zinc

The Antianxiety Food Solution Amino Acid and Pyroluria Supplements

June 26, 2015 By Trudy Scott 674 Comments

antianxiety food solution and amino acids

Here are my amino acid and pyroluria supplement recommendations. These are the products I use with my one-one clients and those doing my online group programs.

You can find most of these products in my online store at Fullscript – you’ll find details here on how to set up and account (you just need to do this once) and make your purchase.

Purchase products through our Fullscript virtual dispensary.

Questionnaires and information

My publisher would not allow me to make specific product recommendations in my book so this list is a courtesy to those of you who have purchased the book.

If you do not have my book I highly recommend getting it and reading it before jumping in to taking supplements: The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings

There is a complete chapter on the amino acids and one for pyroluria, plus information on real whole food, sugar and blood sugar, gluten, digestion and much more.

Once you have read it you can use these blogs as summaries (they do contain some information that is not in my book).

Here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution and additional information on Anxiety and targeted individual amino acid supplements: a summary

Please read and follow these Amino Acid Precautions

Here is the Pyroluria Questionnaire from The Antianxiety Food Solution and additional information on Pyroluria, social anxiety, introversion: a summary

Here is a useful post: Pyroluria/social anxiety protocol: why aren’t I getting results? (trouble-shooting checklist)

Supplements for Low Blood Sugar (anxious, shaky between meals and intense sugar cravings)

Glutamine helps with low blood sugar, may help eliminate the strong desire for something sweet when opened on to the tongue, and is very healing for the digestive system

Pure Encapsulations L-Glutamine 500mg: L-glutamine (free-form) 500 mg, vitamin C (as ascorbyl palmitate) 5 mg. The capsules can be swallowed or the capsule can be opened on to the tongue
Designs for Health Glutamine Powder: This is a powdered glutamine that you can use right on your tongue or even mixed in water. The taste is quite pleasant.

Supplements for low GABA (stiff and tense muscles, anxious, panic attacks, use sugar/wine to relax)

GABA helps to raise GABA levels. I find GABA to be most effective when taken sublingually or opened on to the tongue. I find GABA to be more effective than pharmaGABA for most of my clients. I don’t ever use Phenibut (which the FDA recently removed from non-prescription use). Here are some GABA products that I like and use with clients.

Source Naturals GABA Calm (lozenges): This is a pleasant-tasting sublingual product that is my most popular and the most effective form of GABA I use with my clients. It is a lozenge that contains 125mg GABA, 5mg magnesium, 50mg glycine, 25mg tyrosine and 20 mg taurine. [AS OF NOV 24, 2021 THIS PRODUCT IS IN SHORT SUPPLY AGAIN]

[Note: this product is a lozenge with 125mg GABA and is not to be confused with the Source Naturals, GABA Calm Mind, 750 mg tablets]

Nutritional Fundamentals for Health GABA-T SAP: gamma-Aminobutyric acid (GABA) 300 mg, l-Theanine 150 mg. This is pleasant-tasting when opened on to the tongue and works very well when GABA Calm can’t be used. I find best results when it is used opened on to the tongue.

Thorne PharmaGABA-100: the label says Gamma-Aminobutyric Acid (GABA) 100 mg but it also states that the product uses Pharma Foods International’s Gamma-Aminobutyric Acid (PharmaGABA®). This is also pleasant-tasting when opened on to the tongue and is most effective when used this way. [AS OF NOV 24, 2021 THIS MAY BE UNAVAILABLE]

Thorne PharmaGABA-250: as above but contains 250mg of PharmaGABA®. This is also pleasant-tasting when opened on to the tongue and is most effective when used this way. [AS OF NOV 24, 2021 THIS MAY BE UNAVAILABLE]

Designs for Health PharmaGABA Chewables: gamma-amino butyric acid (pharmaGABA) 200 mg in 2 chewable tablets. It’s quick-acting and convenient like GABA-Calm because it’s chewable. This does contain xylitol, natural flavors, stevia and some other ingredients so taste may be a factor and xylitol can cause gas, bloating and diarrhea when too much is consumed.

Natural Factors PharmaGABA: gamma-amino butyric acid (pharmaGABA) 200 mg in 2 chewable tablets. It’s quick-acting and convenient like GABA-Calm because it’s chewable. However it also contains organic cane sugar and natural fruit flavors so it’s a little too candy-like for my preference, especially if you have low GABA-related sugar cravings. Also 2 chewable tablets – 4g of carbs which is almost 1 teaspoon of sugar!

