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The liver/thyroid/serotonin and liver/GABA/progesterone connections: The Anxiety Summit 6

September 30, 2020 By Trudy Scott 10 Comments

liver thyroid serotonin

Dr. Ameet Aggarwal is one of my guest experts on The Anxiety Summit 6: Toxins/Meds/Infections!
and our topic is Liver Function and Bile: Anxiety, Detox, the Gut and Hormones. Here is some of what we cover in our interview:  

  • The liver/anxiety connections: thyroid/serotonin, microbiome and GABA/progesterone
  • Foods and nutrients like NAC, triphala, turmeric, taurine and lycopodium
  • Gilbert’s syndrome and schizophrenia; misophonia; family constellations therapy; giving and endorphins

and much more.

ameet aggarwal

We discuss a number of the mechanisms as to why poor liver function affects your mood. There is the liver/thyroid/serotonin connection, and the liver/GABA/progesterone connection.

In the discussion on the liver/thyroid/serotonin connection and anxiety, Dr. Ameet shares from this paper – The Relationship between the thyroid gland and the liver (paraphrased as I don’t yet have transcripts):

  • Thyroxine and tri‐iodothyronine are essential for normal organ growth, development and function
  • These hormones regulate the basal metabolic rate of all cells, including hepatocytes, and thereby modulate hepatic [liver] function
  • The liver in turn metabolizes the thyroid hormones and regulates their systemic endocrine effects.
  • Thyroid dysfunction may perturb liver function
  • Liver disease modulates thyroid hormone metabolism.

The catecholamine and thyroid interrelationship is well recognized but less is known about the serotonin and the thyroid. Dr. Ameet shares the synergy between the thyroid hormones, serotonin and mood:

  • animal studies shows that the thyroid economy has a modulating impact on the brain serotonin system
  • studies in hypothyroid patients have shown that thyroid replacement therapy improves serotonin production

In summary, if we have compromised liver function and/or low thyroid function this may impact serotonin levels and lead to increased anxiety.

Here is a snippet from our discussion on the liver/GABA/progesterone and anxiety:

  • We often think about mental health as being neurotransmitters alone but it also depends on hormones. Progesterone affects how GABA works in the brain.
  • GABA is your anti-anxiety neurotransmitter but it requires progesterone to work well in your brain and your liver metabolizes all your hormones through phase 1 and phase 2 detoxification
  • If your liver is compromised then you’re likely to have lower progesterone levels and estrogen dominance.
  • With low progesterone GABA won’t work as well as well in the brain, leading to anxiety and insomnia.

Again, if we have compromised liver function this may impact progesterone levels, having an effect on how GABA works and causing increased anxiety.

If you recall, I shared this GABA/progesterone snippet a few weeks ago before the site was ready and now it’s ready for you to register.

This interview is one of the registration gifts so you can listen to it right away as soon as you register (there will also be a complimentary transcript made available as soon as it’s completed.)

ameet interview

Here is a little about the summit… as you know, anxiety can be related to your daily life experiences BUT it can also be triggered by:

  • foods you eat and what you drink (like wheat, oxalates, alcohol and more)
  • environmental toxins (like lead, plastics, fragrances, insecticides, fluoride and more)
  • many types of medications (like the birth control pill, acne medication, fluoroquinolone antibiotics and more) and/or
  • chronic infections (like Lyme disease, PANDAS, parasites, candida and more).

Once you identify the root causes and understand anxiety’s mechanisms you can support the liver/gallbladder, detox, address infections, implement targeted and supportive solutions, and get relief!

WHY ATTEND?

This is my 6th Anxiety Summit, featuring all new topics and the latest research related to anxiety and toxins, medications and infections.

I’ve also experienced many of these health challenges myself – lead and mercury toxicity, gluten issues and candida – and I’m currently dealing with chronic Lyme disease and dietary oxalate issues. You’ll hear some of my healing journey and my solutions in a few interviews too.

anxiety summit 6

WHAT SETS THIS ONLINE EVENT APART?

What sets this apart from other events on toxins and infections is being able to make the many connections to GABA (the main calming neurotransmitter) and serotonin (a happy and calming neurotransmitter) AND how to use  the amino acids GABA and tryptophan to ease your anxiety right away while you are dealing with the other underlying root causes – which take longer to address.

You will see this woven into each of the expert interviews (just like this one with Dr. Schaffner) and also addressed in detail in my 3 interviews where I do a deep dive into specific applications.

For example, in my toxins interview, I share how GABA reverses fluoride-induced anxiety and hypothyroidism, and how tryptophan and vitamin C ease anxiety symptoms associated with lead toxicity  (I’ll be sharing more about this in the future so stay tuned….)

Over the course of the next 6 weeks you’ll be seeing frequent emails from me with snippets and highlights from various interviews – like this one. I do hope you continue to enjoy them and get excited about the summit! Please do share if you know someone who has anxiety!

It’s been wonderful to get all the emails saying how excited you are and seeing so many of you signing up. These last few months have been full-time on research and interviews and I’ll shortly get to share it all with you!

You’ve heard me say the Anxiety Summit has been called “a bouquet of hope!”  My wish for you is that this summit is your bouquet of hope!

I hope you’ll join me and these incredible speakers, be enlightened and find YOUR solutions!

Here’s to no more anxiety and you feeling on top of the world again!

Register here

 

If you’re already familiar with some of this information and practice some of this already please share how it’s helped you. That way we can all learn.

If you’d like to ask a question, please post in the comments below.

I’d also love to hear from you once you’ve listened to this interview. Please do come back and comment about some of the highlights of this interview and what changes you plan to make.

