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5-HTP can raise salivary cortisol: does this cause a “wired-tired” feeling?

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5-htp salivary

Are you aware that 5-HTP – an amino acid supplement that supports serotonin levels – can raise cortisol levels and leave you feeling “wired-tired”? You may be able to relate to this if you’ve ever used 5-HTP to help with anxiety and insomnia and ended up feeling more anxious and more wide-awake despite your exhaustion and need for sleep. You feel “wired-tired” and it’s not pleasant at all.

Both 5-HTP and tryptophan, used as supplements, help to boost serotonin levels so you can feel happy, calm, sleep well and not crave carbs in the afternoon/evening. They also help with panic attacks and phobias, lack of confidence, depression, negativity, imposter syndrome, PMS, irritability, anger issues, pain/fibromyalgia, TMJ and anger. I typically have my clients with low serotonin symptoms start with a trial of tryptophan because I see such excellent results with this amino acid. That being said, some people simply do better on one versus the other and you may do better with 5-HTP.

However there is one big caveat with 5-HTP. I don’t recommend 5-HTP when a client has elevated cortisol levels because we know that it can raise cortisol levels in certain individuals. This can leave you feeling agitated, cranky, as well as wired and yet tired at the same time.

In this 2002 study, L-5-hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers

Salivary cortisol levels were measured in 24 panic disorder patients and 24 healthy volunteers, following ingestion of 200 mg L-5-hydroxytryptophan or placebo.

The experiment was carried out in the afternoon, “when basal cortisol secretion is more stable.” The first saliva sample was obtained at 1pm and the subjects ingested the 200mg 5-HTP at 2pm. Additional saliva samples were obtained at 2:30pm, 3:00pm and 3:30pm.

They report the following:

A significant rise in cortisol was observed in both patients and controls following ingestion of L-5-hydroxytryptophan. No such effects were seen in the placebo condition.

Here are a few additional comments and my thoughts:

  • This study was done to find evidence for “serotonin receptor hypersensitivity in panic disorder” and not specifically to test for the effects of 5-HTP on cortisol levels but it serves this purpose rather nicely (and it’s one of many similar studies, some of which measure plasma cortisol levels)
  • Keep in mind 200mg of 5-HTP is a large starting dose. It’s typical to start with 50mg so may be a factor to consider
  • In this study they did not assess cortisol levels beyond the 1.5 hours from ingestion of the 5-HTP. It would have been useful to see when levels started to go down
  • We would want to consider the ramifications of using 5-HTP for weeks (whether it’s 50 or 200mg). What impact would that have on cortisol and the adrenals? (I am not aware of a study like this having been done)
  • I’m also not aware of a study being done with 50mg but if you feel worse and feel “wired-tired” with 5-HTP and switch to tryptophan (the equivalent starting dose is 500mg) and your anxiety and other low serotonin symptoms resolve then you have found your solution
  • You may be wondering: “could I use 5-HTP to raise my low cortisol levels”? Theoretically yes and possibly very short-term. But I would question the timing since 5-HTP and tryptophan are best dosed mid-afternoon and later. This is when we would expect our cortisol levels to be on the downward slope as we end our day. I’d also want to nourish the adrenals with B vitamins and herbal adaptogen and remove the trigger/s that are leading to low cortisol.

If you suspect low serotonin symptoms and are new to using the amino acids and do not have my book I highly recommend getting it and reading it before jumping in to taking supplements: The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings.

There is a complete chapter on the amino acids and one for pyroluria, plus information on real whole food, sugar and blood sugar, gluten, digestion and much more.  If you’re not a reader there is now also an audible version.

Here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution and additional information on Anxiety and targeted individual amino acid supplements: a summary

Please also read and follow these Amino Acid Precautions.

This lists The Antianxiety Food Solution Amino Acid and Pyroluria Supplements that I use with my individual clients and those in my group programs.

Have you used 5-HTP with success? Or have you used it and felt “wired-tired”? Have you correlated the success or failure of your 5-HTP use with your salivary cortisol levels?

If you switched from 5-HTP to tryptophan did you have success with that?

If you’re a practitioner is this something you see with your clients/patients and take into consideration?

Feel free to post your questions here too.

Copper toxicity: anxiety, phobias, ADHD on the Heavy Metals Summit

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One of my favorite functional medicine practitioners, Ann Louise Gittleman covers the issue of excess copper on the Heavy Metals Summit, which airs online Jan 29 to Feb 5, 2018.

