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Anxiety in autism, ADHD and sensory processing disorders

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I had the pleasure of being interviewed by Tara Hunkin on the upcoming Autism, ADHD and Sensory Processing Disorder Summit and share my expertise on anxiety since we so often see anxiety in this population. My topic is: Anxiety’s Role in ASD, ADHD and SPD and how nutrient therapy can help.

I start out sharing some of the research on the incidence and connections.

This 2009 paper Sensory Overresponsivity and Anxiety in Children With ADHD in the American Journal of Occupational Therapy, reports that:

Approximately 25% of children with attention deficit hyperactivity disorder (ADHD) have a comorbid anxiety disorder.

The purpose of this particular study was to determine whether sensory overresponsivity (SOR) or sensory processing disorders are related to increased anxiety in children with ADHD. There were twenty-four children between the age of 6 to 10 with ADHD and 24 children without ADHD.

The study concluded that:

Children in the ADHD + SOR [sensory over responsivity] group were significantly more anxious than both the ADHD-only and non-ADHD (control) groups.

Occupational therapists treating children with ADHD and SOR should be aware that these children may also have anxiety and discuss options with families for prevention or treatment.

I would add that anyone working with these children should be aware of the connections: doctors, nutritionists, psychologists and anyone else on the health team.

We also discuss this 2012 paper, also from the American Journal of Occupational Therapy – Sensory Overresponsivity and Anxiety in Typically Developing Children and Children With Autism and Attention Deficit Hyperactivity Disorder: Cause or Coexistence?

Reviews of the coexistence of ASD [autism spectrum disorder] and anxiety disorders have concluded that among children and youth with ASD, anxiety disorders are highly prevalent, clinically significant, and varied as to specific type of anxiety disorder

Approximately 25% of children with attention deficit hyperactivity disorder (ADHD) also have anxiety disorder, a rate that is elevated when ADHD is seen in conjunction with conduct or oppositional defiant disorders

The paper mentions these 3 factors as models worthy of further study in order to understand the relationship between anxiety, sensory overresponsivity, autism and ADHD:

(1) anxiety caused by, or a symptom of, SOR (primary anxiety model);
(2) SOR caused by, or a symptom of, anxiety (primary SOR model); and
(3) the presence of both anxiety and SOR, linked by way of another factor

Based on what I know about anxiety I feel it could be a combination of all of the above.

My interview also covers the following around how to address the anxiety in these children and their moms (who also often have anxiety):

  • Low serotonin anxiety, symptoms, using tryptophan and 5-HTP and precautions with using them with an SSRI
  • A young girl with RAD (reactive attachment disorder) with rage/anger, anxiety, insomnia, and sugar cravings and the successful use of chewable tryptophan, addressing low iron and a gluten-free diet
  • A young boy with OCD and the successful use of both tryptophan and inositol
  • Low GABA anxiety, the use of GABA and not phenibut, and cautions about using too much
  • A young girl with ADHD and irritability and the successful use of GABA
  • Pyroluria incidence and symptoms and how it ties back to neurotransmitter imbalances

Sensory processing disorders, ADHD and autism are not my expertise and I don’t work much with children so I’m really pleased to be bringing you this information via the other amazing speakers AND listening and learning myself!

Here are some speakers and topics I’m particularly interested in

  • Brandon Brock, RN, DC: Understanding PANS and PANDAS role in ASD, ADHD and SPD.
  • Elizabeth Mumper, MD: Mitochondrial Dysfunction: What it is and how to address the underlying causes.
  • Richard Frye, MD, Ph.D.: Cerebral Folate Deficiency: and how it impairs neurological health.
  • Nancy O’Hara, MD: What you need to know about cell danger response in ASD & other neurodevelopmental disorders.
  • John Tjenos, NTP: The importance of the vagus nerve and how to build vagal tone with essential oils.

We have so much to learn from practitioners and researchers working in this area. And children affected by these conditions do recover!

The Autism, ADHD and Sensory Processing Disorder Summit, hosted by Tara Hunkin, NTP, runs from June 19-28, 2017.

