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The liver/thyroid/serotonin and liver/GABA/progesterone connections: The Anxiety Summit 6

September 30, 2020 By Trudy Scott 10 Comments

liver thyroid serotonin

Dr. Ameet Aggarwal is one of my guest experts on The Anxiety Summit 6: Toxins/Meds/Infections!
and our topic is Liver Function and Bile: Anxiety, Detox, the Gut and Hormones. Here is some of what we cover in our interview:  

  • The liver/anxiety connections: thyroid/serotonin, microbiome and GABA/progesterone
  • Foods and nutrients like NAC, triphala, turmeric, taurine and lycopodium
  • Gilbert’s syndrome and schizophrenia; misophonia; family constellations therapy; giving and endorphins

and much more.

ameet aggarwal

We discuss a number of the mechanisms as to why poor liver function affects your mood. There is the liver/thyroid/serotonin connection, and the liver/GABA/progesterone connection.

In the discussion on the liver/thyroid/serotonin connection and anxiety, Dr. Ameet shares from this paper – The Relationship between the thyroid gland and the liver (paraphrased as I don’t yet have transcripts):

  • Thyroxine and tri‐iodothyronine are essential for normal organ growth, development and function
  • These hormones regulate the basal metabolic rate of all cells, including hepatocytes, and thereby modulate hepatic [liver] function
  • The liver in turn metabolizes the thyroid hormones and regulates their systemic endocrine effects.
  • Thyroid dysfunction may perturb liver function
  • Liver disease modulates thyroid hormone metabolism.

The catecholamine and thyroid interrelationship is well recognized but less is known about the serotonin and the thyroid. Dr. Ameet shares the synergy between the thyroid hormones, serotonin and mood:

  • animal studies shows that the thyroid economy has a modulating impact on the brain serotonin system
  • studies in hypothyroid patients have shown that thyroid replacement therapy improves serotonin production

In summary, if we have compromised liver function and/or low thyroid function this may impact serotonin levels and lead to increased anxiety.

Here is a snippet from our discussion on the liver/GABA/progesterone and anxiety:

  • We often think about mental health as being neurotransmitters alone but it also depends on hormones. Progesterone affects how GABA works in the brain.
  • GABA is your anti-anxiety neurotransmitter but it requires progesterone to work well in your brain and your liver metabolizes all your hormones through phase 1 and phase 2 detoxification
  • If your liver is compromised then you’re likely to have lower progesterone levels and estrogen dominance.
  • With low progesterone GABA won’t work as well as well in the brain, leading to anxiety and insomnia.

Again, if we have compromised liver function this may impact progesterone levels, having an effect on how GABA works and causing increased anxiety.

If you recall, I shared this GABA/progesterone snippet a few weeks ago before the site was ready and now it’s ready for you to register.

This interview is one of the registration gifts so you can listen to it right away as soon as you register (there will also be a complimentary transcript made available as soon as it’s completed.)

ameet interview

Here is a little about the summit… as you know, anxiety can be related to your daily life experiences BUT it can also be triggered by:

  • foods you eat and what you drink (like wheat, oxalates, alcohol and more)
  • environmental toxins (like lead, plastics, fragrances, insecticides, fluoride and more)
  • many types of medications (like the birth control pill, acne medication, fluoroquinolone antibiotics and more) and/or
  • chronic infections (like Lyme disease, PANDAS, parasites, candida and more).

Once you identify the root causes and understand anxiety’s mechanisms you can support the liver/gallbladder, detox, address infections, implement targeted and supportive solutions, and get relief!

WHY ATTEND?

This is my 6th Anxiety Summit, featuring all new topics and the latest research related to anxiety and toxins, medications and infections.

I’ve also experienced many of these health challenges myself – lead and mercury toxicity, gluten issues and candida – and I’m currently dealing with chronic Lyme disease and dietary oxalate issues. You’ll hear some of my healing journey and my solutions in a few interviews too.

anxiety summit 6

WHAT SETS THIS ONLINE EVENT APART?

