serotonin

Tryptophan, red meat and baby steps for anxiety: the Brain Summit

May 1, 2016 By Trudy Scott 18 Comments

Just a quick reminder that the Brain Summit starts tomorrow, Monday, May 2nd.

brainsummit-trudy

Here are some snippets from my anxiety interview with host Erin Matlock. We started out talking about diet and grass-fed red meat and why it’s so beneficial if you have anxiety (and other mood problems):

…there’s a lot of research showing now that [a Western diet] diet is not good for so many conditions, and mental health is now coming into the research. And we know this, but to see it in the research is really beneficial. Dr. Felice Jacka did a great study in Australia that was one of the first studies that looked at anxiety and depression in women and found that the Western diet was associated with a higher risk for anxiety and depression. And this whole foods, traditional diet, that actually included grass-fed red meat, was more beneficial for anxiety and depression. And in her thesis, they actually looked at red meat thinking that they would find that red meat was actually detrimental. And, lo and behold, they found that grass-fed red meat was one of the most important predictors for good mental health. So a lot of people say, “I don’t eat red meat any more. I’m being healthy.” And in actual fact, not eating it is doing them harm.

So red meat is wonderful! And it needs to be grass fed because then you’re getting the good levels of the Omega-3s. The Omega-3 three profile of grass fed red meat is very similar to what you would find in salmon. Obviously, fish is great, so while fish like salmon or sardines are great as well, the reason I like the red meat is it’s something that most people enjoy eating. And as well as the Omega-3s, we’re getting the iron, and iron is a co-factor for making serotonin and making GABA, and it’s needed for energy and so many other functions in the body.

It’s also got zinc, and zinc is a common deficiency, way more common than we realize. And when you are anxious, you may have high copper level, and low zinc level. So getting those zinc levels up will push the copper down, and that can help with your anxiety, as well.

We also had a long discussion on serotonin and tryptophan/5-HTP:

…we often associate serotonin with depression. And a lot of people don’t realize that it’s very closely tied to anxiety, as well. So we’ve got two types of anxiety when it comes to the brain chemicals. One is the low-serotonin type, and this is the anxiety in the head, where you’ve got the ruminating thoughts, and the busy mind, and the negative self-talk, and just this monkey mind that you can’t switch off — this worry, and sort of reprocessing things. And then we have the low-GABA kind of anxiety, where it’s in your physical body and you’re feeling stiff and tense, and you can feel it in your body, and you may feel it in your gut….

I have people do a questionnaire, and depending on how you score on that questionnaire, that’s a clue as to whether serotonin may be a factor. So all of those symptoms I’ve just mentioned, you would rate yourself on a scale of one to ten. And then I use individual, targeted amino acids. So it’s a supplement, and the other things that obviously have an impact are food, and diet, and everything we just talked about. Getting exercise, getting outside in the light, all of those are factors.

But for quick, immediate results, and pretty profound results – people just say to me, “Could this really be happening so quickly?” that’s how quickly we get results, you know, within 30 seconds to two minutes they’re getting results – is to use these individual amino acids as supplements. And the reason they’re called “targeted” is because it’s targeted to your unique needs. Like when you do the questionnaire and it says, yes, you need some serotonin support, and then you would use either tryptophan or 5-HTP as a supplement. And again, targeted, because you need it, but also targeted to your unique biochemistry.

There’s a standard starting dose for tryptophan, which is 500 mg, while 5-HTP is 50 mg.

Be sure to tune into the interview with Debbie Hampton. She is the survivor of an acquired brain injury (from a pill overdose when trying to commit suicide) and the author of the upcoming book, Sex, Suicide, and Serotonin. Her story and resilience is inspiring! Here is Debbie’s wonderful answer to Erin’s question: “What advice would you give to someone who feels like it’s too late to do what they want to do? I’m already so deep in, there’s no way that I could possibly have the life that I wanted or do the work that I really wanted to do.”

debbie-hampton

It’s never too late. And those limitations, you’re putting on yourself. Those limitations are in your mind. If you think you can’t, and you think it’s too late, then it is. You’ve got to change your mind first and if your mind thinks you can, you’re halfway there.

My advice would be to start small … I’m not big on long-term plans. I’m big on a long-term bigger goal. But what you’ve got to do is you’ve got to take a little step in the right direction towards that goal, and when you get there, you look around and you say, “Okay, what is my next best step?” And when you get to that next step, there may be opportunities that you can see that you couldn’t even see back here.

