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autism

Associations between Parental Anxiety/Depression and Child Behavior Problems

June 10, 2018 By Trudy Scott 2 Comments

In my interview on the Autism, ADHD and Sensory Processing Disorder Summit (June 11 to June 20, 2018) I discuss Self-care strategies for parents that are stressed out, anxious and depressed – without using medications.

You may think “why do I need research to show what I already feel and know?” but I can share that many of the moms I’ve worked find this validating and almost a relief to know they are not alone in this.

The paper, Associations between Parental Anxiety/Depression and Child Behavior Problems Related to Autism Spectrum Disorders: The Roles of Parenting Stress and Parenting Self-Efficacy reports that

Parents of children with autism spectrum disorders (ASDs) have been shown to experience increases in stress, depression, and anxiety, which are also associated with child behavior problems related to ASDs.

The paper lists some reasons for the increased parental stress, anxiety and depression:

  1. First and foremost, the realization that there is no cure for the disorder may serve to increase parenting stress.
  2. Aspects of the child’s behavior, specifically socially inappropriate and aggressive behaviors typically associated with ASD, have been found to be associated with increases in parenting stress… due to a lack of understanding of ASD
  3. Additionally, raising a child with ASD typically involves allocating extra time to meet the needs of the children.

This event addresses all of the above and more by providing you with insights and tools on how to recover your child using a biomedical and nutritional approach together with traditional behavioral models (#1 addressed). This event also helps you understand what some of the underlying causes of socially inappropriate and aggressive behaviors may be – like pyroluria and low serotonin and gluten issues (#2 addressed). And finally, the planning resources that Tara offers via her coaching program help you manage your time while you’re figuring all this out (#3 addressed).

And as an added bonus you get my nutritional advice to help make you more resilient and better able to handle the stress and worry that comes with parenting a cild with ASD or other developmental disorder.

As always, I share about the amazing amino acids that provide anxiety-relief and end the overwhelm, spinning mind, second guessing from day one while you’re figuring everything else out.

In my interview (which airs on day 1), I share:

  • How amino acids can provide instantaneous relief to symptoms of anxiety
  • Low serotonin anxiety, what are the symptoms, and what nutrients can help
  • Low GABA anxiety, how to identify and how to help
  • How to trial amino acids to see if they can help you (and your child)
  • How caring for a child with a neurodevelopmental disorder can be equivalent to combat and result in a form of PTSD
  • B vitamins and adaptogenic herbs for PTSD nutritional support
  • The benefits of a ketogenic diet for caregivers and our children
  • How collagen can actually make anxiety, depression and insomnia worse.
  • EMFs role in our health and how they are contributing to our stress.

This event brings together 30+ of the leading doctors, nutritionists, and researchers working to help parents by sharing the latest information and strategies for achieving recovery for children with Autism, ADHD and Sensory Processing Disorder.

Having a child with Autism, ADHD or Sensory Processing Disorder is challenging. Figuring out what to do to help them is just as challenging. Join us for 10 days of eye-opening information into the root causes of your child’s neurological dysfunction. Imagine learning about what may have caused their symptoms and how to address them with nutrition and biomedical approaches and leverage the power of positive neuroplasticity to improve function, health, and their lives.

Anxiety, stress, depression and PTSD-like symptoms are common in any caregiver situation, so even if you don’t have a child with a neurological disorder, this may be of interest to you if you are taking care of an older parent, a sibling, a spouse or expect to in the near future.

Register for the summit here

Hope to see you there.

Filed Under: Autism, Children, Events Tagged With: ADHD, amino acids, autism, PTSD, Self-care, spd

KetoNutrition: From Science to Emerging Applications and Practical Implementation

May 4, 2018 By Trudy Scott Leave a Comment

I had the pleasure of hearing Dominic D’Agostino, NASA crew member, researcher and Associate Professor at the University of South Florida present on “KetoNutrition: From Science to Emerging Applications and Practical Implementation” at the 6th BioCeuticals Research Symposium in Melbourne last weekend. His presentation was based on decades of evidence that supports the anticonvulsant and neuroprotective properties of nutritional ketosis. It was one of my favorite presentations and I’m thrilled to share some of the highlights with you here.

