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Fipronil insecticide: GABA/glutamate and anxiety, aggressive behavior, memory and Alzheimer’s disease in humans?

October 5, 2018 By Trudy Scott 15 Comments

The insecticide called fipronil has me concerned because there is increasing evidence that it can be toxic to humans and, much to my surprise, I’ve just discovered that the main mechanism of action is by targeting the gamma-aminobutyric acid (GABA) receptor and recent research points to increased anxiety, aggressive behavior, memory problems and even Alzheimer’s disease in animal studies.

Based on a rather surprising conversation I had with someone a few weeks ago (let’s call her Sue), I felt compelled to get more information on fipronil. Before that I was not aware about the specific effects I mention above.

We were in Sue’s front yard and the dog kept sniffing these small white plastic squares in the flower beds. Sue kept pulling the dog away and I asked “why? what are those?” It turns out they were ant-bait devices. Yes, I’m this clueless simply because I’ve never purchased anything like this. I expressed my concerns about toxicity and possible endocrine/hormone effects but didn’t have enough concrete facts, so I went digging through the research. Needless to say I am very concerned with what I found.

What was equally concerning is that Sue had not even considered that it could be harmful. Looking into possible harms was not even on her radar. When pressed, Sue said “it’s only a small amount in each container so I’m sure it’ll be fine” and “the poison is inside the container so none of it will come out – so it’ll be fine.”

This is what went through my mind (which is pretty typical for me – I’m always in questioning mode): What is it and how toxic is it? Does it have impacts on humans and by what mechanism? Could it cause anxiety or increase existing anxiety symptoms? Are there additional concerns about it being in a flower-bed near the front door where you could possibly walk some into the house or breathe it in as you come and go?

Organophosphates and psychological effects

Organophosphates are a commonly used pesticide used on fruits and vegetables and research going as far back as 1994 reports that acute exposure can cause psychological effects because they

act directly on the nervous system by inhibiting the neurotransmitter acetylcholine … [contributing to] … acute psychological and behavioral effects, such as anxiety, depression, and cognitive impairments.

The researchers also suggest that long-term psychological effects of low-level exposure have not been determined satisfactorily.

We hear less about insecticides such as fipronil

We hear less about insecticides such as fipronil and how they work.

According to the National Pesticide Information Center Fipronil is a broad use insecticide that

belongs to the phenylpyrazole chemical family. Fipronil is used to control ants, beetles, cockroaches, fleas, ticks, termites, mole crickets, thrips, rootworms, weevils, and other insects.

Fipronil is used in a wide variety of pesticide products, including granular products for grass, gel baits, spot-on pet care products, liquid termite control products, and products for agriculture.

It can be found in ant-bait and anti-cockroach products as well as Frontline Plus (tick and flea protection) for cats and dogs. You can find a partial list of products here and a fact sheet here.

GABA & glutamate: anxiety, aggressive behavior and neurotoxic effects

Fipronil works to kill insects via the inhibition of glutamate- and GABA-activated chloride channels resulting in uncontrolled neural excitation. It also blocks GABAA receptor function and is typically considered toxic to insects but not humans.

As soon as I read the GABA-glutamate mechanism I started searching for anxiety and neurotoxic connections.

There are no human studies on increased anxiety due to fipronil exposure but research on zebrafish larvae exposed to fipronil at typical environmental levels, finds anxiety-like behavior.   In the paper, A metabolomic study of fipronil for the anxiety-like behavior in zebrafish larvae at environmentally relevant levels, the authors report decreased levels of glycine and serine with higher levels of glutamate saying fipronil may be a potential neurotransmitter disruptor. Here are some of the possible mechanisms they discuss related to this:

  • The decreased metabolite glycine caused by fipronil may contribute to the excitatory swimming performance. Whether the glycinergic reciprocal receptor (GlyR)…inhibitory mechanism is also involved in low level of fipronil [exposure] requires further investigation.
  • Additionally, as one of the most abundant amino acids in microenvironment stress, proline is biosynthetically derived from the amino acid L-glutamine. Low levels of L-proline detected in fipronil-treated group may indicate the accumulation of glutamine. As an excitatory neurotransmitter, high level of glutamine would associate with the excitatory behavior of the fish.

In another study, Prenatal exposure to fipronil disturbs maternal aggressive behavior in rats, the authors suggest fipronil impacts the central nervous system areas that control aggression and increases in maternal aggressive behavior are via impacts on GABA(A) receptors.

This 2016 paper lists a variety of toxic effects to both animals and humans: Fipronil insecticide toxicology: oxidative stress and metabolism:

because of accidental exposure, incorrect use of fipronil or widespread fipronil use leading to the contamination of water and soil, there is increasing evidence that fipronil could cause a variety of toxic effects on animals and humans, such as neurotoxic, hepatotoxic, nephrotoxic, reproductive, and cytotoxic effects

They explore oxidative stress as a possible mechanism as to how fipronil causes these toxic effects.

