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Amino Acids

Glutamine supplementation: cancer concerns and benefits

By Trudy Scott 128 Comments

russell-blaylock

In the recent Truth About Cancer docu-series hosted by Ty Bollinger, founder of Cancer Truth, interviewed Dr. Russell Blaylock, M.D. and Dr. Blaylock said no to glutamine supplementation because it feeds cancer like sugar.

Here is what Dr. Russell Blaylock said during Episode 4 – Excitotoxins that Fuel Cancer:

Cancer cells use two major fuels, they use glucose and they use glutamine. Of the two, glutamine is the more powerful stimulant for cancer cell growth.

The Warburg effect is the fact that normal cells use both anaerobic and aerobic system, the Krebs cycle. The cancer cells only use the anaerobic system, it was thought. Glutamine can work the aerobic system and product a lot more energy. So if you’re eating a lot of sugar and you’re eating a lot of glutamine, you’re really stimulating your cancer powerfully. So the idea is you want to cut down your glutamine intake. A lot of people are promoting glutamine as a way to heal the gut—the leaky gut syndrome. So, they’re saying, take five, six, ten grams of glutamine. That is a powerful stimulant for degenerative brain disorders, a powerful stimulant for cancer growth. You don’t want to do that. There’s a lot better ways to repair the GI tract—they work better and safer and actually inhibit cancer.

Dr. Blaylock, author of Excitotoxins: The Taste That Kills, has been saying this for years. His coverage of MSG and how harmful it is, is very powerful groud-breaking work but many practitioners disagree with his glutamine-feeding-cancer comments.

As a result of this recent interview I’ve been getting a lot of questions about glutamine because it’s something I use with most of my clients for blood sugar control, carbohydrate/sugar cravings and gut healing.

In order to reassure folks I started looking at the current research and getting feedback from trusted colleagues.

I have now gathered 20+ studies showing glutamine to be beneficial in cancer: it heals the gut, helps boost glutathione, helps with muscle wasting, helps when someone is going through chemotherapy and radiation, and is useful for bone marrow transplants. Studies as far back as 1990 state it has benefits and doesn’t promote tumor growth, with 5 of them published this year.

This 2010 paper Glutamine as indispensable nutrient in oncology: experimental and clinical evidence summarizes many of the benefits:

Within the last two decades, 36 (24 oral/enteral, 12 parenteral) clinical studies evaluating the tolerance, safety and effects of glutamine in various patient groups have been published. In the great majority of these clinical studies, glutamine supplementation in cancer patients improves host metabolism and clinical situation without increasing tumor growth. Potential mechanisms of glutamine effects include maintenance of mucosal integrity, improved immune competence, inhibition of cell proliferation, increased apoptosis rate, increased synthesis of glutathione, induction of heat shock protein synthesis, and increased synthesis of glucagons-like peptides.

In various clinical situations, appropriate exogenous glutamine supply is safe and can beneficially contribute to diminish risks of high-dose chemotherapy and radiation. In addition, there is some evidence that adequate glutamine availability can beneficially affect outcome, especially in patients undergoing bone marrow transplantation.

With new research coming out all the time, a paper published in 2010 may seem very old and yet there are some more recent papers stating similar benefits, many of which were published this year and in 2014.   Here are a few excerpts from some of these papers:

  • Oral administration of [glutamine] plus [elemental diet] may prevent chemotherapy-induced oral mucositis in esophageal cancer patients. Link to paper
  • This study suggests a beneficial role of oral [glutamine] use in prevention and/or delay of radiation-induced esophagitis, in terms of esophageal transit time and serum immunological parameters, as well as weight loss. Link to paper
  • It also appears that glutamine may significantly reduce the duration and severity of objective oral mucositis during radiotherapy. Link to paper
  • These results suggest that [glutamine] is an effective way to reduce radiation morbidity to breast cancer and is associated with the increased expression of a novel serum protein biomarker. Link to paper
  • A promising supplemental therapy agent in the field is glutamine. Glutamine (Gln) is an amino acid that is produced in physiological conditions in human cells. However, in pathological states, glutamine production is often insufficient. In the clinical setting, glutamine has been shown to decrease metabolic side effects resulting from cancer treatment and to improve patient outcome. Link to paper
  • Prophylactic oral glutamine could ameliorate the neoadjuvant chemotherapy-induced increase in intestinal permeability, but had no significant positive clinical effect on stomatitis and diarrhea and did not interfere with the antitumor effect of chemotherapy. Link to paper
  • Oral [glutamine] increased [glutathione] levels and lowered IGF-I and TGF-beta 1 in a range that is considered clinically significant. However, the effect of [glutamine] in maintaining normal gut [glutathione] production in the presence of DMBA was much more significant. Link to paper

