social anxiety

Can Social Anxiety Be Reversed with Nutrition?

May 29, 2015 By Trudy Scott 62 Comments

Sean Croxton host of Underground Wellness Radio shares how:

he was once prescribed Paxil for social anxiety (and depression)
he doesn’t like big crowds
he can speak on stage in front of 100s of people with no problem
as soon as people come to talk to him afterwards he wants to go!

Can you relate to any of this?

He thinks he has pyroluria, a social anxiety condition where you have a higher need for some key nutrients: zinc, vitamin B6 and evening primrose oil.

We are often surprised when we hear that someone who appears to be outgoing and extroverted (like Sean) actually has social anxiety.

It’s more common than you think and is made worse under stressful situations: life stresses, gluten sensitivities etc.

I share how my social anxiety got really bad in my late thirties (when my PMS was so bad) and how

many of us with pyroluria push through and deal with it
we just want to stay home
we don’t really want to see people

Not everyone needs omega-3 supplements!

We discuss omega-3s and omega-6s and how pyrolurics often don’t need to supplement with omega-3s like fish oils but can extract the omega-3s from the foods they eat: grass-fed red meat, wild fish like salmon, leafy greens and walnuts.

Pyrolurics often do need to supplement with the GLA form of omega-6 that we find in evening primrose oil as GLA is often low, plus the GLA enhances zinc absorption.

(by the way: I said alpha linolenic acid (ALA) but should have said gamma linolenic acid (GLA)

A good copper-free multi is part of the protocol because low zinc often means high copper and this can make you more anxious.

Looking at other sources of copper is a helpful for many pyrolurics: eating too many nuts, baking with nut flours, the copper IUD.

You don’t want to miss this part…Sean asks if you can cure introversion with this pyroluria protocol. If you are an introvert and force yourself in social settings, feel very uncomfortable and anxious being around big groups of people then you’re going to have to watch the end of the video for my answer!

You can watch the whole snippet here

This is part of my interview on the Depression Sessions, an online event hosted by my friend Sean. I’ll also be sharing information about the amazing amino acids – inexpensive, over-the-counter supplements that can lift your mood and end anxiety in minutes!

Sean traveled the country to interview the best of the best experts — medical doctors, naturopaths, nutritionists, and bestselling authors — on what really causes depression and anxiety and what to do about it.

Some of us (like me) flew to San Diego to be interviewed in his home. It was such a thrill to be interviewed by the legendary Sean Croxton and is an honor to be part of this group of experts!

Here are just a few of the amazing experts you’ll hear from:

Suzy Cohen, also known as America’s Pharmacist, uncovers specific prescription drugs that rob your body and brain of mood-friendly nutrients.

Datis Kharrazian will show you what insomnia, anxiety, and the symptoms that tag along with depression can tell you about what’s causing it.

Hyla Cass, a medical doctor and integrative psychiatrist (who has been featured on two prior Anxiety Summits), shares her best tips for transitioning OFF of psychiatric meds while avoiding or minimizing common withdrawal symptoms.

Ben Lynch (another Anxiety Summit favorite) reveals the incredibly common genetic mutation known to drive depression (and anxiety) … and the critical nutrients that make such a big difference.

Pyroluria/social anxiety protocol: why aren’t I getting results? (trouble-shooting checklist)

May 16, 2015 By Trudy Scott 118 Comments

How do you trouble-shoot when you score high on the Pyroluria Questionnaire from The Antianxiety Food Solution or even have a positive pyroluria urine test but you don’t seem to be getting the results you expect?

You still have social anxiety, that inner tension that you push through and deal with, and likely still feel uncomfortable when in large groups. You force yourself to put on the confident brave face. You may wish you could be more like your extrovert friends and actual enjoy socializing and speaking in public/on stage – without the fear and anxiety. You may still not be a big breakfast eater and have morning nausea. You may not yet be having pleasant dreams that you always remember.

(If pyroluria is new to you here is the Pyroluria Questionnaire from The Antianxiety Food Solution and here is a nice summary – Pyroluria, social anxiety, introversion: a summary )

This checklist is a starting point to try and figure out what may be the issue. These are the questions I work through with someone who is working with me one-on-one.