[January 22, 2021/November 24, 2021: I’ve included this as a stand-by option for occasional use when Source Naturals GABA Calm is in short supply or if Designs for Health PharmaGABA Chewables are not available.]

Now Foods GABA Powder: 1/4 Level Teaspoon (500mg). This is pleasant-tasting when opened on to the tongue and is most effective when used this way. The only challenge with powder like this is making sure you don’t use too much by mistake. And it’s especially challenging when you only need 100mg. A mini measuring spoon set like this one (my Amazon link) is so easy and convenient to use and allows for accurate dosing.

Quicksilver Scientific Liposomal GABA with L-Theanine: 2ml (4 Pumps) provides (Gamma Amino Butyric Acid) 240mg, L-Theanine 100mg and Phosphatidylcholine 120mg (from purified sunflower seed lecithin). Spray and hold 30 seconds before swallowing. It does contain ethanol so would not be suitable for alcoholics or young children.

GABA-Pro Calming Effect Chewable: This is a chewable that contains 100 mg of pharmaGABA in 1 tablet. It is pharmaGABA even though the product says GABA-Pro on the front and the label states Gamma Amino Butyric Acid (GABA). It does contain natural flavors and xylitol. [This product is a reasonable replacement for Source Naturals GABA Calm when it’s not available (Nov 24, 2021)]

GABA-Pro Calming Effect: This contains 100 mg of pharmaGABA in 1 tablet. It is pharmaGABA even though the product says GABA-Pro on the front and the label states Gamma Amino Butyric Acid (GABA). This capsule can be opened onto the tongue. It does contain rice flour which can be an issue if you have a rice allergy/sensitivity and/or SIBO.

Designs for Health Stress Arrest: Niacin (niacinamide) 100 mg, Vitamin B6 (pyridoxine HCL) 10 mg, Pantothenic acid (d-calcium pantothenate) 100 mg, GABA 300 mg, Glycine 200 mg

Supplements for low serotonin (worry, rumination, negativity, afternoon and evening cravings and insomnia)

Tryptophan and/or 5-HTP can help to raise low serotonin. I typically recommend starting with tryptophan and don’t recommend 5-HTP if you have high cortisol as it can raise cortisol. Some people do better on tryptophan and some do better on 5-HTP.

Lidtke l-tryptophan 500mg: I only recommend the Lidtke brand for tryptophan as quality is a big consideration when it comes to this amino acid. This can be opened and/or chewed but doesn’t taste good. It can be mixed with inositol powder to make it more pleasant (see below) or with mashed banana. NOTE: This is not the same as the Lidtke Tryptophan Complete which has ingredients other than tryptophan making it more difficult to titrate up.

Lidtke l-Tryptophan Chewable: tablets contain 200mg L-Tryptophan per 2 tablets. This chewable form is both good and bad. It’s good because it’s a nice 100mg of tryptophan per tablet, is chewable, tastes good and is suitable for kids and “pixie dust” individuals (who need a very small amount). The bad aspect is that it does contain sugar and is quite sweet. Because you are continually consuming something sweet you may end up over-consuming them if sugar addiction is your issue.

Pure Encapsulations 5-HTP 50mg: Some of my clients do better on 5-HTP and some find taking this during the day and tryptophan at night works well for them.

Designs for Health Inositol: is fabulous for obsessive thoughts/behaviors that the tryptophan isn’t quite enough for. It’s also been shown to be very helpful for OCD itself. The powder has a slightly sweet taste and I recommend taking it in the powdered form. You can take up to 18g a day but I suggest starting with 2g a day and building up as needed. I think it makes a great addition for mixing into the nasty tasting tryptophan – I suggest starting with 2g inositol per 500mg tryptophan.

Douglas Labs 1mg melatonin sublingual: If the tryptophan isn’t enough for sleep issues, adding this often helps if you can’t fall asleep (and if it’s a low serotonin/low melatonin issue). Start with one and increase to 3 as needed

Douglas Labs 3mg melatonin prolonged release: If the tryptophan isn’t enough for sleep, adding this often helps if you wake in the night and if it’s a low serotonin/low melatonin issue. Start with one and increase to 2 as needed.