Even if you already receive my newsletters and signed up some time ago to be notified about the upcoming Anxiety Summit 6, you will still need to register at the new link here, because Health Talks Online is doing the production and backend work for me.

If you don’t register you won’t get access to the daily summit emails with all the interviews.

You will however, continue to get these emails from me.

This is my 6th Anxiety Summit and it is all new content!

The content is research-based and practical, and is geared to anxious individuals who are health-savvy and to practitioners who work with anxious individuals.

If you are totally new to functional medicine and nutritional solutions for anxiety, you will still learn so much so just take in what you can and know you’ll get all this eventually.

Additional Anxiety Resources
Click on each image to learn more

Filed Under: Anxiety Summit 6 Tagged With: Ameet Aggarwal, anxiety, GABA, liver, progesterone, serotonin, The Anxiety Summit 6, thyroid

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About Trudy Scott

Food Mood Expert Trudy Scott is a certified nutritionist on a mission to educate and empower anxious individuals worldwide about natural solutions for anxiety, stress and emotional eating.

Trudy is the author of The Antianxiety Food Solution: How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood and End Cravings and host of The Anxiety Summit now in its 4th season and called a “bouquet of hope.”

Trudy is passionate about sharing the powerful food mood connection because she experienced the results first-hand, finding complete resolution of her anxiety and panic attacks.

Reader Interactions

Comments

  1. AvatarVivien says

    October 1, 2020 at 6:56 am

    Hi Trudy,

    I’ve listened to Dr. Ameet’s interview with great interest.
    I’m told I have a problem with Phase 2 liver detox and wonder whether people with Pyrroluria are particularly susceptible to this.
    Some seem to think highly of the benefits of grapefruit for bile production, but I’ve also heard it should be avoided where Phase 2 is sluggish. (It’s usually mentioned to be avoided with medication, isn’t it.)

    Many thanks,
    Vivien

    Reply
    • AvatarTrudy Scott says

      October 1, 2020 at 6:36 pm

      Vivien
      That’s a good question – I don’t know if people with pyroluria are more susceptible to problems with phase 2 liver detox and now I’m curious to dig deeper. I can say that if you do have problems with phase 2 liver detox it could be considered a stress to the body and stress (mental and physical and biochemical) is what makes pyroluria symptoms worse.

      I’ve not heard about grapefruit for bile production and recommend the approaches Dr. Ameet covers in his interview – bitter foods, bitters, taurine and even triphala

      And correct about grapefruit juice and medications. This paper is a useful review “Grapefruit and certain other citrus fruits represent examples of foods generally considered to be healthful, but with the potential for a pharmacokinetic interaction causing greatly enhanced oral drug bioavailability.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589309/

      Reply
      • AvatarVivien says

        October 23, 2020 at 3:22 pm

        Hi again Trudy,
        In the interview with Anne Louise Gittleman in the previous Summit 5, Anne was very enthusiastic about grapefruit, so opinions obviously vary. It seemed to be one of her favourite bitters, helping with bile, etc. I suppose we’re all very individual, aren’t we.
        Many thanks for your reply. Vivien

      • AvatarTrudy Scott says

        October 27, 2020 at 10:23 pm

        Vivien
        Thanks for the reminder – I had forgotten that! and yes we are all individual and some practitioner have their favorites

      • AvatarVivien says

        October 29, 2020 at 7:54 am

        Many thanks for that link, Trudy.
        The thing is, I have breast cancer. I was unable to take Pharma drugs (which have a warning about not eating grapefruit).
        I have been taking a natural aromatase inhibitor called Myomin. There was nothing on the label to warn about grapefruit, so seeing how Anne Louise Gittleman had nothing but praise for grapefruit for the liver, I began to eat it regularly. It was only several months later that I realised it had done me harm. Needless to say, my anxiety levels have gone through the roof, apart from physical symptoms advancing considerably. I notice in Dr. Michael Murray’s book he warns against grapefruit in connection with liver detox.
        I realise you won’t want to let this comment be viewed by others, but I felt I needed to tell you.

        Vivien

      • AvatarVivien says

        November 3, 2020 at 1:33 am

        Dear Trudy,
        Dr. Murray mentions that he has great respect for you. In view of my comment on grapefruit (and my reference to Dr. Murray’s advice on this subject), I felt that I wanted to say how I too have great respect for you, having followed your summits and website for a number of years.
        Vivien

  2. AvatarPaula Bartholomy says

    October 1, 2020 at 12:01 pm

    So glad to see Dr Ameet on this summit, what a dear man he is! This summit looks terrific so far Trudy, my best wishes for success

    Reply
    • AvatarTrudy Scott says

      October 1, 2020 at 5:33 pm

      Hi Paula
      I agree, he is much-loved! I’m so pleased to have had the opportunity to inteview him again and share more about the liver/hormones and anxiety connections!

      Thanks for your kind words about the summit – it’s a labor of love!

      Hope you are doing well and are out of harms ways with the fires!

      Reply
  3. Avataryasmin says

    October 19, 2020 at 5:17 pm

    Trudy,

    Thank you so much again! I was wondering if GABA lowers Estogen dominance? I saw that low Progestrone can lower GABA production. If I take GABA would that help if my Estrogen seems a bitter higher. At this point I only noticed some skin dark spots ( blotchy) on cheek area and my OBGYN did a test that indicated slighty higher Estrogen. I am 42 with Hypothyroid taking Armourthroid.
    Would appreciate your ideas!!

    Reply
    • AvatarTrudy Scott says

      October 27, 2020 at 10:24 pm

      Yasmin
      Raising GABA balances out the high estrogen: low GABA ratio. With dark skin spots I’d focus on liver support

      Reply

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