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GABA

Metal-on-metal hip replacement and cobalt toxicity: anxious, tearful, lowered self-esteem, social withdrawal and poor sleep

By Trudy Scott 8 Comments

I’m always on the look-out for out-of-the-box root causes for anxiety, insomnia and low mood and the role of targeted amino acids like GABA, tryptophan and tyrosine in easing symptoms clients and boy was I surprised to learn about the connection between metal-on-metal hip replacements and mental health symptoms.

I first learned about this in the new Netflix documentary called The Bleeding Edge which is an “eye-opening look at the fast-growing medical device industry” and “reveals how the rush to innovate can lead to devastating consequences for patients.”

With metal-on-metal hip replacements it’s the cobalt and chromium in the metal-on-metal hip replacements that are causing toxicity in many individuals. In the Guardian article The Bleeding Edge: behind the terrifying new Netflix documentary we hear about Stephen Tower, an orthopedic doctor who shared his story in the documentary:

He had developed a tremor and was having a hard time thinking when he decided to scrawl all over the walls and ceiling of a hotel room during a medical conference, eventually using soap as ink.

Tower, his friends and family knew he was in the throes of mental health crisis, but no one was sure why. So, Tower studied himself until he found the answer in a blood and urine sample: his levels of cobalt, a metal used in rechargeable batteries, were more than a hundred times higher than normal.

Tower thought it might be related to his metal-on-metal hip replacement and had it redone. On the operating table, his surgeon found metal sludge seeping from the device before it was removed.

Dr. Tower shares that within a month of having his hip replacement redone his recovery was remarkable – he could think again, and his psychiatric symptoms resolved.

The sad thing is that he actually admits that he would never have believed this could be possible without having had experienced it himself. We see this all too often in the medical profession.

But he is now enlightened and of course he’s passionate about sharing what he experienced and has started documenting similar adverse experiences in his patients. He says the EPA and FDA should be studying this and reporting it and so they should be.

I was curious to find out how serious an issue this was and how long it’s been an issue because surely we’d be hearing more about it.

A paper published in 2017: Neuropsychiatric symptoms following metal-on-metal implant failure with cobalt and chromium toxicity reports depression and short term memory problems, as well as “disorientation in place, problems with tests of concentration and word finding difficulties.”

The paper includes feedback from some of the study participants. This is what two of them shared about their mood, sleep and anxiety post-hip replacement:

Ms. X … persistent anxieties about the need for future surgery and a feeling she must always be cautious about protecting her hip, tearfulness, lability of mood, lowered self-esteem – “I used to be very active and now I feel a mess”, guilt about being a burden on her husband, a fear about the effects of ions on her body and poor concentration.

Mrs. Z … complained of poor sleep with early morning wakening, low mood and emotional lability, social withdrawal, poor appetite, forgetfulness and a tendency to repeat herself reported by relatives, her frustration at being unable to do day to day activities such as cleaning, she felt she was a burden to relatives, and complained of anhedonia [or an inability to feel pleasure in normally pleasurable activities]. She was disorientated in person, was unable to perform serial sevens and was able to register, but not able to retain any elements of a new name and address on cognitive testing.

The study authors state that “in order preserve neurocognitive function implant removal conceivably should be as soon as possible after toxicity is detected.”

They admit it’s a small sample and that some of the depression and anxiety may be typical after a surgery HOWEVER once I looked at how long metal-on-metal cobalt toxicity has been an issue I feel we really need to take this very very seriously. Here are just a few of the studies from 2017 going back to 2011:

Cobalt can be responsible for local toxicity (including metallosis, hypersensitivity reaction, and benign tumor) or systemic toxicity (including cardiomyopathy, polycythemia, hypothyroidism, and neurological disorders).

  • Systemic toxicity related to metal hip prostheses (published 2014) This systematic review states toxicity is rare but reported cases of cardiotoxicity, thyroid toxicity, peripheral neuropathy, hearing loss, cognitive decline and visual impairment.

Prosthetic hip-associated cobalt toxicity (PHACT) is gaining recognition due to the use of metal-on-metal total hip replacements

And then we have this study reporting toxicity issues as far back as 1999:

Our findings suggest that in total hip replacements using metal-metal pairings, metal ions of the alloys are released. This release may lead to significantly elevated metal concentrations in biological fluids. Long-term studies are needed to determine the risk of metal-metal implants as a potential cause of cobalt and chromium toxicity.