Supplement for low endorphins (comfort and reward eating, weepy, pain issues)

DPA or D-Phenylalanine is the amino acid that helps to raise endorphins and eliminates the comfort/reward eating and the feelings of “I deserve this” and LOVING certain foods

Lidtke Endorphigen 500mg: Riboflavin 5mg, Pyridoxal 5-phosphate 5mg (enzymatic form of vitamin B6), D-Phenylalanine 500mg. This is also one of my top products that I recommend. I used to recommend simply chewing the capsule to get the quickest and best effects and this worked well when it was produced in a gelatin capsule. Now it’s made with a cellulose capsule and chewing doesn’t work at all well so opening the capsule (or just biting off the top) and tipping the powder into your mouth works well. It does taste quite pleasant – some of my clients think it has a dark chocolate-like taste. A few people don’t like the taste at all but even then, it can be very effective when low endorphins are an issue.

Supplement for low catecholamines (tired, coffee-drinking, blahs, poor focus, low motivation)

Tyrosine is the amino acid that helps to raise low catecholamines and can often help you quit coffee if you “self-medicate” due to low catecholamines.

Progressive Labs tyrosine 500mg: 500mg l-tyrosine. This is the last amino acid I trial with my anxious clients because it can make you more anxious (although with one client it reduced her anxiety because she was able to focus better at work).

Vitamin C for negating the effects of any amino acid

Vitamin C 1000mg is used to negate the effects of any amino acid. I used to use EmergenC but this still contains folic acid, so here are some good alternate vitamin C recommendations:

Designs for Health C + Biofizz: Vitamin C 2569 mg (as Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate) Quercetin 20 mg Hesperidin 20 mg Rutin 10 mg. This one mixes nicely in water and can also be added to a smoothie but tastes quite sweet for many people. I personally prefer less of a sweet taste.

Designs for Health Buffered Vitamin C: Vitamin C (as ascorbic acid) 2000 mg, Calcium (as calcium ascorbate) 80 mg, Magnesium (as magnesium ascorbate) 160 mg, Potassium (as potassium bicarbonate) 200 mg. This one doesn’t mix very well in water and can also be added to a smoothie. The taste is not very pleasant.

The supplements for pyroluria

Zinc, vitamin B6, evening primrose oil and a good copper-free multivitamin are what I use for my clients with pyroluria or for those who score above 15 on the questionnaire:

Solaray OptiZinc 30mg. Zinc (as Zinc Monomethionine [OptiZinc®] 30 mg, Vitamin B6 (as Pyridoxine HCl) 20 mg. The zinc in this form seems to be well absorbed by many of my clients and is available over the counter. This also does not contain copper. Be aware as there are other OptiZinc products on the market that do contain copper (Source Naturals is one example)

Douglas Labs Opti-Zinc: Zinc (from 150 mg Zinc Monomethionine) 30 mg. The zinc in this form seems to be well absorbed by many of my clients. This also does not contain copper.

Metagenics Zinc Drink: Zinc sulphate monohydrate in a base of distilled water. Each 2 tsp provides Zinc sulfate monohydrate 8 mg. Use this for testing your zinc status as described here: Zinc deficiency is common: using liquid zinc status test as an assessment tool

Here are a selection of 100 mg Vitamin B6/pyridoxine products. Use dream recall as a way to monitor if it’s working, plus social anxiety and mood improvements. If this doesn’t work you may need to use the activated form in conjunction with or instead of this one (see below)

Progressive Labs 100mg Vitamin B6 (contains rice flour)

NOW 100mg Vitamin B6 (contains rice flour)

Vital Nutrients 100mg Vitamin B6 (Only B6 and glycine)

Klaire Labs 250mg Vitamin B6 (Use this one if you find you do better with more i.e. 250mg)

Pure Encapsulations P5P 50 (activated B-6): pyridoxal 5 phosphate (activated B6) 50 mg, vitamin C (as ascorbyl palmitate) 3 mg. This activated form of B6 may be needed if the 100-500 mg B6/pyridoxine doesn’t work or may be needed in addition to vitamin B6/pyridoxine. Use dream recall as a way to monitor if it’s working, plus social anxiety and mood improvements.

Designs For Health P5P 50mg: another good product with pyridoxal 5 phosphate (activated B6) 50 mg

Now Foods Super Primrose 1300mg: Evening Primrose Oil (Oenothera blennis) (Seed) 1.3 g (1300 mg) – 120 count. GLA is often low in pyroluria and EPO helps with zinc absorption and PMS symptoms.

Designs for Health Twice Daily Multi: This is a good copper-free multi. It also contains Folates (NatureFolate™ blend) 400 mcg instead of folic acid (no DFH products contain folic acid).

