low serotonin

Flight anxiety with heightened breath, physical tension and also fearing the worst (the role of low GABA and low serotonin)

September 19, 2025 By Trudy Scott Leave a Comment

Do you have suggestions for supplements for flight anxiety, something to make flying bearable without heightened breath, etc, or is that out of the supplement realm?

I also have physical tension and fear the worst. Any kind of turbulence or warnings of turbulence makes me extremely nervous.

K asked this question on one of my blogs and I responded that this is very much in the supplement realm! And what we use depends on the type of anxiety someone is experiencing.

I would first consider serotonin support before and during flying – tryptophan or 5-HTP – because she fears the worst and feels extremely nervous. With low serotonin there may also be worry and fear leading up to the trip, as well as feelings of panic and imagining the worst during the flight.

GABA support – using the amino acid GABA or theanine – should also be considered for the more physical symptoms of heightened breath and physical tension. With low GABA there can be other physical symptoms such as excessive sweating (like the palms), a racing or pounding heart and a dry mouth. These amino acids could also be used leading up to the flight and during the trip if needed.

Read on for more on my insights on using these amino acids in a situation like this, additional information about fear of flying and a success story with GABA.

Serotonin and/or GABA support for fear of flying

In an ideal situation I would want to address both low serotonin and low GABA before flying and have her use extra during the flight, as needed. It’s very likely that many of the low serotonin and low GABA symptoms are present in some way in her day to day life too.

This means she can be methodical about doing a trial of the respective amino acids and figure out the optimal dose of each in familiar surroundings – using powder, capsule opened, sublingual, chewable or liposomal.

As always we trial one at a time so we know which one is working best. Keep in mind some folks do better with tryptophan and some do better with 5-HTP so both may need to be trialed. The same can be said for GABA and theanine.

Once the product and dose of each has been figured out, she’ll need to find a suitable option for use while traveling i.e. a sublingual or chewable tablet

It’s always a comprehensive approach

It’s a comprehensive approach – amino acids AND diet so I recommend eating real whole food, quality animal protein, eating for blood sugar stability, going gluten-free, sugar-free and caffeine-free, eating healthy fats, organic vegetables and fruit and fermented foods. My book “The Antianxiety Food Solution” is a great place to start when you are new to the amino acids and other anxiety nutrition solutions like gluten/sugar/caffeine removal, blood sugar control, gut health, pyroluria etc.

During travel it’s important to be prepared with healthy travel foods and drinks. I share some ideas here.

The definition of a specific phobia such as the fear of flying

The fear of flying is called aviophobia and it’s one of many common phobias about something specific. According to this ebook

Specific phobia is an anxiety disorder characterized by excessive and irrational fear of a particular object, situation, or activity. The anxiety response goes beyond normal apprehension and leads to avoidance behavior. The intensity of the fear is often disproportionate to the actual danger posed by the phobic stimulus.

Common examples of specific phobias include fear of heights (acrophobia), fear of spiders (arachnophobia), fear of flying (aviophobia), and fear of needles (trypanophobia). People with specific phobias may experience intense anxiety or panic attacks when exposed to the feared object or situation.

This Australian article reports that “One in six people have a significant fear that prevents them from flying, and about one in five regular flyers use alcohol or prescription drugs to “help” them through a flight, according to Victoria’s Department of Health.”

Using the amino acids to address low serotonin and/or low GABA addresses the root cause and does away with the need for alcohol and antianxiety meds (and the associated side-effects).

Cognitive behavior therapy (CBT) and exposure therapy is often recommended for aviophobia but doesn’t always help, and doesn’t address the biochemical imbalances.

A success story with GABA before and during a flight – cool as a cucumber

Melissa started using Source Naturals GABA Calm in anticipation of holiday travel and holiday gatherings and shared this:

I’m glad I saw the post about GABA on your FB page a couple weeks ago. I bought Source Naturals GABA Calm and have been taking 1-3 per day for two weeks.

I’m glad I bought it before travelling home for Christmas – I was cool as a cucumber at the airport and was much calmer when visiting family and friends compared to last year! The true test of its efficacy will be in two weeks when the semester starts. For now, I notice a general calmness and am sleeping well.

Notice that she started using it in the 2 weeks leading up to her trip and not on the flight itself.

Additional resources when you are new to using tryptophan or GABA and other amino acids as supplements

We use the symptoms questionnaire to figure out if low serotonin or low GABA or other neurotransmitter imbalances may be an issue for you.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings. I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control (this is covered in an entire chapter too), sugar cravings, anxiety and mood issues. The importance of quality animal protein and healthy fats is also covered.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms too). This is a paid online/virtual group program where you get my guidance and community support.

If you need serotonin support, the Serotonin QuickStart Program is a good place to get help. This is also a paid online/virtual group program where you get my guidance on using tryptophan and 5-HTP safely, and community support during 5 LIVE Q&A calls. You can sign up to be notified when the next live launch of this program is happening.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Have you had success using serotonin and/or GABA support for your fear of flying (or other phobia/s)? If yes, which amino acids have helped you?

Did you have any success with CBT or exposure therapy or other approaches?

Feel free to share and ask your questions below.