Ketones are alternative fuels and neuroprotective signaling metabolites – increasing longevity, lowering inflammation, dampening oxidative stress, lowering glutamate and raising GABA.

In this slide he shared how the proven applications of nutritional ketosis are extensive – including epilepsy, type 2 diabetes, weight loss, NAFLD, mitochondrial disease and inflammation, GLUTID Syndrome, PDH Deficiency, Lennox-Gastaut Syndrome, Dravet Syndrome and Rett Syndrome.

There is emerging evidence for acne, PCOS, exercise performance, wound healing, longevity, cancer, CNS Oxygen Toxicity, autism, Angelman’s Syndrome, ALS, MS, Neuropathies, Alzheimer’s disease, brain injury, neurodegeneration, anxiety, depression, bipolar and schizoaffective disorder.

Seizures, cancer and the ketogenic diet

 

In his TEDx talk from 2013 Dr. D’Agostino shares the benefits of a ketogenic diet for seizures and how while studying the effects of gasses on the brains of Navy Seal divers, he developed an approach for metabolically starving cancer cells through diet and compressed oxygen, replacing chemotherapy, surgery, or radiation.

He ends by saying this:

Future treatments and prevention of many diseases may fall back on the ancient wisdom of Hippocrates when he said “let food be thy medicine”

As you can see from the applications slide above, much more research has been done on the therapeutic benefits of a ketogenic diet since this 2013 TEDx talk.  And food truly is medicine!

In one of his studies, the first paper above, ketone supplementation was found to have an anti-anxiety effect – Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats:

We conclude that ketone supplementation may represent a promising anxiolytic strategy through a novel means of inducing nutritional ketosis.

Adenosine and the adenosinergic mechanism

He shared a number of studies that describe how the anti-anxiety and anti-convulsant effects of ketone supplementation are mediated, in part, through the adenosinergic mechanism. This was one of his papers – Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats.

Adenosine is a neurochemical which many coffee-drinkers may be familiar with since: “Caffeine increases wakefulness [and often anxiety] by antagonizing adenosine receptors, and adenosine itself promotes sleepiness” and a feeling of calm.

Older research finds that there is the “involvement of adenosinergic receptor system in anxiety related behaviours.” More recent research describes adenosine as “a mediator with multisystemic effects”, and it is produced by almost all cells, playing a role in heart function, sleep, bone health, activation of the immune system and mediating the effect of various hormones. I expect we’ll be hearing a great deal more about adenosine in relation to ketogenic diets in the near future.

The microbiomes of astronauts sync up and so do their serotonin levels

This was one of my favorite presentations at the BioCeuticals Symposium and it was really great to meet Dominic afterwards and learn more about future anxiety research. He shared that his lab has planned research on the benefits of ketosis for both anxiety and improved cognitive function.

It was also fascinating learning from someone who has been in space and hearing how the microbiomes of the astronauts sync up when they are all in space together. And so do their serotonin levels.

If the ketogenic diet is new for you or you want to see the latest research, check out Dominic’s work at Keto Nutrition. And if you want to learn more from Dominic and other keto experts, the Keto Edge Summit runs all of next week.

I also write about two schizoaffective case studies here and share questions and concerns I have about the ketogenic diet. It’s not a panacea for everyone in all instances. But the therapeutic benefits are profound when someone needs to adopt this dietary approach.

Feel free to ask questions and share you experiences with a ketogenic diet – in the comments below.

Filed Under: Anxiety, Bipolar disorder, Ketogenic diet Tagged With: adenosine, adenosinergic, anxiety, autism, cancer, depression, Dominic D'Agostino, keto, Ketogenic diet, ketosis, schizoaffective disorder, seizures, weight-loss

Smart pills: sensors, copper, silicon and EMFs in medications?

