Tryptophan

GABA takes some of the anxiety edge away and now I want to add tryptophan: how do I do this?

January 13, 2017 By Trudy Scott 23 Comments

GABA and tryptophan are both calming amino acids with GABA helping more with physical anxiety, tension-in-the-body type of anxiety and tryptophan with anxiety-in-the-head, worrying and ruminations. Many of my clients do really well with both but I like to have them use one at a time to really make sure they are seeing all the benefits before adding the next one.

I recently received this excellent question on one of the blogs about serotonin support: she’s doing better on the GABA and now wants to add tryptophan:

I have started with Source Naturals Gaba Calm 125 mg, 2 on awakening and two in mid afternoon, and 2 Gaba Relaxer at bedtime. It has taken some anxiety edge away from me, but I still feel some anxiety on and off, not so severe as before. I used to feel very anxious on awakening. I want to improve more. to-day, I ordered Lidtke L-trytophan 500mg and am expecting to receive it in a week. I plan to take 2 Gaba Calm on awakening and 2 in mid afternoon, then add one 500mg trytophan mid afternoon and one 500 mg trytophan at bed time. Is this a good plan? or shall I have 2 Gaba Calm on awakening, 2 trytophan mid afternoon and 2 trytophan bedtime?

I love getting questions on the blog and make sure each one gets answered. However I can’t ever offer specific advice via the blog – you have to be a client for me to be able to do that. But because this is an excellent question I’d like to share some of what I shared with her in the hope it will help you (or your patients/clients) too.

First off I am so pleased to hear the Source Naturals GABA Calm and Country Life GABA Relaxer (a very nice combination of GABA, glycine, taurine, inositol, niacinamide and vitamin B6) has taken some of the anxiety edge away for her!

Here is my answer for her – about what I’d do next if I was working with her one-on-one:

There is also no specific formula to be followed because each person is different and when I’m working with someone we’re figuring out what is working and why and adjusting accordingly. If something is working we continue with that until no more benefits are seen.

I would say this – ask yourself what low GABA anxiety symptoms (this is the physical anxiety) have improved with the GABA and how much (rate each one before – out of 10; and what are they now – out of 10). From your question it sounds like they could improve more – so if we were working together I’d continue to increase GABA before adding something new.

Then once that has been done and we have the ideal amount I’d then check what low serotonin symptoms my client has (these are the busy mind, ruminations type or worry anxiety). If she does have some of these symptoms, pick or two and do a trial with 1 x 500mg tryptophan opened on to the tongue (or less if she’s super sensitive). She rates the symptoms out of 10 before the tryptophan trial and then after the trial. Depending on how she responds on the trial, we’ll decide if she needs 1 or 2 each time. The bedtime dose also depends on how bad the insomnia is. We continue to increase as needed based on symptoms.

All the while we are starting to make other changes – like diet, eating for blood sugar balance, no caffeine, no sugar, looking for high cortisol, no gluten, looking at gut health and for other nutritional deficiencies.

I hope this helps you and makes sense. In summary these are the guidelines I use:

It’s best to do one amino acid at a time when starting out
Make sure you’ve increased an amino acid so you can experience it’s full benefits before adding another one
Start all amino acids based on your unique needs – the best way to determine this is to do a trial first
Adjust accordingly while keeping a log of symptoms (with before and after ratings) and supplement amounts

Here are some links to additional resources related to the above:

The amino acid questionnaire to help you figure out which anxiety type you have: low GABA or low serotonin
How to do an amino acid trial
Targeted individual amino acids: what do we really mean?
Anxiety and the amino acids: an overview
- In this blog I make the following recommendation: if you do not have my book The Antianxiety Food Solution, I highly recommend getting it and reading it before jumping in to taking amino acids
Here are the supplements I use with my clients

I’d love to hear your feedback on your low GABA and/or low serotonin symptoms and the before rating (from 1 to 10) and the after rating (from 1 to 10) once you’re taking the related amino acid.

And please let me know if it’s helpful to read a real life question and my response.

I am on 5-HTP for anxiety and I am wondering about trying tryptophan instead

December 16, 2016 By Trudy Scott 74 Comments

Both 5-HTP and tryptophan help to boost serotonin levels so you can feel happy, calm, sleep well and not crave carbs. I typically have my clients who have low serotonin symptoms start with a trial of tryptophan because it I see such excellent results with this amino acid. That being said, some people simply do better on one versus the other and you may do better with 5-HTP. If you have low serotonin symptoms and are using either of these amino acids and not getting the expected results, it’s worth considering a change.