Tryptophan and GABA for relaxation, jaw pain, sleep, anger and mood symptoms

June 13, 2025 By Trudy Scott 10 Comments

I typically start clients on tryptophan if they have signs of low serotonin: stressed, overwhelmed worry, fears, obsessing, feeling anxious, ruminations, low mood, anger issues/rage, sleep problems, pain issues, PMS, low self-esteem, imposter syndrome, and afternoon/evening carb cravings etc. If we don’t get expected results we switch to 5-HTP as some people do better on one vs the other.

With signs of low GABA – a more physical kind of anxiety, with some overwhelm, intrusive thoughts, tension, sleep issues (often lying awake tense), stress-eating and/or drinking and pain – I typically recommend a GABA only product (as a powder or capsule opened) or GABA Calm (a sublingual). In some cases we may consider theanine and pharmaGABA.

The best way to assess low GABA and low serotonin is the symptoms questionnaire and a trial of the respective amino acids – one at a time. But the key is to find the ideal amount for the unique needs of each person. We do that by methodically and systematically increasing the amino acid slowly and tracking improvements for each increase.

In this blog you can read some success stories from women who used tryptophan and GABA for relaxation, jaw pain, sleep, anger and mood symptoms, and my commentary with some additional insights.

Tryptophan and GABA (as powders) – for her stress and pain

Amy uses both tryptophan and GABA for relaxation and jaw pain:

I use both tryptophan and GABA, I just take them separately. When my jaw was really bad the tryptophan really helped. I also do vagus nerve stimulating exercises that make me yawn and it stretches and releases the jaw.

As for the GABA …when I’m very stressed, I need extra to feel the effects. I use a pinch between the fingers of the Now powder and let it dissolve on my tongue. I feel my body relax in about 30 seconds. If nothing then I take a second pinch. Most days 1 pinch is enough.

I also let tryptophan dissolve in my mouth and most days I feel the same physical relaxation after a few moments. It’s not always obvious with the tryptophan though. I use 1/4 tsp of powder but you can use capsules. I mix the powder with pudding powder because it’s very bitter.

Both tryptophan and GABA can help with pain, and also feeling anxious and stressed.

The benefits are via different mechanisms – tryptophan boosts low serotonin and it’s typically more of a mental type of relaxation. This blog illustrates the use of tryptophan for TMJ (temporomandibular joint) – Tryptophan ends TMJ pain, headaches and worry, and improves mood and sleep: a success story.

The amino acid GABA boots low GABA levels and it provides more of a physical type of relaxation and also helps with pain relief.

I like that Amy is using both amino acids as powder and I’m happy for her. GABA powder tastes pleasant and is much more effective used this way (or capsule opened or sublingual).

Tryptophan can be swallowed but many find it more effective as a powder or capsule opened. As Amy says, it’s very bitter as a powder.

Tryptophan or 5-HTP and different forms of GABA – for sleep, anger and mood symptoms

Kerry tried 5-HTP and pharmaGABA but did better with tryptophan and GABA Calm:

My naturopath had me on 5-HTP but I never felt a benefit, and pharmaGaba was a histamine trigger. After reading your book I tried tryptophan and spent many months on 2 x 500mg at bedtime. This helped with sleep and definitely stopped the surges of anger that happened often.

I read a lady say her staple was 2 x Gaba Calm at bedtime and on rising, so I tried this and it helped.

I now take both tryptophan and Gaba Calm only if I feel niggly mood symptoms.

My previous diet was standard vegetarian, then vegan for several years. I now have lots of protein in the form of beef liver capsules, eggs and protein powder. I don’t like meat.

Kerry shared all this in a recent blog comment, describing how tryptophan and GABA Calm were big game-changers for her, in addition to “a long slow mold detox …addressing nutritional deficiencies and implementing dietary changes.”

Mycotoxins caused by mold, nutritional deficiencies and a poor quality diet can impact neurotransmitter production. The good news is that when you find the right combination of amino acids – in this case tryptophan and GABA Calm – you can get relief right away while the other factors are being addressed. It reduces the overwhelm, stress and fears too.

Kerry’s approach of consistent use of both amino acids is the best way to go and I’m so happy for her. And once levels are sufficient they can be used as needed, provided other underlying causes (like toxins, diet etc) are being addressed.

I will add that some individuals do better on 5-HTP and some do better on tryptophan so it’s often a matter of doing a trial of both. I typically recommend tryptophan to start because 5-HTP can be an issue if cortisol is high.

I also always recommend starting with some forms of GABA because of the potential histamine issues with pharmaGABA. That said, some individuals do tolerate pharamGABA so it’s worth doing a trial of both. And we may also consider theanine when we want to support low GABA, low serotonin and low dopamine.

Theanine and tryptophan and diet/lifestyle changes – and feeling her best!

Luna worked with a health practitioner to taper off Prozac (very slowly) and used amino acids during the taper and afterwards:

As someone who took Prozac for years and eventually came off, please pay special attention to Trudy’s advice to come off it SLOWLY. I’d say do it so slowly it may seem ridiculous.

I tried three times to get off Prozac and it was only with the help of an ND/PharmD did I finally get the info needed to come off it without *awful* side effects. To do it well, the process takes MONTHS – not weeks as many doctors recommend.