Free form amino acids and magnesium

Pure Encapsulations Amino Replete: A free form amino acid powder blend that does contain tryptophan. It does contain fructose, flavors and luo han guo

Allergy Research Free Aminos: A free form amino acid blend in capsules. It contains 5-HTP and not tryptophan. I’d prefer it if it had tryptophan.

Designs for Health Amino Acid Supreme: A free form amino acid blend powder that does contain tryptophan. It is sweetened with stevia and contains natural flavors.

Designs for Health Magnesium Malate 360mg

Liquid and powder options for children

Here are some liquid and powder options for children (or for adults, if you have a hard time swallowing pills):

Carlson 100mg B6: Use dream recall (and no more nightmares) as a way to monitor if it’s working, plus improvements in social anxiety and mood.

Designs for Health 50mg P5P (with a little zinc and magnesium): This is the activated form of B6. Use dream recall (and no more nightmares) as a way to monitor if it’s working, plus improvements in social anxiety and mood.

Pure Encapsulations 15mg Zinc gluconate: A liquid zinc option.

Metagenics 15mg Zinc (as zinc sulfate): A liquid zinc option.

Designs for Health Zinc Challenge: Zinc sulphate monohydrate in a base of distilled water. Each 2 tsp provides Zinc sulfate monohydrate 8 mg. I use this for testing zinc status but it could be used as a supplement too.

BodyBio evening primrose oil: Gamma Linolenic Acid/GLA (omega-6) 473 mg. GLA is often low in pyroluria and EPO helps with zinc absorption, eczema and PMS symptoms.

Klaire Labs Vitaspectrum multivitamin/mineral: This is a great copper-free, iron-free powdered multi for kids. You can mix the powder directly into room temperature or cold foods or beverages just before serving.

Pure Encapsulations Amino Replete: A free form amino acid powder blend that does contain tryptophan. It does contain fructose, flavors and luo han guo.

Pure Encapsulations Magnesium Citrate 250mg powder

Designs for Health Magnesium Bisglycinate Chelate 300 mg powder: This one does have stevia and natural flavors

Also see chewable tryptophan, GABA Calm and inositol powder, plus powdered Vitamin C (all listed above).

What about international orders?

Unfortunately, Fullscript does not ship internationally.

So we suggest folks try an intermediary shipping service like www.shipito.com (we haven’t used them as of yet, so do your own research, and if they or someone else does work out please let us know in the comments below).

An alternative is to use iHerb to get similar products, as they ship worldwide and may even have a branch in your country for free shipping.

Here is the link for iHerb and to get 5% off, and if you are interested in iHerb’s exclusive brands to get 10% off here.

Can Social Anxiety Be Reversed with Nutrition?

May 29, 2015 By Trudy Scott 62 Comments

Sean Croxton host of Underground Wellness Radio shares how:

he was once prescribed Paxil for social anxiety (and depression)
he doesn’t like big crowds
he can speak on stage in front of 100s of people with no problem
as soon as people come to talk to him afterwards he wants to go!

Can you relate to any of this?

He thinks he has pyroluria, a social anxiety condition where you have a higher need for some key nutrients: zinc, vitamin B6 and evening primrose oil.

We are often surprised when we hear that someone who appears to be outgoing and extroverted (like Sean) actually has social anxiety.

It’s more common than you think and is made worse under stressful situations: life stresses, gluten sensitivities etc.

I share how my social anxiety got really bad in my late thirties (when my PMS was so bad) and how

many of us with pyroluria push through and deal with it
we just want to stay home
we don’t really want to see people

Not everyone needs omega-3 supplements!

We discuss omega-3s and omega-6s and how pyrolurics often don’t need to supplement with omega-3s like fish oils but can extract the omega-3s from the foods they eat: grass-fed red meat, wild fish like salmon, leafy greens and walnuts.

Pyrolurics often do need to supplement with the GLA form of omega-6 that we find in evening primrose oil as GLA is often low, plus the GLA enhances zinc absorption.

(by the way: I said alpha linolenic acid (ALA) but should have said gamma linolenic acid (GLA)

A good copper-free multi is part of the protocol because low zinc often means high copper and this can make you more anxious.

Looking at other sources of copper is a helpful for many pyrolurics: eating too many nuts, baking with nut flours, the copper IUD.

You don’t want to miss this part…Sean asks if you can cure introversion with this pyroluria protocol. If you are an introvert and force yourself in social settings, feel very uncomfortable and anxious being around big groups of people then you’re going to have to watch the end of the video for my answer!