January 19, 2018 By Trudy Scott 1 Comment

Can you discuss the new copper and silicon microchip they are starting to use in Abilify and other bipolar and schizophrenia medications? This subject has been in the news.

The above question was posted on a recent blog – Copper toxicity: anxiety, phobias, ADHD on the Heavy Metals Summit

This was new to me and at first glance I didn’t like the sound of copper and a microchip in a medication, so I went looking for information.

Before I share my findings, here is a quick overview of Abilify/Aripiprazole and the FDA-Approved and Off-Label Uses: originally approved for schizophrenia and then approved for bipolar disorder, approved ‘as adjunctive treatment for major depressive disorder’ and also approved for irritability in autism spectrum disorders.

The above article also lists off-label use of Abilify which includes the following: generalized anxiety disorder, social phobia, ADHD, dementia, insomnia, OCD, PTSD, substance abuse and Tourette’s syndrome.

Dr. Mark Hyman actually mentions off-label use of antipsychotics like Abilify in the Broken Brain docuseries. He discusses their use in children:

there’s pushing of medications for off-label use, which means that they’re not approved for those indications. They’re doing this for kids with antipsychotics, and they’re actually being sued. The pharma companies have been held liable for promoting these drugs for off-label uses for kids, which they’re not allowed to do. They get fined billions of dollars, but they don’t care because they’ve made umpteen more billions, and they just see it as a marketing expense.

What are these ‘smart pills’?

This article, ‘smart pill’ can help patients remember their meds explains more about these new smart pills:

Chicago’s Rush University Medical Center has become one of the few health care providers in the United States to use a grain-of-sand-sized sensor that, after being swallowed, can alert patients when they’ve forgotten to take medication.

Developed by Proteus Digital Health, the FDA-approved sensor is made from microscopic quantities of copper and magnesium. Powered by the human body (no batteries or antennas required), the tiny sensor turns on after reaching patients’ stomachs, where it begins sending signals to a Band-Aid-like, Bluetooth-enabled patch worn on the torso. The patch then decodes those signals into meaningful health information and sends it to users and physicians in an app.

Here is the press release about these ‘smart pills’- Otsuka and Proteus® Announce the First U.S. FDA Approval of a Digital Medicine System: Abilify MyCite® (aripiprazole tablets with sensor)

This was approved by the FDA for use in U.S. in 2012. The microchip is actually made of copper, magnesium and silicon, and reacts with stomach juices when swallowed along with the medication. According to the above article:

Once the microchip has done its job, it dissolves and passes out of the body along with other digested food.

However, another article on the introduction of these smart pills into the UK doesn’t seem to reach the same conclusion:

What’s not clear is how long the microchip operates inside the body, and what happens to it once it dies. Is it digested, or is it flushed out into the sewer system wholly intact? And if it’s flushed, what happens to all those millions of chips that wind up in sewage treatment facilities?

Some of my concerns

I have no idea what the long-term implications of this ‘smart pill’ technology will be and would hope patients are being informed now, will be informed in the future, and will have a choice as to whether or not they want to use ‘smart’ medications like this.

Here are some of my initial concerns I’d like to share:

  • the adverse effects of added copper in the body (implications for dementia and Alzheimer’s disease, and anxiety and autism)
  • the adverse health effects of Bluetooth/EMFs for the person ingesting a ‘smart pill’ and for those around them (the new book The Non-Tinfoil Guide to EMFs by Nicolas Pineault is the most current resource for all things related to EMFs)
  • the adverse effects of silicon in the body
  • the harmful environmental impacts once these get into the sewer system
  • the added costs of these medications
  • how quickly we’ll start to see this technology used in more and more medications
  • lack of awareness for the consumer in terms of adverse health impacts and privacy concerns

Without going into the myriad of issues with off-label use of atypical antipsychotics and all the functional medicine and nutritional approaches that can be used to address anxiety (such as tryptophan), social phobia (such as low zinc and low vitamin B6), ADHD (such as gardening or low iron), OCD (such as a gluten-free diet or inositol), insomnia (such as GABA and 5-HTP) and PTSD, we now have the added concerns of what problems these ‘smart pills’ may contribute to.