These days, I take L-Theanine and L-Tryptophan. And I’m preparing to add some GABA soon. Combined with daily 45 minute walks outside, and a low-sugar/low-gluten diet, I’m doing the best I have in my adult life.

A comprehensive approach that includes amino acids, dietary changes, and getting out in nature can make a world of difference. I love it when I hear feedback like this.

Additional resources when you are new to using tryptophan and GABA and other amino acids as supplements

As always, I use the symptoms questionnaire to figure out if low serotonin or low GABA or other neurotransmitter imbalances may be an issue.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support.

Wrapping up and your feedback

Now I’d love to hear from you – how has tryptophan and GABA helped you or a loved one?

If you’d like to get on the notification list for the next Serotonin Quickstart Program (a paid online/virtual group program where you get my guidance and community support during 5 LIVE Q&A calls), please do so here.

If you’re a practitioner do you use tryptophan and GABA with your clients/patients?

Feel free to share and ask your questions below.

GABA helps ease symptoms of anger, rage, and dark moods (symptoms we typically associate with low serotonin)

June 30, 2023 By Trudy Scott 23 Comments

As a result of this wonderful feedback from a mom in the online GABA QuickStart program, I’ve been looking into GABA-anger connections. I’ve been trying to understand how GABA could offer similar benefits to tryptophan/5-HTP for anger, rage and dark moods, which we typically associate with low serotonin. She shares this:

My son who is 19 and on the autism spectrum was having issues with outbursts of anger and stuttering. These issues seemed to worsen during his senior year of high school. Since starting GABA and tailoring his dosage from Trudy’s instruction and feedback, we have seen a 90% reduction in stuttering and 80% reduction in anger and outbursts. We have done many supplemental protocols over the years and this is one of the few we have seen have an impact.

I am so happy for this young man and his family, and was also very intrigued. I’ve seen GABA help with stuttering. I have not noticed that GABA helps very much with anger/rage in clients but possibly because they are making other changes at the same time. Since they were in the program and he also had anxiety, we decided to continue with GABA.

I worked with them in the program over a few months and know he only changed one thing – GABA, starting low and increasing to find his ideal dose (with my guidance).

So I started to dig into the research, search through prior blog posts and ask on Facebook and the feedback is robust – folks are seeing GABA help with symptoms of anger and rage.

I share a few case studies below: how PharmaGABA helps a 9 year old boy with rages (part of his OCD/PANS), how GABA helps a young boy with Lyme-induced anger and how GABA helps a 9 year old girl with anger and dark moods (part of her PCOS).

I also share my insights with each case. And some possible mechanisms because we always want to understand why.

PharmaGABA helps 9 year old with rages that are part of his OCD/PANS

Kathy shares how pharmaGABA helped her son (on a pharmaGABA blog):

My 9 year old son had a lot of benefits from PharmaGABA. He used to have rages as part of his OCD/PANS. PharmaGaba 3 times a day was a miracle to get him through that period.

PANS is a neuropsychiatric disorder that falls under the same umbrella as PANDAS but is triggered by an infection other than strep.

If you’re new to PANS/PANDAS, I share the definition of PANDAS, from the PANDAS Network, in this blog: “PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) occurs when strep triggers a misdirected immune response that results in inflammation on a child’s brain. In turn, the child quickly begins to exhibit life changing symptoms such as OCD/obsessive compulsive order, anxiety, tics, personality changes, decline in math and handwriting abilities, sensory sensitivities, restrictive eating, and more.”

Both PANS and PANDAS trigger OCD/obsessive compulsive disorder. OCD is typically supported with tryptophan and/or inositol i.e. these obsessive thinking and behaviors are typically related to low serotonin even when there is an infection involved. The infection needs to be addressed but the tryptophan and/or inositol help to ease the obsessive symptoms.

Rage is a common symptom when serotonin is low. Tryptophan addresses low serotonin and can have a huge impact as I share in this blog – Rage, anxiety, cravings & insomnia in 11-year old girl with RAD/reactive attachment disorder: chewable tryptophan turns things around.

However, in this instance, pharmaGABA worked for the rages Kathy’s son experienced.

PharmaGABA is one form of GABA that has been shown to help with relaxation and anxiety.

GABA helps a young boy with Lyme-induced anger

Another mom shared this on a Lyme disease post on Facebook:

One kid has developed fits of anger that come out of nowhere but the GABA seems to be able to help him to play longer periods.

Lyme disease can also have a neuropsychiatric aspect, as shared by Dr. Suruchi Chandra MD. I’ve had the pleasure of interviewing Dr. Chandra on one of the Anxiety Summits and hear her present at integrative mental health conferences.

In one conference presentation she shared this: “Lyme disease is one of the fastest growing infectious diseases in the United States. It can remain dormant for years and then later mimic a number of psychiatric illnesses, including anxiety disorders, mood disturbances, psychosis, and autism-like behaviors. It can be further complicated by the presence of co-infections.”

Anger and rage are also common symptoms. In one study, “Lyme rage” is described as an anger episode that “had a very abrupt onset and was extremely intense and often with minimal cognitive control.”

