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My Kid is Not Crazy and PANS/PANDAS awareness day 2017

By Trudy Scott 33 Comments

Earlier this week was PANS/PANDAS awareness day 2017 so I’d like to bring some awareness to this condition that causes sudden-onset OCD (obsessive compulsive disorder) type symptoms and anxiety. The PANDAS Network defines PANDAS as follows:

PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) occurs when strep triggers a misdirected immune response results in inflammation on a child’s brain. In turn, the child quickly begins to exhibit life changing symptoms such as OCD, anxiety, tics, personality changes, decline in math and handwriting abilities, sensory sensitivities, restrictive eating, and more.

PANDAS Network estimates that PANDAS/PANS affects as many as 1 in 200 children.

This Huffington Post article: Misdiagnosed: How Children With Treatable Medical Issues Are Mistakenly Labeled as Mentally Ill covers one family’s experience with misdiagnosis with their daughter and the treatment that eventually helped her recover. As you’ll read in the blog, PANS/PANDAS is still very poorly understood in the medical community and misdiagnoses are very common:

the vast majority of pediatricians, child psychiatrists, and neurologists are unapprised of the latest research and continue to misdiagnose children who have PANS/PANDAS with any number of mental health disorders.

The new movie My Kid Is Not Crazy is another great resource for gaining a better understanding of this condition. Here are some snippets from this excellent movie:

Nine-year-old Kathryn was a normal, healthy child. She was a star student, athlete and dancer. In a matter of days, she would become totally dysfunctional. Kathryn had alarming rapid-onset OCD refusing to eat or drink. She had tremendous separation anxiety and would become panicked if her parents were not in sight. She had trouble sleeping and showed signs of age regression in vocabulary and handwriting.

How did this happen?

Kathryn’s family and many families like them— turned to a fractured medical system, where there is fierce disagreement about how to help their daughter. More often than not, a child with these symptoms would be diagnosed as having mental illness. They’d be treated with anti-psychotic medication, behavior therapy, and even hospitalization.

But more than 30 years ago, Susan Swedo—a doctor with the National Institutes of Health—discovered that an undiagnosed strep infection was the cause of one child’s disabling illness. The more Swedo dug, the more evidence she found: Strep was linked to symptoms normally chalked up to psychiatric illness.

She also discovered how non-accepting modern medicine can be of new ideas.

Swedo has put her reputation and career in jeopardy as she fights to cure the condition she named: Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS). Neurologists Jonathan Mink, Roger Kurlan, Harvey Singer and others publically ridicule Swedo and her PANDAS theory, creating controversy over diagnoses and treatment. This group has become known on social media as the “non-believers.” The result: the entire pediatric-care industry is confused and doesn’t know what to do.

And it’s the children who suffer.

“My Kid is Not Crazy,” a film by Tim Sorel, tracks the journey of six children and their families as they become tangled in the nightmare of a medical system heavily influenced by the pharmaceutical industry. Here it’s common for a caregiver to prescribe a young child with a Selective Serotonin Uptake Inhibitor (SSRI) but hesitate to prescribe an antibiotic to counteract a potential infectious-based trigger. For some of these kids, what happens after several years is shocking and sad.

You can watch the trailer here and rent the movie to watch it online or purchase the DVD here.

The movie site also lists many helpful resources for PANS/PANDAS.

Last week’s blog: Anxiety, compulsive thinking, counting behaviors: gluten, tryptophan and inositol covered gluten, tryptophan and inositol for OCD symptoms. I mentioned that I also always keep Lyme disease, heavy metals and PANDAS on the list as possible areas to refer out for if symptoms are not resolving with the above nutritional approaches, so it made sense to share more about PANDAS this week.

Even if the OCD and anxiety is due to PANS/PANDAS, I would still encourage a gluten-free diet and trials of tryptophan, GABA and inositol (and other nutritional approaches) in order to provide some relief while the infection/s are being addressed. Similar results are seen when providing nutrient support like the use of GABA (and/or tryptophan) for relief for Lyme anxiety.

Do you know about PANS/PANDAS and the connection to OCD and anxiety?

Have you seen symptom resolution by addressing the infection/s one of your children, personally or with a patient or client?

Have you seen some symptom relief when also using GABA and/or tryptophan and/or inositol?

Anxiety, compulsive thinking, counting behaviors: gluten, tryptophan and inositol

By Trudy Scott 42 Comments

Today I’m going to share my feedback on a question I received on how to approach working with a child with anxiety, compulsive thinking and counting behaviors in the hope it can help you or someone you know (or are working with if you’re a practitioner). Here is the question:

Regarding anxiety and compulsive thinking/OCD counting behaviors in a 12 year old, have you experienced (or heard through client sharing) a correlation with certain foods or inflammatory compounds? In a younger person, I am trying figure out the triggers if there is low production of certain neurotransmitters driving the symptoms. This child in particular has had a long history of allergies and terrible asthma (requiring nebulizer treatments) so I’ve long suspected food sensitivities as a driver for systemic inflammation but am trying to connect the dots for her parent. The counting seems to be a distraction of sorts for her – I assume following a triggering thought. This parent is very new to integrative therapies so treating with an amino acid is going to *feel* like she’s not doing enough as parent. Standard talk therapy has not helped.