What sets this apart from other events on toxins and infections is being able to make the many connections to GABA (the main calming neurotransmitter) and serotonin (a happy and calming neurotransmitter) AND how to use  the amino acids GABA and tryptophan to ease your anxiety right away while you are dealing with the other underlying root causes – which take longer to address.

You will see this woven into each of the expert interviews (just like this one with Dr. Schaffner) and also addressed in detail in my 3 interviews where I do a deep dive into specific applications.

For example, in my toxins interview, I share how GABA reverses fluoride-induced anxiety and hypothyroidism, and how tryptophan and vitamin C ease anxiety symptoms associated with lead toxicity  (I’ll be sharing more about this in the future so stay tuned….)

Over the course of the next 6 weeks you’ll be seeing frequent emails from me with snippets and highlights from various interviews – like this one. I do hope you continue to enjoy them and get excited about the summit! Please do share if you know someone who has anxiety!

It’s been wonderful to get all the emails saying how excited you are and seeing so many of you signing up. These last few months have been full-time on research and interviews and I’ll shortly get to share it all with you!

You’ve heard me say the Anxiety Summit has been called “a bouquet of hope!”  My wish for you is that this summit is your bouquet of hope!

I hope you’ll join me and these incredible speakers, be enlightened and find YOUR solutions!

Here’s to no more anxiety and you feeling on top of the world again!

Register here

 

If you’re already familiar with some of this information and practice some of this already please share how it’s helped you. That way we can all learn.

If you’d like to ask a question, please post in the comments below.

I’d also love to hear from you once you’ve listened to this interview. Please do come back and comment about some of the highlights of this interview and what changes you plan to make.

Even if you already receive my newsletters and signed up some time ago to be notified about the upcoming Anxiety Summit 6, you will still need to register at the new link here, because Health Talks Online is doing the production and backend work for me.

If you don’t register you won’t get access to the daily summit emails with all the interviews.

You will however, continue to get these emails from me.

This is my 6th Anxiety Summit and it is all new content!

The content is research-based and practical, and is geared to anxious individuals who are health-savvy and to practitioners who work with anxious individuals.

If you are totally new to functional medicine and nutritional solutions for anxiety, you will still learn so much so just take in what you can and know you’ll get all this eventually.

Filed Under: The Anxiety Summit 6 Tagged With: Ameet Aggarwal, anxiety, GABA, liver, progesterone, serotonin, The Anxiety Summit 6, thyroid

Kate Spade: suicide, hormonal imbalance, antidepressants as a trigger and the stigma of mental health

June 15, 2018 By Trudy Scott 32 Comments

Photo by Paul Keleher (originally posted to Flickr as kate spade) [CC BY 2.0], via Wikimedia Commons
Kate Spade, a well-known American fashion icon and handbag designer, died by suicide last week at the age of 55. I’m always torn in situations like this…just share the news story with my sympathies in order to respect the family or use this as an opportunity to learn from and prevent others from suffering the same fate. This time I’m doing the latter – with the risk of appearing insensitive – because there are red flags here and I feel so strongly that we all need to learn from this in order to move mental health forward. I’m hoping her husband and family would approve.

In the announcement about Kate Spade’s suicide in the New York Times, Mr. Spade said:

that though his wife had suffered from anxiety at points during their relationship and marriage, her serious bouts of depression only began about six years ago, at the age of 49.

Kate suffered from depression and anxiety for many years. She was actively seeking help and working closely with her doctors to treat her disease, one that takes far too many lives. We were in touch with her the night before and she sounded happy. There was no indication and no warning that she would do this. It was a complete shock. And it clearly wasn’t her. There were personal demons she was battling.

My heart goes out to Kate Spade’s husband, young daughter and loved ones. Her suicide is just so sad but as I said I have a fair bit to say about this….