Yet again, we often see GABA help ease some of the anxiety symptoms, as I share here – GABA helps with Lyme anxiety (while addressing the underlying disease).

However in this instance, GABA helped with her son’s anger symptoms induced by the Lyme bacteria.

GABA helps a 9 year old girl with anger and dark moods (part of her PCOS)

Debbie was diagnosed with PCOS (polycystic ovarian syndrome) and GABA helped ease her lifelong anxiety, wean off anxiety medication, ovulate each month and stop her PCOS medications. She was thrilled that GABA helps her daughter too. She shared how her oldest daughter who is 9 has been showing early signs of developing PCOS and other issues similar to hers:

When her mood started changing and she was getting angry out of nowhere and very dark and moody, I started her on a small dose of GABA. Immediately both of us saw the difference in her mood. She now asks for her “happy pills” daily because she doesn’t want to feel those dark feelings anymore. I wish this information was around when I was young. It could’ve helped so much of what I had to struggle with for years.

I typically think of tryptophan or 5-HTP as “happy pills”, and anger and a dark mood as symptoms of low serotonin.

However, yet again, GABA resolves these symptoms in Debbie’s daughter.

These are just a few of the many recent success stories I’ve heard about GABA and anger/rage.

Does low GABA anger/rage look different from low serotonin anger-rage?

This is all new to me so I honestly don’t know. We do know that low GABA leads to more of a physical kind of anxiety (i.e. felt in the body) and it’s different from low serotonin worry-type anxiety (i.e. it’s felt in the head).

Therefore, it’s possible that low GABA anger and rage has more of a physical aspect too.

I have yet to explore this aspect but feel it may be helpful to figure out if there is a difference in order to effectively use the neurotransmitter symptoms questionnaire. This questionnaire is used to decide whether to trial GABA or tryptophan/5-HTP and the low GABA section will be updated with anger/rage once I’ve gone a bit deeper with all this.

The kind of anger symptoms may well look the same and then we’ll use the clustering of either low GABA or low serotonin symptoms to base our decision for doing an amino acid trial.

Research: GABA may be critical in the neurochemical control of aggressive behavior and rage

There is no research that I am aware of where the amino acid GABA has been used to ease rage, anger or dark moods.

However, this letter, Tiagabine for Rage, Aggression, and Anxiety published in the Journal of Neuropsychiatry and Clinical Neuroscicnes in 2015 offers some round-about support to this GABA-rage observation. They are discussing patients with treatment-resistant rage and aggression and they propose that:

Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter, may be critical in the neurochemical control of aggressive behavior.

They share that the prescription medication called Tiagabine, a selective GABA reuptake inhibitor (SGRI), increases synaptic GABA availability.

And that 20 out of 36 patients aged 15-54 years (69%)

with symptoms of rage, aggression, or anxiety in association with one or more of the following disorders: bipolar, intermittent explosive, major depression, panic disorder, attention deficit hyperactivity disorder, or substance abuse …demonstrated a good or excellent response to tiagabine, with reduction or elimination of the symptoms of rage, aggression, or anxiety.

This and the few studies on anger and glutamate (like this one) offer the most plausible explanations for the quick results we expect when using GABA and other amino acids i.e. quick as in results in 1-30 minutes.

Other than this there is not much direct evidence supporting this GABA-rage connection. GABA likely also helps quickly because of reduced anxiety, improved sleep, and being easil able to quit or eat less sugar (and in adults quit alcohol).

Based on some research I’ve found and my experience with GABA, I suspect GABA may also help in these ways over a longer period: countering a histamine reaction, reducing inflammation and impacting cytokines, improving progesterone levels, beneficial impacts on the microbiome, supporting the liver and toxin removal (such as fluorides), gut healing and reducing high blood pressure. I am still digging into the research.

I thank these families for sharing their stories so we all benefit.

I also really appreciate this opportunity to learn from you – my community – and I will always strive to keep an open mind.

Resources if you are new to using amino acids as supplements

If you are new to using amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the symptoms of neurotransmitter imbalances, including low GABA and low serotonin).

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs. You can find them all in my online store.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support. Another option is the budget-friendly GABA QuickStart Homestudy program.

[The 19 year old young man/his mother were part of an earlier version of the GABA Quickstart program].

If you also need serotonin support, the Serotonin QuickStart Program is a good place to get help. This is also a paid online/virtual group program where you get my guidance on using tryptophan and 5-HTP safely, and community support during 5 LIVE Q&A calls. You can sign up to be notified when the next live launch of this program is happening.

Now I’d love to hear from you ….

Has GABA helped you or your child with symptoms of anger, rage or a dark mood? And if yes, how did it help, how much helped and which product helped?

Can you be sure GABA helped i.e. is this the only change you made?

Has serotonin support with tryptophan or 5-HTP also helped? And if yes how would you describe the low serotonin anger symptoms vs the low GABA anger symptoms? Are they different?

If you are a practitioner, have you observed any of the above?

Feel free to post your feedback and questions here in the comments.

Pathological Demand Avoidance (PDA) in children with autism – how much is behavioral and how much is due to low serotonin?