Here is a question I recently received on the blog. It’s something I’m commonly asked about and something I deal with often when working one-on-one with clients:

I am on 5-HTP (400 mg) [for anxiety]. I am wondering about trying tryptophan instead. What is the best (safest) way to make the switch? What is the starting dose you usually suggest? I am tapering off SSRIs so I know my serotonin reserves are low.

Here are some of the reasons you may want to consider switching and doing a trial of tryptophan

the 5-HTP is not working as you would expect for your anxiety or depression, or other low serotonin symptoms like PMS, insomnia, afternoon and evening carb cravings, negative self-talk, perfectionism, worry in the head and ruminations, and even anger issues or irritability (here is the complete questionnaire)
the 5-HTP is causing digestive issues
you have done an adrenal saliva test and discovered you have high cortisol. If you feel wired-tired I like to use tryptophan because 5-HTP has been shown to raise cortisol levels

Depending on how severe your symptoms are I would have you slowly replace one with the other, keeping in mind that 50mg 5-HTP is roughly equivalent to 500mg tryptophan.

In this particular case she was taking 400 mg 5-HTP and was surprised to hear that she may now need 2000 mg tryptophan, saying “that seems like a lot!”

Here is my feedback:

2000mg tryptophan isn’t too much if you have low serotonin symptoms and need it. If we were working together I would have her start with a trial of 500mg which is the typical starting amount and increase based on her response. If 500mg helps some symptoms but doesn’t give complete resolution of symptoms then I’d have her try 1000mg and monitor symptoms, and then go up to 1500mg and even 2000mg.

She may respond better to tryptophan and may only need 500mg or 1000mg or she may in fact need the full 2000mg.

She is currently taking an SSRI, so I would assume her doctor already knows she has been using 5-HTP and knows her plans to switch, giving approval and monitoring for possible serotonin syndrome. She would also take the tryptophan at least 6 hours from the SSRI.

Here is additional information on SSRI tapering while using amino acids.

Obviously a similar approach could be used to switch from tryptophan to 5-HTP.

I also only ever recommend the Lidtke brand of tryptophan. You can find this and the other amino acids I use with my clients here.

Have you switched from 5-HTP to tryptophan and seen added benefits?

Have you switched from tryptophan to 5-HTP and seen added benefits?

If you’re a practitioner please share if you’ve used this approach successfully.

Sleep improvement: Oral intake of GABA and Apocynum venetum leaf extract

July 8, 2016 By Trudy Scott 17 Comments

sleep-improvement

I’ve blogged about the Sleep promoting effects of combined GABA and 5-HTP. There is another combination of nutrients that has been shown to help with sleep: GABA and the herb Apocynum venetum leaf extract.

In this 2015 paper: The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract

The electroencephalogram (EEG) test revealed that oral administration of GABA (100 mg) and [Apocynum venetum Leaf Extract] AVLE (50 mg) had beneficial effects on sleep.

In this study they found that GABA helps people to fall asleep quickly and Apocynum venetum Leaf Extract induces deep sleep, and that they work well when taken together.

The authors conclude that both GABA and Apocynum venetum leaf extract:

can be regarded as safe and appropriate for daily intake in order to improve the quality of sleep.

Earlier this year I heard Dr. Peter Bongiorno present at the Integrative Healthcare Symposium and one of the herbs he covered was Apocynum venetum leaf extract for depression. Since this was new to me, I invited him to share about this herb on the recent Anxiety Summit: Serotonin and anxiety: tryptophan, 5-HTP, serotonin syndrome and medication tapers

I also briefly mentioned the above GABA/Apocynum venetum leaf extract study in my talk on the recent Anxiety Summit – GABA: Blood brain barrier controversy, concerns, best forms and how to do a trial for eliminating anxiety

I find that many of my clients with anxiety also have sleep problems and GABA is often helpful if their sleep issues are related to low GABA levels, often manifesting as physical tension.

One of the signs of low serotonin, in addition to anxiety and worry, is insomnia and I find tryptophan (and sometimes 5-HTP) to be very helpful for many clients too. I’ll often have someone use both GABA and tryptophan (or GABA and 5-HTP) and the combination seems to be a good one.