This is how I responded and it’s how I would start to work with a parent with a child with these types of issues.

After looking at the basics to make sure the child is eating real whole food with no additives, is not consuming any caffeine and is getting quality animal protein at breakfast (to keep blood sugar stable and reduce anxiety), I always consider gluten and even dairy and other food intolerances. I write about the success of a gluten-free diet with a 7 year old boy in this blog: Integrative Medicine Approach to Pediatric Obsessive-Compulsive Disorder and Anxiety. He saw a “marked reduction of OCD symptoms and anxiety along with marked improvement of social behavior and school work.”

OCD and counting behaviors are classic low serotonin symptoms and her anxiety could be the low-serotonin worrying type or the low GABA type which is more physical anxiety. I’d have them do the amino acid questionnaire

I’d start with a trial of tryptophan – using 100mg of Lidtke Chewable Tryptophan – to help with the OCD, counting and worry-type anxiety. If it helps, I’d have her use it twice a day mid-afternoon and evening, increasing it over the course of a few weeks to find the ideal amount for symptom relief (and keeping a food mood log to record doses and symptoms).

Some people do really well with tryptophan, others do better with 5-HTP for low serotonin symptoms, so doing a trial with 25mg of 5-HTP would be an option if the tryptophan doesn’t help as expected.  

I would carefully review the precautions with the mom as tryptophan and 5-HTP can sometimes be an issue with asthma and may need to be lowered or discontinued.

Inositol can be added if additional nutritional support is needed for the OCD and counting behaviors and may even be needed to replace the tryptophan or 5-HTP if either one triggers asthma. The maximum dose in the research is 18g of inositol per day and I start at 2g once a day and increase slowly over a few weeks to find the ideal dose. Here is feedback from one mom on how inositol alone helped her son with migraines, stress, anxiety and OCD

Once we’ve figured out nutritional support for the low serotonin symptoms then we’d address low GABA if needed, using sublingual GABA. [Update Nov 17, 2017: I mentioned GABA as a possibility but with her symptoms and the new GABA research on intrusive thoughts, a GABA trial would definitely be something to pursue]

I found this comment to be rather unusual: “treating with an amino acid is going to *feel* like she’s not doing enough as parent.” The parents I work with are thrilled to discover how powerful the amino acids are and how quickly they provide amazing results.

These other factors would also be addressed: possible high cortisol, gut health and any of the other possible contributing root causes. I also always keep Lyme disease, heavy metals and PANDAS on the list as possible areas to refer out for if symptoms are not resolving with the above approaches.

Here are links to the amino acid questionnaire, the precautions and the supplements:

  • I have my clients complete the Amino Acids Mood Questionnaire from The Antianxiety Food Solution and check off their symptoms in each of the sections. The rating uses scale of 1-10 with 10 being worst.
  • I also have my clients review the Amino Acids Precautions and we figure out which amino acids they can and can’t use
  • These are some of the supplements I use with my clients

Have you used any of the above approaches with your child or for your symptoms or for a client/patient?

Collagen and gelatin lower serotonin: does this increase your anxiety and depression?

By Trudy Scott 471 Comments

I see everyone raving about gelatin and collagen – and rightly so – they have amazing health benefits. However, no-one is addressing the fact that gelatin is actually used in tryptophan-depletion studies to lower serotonin (gelatin is derived from collagen: when collagen breaks down, it becomes gelatin). When I first discovered this fact it really concerned me that this very important aspect is ignored so I added it to my long list of topics to investigate.

I posted the above on Facebook last month as part of a fact-finding exercise and appreciate all the feedback and questions. Today I share some of the feedback and research and I’d love to hear from you what your experiences have been.

I share how my experience with collagen left me flat and worried until I added tryptophan; feedback from individuals who wondered if collagen was affecting their sleep, making them moody, on edge or feeling night-time anxiety; some reported no mood issues when using collagen with tryptophan; feedback from many who didn’t notice any obvious mood issues at all ;and one woman who uses collagen ‘therapeutically’ to lower her serotonin levels.

I also share some very interesting research on why some people seem to be adversely impacted by acute tryptophan depletion/ATD (caused by collagen or gelatin consumption) while others are not. There are definitely some folks who are more susceptible.

The health benefits of collagen

In case you’re new to collagen, Dr. Josh Axe provides an excellent overview of the health benefits of collagen

  1. Improves Health of Skin and Hair
  2. Reduces Joint Pains and Degeneration
  3. Helps Heal Leaky Gut
  4. Boosts Metabolism, Muscle Mass and Energy Output
  5. Strengthens Nails, Hair and Teeth
  6. Improves Liver Health
  7. Protects Cardiovascular Health

Gelatin is used in tryptophan depletion studies

Tryptophan-depletion studies have been done for years, as a way to study the relationship between low serotonin and depression.  Often a tryptophan-deficient amino acid mixture is used for this purpose.  More recently, collagen and gelatin are being used.

Collagen and gelatin are an excellent source of these amino acids: proline, glycine, glutamine and arginine, but they do not contain the amino acid tryptophan.