June 9, 2023 By Trudy Scott 14 Comments

Pathological Demand Avoidance (PDA) is a condition associated with Autism Spectrum Disorder (ASD). It is a rare behavioral phenotype of ASD that is characterized by an overwhelming or obsessional need to resist or avoid demands, which can often lead to sensory overwhelm causing meltdowns and violent outbursts.

Although children in general may often try to avoid demands, children with PDA engage in avoidant behaviors at a greater level.

The key underlying factor is the extreme levels of anxiety associated with a loss of control, which can feel like a panic attack. Because of high levels of anxiety, they will often respond with a “No” even to tasks or activities that they normally enjoy and can spend a great deal of energy trying to gain control of situations and people.

(from an Australian PDA article: What is Pathological Demand Avoidance (PDA) and how can we address it? so I changed the spelling of behavioural and characterised to be American)

This is a typical overview of PDA and the common recommendations (as outlined in the above article) are all behavioral interventions: be an active listener and build trust, depersonalize requests, provide indirect praise, use humor and so on. Many parents find these helpful but the biochemical imbalances that trigger these behaviors are being ignored and/or there is a lack of awareness. I’d like to change this so more children and teens get quick relief.

There may be many different root causes such as low serotonin, low GABA, low blood sugar, gluten sensitivities, low zinc, low vitamin B6, low vitamin D, toxins, infections, phenols, salicylates etc. Today I’m going to discuss low serotonin and my rationale for reaching this conclusion. It’s also one of the quickest root causes to confirm (more on that below).

My rationale for proposing that Pathological Demand Avoidance (PDA) in children with autism is related to low serotonin

If we take the description above, all of these symptoms are classically found when a child (or adult) has low serotonin:

Extreme levels of anxiety
Can feel like a panic attack
Overwhelm
Meltdowns and violent outbursts
Loss of control
Spending a great deal of energy trying to gain control of situations and people (i.e. controlling)
Obsessional need to resist (any kind of obsessing is common when serotonin is low)

The second reason I suspect low serotonin with PDA is the timing of these behaviors i.e. later in the day. The article mentions that “A child with PDA can be very calm, cool and compliant at school and behave much worse at home. This is not because of incompetent parenting but because they have reached their tolerance levels and need to release that suppressed anxiety.”

This may well be a factor, however low serotonin symptoms are recognized as being more severe in the afternoon/evening when serotonin levels start to decline. If these children have low serotonin then it makes sense that these symptoms would start to increase once they get home.

My third reason is that low serotonin is common in autism/autism spectrum disorder (ASD).

Low serotonin is common in autism/autism spectrum disorder (ASD)

This paper, Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism, summarizes it as follows: “The disruption of the serotonergic system is one of the most consistent observations associated with autism. Serotonin in the brain promotes prosocial behavior and correct assessment of emotional social cues.”

Their recommendations are vitamin D and tryptophan supplementation which they say “may be a simple method of increasing brain serotonin without negative side effects.”

Testing for low levels of vitamin D and supplementing accordingly is important.

Are there other low serotonin symptoms and using a trial of tryptophan to confirm

As mentioned above, low serotonin is also one of the quickest root causes to confirm. As always, regardless of the diagnosis, we assess for low serotonin by rating symptoms on a scale of 1 to 10 (with 10 being most severe) and do a trial of tryptophan (chewed or a capsule opened on to the tongue). You will have your answer very quickly because we rate improvements in symptoms in the next 5 to 30 minutes.

In addition to the above symptoms we also look for these: worry-in-your-head and ruminating type of anxiety, phobias, lack of confidence, depression, negativity, imposter syndrome, PMS, irritability, insomnia and afternoon/evening cravings for carbs and sugar.

Lidtke is the only brand of tryptophan that I recommend simply because I see it work so well and because of quality issues with tryptophan in the past. Here are the Lidtke tryptophan products I recommend:

Lidtke Chewable Tryptophan 100 mg is a good for doing a trial and works when lower doses are needed as with children.
Lidtke Tryptophan 500 mg can be used for doing a trial. I open the capsule and use 100mg for a child. Going forward this product is helpful when higher doses are needed, especially at night. When opened it doesn’t taste very good but can be mixed with inositol or even glutamine powder or mashed banana.

You can read more on this blog: Tryptophan for the worry-in-your-head and ruminating type of anxiety, see the full list of low serotonin symptoms here and find the tryptophan products on the supplements blog here.

If you’re new to PDA, the DSM and low serotonin/other biochemical factors

Professor Elizabeth Newson was a developmental psychologist known for her work with children in the autism spectrum. This is her 2003 paper on the topic – Pathological demand avoidance syndrome: a necessary distinction within the pervasive developmental disorders

It’s not part of the DSM-5, the standard classification of mental disorders used by mental health professionals in the United States. This article, A Brief History of Pathological Demand Avoidance, offers a good backstory and shares why families want it to be part of the DSM.

Whether or not it becomes a distinct condition or autism subtype in the DSM, I’d like to see low serotonin (and likely low vitamin D) being recognized as one root cause. And acknowledging that there may be many other biochemical/nutritional approaches that should also be explored.