It will be 10 days of eye opening information into the root causes of your child’s neurological dysfunction. Imagine learning about what may have caused their symptoms and how to address them with nutrition and biomedical approaches and leverage the power of positive neuroplasticity to improve function, health and their lives.

Do also keep in mind that these topics may have relevance for you even if you don’t have a child with a sensory processing disorder, ADHD and/or autism. These children are the canaries in the coal mine and many of my clients with anxiety can benefit from the biomedical support that many of these speakers are addressing. Simply replace sensory processing disorder, ADHD and/or autism with anxiety and listen and learn.

You can register for The Autism, ADHD and Sensory Processing Disorder Summit here

Feel free to ask questions or provide feedback and your experiences in the comment section below.

Autism, anxiety and the gut: Microbiota transfer therapy or fecal microbiota transplant

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We know that one of your greatest ally in health is your microbiome – the trillions of bacteria that are the control center of your health! But sometimes your microbiome can actually cause problems. One way to improve the microbiome is via microbiota transfer therapy (MTT), also called fecal microbiota transplant (FMT).  

I was recently interviewed by Dr. Raphael Kellman for the Microbiome Medicine Summit 2 (it starts May 8) and shared newly published research on this approach – Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study

Here are some of the details of this very promising research:

  • It was a small study on children 6 to 7 years old
  • They were given antibiotics for 2 weeks
  • They were given a bowel cleanse
  • They were given an extended fecal microbiota transplant. This was a high initial dose followed by daily and lower maintenance doses for 7–8 weeks.
  • By the end of treatment and 80% reduction of gastrointestinal symptoms were seen. This included: constipation, diarrhea, indigestion, and abdominal pain.
  • These gastrointestinal symptoms improvements persisted for 8 weeks after treatment.
  • They also saw behavioral autism spectrum disorder symptoms improve significantly and remain improved 8 weeks after treatment ended. These symptoms included irritability, hyperactivity, lethargy and socialization

During the interview Dr. Kellman asked what bacterial changes were observed and I didn’t have the study on hand. I looked it up after the interview and this is what they report

Specifically, overall bacterial diversity and the abundance of Bifidobacterium, Prevotella, and Desulfovibrio among other taxa increased following MTT, and these changes persisted after treatment stopped (followed for 8 weeks).

Also

following MTT, the relative abundance of Bifidobacterium significantly increased fourfold and became comparable to its relative abundance in neurotypical children

They conclude that the MTT

shifted gut microbiota of children with ASD toward that of neurotypical children … consistent with the hypothesis that gut microbiota may be at least partially responsible for GI and ASD symptoms

Research just published last month reports similar results with digestive issues and anxiety. Germ-free mice were given the fecal microbiota from healthy control individuals or IBS patients with diarrhea, with or without anxiety. They found that the microbiota profiles in the mice matched the microbiota profiles of the human donors, affecting their digestive function and anxiety levels! I’ll share more on this study in a future blog post.

I hope you’ll join us on the Microbiome Medicine Summit 2, May 8-15, 2017 to learn more

Your host, Dr. Raphael Kellman, has seen the profound healing power of microbiome medicine and how it can address many diseases.

Learn the lessons and methodologies of microbiome medicine – it could improve your health, longevity, vitality and assist with unresolved problems!

It can enhance your brain function, improve mood, reduce anxiety and depression; and address gastrointestinal illnesses, including IBS, Crohn’s and colitis; counter newly identified GI/brain syndromes; and address autism and autoimmune diseases at the root cause!

I thoroughly enjoyed my interview with Dr. Kellman and look forward to hearing all the other great interviews. You can find details and registration here

I hope you can join us!

Zinc deficiency alters chick gut bacteria makeup and function

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chick-gut-mulfunction

A press release published by Cornell University shares research that has found that zinc deficiency alters gut bacteria makeup and function:

The researchers used broiler chickens in the study, partly due to their omnivorous appetites – which allowed the researchers to feed them purified diets – and because of their fatty acids and genetic similarities to humans.

