tension

GABA for easing physical anxiety and tension: some questions and answers

April 2, 2021 By Trudy Scott 68 Comments

GABA is an amino acid used as a supplement to ease low GABA levels. With low GABA you’ll experience physical-tension and stiff-and-tense-muscles type of anxiety, panic attacks and insomnia. You may feel the need to self-medicate to calm down, often with alcohol but sometimes with carbs and sugary foods. GABA also helps with muscle spasms and provides pain relief when muscles are tight.

When I share my GABA blogs on Facebook I receive so many great questions (some basic questions and some more complex). Today I’m going to share some of these and my answers so you can get the benefits too.

Let’s start with the basic questions about using GABA.

Amanda asks:

What time of the day is best to take GABA?

The best time is 1 to 4 x a day, depending on your symptoms, between meals and always away from protein so it doesn’t compete for absorption with the other amino acids.

Brian asks:

What dose do you recommend starting at?

I have clients start with 125mg and go up from there based on how they respond i.e. are they getting symptom resolution.

Based on the above 2 questions it’s clear that Amanda and Brian are new to using the amino acid GABA. If you are new to using GAB and the other amino acids (and other anxiety nutrition solutions like gluten/sugar/caffeine removal, blood sugar control, gut health, pyroluria etc.) my book “The Antianxiety Food Solution” is a great place to start.

I don’t cover specific brands in my book because brand formulations change and come and go so this is a great question from Olivia who asks:

Which brand would you recommend? thank you

My favorite is Source Naturals GABA Calm but since it’s been in short supply during the pandemic I list many other GABA options here. I’ve updated the main supplements blog with these additional GABA options too.

Now for some of the more advanced questions:

Salome asks:

I’m super sensitive to supplements (Histamine Intolerance / MCAS / Multiple chemical sensitivity). Are there any potential reactions from taking GABA that you know of?

As far as I know there are none (clinically or in the research) but, as always, the best is to do a trial. For clients who are very sensitive we start super low and may use 1/8 to 1/4 of the starting dose of 125mg GABA, and increase from there if there are no adverse effects.

Dena asks:

Does GABA help the same way Xanax does? I only take 0.5mg Xanax a few times a week when I really need it but if GABA works I’d like to try it but worry it won’t help like Xanax does. It calms me down and makes me feel normal

Many of my clients report back that GABA works just like Xanax used to work for them. But do keep in mind it’s important to work with your prescribing doctor and that the benzodiazepine taper should be very very slow. And it’s important to be aware that for some folks tapering can be very challenging (more on that here).

Boyd asks:

In New Zealand GABA is classed as a prohibited Class B drug so what can be used as an alternative for anxiety?

Taurine or theanine are good options if GABA is not available and mail order is not an option. Glutamine can be calming for some folks who are able to convert some of it to GABA. For others it can be too stimulating if it converts to glutamate. Addressing gut health and using precursors like magnesium, zinc and vitamin B6 are also key but this takes longer to see results.

Debbie asks:

Can u take GABA if taking a very low dose SSRI (sertraline). I’ve had to start it because I couldn’t find a GABA product when I needed it.

GABA is safe to take with an SSRI (antidepressant) but this should always be discussed with the prescribing doctor. Also, keep in mind that Sertraline works on serotonin so GABA may not be the best solution and tryptophan or 5-HTP may be. Looking at the low GABA and low serotonin symptoms and doing a trial is the best way to figure this out.

Cornina asks:

What could be used instead of Ativan for travel anxiety?

I would trial GABA if the anxiety is more physical with neck tension and butterflies in the stomach or tummy pain. I would trial tryptophan or 5-HTP if it’s mental like imagining-the- worst or if you have a phobia about flying or you are worrying and obsessing. Ideally you would want to build up levels before travelling and also use the amino acids as needed while traveling. Keep in mind that both GABA and serotonin support may be needed.

Kelly asks:

Is 4,000 mg of Now GABA too much for a person to take a day. This person is 86 years old.