You can watch the whole snippet here

This is part of my interview on the Depression Sessions, an online event hosted by my friend Sean. I’ll also be sharing information about the amazing amino acids – inexpensive, over-the-counter supplements that can lift your mood and end anxiety in minutes!

Sean traveled the country to interview the best of the best experts — medical doctors, naturopaths, nutritionists, and bestselling authors — on what really causes depression and anxiety and what to do about it.

Some of us (like me) flew to San Diego to be interviewed in his home. It was such a thrill to be interviewed by the legendary Sean Croxton and is an honor to be part of this group of experts!

Here are just a few of the amazing experts you’ll hear from:

Suzy Cohen, also known as America’s Pharmacist, uncovers specific prescription drugs that rob your body and brain of mood-friendly nutrients.

Datis Kharrazian will show you what insomnia, anxiety, and the symptoms that tag along with depression can tell you about what’s causing it.

Hyla Cass, a medical doctor and integrative psychiatrist (who has been featured on two prior Anxiety Summits), shares her best tips for transitioning OFF of psychiatric meds while avoiding or minimizing common withdrawal symptoms.

Ben Lynch (another Anxiety Summit favorite) reveals the incredibly common genetic mutation known to drive depression (and anxiety) … and the critical nutrients that make such a big difference.

Pyroluria/social anxiety protocol: why aren’t I getting results? (trouble-shooting checklist)

May 16, 2015 By Trudy Scott 118 Comments

How do you trouble-shoot when you score high on the Pyroluria Questionnaire from The Antianxiety Food Solution or even have a positive pyroluria urine test but you don’t seem to be getting the results you expect?

You still have social anxiety, that inner tension that you push through and deal with, and likely still feel uncomfortable when in large groups. You force yourself to put on the confident brave face. You may wish you could be more like your extrovert friends and actual enjoy socializing and speaking in public/on stage – without the fear and anxiety. You may still not be a big breakfast eater and have morning nausea. You may not yet be having pleasant dreams that you always remember.

(If pyroluria is new to you here is the Pyroluria Questionnaire from The Antianxiety Food Solution and here is a nice summary – Pyroluria, social anxiety, introversion: a summary )

This checklist is a starting point to try and figure out what may be the issue. These are the questions I work through with someone who is working with me one-on-one.

I discussed 21 of these in my interview on season 3 of the Anxiety Summit: Pyroluria, Amino Acids and Anxiety: Troubleshooting when you are not getting results

As you heard during the interview, I added MTHFR and I’ve even added a few more since then. I expect this list to continue to grow.