I’ve also posted the glutamine-cancer question in a number of online practitioner groups I belong to and have received this feedback:

  • Some practitioners still feel glutamine supplementation is very safe to use up to 10-30g a day for a month and then titrated down to a maintenance dose
  • An integrative cancer doctor says she is more cautious and would not recommend greater than 5g per day if someone has active cancer
  • One practitioner shared that long term studies haven’t shown changes in mortality due to glutamine supplementation in cancer settings but glutamine may be used for fuel by cancer cells
  • Glutamine is not neurotoxic as has been suggested in the book Excitotoxins:The Taste That Kills according to Dr. David Brady and other researchers
  • Many consider bone broth to be safe, some feel bone broth should be avoided during cancer treatments

It’s clearly a controversial topic with very divided opinions and it seems the jury is still out. We are also very individual beings with unique biochemistry so there is never a once size fits all approach and it’s very likely that some won’t benefit from glutamine and some may have adverse effects.

I do list cancer as a possible issue under the glutamine precautions and recommend that you check with your oncologist if you are currently undergoing treatment.

I do want to share safe and valuable information with my clients and with you (my community) and am not afraid to back down and say I was wrong. BUT right now I don’t believe we have enough information to say NO-ONE should be using glutamine as a supplement.   I’m gathering information and feedback, am learning a great deal and will be sharing more in future blogs on this topic. And I hope to get some feedback from Dr. Blaylock himself!

I hope this helps with questions you’ve been having or may have in the near future.

In the meantime I’d love your feedback…

  • If you’re a practitioner I’d love to hear your thoughts and approach, what cautions you offer and do you recommended a safe upper limit?
  • If you’re someone who uses glutamine or has used glutamine what does your practitioner say about it? Have they cautioned you about glutamine? Have they recommended a safe upper limit? What benefits have you seen when using it?
  • If you’ve been treated for cancer, has your cancer team recommended glutamine? And did it help?

UPDATE: Feb 26, 2016 (The post above was originally published on October 30, 2015)

I promised to come back and share additional information from someone working in the area of cancer and so here we are – an update on the glutamine cancer concern:

Paul Anderson ND shared a literature review and practice implications in an called “Glutamine and Cancer: What do we know?” (Update Sept 2021: it was published on Emerson Ecologics but the link is no longer active)

When I read this reassuring literature – based on the 2015 paper, Key Roles of Glutamine Pathways in Reprogramming the Cancer Metabolism. Oxidative Medicine and Cellular Longevity  – I reached out to Dr. Anderson and was given permission to share the link and excerpts from the article:

L-Glutamine the amino acid is one of the most widely used therapeutic substances in natural and integrative clinics as well as some allopathic practices. It has benefit in gastrointestinal illnesses and repair, post-surgical care, renal support, muscle mass maintenance, cachexia and a number of other conditions. Given its wide use in the integrative medical community the concern regarding potential for any adverse or untoward event associated with its use is significant. The primary potential issue is the “feeding” of cancer cells and another related issue is increasing glutathione stores and thereby inactivating standard therapies.

He shares some of the same potential benefits of glutamine that I mentioned above:

  • Post-surgical healing
  • GI repair and maintenance
  • Immune system recovery and maintenance
  • Muscle cell maintenance and recovery
  • Glutathione pool restoration

Dr. Anderson shares that:

the availability of glutamine even in a supplemented person is often too low to do much more than feed the deficient GI cells, so peripheral use is limited with oral doses.

The one common exception is glioblastoma multiforme (GM). In the case of GM, it is theoretically possible that amounts of glutamine that were able to cross the GI barrier could be metabolized in a manner promoting of GM energy and health. In the case of GM the authors point out that restricting carbohydrates would likely make the glutamine effective in an anti-GM biology.