Does concrete make fipronil more toxic?

One of the questions I asked myself was this: Are there additional concerns about it being in a flower-bed near the front door where you could possibly walk some into the house?

It turns out that this may be a valid concern. In this 2016 paper, Conversion of pesticides to biologically active products on urban hard surfaces, the researchers report that urban landscapes that include concrete can actually convert pesticides to other biologically active and more toxic intermediates, likely caused by the alkalinity and metal oxides in concrete. They report that fipronil:

was quickly transformed to desulfinyl and sulfone derivatives, with the desulfinyl level exceeding that of parent in the runoff water only 1week after treatment. Fipronil derivatives have aquatic toxicity similar or even greater than the parent fipronil.

Impacts on memory and a possible factor in Alzheimer’s disease

This 2016 animal study, Memory impairment due to fipronil pesticide exposure occurs at the GABAA receptor level, in rats concludes that fipronil can

have toxic interactions with the CNS [central nervous system] of mammals and lead to memory impairment by modulating the GABAergic system.

We also have to ask how big a role this insecticide could be playing in Alzheimer’s disease? In a paper published earlier in 2018, Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides, they use the term “Alzheimerogens” when writing about insecticides such as fipronil and the metabolite fipronil sulfone:

Focusing on fipronil, we showed that some of its metabolites, in particular the persistent fipronil sulfone, also favor the production of Aβ42/Aβ43 in both cell-based and cell-free systems.

Fipronil administered orally to mice and rats is known to be metabolized rapidly, mostly to fipronil sulfone, which stably accumulates in adipose tissue and brain.

In conclusion several widely used pyrazole insecticides [such as fipronil] enhance the production of toxic, aggregation prone Aβ42/Aβ43 peptides, suggesting the possible existence of environmental “Alzheimerogens” which may contribute to the initiation and propagation of the amyloidogenic process in sporadic AD.

The paper shares that amyloid-β peptides (Aβs), especially increased production of Aβ42/Aβ43 over Aβ40, represent a characteristic feature of Alzheimer’s disease.

Why wait for long-term human studies?

Hopefully you’re like me and don’t buy ant-bait or roach-bait products.

My bigger concern is the wide-spread use of spot-on pet-care products which contain fipronil, exposing our beloved pets to this toxin and all the humans they come into contact with. Pet-groomers are especially cautioned. And I’d also add a caution for children playing with pets where these flea and tick products are used since “the developing brain is particularly vulnerable to the action of insecticides.”

We don’t know for sure how harmful this insecticide is for humans and it’s not clear what the mechanisms are – GABA-glutamate and/or glycine and/or oxidative stress – but why wait for long-term human studies, especially given that chronic and long-term effects are difficult to investigate and based on what we already know about their effects on Parkinson’s disease, amyotrophic lateral sclerosis, and depression.

I have found enough information to be very concerned and to feel justified in continuing to avoid fipronil. I encourage you to avoid fipronil as well.

This is especially the case if you already suffer from long-term anxiety, insomnia or another chronic health condition as it may be one more possible contributory factor.

Given that fipronil blocks GABAA receptor function, I have to wonder if chronic long-term exposure could play a role in difficulties with benzodiazepine tapering.

If this is old news to you feel free to share with family and friends who may not be as informed as you.

If this is news to you, I hoping this gets you thinking and questioning. I’d love to hear your thoughts, concerns and questions.

 

[The above statements have not been evaluated by the Food and Drug Administration. Products listed in this blog post are not intended to diagnose, treat, cure or prevent any disease.]

 

The amino acids and pyroluria supplements I use with my clients

Additional Anxiety Resources
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Filed Under: GABA Tagged With: aggressive behavior, Alzheimer’s disease, anxiety, anxious, benzodiazepine, fipronil, GABA, insecticide, memory, pets

About Trudy Scott

Food Mood Expert Trudy Scott is a certified nutritionist on a mission to educate and empower anxious individuals worldwide about natural solutions for anxiety, stress and emotional eating.

Trudy is the author of The Antianxiety Food Solution: How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood and End Cravings and host of The Anxiety Summit now in its 6th season and called a “bouquet of hope.”

Trudy is passionate about sharing the powerful food mood connection because she experienced the results first-hand, finding complete resolution of her anxiety and panic attacks.

Reader Interactions

Comments

  1. Sarah LoBisco, ND, IFMCP says

    October 5, 2018 at 10:05 pm

    Thank you so much, Trudy, for providing the research and references! This is imperative to get out!
    Much appreciation!
    Sarah LoBisco, ND, IFMCP

    Reply
    • Trudy Scott says

      October 5, 2018 at 11:10 pm

      Sarah
      You’re most welcome – and I agree we need to be looking at and sharing this growing area of research.

