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social anxiety

Sjogren’s syndrome: tryptophan and GABA for anxiety, and moisturizing for dry skin and inflammation?

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sjogren's syndrome

A few weeks ago I blogged about a new pilot study about the use of a skin moisturizer twice a day reduced inflammation in older adults. I use the inflammation research to question if this may be applicable and helpful for you if you suffer from anxiety, extrapolating that it may well be given the added benefits of touch and an oxytocin boost.

I received a number of great questions about how to apply this information and have decided to share a question from someone with both Sjogren’s syndrome and anxiety, in order to illustrate how I’d work with someone like this.

Here is the question I received:

I would like to know how much of one’s body needs to be moisturized, and if it is also necessary to be done twice per day? Such a simple but effective way to help with anxiety. Will be slathering a lot more in the future! I have Sjogren’s so everything is dry – skin, mouth, eyes, hair. I have been trying to keep my face much “moister” and I am sure my wrinkles have lessened. I find rice bran oil is also quite good.

I’m going to address her moisturizing question below and share more about anxiety in Sjogren’s syndrome and some nutritional solutions, but first let me explain what Sjogren’s syndrome is.

An overview of Sjogren’s syndrome

Let me explain what Sjogren’s (SHOW-grins) is in case you’re not familiar with this condition. It’s an autoimmune condition and is described as follows on the Mayo Clinic site:

often accompanies other immune system disorders, such as rheumatoid arthritis and lupus. In Sjogren’s syndrome, the mucous membranes and moisture-secreting glands of your eyes and mouth are usually affected first — resulting in decreased tears and saliva.

Although you can develop Sjogren’s syndrome at any age, most people are older than 40 at the time of diagnosis. The condition is much more common in women.

The site goes on to say that other than dry eyes and mouth, some people experience joint pain and stiffness, swollen salivary glands, skin rashes or dry skin, vaginal dryness, persistent dry cough and prolonged fatigue. It’s worth a read to learn more about complications like more dental cavities, yeast infections, vision issues, problems in the lungs, kidneys or liver, the risk of lymphoma and peripheral neuropathy.

My feedback about moisturizing

In the study, moisturizing was done twice a day. I’m not sure how much of the body needs to be moisturized but if everything is dry, I’d want to moisturize as much as possible.

Given that chronic inflammation is a major factor in Sjogren’s and other autoimmune conditions like systemic lupus erythematosus, it’s feasible to expect similar benefits in terms of reduced inflammation. Hopefully we’ll see research on autoimmune conditions in the future.

When it comes to anxiety, I do want to make it clear that I was and still am extrapolating from the research on inflammation and measuring reduced anxiety was not part of the study. Moisturizing may or may not help with anxiety and I certainly wouldn’t only use this intervention.

Anxiety in Sjogren’s – low serotonin and GABA?

You may not be aware that anxiety/depression is very common in Sjogren’s. In one study they

found 33.8% patients with anxiety, and 36.9% had depression, which were significantly higher than controls.

I use a comprehensive nutritional and lifestyle approach to help my clients ease their anxiety and as I mention above, I would not only rely on moisturizing.

I would use the serotonin questionnaire to determine if low serotonin is contributing to the anxiety (the worry-in-the head and rumination type of anxiety) and do a trial of tryptophan or 5-HTP.

Interestingly, a number of studies suggest the involvement of the serotonin system in the development of Sjogren’s, with one study reporting

Significantly lower platelet levels of serotonin in Sjogren’s patients as compared to healthy controls.

They didn’t find a correlation between the levels of serotonin and how severe the Sjogren’s symptoms were, which falls in line with what we know about biochemical individuality and why doing a trial of tryptophan or 5-HTP (to find your ideal dose) is the best approach for serotonin support.

I would use also the GABA questionnaire to determine if low GABA (physical tension type of anxiety) is a factor, and do a trial of GABA.

If you recall, in the Mayo Clinic description above, stiffness is a common symptom of Sjogren’s and GABA eases stiffness.

I haven’t found any research on GABA in Sjogren’s, but one case study reports that a patient experiencing athetoid movements (a movement dysfunction, characterized by involuntary writhing movements), reported symptom improvement with hydroxychloroquine, pilocarpine, gabapentin, and clonazepam. The latter two medications work on the GABA system.