 

Hormone imbalance triggering anxiety and depression?

According to the reports, Kate’s “serious bouts of depression only began about six years ago, at the age of 49, but she had suffered “from depression and anxiety for many years”.

Perimenopause and menopause is a classic time for women to experience worsening anxiety and depression and can be driven by fluctuating hormones, especially low estrogen. In this study, Depression and the menopause: why antidepressants are not enough? the authors share that

Postmenopausal depression is more severe, has a more insidious course, is more resistant to conventional antidepressants in comparison with premenopausal women and has better outcomes when antidepressants are combined with HT (hormone therapy).

Addressing hormone imbalance as one possible root cause can eliminate the anxiety and depression. Some of my favorite resources for hormone balance are these books: The Hormone Secret and Cooking for Hormone Balance.

 

Low levels of neurotransmitters like serotonin, catecholamines and GABA?

Directly connected to hormonal imbalance is brain chemistry imbalance. Addressing low levels of neurotransmitters like serotonin, the catecholamines and GABA provide results quickly when they are used in a targeted way based on individual needs:

  • Low serotonin is an issue when estrogen levels are declining and the amino acid tryptophan can have profound benefits if low serotonin is one of the root causes, leading to depression, worry, fear, overwhelm and sleep issues.
  • Low catecholamines can cause the “I just want to say in bed” depression and low motivation, together with fatigue and poor focus. The amino acid tyrosine can help to eliminate some of this and also provides thyroid support.  Poor thyroid health can also be a root cause of depression.
  • We see low GABA levels when progesterone is low and if this is one of the root causes, it can result in increased physical anxiety and insomnia. The amino acid GABA, opened on to the tongue, can provide calming results within minutes.

I can totally relate to the hormonal aspect as I suffered from PMS for years and my anxiety issues and panic attacks started in my late 30s and I had a really low spell as I was going through menopause.  Both GABA and tryptophan turned things around very quickly for me as they do for my clients.

 

The role of diet and nutritional psychiatry?

There is so much new science behind the role of a real foods traditional diet for alleviating both depression and anxiety. The SMILES study, published by Prof Felice Jacka early 2017, was the first randomized controlled diet depression study and ONE THIRD of the dietary intervention group saw improvements in their depression symptoms.  This was just diet alone and switching from processed and junk food to real food with no specific dietary restrictions.

There is also much clinical evidence supporting how diet can have an impact. Holly, suffered from with severe depression and anxiety changed her diet and shared this with me:

Over the course of a year and a half, I was given 10 different psychiatric diagnoses and cycled through 10 different medications. I discovered the healing power of diet completely by accident, and it changed my life. I now live with no diagnoses and no symptoms.

I started with the Whole30 (strict paleo), then went paleo, dabbled with a ketogenic approach, and now I eat a modified paleo diet, with some rice and goat dairy.

This has been termed nutritional psychiatry and you can read more diet-depression and diet-anxiety success stories here.

Keep in mind that your prescribing psychiatrist may not yet be on board with this or up to date on the newest research. Just last week someone told me what happened when they discussed nutritional psychiatry with their doctor and showed them my book The Antianxiety Food Solution (my Amazon link). He said: “Good luck with that!”

 

Could the antidepressant medication have triggered her suicide?

The statement from Kate’s husband says “She was actively seeking help for depression and anxiety over the last 5 years, seeing a doctor on a regular basis and taking medication for both depression and anxiety.”  Could the antidepressant medication have triggered her suicide or played some part?

We will never know with Kate but this is always my first thought when I learn of a suicide and when we hear of homicides in the news. One of my colleagues shared this when her suicide was first announced: “I was wondering if she was under psych care and what role meds might have played in this tragedy.”