This paper, Pharmacokinetics of acute tryptophan depletion using a gelatin-based protein in male and female Wistar rats summarizes what we find in a number of studies that use gelatin for the purpose of lowering serotonin levels, in order to study the relationship between serotonin and behavior:

The essential amino acid tryptophan is the precursor of the neurotransmitter serotonin. By depleting the body of tryptophan, brain tryptophan and serotonin levels are temporarily reduced. In this paper, several experiments are described in which dose and treatment effects of acute tryptophan depletion (ATD) using a gelatin-based protein-carbohydrate mixture were studied in male and female Wistar rats.

My experience with collagen – flat and worried until I added tryptophan

When I recently injured my back and sprained my ankle, I decided to add collagen to speed up the healing and very quickly had to take a deeper dive into the topic because I noticed it affected my mood right away! I was using just one big scoop of collagen in a protein shake (pea protein) and yet I felt flat and slightly anxious within a day. It was the worried low-serotonin kind of anxiety in the early hours – something I haven’t felt in quite some time.

I wondered if it was due to the injury and inflammation my body was dealing with or if it was related to the effects of tryptophan depletion. I stopped the collagen and then added it back and had the same experience. I did this a few times and experienced similar feelings each time.

When I used tryptophan mid-afternoon and at bedtime I felt fine and was able to continue taking the collagen with no problems. I am prone to low serotonin – it was one of the root causes of my big anxiety issues in my late 30s – so I may be more affected than the average person.

Wondering if collagen causing mood issues and an increase in anxiety?

Here is feedback from someone who is wondering if collagen is causing her mood to dive:

I have wondered if it affects my mood so I haven’t been using it lately. Interested to see what other people say. I was using about a table spoon in a drink that I would sip on throughout the morning. My moods just take dives now and then. I have isolated gluten as a HUGE factor. I am forever wondering what else causes the dives and I began to wonder if collagen was causing problems so I haven’t used it in several months.

Stephanie feels moody when using collagen:

I have found that the days I take collagen that I’m moody. I’ve kept trying, but am always surprised by the reaction. I even mentioned it to my naturopath recently. Curious to see if there’s a connection.

Here is feedback from someone also reporting mood dives and feeling on edge (although as I pointed out to her the feeling on edge is very likely due to or partly due to the coffee):

I take collagen (grass-fed and grass-finished) in my coffee every morning. I’ve also had some mood dives consistently the last few months and feel more on edge. I’ve honestly never made the connection and actually thought it was hormones. Something to think about!

Melissa shared it affected her sleep:

As soon as I started taking gelatin daily I have had difficult falling asleep.

Katinka began having strange night time anxiety:

I did [Vital Proteins grass fed beef gelatin] for 2 weeks in bone broth. My nails grew like crazy, but at the same time I begun having strange night time anxiety: worry, obsessive, but not any of the other symptoms like depression and cravings. It is interesting to me because this was the only time I had anxiety at night since going gluten free.

Collagen caused a racing heart for Beverly:

Used to take Vital Proteins products. Was woken up several times in the night with racing heartbeat and out of breath. This went away when I stopped the collagen. I have symptoms of low serotonin but have not tried tryptophan

No noticeable problems

Many people shared that they didn’t notice any obvious mood issues so it’s clearly not a problem for everyone:

  • Jaime: Interesting, I use it almost daily for protein at breakfast. I will pay attention better. No obvious problems now (used for 9 months).
  • Angela: …I don’t think I have any side effects and I do have serotonin issues. I think I will have to do more research
  • Courtney: I just started using collagen peptides but not every day. Maybe once or twice a week. I haven’t noticed any difference in mood but I also just started taking it a few weeks ago.
  • Debra: I take 1bsp of Great Lakes Collagen Hydrosylate every day and take it to help heal my leaky gut….haven’t noticed any particular side-effects. I alternate it with the normal gelatin. I suffer from complex PTSD, anxiety and depression…I haven’t noticed any difference in that either

Jessica Drummond, nutritionist and physical therapist, and an expert on female pelvic pain and women’s health shared:

I use collagen regularly and I also eat quite a lot of meat and fish. For me both help me to feel very grounded and less anxious. I think of collagen as balancing for all of the muscle meat that we eat. I eat anywhere from 10-20 grams 4-5 days per week.

 

Feels anxious using gelatin, stop using it and anxiety is gone/less

Laura’s anxiety got worse within a few months of adding daily gelatin:

Wow, I never heard that gelatin can lower serotonin. I started using [Puritan’s Pride brand], 650mg, daily about 6 months ago to strengthen my nails. It’s worked very well for that. About a couple months ago my anxiety started to get worse again. My anxiety shows up as fear and worry mostly and not being able to quiet my mind. I had gotten it under control for almost 2 years now. I wonder if there is a connection. I’m going to stop taking the gelatin and see if my anxiety improves. I have not tried tryptophan, but I have found GABA helped quiet my mind and let me sleep better.

She decided to stop taking it to see if her anxiety symptoms would reduce and when I checked back with her she shared this:

I was surprised to find after about 2 weeks of stopping the gelatin, I began to feel more calm again and it’s been a lasting change. I still take zinc, vitamin b6 and lysine in the morning and GABA in the evening. This combination works well for me. I’m so grateful for all the information you share! Thank you!