You can find the tryptophan and GABA products I use with my clients here.

Poor sociability in Sjogrens – could this be related to pyroluria?

A study published earlier this year is reportedly the first study to conclude that patients with Sjogren’s score “high on neuroticism and anxiety and low on sociability.”

If social anxiety is a concern, I’d have her do the pyroluria questionnaire and address this if needed.

If you recall, in the Mayo Clinic description above, joint pain and dental cavities are common symptoms. These are also very common with pyroluria, so using a nutritional approach helps ease the social anxiety, and improves joint issues and mouth health.

The other factor that makes me suspect pyroluria may be common in Sjogren’s is that it’s considered a systemic connective tissue disorder, together with systemic lupus erythematosus and rheumatoid arthritis. You can read more about pyroluria and connective tissue disorders on the pyroluria prevalence blog and the Ehlers Danlos/joint hypermobility blog.

Poor mouth health is also common with histapenia/low histamine so I’d want to look into this too.

You can find the pyroluria supplements I use with my clients here.

Sjogren’s and the Autoimmune-Paleo diet

Since Sjogren’s is an autoimmune condition, following an Autoimmune-Paleo (AIP) diet is key too. Here are some books that are well-worth making part of your library, even though they are not specific to Sjogren’s syndrome they offer support for autoimmune conditions (and many individuals often have more than one autoimmune disease)

Here is one more resource for you: The Autoimmune Masterclass which airs online this weekend It’s a similar format to online 7-day summits but runs for 2 days instead and is no-cost to attend during these two days.

I haven’t dived into the research on all the other autoimmune conditions and the above connections (low serotonin, low GABA and pyroluria) but it’s highly likely similar connections exist. So, if you have any autoimmune condition and anxiety this could all apply for you too.

If you have been diagnosed with Sjogren’s syndrome please share if GABA and tryptophan have helped ease your anxiety, and if the pyroluria protocol has helped you with social anxiety?

And let us know if moisturizing is helping your dry skin and possibly reducing inflammation and anxiety too?

The role of functional neurology, the cerebellum and brain balance exercises for anxiety, depression, social communication, ADHD and obsessions

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Here are some snippets from a fascinating interview sharing cutting edge information on functional neurology and the cerebellum on the Autism, ADHD and Sensory Processing Disorder Summit

Dr. Peter Scire, DC covers: How to Induce Neuroplastic Change in Your Teenager and Make it Fun. He shares how brain hemisphere imbalances and misfiring can be assessed and corrected with very specific exercises to induce neuroplastic change (in both children and even adults). 

I want to bring attention to, really what Schmahmann calls the cerebellum cognitive affective syndrome, so CCAS. It’s been in the literature now for 20 years. And now he’s developed a way to actually do a checklist and to look at these different aspects. But ultimately what he’s saying is that the cerebellum networks have huge relationships to your cognition of executive functions: like working memory, linguistics (your ability to generate language and to actually comprehend language), your affect, so your mood and your emotional stability. Being able to not only generate emotions, but also be able to receive emotions.

These are things that we thought for a long time were at the higher center of the brain, more of the frontal lobe specifically….. But again, the more that we’re looking at the neuro anatomy through neuroimaging, we’re able to really say, guess what? There are certain pockets of the cerebellum that specifically drive these networks.

He talks about the 3 major parts of the cerebellum, 10 subparts and how 5 of these subparts actually deal with non-motor aspects (i.e. mood and emotions, ADHD etc.). It’s this latter aspect – the non-moto aspects – that is not recognized in mainstream neurology and that forms the some of the central aspects of functional neurology: 

What we know about the cerebellum is that we have three major parts to it, and then there’s actually like 10 sub parts to it. And these 10 sub parts to it have different connections and when you look at the 10 sub parts, the first 5 have to do with more sensory motor aspects of the cerebellum. And then really the other 10 or so, give or take, are really dealing with non-motor aspects.