I discussed 21 of these in my interview on season 3 of the Anxiety Summit: Pyroluria, Amino Acids and Anxiety: Troubleshooting when you are not getting results

As you heard during the interview, I added MTHFR and I’ve even added a few more since then. I expect this list to continue to grow.

What form of zinc are you taking and is it free from copper? My favorite is Optizinc (zinc monomethionine) as it’s typically well-absorbed
Have you made sure that there is no copper in your multivitamin or other supplements? (this completes with zinc)
Have you been taking evening primrose oil and if yes, how much? (this enhances zinc absorption)
Did you test your fatty acid levels? What are the results? Did it show a need for GLA (I like evening primrose oil rather than borage oil) and no need for omega-3s (pyrolurics typically don’t need to supplement with omega-3s like fish oil)
What is your alkaline phosphatase (a blood test)? Less than 70 may indicate a need for zinc
Have you done the zinc tally/challenge with zinc sulfate and does it taste like water or does it taste really bad? If you zinc levels are good it should taste really bad
Did you test copper and ceruloplasmin, and if yes, what were the results?
Did you do the pyroluria urine test? What are the results?
What’s your score on the pyroluria questionnaire ? And which symptoms do you have?
What is your score on the introversion questionnaire?
What were your dreams like before starting the protocol and now? How high did you go on the vitamin B6? Did you switch to P5P and/or use a combination of both if needed?
On a scale of 1-10, what was your social anxiety before and now (10 is worst)
What is your stomach acid like? And have you trialed HCl supplements? Tested total protein (in blood)
Do you eat grass-fed red meat (a good source of zinc, iron and omega-3s)?
Do you eat sugar? Refined sugar and processed foods? Or even “healthy” sweeteners such as honey in large quantities? (sugar depletes zinc)
Do you eat large quantities of nuts or bake with nut flours? (the copper in the nuts may be affecting your zinc levels)
Do you have a copper IUD, copper pipes, copper pots? (this may also affect your zinc levels, keeping them low)
Have you done a hair analysis and found high copper or high hidden copper? (this may also affect your zinc levels, keeping them low)
How much and how often do you exercise? What about bikram/hot yoga? (sweating depletes us of zinc)
Have you used any of the amino acids? And seen good results? (this could be a clue that zinc and vitamin B6 are low since they are cofactors for making neurotransmitters such as serotonin, GABA, dopamine)
Do you eat gluten and have a gluten sensitivity? If yes, have you healed your gut? If not, you may have malabsorption issues
Are you completely grain-free? (this may be impacting your vitamin B6 levels)
Do you have amalgams/silver fillings? Did you have them removed and did a mercury detox? Were you tested for heavy metals? (zinc absorption can be blocked by heavy metals – we talked about this in season 2)
Do you have the MTHFR polymorphism? It’s common with pyroluria and this may mean you need higher amounts of the supplements
Do you have high histamine/hisadelia or low histamine/histapenia? Pyrolurics often have one or the other
Are you taking benzodiazapines or have recently quit benzodiazapines? Your unresolved anxiety may be due to this fact (we talked about this in season 1)
Do you have parasites, candida, dysbiosis, SIBO or other digestive issues? These can be considered stresses and pyroluria symptoms are worse under stress. Digestive issues also impact absorption
Do you have Lyme disease or another infection? These can be considered stresses and pyroluria symptoms are worse under stress. The immune system also uses up zinc.
Do you have food sensitivities? This may contribute to malabsorption. This can also be considered a stress and pyroluria symptoms are worse under stress
Do you have problems with histamine-containing foods? This can be considered a stress and pyroluria symptoms are worse under stress. Also, vitamin B6 is a co-factor needed for the DAO enzyme, which is responsible for the degradation of histamine.
Do you have issues with oxalates? This can be considered a stress and pyroluria symptoms are worse under stress. Oxalates can also bind to minerals and lower the levels. For some folks vitamin B6 helps with oxalate issues so the need may be higher.
Have you been/are you exposed to mold and other toxins? These can be considered stresses and pyroluria symptoms are worse under stress. The immune system also uses up zinc.
Do you have low oxytocin levels? Do you have a genetic variation in the oxytocin receptor gene (OXTR). Oxytocin has been implicated in anxiety, depression and related stress phenotypes
Is your life super-stressful or have you suffered from a recent trauma (or have old unresolved trauma)? Stress and trauma makes pyroluria worse
Do you have adrenal issues? We need good adrenal function for optimal digestion, being able to handle stress and being able to fight off infections/avoid getting parasites and dysbiosis
Do you have hormonal issues – PMS, perimenopausal or menopausal symptoms? The pyroluria protocol helps and this could be a clue that something is off
Are you on the birth control pill or have used one in the past? Oral contraceptives cause low vitamin B6 and zinc, reduce serotonin levels and increase anxiety.
Are you on any other prescription medications? Many medications deplete B vitamins and zinc.
Do you have vagus nerve issues? Good vagus nerve function is key for digestion, immunity, inflammation, neurotransmitter production and so much more. Also, forcing yourself to socialize when you have pyroluria is stressful and impacts the vagus nerve
Do you have inflammation and/or immunity issues? Vitamin B6 plays a role in reducing inflammation and immune modulation