This paper is one of many papers reporting similar antidepressant suicide and violence risks, and concludes that:

Antidepressants double the occurrence of events in adult healthy volunteers that can lead to suicide and violence

Kelly Brogan MD – Holistic Psychiatrist​ no longer prescribes psychiatric medications because we don’t know who will experience this side-effect. She writes this about a Swedish study and antidepressants and increased suicides

As antidepressant prescriptions increased 270% over 15 years, suicide rates also increased. Strikingly, more than half of the young women who committed suicide (52%) were prescribed antidepressants within a year of committing suicide. And antidepressants were detected in 41% of the women who committed suicide, showing that they were under the influence of antidepressants at the time of death. 

 

What if you are taking an antidepressant and seeing benefits?

When I posted some of this on Facebook earlier in the week someone who is on an antidepressant and benefiting shared her frustration that we are blaming suicide on medications.

There are many who do benefit but there are two issues I have:

  1. Even if someone is doing well on an antidepressant, benzodiazepine or other psychiatric medication I feel we need informed consent about the side-effects and training for the individual and family on what to look out for as things can change. The can occur when meds are changed, doses are increased or decreased, new meds are added, one or more are stopped abruptly or too quickly (called discontinuation syndrome). Many doctors also need to be educated and to acknowledge that suicide and homicide are very real side-effects of these meds.
  2. We don’t know who will be adversely impacted, which is why consent/knowledge about this is so important.

When we rent ski equipment or go bungee jumping we sign an informed consent form, acknowledging the possible risks of death. Why is this not happening with these medications? I just want individuals to be going into this with eyes wide-open so they don’t say “why didn’t anyone tell us this?”

If someone is currently seeing benefits from antidepressants (or benzodiazepines) I make sure they know ALL the risks and encourage them to continue to look for root the causes and address these (never stopping medications abruptly and never without the prescribing doctor’s permission).

There are many possible biological or biomedical or metabolic causes of depression and anxiety and many of these can play a factor in suicide.  Here is a list of just some of them:

  • gluten sensitivity and celiac disease
  • low B12, low B6, low omega3s, low zinc
  • the anti-malaria drug mefloquine (has been associated with acts of violence and suicide)
  • toxoplasma gondii
  • fluoroquinolone antibiotics
  • many common drugs may be contributing to depression (over 200 including acid reflux meds, blood pressure meds, birth control pill)

My concern is that none of these – the medications or poor diet and nutritional deficiencies – are ever discussed when someone does commit suicide or goes on a violent or homicidal rampage.

 

The stigma of mental health and the fear of seeking help

There are reports that “Kate Spade felt unable to seek help or discuss her mental health because she feared this might damage the brand she created.”  This is a huge issue and if it was true for her or if anyone with a mental health condition feels like this, this has to change!

As Dr. Mark Hyman MD​ said this when I interviewed him last year before the launch of his Broken Brain docu-series

I began to realize that the body was driving a lot of this brain dysfunction, and that if you fix the body, a lot of the brain disorders would get better, that it wasn’t a primarily a mental problem, but it was a physical problem.

Our interview and full transcript is here and we cover the gamut in 12 minutes: the gut and microbiome, nutritional deficiencies, food sensitivities, heavy metals, other environmental toxins and medications.

We don’t hide the fact that we have a broken leg so why do we have to hide it when we have a broken brain? If we can start to acknowledge that mental health issues so often have this physical aspect (and often it’s 100% physical) then hopefully we can end this crazy stigma.

And even if there is also trauma or lifestyle factors that make someone depressed or anxious – so be it. Stop the stigma and shame. Why do we have to put on a brave face and pretend all is well. It has to stop so people can ask for help.

Last but not least, I feel we need to offer practical nutritional psychiatry resources to the family who have been traumatized by the loss of a loved one to suicide.  We know the amino acids and B vitamins help individuals recover from psychological stress after a natural disaster and these same nutrients can help the family in the midst of their sorrow.

I am aware it’s a very delicate subject and I’m sure this will rub some people the wrong way but I believe we all need to be talking about this and not tip-toeing around it.