We have areas from the cortex that speak back to the cerebellum. We call them cerebral cerebellum loops. And then we have cerebellum back to the cerebrum. It kind of makes this bio directional system. Now it’s a little bit more complicated than that. There are other parts of the motor center, the basal ganglia and these other parts in the limbic system and stuff like that. But from a simple standpoint, for most of our attendees that understand brain gut access, just think about it in that sense. Cerebellum … brain, cerebellum, cerebellum back to the brain, okay?

And so we can have dysfunction in those systems. But again, most of the clinical model has always been looking at brain to cerebellum, not cerebellum back to the brain. And I think in my experience over the last 15 plus years, most of the work in functional neurology has actually been centered around, even chiropractic per se has been centered around cerebellum to brain, but we now are even getting more specific with our therapeutic entities.

Dr. Scire discusses the under-recognized relationships between the cerebellum networks and ADHD, social communication, mood, and emotional aspects, relationships, obsessions, compulsions, anxiety and depression: 

Again, when you look at the different phases of his work, you want to look at executive function – the whole ADHD population. You look at the linguistic processing. Obviously, we know language and social communication for autism spectrum disorders. Looking at spatial cognition so visual spatial information, visual memory aspects. Then you can begin to look at not only mood, and emotional aspects, but also relationships, obsessions, compulsions, anxiety and depression.

All this continuum of symptomatology can be traced back to the cerebellum. I agree with Doctor Melillo on this hemisphere communication model. But at the same time, in my opinion, I think that we can take it one step further and even get into the specifics of starting with these networks in the cerebellum. It starts out with this very specific examination to say okay, I want to look at motor functions of the cerebellum and I also want to look at non-motor functions of the cerebellum. And then my therapeutic entity is going to be based on that.

You can watch the video snippet of the above here

Dr. Scire shares the research published by Dr. Schmahmann. In this paper, The neuropsychiatry of the cerebellum – insights from the clinic they discuss the behaviors that they witnessed and that were described by patients and families:

distractibility and hyperactivity, impulsiveness, disinhibition, anxiety, ritualistic and stereotypical behaviors, illogical thought and lack of empathy, as well as aggression and irritability. Ruminative and obsessive behaviors, dysphoria and depression, tactile defensiveness and sensory overload, apathy, childlike behavior, and inability to appreciate social boundaries and assign ulterior motives were also evident.

He also recommends Dr. Robert Melillo’s book: Disconnected Kids: The Groundbreaking Brain Balance Program for Children with Autism, ADHD, Dyslexia, and Other Neurological Disorders (my Amazon link). I’ve skimmed it and will be doing a review –the functional neurology information is brilliant. I’d love to see the dietary information expanded upon.

In this interview you will learn…

  • What the latest research says about the role of the cerebellum in cognition and motor planning [and the role it also plays in anxiety, depression and ADHD]
  • What to look for when assessing cerebellar function.
  • How the cerebellum impacts executive function.
  • How to rehabilitate the brain and the importance of movement.
  • How to treat young adults with neurological disorders.
  • How what may seem to be “simple” exercises you can do at home with your child can have a major impact on their cognitive function.

I also had the pleasure of speaking on a panel with Dr. Scire and Dr. Leila Masson last week – you can watch this here. We discuss some of the above and a great deal more

Facebook Live Panel with Tara Hunkin, Dr Leila Masson, Dr. Peter Scire DC, and Trudy Scott.

I learned so much from his interview and our panel discussion and will be delving into this aspect of functional neurology in order to add this element for clients who need this support beyond nutrition and functional medicine.

If you’re new to my work and the targeted individual amino acids be sure to catch my interview: Self-care strategies for parents that are stressed out, anxious and depressed – without using medications.

Using the targeted individual amino acids (such as tryptophan, GABA and DPA) provides quick relief from anxiety and overwhelm, giving my clients hope from day one.  And then we start to dig deeper for other root causes which can often take some time.

In this interview my focus was for stress and overwhelm support for parents but the use of amino acids is very applicable to children (and was the topic I covered in my interview in the first season).

You can watch a video snippet of me sharing more about the amino acids here

As I learn more I expect to find that the amino acids used in conjunction with functional neurology is going to provide more comprehensive results for many individuals who also have cerebellum dysfunctions.

This event brings together 30+ of the leading doctors, nutritionists, and researchers working to help parents by sharing the latest information and strategies for achieving recovery for children with Autism, ADHD and Sensory Processing Disorder.

