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Anxiety and the adrenals: low zinc and high copper

October 31, 2016 By Trudy Scott 23 Comments

two-girls

Anxiety, feelings of constant overwhelm and fatigue, plus insomnia, sugar cravings, the inability to control blood sugar, lack of mental clarity… these symptoms can be due to adrenal issues and this condition is brutally disruptive. And yes, you can suffer from all of the above at once!

In just a few weeks, from November 7-12, my colleague and good friend, NY Times bestselling author Dr. Alan Christianson will be hosting The Adrenal Reset Summit. It’s co-hosted by nutritionist Evan Brand.

I cover the Adrenals and Anxiety in my interview with Dr. Christianson and a few of the aspects we cover are low zinc and high copper.  

Here is a snippet from me about zinc:

zinc is very underrated as being a nutrient that is commonly deficient and certainly when it comes to anxiety, it’s a huge factor. We have the zinc-copper imbalance and when we’ve got very high copper levels and low zinc levels, we may feel more anxious. But zinc is really, really important for so many things. I just mentioned serotonin, it’s really important as a cofactor for making serotonin and the other neurotransmitters like GABA which is a calming neurotransmitter.

It’s really, really important for adrenal function as well. There was actually a really nice paper that was published in December 2015 [Effects of Physical Activity on Trace Elements and Depression Related Biomarkers in Children and Adolescents], looking at children and adolescents and found that children and adolescents with lower levels of zinc also had low serotonin, they had high copper levels, and they also had lower cortisol levels, and sometimes, they had high cortisol levels. So, it varies but they definitely have issues with their cortisol levels and that’s obviously going to be a big factor when it comes to how they’re able to handle stress, what their mood levels are going to be like, what their cognitive function is going to be like, and everything else. So, zinc is a really important thing. It’s not talked about a lot and it’s something that is definitely a big factor.

I didn’t share this specific information during the interview but here are some of the results from the above study:

Older children, especially girls, had higher levels of depression. Participants with moderate and severe depression had significantly lower physical activity, serotonin, and zinc levels, zinc/copper ratios, and significantly higher copper and cortisol levels.

Physically active boys showed significantly lower depressive scores and improvement in cortisol, serotonin, copper, and zinc concentrations compared to girls of sedentary life style.

A little later in the interview Dr. Christianson shares what happened to him when he was inadvertently exposed to high levels of copper:

This is a brief insight I won’t go too far into but there was a period of time I was studying with a Vedic practitioner and there were these various rituals that I had to do. One of them was involving putting liquids in these containers and drinking and doing [some of these] meditations. The historical vessels [that] were used were copper-based and I got pretty toxic at one point. I had these horrible leg cramps. I really lost my capacity for exercise. It was very dramatic. I had a hard time climbing stairs and odd mood changes and odd twitches and what not. I finally realized that was the culprit and yeah, I did mega doses of zinc which I normally would not have tolerated well but I did fine with during that time and recovered from that. So, those are a real thing! (laughs)

adrenal-reset-summit

I hope you can join us for the summit! The line-up is excellent. Here are a few of the many excellent speakers and their topics:

  • Chris Kresser, M.S., L.Ac – Is Adrenal Fatigue Real?
  • Steph Gadreau, CHNP – Perfectionism and Adrenals
  • Aviva Romm, MD – Adrenal Adaptogens
  • Ben Lynch, ND – Adrenals and Methylation
  • Wendy Myers, FDN, CHHC – Heavy Metal Toxicity
  • Dan Kalish, DC – Adrenal Neurotransmitter Connection
  • JJ Virgin, CNS, CHFS – Preventing Adrenal Burnout
  • Julia Ross, MA – Neurotransmitters and the Food Mood Connection

You can register here https://uo178.isrefer.com/go/arsScott/trudyscottcn/

Filed Under: Adrenals, Events Tagged With: anxiety, breast cancer, DCIS, detoxification, endocrine disruptors, estrogen dominance, fear, GABA, glutathione, liver support, Prevention, Thermography, toxins, tryptophan

Breast cancer: DCIS, thermography, estrogen, toxins, glutathione and anxiety

October 28, 2016 By Trudy Scott 5 Comments

breast-exam

October is Breast Cancer Awareness month so I’ve gathered some wonderful information and resources for you about DCIS, thermography, prevention by addressing estrogen dominance, avoiding endocrine disruptors and environmental pollutants and finally how to boost glutathione for detoxification support.  