I have not yet used Apocynum venetum leaf extract alone with clients or in combination with GABA and look forward to learning more. Have you have tried it alone or in combination with GABA? Have you used it with clients?

Tryptophan for PMS: premenstrual dysphoria, mood swings, tension, and irritability

July 1, 2016 By Trudy Scott 69 Comments

In a study published in 1999, A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria, tryptophan was found to reduce symptoms of PMS when used in the luteal phase or second half of the cycle (i.e. after ovulation):

37 patients with premenstrual dysphoric disorder were treated with L-tryptophan 6 g per day, and 34 were given placebo. The treatments were administered under double-blind conditions for 17 days, from the time of ovulation to the third day of menstruation, during three consecutive menstrual cycles.

They looked at dysphoria, which is defined as a state of unease or generalized dissatisfaction with life, plus mood swings, tension (and anxiety), and irritability and they found a 34.5% reduction of symptoms with tryptophan compared to 10.4% with placebo.

The paper concludes:

that these results suggest that increasing serotonin synthesis during the late luteal phase of the menstrual cycle has a beneficial effect in patients with premenstrual dysphoric disorder.

Let me share what I see with the women with PMS that I work with:

This is very typical when I’m working with someone with PMS and anxiety and other mood symptoms. It typically takes 2 to 3 cycles for an amino acid like tryptophan to have an impact on PMS itself. But it does typically start to work right away on the less severe anxiety and mood symptoms that may also be a factor during the rest of the month.
I don’t start with 6g per day of the tryptophan but rather have each person do the amino acid questionnaire, review the precautions and do a trial of tryptophan, increasing as needed to find the optimal amount for their needs (you can read more about this here on anxiety and the amino acid overview
We often find that adding GABA helps too, as this supports progesterone production
Many anxious women I work with also have pyroluria or signs of low zinc and low vitamin B6 and adding these nutrients, together with evening primrose oil, provide additional hormonal support (and help with the social anxiety).
Other factors to consider with PMS: low total cholesterol (as cholesterol is needed to make hormones), gluten issues, adrenal function and blood sugar control, gut health and the microbiome, and liver support
And finally, we can’t forget diet and need to switch to eating a real whole foods diet free from sugar, gluten and caffeine. Coffee and chocolate in the second half of the cycle can be especially problematic for many women

Together with the tryptophan and the above approaches (if needed as we are all so different), it’s not unreasonable to get the reduction of symptoms from 34.5% (as seen with the tryptophan) down to 100%. It breaks my heart when I hear women think they have to live with PMS symptoms when they don’t have to!

Additional resources when you are new to using tryptophan, GABA, and other amino acids as supplements

As always, I use the symptoms questionnaire to figure out if low serotonin or low GABA or other neurotransmitter imbalances may be an issue.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control (this is covered in an entire chapter too), sugar cravings, anxiety and mood issues.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Wrapping up and your feedback

Have you used tryptophan for PMS? Do you take it all month or just in the 2nd half of your cycle? What about other changes that have helped: GABA or liver support or quitting caffeine? Or something else? Please share.

Tryptophan for anxiety, sleep and mood: in Put Anxiety Behind You

May 6, 2016 By Trudy Scott 98 Comments

Tryptophan is an amino acid I use with clients all the time. If you have the low serotonin symptoms of anxiety, worry, depression, insomnia, PMS, TMJ, anger issues, winter blues and afternoon/evening cravings, tryptophan can provide relief very quickly, provided you use a quality tryptophan product and find the right amount for your unique needs. I do a trial of each amino acid with my clients.

Dr. Peter Bongiorno, ND, a doctor of naturopathic medicine, also uses tryptophan with his patients. Here is an excerpt on tryptophan from his newest book Put Anxiety Behind You: The Complete Drug-Free Program:

Tryptophan (sometimes referred to as L-tryptophan) is a naturally derived amino acid that serves as a precursor to the neurotransmitter serotonin, which is needed to help you stay asleep. Low levels of tryptophan contribute to generalized anxiety and panic attacks. Back in the early 1990s, a laboratory I was associated with at Yale University performed “tryptophan depletion studies” and which volunteers who were already prone to anxiety were put on a tryptophan-free diet. Within days, these people were extremely anxious, panicky and unstable – and they had lots of trouble staying asleep.