[August 2021: the above list was updated extensively]

This list is NOT exhaustive and it’s NOT in my book The Antianxiety Food Solution because I gathered this information after the book was published. However, the pyroluria questionnaire, detailed protocol and testing information is in the book. There is an entire chapter on pyroluria.

Keep in mind that most folks do the pyroluria questionnaire, start on the recommended protocol of zinc, vitamin B6 and a copper-free multi and start to see improvements in a week. These can be dramatic improvements for many folks. And many folks see decent improvements in a few weeks and tweak things over the next few weeks before landing on the ideal doses.

This blog is for you if this doesn’t happen.

Did you miss this interview or want this and the other great interviews for your learning library? You can purchase the MP3s or MP3s + transcripts and listen/read when it suits you. You can find your purchasing options here: Anxiety Summit Season 1, Anxiety Summit Season 2, and Anxiety Summit Season 3.

Feel free to share your results in the blog comments and what you figured may be the issue/s for you.

If you tweak something and it helped do let us know too. That way we all help each other.

And feel free to ask questions in the comments too.

The Anxiety Summit – Pyroluria, Amino Acids and Anxiety: Troubleshooting when you are not getting results

May 16, 2015 By Trudy Scott 101 Comments

Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution. presents during the Anxiety Summit Season 3.

Pyroluria, Amino Acids and Anxiety: Troubleshooting when you are not getting results

Pyroluria and the effects of leaky gut, oxalates and low oxytocin levels
CFS, ADHD, autism, alcoholism, Lyme disease: the pyroluria connection
Introversion and musician’s dystonia: an update on the pyroluria connection
Troubleshooting the pyroluria protocol and mistakes I see
Testing for pyroluria, zinc, vitamin B6 and fatty acids
The 8 factors that make the targeted individual amino acids more effective
What to do when the amino acids are not working
Concerns about quinolinic acid and tryptophan?

Pyroluria/social anxiety/introversion protocol: trouble-shooting

This is the blog I mentioned that summarizes a number of prior blog posts on the topic: Pyroluria, social anxiety, introversion: a summary

We discussed factors to consider when you are not getting results on the pyroluria protocol. Here is the blog with the 21 we talked about during the interview plus additional factors that I’ve added.

Pyroluria protocol: why aren’t I getting results – trouble-shooting checklist

Here are the oxytocin blogs that discuss social anxiety, testing, the oxytocin receptor gene and connections to autism and depression:

Oxytocin, social anxiety, pyroluria and autism

Dr. Woeller shares how helpful oxytocin is for social anxiety, facial recognition and voice recognition in individuals with autism and Asperger’s syndrome

Oxytocin and social anxiety, pyroluria and depression?

Genetic variation in the oxytocin receptor gene (OXTR) has been implicated in anxiety, depression and related stress phenotypes

I mentioned my aminos and pyroluria interview with Sean Croxton on the upcoming Depression Sessions (an online video series) in June. He is an introvert and is fascinated with pyroluria-introversion connection. I said I’d share a link to the Depression Sessions but the site isn’t quite ready so please stay tuned. I’ll share it in a few days. This one is not to be missed.