If you have (or a loved one has) anxiety, depression, OCD,  social anxiety, anger issues and other behavioral symptoms this event is one I highly recommend. Alzheimer’s disease, dementia and Parkinson’s disease are also covered in Dr. Scire’s interview.  This information has a wider application than autism, Asperger’s syndrome, ADHD and SPD and you will learn a great deal.

If you’ve benefited from functional neurology and these brain balancing exercises please do share in the comments. Feel free to post questions too.

30 Experts Share Their Best Advice for Brain Health by Jordan Fallis

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Jordan Fallis of Optimal Living Dynamics reached out to some of his favorite cutting-edge health practitioners and researchers and asked them one question:

What is the one piece of advice you would offer to people who want to improve and optimize their brain health?

I was thrilled to be one of the people he reached out to. This is my response:

This a tough question and I can think of many things such as eating sardines or other oily fish for the omega-3 benefits; eating pumpkin seeds as a great source of zinc and tryptophan (both great for anxiety and depression); dumping the bread and cookies due to the inflammatory effects of gluten on the brain and body; and eating grass-fed red meat as a great source of zinc, omega-3s and iron, all of which are needed for brain health. 

But if I had to pick only one piece of advice, I would say to optimize gut health because of the very strong gut-brain connection. This means healing a leaky gut with an amino acid like glutamine; improving the microbiome by eating fermented foods like sauerkraut; improving protein digestion with enzymes; cooking and eating quality food at home; chewing our food slowly, and addressing issues like candida, parasites, small intestinal bacterial overgrowth and dysbiosis.

In addition to the above, I always trial the use of targeted individual amino acids such as calming GABA, mood-boosting tryptophan and DPA, and addressing nutritional deficiencies with nutrients like zinc, vitamin B6, iron, magnesium and so on. You may need to also address Lyme disease, mold, heavy metals and many of the other possible biochemical causes of anxiety and depression.

Here are some snippets from a few of my favorite quotes:

  • Kelly Brogan: the brain “does not understand modern chemicals, processed foods, and industrial pollutants. It also doesn’t understand chronic stress, poor sleep, minimal movement, and indoor living”
  • Hyla Cass: “don’t follow a low-fat diet! Make sure to get sufficient fats and protein. Avoid trans fats, but eat healthy fats like omega 3’s found in fatty fish, and medium chain triglycerides from coconut oil”
  • Sayer Ji: “Turmeric is one of the most remarkable neuroprotective and neurorestorative agents yet identified”
  • Max Lugavere: “…there’s simply nothing like exercise for the brain.”
  • Gwen Olson: “Do your own due diligence before taking any pharmaceuticals. Put the name of the drug into a search engine followed by the words ‘controversy’ and ‘side effects’”
  • James Greenblatt: “As vitamins and minerals serve as co-factors in almost every enzymatic reaction in the brain, it is important to assess for adequate nutrient levels regularly to ensure that you are optimizing brain health”

You can read all the inspiring and valuable responses on Jordan’s blog: 30 Experts Share Their Best Advice for Brain Health. You’ll see some common themes: stress, the gut, exercise, real food, sleep and nutrients.

When I asked Jordan how he knew of me and my work he shared this:

I found you through Sean Croxton’s Depression Sessions. When that first came out, I was in the middle of my journey, trying to restore my own mental health. It was great timing. So I immediately purchased it and watched all the videos for more solutions.

I already knew about pyroluria, as I had read Dr. William Walsh’s book Nutrient Power at that time. But it was great to see you talk about it and bring it to light! And I believe I was taking just regular B6 before your talk. So then I switched to P-5-P. I continue to take P-5-P and zinc picolinate regularly.

I’m so thankful I’m feeling better and have my life back, so I’m going to work really hard to share everything that helped me. I just feel like I need to do that 🙂

I really appreciate that Jordan wants to share everything that has helped him and this article is a perfect way to do this.

Here are some additional resources for you on pyroluria, the social anxiety condition he mentions above:

I hope you enjoy these resources from me, Jordan and all the experts he reached out to!

I’d love to hear what you have found to be the best brain advice you have received and implemented?  