I usually give people 500 – 1,000 mg of tryptophan at bedtime, but I may dose up to 2,500 mg. Take tryptophan at bedtime with a slice of simple carbohydrate (like an apple slice) – the carbohydrate will increase insulin levels and insulin will promote tryptophan absorption in the brain. In my clinic I use a supplement called Tryptophan Calmplete, which includes B vitamins.

Although most conventional psychiatrists are afraid to mix natural medicines like tryptophan with conventional medications studies suggest that they can be safely combined. One eight-week randomized controlled trial of thirty patients with major depression combined 20 mg of Prozac (an SSRI medication) with 2,000 mg of tryptophan as daily treatment for major depressive disorder. This study demonstrated that combining tryptophan and an SSRI improved mood and helped patients stay asleep.

If you look up tryptophan on websites like WebMD, they are going to tell you that tryptophan is unsafe. The reason for this is because in the early 1990s there was an incident of Eosinophilia Myalgia Syndrome, a condition contracted by thirty people who most unfortunately got sick (and some died) after ingesting tryptophan supplements. This tragic event occurred because the company making the supplement had no quality controls, and allowed the introduction of bacteria. These deaths had nothing to do with tryptophan itself. My sense is that the folks behind conventional websites WebMD, who should be doing their homework, let these ideas persist on purpose. The drug companies who advertise with these websites then benefit from continuing the misinformation. I have taken tryptophan myself, have used it with family members and countless patients with absolutely no problem save for the side benefit of better sleep and mood.

This book is an excellent resource for anxiety, where addressing nutritional imbalances with a supplement such as tryptophan is part of the bigger picture of addressing sleep, doing thought work and mind-body work, balancing hormones and blood sugar, exercising, adopting a healthy real foods diet, and making sure you have a healthy digestive system.

He uses the analogy of a stool – when one of the legs or supports is weak, your health suffers.

put-anxiety-behind-you-fig1

I’m a research-geek and love to be able to look at the studies so my only negative comment about the book is that all the studies mentioned in the text are not listed in the references and studies that are listed in the references are not numbered so they can be easily found in the text.

His other book Holistic Solutions for Anxiety and Depression: Combining Natural Remedies with Conventional Care is also excellent and is geared to therapists and other practitioners. You can read my review of that book here.

I had the pleasure of interviewing Dr. Bongiorno on The Anxiety Summit (season 3) – our topic: Serotonin and Anxiety, Happiness, Digestion and our Hormones. And I’m excited to share that he’ll be speaking on Season 4 of the Anxiety Summit. We’ll be taking a deeper dive into serotonin and tryptophan.

I also had the pleasure of meeting Dr. Bongiorno in person and hearing him present at the New York City Integrative Healthcare Symposium earlier this year.

peter-trudy

Dr. Bongiorno is co-director of Inner Source Natural Health and Acupuncture in New York City. President of the New York Association of Naturopathic Physicians, he is a contributor to numerous blogs and online magazines, including DrOz.com and Sharecare.com, and is regularly interviewed as a natural medicine expert on national television and radio.

Dr. Bongiorno has been kind enough to offer a copy of Put Anxiety Behind You: The Complete Drug-Free Program as a giveaway. We’ll do a drawing and select one lucky reader and announce the winner next Friday. If you’d like to be entered in to the drawing simply comment below and share:

~~why you’d like to win the book~~
~~if you’ve used tryptophan and what results you saw/see~~
~~which section you’re most excited about reading and why (just go to the Amazon preview via this link and check out the table of contents and sections of the book)~~
~~which holistic approaches you already use personally or if you’re a practitioner, what you have used with your anxious patients/clients~~

5/12/16 UPDATE: Thanks for participating and commenting – the winner is Liz. We’ll contact you to get a mailing address and get a copy of the book to you! Enjoy it!

If you missed out I encourage you to still check out the table of contents (with the look inside Amazon feature) and get the book if it feels like a fit for you. Check out the comments below to be inspired further.

Please share your feedback (and questions you may have) in the comments section below.

