environmental

Tryptophan doesn’t work, then it does and then it doesn’t: could it be hormonal shifts, dietary factors and/or parasites?

November 26, 2021 By Trudy Scott 19 Comments

Have you been in a situation where tryptophan doesn’t work, then it does work, and then sometimes it doesn’t work as expected? There is a reasonable explanation as to why it may not work initially – too much or too little was used. The variable results and the need to switch between lower and higher doses on an ongoing basis can happen but it’s not very pronounced unless there is a specific reason. In this blog I cover some of these reasons – hormone shifts, dietary factors and parasites/other digestive issues.

I’m writing this blog in response to a question that was posted on one of my speaker pages on the Anxiety Summit: Gut-Brain Axis. This is the actual question:

I tried to use tryptophan the first time (whole capsule) and got really high. Some time later I tried again, but used 1/4 of a capsule and had a good result. A few weeks later 1/4 of the capsule didn’t work at night. So I went up to half a capsule. And that’s where I am now. But some nights (very rare) I can only get good results from a whole capsule. I use it along with the same amount of GABA. Is that a normal reaction for tryptophan?

I don’t know what brand of tryptophan she was using but assume 500mg was her starting dose and she now shifts between 125 mg (¼ capsule) and 250 mg (½ capsule) with variable results.

It’s not unusual for someone to not feel great on 500 mg if that dose is too much for their unique needs. She did the right thing by lowering her dose. It’s also reasonable that someone may find 500 mg as an initial dose isn’t enough to reduce symptoms.

The variable results and the need to switch between 125 mg and 250 mg can happen but it’s not very pronounced unless there is a specific reason. Some of these reasons include hormone shifts, dietary factors, parasites/other digestive issues, thyroid issues, low lithium, product quality and environmental factors. More on all this below.

Hormone shifts/more serotonin is needed in the luteal phase

I have my clients track when the variability happens, with female clients documenting their cycles. Some women need more serotonin support in the luteal phase i.e. after ovulation and right up to before their periods. Some may even need additional tryptophan for the first few days of their periods too.

Write about tryptophan working well in the luteal phase in this blog – Tryptophan for PMS: premenstrual dysphoria, mood swings, tension, and irritability

In a study published in 1999, A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria, tryptophan was found to reduce symptoms of PMS when used in the luteal phase or second half of the cycle (i.e. after ovulation):

37 patients with premenstrual dysphoric disorder were treated with L-tryptophan 6 g per day, and 34 were given placebo. The treatments were administered under double-blind conditions for 17 days, from the time of ovulation to the third day of menstruation, during three consecutive menstrual cycles.

They looked at dysphoria, which is defined as a state of unease or generalized dissatisfaction with life, plus mood swings, tension (and anxiety), and irritability and they found a 34.5% reduction of symptoms with tryptophan compared to 10.4% with placebo.

The paper concludes: “that these results suggest that increasing serotonin synthesis during the late luteal phase of the menstrual cycle has a beneficial effect in patients with premenstrual dysphoric disorder.”

It’s a small study but the results are powerful and it’s something I see clinically with my clients. The one big difference is that I typically have clients using tryptophan throughout the month.

But if you are seeing tryptophan work and then not work at similar times each month this is something to consider and track. And then if need be, increase and decrease tryptophan accordingly (and track again).

Dietary factors – collagen, gluten, sugar, wine and coffee

There are other factors to consider too and dietary impacts is one. For example, collagen leads to a higher need for tryptophan in susceptible individuals (due to it’s serotonin-lowering effects – I blog about this here)

Another dietary factor is accidental gluten exposure in susceptible individuals or a newly discovered gluten issue

High sugar intake, alcohol and/or caffeine consumption may also be a factor – contributing to added stress for the adrenals and depletions in zinc and the B vitamins. This can contribute to lowered serotonin and a need for a higher dose of tryptophan.

Now imagine if it’s just before her period and she adds collagen to her diet and she also eats out and gets zapped by gluten. Triple whammy for this woman!