Ductal carcinoma in situ/DCIS: many don’t even consider this cancer

My good friend and fellow nutritionist Robin Nielsen recently posted about this on Facebook and because it was so beautifully said, I asked if I could share it:    

A neighbor just told me this morning that she had a double mastectomy in early August due to cancer, stage 0. And then she told me it was “Ductal carcinoma in situ”. I know many women who have reversed this by changing their diet and lifestyle. This is a touchy subject for many, but it breaks my heart to see women removing their breasts when there’s a chance they don’t have to.

If you are in the thick of this right now, trying to decide what to do, do your research. Get lots of opinions from integrative practitioners. Many don’t even consider this cancer.

And if you’ve had this done yourself, you made the right choice. Because whatever we decide for ourselves is right. Sending love out to all women who have had to make this decision.

I asked Robin to share one of her articles and here it is: What You Need to Know About Your Beautiful Breasts and Breast Cancer. These factors have a big impact on our beautiful breasts:

  • The food you eat: inflammatory vs. anti-inflammatory
  • The quality and quantity of sleep
  • The toxins you’re exposed to: environmental, body care and household products, poor quality foods, toxic people, toxic habits and more
  • Your perception of stress and our ability to manage the stress in our lives
  • Your thoughts
  • And other lifestyle factors like exercise, relationships, your sense of community, etc.
  • How you deal with your emotions – your ability to express yourself
  • Your body’s nutrient status – especially Vitamin D3
  • Your ability to restore, nourish and love yourself, i.e. learning how to receive
  • The bras you wear – studies have shown that wearing a bra that’s too tight can restrict vital blood flow and can contribute to toxin build-up in your lymphatic system

Thermography for early detection and accurate test results

A thermogram image (from http://earlybreastscreen.com/)

Here are The Best Breast Cancer Screening Tests – 6 Reasons Why I Recommend Thermography from Dr. Christiane Northrup, M.D.’s blog:

  1. Good for young, dense breasts and implants. Younger breasts tend to be denser. Thermography doesn’t identify fibrocystic tissue, breast implants, or scars as needing further investigation.
  2.  Detect cell changes in arm pit area. The arm pit area is an area that mammography isn’t always good at screening.
  3.  Great additional test. Thermography can be used as an additional test to help women and their care teams make more informed treatment decisions.
  4.  It Doesn’t Hurt. The pressure of a mammogram machine is equivalent to putting a 50-pound weight on your breast, which can be quite painful for most women.
  5.  No radiation. Another reason the United States Preventative Services Task Force reversed its aggressive mammogram guidelines was because of the exposure to radiation. It’s well known that excessive doses of radiation can increase your risk of cancer. It’s ironic that the test women are using for prevention may be causing the very problem they’re trying to avoid in the first place! And this doesn’t even touch on the harm done to the body from unnecessary biopsies, lumpectomies, mastectomies, chemotherapy, radiation treatment, and so forth.
  6. Thermography is very safe. Thermography is even safe for pregnant and nursing women! It’s merely an image of the heat of your body.

Estrogen dominance as a cause of breast cancer and how to prevent it by eating for hormonal balance

breast-cancer-prevention

Magdalena Wszelaki, founder of Hormones Balance, shares some signs of estrogen dominance as the leading cause of breast cancer: Breast Lumps? Thyroid Nodules? Horrendous PMS? Endometriosis? In her wonderful article: The Breast Cancer and Estrogen Link | 15 Ways to Prevent and Manage Breast Cancer Naturally, she covers how to move from fear to empowerment and prevention by eating for hormonal balance. The article covers estrogen dominance in detail addressing:

  • Most Breast Cancers are not Genetic
  • How Breast Cancer Forms and Multiplies
  • How Estrogen Feeds Cancer
  • Signs of Estrogen Dominance (ED)
  • Not All Estrogens Are Bad

But the big takeaway is that as Magdalena says:

You have more power over your risk of breast cancer than you think. There are many steps you can take to protect yourself. Each one of them has other positive domino effects for your hormonal balance and overall health.