Toni experienced something similar:

I’ve been using Organic collagen for about 8 months now… love the hair and skin results. My tummy felt better at first but not currently. My anxiety and panic attacks are off the charts: panic attacks, heart racing, sweating, brain fog. I want to escape -like fight or flight. Definately obsessing and fears. Memory difficulty. I have an upcoming GI appointment to check for Candida /SIBO… but I had no idea this could add to my anxiety. I’ll be looking forward to more information, Seriously.

And a few weeks after stopping the collagen she shared this:

I stopped using the collagen. Since then, my anxiety and panic are decreased by less than half. Mild in comparison. I’m definately taking a long break.

Keep in mind I’m not suggesting we should not be using collagen – just that if it seems to lower serotonin and increase anxiety/depression doing a trial with tryptophan may be the solution (more on that and some other possible causes of anxiety below).

When used with tryptophan – no mood issues

Karen uses collagen and tryptophan at night:

I use collagen every day. But hey, I also take L-tryptophan every night for anxiety. It runs in the family and a small amount of Tyrptophan at night helps resolve mine. No clue there was a connection

Maxine uses it every morning and takes 1 tryptophan before bed and reports no mood issues

I take it [Great Lakes gelatin and Vital Choice collagen] every morning in my tea and at night in my bone broth for my skin and joints and I take one tryptophan before bed. The tryptophan with GABA before bed is for better sleep. No mood issues.

 

Used ‘therapeutically’ to lower serotonin

Misty reports using it ‘therapeutically’ to lower her high serotonin levels. This application is new to me and I find it quite fascinating:

I use it to reduce tryptophan because I have a tendency toward high serotonin. I have suffered my entire life with ADD, tics as a child, grinding teeth, general anxiety, lack of motivation and later, IBS. In my quest to maximize my health, I finally came to these web pages for help. In my 53 years I’ve never been as calm as I am now. If I’m not careful, I can get a bout of IBS (not food related and trust me, from GAPS to AIP, nothing really affects me). I reduce tryptophan and I’m balanced. It seems contrary but it works for me and so many others

She links to these articles Tryptophan, Sleep, and Depression and The Sadder Side of Serotonin which both refer to the work of Ray Peat who I recently discovered is very much against the use of tryptophan.

I agree with the premise of too much serotonin causing issues (often the same symptoms we see with serotonin that is too low) but not the general message that tryptophan supplements and foods high in tryptophan are harmful and should be avoided by everyone. Based on the clinical results myself and other practitioners see boosting low serotonin with tryptophan and/or 5-HTP -and the wonderful results they experience – in my opinion, this is really all about biochemical individuality.

I decided to share this story here, even with the controversial tryptophan articles, because it illustrates that it is highly likely that the collagen is lowering her serotonin levels and making her feel better. I’ll tackle the above negative articles about serotonin and tryptophan in a separate blog post.

Why are some people adversely impacted by acute tryptophan depletion/ATD while others are not?

UPDATE: Dec 22, 2017. This section adds additional evidence or possibly some theories for why some people are adversely impacted when consuming collagen, while others are not impacted mood-wise – all related to the lowering of serotonin levels. These are called ATD or acute tryptophan depletion studies.

This paper: The effect of raising and lowering tryptophan levels on human mood and social behavior explains that effects of ATD can vary based on susceptibility of the study participants to clinical depression:

Acute tryptophan depletion (ATD) studies indicate that low serotonin can lower mood and also increase aggression, although results vary somewhat between studies with similar participants. Lowering of mood after ATD is related to the susceptibility of the study participants to clinical depression, and some participants show no effect on mood.

In healthy individuals, there is little or no lowering of mood, although results can be quite variable between studies, with some lowering of mood seen more often in women than in men.

The author reports the following variable responses:

In healthy participants with a family history of depression, there is a lowering of mood although mood remains within the normal range of mood.

In newly recovered depressed patients on antidepressants that act on the serotonergic system, 50 per cent or more of the patients show a temporary reappearance of the depressed mood they experienced before recovery.

In recovered depressed patients off antidepressants, only a small percentage of the patients show a marked lowering of mood.

In recovered depressed on noradrenergic antidepressants, there is no lowering of mood.

The results of the ATD studies suggest that lowering serotonin synthesis can lower mood in some circumstances, and that the magnitude of the effect tends to be greater in people with a greater susceptibility for depression.

Other studies report on these groups of people that were adversely affected with a lowered mood after ATD:

OCD / obsessive compulsive disorder: Patients with OCD experienced a decrease in control and an increase in interfering thoughts after acute tryptophan depletion. There was no effect on anxiety in this group.

Genetic polymorphisms: A number of papers show some genetic polymorphisms make some individuals vulnerable to increased depression after acute tryptophan depletion, such as MAOA and 5-HTTLPR (the serotonin transporter gene). In one 5-HTTLPR polymorphism study differences were seen between men and women: healthy men became more impulsive, whereas healthy women showed a mood reduction after ATD. Keep in mind that having a polymorphism doesn’t mean there will always be an issue, instead, it means there may be a predisposition.

Smokers: The moderating influence of nicotine and smoking on resting-state mood and EEG changes in remitted depressed patients during tryptophan depletion.

Comorbidity between depression and tobacco use may reflect self-medication of serotonergically mediated mood dysregulation [and acute tryptophan depletion or ATD] increased self-ratings of depressed mood [in certain smokers].