And he shares a number of take home points for clinical practice: oral glutamine supplementation is likely safe across most tumor types in patients with cancer, it’s indicated for GI damage, the timing and doses, and how he uses carbohydrate restriction for certain cancers (when also using glutamine).

Based on his clinical experience Dr. Anderson states that:

Glutamine used appropriately is an excellent adjunctive therapy in the oncology setting.

Dr. Paul S. Anderson is medical director of Anderson Medical Specialty Associates, a clinic focusing on the care of patients with cancer and chronic diseases. Former positions include professor of Pharmacology and Clinical Medicine at Bastyr University and Chief of IV Services for Bastyr Oncology Research Center. He is a graduate of National College of Natural Medicine and began instructing classes at naturopathic medical schools in the early 1990’s. He continues to hold board review classes and CME courses for most of the US and Canadian ND programs. He also is a founding board member of the Academy of Parenteral Therapies specialty group and an instructor and author for the International IV Nutritional Therapy training group.

His book, Outside the Box Cancer Therapies: Alternative Therapies That Treat and Prevent Cancer (here is my Amazon link) discusses glutamine and some of the research and benefits when used with cancer patients, and also recommends consulting with your physician.

Did your oncology medical team recommend use of glutamine while you were in cancer treatment and did it help?

Or did they say no to supplemental glutamine and share why?

Feel free to post additional glutamine questions too.

Tryptophan 500mg or Tryptophan Complete (by Lidtke)?

By Trudy Scott 143 Comments

tryptogold-lidke
Lidtke Tryptophan 500mg and Lidtke Tryptophan Complete (credit: Lidtke)

If you’ve been following me and have read my book The Antianxiety Food Solution and heard me speak at conferences and on summits, you know I have been an avid fan of the Lidtke tryptophan 500mg for years and years because of the quality and because it works SO well for my anxious clients. The Lidtke brand is the ONLY tryptophan I recommend (and I’m not paid to say this) for boosting serotonin levels. You can find it and the other amino acids I use on the supplements blog.

This week I had a great conversation with Ron Sturtz, Owner and product formulator of the products at Lidtke Technologies. We discussed tryptophan in general and concerns about it not going down the serotonin pathway and instead converting to quinolinic acid.

We talked extensively about the Lidtke Tryptophan Complete and why they include vitamin C, niacinaminde, P5P (the active form of vitamin B6), curcumin, lysine, magnesium glycinate, magnesium taurinate and folate (from lemon peel) in the product. As a result of that discussion I now want to learn more about the Lidtke Tryptophan Complete product for you and for my clients.

I’ll be sharing more information with links to the research as to why these ingredients are important in the serotonin pathway but here is the short version: with these ingredients and co-factors less tryptophan is reportedly needed and there is less chance of it going down the wrong pathway to produce neurotoxic quinolinic acid instead of going down the pathway to make serotonin. We obviously want the latter to happen.

I’ve also decided I want to interview Ron on the next Anxiety Summit. The biochemistry is too important not to share. Hearing him say “we are fanatical about safety!” makes me even more of a fan of this company and their products!

Anyway, according to Ron, you should need less of the Lidtke Tryptophan Complete. He shared that 500mg Lidtke Tryptophan is approximately equivalent to 350mg Lidtke Tryptophan Complete, since it has all the co-factors.

I asked for feedback in some Facebook groups I host and got this:

I’ve used the Tryptophan Complete product and actually like it a lot better than the 500mg version. The Tryptophan Complete gave a much deeper state of relaxation and a way more solid sleep than the 500 mg version. I thought I would try the latter [the 500mg] and although it is good, once it is done, I’m going to go back to the Lidke Tryptophan Complete. For me, it seems that the addition of the other ingredients really worked well for my body chemistry, leaving me feeling grounded, focused and well rested. 🙂

With the Tryptophan Complete she needed just 1 tablet (350mg) an hour before bed and with the Tryptophan 500 mg, she took 2 tabs (1000mg) an hour before bed.

My concerns right now would be individual reactions to any or all the other ingredients, since we all have very individualized needs. Someone did share this on one of my Facebook posts:

Can’t do the p5p! Makes me agitated.