      I’d love to hear your thoughts on the fact that fipronil blocks the GABAA receptor and how this may adversely impact those trying to taper from benzodiazepines?

      Reply
  2. Leslie says

    October 20, 2018 at 5:33 pm

    Thank you Trudy! This is valuable information.

    Reply
  3. Brianna says

    February 12, 2019 at 8:28 pm

    Thank you for this article. I was an exterminator for 5 years and many of the products we used had Fipronil in them. I got out of the field because my body could not handle the exposure to the pesticides any longer. Then, my worst complaint was the rash all over my hands, arms and back. Now 5 years later I just can’t remember anything. It started with forgetting small things and now I can’t remember what I did a minute ago. It’s frustrating beyond belief.

    Reply
    • Trudy Scott says

      February 12, 2019 at 8:35 pm

      Brianna
      Sorry to hear. I have clients who have been exposed to toxins work on detox strategies and nutrients – sauna, coffee enemas, activated charcoal, glutathione etc. And working with someone to identify nutritional deficiencies is key as memory issues can be addressed.

      I’m curious if you had/have any anxiety issues given that it depletes GABA levels?

      Reply
  4. Brianna says

    February 18, 2019 at 6:50 am

    I do have anxiety issues, although I always have. I was an exterminator between 18-23 years of age. During that time I was on anxiety medication but now I try to manage without it. My anxiety was so bad at times I would have to pull over on the way to work to throw up. The place I worked at was stressful as the owner was going through personal issues.

    Reply
  5. Paul says

    July 1, 2019 at 10:00 am

    My mom went to dominican republic and got sick down there like all the people on the news lately. 3 years agonshe had rapid weight lossnand stomach pain. She now is diagnosed with alzheiners and anxiety recently. It sounds lije insecticide poising to me. Is there anyway to help her.

    Reply
    • Trudy Scott says

      July 5, 2019 at 12:01 am

      Paul
      Best to have her work with a functional medicine doctor well versed in Dr. Dale Bredesen’s work on Alzheimer’s and find the root cause/s. While figuring things out the amino acids such as GABA and tryptophan could be trialed for her anxiety

      Reply
  6. Deb Reweti says

    May 1, 2020 at 4:39 pm

    Very interesting article. I can see how easily each of my kids could have had exposure to ‘front line’. We used it all the time so our pets weren’t bringing fleas and parasites into our home… I remember the kids patting our cat and having Frontline all over them. . So I wonder now, has anyone come up with a way to treat fleas ticks and parasites, without such a harmful ingredient?..
    do you know of an alternative product, that won’t poison us?..

    Reply
    • Trudy Scott says

      May 7, 2020 at 6:35 am

      Deb
      There are a number of natural options available and some home-made options made with essential oils.

      Reply
  7. Clare says

    March 13, 2022 at 11:04 pm

    Hi Trudy, thanks so much for this. I have a dog who suffers from reactivity caused by extreme anxiety- she clearly has an imbalance that means she is in fight or flight often. I now wonder if there should be MORE animal studies on this basis!
    As she is a dog not a human I struggle to find the best supplements for her for neurotransmitter support, the ones I have found just don’t contain high enough doses.

    Reply
    • Trudy Scott says

      March 15, 2022 at 6:09 pm

      Clare
      I would love to see studies on the harms of this to animals! What products have you found for her and do they help at all?

      Reply
      • Clare says

        March 22, 2022 at 3:58 pm

        Hi Trudy,
        No they don’t. We have tried a lovely powder called Petz Park that our behaviourist recommended, Blackmores PAWS calm chews, and CBD oil.

        The only thing that makes her less reactive is unfortunately Fluexotine.

        But this isn’t a good long term solution and I just know that supporting the precursors and co-factors for her neurotransmitters makes more sense. But not being a vet I can’t just go ahead and decide what she needs. Very frustrating.

        Interestingly, almost every time we walk her we pass yet another dog who the owners volunteer to be anxious. At least one every day!

      • Trudy Scott says

        March 25, 2022 at 6:49 pm

        Clare
        We use the amino acids in pets in a similar way we do in humans – start low and increase until we get the desired effects. I like the look of Blackmores PAWS however using tryptophan in a product that also has kangaroo meat is not helpful as tryptophan needs to be used away from protein.

        When a SSRI works it’s a clue serotonin support is needed and we pursue this with nutrients.

        Very sad that so many dogs are anxious

  8. Clare says

    March 27, 2022 at 4:24 pm

    Hi Trudy. I agree with the protein-amino acid contest. But I don’t know how to safely administer tryptophan to her, and I found that trying to build precursors via foods was difficult, unlikely to hit the mark and a bit much for her tummy.
    Sorry, I realise this is a human related thread! I just cannot find any assistance and I know it’s worth a try. Anxiety is really on the rise with pets as it is children and it certainly isn’t purely pandemic related.

    Reply

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