What form of zinc are you taking and is it free from copper? My favorite is Optizinc (zinc monomethionine) as it’s typically well-absorbed
Have you made sure that there is no copper in your multivitamin or other supplements? (this completes with zinc)
Have you been taking evening primrose oil and if yes, how much? (this enhances zinc absorption)
Did you test your fatty acid levels? What are the results? Did it show a need for GLA (I like evening primrose oil rather than borage oil) and no need for omega-3s (pyrolurics typically don’t need to supplement with omega-3s like fish oil)
What is your alkaline phosphatase (a blood test)? Less than 70 may indicate a need for zinc
Have you done the zinc tally/challenge with zinc sulfate and does it taste like water or does it taste really bad? If you zinc levels are good it should taste really bad
Did you test copper and ceruloplasmin, and if yes, what were the results?
Did you do the pyroluria urine test? What are the results?
What’s your score on the pyroluria questionnaire ? And which symptoms do you have?
What is your score on the introversion questionnaire?
What were your dreams like before starting the protocol and now? How high did you go on the vitamin B6? Did you switch to P5P and/or use a combination of both if needed?
On a scale of 1-10, what was your social anxiety before and now (10 is worst)
What is your stomach acid like? And have you trialed HCl supplements? Tested total protein (in blood)
Do you eat grass-fed red meat (a good source of zinc, iron and omega-3s)?
Do you eat sugar? Refined sugar and processed foods? Or even “healthy” sweeteners such as honey in large quantities? (sugar depletes zinc)
Do you eat large quantities of nuts or bake with nut flours? (the copper in the nuts may be affecting your zinc levels)
Do you have a copper IUD, copper pipes, copper pots? (this may also affect your zinc levels, keeping them low)
Have you done a hair analysis and found high copper or high hidden copper? (this may also affect your zinc levels, keeping them low)
How much and how often do you exercise? What about bikram/hot yoga? (sweating depletes us of zinc)
Have you used any of the amino acids? And seen good results? (this could be a clue that zinc and vitamin B6 are low since they are cofactors for making neurotransmitters such as serotonin, GABA, dopamine)
Do you eat gluten and have a gluten sensitivity? If yes, have you healed your gut? If not, you may have malabsorption issues
Are you completely grain-free? (this may be impacting your vitamin B6 levels)
Do you have amalgams/silver fillings? Did you have them removed and did a mercury detox? Were you tested for heavy metals? (zinc absorption can be blocked by heavy metals – we talked about this in season 2)
Do you have the MTHFR polymorphism? It’s common with pyroluria and this may mean you need higher amounts of the supplements
Do you have high histamine/hisadelia or low histamine/histapenia? Pyrolurics often have one or the other
Are you taking benzodiazapines or have recently quit benzodiazapines? Your unresolved anxiety may be due to this fact (we talked about this in season 1)
Do you have parasites, candida, dysbiosis, SIBO or other digestive issues? These can be considered stresses and pyroluria symptoms are worse under stress. Digestive issues also impact absorption
Do you have Lyme disease or another infection? These can be considered stresses and pyroluria symptoms are worse under stress. The immune system also uses up zinc.
Do you have food sensitivities? This may contribute to malabsorption. This can also be considered a stress and pyroluria symptoms are worse under stress
Do you have problems with histamine-containing foods? This can be considered a stress and pyroluria symptoms are worse under stress. Also, vitamin B6 is a co-factor needed for the DAO enzyme, which is responsible for the degradation of histamine.
Do you have issues with oxalates? This can be considered a stress and pyroluria symptoms are worse under stress. Oxalates can also bind to minerals and lower the levels. For some folks vitamin B6 helps with oxalate issues so the need may be higher.
Have you been/are you exposed to mold and other toxins? These can be considered stresses and pyroluria symptoms are worse under stress. The immune system also uses up zinc.
Do you have low oxytocin levels? Do you have a genetic variation in the oxytocin receptor gene (OXTR). Oxytocin has been implicated in anxiety, depression and related stress phenotypes
Is your life super-stressful or have you suffered from a recent trauma (or have old unresolved trauma)? Stress and trauma makes pyroluria worse
Do you have adrenal issues? We need good adrenal function for optimal digestion, being able to handle stress and being able to fight off infections/avoid getting parasites and dysbiosis
Do you have hormonal issues – PMS, perimenopausal or menopausal symptoms? The pyroluria protocol helps and this could be a clue that something is off
Are you on the birth control pill or have used one in the past? Oral contraceptives cause low vitamin B6 and zinc, reduce serotonin levels and increase anxiety.
Are you on any other prescription medications? Many medications deplete B vitamins and zinc.
Do you have vagus nerve issues? Good vagus nerve function is key for digestion, immunity, inflammation, neurotransmitter production and so much more. Also, forcing yourself to socialize when you have pyroluria is stressful and impacts the vagus nerve
Do you have inflammation and/or immunity issues? Vitamin B6 plays a role in reducing inflammation and immune modulation

[August 2021: the above list was updated extensively]

This list is NOT exhaustive and it’s NOT in my book The Antianxiety Food Solution because I gathered this information after the book was published. However, the pyroluria questionnaire, detailed protocol and testing information is in the book. There is an entire chapter on pyroluria.

Keep in mind that most folks do the pyroluria questionnaire, start on the recommended protocol of zinc, vitamin B6 and a copper-free multi and start to see improvements in a week. These can be dramatic improvements for many folks. And many folks see decent improvements in a few weeks and tweak things over the next few weeks before landing on the ideal doses.

This blog is for you if this doesn’t happen.

Did you miss this interview or want this and the other great interviews for your learning library? You can purchase the MP3s or MP3s + transcripts and listen/read when it suits you. You can find your purchasing options here: Anxiety Summit Season 1, Anxiety Summit Season 2, and Anxiety Summit Season 3.

Feel free to share your results in the blog comments and what you figured may be the issue/s for you.

If you tweak something and it helped do let us know too. That way we all help each other.

And feel free to ask questions in the comments too.