This dose of 4,000mg GABA is high so I’d want to know if she is seeing benefits (and what benefits) and having any adverse reactions. I’d also want to know what product and how it’s being used (swallowed or opened on to the tongue).

I asked the above and Kelly shared this additional information:

Yes, it lessens the anxiety but also makes her very sleepy. She doesn’t take that many mg every day. She just swallows it.

When the GABA capsules are opened less can be used. Also, taking it at night helps improve sleep and avoids the sleepiness in the day and the anxiety-relief benefits often carry over to the next day too. We commonly experiment with different timings and dosing to find what works best for the client as there is no one-size fits all.

Rhonda asks:

Which would be best for a truck driver that drives all night – GABA or 5-HTP?

For someone who drives all night and wants to sleep in the day I would want to know why he or she can’t sleep (assuming it’s related to disrupted circadian rhythm). If it’s physical tension then I’d trial GABA, and if it’s worry and over-thinking then I’d trial 5-HTP or tryptophan for serotonin support. Often a combination is helpful, Research shows the sleep promoting effects of combined GABA and 5-HTP for some folks.

We appreciate these folks for asking questions and allowing me to share here on the blog.

As always, it’s not only the low GABA we need to address. GABA offers quick relief but we must always do a full functional workup looking at diet, nutritional deficiencies, digestion, all hormones, toxins and infections (and so on) so we can address all possible root causes.

Have these GABA questions and answers been helpful? Have you seen benefits from using GABA and do you have questions?

Feel free to post your questions and feedback in the comments below.

And join us on Facebook – TrudyScottAntianxietyFoodSolution – to read and ask questions there too.

GABA Calm is in short supply – what other GABA products are there for easing anxiety?

January 22, 2021 By Trudy Scott 82 Comments

Sheila contacted me via the blog asking about Source Naturals GABA Calm ~ I am from Brussels/Belgium. I cannot find the Source Naturals GABA Calm sublingual anymore. The one you recommend. I’ve been recommending this for years to clients since I read your book “The Antianxiety Food Solution.” I already contacted Source Naturals a few times but no response. Do you know why they have stopped selling this in Europe?

After doing some checking around and contacting Source Naturals it seems there is a world-wide shortage of Source Naturals GABA Calm 125mg lozenges. When I reached out to them I was told it’s indefinite (with no reason why) and to check back at the end of January. Two other people were told it would be available mid-January and mid-February so the messages are mixed.

Today I’m sharing some other GABA product options until GABA Calm comes back or in case it doesn’t or if there is another shortage in the future. It’s such a pity since it is so effective for so many folks as you can see in these blogs:

I also posted this message on Facebook to let my community there know and to find out what they were using instead.

This is some of the feedback I received:

Mary ~ Oh my goodness! I just found it in my local Vitamin Shoppe tonight! There was one bottle left.
Diana ~I noticed. My son uses this, I’m a little worried.

I shared that there are other products that will hopefully work as well and asked everyone who was using something else: Do you use it opened onto the tongue or swallowed? And if you’ve used Source Naturals GABA Calm in the past how does it compare for you?

A number of people said they like Thorne pharmaGABA capsules, someone said she like Now GABA Powder and a few people like Natural Factors pharmaGABA chewables:

Tara ~ I’ve only used Thorne PharmaGABA because of how it’s derived [fermented]. I just swallow the capsule and I’m immediately calm within 5-15 mins. I was previously prescribed a benzo & this is much better. 100mg is all I take when I feel a panic attack coming on. I’ve been thru a few years of absolute hell of benzo withdrawal coming off of my klonopin prescription. The GABA feels almost the exact same as the benzo except the benzo would actually cause rebound panic attacks (I didn’t realize it at the time) & the GABA does not.
Jane ~I use Now Foods GABA powder. A little under the tongue works well.I have found both effective. Powder good for rapid effect at home (1/4 teaspoon as needed). GABA Calm good to take out with you.
Meesh ~ I use the Natural Factors pharmaGABA (100mg) and it works great. I use it in combo with L-theanine 250mg (which also contains 20mg of magnesium)… and the combination is magic