She shares how to rotate seeds into your diet to balance hormone levels, how to increase cruciferous vegetables like kale, broccoli, cauliflower and cabbage and how to love your liver. Here are some of Magdalena’s tips for supporting your liver which she calls the “Estrogen Detox Ally”:

A sluggish liver does not carry out its important job of filtering toxins, chemical byproducts and hormonal metabolites from your body. This can leave you with high circulating levels of the dangerous estrogen metabolites. For Breast Protection:

  • Add bitters in the form of dandelion leaves and root, burdock, chicory root, parsley, radicchio or bitters in tincture form. They stimulate bile production which then helps “flush out” estrogen and other steroid hormones.
  • Add fiber, my favorite being 2 tablespoons of freshly ground golden flax seed. Fiber promotes good bowel movement which is essential in carrying out the toxic estrogens. Chronic constipation can contribute to the re-absorption of antagonistic estrogens back to the blood stream.
  • Add one tablespoon of apple cider vinegar or half a lemon to a glass of warm water and drink it before breakfast in the morning. This helps stimulate the gallbladder to release the bile which is instrumental in “flushing out” estrogen.

Be sure to read the entire article here to read more about gut health, red meat, wine, toxins, inflammation, exercise, smoking, the birth control pill (I also covered this and FAM in a recent blog on the connection to subsequent SSRI use), sleep and finally stress and cuddling!

If you want to learn more I encourage you to check out Magdalena’s no-cost “How to Use Food To Rebalance Your Hormones” Online Workshop.

cooking-for-balance

Avoiding endocrine disruptors and environmental pollutants

My friend and colleague Dr. Heather Paulson is the author of the soon to be released Textbook of Naturopathic Oncology. She is board certified in naturopathic oncology providing expert cancer care while creating a plan that restores health. She integrates her specialization in cancer and her love of nutrition, herbs, homeopathy, counseling, traditional healing, and current research to support you during your cancer journey and for cancer prevention. Dr. Paulson shares this about avoiding endocrine disruptors and environmental pollutants:

Endocrine disruptors are things in our environment that influence our hormonal system. You have probably heard about how plastics have been causing young boys to have feminine breasts. This plastic phenomenon is due to plastic disrupting the endocrine (or hormonal) system in boys. But the endocrine effects of environmental pollutants impacts both men and women. Some of the most common endocrine disruptors you are coming on contact with include plastic, pesticides, fragrances, beauty products, and cleaning products. Eliminating these from your personal environment is a critical piece of cancer prevention that is often missed.

She created this quiz How Toxic Is Your Home to help you see how well you are doing with endocrine disruptors. You can also find several checklists on her website to help you eliminate the necessary chemicals from your kitchen, yard, bedroom, and bathroom.

Boost glutathione levels to support the body’s detoxification channels

green-asparagus

 

And finally, my friend and colleague (and fellow South African) Kirsten Nussgruber shares the importance of reducing the toxic burden. When faced with the biggest challenge of her life – being diagnosed with aggressive breast cancer twice within a short three year period – Kirsten was forced to completely reevaluate what she believed was already a healthy lifestyle and now advocate for:

  • Eating clean and real food
  • Applying clean cosmetics and skin care products
  • And supporting the body’s detoxification channels

Kirsten shares the role of glutathione and ways to support body’s detoxification channels by boosting glutathione levels, often called your master detoxifier.

In its role as detoxifier it plays a crucial role in helping the body bind and get rid of many environmental toxins such as herbicides, pesticides, fungicides, insecticides, solvents, dyes, plastics, detergents and nitrosamines often found in processed foods.

Glutathione is also known to be cancer-preventing and has been found deficient in cancer patients. It can strengthen natural killer cells, a part of your immune system you want to have ready for action at all times!

In her blog post, she covers glutathione supplementation and shares a list of whole foods that boost glutathione production:
asparagus, acornsquash, avocados, broccoli, cabbage, cantaloupe, garlic, grapefruit, leeks, okra, onions, oranges, peaches, potatoes, spinach, strawberries, tomatoes, walnuts, watermelon, and zucchini.

Don’t be driven by fear and anxiety

As I said in my 2013 Breast Cancer Awareness blog: don’t be driven by fear and anxiety, instead use these wonderful resources as tools so you can be proactive and prevent breast cancer.