Although this study was looking at the role of nicotinic receptors in disordered mood and the self-medication of mood by smoking, we may be able to extrapolate this for our purposes because it was this one subset of smokers who were more depressed after tryptophan depletion. Could it be that smokers or even former smokers are more likely see increased depression after consuming collagen because it contains no tryptophan? Or is it that smokers tend to be drawn to smoking because they are prone to low serotonin?

Women ecstasy users: The effect of acute tryptophan depletion on mood and impulsivity in polydrug ecstasy users.

Women polydrug ecstasy users appear to be more susceptible than men to the effects of lowered serotonin levels [when they] received a tryptophan-deficient amino acid mixture and a control amino acid mixture containing tryptophan, at least 1 week apart.

The women who were impacted – with a lowering of their mood – used a tryptophan-deficient amino acid mixture and not collagen. The authors suggest this could be due to the drug-use causing progressive damage of serotonin neurons. Could this also happen with collagen consumption in current and possibly prior drug users? What about users of other street drugs or even medications that may also damage serotonin neurons?

Interestingly, in a study looking at five chronic fatigue/CFS patients, none of them showed any significant differences in fatigue, depression and concentration when subjected to acute tryptophan depletion /ATD. Was this group of patients too small or were none of them susceptible to low serotonin?

This is just a small selection of studies looking at the effects of acute tryptophan depletion or ATD but they give us much to think about when it comes to considering the varied effects we are seeing when individuals consume collagen.

If collagen affects you adversely and makes you feel more depressed, more anxious and experience worse sleep, can you relate to any of the above scenarios?

More questions and looking for your feedback

As you can see we have very different experiences but there are enough unanswered questions we need to be asking:

  • Are the negative effects because of low serotonin? If yes, are some of us more susceptible to the serotonin-lowering effects than others and should we stop using collagen despite all the health benefits?
  • And should we be assessing for low serotonin levels before using collagen or gelatin, and supplementing with tryptophan when it is low (more on this below)? There is one company that has added tryptophan to their collagen – is this a good idea?
  • Or are the negative effects some people experience due to glutamates, arginine, histamine, because of quality issues and glyphosate levels, an increase in oxalates or something else such as not eating enough animal protein?

I’ll address the above questions and share some additional research and feedback from collagen experts in part 2 of this article.

Until then, if you have observed a mood dip or increase in anxiety since using collagen or gelatin, I would suggest you stop using collagen/gelatin and see how you feel, then add it back and see how you feel. If you do see a correlation, do the low serotonin questionnaire and a trial of tryptophan (after checking the precautions) to see if this improves your mood when using collagen/gelatin. I recently blogged about tryptophan here (brand is important).

Resources if you are new to using the amino acids as supplements

If you are new to using any of the amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the symptoms of neurotransmitter imbalances, including low endorphins).

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, self-medicating with alcohol and more.

The book doesn’t include product names (per the publisher’s request) so as mentioned above, this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

As mentioned above, Lidtke Endorphigen is the DPA product I’ve had the most success with (and it can be found in my online store). Doctor’s Best D-phenylalanine is also a good product.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA Quickstart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support. There are many moms in the program who are having much success with their kids.

You can then use this knowledge to then trial DPA and other amino acids or move on to the Amazing Aminos for Anxiety Program and get help there.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids with success with their clients/patients.

 

I would love your feedback. Do you use gelatin or collagen regularly i.e. daily or weekly? And why do you use it? How do you use it and what benefits do you notice?

Have you noticed any worsening of mood or an increase in anxiety or any of the other low serotonin symptoms? Do you take tryptophan to offset the fact that gelatin or collagen doesn’t contain any tryptophan?

Have you done the off/on test with collagen/gelatin and what was the outcome?

I’d love your feedback in the comments. Be sure to share what you’re using (collagen or gelatin and the brand), how much, how often you consume it, what you take it with, how much caffeine you consume, how much protein you consume on a daily basis and what kind of protein, and how you react to home made bone broth. If you’re comfortable with sharing how you score on the low serotonin questionnaire (now or in the past i.e. are you prone to low serotonin) and if you’re using a SSRI (or have in the recent past), this may help us piece the puzzle together.

Tyrosine for focus, motivation, energy, a good mood and possibly even anxiety

By Trudy Scott 42 Comments

Today I’m reviewing tyrosine, the amino acid that boosts catecholamines and helps with focus, motivation, energy (especially when you crave carbs for energy) and the blah kind of depression. It’s wonderful for helping you easily quit coffee/caffeine (when you are using it to “self-medicate” due to low catecholamines). It also provides support for the thyroid and surprising as it sounds, it may even ease some types of anxiety.

I’m also sharing some additional resources for you on tyrosine.

Tyrosine helps with energy, gives someone else migraines – look at precautions

Here is some feedback from my recent facebook post about tyrosine

  • Lorraine shared:

It really helped me have energy and endurance to be able to work out again! I went from not being able to even handle 20 minutes of weight lifting to doing regular 30 minute sessions and feeling energised and strong instead of depleted and exhausted.