You may wonder how this toxicity problem has been ignored and swept under the rug for so long. If you watch the documentary, you’ll soon see that the medical devices industry is far more powerful than the pharmaceutical industry and has its own set of rules for medical device approval. It’s basically the wild west and the FDA is doing nothing about it (even though it is acknowledged to be a problem)!

I’m not suggesting we shouldn’t be doing hip replacements – they are amazing surgical innovations that give many people their mobility and lives back – but instead I suggest we consider the following:

  • Know what you’re getting into before you embark on a major medical procedure
  • Understand that the testing for medical devices is very inadequate
  • Ask questions and get detailed information about the medical device: what materials are being used, how long it’s been around, any known adverse effects etc.
  • Search for information using terms like “horror stories metal-on metal hip replacement” and “law suits metal-on metal replacement”
  • Have a plan in place should you start to notice adverse symptoms after a hip replacement (or other major procedure). You may even want a medical directive in case you become cognitively incapacitated

I have no expertise on what the safest type of hip replacement is and will find an expert for a part 2 of the blog. If you know of someone please do share in the comments.

How do we address the cobalt and chromium toxicity?

  • Tower, the orthopedic doctor in The Bleeding Edge documentary found his symptoms resolved once the metal-on-metal hip replacement was removed. The research seems to support this approach too
  • A 2-person case study supports the use of N-acetyl-cysteine (NAC) for reducing blood levels
  • An in vivo (test tube) study found astaxanthin “mitigated cobalt cytotoxicity … by modulating oxidative stress”

How do we address the anxiety, insomnia and associated mood issues?

I recommend using the above amino acids short-term to ease symptoms before the hip revision surgery is done and for as long afterwards as they are needed. And, as always, base the use of the amino acids on trials per the amino acid questionnaire.

Also, work with a thyroid expert for thyroid support which will also help the mood and cognitive issues. And work with a heart specialist to rule out any damage to the heart.

If you’ve had a metal-on-metal hip replacement in the past and have chronic anxiety or cognitive issues (that started or got worse after the surgery), then I encourage you to look into cobalt toxicity as a possible root cause or contributory root cause.

Please feel free to share your experiences with this surgery – both good and bad – so we can all learn. And if the amino acids have helped ease anxiety and mood symptoms and helped you sleep while going through this.

And do let us know what you think about the Netflix documentary The Bleeding Edge.

Fipronil insecticide: GABA/glutamate and anxiety, aggressive behavior, memory and Alzheimer’s disease in humans?

By Trudy Scott 15 Comments

The insecticide called fipronil has me concerned because there is increasing evidence that it can be toxic to humans and, much to my surprise, I’ve just discovered that the main mechanism of action is by targeting the gamma-aminobutyric acid (GABA) receptor and recent research points to increased anxiety, aggressive behavior, memory problems and even Alzheimer’s disease in animal studies.

Based on a rather surprising conversation I had with someone a few weeks ago (let’s call her Sue), I felt compelled to get more information on fipronil. Before that I was not aware about the specific effects I mention above.

We were in Sue’s front yard and the dog kept sniffing these small white plastic squares in the flower beds. Sue kept pulling the dog away and I asked “why? what are those?” It turns out they were ant-bait devices. Yes, I’m this clueless simply because I’ve never purchased anything like this. I expressed my concerns about toxicity and possible endocrine/hormone effects but didn’t have enough concrete facts, so I went digging through the research. Needless to say I am very concerned with what I found.

What was equally concerning is that Sue had not even considered that it could be harmful. Looking into possible harms was not even on her radar. When pressed, Sue said “it’s only a small amount in each container so I’m sure it’ll be fine” and “the poison is inside the container so none of it will come out – so it’ll be fine.”

This is what went through my mind (which is pretty typical for me – I’m always in questioning mode): What is it and how toxic is it? Does it have impacts on humans and by what mechanism? Could it cause anxiety or increase existing anxiety symptoms? Are there additional concerns about it being in a flower-bed near the front door where you could possibly walk some into the house or breathe it in as you come and go?

Organophosphates and psychological effects

Organophosphates are a commonly used pesticide used on fruits and vegetables and research going as far back as 1994 reports that acute exposure can cause psychological effects because they

act directly on the nervous system by inhibiting the neurotransmitter acetylcholine … [contributing to] … acute psychological and behavioral effects, such as anxiety, depression, and cognitive impairments.

