women in the study below). There is also a big connection between Lyme disease and pyroluria and I cover this too.

Here is one study that shows that Lyme-anxiety is very real and that panic attacks may actually be trigged by the Lyme disease:

A paper published in the Journal of Psychiatric Practice in 2000: Panic attacks may reveal previously unsuspected chronic disseminated lyme disease

describes the histories of three patients with panic-like episodes that turned out to be related to underlying, previously unsuspected tick-borne diseases.

Each woman experienced symptoms that are not usual in panic disorder but are typical of neurological Lyme disease, including exquisite sensitivity to light, touch, and sounds, joint pain often in combination with cognitive changes including mental fogginess and loss of recent memory, and some degree of bizarre, shifting, and often excruciating neurological pain. Because these symptoms are atypical of primary panic disorder, they were very helpful in alerting the clinician to suspect an underlying physical illness.

In each case, the results of testing revealed positive hallmarks of disseminated Lyme and other tick-borne diseases [ including Lyme borreliosis caused by the spirochete, Borrelia burgdorferi, babesiosis, and ehrlichiosis.] Since beginning treatment with intensive doses of appropriate antimicrobial medications for their tick-borne infections, all three patients have become free of panic attacks.

Treatment of their infections by a specialist in Lyme disease allowed one of the women to discontinue anti-anxiety medication completely and another to reduce the dose of medication to occasional use only. The third patient is no longer anxious but her depression is resolving more slowly despite the ongoing use of an antidepressant. Two of the patients have also needed ongoing medication for pain and other symptoms of late-stage, neurological Lyme disease

One of my favorite presentations at the 2015 IMMH/Integrative Medicine for Mental Health conference was Dr. Suruchi Chandra’s Neuropsychiatric Lyme Disease talk. She shared that:

Lyme disease is one of the fastest growing infectious diseases in the United States. It can remain dormant for years and then later mimic a number of psychiatric illnesses, including anxiety disorders, mood disturbances, psychosis, and autism-like behaviors. It can be further complicated by the presence of co-infections.

Tune in to the summit to hear more about Lyme and anxiety and the amino acids GABA and tryptophan (and the Lyme-pyroluria connection).

(Please note: I’m not a Lyme disease expert – people seek me out for help with their anxiety and many of them also happen to have Lyme disease. The information we covered in the interview is very powerful for anxiety whether or not Lyme disease is a factor.)

Here are a selection of the many excellent Lyme interviews you’ll hear:

Dr. Jay Davidson, DC, PScD: Heavy Metal Detox and Lyme Disease
Connie Strasheim: Lyme Disease and Cancer
Jack Tips, PhD, CCN: The Gut Microbiome and Lyme disease
Shayne Morris, PhD: Biofilm, Bugs and Bacteriophage
Bradley Bush, ND: A Lab Test that Actually Works for Detecting Lyme Disease

When you register you get access to 3 talks right away – mine is one of the 3 talks! You can register here:
https://qt247.isrefer.com/go/LYME16reg/trudyscottcn

Tryptophan 500mg or Tryptophan Complete (by Lidtke)?

February 19, 2016 By Trudy Scott 134 Comments

tryptogold-lidke — Lidtke Tryptophan 500mg and Lidtke Tryptophan Complete (credit: Lidtke)

If you’ve been following me and have read my book The Antianxiety Food Solution and heard me speak at conferences and on summits, you know I have been an avid fan of the Lidtke tryptophan 500mg for years and years because of the quality and because it works SO well for my anxious clients. The Lidtke brand is the ONLY tryptophan I recommend (and I’m not paid to say this) for boosting serotonin levels. You can find it and the other amino acids I use on the supplements blog.

This week I had a great conversation with Ron Sturtz, Owner and product formulator of the products at Lidtke Technologies. We discussed tryptophan in general and concerns about it not going down the serotonin pathway and instead converting to quinolinic acid.

We talked extensively about the Lidtke Tryptophan Complete and why they include vitamin C, niacinaminde, P5P (the active form of vitamin B6), curcumin, lysine, magnesium glycinate, magnesium taurinate and folate (from lemon peel) in the product. As a result of that discussion I now want to learn more about the Lidtke Tryptophan Complete product for you and for my clients.

I’ll be sharing more information with links to the research as to why these ingredients are important in the serotonin pathway but here is the short version: with these ingredients and co-factors less tryptophan is reportedly needed and there is less chance of it going down the wrong pathway to produce neurotoxic quinolinic acid instead of going down the pathway to make serotonin. We obviously want the latter to happen.

I’ve also decided I want to interview Ron on the next Anxiety Summit. The biochemistry is too important not to share. Hearing him say “we are fanatical about safety!” makes me even more of a fan of this company and their products!

Anyway, according to Ron, you should need less of the Lidtke Tryptophan Complete. He shared that 500mg Lidtke Tryptophan is approximately equivalent to 350mg Lidtke Tryptophan Complete, since it has all the co-factors.

I asked for feedback in some Facebook groups I host and got this:

I’ve used the Tryptophan Complete product and actually like it a lot better than the 500mg version. The Tryptophan Complete gave a much deeper state of relaxation and a way more solid sleep than the 500 mg version. I thought I would try the latter [the 500mg] and although it is good, once it is done, I’m going to go back to the Lidke Tryptophan Complete. For me, it seems that the addition of the other ingredients really worked well for my body chemistry, leaving me feeling grounded, focused and well rested. 🙂

With the Tryptophan Complete she needed just 1 tablet (350mg) an hour before bed and with the Tryptophan 500 mg, she took 2 tabs (1000mg) an hour before bed.

My concerns right now would be individual reactions to any or all the other ingredients, since we all have very individualized needs. Someone did share this on one of my Facebook posts:

Can’t do the p5p! Makes me agitated.

I’m not yet sure what my final recommendations will be but these are my initial thoughts (which may be revised in the future):

I like to have my clients do a trial of the amino acids so they can find the ideal dose for their needs and right now I still feel this would still be the best approach to take – using 500mg tryptophan. Once you have figured out you do well with tryptophan-only product and have your dose, then consider reducing it slightly after about 2-3 weeks and adding in additional Tryptophan Complete.
The other option is this: if you don’t get the expected results with Tryptophan 500mg, then try the Tryptophan Complete. You may need the other ingredients for it to work well for you.
Don’t use the Tryptophan Complete if you know you react to any of the other ingredients
If you do better with higher doses of tryptophan don’t use more than the recommended 3x Tryptophan Complete because you’ll end up with too much of the other ingredients. Rather make up the difference with extra capsules of the 500mg Tryptophan

So for now, since I’m in learning mode/discovery mode I’d love your feedback.

I’d love to hear if you’ve used the Lidtke Tryptophan Complete product (personally or with clients/patients)? And what you’ve observed? Better or worse?

Have you also tried the Lidtke 500mg tryptophan in the past and noticed any difference when using the Lidtke Tryptophan Complete?

And how much of each did you find you needed?

So is it Tryptophan 500mg or Tryptophan Complete or a combination for you?