I’m not yet sure what my final recommendations will be but these are my initial thoughts (which may be revised in the future):

  • I like to have my clients do a trial of the amino acids so they can find the ideal dose for their needs and right now I still feel this would still be the best approach to take – using 500mg tryptophan. Once you have figured out you do well with tryptophan-only product and have your dose, then consider reducing it slightly after about 2-3 weeks and adding in additional Tryptophan Complete.
  • The other option is this: if you don’t get the expected results with Tryptophan 500mg, then try the Tryptophan Complete. You may need the other ingredients for it to work well for you.
  • Don’t use the Tryptophan Complete if you know you react to any of the other ingredients
  • If you do better with higher doses of tryptophan don’t use more than the recommended 3x Tryptophan Complete because you’ll end up with too much of the other ingredients. Rather make up the difference with extra capsules of the 500mg Tryptophan

So for now, since I’m in learning mode/discovery mode I’d love your feedback.

I’d love to hear if you’ve used the Lidtke Tryptophan Complete product (personally or with clients/patients)? And what you’ve observed? Better or worse?

Have you also tried the Lidtke 500mg tryptophan in the past and noticed any difference when using the Lidtke Tryptophan Complete?

And how much of each did you find you needed?

So is it Tryptophan 500mg or Tryptophan Complete or a combination for you?

GABA, the calming amino acid: expert opinions

By Trudy Scott 69 Comments

gaba-opinions

GABA (gamma-aminobutyric acid) is one of my top nutrient recommendations for clients with physical tension, anxiety, overwhelm and panic attacks. I’m often asked if it really works and is it even worth taking so here is some feedback from practitioners from the Anxiety Summit, all of whom I consider experts on the topic.

Julia Ross, MFT, pioneer in the field of amino acid therapy, my mentor and the author of The Mood Cure and The Diet Cure shares this wisdom about GABA during our interview: Eliminating Anxiety: Amino Acid Therapy and Adrenal Balancing on season 1 of the Anxiety Summit:

Among other things, GABA relaxes the nerves in the muscles in the body. One of the most common kinds of feedback that we get from people who are doing a GABA trial is that it seems to take effect so quickly. This may be because, unlike tryptophan, which has to be converted into serotonin, GABA is the neurotransmitter and the amino acid all in one and requires no conversion.

There isn’t often a GABA discussion when the topic of the blood-brain-barrier doesn’t come up and whether GABA actually does work. Of course Julia addresses this too:

There is a myth going around, based on one old study, that GABA doesn’t cross into the brain, that it doesn’t cross the blood-brain barrier. But there are other studies that show that it does [here is a paper published earlier this year], and our clinical experience is overwhelming. This is the most popular trial that we do, the GABA trial, using only 100 mg. It zips right into the brain, and people immediately feel relaxed physically and mentally.

I see this with my clients on a daily basis and I can certainly attest to that personally too. I like to share that I was a “GABA girl”: when I had my terrible anxiety and panic attacks in my late 30s anxiety, GABA worked beautifully for me. It was amazing and life-changing! Zero anxiety and no more panic attacks!  

We are all individual and you may find that theanine works better for you than GABA. Julia talks about this too:

I would say about 15 to 20 percent of people who need this GABA-type relief of the tension and stress, don’t seem to get it from GABA. In those cases, most of them do get it from the amino acid, l-theanine, instead, in our experience.

Dr. Josh Friedman, is dear friend, colleague and integrative psychotherapist who uses amino acids and other nutritional approaches in his practice. I also had the honor of interviewing him on season 1 of the Anxiety Summit. I ask him if he uses GABA with his patients and what he thinks about the naysayers. I just love his answer:

[GABA] is definitely something I use. I am not a biochemist, so I actually don’t really know whether it crosses the blood/brain barrier, nor do I care actually. The first question should be, is it harmful? Are any of these things going to cause harm? And the answer with all the amino acids are no, they’re not going to cause harm, especially when compared to psychiatric medicines. The second question is, does it work? Is it helpful for our patients that we see in our practice?