There is a great diagram in the actual study: Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function. It explains the proposed mechanisms by which a zinc-deficient gut microbiome may perpetuate a zinc-deficient state.

zinc-chick-diagram

Figure 8. Schematic diagram depicting proposed mechanisms by which a Zn [zinc] deficient gut microbiome may worsen a Zn deficient phenotype. Zn deficiency (1), caused by insufficient dietary Zn (2), induces a decrease in gut microbial diversity (3), and an outgrowth of bacteria particularly suited to low Zn conditions, leading to dysbiosis [3A–C]. Lack of dietary Zn also leads to alterations in the functional capacity of the microflora (4), causing multiple effects including decreased expression of pathways related to mineral (i.e., Zn) absorption (4A) and carbohydrate digestion and fermentation (4B). A decrease in the latter pathway may also cause a depression in the production of SCFAs [short chain fatty acids] (5), compounds responsible for improving the bioavailability of Zn. Altogether, these microbial effects may decrease Zn absorbability (6A) and disturb GI health (6B), thereby perpetuating a Zn deficient state. Red arrows and orange–lined boxes denote observations of this study, and dashed arrows and black–lined boxes describe published findings.

The above is shared here under the Creative Commons Attribution License and can be found here: Reed, S.; Neuman, H.; Moscovich, S.; Glahn, R.P.; Koren, O.; Tako, E. Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function. Nutrients 2015, 7, 9768-9784.

Zinc status is notoriously difficult to assess so I am fascinated by the findings of this Cornell University study suggesting

a simple new way to test for zinc deficiency by analyzing a patient’s fecal sample and seeing if the profile of gut bacteria matches the makeup one would expect in a zinc-deficient individual.

The authors suggest that with additional research this zinc stool test could become a noninvasive biomarker for zinc deficiency.

Zinc deficiency is common, affecting 25 percent of the world’s population, especially in the developing world.

Zinc deficiency plays a major role in anxiety and depression. Here is a recent paper on the connection between low serum zinc, high CRP (a marker of inflammation) and pre- and post-natal anxiety and depression: Lower Serum Zinc and Higher CRP Strongly Predict Prenatal Depression and Physio-somatic Symptoms, Which All Together Predict Postnatal Depressive Symptoms.

New research, soon to be published by the Journal of Neuroscience by researchers at the University of Auckland, shows the importance of zinc in autism. The study looks at how zinc can affect brain cell communication that is altered at the cellular level.

The researchers suggest this research may have applications for psychiatric disorders such as schizophrenia (and presumably anxiety and depression too).

I feel that we have an under-recognized opportunity to have a bigger impact on mental and physical health if we take zinc deficiency more seriously.

Have you had your zinc status assessed and do you supplement accordingly?

If you’re a practitioner, do you regularly check the zinc status of all your patients/clients?

The Anxiety Summit – Addressing Anxiety in Individuals with Autism

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Julie Mathews_Anxiety4

Julie Matthews, CNC, author of Nourishing Hope for Autism, was interviewed on the Anxiety Summit by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

Addressing Anxiety in Individuals with Autism

  • How common is anxiety in autism and medications commonly prescribed
  • Autism prevalence and the exponential growth and why this is important beyond those with autism
  • Underlying biochemical factors that contribute to anxiety in autism
  • The microbiome and gut involvement
  • Sensory sensitivity, light and sound sensitivity, weighted blankets and more
  • Foods, food compounds and nutrients like GABA and zinc
  • The far-reaching benefits of a BioInidividual Nutrition approach for autism, anxiety, ADHD and many chronic diseases

This is the first paper we discussed: Treatment of comorbid anxiety and autism spectrum disorders

Clinically significant anxiety occurs frequently among individuals with autism spectrum disorders (ASDs) and is linked to increased psychosocial, familial, behavioral and academic impairment beyond the core autism symptoms when present.

Up to 80% of children with ASDs experience clinically significant anxiety, with high comorbidity rates for social phobia (30%), generalized anxiety disorder (GAD) (35%), obsessive–compulsive disorder (OCD) 37%  and separation anxiety disorder (SAD) 38% having been observed (30, 35, 37 and 38%, respectively).