The researchers also suggest that long-term psychological effects of low-level exposure have not been determined satisfactorily.

We hear less about insecticides such as fipronil

We hear less about insecticides such as fipronil and how they work.

According to the National Pesticide Information Center Fipronil is a broad use insecticide that

belongs to the phenylpyrazole chemical family. Fipronil is used to control ants, beetles, cockroaches, fleas, ticks, termites, mole crickets, thrips, rootworms, weevils, and other insects.

Fipronil is used in a wide variety of pesticide products, including granular products for grass, gel baits, spot-on pet care products, liquid termite control products, and products for agriculture.

It can be found in ant-bait and anti-cockroach products as well as Frontline Plus (tick and flea protection) for cats and dogs. You can find a partial list of products here and a fact sheet here.

GABA & glutamate: anxiety, aggressive behavior and neurotoxic effects

Fipronil works to kill insects via the inhibition of glutamate- and GABA-activated chloride channels resulting in uncontrolled neural excitation. It also blocks GABAA receptor function and is typically considered toxic to insects but not humans.

As soon as I read the GABA-glutamate mechanism I started searching for anxiety and neurotoxic connections.

There are no human studies on increased anxiety due to fipronil exposure but research on zebrafish larvae exposed to fipronil at typical environmental levels, finds anxiety-like behavior.   In the paper, A metabolomic study of fipronil for the anxiety-like behavior in zebrafish larvae at environmentally relevant levels, the authors report decreased levels of glycine and serine with higher levels of glutamate saying fipronil may be a potential neurotransmitter disruptor. Here are some of the possible mechanisms they discuss related to this:

  • The decreased metabolite glycine caused by fipronil may contribute to the excitatory swimming performance. Whether the glycinergic reciprocal receptor (GlyR)…inhibitory mechanism is also involved in low level of fipronil [exposure] requires further investigation.
  • Additionally, as one of the most abundant amino acids in microenvironment stress, proline is biosynthetically derived from the amino acid L-glutamine. Low levels of L-proline detected in fipronil-treated group may indicate the accumulation of glutamine. As an excitatory neurotransmitter, high level of glutamine would associate with the excitatory behavior of the fish.

In another study, Prenatal exposure to fipronil disturbs maternal aggressive behavior in rats, the authors suggest fipronil impacts the central nervous system areas that control aggression and increases in maternal aggressive behavior are via impacts on GABA(A) receptors.

This 2016 paper lists a variety of toxic effects to both animals and humans: Fipronil insecticide toxicology: oxidative stress and metabolism:

because of accidental exposure, incorrect use of fipronil or widespread fipronil use leading to the contamination of water and soil, there is increasing evidence that fipronil could cause a variety of toxic effects on animals and humans, such as neurotoxic, hepatotoxic, nephrotoxic, reproductive, and cytotoxic effects

They explore oxidative stress as a possible mechanism as to how fipronil causes these toxic effects.

Does concrete make fipronil more toxic?

One of the questions I asked myself was this: Are there additional concerns about it being in a flower-bed near the front door where you could possibly walk some into the house?

It turns out that this may be a valid concern. In this 2016 paper, Conversion of pesticides to biologically active products on urban hard surfaces, the researchers report that urban landscapes that include concrete can actually convert pesticides to other biologically active and more toxic intermediates, likely caused by the alkalinity and metal oxides in concrete. They report that fipronil:

was quickly transformed to desulfinyl and sulfone derivatives, with the desulfinyl level exceeding that of parent in the runoff water only 1week after treatment. Fipronil derivatives have aquatic toxicity similar or even greater than the parent fipronil.

Impacts on memory and a possible factor in Alzheimer’s disease

This 2016 animal study, Memory impairment due to fipronil pesticide exposure occurs at the GABAA receptor level, in rats concludes that fipronil can

have toxic interactions with the CNS [central nervous system] of mammals and lead to memory impairment by modulating the GABAergic system.

We also have to ask how big a role this insecticide could be playing in Alzheimer’s disease? In a paper published earlier in 2018, Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides, they use the term “Alzheimerogens” when writing about insecticides such as fipronil and the metabolite fipronil sulfone:

Focusing on fipronil, we showed that some of its metabolites, in particular the persistent fipronil sulfone, also favor the production of Aβ42/Aβ43 in both cell-based and cell-free systems.