And she goes to a party and happens to indulge in cocktails or wine, and then goes on a binge at the dessert table, followed by a few cups of coffee (or even one dessert and one cup of coffee).

A food-mood log really helps you figure things out. And then, if need be, increase and decrease tryptophan accordingly. And track again and address the dietary issues.

Parasites and other gut issues

If she has a very pronounced shift in symptoms for 4-5 days around a full moon each month – more severe insomnia, more anxious, more depressed – I would want to check for parasites.

I would also want to check for other digestion issues like dysbiosis, SIBO (small intestinal bacterial overgrowth), candida and liver health as they may all be factors. With SIBO and candida, dietary slip-ups may make symptoms worse right after the slip-up, for example increased bloating making sleep and anxiety worse.

Using tryptophan sublingually/opened on the tongue may bypass some of the digestive/liver issues until they are resolved.

As mentioned above, if need be, increase and decrease tryptophan accordingly. And track again and address the underlying issues.

Other factors to rule out – thyroid, lithium, environmental factors and the product

Two other underlying root causes we always want to rule out when we see variable results using tryptophan (and any of the amino acids) are Hashimoto’s thyroiditis (because we can have variable thyroid results – sometimes hypo/low and sometimes hyper/high) and low levels of lithium (because this can affect the results we see with all the amino acids).

And we always check environmental factors like mold, EMFs and outside stresses. And look for infections like Lyme disease or EBV. If the basics are not unearthing the solution we continue to dig deeper and do a full functional medicine workup. And adjust the tryptophan as needed.

And finally the quality of the product is key. I find Lidtke Tryptophan to be better than many other brands. I’ve also had many clients switch to Lidtke tryptophan and see better results and often need a lower dose.

Resources if you are new to using tryptophan and the amino acids as supplements

If you are new to using the amino acids tryptophan/5-HTP and the other amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see the low serotonin symptoms here) and a brief overview here, Anxiety and targeted individual amino acid supplements: a summary.

If you suspect low serotonin or low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids so you are knowledgeable. And be sure to share it with the team you or your loved one is working with.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acid products that I use with my individual clients and those in my group programs.

I always appreciate good questions like this and hope this feedback has helped her and you too if you’ve experienced something like this (or if you do in the future). In case you’re wondering, this question was posted after someone tuned into my interview, “GABA & Tryptophan: Gut-Anxiety Connections” on the Anxiety Summit 5: Gut-Brain Axis.

Have you had a variable response to tryptophan (or 5-HTP) and can you relate to any of this?

What did you figure out to be the reason?

Feel free to ask your questions here too.

Mercury & gadolinium toxicity, iron overload, COVID-19: NBMI research update and potential applications

July 10, 2020 By Trudy Scott 15 Comments

Professor Boyd Haley set out to find a safe and non-toxic heavy metal chelator that would cross the blood-brain barrier, get inside the cells and bind mercury. The compound was initially sold as an antioxidant called OSR and is now called NBMI. In 2018 I wrote a blog about this – Mercury detox: NBMI as a safe and non-toxic heavy metal chelator. At the time NBMI was in phase 2 clinical trials. The blog was a popular one then and still gets many comments and requests for updates. Today I’m sharing some updates on progress, new studies and proposed new applications. I still find NBMI intriguing and look forward to it being readily available once the studies are completed.

The recent newsletter from EmeraMed, reports that their projects are all running according to plan (despite coronavirus setbacks) and “producing the anticipated positive results necessary to bring our drug to market. When we complete the studies requested last year by the FDA, EmeraMed will file a new drug application (NDA), which then starts the FDA approval process.”

Studies on metal binding have shown that NBMI is strongly attracted to mercury, arsenic, lead, cadmium, uranium, gadolinium [used as a contrast agent in MRIs] and free iron and copper.