Patients with ASDs and anxiety are at increased risk for social avoidance, difficulties establishing and maintaining peer relationships, sleep problems, disruptions in family functioning and at school.

SSRIs have NOT been consistently linked to improvements in core ASD symptoms (e.g., communication and social skills deficits, repetitive behaviors and stereotypies) or anxiety and repetitive behaviors in youths

High rates of behavioral activation (e.g., agitation, irritability, aggression and disinhibition) and diminished tolerability have been reported across trials, which may suggest that youths with ASDs are more vulnerable to side effects compared with their typically developing peers.

Here is the initial multisystem study Julie covered at the start – Pathway Network Analyses for Autism Reveal Multisystem Involvement:  Major Overlaps with Other Diseases and Convergence Upon MAPK and Calcium Signaling

Julie covered folate receptor autoantibodies and cerebral folate deficiency (common in autism and now found in anxiety too):

It was a concept that in the autism community was brought forward by Dr. Fry and Dr. Rosignol and Dr. Quadros looking at this particular condition.  And so there’s a condition called cerebral folate deficiency.  And it’s a neurodevelopmental disorder where the baby doesn’t get enough folate to their cerebral spinal fluid in their brain.  And so they don’t get the proper development that they need.  And the reason for that is they looked into what could be causing that and they found that children with autism have a high rate of folate receptor autoantibodies.  And so what happens is the folate receptor is basically taking folate from the bloodstream and puts it into the cerebral spinal fluid.  It gets it to the brain basically.

And these folate receptors are basically what take it across the membrane.  But in children with autism they have these autoantibodies and that blocks their ability to get the folate into the brain.  So they have neurodevelopmental issues and then during their lifetime as well they still don’t have enough folate they need on a daily basis to do the things that they need to do.  So it’s an ongoing challenge for them as well.

Here are the folate receptor autoantibody studies:

Most of the research regarding these folate receptor autoantibodies are around autism.  But now it seems like we’ve seen this new animal study that actually mentions anxiety as well – Exposure to Folate Receptor Alpha Antibodies during Gestation and Weaning Leads to Severe Behavioral Deficits in Rats: A Pilot Study 

Here is Julie’s wonderful book – Nourishing Hope for Autism: Nutrition and Diet Guide for Healing Our Children  

nourishing hope for autism

Here are the digital gifts from Julie

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here: www.theAnxietySummit.com

Missed this interview or can’t listen live? Or want this and the other great interviews for your learning library? Purchase the MP3s or MP3s + transcripts and listen when it suits you.

You can find your purchasing options here.: Anxiety Summit Season 1, Anxiety Summit Season 2, Anxiety Summit Season 3, and Anxiety Summit Season 4.

The Anxiety Summit: BioIndividual Nutrition and Special Diets

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julie matthews 1

Julie Matthews, Certified Nutrition Consultant and author of award winning book, Nourishing Hope for Autism, is interviewed by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

BioIndividual Nutrition for Anxiety: How special diets and avoiding certain foods can support individuals with anxiety

  • how the body and brain are connected
  • opiates, salicylates, amines, glutamates and oxalates
  • how special diets can help: GFCF, GAPS, low oxalate diet, FODMAPs
  • how to support biochemical pathways such as sulfation and methylation

Here are some great gems from my interview with Julie:

the brain is not this isolated island all by itself: it is connected to the body and all the biochemistry in the body affects what’s going on in the brain

different people might have similar biochemical pathways that are impaired, but they may manifest that differently – for some, with anxiety, some might have ADHD, some might have autism

gut flora is a really important factor in mood

I highly recommend Julie’s book Nourishing Hope for Autism: Nutrition and Diet Guide for Healing Our Children

And Julie shared this about her book and her work

My book is called Nourishing Hope for Autism, but a lot of people that have other conditions get my book, particularly because I call kids with autism the canaries in the coalmine. They’re the ones that are telling us that our world is too toxic, there’s too many stressors, it’s too deficient in nutrients, and we need to change our ways by adding more nutrition, more absorbable forms of supplements, getting supplements in general, eating good foods that are nutrient dense. These principles are principles that apply, in my experience, to almost all healing. So we learn a lot from the kids with autism on how it might apply to anxiety and other conditions.