I’ve updated the supplements blog with the above products and a few additional similar products so you have many options to select from based on your unique needs and taste preferences, and what’s available at the time:

Thorne PharmaGABA-100: the label says Gamma-Aminobutyric Acid (GABA) 100 mg but it also states that the product uses Pharma Foods International’s Gamma-Aminobutyric Acid (PharmaGABA®). This is also pleasant-tasting when opened on to the tongue and is most effective when used this way.
Thorne PharmaGABA-250: as above but contains 250mg of PharmaGABA®. This is also pleasant-tasting when opened on to the tongue and is most effective when used this way.
Designs for Health PharmaGABA Chewables: gamma-amino butyric acid (pharmaGABA) 200 mg in 2 chewable tablets. It’s quick-acting and convenient like GABA-Calm because it’s chewable. This does contain xylitol, natural flavors, stevia and some other ingredients so taste may be a factor and xylitol can cause gas, bloating and diarrhea when too much is consumed.
Natural Factors PharmaGABA: gamma-amino butyric acid (pharmaGABA) 200 mg in 2 chewable tablets. It’s quick-acting and convenient like GABA-Calm because it’s chewable. However it also contains organic cane sugar and natural fruit flavors so it’s a little too candy-like for my preference, especially if you have low GABA-related sugar cravings. Also 2 chewable tablets – 4g of carbs which is almost 1 teaspoon of sugar!
[January 22, 2021: I’ve included this as a stand-by option for occasional use until Source Naturals GABA Calm is readily available again or if Designs for Health PharmaGABA Chewables are not available.]
Now Foods GABA Powder: 1/4 Level Teaspoon (500mg). This is pleasant-tasting when opened on to the tongue and is most effective when used this way. The only challenge with powder like this is making sure you don’t use too much by mistake. And it’s especially challenging when you only need 100mg.
Quicksilver Scientific Liposomal GABA with L-Theanine: 2ml (4 Pumps) provides (Gamma Amino Butyric Acid) 240mg, L-Theanine 100mg and Phosphatidylcholine 120mg (from purified sunflower seed lecithin). It does contain ethanol so would not be suitable for alcoholics or young children.

I do want to add that Nutritional Fundamentals for Health GABA-T SAP is still a firm favorite of mine: gamma-Aminobutyric acid (GABA) 300 mg, l-Theanine 150 mg. This is pleasant-tasting when opened on to the tongue and works very well when GABA Calm can’t be used (because of the tyrosine or taste or sugar alcohols). It is also often used with GABA Calm – like GABA Calm in the day and GABA-T SAP at night or some combination. I find best results when it is used opened on to the tongue and it offers a feeling of calm focus. It could easily be used as a substitute for GABA Calm in the short-term.

In case you’re new to GABA you can read more about it here: GABA for the physical-tension and stiff-and-tense-muscles type of anxiety.

Is Source Naturals GABA Calm a favorite of yours? And how has it helped you? What have you found works as well – for physical anxiety, tension, insomnia, pain, sugar cravings, muscle spasms – when it’s not available?

If you’ve used a GABA product in capsules, do you use it opened onto the tongue or swallowed? And if you’ve used Source Naturals GABA Calm in the past how does it compare for you?

If you’re a practitioner do you use GABA Calm and/or other GABA products?

Please do share in the comments below and let me know if you found this helpful or if you have questions. And thanks for the questions and contributions so far!

GABA is the answer after 40 years of a lump-in-the-throat sensation, nervousness and muscle tension at work

November 20, 2020 By Trudy Scott 18 Comments

Earlier this year, I published a blog post on the sensation of having a lump in the throat when you feel anxious. It’s called globus pharyngeus which is defined as “the painless sensation of a lump in the throat and may be described as a foreign body sensation, a tightening or choking feeling.”