GABA certainly worked for Meme Grant, GAPS Practitioner, Nutritional Therapist, FNTP, and fellow African. She had anxiety, panic attacks, didn’t enjoy speaking in public, had insomnia and was an emotional eater. I also interviewed her in season 1 and she shared this:

I took GABA for the first time in the afternoon and had no panic attacks that afternoon, and I took one in the evening and I did that for a couple of weeks, and I haven’t seen a panic attack since.

I find that many people do well with a combination of GABA and one or more of theanine, taurine and glycine. All of these are calming amino acids and since we are all unique you may find that one of these combinations work better for you.

Dr. Hyla Cass, M.D. board-certified in psychiatry and integrative medicine and the author of Natural Highs and The Addicted Brain and How to Break Free, talks about this in our interview: The Addicted Brain and How to Break Free   

If someone has anxiety, it’s not a Valium or a Xanax deficiency. It could be a GABA deficiency. And that could be due to stress. So if you’re low in GABA, there are some really cool things to take – theanine, glycine, taurine. The different nutrients work together and when we add them together, it’s more than the sum of its parts. So adding glycine and GABA together is going to give you a better result and you don’t have to use as much as each of the individual ones. So that’s nature’s Valium.

Jonathan Prousky, ND, MSc, editor of the Journal of Orthomolecular Medicine and author of Anxiety: Orthomolecular Diagnosis and Treatment shares this in our season 2 interview: Tapering off psychiatric drugs so they do not ruin your life

I have found GABA to be invariably helpful and I don’t really know exactly how GABA works but I know it to be very, very safe and, to me, that is fundamentally important. It’s not associated with any withdrawal, with any tolerance, with any habituation, so people can try it without a lot of concern.

Dr. Prousky uses both regular crystalline GABA and pharmaGABA but prefers the latter. He uses it as part of his SRR model for helping his patients taper of psychiatric drugs such as benzodiazepines. SRR stands for sedation, relaxation and regulation:

  • Sedation: one gets the sedating effects of GABA (he uses pharmaGABA at a dose of 100-200 mg)
  • Relaxation: niacin at a dose of 250-500 mg (immediate-release)
  • Regulation: melatonin (generally about 3mg) to helps regulate the sleep-and-wake cycles

GABA really does work if your anxiety is a result of low GABA levels. As Julia so wisely says:

On a scale of zero to ten, zero is not an unrealistic goal when it comes to anxiety.  It’s really the human potential and GABA [and tryptophan] give us access to it.

So we have many expert opinions but the best way to figure out if GABA works is to try it. You’ll know within 5 minutes if it’s working for you. This is one of the reasons I love the amino acids: you get results right away and it makes you feel less anxious right away, giving you hope while you deal with other factors that may be contributing to your anxiety.

How much GABA do we need and how do we take it? I find that GABA is most effective when taken sublingually. Source Naturals GABA Calm is a great sublingual that contains 125mg GABA, 50mg Glycine, 20mg taurine, some magnesium and 25mg N-Acetyl L-Tyrosine. I also really like Nutritional Fundamentals for Health GABA-T SAP which contains 300mg GABA 300 mg and 150mg theanine. This is pleasant-tasting when opened on to the tongue and seems to be most effective when held there for about 2 minutes.   GABA products that contain 500mg and 750mg are often too much for most of my clients.

You can find these and other GABA products that I recommend here

If you’d like to learn more about GABA from the above experts, you can get details of the Anxiety Summits here 

You’ll also learn about many other nutritional and biochemical causes of anxiety: gut health and the microbiome, hormone imbalance, methylation issues, other low neurotransmitter levels, pyroluria (causing social anxiety), oxalates/gluten (special diets), pyschoneuroendocrinology, heavy metals, poor liver health, adrenal issues like high cortisol, mold, candida, parasites and much more!

Have you used GABA or any of the other calming amino acids and found benefits? Please share what product and how much worked for you?

If you have not tried GABA, were you a naysayer but now feel more inclined to look into this?

Glutamine for healing a leaky gut

By Trudy Scott 46 Comments

glutamine-powder

Glutamine is one of my favorite nutrients for healing the gut (or repairing the intestinal barrier). Here is the extract from a paper published last month: Glutamine and intestinal barrier function:

The intestinal barrier integrity is essential for the absorption of nutrients and health in humans and animals. Dysfunction of the mucosal barrier is associated with increased gut permeability and development of multiple gastrointestinal diseases.