If you do get to a place where the anxiety and fear becomes overwhelming, don’t forget about the targeted individual amino acids like GABA and tryptophan for eliminating the anxiety and worry, obsessive thinking, negative self-talk, insomnia and overwhelm.

Here’s to beautiful healthy breasts for you and every woman!

Filed Under: Women's health Tagged With: anxiety, breast cancer, DCIS, detoxification, endocrine disruptors, estrogen dominance, fear, GABA, glutathione, liver support, Prevention, Thermography, toxins, tryptophan

DPA to end comfort-eating, end weepiness and boost endorphins

September 10, 2016 By Trudy Scott 83 Comments

medicinal-supplements-summit-speakers

The Medicinal Supplements Summit runs September 12 -19 and is dedicated to helping you learn the latest in supplement customization to boost energy, lose weight, beat stress, improve brain function and heal your body! 

My interview addresses amino acids for both anxiety and depression – I talk about GABA, tryptophan, 5-HTP (and when not to use it), DPA, glutamine and tyrosine.

medicinal-supplements-summit-day6

Wendy asks me to share more about DPA for the low endorphins kind of depression, comfort eating, emotional pain, weepiness and physical pain. Here are some snippets on this topic from my interview:

DPA is D-phenylalanine. It’s an amino acid that actually destroys the enzyme that breaks down endorphins. Endorphins are feel-good chemicals that we may relate to when you hear about getting an endorphin rush, when you go for a run or when someone gives you a big hug or when you do something nice for someone or someone does something nice for you, you get that nice sort of feel good feeling, like you’ve got this big hug kind of feeling. So taking this amino acid, DPA, helps, in essence, to raise your endorphins.

There are different kinds of depression. I mentioned the low serotonin depression, which is more the anxiety kind of depression. With the low endorphin kind of depression, you’re very weepy. You may be overly emotional. So if you watched a TV ad or you watched a really sad movie, you may be more prone to crying than the average person. As well as being sensitive to emotional pain, which is the crying and the weepiness, you also tend to be sensitive to physical pain.

So we know that doing acupuncture raises your endorphin levels. And in that way it helps with pain. So taking this amino acid will help with that emotional sadness that you often feel when you’ve got low endorphins. And it is very, very helpful for physical pain as well. I find a number of clients with physical pain that is related to low endorphins. Pain can be related to low oxalates or nightshades, something physical, or even osteoarthritis. So you’ve got some kind of physical issue. But if it’s related to low endorphins you’ll actually see a really nice pain reduction effect from it.

Now, the big thing with low endorphins is this comfort eating. So I mentioned earlier with low serotonin you have the anxiety and the depression and the afternoon and the evening cravings. With low endorphins, as well as this emotional aspect and the pain aspect, the cravings part is very much a comfort kind of craving.

It’s like, “This is my reward. This is my treat. I deserve it.” And when you consume those carbohydrates, that bowl of ice cream, that bowl of cereal, that chocolate chip cookie, you feel like this is my reward. I deserve it. So a lot of people will resonate with the low endorphins kind of emotional eating. And when they get on DPA their mood improves, and this comfort eating goes away.

Tune in to hear my entire interview and all the other great speakers!

You can use this link to register for access: https://qt247.isrefer.com/go/SUPP16reg/trudyscottcn/

And use this link to purchase at pre-summit special prices:
https://qt247.isrefer.com/go/SUPP16order/trudyscottcn/

Filed Under: Events, GABA Tagged With: 5-HTP, aminos for anxiety, comfort eating, depression, DPA, emotional, GABA, glutamine, Medicinal supplements summit, tryptophan, tyrosine

Confused about supplements? Join me on the Medicinal Supplements Summit

August 29, 2016 By Trudy Scott 1 Comment

medical-supplement-summit-speakers

Confused about supplements? Are you they doing you more harm than good? Join me on The Medicinal Supplements Summit from September 12-19, 2016 and learn the latest in supplement customization to beat stress and end anxiety, boost energy, lose weight, improve brain function and heal your body!

Your hosts of The Medicinal Supplements Summit are Wendy Myers, an expert in detoxification and founder of Liveto110.com, and Ian Clark, founder of Activation Products.  