Globus means globe/sphere and it can actually feel like you have a golf-ball sized object in your throat. It’s very uncomfortable and quite terrifying outside of the anxiety that is often the trigger. I share my lump-in-the-throat story and my success with GABA in this blog: Anxiety and globus pharyngeus (lump in the throat): GABA to the rescue?

Pam recently shared her wonderful success with GABA on the above blog, after having dealt with what she calls “her throat thing” for 40 years!

I have dealt with this throat thing since I was a teenager. I’m now 57. It was only when I saw what you wrote about how yours came back after a scary airplane incident that I made the connection that GABA could help me. I saw that in the summer of 2019, so I spent about 40 years dealing with this until I found the GABA answer!

Mine comes up when speaking in front of others, such as work meetings, or even just one-on-one work discussions, and it was getting consistently worse. I would be swallowing constantly and trying to talk. Absolutely awful. Of course everyone could see it happening.

GABA solved this for me, and I can’t even describe how grateful I am!

How wonderful are these results! I am so happy for her and thanked her for coming back and sharing in the comments. I also asked some follow-up questions so I can continue to learn and so I can share so you get to learn too:

How much GABA helps and how do you take it (when you know you’ll be in this situation or a few times a day to get your levels up)?
Did you ever use a prescribed medication or were recommended something?
Have you seen any other benefits from using GABA – improved sleep, reduced anxiety in other situations, reduced cravings?
Have you made other changes too – like dietary changes such as gluten/sugar/caffeine/alcohol removal?

She shared this about timing and how GABA helps with anxiety-related physical/muscle tension and nervousness:

I take GABA Calm … one upon waking, 1 mid-morning, and 1 mid- afternoon. I take an extra one right at the time of a meeting.

That is the only change I made. I’ve never been on any prescription medication.

Other than the specific throat issue, I notice I’m generally less physically tense, with muscles not getting so knotted up in my face, scalp, neck, shoulders, and back, which is wonderful.

I work at a computer job, which causes lots of muscle tension, but I feel that anxiety-related muscle tension has reduced.

I notice that my muscles have less of that “immediate tightness” upon seeing someone whom I’m nervous to interact with.

This timing and dosage of GABA Calm is typically what I use with clients and what works so it was great to hear that it’s working for her. I was also so pleased to hear the anxiety-related muscle tension and nervousness has reduced too. This is also to be expected.

I did remind her to keep in mind that the amino acids are intended for short-term use. This could be a few weeks up to 6-12 months depending on each person. While using the GABA, I have my clients start to address all the dietary changes, gut health, nutritional deficiencies (zinc and B6 are needed to make neurotransmitters and key with pyroluria), toxin exposure (like BPA, phthalates, pesticides, fluoride etc), infections (like Lyme and co-infections, parasites, PANDAS/PANS) etc. and everything else that may be causing low GABA levels (as we covered in The Anxiety Summit 6).

Vagus nerve support is also key. I cover what I did for my vagus nerve in this blog that Pam referred to: Vagus nerve rehab with GABA, breathing, humming, gargling and key nutrients

Globus pharyngeus or this sensation of the-lump-in-the throat is way more common than most people realize and mainstream medicine seldom has a solution. Medications that are commonly prescribed for globus pharyngeus are benzodiazepines, antidepressants/SSRIs and sometimes PPIs/proton pump inhibitors. Cognitive behavior therapy has some success in some instances but it’s always best to get to the root cause of low GABA and address that with the amino acid GABA. And then figure out why GABA is low and address that too.

If you’re new to the amino acids here is a quick summary about GABA: low levels of GABA, a calming neurotransmitter can lead to anxiety, fears and panic attacks. With low GABA, the anxiety is a physical kind of anxiety with muscle tension or muscle spasms. I propose that low GABA may be one possible root cause of globus pharyngeus.

I appreciate Pam for sharing her story and I’m sharing it here in order to give you practical solutions and hope. If she can find a solution to her 40-year the-lump-in-the throat and physical tension issues then anything is possible.

Please also share your lump-in-the-throat story and what has helped you. Or if you’re a practitioner, do share how you have helped your clients/patients who experienced this sensation.