  • Fay shared that it gives her a migraine. Migraines are one of contraindications with tyrosine if you are prone to them or have a history of migraines (and Fay does a history). This doesn’t mean you can’t ever benefit from tyrosine. With clients with migraine history we just start low, having them open a 500mg capsule and use just 50-100mg to start and then increase if they can.
  • Aaron Mello, Master Nutrition Therapist and founder of MoodFood Clinic, a practice that focuses on men’s mental health, loves using tyrosine with his clients and prefers it over phenylalanine because of the PKU contraindication. I agree and prefer tyrosine although I’ve only ever had one client with PKU. Aaron also mentioned that he also likes a combination product like Designs for Health DopaBoost: “I like that it has P5P and the mucuna is a natural source of L-dopa in addition to the tyrosine.” I do prefer standalone amino acids to start with (so just using tyrosine alone) but do also like the combinations in DopaBoost.

With all the amino acids, it’s important to be aware of the precautions. I mentioned PKU above. Here are other situations when tyrosine cannot be used: melanoma and Grave’s disease/overactive thyroid.

As with migraines, tyrosine does need to be watched with high blood pressure and bipolar disorder i.e. it may be tolerated and may not be tolerated. A trial will help you figure this out.

I personally can’t use either mucuna or tyrosine in large quantities but can tolerate the small amount in the Source Naturals GABA Calm product. The same tyrosine precautions do need to be considered when using GABA Calm for the low GABA type of anxiety.

Focus issues and ADHD – tyrosine or GABA?

Anxiety can often show up as focus issues or ADHD, especially in children who may not be able to articulate that they are anxious. Jenny is a mom in my facebook community and a friend of hers recommended GABA for her daughter after reading some of my posts. She shared this wonderful feedback:

My daughter hasn’t been diagnosed with ADHD but has a lot of ADHD qualities. We were having a huge amount of behavior problems as she is getting older (she’s 11). I did some research and went to the health food store and bought a bottle [of GABA Calm]. At this point I was mentally exhausted from all the fighting and drama at home and at school. I was desperate and didn’t want to put her on any hard medication.

She has had amazing behavior at school and at home since giving it to her. She’s almost like different child. GABA has truly changed our life. She’s been taking it for almost 2 months.

Anxiety and ADHD – where to start?

I recently received a great question from someone who heard my interview on the migraine summit:

I have a whole lot of overlap here. I’ve been diagnosed with ADHD with have anxiety issues. I also have a gluten sensitivity and migraines. Luckily, since I meditate daily, my migraines only occur every other month or so but usually involve weather changes.

It’s not uncommon to have overlaps and often addressing a few factors helps all issues. It sounds like she is gluten-free which is one common underlying factor in ADHD, migraines and anxiety. If someone is coming to see me for their anxiety we’ll work on that first – using GABA or tryptophan first – because tyrosine can help with ADHD but can make someone more anxious. We calm them first and then look at improving focus issues. With ADHD and anxiety, I also consider low blood sugar and making sure animal protein is being consumed at breakfast, and also check for low zinc and low iron (for starters).

GABA didn’t help her anxiety but tyrosine did

Everyone is different so using the trial method is the best way to figure out what you need. One of my past clients who had terrible anxiety, trialed both GABA and tryptophan and while she did get some benefits with both it just wasn’t enough.

She was sleeping better but still felt so stressed and anxious when preparing for an important meeting at work. The anxiety also seemed to get worse during the meeting which she was in charge of running. She did score high on the low catecholamines section on the amino acid questionnaire but were working on the anxiety before addressing poor focus and low motivation. It turned out that her anxiety escalated around her work meetings because of her lack of focus and low motivation – she was pushing herself to get through them. Once she added tyrosine her anxiety was under control. In this instance tyrosine actually helped ease the anxiety because he ADHD and motivation and drive improved!

Using tyrosine

Here is one tyrosine product I use (there are many others on the market)

Progressive Labs tyrosine 500mg: 500mg l-tyrosine.  As I mentioned this is the last amino acid I trial with my anxious clients because it can make you more anxious (although as I mentioned above, with one client, it reduced her anxiety because she was able to focus better at work).

As with all the amino acids, when using tyrosine:

  • Start low (500mg is a typical starting dose) and increase as needed.
  • Do a trial to determine if the ADHD, fatigue, depression, low motivation is due to low catecholamines. I always do this with clients before starting any amino acid. Be sure to read how to do an amino acid trial. It has the amino acid questionnaire, the precautions and information on how to use targeted individual amino acids.
  • Take between meals and away from protein for the best effects

Tyrosine should never be used after 3pm as it’s too stimulating when used after this time. For my clients with sleep issues we go slow and stop after the mid-morning dose until we determine if sleep is being affected.

This blog post is part of the series of amino acid product reviews:

The resources in this blog and my other articles are intended to be used in conjunction with my book: The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings. If you do not have my book I highly recommend getting it and reading it before jumping in and taking the amino acid supplements.

There is a complete chapter on the amino acids and one for pyroluria, plus information on real whole food, sugar and blood sugar, gluten, digestion and much more.

You can find the tyrosine product I recommend on this blog: The Antianxiety Food Solution Amino Acid and Pyroluria Supplements

 

For today’s tyrosine review:

  • What about your success stories with tyrosine? how has it helped you?
  • Or has it been an issue for you?
  • As I mentioned above it’s the last amino acid I used with my anxious clients because it can make you more anxious but it may just help your anxiety

If you have questions or feedback please post them below or on the supplements blog

How to Beat Anxiety and Resolve Panic Attacks with Targeted Amino Acids: Wellness Mama podcast

By Trudy Scott 20 Comments

Today I share my wonderful interview with Katie, the “Wellness Mama”. We talk about my favorite topic: How to Beat Anxiety and Resolve Panic Attacks with Targeted Amino Acids with some extra questions about pregnancy and nursing that I’m not often asked about. Katie is mom to 6 children and many in her community are moms too.

