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Mindd 2019: The cell danger response and microbiome; and microchimerism and pregnancy

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Today’s blog highlights two interesting and very different topics that can impact both your mental and physical health: The cell danger response: inflammation, the microbiome and digestion; and microchimerism and how pregnancy can change the health of a mother in unintended ways.

I love to share resources after I’ve attended a conference but today I’m switching it up and sharing resources before the conference for three reasons: 1) to get you fired up and excited about attending in person (or on the Livestream) 2) to share in case you can’t attend in person (or via Livestream) and 3) to highlight the amazing work that the Mindd Foundation is doing via the Mindd Forum 2019, which will be in Sydney, Australia, March 23-24, 2019.

There’s also a giveaway of 2 free tickets to the Public stream (in-person or livestream) so read on below to see how to enter.

The cell danger response: inflammation, the microbiome and digestion

The cell danger response can cause increased inflammation and have direct impacts on the microbiome and digestion. The Cell Danger Response (also known as CDR)

is the intracellular response to stressors, viruses, chemicals or toxins and any foreign particles that come into the human system that need to be expelled. If the cell danger response is constantly being activated and is defective, it may cause a heightened prevalence and severity of inflammation.

The above article highlights the effects on the cell danger response on the microbiome, digestion and nutrient absorption, with ramifications for anxiety, depression, ASD (autism spectrum disorder), ADHD (attention deficit hyperactivity disorder) and many other conditions. Here are some highlights of what the CDR can impact the lower part of the colon

  • alter disaccharide metabolism, causing the lower/distal bowel to receive a more significant number of simple sugars and change carbohydrate digestion
  • alter the cells that line the intestines leading to differences in how amino acids are processed, affecting production of neurotransmitters such as GABA, serotonin and dopamine, with consequences for both your brain and gut health

Dr. Robert Naviaux coined the term CDR and will address these links in detail and explain current research with regard to the CDR, cellular healing and how to incorporate these concepts into practice. He will address the role this plays in the healing cycle and treating chronic disease, and specifics on CDR as it applies to understanding Chronic Fatigue Syndrome. His masterclass series is titled: Cellular Pathways for Chronic Disease Recovery.

According to Mindd, three of Dr. Robert Naviaux’s research publications were the most frequently downloaded papers in the journal Mitochondrion in the last 90 days, so this gives you an idea on the relevance of this topic.

Dr Nancy O’Hara also has a helpful explanation of the CDR here cover Clinical Applications of Dr. Naviaux’s research, together with Dr. Elizabeth Mumper.

It’s a pretty complex topic and I’ve been trying to get my head around it for some time. I blogged about some of his early research on CDR and the dramatic effects of a single dose of suramin on “social communication and play, speech and language, calm and focus, repetitive behaviors and coping skills” in 10 boys, ages 5 to 14 years, all diagnosed with autism.

What does all this mean for you?

  • Could the CDR be a factor in your chronic unresolved SIBO (small intestinal bacterial overgrowth)?
  • Could there be applications for anxiety for you if you have tried ALL the nutritional/biochemical approaches and are still not seeing symptom resolution?
  • Could addressing the CDR help you if you’ve been harmed by benzodiazepines, SSRIs and/or fluoroquinolones and can’t take any supplements or can only tolerate very small doses?
  • Could addressing the CDR help when you have a combination of many stresses like past or recent trauma, genetic defects, heavy metals, mold and Lyme, as well as gut issues and nutritional imbalances?

We clearly have much to learn in this area and I’m excited to hear more from these practitioners.

Microchimerism and how pregnancy can change the health of a mother in unintended ways

Pregnancy can change the health of a mother in unintended ways, sometimes causing harm and in other instances saving the mother’s life. Microchimerism is the “two-way implantation of cells between a mother and fetus.”

Approximately 50-75% of women carry immune cells derived from their fetus after giving birth. Not only that, but the offspring can also hold onto maternal cells too. The fetal cells present in a mother can be apparent for years after giving birth, and their role in human health is currently being investigated. Research is also evaluating the likelihood of whether an older sibling/previous pregnancy can pass cells to a current fetus of a different pregnancy.

The majority of research on microchimerism has investigated its potential to cause harm. This is due to a 1996 paper hypothesizing the link between microchimerism and the cause of autoimmune conditions. However, the connection between microchimerism and positive health outcomes has been receiving attention in the last few years. This is partly due to detecting the capability of mammals to save their mother’s lives by providing cells that are repairing tissue, including bone marrow, to replace dysfunctional cells.

While the mechanism of action is currently unclear, it is understood that microchimeric fetal cells can provide repair processes within maternal tissue, via cellular differentiation.

Leah Hechtman will be speaking at the Mindd Forum 2019 on Microchimerism, mRNA and Parental Wisdom. She will review the understanding of how pregnancy can change the health of a mother in unintended ways and “how we can influence unique genetic pathways to improve the health of future generations.” Read about Leah and more about this fascinating topic in the MINDD article on microchimerism.