I really feel this all needed to be said today. I hope this helps you or a loved one.

Rest in peace Kate Spade.

Filed Under: Amino Acids, Depression, Nutritional Psychiatry Tagged With: antidepressant, anxiety, depression, estrogen, fear, GABA, hormone imbalance, Kate Spade, mental health, progesterone, root causes, serotonin, SSRI, stigma, suicide

The Anxiety Summit – Foods to balance your hormones and ease anxiety

May 11, 2015 By Trudy Scott 77 Comments

 

Magdalena Wszelaki, founder of Hormones Balance, is interviewed by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

Foods to balance your hormones and ease anxiety (part 1)

  • Magdalena’s own journey with Graves’ disease, Hashimoto’s disease, adrenal fatigue, estrogen dominance and anxiety
  • How hormonal imbalances can cause anxiety: low progesterone, low/high estrogen
  • How over and underactive thyroid can cause anxiety
  • The adrenals and anxiety and depression

Foods to balance your hormones and ease anxiety (part 2)

  • How to test for hormonal imbalances
  • The foundation to all hormonal health being: healthy gut, healthy blood sugar levels and optimal liver health
  • Foods that support the production of the different hormones
  • Seed rotation for balancing estrogen and progesterone
  • The role of coffee in liver health, hormone metabolism and anxiety

 

In part  1 we discussed this 2015 paper: Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods.

Here we review the evidence from animal experiments and human studies reporting interactions between sex hormones and the dominant neurotransmitters, such as serotonin, dopamine, GABA and glutamate

The brain represents an important target for estrogen and progesterone effects.

major shifts in sex hormone levels seem to be paralleled by the incidence rates of mood disorders such as unipolar depression

A subgroup of women suffers from clinical level of premenstrual mood changes called premenstrual dysphoric disorder (PMDD)… core symptoms include anxiety, irritability and depressed mood

Estrogen has been reported to have potent serotonin-modulating properties

progesterone and its neuroactive metabolites (allopregnanolone, pregnanolone) seem to facilitate GABAergic transmission

To summarize, neurotransmitter systems do not work in isolation and sex hormones act on multiple sites, highly intertwined with serotonin, dopamine, GABA and glutamate.

Magdalena shared these low estrogen symptoms:

  • Forgetfulness
  • Incontinence
  • Skin elasticity problems
  • Loss of muscle strength
  • Feeling really blah
  • Osteoporosis/osteopenia
  • Warm flashes and/or night sweats

Magdalena shared these low progesterone symptoms:

  • Tender breasts
  • PMS
  • Irregular periods
  • Puffiness and water retention
  • Mood swings and anger
  • Anxiety and sleep issues
  • Problems falling pregnant
 
In part 2:
 
Magdalena shared how the foundation of hormone balance is a healthy gut and talked about food intolerances, the microbiome, bone broths and quality animal protein.
 
I loved the discussion on using seed rotation for hormonal balancing: flax seeds and pumpkin seeds for the first half of your cycle and sesame and sunflower seeds for the second  half of your cycle/luteal phase (the cracker recipes are in the gift download – see below). 
 
Coffee does affect our hormones and here is a great guest blog post by Magdalena: 12 Ways Coffee Impacts Your Hormones 
If you had to give up either coffee or the internet for 2 weeks, which one would you choose? How about either coffee or sex for 2 weeks? If you’d rather relinquish anything to keep your coffee, you’d be on par with the majority of the people around you.
Be sure to check it out and try out her delicious Roasted Chicory Root Latte recipe.

I shared my recipe: Carob Cinnamon Delight instead of coffee – a calming hot beverage and mentioned rooibos tea how it’s A Functional Food in the Management of Stress (an interview from a prior anxiety summit)

Magdalena mentioned the EWG/Environmental Working Group’s Skin Deep site for checking your cosmetics – simply enter the name of the product in the search area.