The Anxiety Summit – Micronutrients for Eliminating Anxiety

May 13, 2015 By Trudy Scott 22 Comments

Mira Calton CN and Jayson Calton PhD, micronutrient specialists, authors of Naked Calories, are interviewed by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

Micronutrients for Eliminating Anxiety

The importance of micronutrient sufficiency and Mira’s osteoporosis
The Calton’s 6 year, 135 country expedition to explore traditional diets
The definition of naked calories
How glyphosate/Roundup impacts mineral absorption in plants and thereby impacts us
The new GM arctic apple and why it should be avoided
How minerals compete for absorption
Zinc/copper balance and why we want a multi with no copper

Here are some snippets from our interview:

When food is picked early it doesn’t have all the micronutrients

Spraying our food with glyphosate (Roundup) is starving our food of nutrients because it doesn’t allow the roots to absorb minerals from the soil so the plant is less micronutrient-rich

When you sweat, you become more deficient in micronutrients

The Arctic Apple doesn’t brown when it’s cut open and looks visually good but it’s really rotten and has lost the micronutrient value

They are really passionate about this topic of Arctic apples – as you heard in the interview and as you’ll see in this excellent Arctic apple blog

There is a relationship between micronutrients and there is this web of competition. Here are a few examples Mira and Jayson talked about:

Iron is the most competitive

Zinc and copper compete for absorption

Magnesium can affect zinc absorption

The zinc-copper discussion was fascinating. Mira and Jayson mentioned copper/iron position of the Physicians Committee for Responsible Medicine: Doctors Urge FDA to Ban Multivitamins Containing Iron or Copper

The Physicians Committee (for Responsible Medicine) urging the Food and Drug Administration to require vitamin manufacturers to reformulate common multivitamins that contain iron or copper, due to possible links with Alzheimer’s disease.

I wholeheartedly agree with this concern about copper and iron in multivitamins. My concern is with copper connection to lower zinc in anxiety and depression. (Just a heads up: I’m not on board with the Physicians Committee’s dietary recommendations on vegetarianism.)

Here are two of the papers I mentioned at the end of the interview

Zinc prevents sickness behavior induced by lipopolysaccharides after a stress challenge in rats.

Lipopolysaccharide or LPS is an endotoxin that mimics infection by gram-negative bacteria

Zinc treatment was able to prevent sickness behavior in LPS-exposed rats after the stress challenge, restoring exploratory/motor behaviors, communication, and TNF-α levels similar to those of the control group.

They found that zinc treatment appears to be beneficial for sick animals when they are facing risky/stressful situations

Possible involvement of corticosterone and serotonin in antidepressant and antianxiety effects of chromium picolinate in chronic unpredictable mild stress induced depression and anxiety in rats.

In the present study, we investigated the effects of chromium picolinate (CrP) on behavioural and biochemical parameters in chronic unpredictable mild stress (CUMS) induced depression and anxiety in rats.

The results showed that treatment of CrP produced significant antidepressant effect

It was also found that CrP (8 and 16μg/mL) significantly increased 5-HT [serotonin] concentration in the discrete regions of brain (cortex and cerebellum).

On the other hand, the plasma corticosterone level was significantly decreased with CrP (16μg/mL).

The results suggested that increase in the concentration of 5-HT/serotonin and decrease in plasma corticosterone levels could be responsible for improvement in symptoms of depression and anxiety in CUMS induced depression and anxiety in rats.

Here are two of their great books:

Naked Calories: The Calton’s Simple 3-step Plan to Micronutrient Sufficiency

And Rich Food Poor Food: The Ultimate Grocery Purchasing System (GPS)

Be sure to grab their amazing gifts:

A PERSONAL Micronutrient Sufficiency Analysis
Rich Food, Poor Food chapters
Micronutrient Miracle Guide to Reducing Stress, Anxiety and Depression;
NUTREINCE SAMPLE PACK & COUPON; and more

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here: www.theAnxietySummit.com

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Oxytocin and social anxiety, pyroluria and depression?

March 27, 2015 By Trudy Scott 66 Comments

A 2014 paper published in the Journal of Psychiatric Research looked at how variations in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress. Here are some excerpts from this paper:

Oxytocin is a neuropeptide that is involved in the regulation of mood, anxiety and social biology.

Genetic variation in the oxytocin receptor gene (OXTR) has been implicated in anxiety, depression and related stress phenotypes.

In this study, we examined genotypes in 653 individuals and tested whether SNP variation in OXTR correlates with severity of features of self-reported experience on the Depression Anxiety and Stress Scale (DASS), and whether this correlation is enhanced when early life trauma is taken into account.

The study found a significant effect of several oxytocin receptor genes (OXTR genotypes) on anxiety, stress and depression scores. They concluded that:

These results support the hypothesis that the oxytocin system plays a role in the pathophysiology of mood and anxiety disorders.