Targeted individual amino acid supplements for anxiety: trouble-shooting

This is the blog I mentioned that summarizes a number of prior blog posts on the topic: Anxiety and targeted individual amino acid supplements: a summary

Here are the categories I discussed, together with the associated amino acid/s

low blood sugar: glutamine
low GABA: GABA (I prefer GABA to Phenibut or pharmaGABA)
low serotonin: tryptophan or 5-HTP
low endorphins: DPA (d-phenylalanine)
low catecholamines: tyrosine

Here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution. I encourage you to do and see which sections may be an issue for you (or see how much you’ve improved if you’ve been using amino acids)

I discussed why Urinary neurotransmitter testing falls short and why I use the above questionnaire instead

There are some precautions to be aware of when taking supplemental amino acids. Here are the Amino Acid Precautions

The 8 factors that make the amino acids more effective:

addressing blood sugar issues and eating real whole food
the brand and quality
timing i.e. between meals and away from protein
your unique amount for your own need
addressing bipolar or bipolar-type symptoms
using the pyroluria protocol at the same time (if needed)
addressing thyroid health and hormonal health
taking the amino acids opened up

Thanks to Dr. Josh Friedman, Integrative Psychotherapist, for the interview. As I mentioned, I interviewed him on season 1 of the Anxiety summit on: “Integrative Psychotherapy: My Journey from Psychoanalysis to Whole Person Mental Health.” If you missed it, I highly recommend it. Dr. Friedman is dear friend, colleague and integrative psychotherapist who uses amino acids and other nutritional approaches in his practice. During our season 1 interview I asked him if he uses GABA with his patients and I love his answer:

it is definitely something I use. I am not a biochemist, so I actually don’t really know whether it crosses the blood/brain barrier, nor do I care actually. the first question should be, is it harmful? Are any of these things going to cause harm? And the answer with all the amino acids are no, they’re not going to cause harm, especially when compared to psychiatric medicines. The second question is, does it work? Is it helpful for our patients that we see in our practice?

Here is a link to my book: The Antianxiety Food Solution: How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings

As we mentioned, it has the amino acid questionnaire, pyroluria questionnaire and all the protocols BUT does not contain the 21+ pyroluria touble-shooting checklist (see the separate blog post for this)

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here: www.theAnxietySummit.com

Missed this interview or can’t listen live? Or want this and the other great interviews for your learning library? Purchase the MP3s or MP3s + transcripts and listen when it suits you.

You can find your purchasing options here: Anxiety Summit Season 1, Anxiety Summit Season 2, and Anxiety Summit Season 3.

Pyroluria, social anxiety, introversion: a summary

May 8, 2015 By Trudy Scott 47 Comments

Pyroluria is a social anxiety condition that is not well recognized in the medical community. It responds really well to a few key nutrients. I cover this in this blog post: Pyroluria, high mauve, pyrrole disorder, malvaria, elevated kryptopyrroles and social anxiety

Low levels of the mineral zinc and vitamin B6 are frequently associated with a type of anxiety characterized by social anxiety, avoidance of crowds, a feeling of inner tension, and bouts of depression. People with this problem experience varying degrees of anxiety or fear, often starting in childhood, but they usually manage to cover it up and push through. They tend to build their life around one person, become more of a loner over time, have difficulty handling stress or change, and have heightened anxiety symptoms when under more stress.

This constellation of symptoms is often the result of a genetic condition called pyroluria, also known as high mauve, pyrrole disorder, pyrroluria, pyrolleuria, malvaria, and elevated kryptopyrroles.

If this sounds like you, here is a link to the Pyroluria Questionnaire from my book The Antianxiety Food Solution. I created this using the work of Carl Pfeiffer and Joan Mathews-Larson, modifying it based on feedback I received from my clients.

I encourage you to do this questionnaire and see how you score (before starting on the supplements and once you are on them).