I say let’s be smart about this and rethink these ‘smart pills’ and ideally look for functional medicine and nutritional solutions instead of using antipsychotics off-label.

And even if we look at some of the approved uses of antipsychotic medications, case studies report a nutritional psychiatry approach for this. Dr. Georgia Ede, MD, shares two schizoaffective cases in her article: Low-Carbohydrate Diet Superior to Antipsychotic Medications. These were patients of Dr. Chris Palmer, a psychiatrist from Harvard’s McLean Hospital in Belmont, Massachusetts. They both tried a ketogenic diet for weight loss. Here are the results the woman patient experienced:

After four weeks on the diet, her delusions had resolved and she’d lost ten pounds. At four months’ time, she’d lost 30 pounds and her score on a clinical questionnaire called the PANSS (Positive and Negative Symptom Scale), which ranks symptoms on a scale from 30 (best) to 210 (worst), had come down from 107 to 70. 

The male patient experienced similar results with “dramatic” reductions in auditory hallucinations and delusions, as well as better mood and energy. He also lost weight, losing 104 pounds over the course of a year.  As Dr. Ede writes:

These outcomes are truly remarkable: improvement by dozens of points on the PANSS, significant weight loss, and better quality of life. There simply is no psychiatric medication available with the power to accomplish those results.  

And in this instance and others like them we won’t have the ‘smart pill’ issues.

Have you ever been prescribed Abilify or one of the other antipsychotics? And for what symptoms?

Has your doctor ever offered you the ‘smart pill’ option?

Have you worked with clients or patients who have been prescribed these medications?

Filed Under: Antianxiety Tagged With: Abilify, antipsychotics, anxiety, autism, copper, depression, EMFs, off-label, smart pill, smart pills, social phobia

GABA and tryptophan for pain and anxiety in Parkinson’s disease?

August 25, 2017 By Trudy Scott 5 Comments

Last week I blogged about my recent back injury and how acupuncture boosts GABA to reduce back pain and how oral GABA further reduces the pain. Both these interventions have helped me so much and I’m doing so much better.

I love the feedback I receive in the blog comments and the great questions – which get to help the person asking the question and everyone else reading the blog and comments. So thank you if you comment!

I received this lovely feedback about GABA and anxiety, and a question about Parkinson’s disease (on the above blog) and want to share it and my response here so you and families with a loved one with Parkinson’s disease will also have access to this information:

I have loved reading your articles for a long time and listen to you whenever you are on a summit. I have learned a lot. GABA definitely helps me to relax, reduce my monkey mind and sleep better.

My mom has Parkinson’s disease and is very stiff and tight. She hurts often, especially her back. She also has afternoon anxiety, some call it “sundowners”. Can she take GABA with carbidopa-levidopa and blood pressure meds? She needs some kind of help!

Thank you in advance for any suggestions you might have to give her any quality of life as right now it is not good and the doctors offer no suggestions beyond possibly more prescriptions.

I responded saying how glad I was to hear GABA helps her to relax, reduces her monkey mind and also helps her to sleep better and how sorry I was to hear about her mom’s stiffness, pain and anxiety.

I posted this regarding the stiffness and back pain: share this paper with your doctor and get his/her approval to do a trial of GABA – Parkinson’s Disease and Neurodegeneration: GABA-Collapse Hypothesis:

the original description of Parkinson’s disease (PD) as due to the selective damage of dopaminergic neurons in the mesencephalon should be updated into the concept of a severe multisystemic neurodegenerative disorder of the nervous system, whose clinical symptoms reflect the localization and progression of the most advanced GABA pathology. A future and more complete therapeutic approach to PD should be aimed first at slowing (or stopping) the progression of Ca(2+)/GABA functional decline.