They both understand the importance of taking the right supplements – after all, they both healed their own health crises through targeted supplements, whole body health and the power of micronutrients!

This event is dedicated to helping you determine what you need, separate “claims” from the truth, customize to your needs and make proper decisions at the store or online.

All reasons not to miss The Medicinal Supplements Summit, online from September 12-19, 2016!

Here is the line-up of topics:

DAY 1 (September 12, after 10am US eastern)
The Medicinal Supplements Summit starts. We’ll discuss whether you need supplements to be healthy, can you get all your nutrients from food and important supplements missing from your health regime!

DAY 2 (September 13, after 10am US eastern)
On Day 2 of The Medicinal Supplements Summit, we discuss top supplements in depth: fish oil, probiotics, Vitamin C, food-based vs. synthetic supplements and minerals, like magnesium. Learn what kind of supplements you should take and how to take them!

DAY 3 (September 14, after 10am US eastern)
On Day 3 of The Medicinal Supplements Summit, we discuss tips and tests you can take to customize supplements to your body’s needs. Take the guesswork out of choosing supplements!

DAY 4 (September 15, after 10am US eastern)
Buyer beware! On day 4 of The Medicinal Supplements Summit we discuss the supplement categories that require extra scrutiny before you buy: weight loss, detox, energy, performance-enhancing and protein supplements. These supplement categories offer products that are harmful or ineffective, and should be avoided.

DAY 5 (September 16, after 10am US eastern)
On Day 5 of The Medicinal Supplements Summit, we review the top medicinal supplements for common health conditions: heart disease, pain, adrenal fatigue, thyroid dysfunction, gut health and autoimmunity. These supplements should be in your medicine cabinet!

DAY 6 (September 17, after 10am US eastern)
Day 6 at The Medicinal Supplements Summit reviews supplements for common health conditions: brain fog, depression, anxiety, digestive issues, fibromyalgia, pain and sleep disturbances.  

My interview airs on day 6: Using Amino Acids for Anxiety and Depression

  • How to find out what type of depression you have
  • Specific amino acids for your type of depression or anxiety (individual targeted amino acids: tryptophan, GABA, DPA, glutamine and tyrosine)
  • Serious complications caused by anti-anxiety medication

DAY 7 (September 18, after 10am US eastern)
On Day 7 of The Medicinal Supplements Summit, we discuss hot topics in the supplement world: toxic metals in supplements, hidden gluten, ingredients to avoid and using essential oils.

DAY 8 (September 19, after 10am US eastern)
Encore Day at The Medicinal Supplements Summit!

Here is the registration link https://qt247.isrefer.com/go/SUPP16reg/trudyscottcn/

Hope to see you there.

Filed Under: Events Tagged With: amino acids, anxiety, depression, GABA, Medicinal supplements summit, supplements, tryptophan, Wendy Myers

Tryptophan and melatonin make a big difference but why do I still wake at 4am?

August 26, 2016 By Trudy Scott 113 Comments

waking-up-early

I get many questions on the blog about problems with sleep: not able to fall asleep, not waking rested and waking in the early hours and not being able to go back to sleep. By far the most common question is “Why do I still wake at 4am and can’t go back to sleep?”

So let me share one of the typical questions I receive and my feedback in the hope that something you read here may help you or someone you’re working with. Here is the question:

I purchased Lidtke l-Tryptophan and time release melatonin and notice a big difference in my sleep. Instead of waking up every two hours I’m sleeping better but still wake up at 4 am and can’t get back to sleep. GABA hasn’t helped. What can I take to get back to sleep and what are your thoughts on Seriphos Phosphorylated Serine? I think my anxiety has to do with my adrenals because I wake up in a sweat and am way past menopause.

Since she is seeing a big difference with tryptophan and timed-release melatonin, low serotonin is the likely root cause of her insomnia or at least one of the root causes. We always want to capitalize on what is already working. Too many people don’t see expected results with 1 x 500mg tryptophan at bedtime and 1mg timed-release melatonin and start looking for other solutions when the answer may be right in front of them.