These symptoms are listed in the above article, in addition to avoidance behaviors, and all could fall into typical low serotonin symptoms:

verbal and physical aggression when feeling loss of control
self-injurious behavior
property destruction
refusal to participate in self-care such as bathing or brushing teeth (is this depression?)
inability to attend social events (is this fear and social anxiety?)
controlling what noises are allowed in a home, such as no music, or only certain music
inability to allow parents to have friends visit the home (is this also controlling?)
are often combative with siblings
issues with food, what to eat, when to eat, who to eat with
conflict with siblings

As mentioned above we also look into low GABA and low blood sugar (trials of GABA and glutamine will give quick confirmation too), gluten sensitivity, low zinc, low vitamin B6, toxins, infections, phenols, salicylates and so on. Of course, Nutritional and Dietary Intervention for Autism Spectrum Disorder is crucial.

Some success stories and connecting the dots with low serotonin

These two success stories illustrate how successful tryptophan and GABA can be and also how quickly they offer relief:

This blog post illustrates similar low serotonin symptoms and end-of-the-day timing in adults with Alzheimer’s – Sundowning in Alzheimer’s and dementia: melatonin/tryptophan for the agitation, restlessness, anxiety, disturbed sleep and aggression. It’s low serotonin that is the cause, regardless of the diagnosis.

This blog illustrates another mechanism for these types of disruptive behaviors: Christmas tree phenols as a trigger for anger, meltdowns, anxiety, hyperactivity, insomnia, aggression, self-injury and autistic symptoms? There is a serotonin connection when there are phenol issues too.

Resources if you are new to using amino acids as supplements

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), if you need serotonin support, the Serotonin QuickStart Program is a good place to start. This is a paid online/virtual group program where you get my guidance on using tryptophan and 5-HTP safely, and community support during 5 LIVE Q&A calls. You can sign up to be notified when the next live launch of this program is happening. We take a deep dive into product options including Lidtke products and others if you’re not able to access Lidtke.

If you also have low GABA symptoms, the next step to get help is the GABA QuickStart Program.This is also a paid online/virtual group program where you get my guidance and community support. Another option is the budget-friendly GABA QuickStart Homestudy program.

Now I’d like to hear from you

Have you been told your child may have Pathological Demand Avoidance (PDA)? Have you only been offered behavioral change tools and how have they helped?

Has low serotonin (and other biochemistry imbalances) been discussed too?

What symptoms does your child have and are things worse later in the day?

Has tryptophan helped reduce the above low serotonin symptoms in your child? How much helps and how quickly?

Or do you find 5-HTP works better? If yes, how much helps and how quickly?

What other biochemical changes have helped?

If you’re a practitioner, are you hearing about increased discussion of Pathological Demand Avoidance (PDA) and do you address low serotonin with your clients/patients?

Feel free to post your feedback and questions here in the comments.

Would using 5-HTP or tryptophan help when you crave sugar (as a sort of antidepressant) late afternoon/evening?

June 2, 2023 By Trudy Scott 29 Comments

Would using 5-HTP or tryptophan also help when you crave sugar (as a sort of antidepressant) late afternoon/evening? ~ Kimberley

This question was posed in response to my recent blog post about using tryptophan or 5-HTP to help with alcohol cravings/addiction in the late afternoon/evening – to help you wind down and relax, improve mood and sleep, and also as a reward/treat.

I said yes it is often the same cause when it happens late afternoon/evening and when there are other low serotonin symptoms like low mood, anxiety, worry, insomnia etc. When serotonin is low we self-medicate with wine, sugar, carbs, gluten, dairy and chocolate etc. in order to feel good, get a mood boost and reduce stress. 5-HTP or tryptophan stops the sugar cravings, acts as an antidepressant (improving mood) and eases other low serotonin symptoms too.

It turns out Kimberley was craving sugar late afternoon: “it’s definitely late afternoon for me, while I’m making dinner. Maybe it’s time to go back on 5-HTP.”

And then 2 days later she posted how quickly 5-HTP helped when she added it back mid-afternoon:

I was taking a break from tryptophan/5-HTP and realized after reading this post that that might be a mistake! So I added 5-HTP back in mid-afternoon and my sugar cravings are almost completely gone. It’s funny how I forget the symptoms of low neurotransmitters. Thanks for reminding me!

5-HTP works quickly when it’s low serotonin

How wonderful are these results for Kimberley. I never get tired of hearing feedback like this! I appreciate her sharing and giving me permission to share as a blog so you get to learn and be inspired too.

It’s not unusual for 5-HTP to work this quickly and when it does it’s a clue that the symptoms are related to low serotonin and that she found the ideal dose for her needs.

Kimberley had good results with 5-HTP in the past so she went back to what had worked for her before and it worked for her again.

But do keep in mind, some folks do better with 5-HTP and some do better with tryptophan so it’s a matter of doing a trial of each one each.

50 mg 5-HTP: the sadness and despair lifts in a few minutes

A week later she kindly came and shared additional details in the comments of the tryptophan/ 5-HTP alcohol cravings blog, saying:

It’s possible that I was already in the middle of my daily, mid-afternoon chocolate chip binge when I saw your post

I took a 50 mg 5-HTP along with my mid-afternoon Endorphigen capsule, and within just a few minutes I felt the sadness and despair that I often feel in the late afternoon, start to lift. I was astonished at how quickly it worked! I didn’t open the capsule, or chew it, I just swallowed it with water and had a snack afterwards. I really can’t thank you enough for asking that question because I was really struggling with low mood and sadness almost every day.