Recent studies highlighted a critical role for glutamine, which had been traditionally considered as a nutritionally non-essential amino acid, in activating the mammalian target of rapamycin cell signaling in enterocytes.

In addition, glutamine has been reported to enhance intestinal and whole-body growth, to promote enterocyte proliferation and survival, and to regulate intestinal barrier function in injury, infection, weaning stress, and other catabolic conditions. Mechanistically, these effects were mediated by maintaining the intracellular redox status and regulating expression of genes associated with various signaling pathways.

Furthermore, glutamine stimulates growth of the small intestinal mucosa in young animals and also enhances ion transport by the gut in neonates and adults. Growing evidence supports the notion that glutamine is a nutritionally essential amino acid for neonates and a conditionally essential amino acid for adults.

Thus, as a functional amino acid with multiple key physiological roles, glutamine holds great promise in protecting the gut from atrophy and injury under various stress conditions in mammals and other animals.

I’d like to share how some well-known practitioners use glutamine for healing.  

In this article by Dr. Josh Axe: 4 Steps to Heal Leaky Gut and Autoimmune Disease, glutamine is listed as one of the key gut healing nutrients:

L-Glutamine is critical for any program designed to heal leaky gut. Glutamine is an essential amino acid that is anti-inflammatory and necessary for the growth and repair of your intestinal lining. L-glutamine benefits include acting as a protector: coating your cell walls and acting as a repellent to irritants. Take 2–5 grams twice daily.

Be sure to check out the whole article for great images of leaky gut and how leaky gut can lead to leaky brain and mental health problems like anxiety, depression and bipolar disorders. What Dr. Axe states is so true: in many cases, if you can heal the gut, you can heal the brain.

Dr. Axe references a 2008 paper that discusses normalization of leaky gut in chronic fatigue syndrome with

natural anti-inflammatory and anti-oxidative substances (NAIOSs), such as glutamine, N-acetyl cysteine and zinc

Dr. Amy Myers, author of The Autoimmune Solution shares this in her blog called 8 Supplements to Heal a Leaky Gut:

L-Glutamine is an amino acid that is fundamental to the well-being of the digestive and immune systems. Glutamine is great for repairing damage to the gut, helping the gut lining to regrow and repair, undoing the damage caused by leaky gut, and reducing sugar cravings. I recommend 3-5 grams a day.

Dr. David Perlmutter, author Grain Brain shares this in his interview with Dr. Tom O’ Bryan on The Gluten Summit:

Adding in nutritional supplements like glutamine to allow the gut to calm down, heal itself, and begin to rebuild those vital intestinal barriers to keep out the invaders.

Dr. Mark Hyman shares this in his book The UltraMind Solution in the gut food section:

Glutamine: 2,500 mg twice a day [this equates to 5000mg or 5g/day] You can use the powder or capsule form. This is a nonessential amino acid that is the preferred fuel for the lining of the small intestine and can greatly facilitate healing. It can be taken for one to two months. It generally comes in powder form and is often combined with other compounds that facilitate gut repair.  

In an article on Leaky Gut Syndrome, Sharon Garrett shares how she loves a product called GI Revive, a product that combines glutamine with other gut-healing nutrients:

I LOVE this product and it lasts a long time. It contains L-glutamine, Slippery Elm, Marshmallow Root, Deglycyrrhizinated Licorice, Mucin, Okra Extract, Cat’s Claw, Quercetin, Prune Powder, Zinc, MSM, Chamomile, N-Acetyl Glucosamine, Aloe Vera Extract, and Citrus Pectin. This product was one of the cornerstones of my own progress to heal my gut, and I still use it today for maintenance!

You can read more about glutamine for blood sugar stability, calming and gut healing here.

And be sure to read cancer concerns and benefits if you have active cancer and talk to your doctor before using glutamine. Stay tuned for more blog posts on glutamine and the cancer debate.   I’m still gathering information to share with you.

Keep in mind that licorice root/DGL (deglycyrrhizinated licorice), probiotics, zinc, slippery elm, marshmallow root and quercetin are other supplement options for gut healing if you can’t tolerate glutamine for some reason.