The topic is – Copper: The Double-Edged Sword – and she shares how copper is probably the most insidious of the toxic metals:

I think what lead was to the ancient Romans, copper is to modern day Americans. And I think it may be the fundamental cause of many of our orphan illnesses, our mystery illnesses, and debilitating and aging biochemical imbalances.

She shares some of the sources of copper that are most prevalent in contributing to excess copper levels and toxicity:

I think first and foremost we have to look at copper plumbing, copper cookware, which is all the rage in this day and time. There’s naturally occurring copper in water. Birth control pills can be a source of copper, because of excessive amounts of estrogen and estrogen is connected to copper the way zinc is connected to progesterone.

There are copper IUDs that are very popular amongst so many of our young women. Even dental amalgams, if they are put in your mouth post 1976 can have a very high copper amalgam percentage. And then, of course, there are fungicides for swimming pools and foods. So that’s just the beginning.

Then there’s the copper that you’re getting in common foods. Whether it’s soy; whether it’s GMO soy or not. You’re getting that in tempeh, tofu, soy protein powders. Nuts and seeds, like cashew nuts and sesame seeds. Avocados; a very healthy fat, but high in copper nevertheless. And some of our shellfish. Then you’ve got your regular tea, your green tea, your white tea, your black tea, your bran, and even your brewer’s yeast.

One of the biggest factors that I see contributing to high copper in my clients who have low zinc and anxiety, is all the baking being done with nuts flours such as almond flour! The next two areas I see as being most problematic for women, is the birth control pill and copper IUDs.  

Ann Louise talks about how excess copper can affect you: hyperactivity and ADD, thyroid issues, tooth decay, dementia, urinary tract infections, candida and functional hypoglycemia.

She also covers the following anxiety symptoms, which I commonly see in my clients and community: nervousness, phobias and unresolved fears, depression and even stuttering.

Here are my contributions to this important discussion:

  • High copper and low zinc (because these two balance each other out), is one of the most common imbalances I see in my community of anxious individuals, and especially in women because of the hormonal influence.
  • Other than removing the source of the copper, one way to address this is via zinc supplementation. If anxiety is a factor, addressing low serotonin and low GABA with amino acids like tryptophan and GABA helps until zinc increases and copper decreases.
  • Good levels of zinc are also needed to make the neurotransmitters so once levels rise (as we get rid of excess copper) we can start to make our own.

Wendy Myers, Christine Schaffner, ND, and Dietrich Klinghardt, MD, PhD, have spent the last few months gathering the right experts, information and protocols to help you understand the danger of heavy metals like copper, mercury, lead, cadmium and others, and what to do about them.

Every day, they help their patients regain health, in some part through heavy metal detoxification. People with incorrect diagnoses of multiple sclerosis, fibromyalgia, anxiety and depression, insomnia, or thyroid issues, just to name a few, have found relief through innovative and individualized protocols to reduce the burden of heavy metals.

Register here to join us on The Heavy Metals Summit January 29 – February 5, 2018. See you on the summit! I know I’m going to learn a lot too!

Have you had issues with high copper and low zinc?

Feel free to comment or post a question below.

The Antianxiety Food Solution: This Book Is a Total Game Changer!!

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I write multiple blogs each week and the website is a wealth of information (be sure to check the comments too – I love the community feedback and questions and learn so much from you!) BUT the foundation of all that I teach and how I work with my anxious clients is outlined in great detail in my book The Antianxiety Food Solution, so I recommend this essential reading to make the basic food changes (for some people that’s all they need to do), and before using any of the nutrients, and especially before using targeted individual amino acids.  

Valerie Gangason posted this wonderful review on Amazon recently: This Book Is a Total Game Changer!!

If you have anxiety, panic attacks or phobias, read this book. It’s an eye opener and a complete game changer. It pushed me to re-evaluate the way I eat and to make some serious shifts in my life. FYI-sugar is the devil

I love the comment about sugar being the devil and commend her for re-evaluating how she eats and for making those serious shifts. It’s how you get results and I ever get tired of feedback like this.

Grab your copy from Amazon here if you don’t yet have it. If you already have a copy I’d love a review on Amazon please! And if you have an older copy with no index you can grab a copy of the index here

Feel free to share your great results or ask questions in the comments.