Ideally, attend the conference in person. These topics will all be presented as part of both the Public stream and the Practitioner stream, and will also be available via Livestream – at the Mindd Forum 2019 (links below).

Other topics of interest being presented at the Mindd forum

Alexx Stuart from Low Tox Life is presenting in the Food Is Medicine program – Foods that Support Detoxification: Brilliant Brassicas!

Are you looking for clever ways to bring delicious inspiration to your plate? Learn how to incorporate brassica vegetables (Broccoli, Cauliflower, Brussels sprouts, Cabbage, Kale and more) – this vital family of veggies – to inspire detoxification and disease-fighting, every single day. From breakfast to snacks to family meals and even dessert!

Naturopath, Nutritionist and Mindd Ambassador Helen Padarin is presenting – Nutrition & Lifestyle that Supports Mitochondria

Many symptoms can be due to your mitochondria needing support. These can include waking tired, energy slumps, fatigue, trouble concentrating, poor muscle tone, speech difficulties, learning disabilities, Autism Spectrum Disorder, vision or hearing problems, exercise intolerance or heart, liver or kidney disease. If you haven’t yet heard about your mitochondria – it’s time to get to know them and learn how to treat them well! Mitochondria are highly intelligent energy producing engines in every cell in your body.

Gillian Koziciki of Cultured Artisans is presenting – Fermenting the Rainbow for Health & Vitality

Bidirectional communication between your gut microbiota and cellular mitochondria show a link to your health and energy levels. Feeding your gut healthy, probiotic foods increases the good bacteria of your microbiome which assists your mitochondrial health. The full colour spectrum of foods can be fermented to provide guerilla nourishment.

Both Dr. Mumper and Dr. O’Hara are presenting – A Functional Approach to Conditions On-the-Rise

Clinical pearls and case histories, testing and treatment on Lyme disease, ADHD, PANDAS & PANS, Alopecia, Vitiligo and Cutaneous Mastocytosis, migraines, rhinitis, asthma, eczema, Cerebral folate deficiency, Chronic inflammatory response syndrome (i.e. toxic mold issues), POTS & Dysautonomia, Autism, Celiac & non-celiac gluten sensitivity, and ADHD without drugs.

Here are all the links

The cell danger response and the microbiome – what’s the link?

What is the Cell Danger Response? with Dr. Nancy O’Hara

A new outlook on Microchimerism

Practitioner stream link

Public stream link

You can find the Mindd Foundation on facebook here.

Drawing to win a ticket to the Public sessions (2 tickets to be won) and 10% discount

If you’d like to be entered into a drawing to enter a ticket to the Public Stream (in-person or livestream):

  1. Comment below and share why you’d like to attend/listen in and what interests you about any or all of these topics
  2. AND share this blog with a friend, colleague and/or on social media. Be sure to mention where you shared it when you comment.
  3. AND let me know if you’d like to attend the Public track in person or do the livestream Public track

I have 2 tickets to give away and I’ll announce the winners on the blog Monday March 18 at 10pm PDT (USA) which is Tuesday March 19 at 4pm AEDT (Australia), and will email you directly if you’re a winner.

As a Mindd Ambassador, I am also thrilled to be able to offer a 10% discount to my community. Use the promotional code TRUDY10 at checkout to receive this discount (this is for both the practitioner and public tracks and the livestream).

Can you see any applications of the above for your health personally or for someone in your family, or a client/patient?

Feel free to post your questions here too and I’ll do my best to try and address them.

And don’t forget to comment and share the blog for a chance to win a ticket to the Public stream!

How to Beat Anxiety and Resolve Panic Attacks with Targeted Amino Acids: Wellness Mama podcast

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Today I share my wonderful interview with Katie, the “Wellness Mama”. We talk about my favorite topic: How to Beat Anxiety and Resolve Panic Attacks with Targeted Amino Acids with some extra questions about pregnancy and nursing that I’m not often asked about. Katie is mom to 6 children and many in her community are moms too.

Here is some of what we cover in our interview:

  • nutritional deficiencies commonly linked to anxiety, depression, and other problems
  • my own story of recovery from severe panic attacks
  • why perfectionism and worry might have more to do with body chemistry than your personality
  • all about the key anti-anxiety amino acids: GABA, theanine, tryptophan, 5-HTP (and others)
  • how low vitamin D, low zinc, high copper, and other nutritional factors add to anxiety
  • the low zinc and high copper play a role in postpartum depression
  • the potential neurotransmitter issue that leads to cravings
  • biochemical reasons some people are introverted or socially anxious
  • guidance for pregnant moms who can’t take amino acids (and what to do if you’re nursing)
  • the way an MTHFR mutation is linked to anxiety and how to resolve it

Here is a snippet of our interview on the topic of how to assess for low neurotransmitters and do a trial of GABA or tryptophan, and how quickly they work:

Just like you test your vitamin D levels – that’ll tell you that you’ve got low levels and you need to supplement with vitamin D, then you’ll retest and see that your levels have come up. With the amino acids and the low neurotransmitters, I find using a questionnaire is the best way to assess the fact that you may have low GABA and you may have low serotonin. Then you do a trial of the amino acid based on your unique needs, and then you redo the questionnaire and you see how things have changed.