Even though KImberley had used 5-HTP with success in the past, she was still astonished how quickly it worked and how effective it was. She was also surprised she had forgotten her prior low serotonin symptoms:

Up until January I had taken 5-HTP in the mid-afternoon and then Tryptophan at bedtime, but I wanted to try a program to support my thyroid. That program told me that too much serotonin is often at the root of gut damage, so I weaned myself off of the 5-HTP and tryptophan. I didn’t really notice much difference, except the daily sugar cravings.

I’m not sure how I could so easily forget the symptoms of low serotonin, but I did.

Your question really was a God-send for me, Trudy. It reminded me that there was an option for feeling better (in fact, MUCH better than sugar makes me feel) that didn’t involve something that’s not good for me.

And I really did feel remarkably better the same day, and those results have continued.

Thanks again, Trudy, for continuing to bring these topics up. Some of us are forgetful and need reminding. Usually, when you have symptoms of low serotonin there are enough other issues going on in your life that it’s easy to overlook the obvious. So I’m very grateful that you asked the question, because I feel so much better able to deal with my circumstances now that I’m back on the 5-HTP. Blessings to you!

I am curious about the program that told her too much serotonin is often at the root of gut damage and if they suggested stopping 5-HTP and tryptophan. It doesn’t make any sense to me. I’ll report back when I learn more about this.

More tired during the day and a headache: what to consider

She did mention “I’m finding myself more tired during the day and have also had a headache for the last few days.” I would suspect chocolate/caffeine withdrawal may have caused her headache.

With feeling more tired I’d also watch the dose of 5-HTP. She may find less is better for her needs.

She is also trying tryptophan at bedtime so that may be making her more tired the next day. Doing one amino acid at a time is often the best way to know how each one is affecting you.

Finding what works for your unique needs

Here are some other amino acid/sugar cravings blog posts that illustrate how we all have unique needs and different biochemical imbalances:

The individual amino acids glutamine, GABA, tryptophan (or 5-HTP), DPA and tyrosine are powerful for eliminating sugar cravings, often within 5 minutes

The individual amino acids glutamine, GABA, tryptophan (or 5-HTP), DPA and tyrosine are powerful for eliminating sugar cravings, often within 5 minutes. It seems that this wonderful benefit – over and above the anxiety-reducing and mood-boosting benefits – is often overlooked or poorly understood.

GABA for ending sugar cravings (and anxiety and insomnia)

For Melissa, an unexpected result was that she stopped craving sugar (chocolates, ice cream and truffles) after about a week of taking GABA for her travel anxiety.

It’s a matter of finding what works for your sugar cravings and unique needs. GABA worked for Melissa and yet 5-HTP works for Kimberley – for their sugar cravings.

Here is the tryptophan/5-HTP alcohol cravings blog that started the discussion: Tryptophan had the added benefit of turning me completely off alcohol when I took it to improve mood and sleep during perimenopause. In this case, tryptophan helped Victoria quit the wine that she was self-medicating with in order to feel good and relax.

Resources if you are new to using amino acids as supplements

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues.

Has 5-HTP helped reduce your cravings and/or feelings of despair and sadness? How much helps and how quickly?

Or do you find tryptophan works better for you? If yes, how much helps and how quickly?

What sugary food/s do you self-medicate with in order to feel good?

If you’re a practitioner, do you use this approach with your clients/patients?

Feel free to post your feedback and questions here in the comments.

“I’m In An Abusive Relationship That I Will Never Walk Away From”: tryptophan, a gluten-free diet, lithium and other nutritional solutions

March 10, 2023 By Trudy Scott 16 Comments

This mom’s story really struck a nerve for me… “I’m in an abusive relationship that I will never walk away from.” She shares this …

I can’t exactly pinpoint when I first felt the shift between our dynamic. One minute, things were as they always were. Before I could blink, though, I found myself engrossed in an alternate reality that resembled less and less of life as I knew it with each passing week. Trickles of rage and anger bubbled to the surface, threatening to break through until they could no longer be harnessed. I’ve been riding the waves ever since.

I currently exist in a heightened state of fear and anxiety, unsure of what each day will bring. When I wake each morning, I silently hope that today will be a “good” day; that he won’t be angry. That he won’t hurt me. Sometimes I’m lucky, and I get my person back. Other times, it feels like I’m living in a battle ground.

Her story really struck a nerve for me because of what she is going through but also because NO solutions are provided for her son. Stories like this help create awareness, make you feel less alone, create empathy and better understanding – which is important – but we want to offer nutritional solutions to families who are dealing with this.

(You can read her entire story on the ScaryMommy blog.)

Functional medicine and nutritional psychiatry as a solution

My heart goes out to this mom, this young man and the rest of the family. My hope is that this mom and all mom’s in similar situations are open to functional medicine, nutritional psychiatry and the power of food and nutrients to dramatically reduce and in many cases reverse behavioral issues like this in the child.