So you’ve got to take it one step at a time and get there and assess your opportunities. And then figure out the next best step, and then get there and figure out the next one. And it may be a zigzag path, and you may even have to go back sometimes, regress, but as long as you just keep moving forward and keep positive momentum and positive thoughts and be your own cheerleader, and encourager, and supporter— be your own friend—that is the most important thing.

I could not agree more – there is an answer, you can do whatever you set out to do and just take baby steps!

You can register for the Brain Summit here:
http://www.brainsummit.com?orid=45505&opid=12

Healing Anxiety through the Gut on the Heal Your Gut Summit

December 28, 2015 By Trudy Scott 8 Comments

Gut dysfunction can be linked to virtually every disease and can cause conditions like autoimmunity, fatigue, depression, anxiety and panic attacks, food sensitivities, chronic pain, allergies and many more. These conditions are by and large preventable.

Gut issues and anxiety often go hand-in hand and my interview addresses Healing Anxiety through the Gut:

Can you relate to the following phrases? “I have butterflies in my stomach,” “I can feel it in my gut,” or “I just have this awful feeling in the pit of my stomach.” These aren’t just figures of speech.

It can be difficult to assess which came first. Is the anxiety affecting your digestion, or did poor digestion lead to anxiety or make anxiety worse? Sometimes it’s a mixture of both, and both need to be addressed.

Digestive disorders are very common in the United States. Over a third of all adults are affected by some kind of digestive disorder, and each year forty-five million people visit the doctor for reflux, constipation, irritable bowel syndrome (IBS), liver disease, and other digestive complaints.

Studies have found that people with digestive complaints such IBS, food allergies and sensitivities, small intestinal bacterial overgrowth and ulcerative colitis frequently suffer from anxiety and also depression too.

One study found that 50 to 90 percent of people with IBS who visited a doctor for treatment also suffered from various anxiety disorders (panic disorder, generalized anxiety disorder, social phobia, and post-traumatic stress disorder) and major depression.

There are many factors that can be considered when it comes to anxiety and gut health: the microbiome and psychobiotics (or good bacteria), low serotonin and an amino acid like tryptophan, low levels of stomach acid, low zinc, food sensitivities and much more.

Join us for this fabulous upcoming online event that is being hosted by 3 of my favorite people: Dr. Josh Axe, who specializes in functional medicine and is on a mission to transform the health of millions all across the world; Donna Gates, the international best-selling author of The Body Ecology Diet and Dr. Eric L. Zielinski, a sought-after natural health educator, motivational speaker and author, and host of the well-known Essential Oils Summit.

I’m honored to have been invited to present with this excellent line-up of speakers that include:

Josh Axe, DNM, DC, CNS: 5 Steps to Heal Leaky Gut
Leo Galland, MD: Why Allergies Could Be Signaling Bigger Problems
David Perlmutter, MD: Heal Your Gut by Going Grain Free
Ty Bollinger: Boost Immunity with Gut-Immune-Cancer Connection

Here are some of the great speakers who I’ll be presenting with on day 5 of the summit:

I hope you can join us! You can register here https://ju127.isrefer.com/go/healyourgutreg/trudyscottcn/

5-HTP for anxiety, depression and insomnia: a clinically-effective serotonin precursor

October 16, 2015 By Trudy Scott 43 Comments

5-htp

5-Hydroxytryptophan or 5-HTP is an amino acid that increases production of serotonin in the brain alleviating anxiety, depression, insomnia, pain, carbohydrate cravings and more.

Here are some excerpts from an excellent paper published in Alternative Medicine Review in 1998 titled 5-Hydroxytryptophan: a clinically-effective serotonin precursor:

5-Hydroxytryptophan (5-HTP) is an aromatic amino acid naturally produced by the body from the essential amino acid L-tryptophan. Produced commercially by extraction from the seeds of the African plant, Griffonia simplicifolia, 5-HTP has been used clinically for over 30 years. The clinical efficacy of 5-HTP is due to its ability to increase production of serotonin in the brain.

In the central nervous system (CNS), serotonin has been implicated in regulation of sleep, depression, anxiety, aggression, appetite, temperature, sexual behavior, and pain sensation.

Therapeutic administration of 5-HTP has been shown to be effective in treating a wide variety of conditions, including depression, fibromyalgia, binge eating associated with obesity, chronic headaches, and insomnia.