I have worked with a few people with Parkinson’s disease and GABA has been very helpful for the stiffness and pain, the physical anxiety, easing some of their tremors and helping with insomnia. I always do a trial so we know how much the individual will need.

For someone on blood pressure medication I’d start with a GABA-only product or GABA-theanine product rather than GABA Calm which does contain tyrosine.

I posted this regarding the “sundowners” question: I’d share this with your doctor and get the approval to do a trial of tryptophan – Sundown Syndrome in Persons with Dementia: An Update

sundown syndrome is characterized by the emergence or increment of neuropsychiatric symptoms such as agitation, confusion, anxiety, and aggressiveness in late afternoon, in the evening, or at night.

Although this paper refers to dementia, these symptoms also happen to be classic low serotonin symptoms that typically respond really well to tryptophan. The paper mentions melatonin as an intervention but since tryptophan converts to melatonin I’d start with tryptophan (based on doing a trial) and then consider adding melatonin too if needed.

I shared a few more resources on Parkinson’s disease:

  • Chris Kresser has an excellent blog post called New Research and Treatments for Parkinson’s Disease where he writes about the microbiome, constipation, SIBO, gluten, the HPA axis, low-dose naltrexone (LDN) and the possible autoimmune aspect, iron overload and the benefits of curcumin, a ketogenic diet and glutathione.
  • The Wahls Protocol for MS (some versions of which are ketogenic diets) shows promise for many neurodegenerative diseases and is also being researched for Parkinson’s disease

I also shared this amazing and inspiring video created by physical therapist Anicea Gunlock, on how using music while gait training can be beneficial for those suffering from Parkinsons’s disease

You read more about this music approach Anicea Gunlock used with her patient here.

The amino acids GABA and tryptophan can often be used in conjunction with all of the above approaches and often provide immediate relief for anxiety, pain, agitation and insomnia while some of the other root causes are being addressed.

I’ve recently updated the Antianxiety Food Solution Amino Acid and Pyroluria Supplements blog with some of my favorite GABA and tryptophan products mentioned above. You’ll also see the amino acid questionnaire and amino acid precautions on this blog.

Instead of only considering the amino acids for someone whose primary issue is anxiety, I’d like you to start thinking about using the amino acids for anyone who has a medical diagnosis – such as autism, cancer, ALS, Parkinson’s disease, MS, Alzheimer’s disease or anything else – and who also happens to suffer from anxiety.

Have you used GABA or tryptophan to ease stiff and tense muscles and pain in your Parksinson’s disease, for a family member or for a patient/client?

And have you used tryptophan for the low serotonin worry-type of anxiety, agitation and insomnia?

Filed Under: Anxiety, GABA, serotonin Tagged With: agitation, anxiety, autism, GABA, MS, pain, Parkinson's disease, serotonin, stiff and tense muscles, sundowners, tryptophan

OCD, anxiety, PANDAS and PANS: Dr Brandon Brock

June 18, 2017 By Trudy Scott 6 Comments

This is a quick reminder that The Autism, ADHD and Sensory Processing Disorder Summit starts tomorrow.

I really enjoyed Dr. Brandon Brock’s interview, Understanding PANS and PANDAS role in ASD, ADHD and SPD, and it is particularly relevant for anxiety and OCD. During the interview he describes what he often finds with these children with PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) and PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections):

A lot of times the child may come in having nightmares or they just start bed wetting or they’re having fears or a little bit of irritability and they get blamed on all kinds of things. You know they get blamed on maybe a sketchy home environment that’s really not that sketchy, or maybe they just say it’s normal for a child to go through this, or maybe they’re just starting to hit puberty so they’re getting more aggressive. In other words there’s always a reason other than looking at the brain physiology. Why is it changing? Is the brain physiology changing because maybe there is an environmental factor? You know maybe there is some abuse or something. And that does happen.

But on a bigger scale maybe they had some sort of infectious disease, or maybe they had a toxin that got into their body, and it made their immune system react, and it started giving them symptoms like abnormal movements, ticks, especially in the face, lip smacking, hair twirling.