Feel free to post your questions here too.

Trichotillomania: NAC, GABA, tryptophan, inositol and zinc?

January 5, 2018 By Trudy Scott 33 Comments

This recent paper reports on a case study with NAC – Trichotillomania: a good response to treatment with N-acetylcysteine

Trichotillomania is considered a behavioral disorder and is characterized by the recurring habit of pulling one’s hair, resulting in secondary alopecia. It affects 1% of the adult population, and 2 to 4.4% of psychiatric patients meet the diagnostic criteria. It can occur at any age and is more prevalent in adolescents and females. Its occurrence in childhood is not uncommon and tends to have a more favorable clinical course.

The scalp, eyebrows and eyelashes are the most commonly affected sites. Glutamate modulating agents, such as N-acetylcysteine, have been shown to be a promising treatment. N-acetylcysteine acts by reducing oxidative stress and normalizing glutaminergic transmission. In this paper, we report a case of trichotillomania with an excellent response to N-acetylcysteine.

In this case report an 11 year-old male student had been pulling his hair out for 6 months. He had a relationship problem with this father and also suffered from asthma and dermatitis. He was started on NAC:

Treatment with N-acetylcysteine was initiated (1200 mg/day for three months). The patient’s outlook improved dramatically, but complete remission was not achieved. We chose to increase the dosage to 1800 mg/day, which resulted in almost complete regrowth.

[From: Trichotillomania: a good response to treatment with N-acetylcysteine]

In this paper from 2009, N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study, it is reported that

Fifty individuals with trichotillomania (45 women and 5 men) received 1200-2400 mg/day of N-acetylcysteine or placebo over a 12-week period.
56% percent of patients experienced “much or very much improved” hair-pulling symptoms with N-acetylcysteine use compared with 16% using the placebo, and the improvements were first noted after 9 weeks of supplementation.
Those in the N-acetylcysteine group did not experience any adverse events.

As you can see, the results with NAC are excellent but it can take 9 weeks and more before results are seen. For this reason, I would always also assess for low serotonin and low GABA and do trials of tryptophan or 5-HTP for low serotonin and GABA for low GABA. With any compulsive and obsessive behaviors I always consider inositol too and we may add this once the ideal dose of tryptophan has been found.

What is my rationale for recommending GABA, tryptophan, 5-HTP and/or inositol?

Since NAC works on reducing oxidative stress and normalizing glutaminergic transmission, GABA may help too and will certainly help to ease any physical anxiety that is being experienced
“Recommended first-line therapy for this psychiatric condition is administration of SSRIs” even though their efficacy is not yet proven in children – for this reason I’d recommend tryptophan or 5-HTP
Also “according to the psychiatric definition, these patients pull their hair because the act is gratifying and reduces tension, anger, depression and anxiety” (these are all signs of low serotonin and another reason to consider tryptophan or 5-HTP)
Because they offer relief right away, within 1-5 minutes

A complete nutritional and functional medicine work-up would be part of the plan too – to address the asthma and dermatitis (in the first paper above) and any other symptoms the person is experiencing and may be a contributing factor.

I’d expect the 56% of improved patients (in the second study above) to go to a much higher percent with all of the above approaches.

When I shared these papers on Facebook I was asked this question from someone who pulls out her eyelashes:

I pull my mascara off what is left of my eyelashes every night. I try my hardest not to do it but I find it impossible once I’ve touched my lashes. I’m about to start taking GABA and I was thinking about taking NAC. Would it be a bad idea to take both these amino acids?

This is my feedback: I always like to do one thing at a time and (as mentioned above) I would do the amino acid questionnaire and a trial of tryptophan and GABA first if the scores are high, and then look at adding NAC. If there are still some obsessive tendencies I would consider adding inositol. I am not aware of any issues with using all of these nutrients at once.

Someone else asked this:

Wouldn’t you deal with the psychological cause of it too – at the same time?