Here is some of what we cover in our interview:

  • nutritional deficiencies commonly linked to anxiety, depression, and other problems
  • my own story of recovery from severe panic attacks
  • why perfectionism and worry might have more to do with body chemistry than your personality
  • all about the key anti-anxiety amino acids: GABA, theanine, tryptophan, 5-HTP (and others)
  • how low vitamin D, low zinc, high copper, and other nutritional factors add to anxiety
  • the low zinc and high copper play a role in postpartum depression
  • the potential neurotransmitter issue that leads to cravings
  • biochemical reasons some people are introverted or socially anxious
  • guidance for pregnant moms who can’t take amino acids (and what to do if you’re nursing)
  • the way an MTHFR mutation is linked to anxiety and how to resolve it

Here is a snippet of our interview on the topic of how to assess for low neurotransmitters and do a trial of GABA or tryptophan, and how quickly they work:

Just like you test your vitamin D levels – that’ll tell you that you’ve got low levels and you need to supplement with vitamin D, then you’ll retest and see that your levels have come up. With the amino acids and the low neurotransmitters, I find using a questionnaire is the best way to assess the fact that you may have low GABA and you may have low serotonin. Then you do a trial of the amino acid based on your unique needs, and then you redo the questionnaire and you see how things have changed.

If you use these targeted individual amino acids based on your unique need, you can see results very quickly – within five minutes, and then over the course of the next few weeks you should be seeing results very quickly. Some people will say, “I’m not seeing any impact, should I keep trying, you know, how long should I be aiming for.” The thing that, about the amino is that are so amazing, is that you get results right away. If you don’t get results, it means it’s not enough or it means you don’t need it. The anxiety is not caused by low serotonin or low GABA.

I also talk about my personal experience with low serotonin and perfectionism:

I discovered low serotonin was a factor because although the GABA helped with the physical anxiety and the panic attacks, I still had this perfectionism issue. I remember working in that computer job and being called up to do an appraisal. And they told me I was too much of a perfectionist and I needed to let go a little bit. I couldn’t believe anyone could think that was a bad thing. So it was interesting how, as you start to implement some of these, you start to realize some of these other things that you may think is just a personality thing or it’s just me, it’s just the way I am – you realize that some of these things can be related to biochemical imbalances.

As I mention above Katie does ask me about using the amino acids during pregnancy and while nursing:

I don’t recommend anyone take them during pregnancy. It’s difficult advice for me to give because I know that there are so many issues with SSRIs during pregnancy. Because we don’t have the research, it’s not something that I can recommend. If you are prone to anxiety or you’ve had anxiety, get that sorted out before you get pregnant. I know, that’s easier said than done. A lot of women really want to get pregnant now or they are pregnant and then they realize that they’ve got the anxiety. So that’s a very difficult situation.

Once you’ve had the baby, if you are having really bad anxiety, obviously you’ve got to talk to your doctor and make sure that they are okay with you taking the amino acids right after nursing and then waiting four to six hours before nursing again. It is one way to do it. And then monitoring the baby to make sure that they are okay. There are actually two studies that came out recently showing that tryptophan and tyrosine, doesn’t seem to be an issue in breast milk.

You can listen to the entire interview (and download the interview mp3 file and read the transcript) via the Wellness Mama podcast #105 blog.

For additional information on products over and above those we covered in the interview here are some recent blogs:

Katie, is the “Wellness Mama” and her goal is to help other families live more naturally through practical tips, real food recipes, natural beauty and cleaning tutorials, natural remedies and more. Her blog is a wealth of information and if you don’t tune in to her podcasts and get her newsletter I encourage you to check her out.

Here are a few really good ones to get you started (although they really are all excellent!):

She shares this on her site: “my real goal with the blog is to help you and to create lasting changes so that our children can grow up in a better world.” I just love her mission and passion and all the very practical and safe solutions she offers!

Nutrition solutions for psychological stress after a natural disaster

By Trudy Scott 8 Comments

There is much that can be done nutritionally in support of psychological stress and PTSD (post-traumatic stress disorder) during and after a natural disaster. I’ve written this blog for you if you’ve been impacted by the recent storm and flooding due to Hurricane Harvey in the Houston area (the pictures of people returning home are so sad), and for everyone impacted by Irma and about to be impacted by Irma. This is for you if

  • you had to be rescued and had to evacuate your home, are displaced and/or saw neighbors in trouble, have lost your belongings and home – and anything else that may have happened during this natural disaster
  • you have been involved in on-the-ground rescue efforts or working online helping with rescue efforts and you have working long hours, not getting enough sleep and likely not eating well
  • you had a loved one in trouble and feared for their lives
  • and if you’re on observer feeling distressed by what you have witnessed

You may be feeling on edge and anxious about the future, fearful about losing your job, worried about expenses and the chemical soup of flood waters you were exposed to, exhausted and yet not able to sleep, feeling overly emotional and weepy, having nightmares and flashbacks and feeling frazzled.