He talks about how these immune reactions to the brain and basal ganglia cause symptoms:

So when you have an immune response against the basal ganglia it’s kind of like pushing the play button over and over and over again. So now we see things like obsessive compulsive disorder, we see tics, we see choreiform movements [repetitive and rapid, jerky, involuntary movement that appears to be well-coordinated], we see nightmares and bizarre thoughts, or the kid does something that we call a perseveration. It is the repetition of a particular response (such as a word, phrase, or gesture), so they say something over and over and over. So there’s a fine line between a kid being a kid and then a kid having something like PANDAS. And really what we call that is auto-immune encephalitis, which just means inflammation of the brain. So the kid’s brain really is kind of like, if you want to say it metaphorically, on fire.

Dr. Brock talks about the 2 strep tests or anti-streptococcal antibody titers that are commercially available and determines whether the child has had a previous strep infection:

  • Antistrepolysin O (ASO) titer,* which rises 3-6 weeks after a strep infection, and
  • Antistreptococcal DNAse B (AntiDNAse-B) titer, which rises 6-8 weeks after a strep infection.]

In addition to the many other labs tests they do, he goes on to discuss another whole set of antibodies that can become positive down the road:

Dopamine antibodies, calcium calmodulin mechanisms, and then all of the intra-cellular structures, like the tubulin structures, the alpha and beta tubulin structures, the micro-tubulin structures, and even the cell wall. So we have an antibody panel that really says it’s either the structure, it’s either the receptor, or it’s the actual pumping mechanism that makes dopamine.

He didn’t mention this but it’s the Cunningham Panel done by Moleculera Labs

Dr. Brock goes on to talk about functional neurology, diet, how to find a good practitioner and much more. It’s a great interview!

The Autism, ADHD and Sensory Processing Disorder Summit, hosted by Tara Hunkin, NTP, runs from June 19-28, 2017.

It will be 10 days of eye opening information into the root causes of your child’s neurological dysfunction. Imagine learning about what may have caused their symptoms and how to address them with nutrition and biomedical approaches and leverage the power of positive neuroplasticity to improve function, health and their lives.

As I mentioned in the prior summit announcement many of the interviews on this summit may be applicable for you even if you don’t have a child with a sensory processing disorder, ADHD and/or autism – many of my clients with anxiety often benefit from the biomedical support that many of these speakers are addressing. Simply replace sensory processing disorder, ADHD and/or autism with anxiety and listen and learn.

And if you’re new to my work, do also tune into my interview: Anxiety’s Role in ASD, ADHD and SPD and how nutrient therapy can help.

Here are a few other speakers and their interesting topics (and I can’t wait to hear them all):

  • David Perlmutter, MD: The role of the microbiome in neurological health.
  • Alex Doman: Using music to heal your child’s brain
  • Derrick MacFabe, MD: The role of propionic acid in the multi-system challenges found in ASD.
  • Sonia McGowin, DC: How to know if biomedical intervention is right for your child.

You can register for The Autism, ADHD and Sensory Processing Disorder Summit here

Filed Under: Autism Tagged With: ADHD, anxiety, autism, Brandon Brock, OCD, PANDAS, PANS, Sensory Processing Disorder, strep, Tara Hunkin

Low-dose suramin in autism disables cell danger response: leads to speech, calm, focus and play

June 9, 2017 By Trudy Scott 10 Comments

I’m fascinated and excited by this new research on cell danger response (CDR): Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial abstract and the ramifications for autism as well as anxiety and other chronic health conditions. This recent study was double-blind, placebo-controlled and involved 10 boys, ages 5 to 14 years, all diagnosed with autism. Five of the 10 boys received a single, intravenous infusion of suramin and the other five boys received a placebo.

As reported in this Science Daily summary: Century-old drug as potential new approach to autism, the results seen in two of the autistic children after a single low dose of the 100 year old medication was profound:

The six-year-old and the 14-year-old who received suramin said the first sentences of their lives about one week after the single suramin infusion.