 

I suffer from severe anxiety, have social anxiety and am afraid of everything

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For the first time I have come across your blogs about amino acids and anxiety. I’ve suffered from severe anxiety since 2011, and have tried the SSRIs and hate them. I refused to take them, as they caused me to gain so much weight and [have] withdrawals. I’ve also read how bad they are for you.

In order to work, I am relying heavily on 0.5mg of Clonazepam up to 3-4 times a day. It makes me so drowsy in the mornings. I try for the most part to make sure to get 7-8 hours of sleep because I can tell how when not having enough rest can trigger my anxiety. But I’m in desperate need of a solution. Not sure if the clonazepam is something I can continue to take long term, as I also know it’s bad for you.

I suffer from social anxiety (on a level 1-10, I would be 20!) and also some agoraphobia symptoms [an abnormal fear of being in crowds, public places, or open areas, sometimes accompanied by anxiety attacks.]. I am not able to go to stores alone, and I am afraid of everything.

I suffer at work the most, because I’m constantly busy and stressed and dealing with customers all day. Please help

The above question was recently posted on my blog and I’m sharing my response to her in case you are new to using the amino acids for neurotransmitter imbalances and may be able to relate to any of the above. This is my response to her:

Welcome to the community! I use the amino acids with clients and do a trial to find out if they are needed and how much to use. This blog post Anxiety and the amino acids: an overview has links to the amino acid questionnaire, the precautions and how to do a trial. When someone has fear and phobias I immediately think we need to be looking at low serotonin and a trial of tryptophan. It’s not uncommon to also see low GABA and blood sugar imbalances being an issue too.

Once you address low GABA, low serotonin and low blood sugar I would expect the work stresses to feel less overwhelming. In an ideal world it would be wonderful to be able to remove this stress so I encourage you to consider this too.

For social anxiety I start with the pyroluria questionnaire. The great aspect of this is the nutrients for pyroluria – zinc, vitamin B6 and evening primrose oil – help the social anxiety and help to make the neurotransmitters. They also happen to help with PMS and other hormonal imbalances too.

Keep in mind it’s a comprehensive nutritional approach that I use with clients so we are also looking at diet, blood sugar control, the gut, adrenals and thyroid health, quitting sugar and caffeine and so much more. My book The Antianxiety Food Solution (on Amazon here) covers everything in detail, including the amino acids and pyroluria.

I’m sure you’re aware that Clonazepam (or Klonopin) is a benzodiazepine and should be prescribed a maximum of 2 weeks and even then they can be problematic. It may likely be contributing to your anxiety. Here is one blog post to get you started with some information about benzodiazepines: World Benzodiazepine Awareness Day – say NO to Benzodiazepines for anxiety! It covers tolerance issues and resources for tapering. I encourage you to search the blog to find plenty of additional information about the benzodiazepines.

Be very careful with the morning drowsiness as there is an increased risk of being involved in a road accident as driver when on a benzodiazepine prescription.

I speak on selected online summits that I know will be of value to my community so do keep reading the newsletter. The summits are a great way to start learning about my work and other nutritional and functional medicine approaches for anxiety and other chronic health conditions so be sure to sign up and tune in. There is also a wealth of information on this blog.

Can Social Anxiety Be Reversed with Nutrition?

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underground-wellness-radio

Sean Croxton host of Underground Wellness Radio shares how:

  • he was once prescribed Paxil for social anxiety (and depression)
  • he doesn’t like big crowds
  • he can speak on stage in front of 100s of people with no problem
  • as soon as people come to talk to him afterwards he wants to go!

Can you relate to any of this?

He thinks he has pyroluria, a social anxiety condition where you have a higher need for some key nutrients: zinc, vitamin B6 and evening primrose oil.

We are often surprised when we hear that someone who appears to be outgoing and extroverted (like Sean) actually has social anxiety.

It’s more common than you think and is made worse under stressful situations: life stresses, gluten sensitivities etc.

I share how my social anxiety got really bad in my late thirties (when my PMS was so bad) and how

  • many of us with pyroluria push through and deal with it
  • we just want to stay home
  • we don’t really want to see people

Not everyone needs omega-3 supplements!