This is a collection of past blog posts on the topic of pyroluria in preparation for my season 3 interview on the Anxiety Summit: “Pyroluria, Amino Acids and Anxiety: Troubleshooting when you are not getting results”

During the Anxiety Summit season 2 Dr Corey Schuler interviewed me on the topic: How zinc and vitamin B6 prevent pyroluria and social anxiety

I review the questionnaire, the protocol and discuss how I’ve discovered a pyroluria-introversion connection. Here is the blog post I wrote in response to the Huffington Post article, written by Carolyn Gregoire and called “23 Signs You’re Secretly An Introvert”: Am I an anxious introvert because of low zinc and vitamin B6? My response to Huffington Post blog

I encourage you to also do this questionnaire and see how you score and see if a high score correlates with a high score on the pyroluria questionnaire. Do this before starting on the supplements and then once you are on them. Many anxious introverts no longer feel anxious in social settings once they get on the pyroluria protocol. Many say they no longer see themselves as introverted!

In that season 2 interview I also share about the connection between Pyroluria and focal musician’s dystonia or musician’s cramp

Here are some more recent blogs on pyroluria and related conditions:

For most of my clients getting on the pyroluria protocol is life-changing! It certainly has been for me!

Unfortunately not everyone responds as expected. Some people:

Cannot get their zinc levels to increase
Feel too nauseas when taking any zinc
Never seem to remember their dreams
Continue to have social anxiety despite everything they do

My troubleshooting interview will be addressing the above scenarios and other related pyroluria questions that come up. PLEASE ASK YOUR QUESTIONS in the comments section below.

PS. If you’d like me to try and troubleshoot for you, please answer the questions I posed to Nancy below

If you’re not already signed up do join us here: season 3 of The Anxiety Summit

Oxytocin, social anxiety, pyroluria and autism

April 10, 2015 By Trudy Scott 11 Comments

I recently blogged about the possible connection between oxytocin, social anxiety, pyroluria and depression and would like to share that there is also a connection between autism, low oxytocin and social anxiety, and possibly pyroluria too.

It’s Autism Awareness Month so I’d like to share a video from Dr. Kurt Woeller D.O., an integrative medicine physician and biomedical autism specialist. He is also a lecturer, educator, and experienced practicing clinician offering specialized diagnostic testing and treatment for individuals with complex medical conditions like autism, mental health disorders, multiple sclerosis, and other chronic health conditions.

Dr. Woeller shares how helpful oxytocin is for social anxiety, facial recognition and voice recognition in individuals with autism and Asperger’s syndrome

An interesting therapy for certain individuals on the autism spectrum is something called oxytocin. Oxytocin is a hormone that is produced in our bodies and it has a wide range of effects. When a woman is in labor, oxytocin helps with uterine contractions so it is useful for the delivery of the baby. When a mother is breastfeeding her newborn, oxytocin can be released and it is felt that oxytocin helps with mother to child bonding that occurs with breastfeeding.

This is important for human to human interaction. Oxytocin is also released during physical contact between two people, and we know it is released in large amounts particularly during sexual intercourse.

As a therapy, oxytocin has been very helpful particularly for social anxiety. There are a couple of other effects that are interesting with oxytocin. Oxytocin seems to help with facial cue recognition. That enables us to tell the difference between a happy face, sad face, inquisitive face, etc. It also helps with voice cue recognition as well.

They did a study with adults on the autism spectrum and who had Asperger’s as well and they gave them an IV infusion of oxytocin and then measured their response over a two week period of time. What they found was that the individuals that received the oxytocin did much better at looking at pictures of different facial expressions and picking out the differences as well as listening to recordings of different voice emotional cues: an angry voice, a happy voice, etc.

Oxytocin is a useful remedy to consider particularly if the child, teenager or adult that you know has social anxiety issues or lacks the recognition of facial and/or voice cues.

Oxytocin comes as a nasal spray and does need to be prepared by a compounding pharmacy.

Usually you dose oxytocin once a day, maybe twice a day or even as needed situationally. You can give oxytocin before going into a situation where your child has a problem with social anxiety.