My response: Yes absolutely – if there is a psychological cause. But be aware that sometimes it’s purely nutritional or biochemical.

Another person shared that she only exhibits these behaviors when she’s stressed. Of course, the nutrients mentioned above, plus dietary changes, adrenal support, improving gut health and everything that I educate about, are important for reducing stress.

I also received some success stories. Here is one of them:

I’ve struggled with trichotillomania and dermatillomania (skin picking) for years and years. I underwent hypnosis that was extremely effective. When I added in zinc (after reading your book) the urge is almost completely gone. Thank you!

Keep in mind that zinc is a co-factor for making serotonin and GABA, is important for overall adrenal support and stress reduction, is needed for glutathione production and works as an antioxidant. I’d actually love to see these studies repeated with zinc alone.

And then I received this message from someone else:

I’m messaging you my answer about NAC because it’s slightly embarrassing I’ve always had terrible acne and always have picked at it obsessively and could not stop until I was given some supplements for PCOS which happened to contain NAC. To my surprise I lost the compulsion to pick at my skin, something I had never thought possible!

How wonderful for both of them! I always appreciate feedback like this and have to say nothing is too embarrassing to share (especially if it helps someone else).

Have you used NAC with success – with trichotillomania or dermatillomania (skin-picking) or even nail-biting? Or some other compulsive behavior?

What about GABA or inositol or tryptophan or zinc (or something else) for the same purpose and/or for additional emotional and stress-reducing support?

Magnolia officinalis and Phellodendron amurense (Relora®) lowers cortisol and reduces stress and anxiety

November 11, 2016 By Trudy Scott 19 Comments

magnolia

I recently blogged about the Seriphos reformulation: Seriphos has been reformulated – what do I use to lower high cortisol? and promised to share additional products that could provide similar benefits. When someone in my community shared that she uses Relora® with success I started to look at the research and I am very encouraged.

This 2013 study: Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects

assessed salivary cortisol exposure and psychological mood state in 56 subjects (35 men and 21 women) screened for moderate stress and supplemented with a standardized/patented MP [Magnolia bark extract and Phellodendron bark extract] combination (Relora®, Next Pharmaceuticals) or placebo for 4 weeks.

After 4 weeks of supplementation (500 mg /day, with 250 mg at breakfast and 250mg at dinner) these were the results seen in the Relora® group (compared to the placebo group):

salivary cortisol exposure was significantly lower (18%)
lower overall stress (11%)
lower tension (13%)
less depression (20%)
less anger (42%)
less fatigue (31%),
less confusion (27%)
and significantly better mood state parameters (11%) and vigor (18%)

relora-effect-chart (table from Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects)

Each of the components in Relora® have been shown to be beneficial for controlling stress and anxiety, with the combination proving to be even more effective:

Extracts of Magnolia officinalis bark and its active constituent, honokiol, have been studied in animal models with comparable anxiolytic activity to diazepam (a benzodiazepine anxiolytic used to treat anxiety), but without associated side effects such as sedation.

Berberine, a constituent of the Phellodendron extract, has also demonstrated a significant anxiolytic effect in rodent stress studies.

The combination of magnolia plus phellodendron appears to be even more effective in controlling stress/anxiety compared to either herb used separately.

The study concluded that:

daily supplementation with a combination of Magnolia bark extract and Phellodendron bark extract (Relora®) reduces cortisol exposure and perceived daily stress, while improving a variety of mood state parameters, including lower fatigue and higher vigor.

These results suggest an effective natural approach to modulating the detrimental health effects of chronic stress in moderately stressed adults.

An added bonus is that there were no adverse events or side effects reported.

I’d like to note that the study does report that it was funded by the manufacturer of Relora® (Next Pharmaceuticals) and conducted by SupplementWatch.

A related study, also funded by the manufacturer: Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial indicated that

Relora may offer some relief for premenopausal women experiencing mild transitory anxiety.

In this study, the participants used 250mg Relora® 3 times daily for 6 weeks and although mild anxiety was reduced, no changes were observed in cortisol levels. Clearly more research is needed and as with any nutrient, there will be the fact that you may benefit from it and someone else may not.