EmeraMed are expanding the clinical trials to look at other disorders that NBMI can potentially improve. These updates were shared in the newsletter:

The Colombian drug regulatory agency INVIMA approved a trial for mercury intoxication in May 2020:

…mercury intoxication and kidney disease are a serious life-threatening intractable condition and prominent in Colombia

…mercury from fish in the Santa Margareta river is one potential source for kidney injury leading to dialysis treatment. It will be a double-blind placebo controlled pivotal study, the participants health and results will be carefully monitored.

The treatment will be much longer than our earlier trials with gold miners and will look at numerous physiological parameters.

There are two pilot studies on iron overload in Europe:

Excess iron causes many devastating disorders, some lethal. Atypical Parkinson, an always fatal disease, is partially finished.

We expect to receive an interim report by July 2020 on a Thalassemia study that shows a highly significant benefit from NBMI. 8 out of 8 improved without any reported drug induce toxic side effects. “Impressive” in the words of one reviewer.

A potential use for COVID-19 based on NBMI increasing glutathione levels:

The mechanism of action is based on the ability of Emeramide to: 1; enter cells and cross the blood brain barrier, 2; scavenge and remove existing hydroxyl free radicals lowering oxidative stress and 3; chelate into non-reactive and non-toxic complexes several toxic metals and most importantly Fe2+ a redox metal that has been proposed to be displaced from hemoglobin by the COVID-19 infection.

We know NBMI would help because viruses need to release free iron to be able to reproduce. That iron causes oxidative stress possibly leading to a cytokine storm.

Another potential application is environmental clean-up of rivers, lakes and streams:

Arsenic (As) in drinking water is a well-recognized problem but since it is very difficult to remove, EPA maximum drinking water standard allows drinking water to have arsenic levels that cause significant amounts of bladder and lung cancers.

And one more potential application is the improved “treatment of waste-water sewer sludge to remove mercury or other toxic metals before it is spread on farms.”

Here is the mercury feasibility trial mentioned in the newsletter: Efficacy of N,N’bis-(2-mercaptoethyl) Isophthalamide on Mercury Intoxication: A Randomized Controlled Trial, where NBMI was given to 36 gold miners with high levels of mercury in their urine:

Although this study was designed with a small sample size to test for feasibility, the gained results with 300 mg NBMI already showed an effect on physical fatigue with statistical significance and there were indications to positive effects on other symptoms, like sleeping problems.

The newsletter link above has information about which countries are allowing early access. Please contact the company directly rather than ask me about how to obtain the product as I am simply sharing what they have shared with me. I also encourage you to sign up for EmeraMed’s newsletter so you can keep up to date with progress and access information.

I find it intriguing and look forward to it being readily available once the studies are completed.

Please share if you used the original OSR product with any success or if you have managed to obtain NBMI and trial it?

And feel free to post your questions for Professor Boyd Haley. I’m hoping to have him speak on Anxiety Summit 6: Toxins/Meds/Infections.

Food Fix by Dr. Mark Hyman – my review

February 27, 2020 By Trudy Scott 4 Comments

Dr. Mark Hyman has a brilliant new book called called Food Fix: How to Save Our Health, Our Economy, Our Communities, and Our Planet – One Bite at a Time and his big bold message is that: “We need to change the food system to change the world.” It is an issue that is seriously overlooked and he wants to change this.

Watch this short video clip to hear it from Dr. Hyman himself.

Here are some of the key messages from Food Fix

If we don’t change the food system, we’re going to spend $95 trillion dollars on chronic disease – heart disease, obesity, type 2 diabetes, cancer, and dementia – over the next 35 years.

Big food spends a lot of money in Washington to keep us fat and sick.

The food industry preys on our most vulnerable citizens – children.

According to the American Psychological Association, children under the age of 8 don’t instinctively recognize the difference between TV Commercials and programs, which makes them particularly vulnerable.

Big Food buys partnerships with public schools.

Minorities are also targeted by the food industry.