Fipronil administered orally to mice and rats is known to be metabolized rapidly, mostly to fipronil sulfone, which stably accumulates in adipose tissue and brain.

In conclusion several widely used pyrazole insecticides [such as fipronil] enhance the production of toxic, aggregation prone Aβ42/Aβ43 peptides, suggesting the possible existence of environmental “Alzheimerogens” which may contribute to the initiation and propagation of the amyloidogenic process in sporadic AD.

The paper shares that amyloid-β peptides (Aβs), especially increased production of Aβ42/Aβ43 over Aβ40, represent a characteristic feature of Alzheimer’s disease.

Why wait for long-term human studies?

Hopefully you’re like me and don’t buy ant-bait or roach-bait products.

My bigger concern is the wide-spread use of spot-on pet-care products which contain fipronil, exposing our beloved pets to this toxin and all the humans they come into contact with. Pet-groomers are especially cautioned. And I’d also add a caution for children playing with pets where these flea and tick products are used since “the developing brain is particularly vulnerable to the action of insecticides.”

We don’t know for sure how harmful this insecticide is for humans and it’s not clear what the mechanisms are – GABA-glutamate and/or glycine and/or oxidative stress – but why wait for long-term human studies, especially given that chronic and long-term effects are difficult to investigate and based on what we already know about their effects on Parkinson’s disease, amyotrophic lateral sclerosis, and depression.

I have found enough information to be very concerned and to feel justified in continuing to avoid fipronil. I encourage you to avoid fipronil as well.

This is especially the case if you already suffer from long-term anxiety, insomnia or another chronic health condition as it may be one more possible contributory factor.

Given that fipronil blocks GABAA receptor function, I have to wonder if chronic long-term exposure could play a role in difficulties with benzodiazepine tapering.

If this is old news to you feel free to share with family and friends who may not be as informed as you.

If this is news to you, I hoping this gets you thinking and questioning. I’d love to hear your thoughts, concerns and questions.

Pharma-GABA: study participants with an irrational fear of heights are relaxed and less anxious when crossing a swaying suspension bridge

By Trudy Scott 7 Comments

Based on clinical evidence, we know that gamma-aminobutyric acid (GABA), a calming amino supplement, reduces anxiety. There isn’t as much research on GABA or Pharma-GABA as we’d like to see, so we’ll take small studies that are done on humans.

In a 2006 study, Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans, Pharma-GABA was used to determine if it would increase relaxation and reduce anxiety during the stressful event of crossing a suspension bridge:

Eight healthy volunteers, with no clinical evidence of any illness, (5 males and 3 females) aged 25 to 30 years who had a history of acrophobia [extreme or irrational fear of heights], were recruited.

Subjects crossed … a pedestrian suspended bridge at Nara Prefecture, Japan (Totsu River Bridge) with 54 m height, 300 m length, and 2 m width.

I believe it’s also called the Tanize Suspension bridge and is one of the longest suspension bridges in Japan. You can see pictures of the bridge here and here. They say this: “though quite safe, the swaying motion can be disconcerting, or fun, depending on your perspective.”

If we convert that to feet, it’s 177 feet high, almost 1000 feet long (about 3 times the length of a football field) and 6 feet wide.

There were 2 groups: placebo and Pharma-GABA. Salivary immunoglobulin A (IgA) levels (also known as secretary IgA or sIgA) was measured in both groups and used as a marker of relaxation and stress, as well as immunity. Saliva was collected before crossing the bridge, half way across and at the end. The study found that the

placebo group showed marked decrease of their IgA levels, while GABA group showed significantly higher levels.

And concludes as follows:

GABA could work effectively as a natural relaxant and its effects could be seen within 1 hour of its administration to induce relaxation and diminish anxiety. Moreover, GABA administration could enhance immunity under stress conditions.

The paper is reporting about 2 studies and it’s not clear how much Pharma-GABA was used in this bridge study – it was either 100mg or 200mg. Results were observed within 60-90 minutes. Also, this study was conducted by the company who makes the Pharma-GABA product, and they do say that this bridge study includes unpublished data.  Notice that they use the term GABA in the paper – I prefer to differentiate since Pharma-GABA and GABA are actually different.

Other than this and the very small number of participants, I’m always encouraged by any research we have. Clinically, we see very similar results with GABA or Pharma-GABA when someone has a fear of something – heights, flying, spiders etc. – and it typically addresses the physical fear and anxiety symptoms.