I advise my clients to take all the amino acids between meals and away from protein containing food so they are no getting competition from other amino acids, thereby affecting absorption of the targeted individual amino acid they are taking. I typically make the same recommendation for taking 5-HTP however I simply do this to make things less complicated. In actual fact, 5-HTP can be taken with meals:

Intestinal absorption of 5-HTP does not require the presence of a transport molecule, and is not affected by the presence of other amino acids; therefore it may be taken with meals without reducing its effectiveness.

The recommended starting dose for 5-HTP is 50mg two or three times a day and it is well absorbed:

Initial dosage for 5-HTP is usually 50 mg three times per day with meals. If the clinical response is inadequate after two weeks, dosage may be increased to 100 mg three times per day. For insomnia, the dosage is usually 100-300 mg before bedtime. Because some patients may experience mild nausea when initiating treatment with 5-HTP, it is advisable to begin with 50 mg doses and titrate upwards.

5-HTP is well absorbed from an oral dose, with about 70 percent ending up in the bloodstream. It easily crosses the blood-brain barrier and effectively increases central nervous system synthesis of serotonin.

It’s well recognized that 5-HTP (and tryptophan) can impact both serotonin and melatonin levels but is often less recognized that other neurotransmitters can be increased too:

Other neurotransmitters and CNS chemicals, such as melatonin, dopamine, norepinephrine, and beta-endorphin have also been shown to increase following oral administration of 5-HTP.

You can read the complete paper here at altmedrev.com, a publication of Thorne Research Inc.

The author does seem to favor 5-HTP over tryptophan but I have found that many of my clients do better on one versus the other. I typically start my clients on tryptophan unless they have benefited from 5-HTP in the past. I would also recommend tryptophan at night if someone is wired-tired and adrenal testing shows high cortisol levels as 5-HTP can raise cortisol levels.

It really all comes down to our own biochemical individuality. I recommend doing a trial to see which amino acid is going to work for your symptoms. I write about this in this blog: How to do an amino acid trial for anxiety

Low serotonin MAY be a factor in anxiety and/or depression (and research shows this to be a fact). Anxiety and/or depression could have one of many possible causes – low serotonin, blood sugar instability, poor diet, not eating enough protein, sugar, caffeine, gluten, low dopamine (for depression), pyroluria, inflammation etc.

If low serotonin is a factor then 5-HTP (or tryptophan) is one way to start to raise serotonin levels so you can feel calm, confident, happy, pain-free again, as well as sleep through the night and end the afternoon and evening cravings.

Have you found 5-HTP to be effective? Please share how much you take/took and when, and how it made you feel. Did you also try tryptophan and do you prefer 5-HTP? We’d love to hear in the comments below.

Have you got questions? Feel free to ask in the comments below.

If this information sounds intriguing and you’d like practical help to figure out if you could possibly benefit from 5-HTP or one of the other amino acids, I invite you to join us in one of The Amazing Aminos for Anxiety homestudy group programs. This homestudy group program will provide guidance with using each of the targeted individual amino acids.

Amino Acids and Neurotransmitters: Trudy Scott’s MINDD interview

September 18, 2015 By Trudy Scott 16 Comments

mindd-interview

This time last year folks from the MINDD Foundation interviewed me at the Integrative Medicine for Mental Health conference. The MINDD Foundation helps practitioners and patients discover and implement effective treatments for Metabolic, Immunologic, Neurologic, Digestive, Developmental conditions that often affect the mind.

In this video I share about the amino acids tryptophan and 5-HTP for raising low serotonin levels, and the amino acid GABA for raising low GABA levels.

Here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution so you can see if low serotonin or low GABA may be a factor. Be sure to check the Amino Acid Precautions and work with your doctor if you are taking an SSRI.

Here are some useful related blog posts on the topic of amino acids:

It’s very timely to be sharing this information. In the recent webinar I shared that we know benzodiazepines do patients more harm than good and a brand new study shows that the psychiatric drug called Paxil, claimed to be a safe and effective treatment for depression in adolescents, is actually ineffective and associated with serious side effects. It is a reanalysis of an influential study originally published in 2001.

While the amino acids and other nutrients are powerful, we must always remember to get the foundations in place – real whole traditional food, no sugar, no caffeine and no gluten. This paper published earlier this year says it perfectly: Nutritional medicine as mainstream in psychiatry

Evidence is steadily growing for the relation between dietary quality (and potential nutritional deficiencies) and mental health, and for the select use of nutrient-based supplements to address deficiencies, or as monotherapies or augmentation therapies.