I wasn’t even in Texas and my contribution was a very small one, helping online rescue efforts from Australia via a volunteer rescue group created by McCall McPherson, but I felt really burned out after just a few days and quite distressed by some of the rescues we were trying to facilitate. I have had to really walk my talk and implement some of what I’m sharing here even though I would consider myself resilient because my nutrient balance is good.

B-Complex for everyone

My first recommendation is a B complex and if this is all that can be managed it would be my first choice for everyone. In fact, if you live in an area prone to hurricanes, flood, fires etc. I’d recommend being on a B complex all the time.

My colleagues Bonnie Kaplin and Julia Rucklidge published this paper in 2015: A randomised trial of nutrient supplements to minimise psychological stress after a natural disaster. They share that:

After devastating flooding in southern Alberta in June 2013, we attempted to replicate a New Zealand randomised trial that showed that micronutrient (minerals, vitamins) consumption after the earthquakes of 2010-11 resulted in improved mental health. Residents of southern Alberta were invited to participate in a study on the potential benefit of nutrient supplements following a natural disaster.

Fifty-six adults aged 23-66 were randomised to receive one of the following for 6 weeks:

  1. vitamin D as a single nutrient
  2. a B-Complex formula or a
  3. broad-spectrum mineral/vitamin formula

The study participants monitored changes in depression, anxiety and stress via self-reporting. All of the above 3 groups showed substantial decreases on all measures. However, those consuming the B-Complex and the broad-spectrum mineral/vitamin formula showed significantly greater improvement in stress and anxiety compared with those consuming the vitamin D alone, with the results being similar for the group using the B-Complex and the broad-spectrum mineral/vitamin formula.

The authors report that:

The use of nutrient formulas with multiple minerals and/or vitamins to minimise stress associated with natural disasters is now supported by three studies.

Further research should be carried out to evaluate the potential population benefit that might accrue if such formulas were distributed as a post-disaster public health measure.

I would love to see either a B-Complex or broad-spectrum mineral/vitamin formula be given out to everyone as part of relief efforts for all natural disasters.

The B-Complex used in the study was made by Douglas labs but other similar B-Complex products would be fine too.  I happen to use Designs for Health B Supreme with my clients.

The broad-spectrum mineral/vitamin formula in the study was EmpowerPlus made by TrueHope.

From: A randomised trial of nutrient supplements to minimise psychological stress after a natural disaster

Vitamin D based on levels

In the above study, some participants in the vitamin D group did see benefits and it’s likely to have been those who were low in vitamin D at the time of the flooding since other research supports a connection between low vitamin D and anxiety and depression. I like to see vitamin D results before recommending supplementation.

Serotonin, GABA and endorphin support based on symptoms and a trial

As well as a B-complex and/or vitamin D, I’d also consider the following neurotransmitter support on a case by case basis, and after doing the amino acid questionnaire and a trial of each amino acid:

  • Serotonin support with Lidtke tryptophan or Lidtke Tryptophan Complete or Lidtke Combat Stress (a tryptophan product formulated for stress support) – especially if you’re feeling sad, worried, resolving to try and feel positive, imagining the worst, feeling fearful and having problem sleeping. I blogged about tryptophan products last week.
  • GABA support for physical tension and an increased need to self-medicate with alcohol in order to stay calm. New research shows that reduced plasma levels of GABA observed in PTSD could be considered as a possible biomarker for PTSD severity. This is not something I typically look at but it’s something I will be considering going forward. I blogged about some specific GABA products earlier this week.
  • Endorphin support with Lidtke DPA if you’re feeling especially emotional and weepy.

Serotonin and GABA play a role in stress resilience and when we have enhanced stress resilience mechanisms we have the ability to adapt more successfully to stressful situations like natural disasters.    

Additional adrenal support if needed

The adrenals are part of the hypothalamic-pituitary axis (HPA) and also need nutritional support after stress and trauma. I recommend a good adrenal support product with rhodiola, Vitamin C, pantothenic acid, eleuthero and ashwagandha. Designs for Health Adrenotone is a good product.

If it’s known that cortisol levels are high then the addition of Seriphos and/or a lactium product (such as Biotics Research De-Stress) helps to lower high cortisol, reduce anxiety and help with insomnia.

Additional pyroluria support if needed

It is well known that pyroluria symptoms are made worse in times of heightened stress. If you are on protocol for pyroluria, additional zinc and vitamin B6/P5P is likely going to be needed short-term too.

Essential oils

Essential oils like lavender and citrus are wonderful for the stress, anxiety and sleepless nights. An animal study reports that passively inhaling orange essential oil could potentially reduce PTSD symptoms in humans

 

Some other considerations include the following once things start to get back to some kind of normal:

I would recommend a similar approach for any natural disaster or in fact for any other traumatic event, always working individually with each person.  

If you have found some approach to be particularly useful for you please do share it.

And if you have any connections for getting this information into the hands of public health officials and non-profits offering aid please let me know. I feel that protocols similar to this one need to be made available to everyone subjected to a natural disaster.

I wish you and your families much healing and a speedy recovery.

Additional resources

I added these additional resources after September 20, 2017:

If you have links to additional useful resources please let me know and I’ll add them.