Have you used glutamine for gut healing? Have you used other approaches for gut healing? Please share and feel free to post questions you may have.

Glutamine for blood sugar stability, calming and gut healing

By Trudy Scott 31 Comments

Glutamine powder by DFH: 3/4 of a teaspoon = 3g, so 1/6 of a teaspoon = 500mg
Glutamine powder by DFH: 3/4 of a teaspoon = 3g, so 1/6 of a teaspoon = 500mg

If you’ve been following me for awhile, worked with me, read my book The Antianxiety Food Solution, or listened in on The Anxiety Summit, you’ll be aware that I use glutamine with clients to help with blood sugar control while we’re figuring out diet/breakfast/adrenal health and the carbohydrate/sugar cravings associated with low blood sugar. Opened on to the tongue or taken in powder form glutamine is super-effective for stopping that intense desire for something sweet if it’s related to low blood sugar.

Integrative psychiatrist Dr. Hyla Cass and Julia Ross, MA both recommend glutamine for addiction and carb cravings, as well as for blood sugar control. During a past Anxiety Summit, Dr. Cass shared how to break free of addictions. And Julia Ross, a pioneer in the use of individual amino acids talked about glutamine and other amino acids for eliminating anxiety.

My clients also find benefits as far as healing the leaky gut and glutamine is recommended by many respected integrative practitioners for this purpose: Dr. Josh Axe, Dr. Amy Myers, author of The Autoimmune Solution , and Dr. David Perlmutter, author Grain Brain during his interview with Dr Tom O’ Bryan on The Gluten Summit.  Steven Wright also writes about leaky gut and glutamine on the SCD lifestyle blog, as does fermentationist Summer Bock.

With all these benefits, my clients love this amino acid!

Here is very encouraging feedback from one of the participants in the Amazing Aminos for Anxiety group program:

I started the glutamine trial low and slow. I have been taking 500mg three times a day AM AFT & BED for the past 4 days. I am celiac and have irritable bowel as well. The 2-3x a day diarrhea I have been experiencing has completely stopped! Blood sugar feels stable – not hungry and not craving. Psychologically, I’m feeling more resilient i.e., calmer and more positive on a daily basis. I am surprised that glutamine has helped so much 🙂  My gut is healing and my mental health has improved markedly through this trial.

She confirmed that adding the glutamine was the only change she made. She is already gluten-free and her diet doesn’t include any grains, legumes or lactose etc. She also avoids other foods to which she has had reactions.

I was so thrilled with these fabulous results and this was my feedback:

These are fabulous results – so happy for you! If you feel you could get added benefits i.e. if these symptoms (low blood sugar, hunger, craving, resilience) are not all 0s (with 10 being the worst on a scale of 1 to 10) then I’d consider bumping up the glutamine to 1000mg 3 x day to see if you get added benefits. If you don’t see added benefits then you can go back down.

It’s very common to get good results like this so I’d like to share another example. I met Nicole at the NTA conference and she shared how she suffers from low blood sugar issues:

I get irritable, I get shaky and I get to the point that if I don’t get food NOW I think I’m going to hurt something!

She did a trial of 500mg glutamine and in under 5 minutes she went from that frantic feeling to a very calm feeling:

I’m ok. I feel happy, I feel calm, I feel I can make it longer without needing food right away. I’m impressed at how well that worked for me.

You can read more about low blood sugar and watch Nicole’s video feedback here.

Of course there is research supporting the many benefits that glutamine has for gut health. Here are some excerpts from the abstract of a 2015 paper titled: Glutamine and intestinal barrier function.

glutamine has been reported to enhance intestinal and whole-body growth, to promote enterocyte proliferation and survival, and to regulate intestinal barrier function in injury, infection, weaning stress, and other catabolic conditions

glutamine stimulates growth of the small intestinal mucosa in young animals and also enhances ion transport by the gut in neonates and adults

as a functional amino acid with multiple key physiological roles, glutamine holds great promise in protecting the gut from atrophy and injury under various stress conditions in mammals and other animals.