We discuss omega-3s and omega-6s and how pyrolurics often don’t need to supplement with omega-3s like fish oils but can extract the omega-3s from the foods they eat: grass-fed red meat, wild fish like salmon, leafy greens and walnuts.

Pyrolurics often do need to supplement with the GLA form of omega-6 that we find in evening primrose oil as GLA is often low, plus the GLA enhances zinc absorption.

(by the way: I said alpha linolenic acid (ALA) but should have said gamma linolenic acid (GLA)

A good copper-free multi is part of the protocol because low zinc often means high copper and this can make you more anxious.

Looking at other sources of copper is a helpful for many pyrolurics: eating too many nuts, baking with nut flours, the copper IUD.

You don’t want to miss this part…Sean asks if you can cure introversion with this pyroluria protocol. If you are an introvert and force yourself in social settings, feel very uncomfortable and anxious being around big groups of people then you’re going to have to watch the end of the video for my answer!

You can watch the whole snippet here  

This is part of my interview on the Depression Sessions, a FREE online event hosted by my friend Sean. I’ll also be sharing information about the amazing amino acids – inexpensive, over-the-counter supplements that can lift your mood and end anxiety in minutes!

Sean traveled the country to interview the best of the best experts — medical doctors, naturopaths, nutritionists, and bestselling authors — on what really causes depression and anxiety and what to do about it. 

Some of us (like me) flew to San Diego to be interviewed in his home. It was such a thrill to be interviewed by the legendary Sean Croxton and is an honor to be part of this group of experts!

Here are just a few of the amazing experts you’ll hear from:

  • Suzy Cohen, also known as America’s Pharmacist, uncovers specific prescription drugs that rob your body and brain of mood-friendly nutrients.
  • Datis Kharrazian will show you what insomnia, anxiety, and the symptoms that tag along with depression can tell you about what’s causing it.
  • Hyla Cass, a medical doctor and integrative psychiatrist (who has been featured on two prior Anxiety Summits), shares her best tips for transitioning OFF of psychiatric meds while avoiding or minimizing common withdrawal symptoms.
  • Ben Lynch (another Anxiety Summit favorite) reveals the incredibly common genetic mutation known to drive depression (and anxiety) … and the critical nutrients that make such a big difference.

This is not your ordinary online health summit. You can expect high-quality interviews, HD production and picture quality, and a life-changing experience!

Click HERE to sign up and to watch the trailer (I hear it’s gone viral on Facebook!) and catch me sharing some scary facts on medications and very young kids, and some excellent gems from other speakers on the Depression Sessions.

Of course you’ll also get access to my whole interview, when it airs in June, plus all the other great interviews.   Just be sure to sign up here to get access to all of them:  https://at105.isrefer.com/go/depreg/trudyscott/

 

Pyroluria/social anxiety protocol: why aren’t I getting results? (trouble-shooting checklist)

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How do you trouble-shoot when you score high on the Pyroluria Questionnaire from The Antianxiety Food Solution  or even have a positive pyroluria urine test but you don’t seem to be getting the results you expect?

You still have social anxiety, that inner tension that you push through and deal with, and likely still feel uncomfortable when in large groups. You force yourself to put on the confident brave face. You may wish you could be more like your extrovert friends and actual enjoy socializing and speaking in public/on stage – without the fear and anxiety. You may still not be a big breakfast eater and have morning nausea. You may not yet be having pleasant dreams that you always remember.

(If pyroluria is new to you here is the Pyroluria Questionnaire from The Antianxiety Food Solution and here is a nice summary – Pyroluria, social anxiety, introversion: a summary )

This checklist is a starting point to try and figure out what may be the issue. These are the questions I’d work through with someone who is working with me one-on-one.

I discussed 21 of these in my interview on season 3 of the Anxiety Summit: Pyroluria, Amino Acids and Anxiety: Troubleshooting when you are not getting results

As you heard during the interview, I added MTHFR and I’ve even added a few more since then. I expect this list to grow.