Tryptophan, red meat and baby steps for anxiety: the Brain Summit

May 1, 2016 By Trudy Scott 18 Comments

Just a quick reminder that the Brain Summit starts tomorrow, Monday, May 2nd.

brainsummit-trudy

Here are some snippets from my anxiety interview with host Erin Matlock. We started out talking about diet and grass-fed red meat and why it’s so beneficial if you have anxiety (and other mood problems):

…there’s a lot of research showing now that [a Western diet] diet is not good for so many conditions, and mental health is now coming into the research. And we know this, but to see it in the research is really beneficial. Dr. Felice Jacka did a great study in Australia that was one of the first studies that looked at anxiety and depression in women and found that the Western diet was associated with a higher risk for anxiety and depression. And this whole foods, traditional diet, that actually included grass-fed red meat, was more beneficial for anxiety and depression. And in her thesis, they actually looked at red meat thinking that they would find that red meat was actually detrimental. And, lo and behold, they found that grass-fed red meat was one of the most important predictors for good mental health. So a lot of people say, “I don’t eat red meat any more. I’m being healthy.” And in actual fact, not eating it is doing them harm.

So red meat is wonderful! And it needs to be grass fed because then you’re getting the good levels of the Omega-3s. The Omega-3 three profile of grass fed red meat is very similar to what you would find in salmon. Obviously, fish is great, so while fish like salmon or sardines are great as well, the reason I like the red meat is it’s something that most people enjoy eating. And as well as the Omega-3s, we’re getting the iron, and iron is a co-factor for making serotonin and making GABA, and it’s needed for energy and so many other functions in the body.

It’s also got zinc, and zinc is a common deficiency, way more common than we realize. And when you are anxious, you may have high copper level, and low zinc level. So getting those zinc levels up will push the copper down, and that can help with your anxiety, as well.

We also had a long discussion on serotonin and tryptophan/5-HTP:

…we often associate serotonin with depression. And a lot of people don’t realize that it’s very closely tied to anxiety, as well. So we’ve got two types of anxiety when it comes to the brain chemicals. One is the low-serotonin type, and this is the anxiety in the head, where you’ve got the ruminating thoughts, and the busy mind, and the negative self-talk, and just this monkey mind that you can’t switch off — this worry, and sort of reprocessing things. And then we have the low-GABA kind of anxiety, where it’s in your physical body and you’re feeling stiff and tense, and you can feel it in your body, and you may feel it in your gut….

I have people do a questionnaire, and depending on how you score on that questionnaire, that’s a clue as to whether serotonin may be a factor. So all of those symptoms I’ve just mentioned, you would rate yourself on a scale of one to ten. And then I use individual, targeted amino acids. So it’s a supplement, and the other things that obviously have an impact are food, and diet, and everything we just talked about. Getting exercise, getting outside in the light, all of those are factors.

But for quick, immediate results, and pretty profound results – people just say to me, “Could this really be happening so quickly?” that’s how quickly we get results, you know, within 30 seconds to two minutes they’re getting results – is to use these individual amino acids as supplements. And the reason they’re called “targeted” is because it’s targeted to your unique needs. Like when you do the questionnaire and it says, yes, you need some serotonin support, and then you would use either tryptophan or 5-HTP as a supplement. And again, targeted, because you need it, but also targeted to your unique biochemistry.

There’s a standard starting dose for tryptophan, which is 500 mg, while 5-HTP is 50 mg.

Be sure to tune into the interview with Debbie Hampton. She is the survivor of an acquired brain injury (from a pill overdose when trying to commit suicide) and the author of the upcoming book, Sex, Suicide, and Serotonin. Her story and resilience is inspiring! Here is Debbie’s wonderful answer to Erin’s question: “What advice would you give to someone who feels like it’s too late to do what they want to do? I’m already so deep in, there’s no way that I could possibly have the life that I wanted or do the work that I really wanted to do.”

debbie-hampton

It’s never too late. And those limitations, you’re putting on yourself. Those limitations are in your mind. If you think you can’t, and you think it’s too late, then it is. You’ve got to change your mind first and if your mind thinks you can, you’re halfway there.

My advice would be to start small … I’m not big on long-term plans. I’m big on a long-term bigger goal. But what you’ve got to do is you’ve got to take a little step in the right direction towards that goal, and when you get there, you look around and you say, “Okay, what is my next best step?” And when you get to that next step, there may be opportunities that you can see that you couldn’t even see back here.

So you’ve got to take it one step at a time and get there and assess your opportunities. And then figure out the next best step, and then get there and figure out the next one. And it may be a zigzag path, and you may even have to go back sometimes, regress, but as long as you just keep moving forward and keep positive momentum and positive thoughts and be your own cheerleader, and encourager, and supporter— be your own friend—that is the most important thing.

I could not agree more – there is an answer, you can do whatever you set out to do and just take baby steps!

You can register for the Brain Summit here:
http://www.brainsummit.com?orid=45505&opid=12