I’m encouraged enough by the research to begin recommending this product for high cortisol and the anxiety caused by the high cortisol. This will of course be done in conjunction with all the other approaches I use: real whole food, quality animal protein, eat to control blood sugar, no gluten/sugar/caffeine, addressing gut health, using GABA/tryptophan and the other amino acids as needed and addressing low levels of zinc, vitamin B6, vitamin D, iron if necessary. Additional adrenal support would include extra vitamin C and pantothenic acid, a B complex and possibly rhodiola.

Have you used Relora® with success either personally or with clients/patients? Has it lowered salivary cortisol levels? Has it helped with stress and anxiety?

If you had been using Seriphos to help lower high cortisol and reduce stress and anxiety, and decide to use Relora® please let us know how effective it is for you.

Update November 18, 2016: I emailed Interplexus asking if they will be bringing back the original Seriphos formula and received this message from them:

Yes, the information is correct we will be returning the previous formula of Seriphos and are expecting to have it late November, unfortunately we do not have a completion date as of yet so the estimated time frame is not a guarantee. It will be the same formula as before and we will also manufacture a Phosphatidylserine standalone product in the future. If you have further questions or concerns feel free to contact, and you’re also welcome to check on the status of Seriphos periodically.

Update January 20, 2017: Seriphos Original Formula is back and you can read more about it here

Tryptophan for PMS: premenstrual dysphoria, mood swings, tension, and irritability

July 1, 2016 By Trudy Scott 57 Comments

In a study published in 1999, A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria, tryptophan was found to reduce symptoms of PMS when used in the luteal phase or second half of the cycle (i.e. after ovulation):

37 patients with premenstrual dysphoric disorder were treated with L-tryptophan 6 g per day, and 34 were given placebo. The treatments were administered under double-blind conditions for 17 days, from the time of ovulation to the third day of menstruation, during three consecutive menstrual cycles.

They looked at dysphoria, which is defined as a state of unease or generalized dissatisfaction with life, plus mood swings, tension (and anxiety), and irritability and they found a 34.5% reduction of symptoms with tryptophan compared to 10.4% with placebo.

The paper concludes:

that these results suggest that increasing serotonin synthesis during the late luteal phase of the menstrual cycle has a beneficial effect in patients with premenstrual dysphoric disorder.

Let me share what I see with the women with PMS that I work with:

This is very typical when I’m working with someone with PMS and anxiety and other mood symptoms. It typically takes 2 to 3 cycles for an amino acid like tryptophan to have an impact on PMS itself. But it does typically start to work right away on the less severe anxiety and mood symptoms that may also be a factor during the rest of the month.
I don’t start with 6g per day of the tryptophan but rather have each person do the amino acid questionnaire, review the precautions and do a trial of tryptophan, increasing as needed to find the optimal amount for their needs (you can read more about this here on anxiety and the amino acid overview
We often find that adding GABA helps too, as this supports progesterone production
Many anxious women I work with also have pyroluria or signs of low zinc and low vitamin B6 and adding these nutrients, together with evening primrose oil, provide additional hormonal support (and help with the social anxiety).
Other factors to consider with PMS: low total cholesterol (as cholesterol is needed to make hormones), gluten issues, adrenal function and blood sugar control, gut health and the microbiome, and liver support
And finally, we can’t forget diet and need to switch to eating a real whole foods diet free from sugar, gluten and caffeine. Coffee and chocolate in the second half of the cycle can be especially problematic for many women

Together with the tryptophan and the above approaches (if needed as we are all so different), it’s not unreasonable to get the reduction of symptoms from 34.5% (as seen with the tryptophan) down to 100%. It breaks my heart when I hear women think they have to live with PMS symptoms when they don’t have to!

Have you used tryptophan for PMS? Do you take it all month or just in the 2nd half of your cycle? What about other changes that have helped: GABA or liver support or quitting caffeine? Or something else? Please share.