  1. What form of zinc are you taking and is it free from copper? My favorite is Optizinc (zinc monomethionine)
  2. Have you made sure that there is no copper in your multivitamin or other supplements?
  3. Have you been taking evening primrose oil and if yes, how much?
  4. Did you test your fatty acid levels? What are the results? Did it show a need for GLA (I like evening primrose oil rather than borage oil)
  5. What is your alkaline phosphatase (blood test) – less than 70 may indicate a need for zinc
  6. Have you done the zinc tally/challenge with zinc sulfate and does it taste like water or does it taste really bad? If you zinc levels are good it should taste really bad
  7. Did you test copper and ceruloplasmin, and if yes, what were the results?
  8. Did you do the pyroluria urine test? What are the results?
  9. What’s your score on the pyroluria questionnaire ? And which symptoms do you have?
  10. What is your score on the introversion questionnaire?
  11. What were your dreams like before starting the protocol and now? How high did you go on the vitamin B6?
  12. On a scale of 1-10, what was your social anxiety before and now (10 is worst)
  13. What is your stomach acid like? And have you trialed Hcl supplements? Tested total protein (in blood)
  14. Do you eat grass-fed red meat (a good source of zinc, iron and omega-3s?
  15. Do you eat sugar? Refined sugar and processed foods? Or even “healthy” sweeteners such as honey in large quantities? (sugar depletes zinc)
  16. Do you eat large quantities of nuts or bake with nut flours? (the copper in the nuts may be affecting your zinc)
  17. Do you have a copper IUD, copper pipes, copper pots?
  18. Have you done a hair analysis and found high copper or high hidden copper?
  19. How much and how often do you exercise? What about bikram/hot yoga? Sweating depletes us of zinc
  20. Have you used any of the amino acids? And seen good results?
  21. Do you eat gluten and have a gluten sensitivity? If yes, have you healed your gut? If not, you may have malabsorption
  22. Are you completely grain-free? This may be impacting your vitamin B6 levels)
  23. Do you have amalgams/silver fillings? Did you have them removed and did a mercury detox? Were you tested for heavy metals? Zinc absorption can be blocked by heavy metals (we talked about this in season 2)
  24. Do you have the MTHFR polymorphism? It’s common with pyroluria and this may mean you need higher amounts of the supplements
  25. Do you have high histamine/hisadelia or low histamine/histapenia? Pyrolurics often have one or the other
  26. Are you taking benzodiazapines or have recently quit benzodiazapines? Your unresolved anxiety may be due to this fact (we talked about this in season 1)
  27. Do you have parasites, candida, dysbiosis, SIBO or other digestive issues? These can be considered stresses and pyroluria symptoms are worse under stress
  28. Do you have Lyme disease or another infection? These can be considered stresses and pyroluria symptoms are worse under stress
  29. Do you have food sensitivities?  This may contribute to malabsorption.  This can also be considered a stress and pyroluria symptoms are worse under stress
  30. Do you have problems with histamine-containing foods? This can be considered a stress and pyroluria symptoms are worse under stress.  Also, vitamin B6 is a co-factor needed for the DAO enzyme, which is responsible for the degradation of histamine.
  31. Do you have issues with oxalates? This can be considered a stress and pyroluria symptoms are worse under stress. Oxalates can also bind to minerals and lower the levels
  32. Have you been/are you exposed to mold and other toxins? These can be considered stresses and pyroluria symptoms are worse under stress
  33. Do you have low oxytocin levels?  Do you have a genetic variation in the oxytocin receptor gene (OXTR). Oxytocin has been implicated in anxiety, depression and related stress phenotypes
  34. Is your life super-stressful? Stress makes pyroluria worse
  35. Do you have adrenal issues? We need good adrenal function for optimal digestion, being able to handle stress and being able to fight off infections/avoid getting parasites and dysbiosis
  36. Do you have hormonal issues – PMS, perimenopausal or menopausal symptoms?  The pyroluria protocol helps and this could be a clue that something is off

This list is NOT in my book The Antianxiety Food Solution but the pyroluria questionnaire, protocol and testing information is (my book has a whole chapter on pyroluria).

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here: www.theAnxietySummit.com

Missed this interview or can’t listen live? Or want this and the other great interviews for your learning library? Purchase the MP3s or MP3s + transcripts and listen when it suits you.

You can find your purchasing options here: Anxiety Summit Season 1, Anxiety Summit Season 2, and Anxiety Summit Season 3.

Please share your results and ask questions in the comments.