In this 2015 paper published in Neuropsychopharmacology, they looked at “Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder” and found that oxytocin lessened anxiety by dampening amygdala reactivity to threat in individuals with generalized social anxiety disorder.

Results indicated that in individuals with generalized social anxiety disorder:

Oxytocin enhanced functional connectivity between the amygdala and the bilateral insula and middle cingulate/dorsal anterior cingulate gyrus during the processing of fearful faces

These findings suggest that [oxytocin] may have broad pro-social implications such as enhancing the integration and modulation of social responses.

We know that low serotonin can cause anxiety, worry and depression and research shows there are interactions between oxytocin and serotonin levels. So if you don’t respond to serotonin support (tryptophan or 5-HTP or light therapy), maybe boosting oxytocin is a possible solution? Or maybe supporting serotonin will boost oxytocin?

What is also really interesting to me is that zinc is needed for binding oxytocin to its receptor so I wonder about the oxytocin connection to pyroluria, a social anxiety condition where higher amounts of zinc and vitamin B6 are needed. I wonder if adding oxytocin to the mix or boosting it would help even more? Or if optimizing zinc use and absorption would help promote oxytocin?

Have you had your oxytocin levels tested? Have you used oxytocin with good results and did it help your social anxiety/pyroluria and/or depression? Have you done anything else to boost your oxytocin levels?

Pyroluria and chronic fatigue syndrome: is there a link?

January 16, 2015 By Trudy Scott 21 Comments

pyroluria and chronic fatigue

Last week I blogged about the social anxiety condition called pyroluria (Pyroluria, high mauve, pyrrole disorder, malvaria, elevated kryptopyrroles and social anxiety) and received some great comments on this and the other pyroluria blogs.

One question on this blog: The Anxiety Summit: How zinc and vitamin B6 prevent pyroluria and social anxiety was related to Chronic Fatigue Syndrome/CFS so I’ve decided to share this and some additional information I was able to find.

Hi Trudy, I’m calling from Melbourne Australia, I was wondering if you have had any of your clients present with Chronic Fatigue Syndrome as well as pyroluria. I have just recently been diagnosed with CFS, I also have ADHD. Someone on a CFS forum that I belong to told me about pyroluria and said it is common in ADHD and CFS sufferers. While the link between ADHD and pyroluria is well documented, I haven’t been able to find any information regarding a connection between Chronic Fatigue Syndrome and pyroluria. I notice that there is an overlap of symptoms in the two conditions. I have all of the symptoms of CFS and many of the symptoms of pyroluria. I’m very interested in hearing your views about CFS and how it relates to pyroluria if at all. — Tom

I was not aware of a CFS/pyroluria connection until now but see there is some research showing how CFS and mood disorders/anxiety can have related causes and one of them is inflammation:

An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways

Low zinc is a factor in pyroluria and depression and of course we may also see low zinc in CFS:

Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS

I find this paper very interesting since many of these same nutrients are commonly low in folks with anxiety and depression: Nutritional strategies for treating chronic fatigue syndrome

A detailed review of the literature suggests a number of marginal nutritional deficiencies may have etiologic relevance. These include deficiencies of various B vitamins, vitamin C, magnesium, sodium, zinc, L-tryptophan, L-carnitine, coenzyme Q10, and essential fatty acids.

I’m surprised the above paper didn’t mention iron anemia. This is very common with pyroluria. This paper: Iron insufficiency and hypovitaminosis D in adolescents with chronic fatigue and orthostatic intolerance found this

In patients presenting with chronic fatigue and/or orthostatic intolerance, low ferritin levels and hypovitaminosis D are common

These are just a few of the links I found by doing a very quick pubmed search. There are likely many more.

Everything is so connected and inter-related! And it’s interesting how certain deficiencies can manifest in certain ways – one person may find themselves with a CFS diagnosis, someone else with arthritis and yet someone else with heart disease. I think we need to be thinking about addressing nutrient deficiencies, balancing biochemistry and getting healthy, perhaps more just than addressing a diagnosis.

If you score high on the Pyroluria Questionnaire I would suggest simply addressing the pyroluria which may have some ripple down effects and actually improve the symptoms of CFS.

Now the next post will have to dig into the link between ADHD and pyroluria. Stay tuned.

In the meantime, I’d love to see your comments/questions if you can relate to any of this. Also, please do share in the comments if you know you have pyroluria and find the nutrients have eliminated your social anxiety and inner tension symptoms, and have also helped your CFS.