We discussed the overlaps we see in autism and mood disorders: digestive issues, neurotransmitter deficiencies, gluten issues, low blood sugar, pyroluria etc.

Here is an article on Dr MacFabe’s work on gut bacteria: Spotlight on the Gut Bacteria-Brain Connection in Autism

Get your free gifts from Julie:

Using Food and Nutrition to Improve Autism and ADHD (includes info on some of the special diets even though title is about autism/ADHD)

Two hour oxalate interview and transcript (for Practitioners)

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here www.theAnxietySummit.com

UPDATE: Season 1 of The Anxiety Summit concluded on Tues 6/24/14. If you’d like to be on the notification list for the next summit just sign up here www.theAnxietySummit.com

Missed this interview and want this and the other great interviews for your learning library? Purchase the MP3s or MP3s + transcripts + interview highlights and listen when it suits you

Is Roundup toxic and a cause of anxiety, autism and celiac disease?

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Dr. Stephanie Seneff, Senior Research Scientist at MIT’s Computer Science and Artificial Intelligence Laboratory, kindly agreed to share her expertise on Roundup/glyphosate on The Anxiety Summit.

This is the title of our interview: “Aluminum and glyphosate (Roundup) collaborate to cause anxiety, depression, autism and celiac disease.”

Recently Dr. Seneff has become very concerned about the current autism epidemic and her research leads her to believe that glyphosate plays a critical role in this epidemic as well as in modern diseases like anxiety and depression

During our interview Dr. Seneff shared this:

“There are a group of us who are extremely concerned because the manufacturer of glyphosate has repeatedly claimed that it’s almost harmless to humans. So people are using it very carelessly and they are not monitoring it in their blood, in their urine, in their food or in their water. Everyone is assuming that it’s fine and so it is extremely insidious and dangerous for that reason”

We also talked about how widespread the use of Roundup has been, which is all rather disturbing considering what Dr. Seneff and other researchers are finding.

Dr. Seneff shared this:

“Wheat and sugar cane… farmers have been increasingly adopting the practice of spraying these crops right before the harvest (with Roundup)…These are not Roundup ready so the crops dies. And that’s the intention…to hasten the harvest… Nobody thinks it’s toxic…And we have the celiac disease epidemic…and all these gluten free sections showing up in the grocery stores. I think this is directly due to Roundup residue in the wheat.”

Dr. Seneff’s 2013 paper called Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance found that:

“Deficiencies in tryptophan, tyrosine, methionine and selenomethionine associated with celiac disease, match glyphosate’s known depletion of these amino acids”… contributing to anxiety and depression.

The paper ends with this plea:

“We conclude with a plea to governments to reconsider policies regarding the safety of glyphosate residues in foods.”

Join us on The Anxiety Summit to hear the whole interview (and hear 20+ other experts share research, nutritional pearls, food advice and protocols)

  • Why glyphosate is sprayed on wheat right before the harvest, and how this explains the epidemic in gluten intolerance
  • How glyphosate disrupts gut bacteria causing a deficiency in beneficial bacteria and an overgrowth of pathogenic forms
  • How glyphosate depletes minerals like cobalt, zinc, molybdenum, and manganese by caging them; and how it depletes serotonin and GABA levels
  • How glyphosate disrupts cytochrome P450 enzymes in the gut and liver, with devastating consequences

The Anxiety Summit is a free online virtual event that runs June 9 to June 22 and will be bringing together experts from all over the world – to share nutritional approaches to end anxiety, social anxiety, panic attacks and OCD. Get access here www.theanxietysummit.com

UPDATE: the summit concluded on Tues 6/24 – season 2 of The Anxiety Summit will be in November 2014. If you’d like to be on the notification list just sign up here www.theAnxietySummit.com