Researchers at the University of Connecticut found that junk food companies spend the most on ads that target African Americans and Spanish speakers. Guess which products were most heavily advertised toward minorities—Gatorade, Pop Tarts, Twix Candy Bar, Cinnamon Toast Crunch Cereal, and Tyson Frozen Entrees

The worse the nutritional profile the more heavily the products were promoted through advertising.

Where are the broccoli ads?

These findings, the researchers noted, “highlight important disparities in the food and beverage industry’s heavy marketing of unhealthy foods to Hispanic and black youth, and the corresponding lack of promotion of healthier options.”

Bad food is making us anxious, depressed, and is messing with our brains. I’m thrilled that Dr. Hyman highlights how nutritional medicine is a key to mental health and psychiatry. Here are some snippets :

Studies show that adults with many types of mental health issues and children with ADHD have very low levels of antioxidants (which come from fruits and vegetables), such as the fifty-six-year-old man with lifelong crippling depression who improved by cleaning up his diet and taking a cocktail of B vitamins. I remember one man who presented with severe panic attacks every afternoon. Turned out he was eating a diet very high in sugar and starch and had wild swings in his blood sugar, which triggered the anxiety. When he cut out sugar and starch, his anxiety and panic attacks vanished. These stories are not anomalies. They are predictable results from applying nutritional medicine.

In recent years, major medical journals have clearly shown the link between nutrition and mental health. The Lancet Psychiatry, a top medical journal, maps out just how nutritional medicine is a key to mental health and psychiatry. Overall diet quality, high sugar loads, and rampant nutritional deficiencies (including omega‑3 fats, zinc, magnesium, vitamin D, and B vitamins) all drive mental illness. In other words, the culprit is once again the American and increasingly global industrial diet. We have discussed the costs of obesity and chronic disease, but most don’t connect mental illness to the costs of chronic disease. In fact, the cost of mental illness to the economic burden is far greater than the costs of heart disease, diabetes, and cancer.

Population studies have found that more fruits and vegetables and less french fries, fast food, and sugar are associated with a lower prevalence of mental illness, and that junk food creates moderate to severe psychological distress. The good news is that interventional studies have shown that treatment of mental illness with diet works well (especially since most medications for mental illness don’t work that well, despite being the second biggest category of drugs sold).

And here are a few of the many solutions proposed in the book:

Support regenerative agriculture and sustainable food.

Stop purchasing franken-foods:

Today 60% of our diet is ultra-processed food made from commodity crops—corn, soy, and wheat—that’s turned into various sizes, shapes, and colors from the raw materials—high fructose corn syrup, white flour, and refined soybean oil. When you vote with your dollars and your fork to stay away from these foods, you send a message to big food to stop subsidizing commodity crops and grow more fruits and vegetables!

End food waste:

Buy only what you need. If food may go bad soon, make a soup or stew. Get a compost bucket for your kitchen. Start a compost pile in your backyard, or buy an in-home composter. Use it in your garden or donate it to someone who has a garden.

Be an activist and teach your family why food matters.

Address food deserts and food swamps in African American communities, and recognize that this is:

“food apartheid,” an embedded social and political form of discrimination.

Here is the official book blurb:

Help to transform the planet in crisis with this indispensable guide to healthy, ethical, and economically sustainable food from #1 New York Times bestselling author Mark Hyman, MD.

Food is our most powerful tool to reverse the global epidemic of chronic disease, heal the environment, reform politics, and revive economies. What we eat has tremendous implications not just for our waistlines, but also for the planet, society, and the global economy. What we do to our bodies, we do to the planet; and what we do to the planet, we do to our bodies.

In Food Fix, Mark Hyman explains how our food and agriculture policies are corrupted by money and lobbies that drive our biggest global crises: the spread of obesity and food-related chronic disease, climate change, poverty, violence, educational achievement gaps, and more.

Pairing the latest developments in nutritional and environmental science with an unflinching look at the dark realities of the global food system and the policies that make it possible, Food Fix is a hard-hitting manifesto that will change the way you think about – and eat – food forever, and will provide solutions for citizens, businesses, and policy makers to create a healthier world, society, and planet.