We advocate recognition of diet and nutrition as central determinants of both physical and mental health.

I will add that many of the recent “real whole traditional food” papers are not yet mentioning the mental health effects of gluten. Many say to include “whole grains.” So I’d like to share this wonderful testimonial recently posted on this blog: Bipolar, disruptive mood or gluten and junk food?

Ever since childhood I could not concentrate and focus at school. This seriously affected my grades. This continued into my working career and caused me to loose several jobs. Whilst I had periods of wellness this condition always returned to plague me. In one job as a retail manager I became driven for a six month period and then I crashed into deep depression sleeping for 18 hours a day. Prior to this crash I was stuffing my face with bread and fats. I was stressed and anxious. Ten years later this happened again.

I was diagnosed with bipolar 2. Only now at the age of 58 I discovered that I have an intolerance to wheat (gluten) after an elimination diet I feel so much better – all my symptoms are gone. It is like a MIRACLE! MY diagnosis is nonsense.

If the information in this video and article sounds intriguing and you’d like guidance with using targeted individual amino acids like tryptophan, 5-HTP and GABA (as well as glutamine and DPA/endorphigen), together with making diet and lifestyle changes, stay tuned for the launch of The Amazing Aminos for Anxiety homestudy group program.

You can add your name in the comments if you’d like to be notified when it launches. You’re also welcome to sign up here to be notified when we have more details about the start date.

Feel free to ask additional questions in the comments.

Low serotonin MAY often be a factor in anxiety and depression

July 17, 2015 By Trudy Scott 25 Comments

low-serotonin-anxiety

I recently received the following series of questions/comments (all from the same person) on my blog Targeted Individual Amino Acids for Eliminating Anxiety: Practical Applications and would like to share some of what I shared, plus some additional information.

Do you believe in the serotonin hypothesis? And that low serotonin is a factor in anxiety and/or depression? The serotonin hypothesis is a sales pitch from the pharmaceutical industry to sell psychotropic drugs. It is therefore very worrying that nutritional therapists found a market for sufferers and medicine addicts!
There is no test you can take today that show low serotonin in the brain? So where is the evidence?
Please read the books by Robert Whitaker, Peter Breggin and David Healy. Please read this article Things your Doctor Should tell You About Antidepressants and watch this Peter Breggin video

I’m sharing my response because these questions do come up periodically and you may hear other practitioners make similar statements. This is my response:

Yes, I do believe that low serotonin MAY be a factor in anxiety and/or depression (and research shows this to be a fact). I say MAY because anxiety and/or depression could have one of many possible causes – low serotonin, blood sugar instability, poor diet, not eating enough protein, sugar, caffeine, gluten, low dopamine (for depression), pyroluria, inflammation etc.

There is much evidence supporting low serotonin and depression/anxiety. Here are a few recent papers published in 2015:

In response to the question about testing serotonin levels: you can actually test serotonin levels via platelet testing. It’s the test that correlates most closely with CSF levels. A lab called European Laboratory of Nutrients (ELN)/formerly Vitamin Diagnostics offers this platelet serotonin test. It’s not a test that I use as I rely on the Amino Acid Questionnaire and response to the amino acids. I do not use Urinary Neurotransmitter testing.

With regards to the great article from Mad in America – I totally support these facts (for many individuals):

“antidepressant medications appear to do more harm than good as treatments for depression” and all the “harmful effects on other processes in the body” like digestion, sexual function, cognition etc.

I also respect Dr Peter Breggin’s concerns (in the youtube video) about biochemical imbalances in your brain being caused by the antidepressant drugs you are taking (such as Prozac or Paxil) and why we want to avoid them.

We know that anxiety and depression is not only caused by life stresses and trauma. There are physical biochemical imbalances, nutritional deficiencies, gut problems, food sensitivities, heavy metals and many more causes. I discussed 60+ Nutritional & Biochemical Causes of Anxiety during season 3 of the Anxiety Summit.