Sugar, caffeine and junk food must go and a gluten-free diet will very possibly make a difference. Having her son eat for blood sugar control is key too. It may also mean switching to a low-salicylate and/or, low-oxalate and low histamine diet. And addressing low lithium, low zinc, low vitamin D, low vitamin B12, high copper, low magnesium and/or low vitamin B6. Low serotonin and low GABA are common and this is where I would start with this young man (more on this below). They may also need to address his gut health/parasites, infections (like Lyme), PANS/PANDAS, mold toxicity, metals and environmental toxins etc.

I’ll highlight many of these in this blog and share links for further reading, plus the approaches I may consider. The important thing to recognize is that there is not one-size-fits-all.

Address low serotonin and low GABA

For a mom in the midst of all this, it can seem overwhelming and very daunting but when you start by addressing low serotonin and low GABA it becomes so much easier. Her son gets some relief very quickly and all the root causes can be figured out and addressed one by one. It also gives mom and the family a much-needed glimmer of hope. As I mentioned above, this is where I would start.

These are clues from her story as to why we’d want to look into and address low serotonin: her son’s explosive anger and rage, the physical and mental abuse, threats to hurt himself (self-harm) and his mother and siblings, and being argumentative.

You can see how the above fits into the list of low serotonin symptoms here. The amino acid that addresses low serotonin is tryptophan or 5-HTP and you can expect to see results in a few days.

I worked with an 11 year old girl with explosive rage issues (and anxiety, cravings & insomnia) and chewable tryptophan started to turn things around very quickly. You can read more about this here.

If he has low GABA symptoms of physical tension and anxiety, we’d do a trial of GABA next.

A gluten-free diet and eating for blood sugar control

The next change I’d make is to have him start to make dietary changes, starting to switch to gluten-free eating and real whole food. As you can see from the above blog, a gluten-free diet and getting the 11 year old off the sugar made a big difference too. Tryptophan helped with this process, making it easy to break the addiction and not feel deprived.

Gluten issues (celiac disease and gluten sensitivity) are typically associated with gut issues but the psychiatric symptoms are less recognized. This 2023 paper, Psychiatric and Neurological Manifestations of Celiac Disease in Adults states that “Celiac disease is associated with mood disorders, such as manic-depressive disease, schizophrenia, and bipolar disorder, as well as other disorders such as depression and anxiety.”

In this blog I share how gluten was found to be the cause of a childhood case of obsessive-compulsive disorder. Symptoms resolved on a gluten-free diet.

Having him starting to eat for blood sugar stability may help with the irritability and mood swings, and may also help with his rageful outbursts.

Low dose lithium orotate for the rollercoaster of emotions

Next I’d likely explore the possibility of low dose lithium orotate as something that may help this young man too. The hallmark of low lithium is a rollercoaster of emotions and this mom shares how there are really good times amongst the really tough times. I use this lithium questionnaire with clients. In addition to the ups and downs, these are clues that he may benefit: he’s rebellious, exhibits disruptive behavior and aggressiveness, is irritable, restless and engages in risky behavior.

Next steps: explore all the possible root causes and do nutritional testing

We’d want to explore all possible root causes and next steps would be decided based on his specific situation. Here is a list of 60+ root causes that I work through and the nutritional/functional testing that I do with my clients. You can replace anxiety with anger/rage in the blogs – for some people their symptoms show up as rage and for others it’s anxiety.

And here are some links for further reading:

Bartonella infection in mom and both sons: anxiety, panic attacks, insomnia, inconsolable crying, irritability, ADHD, rage and pain
Christmas tree phenols as a trigger for anger, meltdowns, anxiety, hyperactivity, insomnia, aggression, self-injury and autistic symptoms? (dietary salicylates – a type of phenol – can cause similar issues)
Sex and Aggression Characteristics in a Cohort of Patients with Pediatric Acute-Onset Neuropsychiatric Syndrome “Among patients with PANS, males exhibit more aggressive behavior when compared with females” (typically the clue it may be PANDAS/PANS is sudden onset of symptoms, although it’s not the case in all instances)
Neuropsychiatric Lyme Disease by Dr. Suruchi Chandra Lyme disease “can remain dormant for years and then later mimic a number of psychiatric illnesses, including anxiety disorders, mood disturbances, psychosis, and autism-like behaviors.”

This is not a conclusive list but a good start for seeing what the possibilities may be. Feel free to search the blog for more on some of the above and some of the other factors mentioned above and in the 60+ root causes blog.

As you can see above, we start with the simple changes – amino acids and a few simple dietary changes (all covered in my book) and lithium orotate – and then continue to dig deeper.

Mom and the other children need nutritional/trauma support too

This mom and the other children need support too – from family and community, from a therapist who specializes in trauma – and with GABA/tryptophan, adrenal support and B vitamins. You can read more about nutritional solutions for psychological stress here.

Resources if you are new to using tryptophan or GABA as supplements

If you are new to using tryptophan or GABA as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the symptoms of neurotransmitter imbalances, including low GABA and low serotonin).

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues (which include rage/anger/irritability/self-harm).

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support.

Have you found tryptophan, GABA and/or lithium orotate to help in a situation like this?

What about a gluten-free diet and eating for blood sugar control?

What bigger root causes were found to be contributing factors too?

If you have questions and other feedback please share it here too.