I love that Dr. Hyman says he is left with a sense of hope and possibility after writing this book … “understanding the problems and challenges we face sets the foundations for the solutions.”

Wise words indeed! This book is much-needed, brilliant, eye-opening and shocking at times, but hopeful and solution-based.

You can get your copy of Food Fix here (my Amazon link) and find additional information and resources on the official book site here.

Mitochondrial Dysfunction in Anxiety with Tara Hunkin on The Anxiety Summit 5

October 18, 2019 By Trudy Scott 2 Comments

Tara Hunkin, NTP, CGP, RWP is one my guest experts on The Anxiety Summit 5: Gut-Brain Axis and our topic is: Mitochondrial Dysfunction in Anxiety. In this interview you’ll learn:

The role of mitochondria in the gut, brain and anxiety
Causes (such as medications and environmental toxins), testing, and signs and symptoms of mitochondrial dysfunction
Healing nutrients: Carnitine, COQ10, folinic acid, meal timing (as well as antioxidants and many other nutrients such as PQQ)

Tara starts with an overview of mitochondria, the energy powerhouses of our bodies and why they are so important in both physical and mental health.

You can hear some of this background information in this short in-person interview we did in San Diego recently.

(Note: The dates for the 2021 Anxiety Summit 5 is November 8-14, 2021)

You’ll also hear Tara share about this new bidirectional relationship that has been identified between anxiety and mitochondrial dysfunction. One of the papers she is referring to is this 2019 review paper: Anxiety and Brain Mitochondria: A Bidirectional Crosstalk. Here are the highlights:

Despite the established link between mitochondrial dysfunction and various psychiatric disorders, the contribution of mitochondria in anxiety disorders has not been extensively addressed.
Mitochondria are emerging as modulators of anxiety-related behavior, as evidenced both in animal and human studies.
There is a bidirectional link between mitochondria and anxiety. Mitochondrial, energy metabolism, and oxidative stress alterations are observed in high anxiety; conversely, changes in mitochondrial function can lead to heightened anxiety.

Tara shares how important the mitochondria are when it comes to digestion and gut health too:

the liver is heavily mitochondrial-dense and is needed to help eliminate toxins we are exposed to (toxins that affect our mitochondria and increase anxiety)
the mitochondria are also important when it comes to digestion – the lining of digestive tract (the epithelial cells of the microvilli) contain large numbers of mitochondria

The authors also highlight that “Pharmacological manipulation of mitochondria may be a potential therapeutic approach to relieve high anxiety symptoms.” One of the objectives of this summit is to highlight non-pharmacological approaches and Tara does exactly this in our interview.

She covers both lifestyle and nutritional approaches for addressing mitochondrial dysfunction (acetyl-l-carnitine, glutathione, antioxidants, coenzyme Q10, folinic acid and many more).

I also mention two other interviews on the summit where we talk about nutrients that also support mitochondrial function: PQQ (pyrroloquinoline quinone) and TUDCA (tauroursodeoxycholic acid).

Be sure to listen to these interviews for more about these two nutrients:

Jay Davidson, DC, PScD: Parasites, Anxiety and TUDCA for Your Liver
Michael Murray, ND: PQQ for Stress, Sleep, Mitochondria and Gut Health

We also discuss testing and all the environmental factors that impact the mitochondria including medications such as risperidone/risperdal (and antipsychotic medication), valproic acid (used for seizures), fluoroquinolone antibiotics like Cipro (and others) and also benzodiazepines (the commonly prescribed anti-anxiety medications).

You can listen to each of the interviews (and get transcripts) by purchasing The Anxiety Summit 5: Gut-Brain Axis.

If you’d like to give feedback or ask a question, please post in the comments section. I’d love to hear from you once you’ve listened in.

If you’d like to give feedback or ask a question, please post in the comments section at the bottom.

I’d love to hear from you once you’ve listened in to this interview and the others.