Here are some of my thoughts as to why results were only observed after 60 minutes:

  • Pharma-GABA was used in the study and for some folks this is not as effective as using GABA. I typically start my clients on GABA.
  • Using GABA sublingually often has calming results in under 10 minutes, so a chewable Pharma-GABA may have been a better option and would be something I’d recommend
  • Low serotonin is commonly a factor with fears and phobias and I’d recommend a trial of tryptophan

The resources in this blog and my other articles are intended to be used in conjunction with my book: The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings (Amazon link). If you do not have my book I highly recommend getting it and reading it before jumping in and trialing/taking amino acid supplements: There is a complete chapter on the amino acids and one for pyroluria, plus information on real whole food, sugar and blood sugar, gluten, digestion and much more.

You can find the GABA and tryptophan products I recommend on this blog: The Antianxiety Food Solution Amino Acid and Pyroluria Supplements

How would you feel walking across a swaying suspension bridge like this?

Have you used Pharma-GABA, GABA and/or tryptophan to help you with the stress and anxiety caused by a phobia like this or another phobia?

Tyrosine for alleviating anxiety and panic attacks and creating a feeling of calm focus

By Trudy Scott 72 Comments

If you had anxiety, felt hugely stressed and were having panic attacks would you consider using tyrosine to help calm you? It’s not the first approach I use with a client as I typically want to calm things down first by addressing the low serotonin symptoms of anxiety (such as worry, overwhelm, insomnia and panic attacks) and the low GABA physical symptoms of anxiety (physical tension, stiff and tense muscles, overwhelm and panic attacks).

However, for some individuals addressing low catecholamines with tyrosine is the best approach to take, even if it feels counter-intuitive. Since everyone is different using the trial method is the best way to figure out what you need.

Here is another success story from someone using tyrosine, as shared in the comments on a recent blog post on tyrosine:

Tyrosine for anxiety has done wonders for me! I have tried GABA and Tryptophan. The GABA seemed to take the edge off a little when panic attacks occurred but wasn’t keeping anxiety from occurring.

I have been under tremendous pressure at work. The internal stress has been overwhelming! I haven’t been able to remember anything, even things I’ve done for years! I am in the process of learning new software at work. In the very first class my mind just went blank. The more I tried to focus the more stressed I became. All I could do was sit and stare at my screen while the rest of the class moved forward.

In short order I developed a migraine and panic. The internal pressure felt as if someone was wringing out my brain like one would do to a wash rag! I had to leave the class earlier. From this point on I was struggling to even do my job as I have done the last few years. Every time I tried to think I’d immediately become overwhelmed and shut down. I felt like crying most of the time from the sheer force of the internal pressure (this is embarrassing to admit as I’m someone with a competitive career). This stress just completely shut down my ability to learn and problem solve.

So, I decided to start some tyrosine. I was hesitant because I have heard it can cause panic attacks and I definitely don’t need more of those! I bought some powder and took 400mg on an empty stomach about 30 minutes before breakfast. WOW!!! Within an hour the stress just melted away!

I wasn’t stressed on my way to work either which normally I am. I was able to sit down and think thru my problems without feeling overwhelmed at all. Also, I was communicating with people much more easily. I noticed better eye-contact. I seemed less concerned of anyone’s opinions too.

I take another 400mg 30 minutes before lunch. I simply cannot believe how much better I am doing!

Just a few weeks prior I was telling my wife that I may need to start thinking about starting the process for disability because I simply could not function well enough to do my job.

I’d also add that the stress from the anxiety was so bad I felt like I had the flu for a few weeks. This also has dissipated since starting the tyrosine.

It’s still early in this experiment but I am hopeful for once. Nothing, and I mean NOTHING has worked so well so fast for me than tyrosine. It’s the closest thing to a miracle I’ve ever experienced. A night and day experience!

What wonderful results! I’m thrilled to hear about his “miracle” and that he’s doing so much better, that he has hope and that the stress from the anxiety has dissipated!

What approach to follow if you can relate to this situation

Of course, I thanked him for sharing his success story with tyrosine and added my response for other blog readers who may relate to this situation and may consider a trial of tyrosine as a first step when anxiety is an issue.

I still stand by my advice to start with GABA and tryptophan when you have anxiety whether it’s the low serotonin-type anxiety (worry in the head) or the low GABA-type anxiety (physical anxiety). I always have clients start by addressing these deficiencies first before adding tyrosine for the low catecholamine symptoms because tyrosine is too stimulating for many and can increase anxiety and insomnia (and may also cause a panic attack).