And this 2015 paper titled: Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults found that adults supplemented with 30g of glutamine a day for just 14 days had a change in gut bacteria:

Oral supplementation with [glutamine], for a short time, altered the composition of the gut microbiota in overweight and obese humans reducing the Firmicutes to Bacteroidetes ratio, which resembled weight loss programs already seen in the literature.

In a randomized, double-blind, placebo-controlled trial that was conducted in children aged two months to nine years from the urban shanty compound community of Fortaleza, Brazil, it was found that:

Glutamine and all combined nutrients (glutamine, vitamin A, and zinc) improved the intestinal barrier function in these children

When it comes to cravings, addiction and appetite we have this research supporting the use of glutamine:

I do want to end by saying there are some possible concerns with cancer supplementation and be sure to check with your oncologist if you are currently undergoing treatment. I write about these concerns here – Glutamine supplementation: cancer concerns and benefits.

Have you successfully used glutamine for helping with low blood sugar control, reducing carb or other cravings/addictions, and healing your leaky gut?

 

Tryptophan and 5-HTP combination for anxiety and sleep: when to use

By Trudy Scott 22 Comments

amazing aminos for anxiety

Here is a great question that came in from one of the attendees of the live Amazing Aminos for Anxiety program that I hosted earlier this year.   This attendee is asking when to use a combination of tryptophan and 5-HTP for anxiety and sleep, and concerns about high cortisol when wanting to use 5-HTP:

The book says “for symptoms that occur earlier in the day, 50-150 mg of 5-HTP on waking and midmorning” but it also cautions about taking 5-HTP if one has severe insomnia (which I do) as it can raise cortisol. Is it okay to take tryptophan upon waking and mid-morning? I’m assuming the reason for holding off until late afternoon is to avoid daytime drowsiness, but am wondering if this is where the tyrosine may come in? (At the end of the program)

I started getting good results at 500 mg tryptophan. Sometimes I needed more so I doubled the dose to 1000 mg. Sometimes I got better results than others. It’s possible I may need to take more than that – the book says to take up to 1500 mg. Is consistency key (as opposed to PRN/as needed) when taking tryptophan, in the same way that one has to build up a blood level of serotonin when taking an SSRI? I also wanted to mention that prior to coming off my SSRI, my mood was fine

She is referring to my book The Antianxiety Food Solution and she had been taking these amino acids before starting the group program with me. Her goals were to address her insomnia, the anxiety and the depression. The tryptophan she had been taking was not the Lidtke tryptophan, which is the brand I recommend.

You can listen to the 4 minute snippet of this question and my answer here:

 

Before using any amino acids be sure to check the Amino Acid Precautions and work with your doctor if needed.

And a friendly reminder for you …. we are offering $100 off each of the 3 options of The Amazing Aminos for Anxiety homestudy programs. This offer expires today, Monday October 19th at 9pm PST midnight EST  (previous emails said 9pm EST – sorry about that)

This is a powerful home study program that results in you feeling

  • less stressed and overwhelmed, and happier
  • more energetic and focused
  • sleeping through the night
  • and no longer suffering from emotional eating/stress eating!

I walk you through, one week at a time, how to use five of the top individual amino acid supplements (tryptophan/5-HTP, GABA, glutamine, DPA/Endorphigen and tyrosine) to help you eliminate anxiety, social anxiety and panic attacks. We also cover pyroluria, other key nutrients, diet and lifestyle changes.

There are 3 program options available:

  1. Basic: Homestudy if you’re a DIY person

     OR

  1. Plus: Homestudy + 2 Q and A Live with Trudy (if you need some guidance and will have questions you can opt for this one)

     OR

  1. Premium: Homestudy + 4 Q and A live with Trudy (if you need some guidance and will have questions) + private Facebook group for group discussions and interactions.

All 3 options include access to Questions and Answers from the previous program so you get to learn from others. Options 2 and 3 include the LIVE Question and Answer sessions i.e. you can ask your own questions (option 3 also includes the facebook support).

For #3 Premium program, we will also be closing the cart and not taking new registrations until January next year

You can check out the 3 program options and register here https://www.everywomanover29.com/aminosforanxietyhs/

Got questions about the program or tryptophan and 5-HTP? Feel free to ask them below and read some of the commonly asked questions on this blog post