Low serotonin is just one of these possible contributing factors and we can address this with dietary and lifestyle changes:

Dietary changes include real whole food, grass-fed red meat, no sugar, no gluten, oily fish, healthy fats etc
Lifestyle changes include light therapy and exercise

Here are a few recent studies supporting the above:

“The effects of dietary tryptophan on affective disorders”
“Kefir protective effects against nicotine cessation-induced anxiety and cognition impairments in rats” (kefir is rich in tryptophan)
“Stress-Induced Depression Is Alleviated by Aerobic Exercise Through Up-Regulation of 5-Hydroxytryptamine 1A Receptors in rats”

The amino acid supplements tryptophan and 5-HTP are very powerful for providing immediate results of improved mood and reduced anxiety while the other factors are being addressed. We really need more research on the supplements. Here are two papers:

By boosting serotonin levels in my clients, I see incredible results on a daily basis. And with all this serotonin anxiety/depression research (literally thousands and thousands of papers), it just amazes me when I hear someone say that low serotonin is not a factor. It’s not THE ONLY factor, but is often one of any contributing factors.

If you are anxious or depressed and are still unconvinced, I encourage you to do the Amino Acid Questionnaire and a trial of tryptophan or 5-HTP and see how you respond. I’ve listed some brands I like on this blog: The Antianxiety Food Solution Amino Acid and Pyroluria Supplements.

If you don’t need convincing and have seen great results by boosting your serotonin levels please do share your experiences in the comments below so we can inspire others to look into this approach so they can feel wonderful too.

Holistic Solutions for Anxiety and Depression: review

June 12, 2015 By Trudy Scott 84 Comments

Although it is written for therapists I feel that Holistic Solutions for Anxiety and Depression: Combining Natural Remedies with Conventional Care, written by Dr. Peter Bongiorno, ND, is a great resource for anyone working with individuals with anxiety or depression, and this includes nutritionists.

As a nutritionist who works primarily with women with anxiety, I was so pleased to receive a physical review copy of this wonderful book. I did purchase the kindle but a real book is just so much nicer!

It’s also perfect for the anxious individual who taking charge of their own health and wants to become more empowered. It would also be a perfect book for the anxious person to share with their open-minded therapist or doctor.

Here are some of the reasons why I really enjoyed this book:

The extensive coverage of diet – Dr. Bongiorno favors a Mediterranean diet and cites research supporting this way of eating for mental health (I’d add more red meat and skip the grains, especially gluten)
The recommendation to eat crunchy vegetables based on the research about crunchy foods making us feel happier and calmer
The coverage of nutrients such as 5-HTP and tryptophan. Dr. Bongiorono will use 5-HTP first (he feels its “more effective at crossing the blood brain barrier) , whereas I tend to start with tryptophan. But he does say that “when dosed accordingly, tryptophan appears to be quite safe and effective.”
The coverage of GABA: “GABA supplementation helps open chloride channels in neurons, which hyperpolarizes them, so that the positive charges remain on one side of the membrane, which inactivates the nerve cell. This slows firing and calms the brain.”
The coverage of vitamin B3: one way it helps mood is “its ability to inhibit the liver enzyme tryptophan pyrrolase. This enzyme breaks down tryptophan making it less available to produce serotonin. Vitamin B3 is also responsible for activating the enzyme that converts tryptophan to 5-hydroxytryptophan.”
The coverage of lithium orotate: “It is suggested that lithium’s beneficial effects on mood may be due to its oxytocin-raising properties.” He suggests using it with an oxytocin-raising massage! Oxytocin also helps with social anxiety: Oxytocin and social anxiety, pyroluria and depression?
The fascinating discussion of the 5-HT1A receptor and oxytocin
The history of the discovery of serotonin (clams used it to keep their shells closed)
The coverage of light therapy, getting house-plants and a mind-body approach

As you can see, it includes plenty of geeky science, something I really love!

I had the pleasure of interviewing Dr. Bongiorno on The Anxiety Summit – our topic: Serotonin and Anxiety, Happiness, Digestion and our Hormones. Dr. Bongiorno’s speaking is as eloquent, factual and caring as his writing.

Dr. Bongiorno has been kind enough to offer a copy of his book as a giveaway. We’ll do a drawing and select one lucky reader and announce the winner next Friday. If you’d like to be entered in to the drawing simply comment below and share:

~~why you’d like to win the book~~
~~which section you’re most excited about reading and why (just go to the Amazon preview and check out the table of contents)~~
~~which holistic approaches you already use with patients/clients or you’ve used yourself~~

~~This drawing is open to practitioners and non-practitioners alike.~~

Peter Bongiorno, ND, a doctor of naturopathic medicine, is co-director of InnerSource Natural Health and Acupuncture in New York City. President of the New York Association of Naturopathic Physicians, he is a contributor to numerous blogs and online magazines, including DrOz.com and Sharecare.com, and is regularly interviewed as a natural medicine expert on national television and radio.