We also mentioned Annmarie Gianni Skin Care, which is a natural skin care line made with organic ingredients that you can trust – and that actually work. This is the best and most natural skin-care line I have come across – anywhere! It’s organic, uses absolutely zero toxic ingredients and features gorgeous essential oils! You can try your Annmarie Gianni Skin Care sample kit here. 

 

Magdalena’s gift: How to Rebalance Your Hormones with Food and Recipes

magdalena gift image

 

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here: www.theAnxietySummit.com 

Missed this interview or can’t listen live? Or want this and the other great interviews for your learning library? Purchase the MP3s or MP3s + transcripts and listen when it suits you.

You can find your purchasing options here: Anxiety Summit Season 1, Anxiety Summit Season 2, and Anxiety Summit Season 3.

Filed Under: Antianxiety, Fertility and Pregnancy, Hormone, The Anxiety Summit 3, Thyroid health Tagged With: cortisol, estrogen, food, GABA, hormones, Hormones Balance, Magdalena Wszelaki, progesterone, serotonin, the anxiety summit, Trudy Scott

The Hormone Secret and progesterone for anxiety

March 18, 2015 By Trudy Scott 64 Comments

Dr Tami Meraglia, MD, is the author of  The Hormone Secret. I had an advance review copy and read it on the plane coming back from San Diego and it’s fabulous!

Read on below for a wonderful sample snippet from the book:

Did you know that you have a natural anti-anxiety hormone?

Women have a hormone that is produced in the ovaries and the adrenal glands that is like Valium bathing the female mind.  It helps reduce anxiety and is known as the peaceful hormone.  It also helps us sleep soundly through the entire night.

What is this amazing hormone?  Progesterone.

Progesterone acts on the gamma amino butyric (GABA) receptors in the brain (the same receptors sleeping pills, anti-anxiety medication and even alcohols act upon), producing a calming effect.  GABA is the primary inhibitory transmitter in the brain.  If you wake between 2am and 4 am wide awake, you likely have a progesterone deficiency.

Progesterone also affects the elasticity of our skin, memory, is anti-inflammatory, is a natural diuretic and helps normalize blood sugar.  It also stimulates that cells that make new bone called osteoblasts.

Unfortunately progesterone leaves our bodies first and leaves us quickly.  You can have a low progesterone level as early as your late 20’s!  Many women think that their increased irritability, loss of enjoyment of life and trouble sleeping if from their 24/7 lifestyle but it is likely more often due to a progesterone deficiency

Here are 7 common symptoms associated with low progesterone:

  1. Anxiety
  2. Waking at night
  3. Fibrocystic breasts
  4. PMS
  5. Bone loss
  6. Low libido
  7. Infertility or irregular periods.

Here are 3 simple and natural things you can do to help your own body produce more progesterone:

  • Vitamin C.   A dose of 750-1000 mg has been shown in studies to raise progesterone in women.
  • Selenium.  200-400 mcg/day was shown to boost production of progesterone in an Italian study.
  • The spices turmeric, thyme and oregano are also useful for raising progesterone.  Use in cooking whenever you can.

Topical progesterone is also available over-the-counter.

If you find that it takes a bit more energy to keep your cool or that you are no longer sleeping through the night I encourage you to look to progesterone as a way to help.

I love Dr. Tami’s famous quote: “Remember, fine is a four-letter word.  You deserve to feel FABULOUS!”   I could not agree more – we all deserve to feel our absolute best all the time!

I do want to mention that we do differ in our food recommendations. I’m a Paleo eater myself and am recommending this more and more to my clients.   But I absolutely LOVE the hormone information in this book!  Just wait until you read about testosterone too – yes! And natural ways to boost your own production! And/or how to use small amounts for women!  It’s very different from what you typically hear.

 

Filed Under: Anxiety and panic, Books, Hormone Tagged With: anxiety, progesterone, Tami Meraglia, the hormone secret

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