With the majority of the anxious clients that I’ve worked with, the order of doing trials is as follows: tryptophan or GABA first and then tyrosine.

Addressing his low catecholamine symptoms was what he needed

For this gentleman, clearly GABA and tryptophan support was not what he needed or was not enough to ease his anxiety. Addressing his low catecholamine symptoms was what he needed to do.

In case you’re wondering how he’s doing now – I reached out to him and he reports he’s still taking tyrosine and is still doing great!

He is the third person that I know of who has experienced these types of results with tyrosine so I expect there are others who could benefit too – which is why I decided to share his story.

Increased anxiety because of lack of focus and low motivation

Here is another similar story from a prior client of mine. She had terrible anxiety, and we trialed both GABA and tryptophan. While she did get some benefits with both it just wasn’t enough.

She was sleeping better but still felt so stressed and anxious when preparing for an important meeting at work which she was in charge of running. The anxiety also seemed to get worse during the meetings. She did also score high on the low catecholamines section on the amino acid questionnaire (poor focus, low motivation, fatigue, ADHD, depression) but were working on the low serotonin and low GABA types of anxiety before addressing poor focus and low motivation.

It turned out that her anxiety escalated around her work meetings because of her lack of focus and low motivation – she was pushing herself to get through them. Once she added tyrosine her anxiety was under control. In this instance tyrosine actually helped ease the anxiety because her ADHD symptoms diminished and her motivation and drive improved!

This is what biochemically individuality is all about and how we all have our own unique needs. And is why I love the trial-method for determining which amino acid is best for your own unique needs.

Here are some related blog posts that you may find helpful:

Do let us know if you have experienced less anxiety and a sense of calm focus when taking tyrosine?

GABA reduces the visceral pain of IBS & SIBO, eases anxiety and helps with insomnia

By Trudy Scott 6 Comments

I have chronic SIBO (small intestinal bacterial overgrowth) and shared some insights – during an interview on the IBS & SIBO SOS Summit – on what helps me when I’m trying a new protocol or new food and get that awful and painful belly bloat.

It’s so bad that I’m in pain all night, tossing and turning and can’t sleep…. and Iberogast, enzymes and peppermint and lavender essential oil on my bloated belly help so much:

Because of the cellulose in one of the Candibactin products, I was getting the bloating. And the Iberogast taken at night just before I went to bed (together with a few other things) definitely helped with some of the bloating.

For me, the problem with the bloating is the pain (obviously), but worse than that is the lack of sleep. If I’m bloated, it just feels like I’m tossing and turning the whole night. And if I don’t get eight hours of sleep, I’m a mess. So, the biggest issue for me is the impact on my sleep.

But if I’ve got this huge, bloated belly which was happening a lot, I take enzymes that help with carb digestion. I will also rub peppermint essential oil on my belly. So I’ve got a little bowl of coconut oil with a dab of lavender (it’s calming and it helps you sleep as well) and a little bit of peppermint oil.

There’s a number of studies showing that essential oil or peppermint ingested in a capsule can help with IBS. And I’ve found that, topically, it can help too. So that works for me to help with some of the bloating.

I also share about my 2 favorite amino acids – you guessed it – GABA and tryptophan. They just have so many applications! In this instance of painful belly bloating they help with pain and sleep and improve motility:

The other thing that helps is GABA which is one of the amino acids. There is research discussing the role of GABA in stress-induced visceral hypersensitivity. GABA helps with reducing the visceral pain that is seen with IBS/SIBO because we have GABA receptors in various parts of the body, including the digestive system. GABA is amazing for physical tension/anxiety and it can ease that. I’m thinking that this easing of physical tension may be one of the mechanisms as to how it works for some of the pain issues.

I do want to mention something about GABA – it works most effectively when taken sublingually. I just chew a capsule and get the results. And it works within five minutes.

And then, the other one that I use at night is tryptophan. This really helps with the sleep as well by boosting serotonin levels. It actually helps with motility too – there’s research showing this.

If your SIBO causes increased anxiety, these two amino acids would help ease those symptoms too – GABA for the physical anxiety and tryptophan for the worry in the head anxiety:

And then, it helps with anxiety as well if that’s an issue – for many people with IBS and SIBO, anxiety is an issue.