The most changed behaviors in all of the five boys who received the suramin were: 

social communication and play, speech and language, calm and focus, repetitive behaviors and coping skills.

One of the parents of a 14 year-old who had not spoken a complete sentence in 12 years said this:

We saw improvements in our son after suramin that we have never seen before.

Within an hour after the infusion, he started to make more eye contact with the doctor and nurses in the room. There was a new calmness at times, but also more emotion at other times. He started to show an interest in playing hide-and-seek with his 16-year-old brother. He started practicing making new sounds around the house. He started seeking out his dad more.

We have tried every new treatment out there for over 10 years. Nothing has come close to all the changes in language and social interaction and new interests that we saw after suramin. We saw our son advance almost three years in development in just six weeks.

I can’t even begin to imagine the joy these parents must have felt to see their children respond like this!

Unfortunately the therapeutic benefits of suramin was temporary and the benefits gradually faded after several weeks as the effects of the drug wore off.

Suramin is used for African sleeping sickness and river blindness, which are caused by parasites and does have some very serious side-effects when used at higher doses (in AIDS research in 1987 sixteen patients died while receiving suramin or within three weeks of discontinuation of drug therapy).

In this autism study the children received a single very low dose intravenous infusion which did cause a rash.

The authors do acknowledge that suramin isn’t the solution but rather a way to test the cell danger hypothesis as a “possible unifying theory” that contributes to the cause of autism (and other chronic conditions that don’t resolve).

So what does the cell danger response actually mean? It’s taken me a fair bit of reading to understand it so let me share this explanation from one of the earlier mouse studies done by lead researcher Robert K. Naviaux, MD, PhD:

When cells are exposed to danger in the form of a virus, infection, toxin, or even certain genetic mutations [or traumas], they react defensively, shutting down ordinary activities and erecting barriers against the [real or] perceived threat. One consequence is that communication between cells is reduced which …may interfere with brain development and function, leading to autism [and other chronic conditions]

Even when the danger is no longer there – the infection or toxin or trauma has been removed, the diet has been changed, the nutritional imbalances have been addressed, the inflammation has been reduced etc. – the cells stay in danger mode and are not able to communicate and do what they need to do.

By using suramin the cell danger response/CDR signal is blocked or disabled or switched off so the cells no longer see the perceived danger, allowing cells to restore normal communication and function, and symptoms are reversed.

A simple way to think of it is like this: like a bear, the cells are in hibernation because it’s winter and when summer comes around they stay in hibernation because they still think there is the danger of winter or the lack of food. This is the cell danger response and the cells are stuck. The suramin tells the cells it really is summer, there is plenty of salmon and berries and it’s safe to come out of hibernation.

This approach is called antipurinergic therapy or APT and research shows it has applications for a number of conditions. These are disorders corrected or improved by antipurinergic therapy:

(table from Metabolic features of the cell danger response)

I’m excited about the amazing results in these children and about the promise of what this holds. But I do still have so many questions about this research and look forward to learning more and sharing more with you as I do:

  • Why was suramin used and is there a safe drug that could achieve the same results?
  • Or rather, what natural herb and/or nutrient/s can achieve the same or similar results without the side-effects?
  • What is planned for future CDR research for children with autism and for other conditions? (I do know Dr. Naviaux is planning CFS research later this year)
  • What role does vitamin B6 and serotonin play in all this? (the cell danger response yields vitamin B6 deficiency)
  • Could there be applications for anxiety for you if you have tried ALL the nutritional/biochemical approaches and are still not seeing symptom resolution?
  • Could this mechanism help you if you’ve been harmed by benzodiazepines, SSRIs and/or fluoroquinolones and can’t take any supplements?
  • Could this mechanism help when you have a combination of many stresses like past trauma, genetic defects, heavy metals, mold and Lyme, as well as gut issues and nutritional imbalances?

Feel free to share insights and questions in the comment box below.

Filed Under: Autism Tagged With: autism, suramin

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