If you use these targeted individual amino acids based on your unique need, you can see results very quickly – within five minutes, and then over the course of the next few weeks you should be seeing results very quickly. Some people will say, “I’m not seeing any impact, should I keep trying, you know, how long should I be aiming for.” The thing that, about the amino is that are so amazing, is that you get results right away. If you don’t get results, it means it’s not enough or it means you don’t need it. The anxiety is not caused by low serotonin or low GABA.

I also talk about my personal experience with low serotonin and perfectionism:

I discovered low serotonin was a factor because although the GABA helped with the physical anxiety and the panic attacks, I still had this perfectionism issue. I remember working in that computer job and being called up to do an appraisal. And they told me I was too much of a perfectionist and I needed to let go a little bit. I couldn’t believe anyone could think that was a bad thing. So it was interesting how, as you start to implement some of these, you start to realize some of these other things that you may think is just a personality thing or it’s just me, it’s just the way I am – you realize that some of these things can be related to biochemical imbalances.

As I mention above Katie does ask me about using the amino acids during pregnancy and while nursing:

I don’t recommend anyone take them during pregnancy. It’s difficult advice for me to give because I know that there are so many issues with SSRIs during pregnancy. Because we don’t have the research, it’s not something that I can recommend. If you are prone to anxiety or you’ve had anxiety, get that sorted out before you get pregnant. I know, that’s easier said than done. A lot of women really want to get pregnant now or they are pregnant and then they realize that they’ve got the anxiety. So that’s a very difficult situation.

Once you’ve had the baby, if you are having really bad anxiety, obviously you’ve got to talk to your doctor and make sure that they are okay with you taking the amino acids right after nursing and then waiting four to six hours before nursing again. It is one way to do it. And then monitoring the baby to make sure that they are okay. There are actually two studies that came out recently showing that tryptophan and tyrosine, doesn’t seem to be an issue in breast milk.

You can listen to the entire interview (and download the interview mp3 file and read the transcript) via the Wellness Mama podcast #105 blog.

For additional information on products over and above those we covered in the interview here are some recent blogs:

Katie, is the “Wellness Mama” and her goal is to help other families live more naturally through practical tips, real food recipes, natural beauty and cleaning tutorials, natural remedies and more. Her blog is a wealth of information and if you don’t tune in to her podcasts and get her newsletter I encourage you to check her out.

Here are a few really good ones to get you started (although they really are all excellent!):

She shares this on her site: “my real goal with the blog is to help you and to create lasting changes so that our children can grow up in a better world.” I just love her mission and passion and all the very practical and safe solutions she offers!

Anxiety and Depression Association of America 2013 conference highlights

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My gluten-mood poster at the 2013 ADAA conference
My gluten-mood poster at the 2013 ADAA conference

Last weekend I attended the annual conference of the Anxiety and Depression Association of America / ADAA and am pleased to share some of the highlights.

  • Gluten does have such a big impact on mood for so many people and I had many interested and curious visitors at my poster presentation (see the above picture)  “Evidence-based Research On The Serious Effects Of Gluten On Mental Health, With An In-depth Look At Testing And The Gluten-free Diet.” A number of people shared how gluten removal had eliminated their anxiety and/or depression too: a mom whose daughter quit gluten and found that this eliminated her panic attacks, a Canadian MD who didn’t know about gluten intolerance and infertility and the director of an anxiety clinic in Argentina. I was also honored to have Dr. Jerrold Rosenbaum, MD, ADAA Past President, Chief of Psychiatry, Massachusetts General Hospital and Professor of Psychiatry, Harvard Medical School, stop by. He said “interesting… everyone where I live is going gluten-free.” I asked him “and what kind of feedback are you getting?” Dr. Rosenbaum: “They’re all feeling better!”
  • I attended a great presentation by Dr. Teri Pearlstein: “Treatment of Perinatal Mood and Anxiety Disorders”. Dr. Pearlstein shared studies that show that babies born to depressed moms may have similar health problems as those born to moms taking anti-depressant medications i.e. lower birth weight and smaller head circumference. However, I also learned this: in a JAMA Psychiatry study of more than 1800 children, investigators found an adjusted 2-fold increased risk for ASD (autism spectrum disorder) among mothers who used an SSRI during the year before delivery and a 3-fold increased risk when SSRIs were ingested during the first trimester. The study was done in 2011 so it’s not new but it’s still an important finding. To me, this provides a very big incentive for using drug-free solutions for pregnancy – which is why the amino acids, fish oils and other nutrients that I cover in The Antianxiety Food Solution are worth investigating as a better option.  We really need some research in this area!

I’ll be sharing some other interesting posters (like “Mindful-based stress reduction for stress and cognition in older adults”) and presentations (like Benzodiazapine side-effects and tolerance) in my next post on the ADAA.