Summit host, Shivan Sarna, shares how LDN (low dose naltrexone) has helped her tremendously (she also has chronic SIBO) and we discuss how too much can increase anxiety and impact your sleep. Since doing this interview I’ve had feedback from two people who successfully used GABA Calm to reduce their anxiety from too high a dose of LDN.

We also touch on some of the possible mechanisms of LDN, I share some of the benefits of berberine, and we discuss benzodiazepines which are so often prescribed for IBS/SIBO (for the anxiety, the insomnia and the pain) and why nutritional approaches are a safer option.

Have topical peppermint/lavender essential oils helped with belly bloat?

Has GABA or tryptophan helped you with the pain, poor motility or anxiety associated with SIBO?

Feel free to post your feedback and questions in the comments below.

The healing properties of camel’s milk for autism (and anxiety)

By Trudy Scott 8 Comments

Kaalya Daniel, PhD covers the very interesting topic of camel milk in her interview on The Nourishing Hope for Autism Summit

How You Can Use the Healing Properties of Camel’s Milk for Autism

Camel’s milk is like no other milk. You’ll learn the unique and powerful immune system properties and nutrient benefits of this milk, from an animal known to endure extreme conditions. And how it helps with autism, even when you can’t tolerate other milk.

I don’t have access to the interview transcript yet but since this is a new topic I haven’t yet blogged about I’ve decided to highlight this interview as one I’m really interested in exploring for mom’s in my community with children on the spectrum, with ADHD or other developmental disorders.

In case you’re new to camel’s milk, a paper published in 2015 – Nutritional and Therapeutic Characteristics of Camel Milk in Children: A Systematic Review, shares the following:

Camel milk is the closest to a human mother’s milk. Camel milk is different from other milks, however, having low sugar and cholesterol, high minerals (sodium, potassium, iron, copper, zinc and magnesium, and vitamin C). The milk is considered have medicinal characteristics as well.

The study concludes that there is evidence denoting the importance, usability and benefits of camel’s milk:

Camel milk as a supplemental treatment seems less invasive and costly than specialist care, medications, alternative treatments, and behavioral interventions. Based on our findings, camel milk is safer for children, effective in the treatment of autism, improves general well-being, promotes body natural defenses, is a good nutritional source, and can helps the daily nutritional needs of humans.

Given the many overlaps we see with autism/ASD and anxiety/depression, it’s clear that camel milk has wide applications given the benefits we see has for immunity, the gut and inflammation, as well as providing nourishment when dairy cannot be tolerated. As you can see in the above study below camel milk consumption has been shown to improve general well-being.

I’m not sure if anxiety and GABA is covered in the interview but I did find some interesting research reporting that both camel and goat milk have significantly more bioavailable GABA than cow and human milk – which may be another beneficial mechanism.

Here are just a few of the other speakers and topics I’m really looking forward to hearing:

  • James Adams, PhD: The Scientific Evidence Linking Nutrition and Autism Improvement
  • Dietrich Klinghardt: Understanding Lyme, Infections, Mold, and Heavy Metals and the Effects on Autism
  • Chef Pete Evans: Food is Medicine, Inspiration from a chef
  • Dominic D’Agostino, PhD: Is the Ketogenic Diet Right for an Autistic Child?
  • Susan Owens, MS: The Inflammasome, Oxalates, Autoimmunity and Autism
  • And of course, Julie Matthews, CNC: When GFCF Diets Don’t Work – BioIndividual Nutrition for Autism (I’m actually going to interview Julie on this topic)

In my interview we go into anxiety, OCD and aggression in great detail, discussing the amino acids GABA and tryptophan, plus gluten issues and when and how to use inositol.

This summit provides you with information and tools that address the root causes of autism, ADHD and many other conditions including anxiety.

The Summit runs July 30 to August 3 and is hosted by my dear friend and colleague Julie Matthews, whose work you’re probably very familiar with. In case Julie’s work is new to you, in my eyes, she is THE autism nutrition expert. I’ve had the pleasure of interviewing her a number of times on the Anxiety Summit, I endorse her Bioindividual Nutrition training (special diets) for practitioners, I highly respect the work she does and I adore her!

Register here for The Nourishing Hope for Autism Summit to learn more! It airs online from July 30 to August 3, 2018. Hope to see you online!

I’d love to hear your camel’s milk experiences. If you have questions please post them in the comments below.