Dr Woeller uses the Meridian Valley Lab 24-hr urinary oxytocin test which, according to them “is the best method to capture the pulsatile peaks and valleys of oxytocin production.” You can order the test (and interpretation) via his testing site Lab Tests Plus

There are a number of studies that support the use of oxytocin for improving eye-contact, facial recognition and social anxiety:

Oxytocin increases eye contact during a real-time, naturalistic social interaction in males with and without autism

Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder

Oxytocin improves behavioural and neural deficits in inferring others’ social emotions in autism

Intranasal oxytocin in the treatment of autism spectrum disorders: a review of literature and early safety and efficacy data in youth

Effects of oxytocin on attention to emotional faces in healthy volunteers and highly socially anxious males

Here is a snippet from my book The Antianxiety Food Solution on the estimates of the prevalence of pyroluria (be aware that can vary depending on the type of clients/patients a practitioner works with):

Joan Mathews-Larson, considered an expert on the subject, reports the prevalence as follows: 11 percent of the healthy population, 40 percent of adults with psychiatric disorders, 25 percent of children with psychiatric disorders, 30 percent of people with schizophrenia, and 40 percent of alcoholics.

Abram Hoffer worked primarily with schizophrenic patients, but he found pyroluria was also present in 25 percent of his nonschizophrenic patients, including adults with anxiety, depression, and alcoholism, and children with learning disorders and behavioral disorders.

According to McGinnis, pyroluria is also present in about 46 percent of people with autism spectrum disorders and 71 percent of those with Down syndrome.

I work primarily with adult women who are anxious, depressed, or both and have found that at least 80 percent of my clients with moderate to severe anxiety have a large number of pyroluria symptoms.

Based on this and the research we’re seeing on autism, social anxiety and oxytocin, I would expect that if you have pyroluria you may also have low levels of oxytocin and may need to address this, especially if you not getting complete resolution with the zinc, vitamin B6 and evening primrose oil.

Oxytocin and social anxiety, pyroluria and depression?

March 27, 2015 By Trudy Scott 66 Comments

A 2014 paper published in the Journal of Psychiatric Research looked at how variations in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress. Here are some excerpts from this paper:

Oxytocin is a neuropeptide that is involved in the regulation of mood, anxiety and social biology.

Genetic variation in the oxytocin receptor gene (OXTR) has been implicated in anxiety, depression and related stress phenotypes.

In this study, we examined genotypes in 653 individuals and tested whether SNP variation in OXTR correlates with severity of features of self-reported experience on the Depression Anxiety and Stress Scale (DASS), and whether this correlation is enhanced when early life trauma is taken into account.

The study found a significant effect of several oxytocin receptor genes (OXTR genotypes) on anxiety, stress and depression scores. They concluded that:

These results support the hypothesis that the oxytocin system plays a role in the pathophysiology of mood and anxiety disorders.

In this 2015 paper published in Neuropsychopharmacology, they looked at “Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder” and found that oxytocin lessened anxiety by dampening amygdala reactivity to threat in individuals with generalized social anxiety disorder.

Results indicated that in individuals with generalized social anxiety disorder:

Oxytocin enhanced functional connectivity between the amygdala and the bilateral insula and middle cingulate/dorsal anterior cingulate gyrus during the processing of fearful faces

These findings suggest that [oxytocin] may have broad pro-social implications such as enhancing the integration and modulation of social responses.

We know that low serotonin can cause anxiety, worry and depression and research shows there are interactions between oxytocin and serotonin levels. So if you don’t respond to serotonin support (tryptophan or 5-HTP or light therapy), maybe boosting oxytocin is a possible solution? Or maybe supporting serotonin will boost oxytocin?

What is also really interesting to me is that zinc is needed for binding oxytocin to its receptor so I wonder about the oxytocin connection to pyroluria, a social anxiety condition where higher amounts of zinc and vitamin B6 are needed. I wonder if adding oxytocin to the mix or boosting it would help even more? Or if optimizing zinc use and absorption would help promote oxytocin?

Have you had your oxytocin levels tested? Have you used oxytocin with good results and did it help your social anxiety/pyroluria and/or depression? Have you done anything else to boost your oxytocin levels?