Here are the steps I’d follow with a client with similar sleep challenges:

  • Try more tryptophan, increasing it slowly over the course of a few weeks in the hope that it more will provide more serotonin support. This is what I call an amino acid trial where you rate and log your improvements as you incrementally increase – with the goal of finding an optimal amount for your needs. We all have different needs and post menopause it’s not uncommon for women to experience anxiety, depression and insomnia related to low serotonin and fluctuating sex hormones. We also always want to capitalize on what is already working.
  • Also, to add to what’s working, add tryptophan mid-afternoon if it’s not already in place. When someone scores high on the low serotonin questionnaire the typical timing of tryptophan is mid-afternoon and an hour before bed (always away from protein). Serotonin levels start to decline mid-afternoon hence the benefits of a mid-afternoon dose. Start low and increase slowly.
  • I would also suggest trying the tryptophan opened up (at both times) to see if this makes a difference.
  • Taking a tryptophan at the 4am waking can help you go back to sleep so this is worth trying. For some people 500mg at 4am is too much and using 125mg or 250mg works well. You determine the amount based on how you feel when you do get up. If you were able to go back to sleep easily buy wake groggy then it’s too much.
  • Some people are reporting better results with Lidtke Tryptophan Complete (which has all the co-factor nutrients) so this may be worth trialing too. I’d start by adding to what is already in place.
  • If we get benefits with any of the above by are not quite there then I would suggest additional timed-release melatonin until sleep improves.

This is always done slowly and methodically over the course of a few weeks. I always have my clients carefully log what they try and what is working and not working.

Other factors we’d make sure are addressed:

  • What GABA was used, was it trialed (starting low and increased) and was it used sublingually?
  • Is high cortisol at night a factor? Doing an adrenal saliva test will provide the answer. If it is then the Interplexus Seriphos is the best for lowering it. It’s best to take 1-3 x Seriphos about 2-3 hours before the high cortisol.  [UPDATE: INTERPLEXUS SERIPHOS WAS REFORMULATED IN 2016 – PLEASE SEE BELOW FOR MORE ON THIS]
  • Is gut health a factor? Look into SIBO, gluten sensitivity, other food sensitivities, dysbiosis and parasites (which are often active in the early hours and can cause night sweats)
  • Is there a sex hormone imbalance? Even with someone way past menopause, the night sweats mean this should be ruled out. The addition of amino acids starts to balance the hormones but more support may be needed.  
  • Is any caffeine (even decaf) still being consumed?
  • Is blood sugar stable? Make sure to have breakfast with animal protein and healthy fats and the same at each meal and for snacks. Consider a trial of glutamine during the day and just before bed for added blood sugar stability
  • Are medications a factor? Current medications or prior use of benzodiazepines or SSRIs can affect sleep even long after they have been tapered.
  • Is sleep apnea a factor?

We also address all the usual sleep hygiene factors: dark room, cool room, quiet room, no cell phone or clock radio on the bedside table, no late night computer use and getting some early morning light.

Many essential oils can provide added benefits when diffused at night or mixed with a carrier oil and used topically. One lovely combination I share on the Essential Oils Revolution 2 (happening now) is lavender, roman chamomile and neroli which helps both insomnia and anxiety.

There can be many other possible root causes of insomnia: autoimmunity, Lyme disease, pain, past trauma or grief and even genetic polymorphisms, all covered on the recent Sleep Success Summit.

Have you used tryptophan or other amino acids like GABA (for the more physical tension) and melatonin to reduce or eliminate early morning waking episodes?

If you’re a practitioner, have you helped your clients/patients with this methodical approach?

What else has helped you?

Update August 27, 2016 : INTERPLEXUS SERIPHOS HAS BEEN REFORMULATED -I am doing research to find suitable alternatives. For now, feel free to read through the comments below for discussions about this.  Once I have some useful information I’ll create a new blog post. 

Update November 18, 2016: Here are some possible alternatives to Seriphos

Update January 20, 2017: The Original Formula of Seriphos has been reintroduced you can read more about this here

 

Filed Under: Sleep Tagged With: amino acids, anxiety, GABA, insomnia, melatonin, seriphos, serotonin, sleep, tryptophan, waking

Tryptophan and ascorbic acid for anxiety caused by lead toxicity

August 19, 2016 By Trudy Scott 18 Comments

lead-toxicity

Lead toxicity is a factor when it comes to anxiety, panic disorder, phobias and depression, even with low levels of lead exposure.

This 2010 paper, published in the Archives of General Psychiatry, Blood lead levels and major depressive disorder, panic disorder, and generalized anxiety disorder in U.S. young adults reports the following:

In this sample of young adults with low levels of lead exposure, higher blood lead was associated with increased odds of major depression and panic disorder. Exposure to lead at levels generally considered safe could result in adverse mental health outcomes.

The paper discusses a possible mechanism of action i.e. lead disruption of neurotransmitter production (of the catecholamines and serotonin):

If lead exposure contributes to the etiology of these disorders, the mechanism of action could involve perturbation of neurochemistry, such as brain monoamine neurotransmission.

Lead exposure is known to disrupt catecholaminergic systems, and depression and anxiety disorders are strongly associated with disturbances in these systems.

Studies in animals show that chronic lead exposure can decrease serotoninergic activity in several brain regions including the nucleus accumbens, frontal cortex, and brainstem.

It is surprising that generalized anxiety disorder was not associated with increased lead levels in this study but other research does find anxiety correlations:

  • bone lead (a biomarker of cumulative lead exposure) was associated with phobic anxiety and depression among older women who are premenopausal or who consistently take postmenopausal HRT
  • blood lead concentrations were associated with increased risk of behavioral problems and anxiety in Chinese preschool children
  • bone and blood lead levels were significantly associated with an increased risk of phobic anxiety in middle-aged to elderly men

Addressing lead and other heavy metal toxicity is not to be taken lightly and can often be quite a lengthy process. Finding a knowledgeable practitioner who understands chelation is important. We covered much of this in my interview with Dr. John Dempster on season 4 of the Anxiety Summit – Anxiety and heavy metals: chelation of mercury and lead

The good news is that while you are working on lead detoxification there is promising research that supports what I see in my clients: using the amino acid tryptophan reduces and often completely eliminates anxiety, panic attacks and depression while you are dealing with other underlying issues. In this instance it’s the lead toxicity but it could also be Lyme disease or gluten sensitivity or Hashimoto’s thyroiditis and many other conditions.

The animal study I’m referring to was published at University of Lagos paper in 2012: Neurobehavioural and neurotoxic effects of L-ascorbic acid and L-tryptophan in lead exposed rats and states that:

The sub-chronic exposure to lead decreased brain serotonin, while causing oxidative stress by decreasing reduced glutathione levels, antioxidant enzyme activity and increasing lipid peroxidation and brain protein contents.

Ascorbic acid attenuated [or reduced] both lead induced neuronal oxidative stress, and abnormalities in behaviour.

Tryptophan ameliorated [or improved] lead-altered neurobehaviour [such as anxiety and aggression].

Co-administration of ascorbic acid and tryptophan on lead exposed rats showed a reversal in all indices assessed towards the physiological state of control. This suggests that ascorbic and tryptophan can be used to compliment chelating therapy in lead neurotoxicity.

I don’t know if you can extrapolate the dosages from the rat to a human weight-wise but since I have a curious mind I did some calculations: it turns out that they used a rough equivalent of 2000mg of ascorbic acid and 1000mg of tryptophan for an adult human. The starting dose for tryptophan is typically 500mg, and less if you’re sensitive or a “pixie dust” person. I would start here and do an amino acid trial, increasing over a few weeks until anxiety symptoms start to resolve. You can read more about the amino acids process here

Have you used tryptophan (or other amino acids like GABA) to reduce or improve anxiety symptoms with success, while dealing with a bigger underlying issue such as lead toxicity?

If you’re a practitioner, have you helped your clients/patients with tryptophan while dealing with lead toxicity?

Filed Under: Anxiety and panic Tagged With: amino acids, anxiety, ascorbic acid, Lead toxicity, panic attacks, Panic disorder, serotonin, tryptophan, vitamin C

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  • BeSerene™ GABA/theanine cream eases severe muscle tension in her neck/shoulders, prevents her bad headaches and quells her anxiety
  • How the correct approach, dose and sublingual use of GABA can be calming and not cause a flushed and itchy face and neck
  • The amino acid glutamine improves low mood by addressing gut health, and it has calming effects too
  • Flight anxiety with heightened breath, physical tension and also fearing the worst (the role of low GABA and low serotonin)

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