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amino acid questionnaire

Oral GABA supplementation allows better prioritizing of planned actions: new research

September 4, 2015 By Trudy Scott 41 Comments

gabaexamples
Prothera 500mg GABA and Source Naturals GABA Calm (with 125mg GABA) are examples of GABA products I use with my clients

A paper recently published in Scientific Reports: γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial provide the first evidence for a possible causal role of the GABA-ergic system in modulating performance in action cascading:

In order to accomplish a task goal, real-life environments require us to develop different action control strategies in order to rapidly react to fast-moving visual and auditory stimuli. When engaging in complex scenarios, it is essential to prioritise and cascade different actions.

A good example of when we may do something like this is driving a car in busy traffic:

  • you are fast-moving
  • there are noises all around you – for example: wind, hooting horns, big trucks, rain and water, passengers talking etc.
  • you are seeing things all around you – for example: the steering wheel, the speedometer, the other cars, the road, road signs, billboards, the scenery, your passengers etc.

The findings of this study, which involved the administration of 800 mg of synthetic GABA (compared to placebo), found that study participants were better able to prioritize planned actions (for example: make safe driving decisions).

I’m really pleased the study addressed the GABA-blood brain barrier controversy:

In the literature, there are controversial findings about GABA entering the brain through the blood brain barrier (BBB). The BBB is a tightly sealed layer of cerebral endothelial cells that form continuous tight junctions and prevent most solutes from entering the brain on the basis of size, charge, and lipid solubility. However, as pointed out by Shyamaladevi and colleagues, recent studies have demonstrated that the BBB is much more dynamic than assumed in the past, and some passage of solutes can occur by transcytosis, carrier-mediated transport, or simple diffusion of hydrophobic substances

While there is some evidence in favor of only a limited penetration of GABA into the brain, a more recent study with rats has shown that the administration of GABA alone increased brain GABA concentration, when compared to untreated rats.

In addition, the syntethic GABA-like agent gabapentin, which mimics the chemical structure of GABA, leads to an overall increase in central GABA levels and a recent study using 7-T MRS reported an increase in GABA concentration in the visual cortex of healthy participants after gabapentin administration.

Michael Jurgelewicz, DC, DACBN, DCBCN wrote this Designs for Health article about the study: GABA supplementation may help improve ability of prioritizing planned actions, mentioning two possible mechanisms of action as to how GABA supplementation may improve prioritizing planned actions as well as reducing anxiety:

Oral GABA supplementation can act directly on the CNS in a peripheral aspect through the gut. There is definitely a gut-brain relationship between nutrition and the gut microbiome and how they support brain health and function. The gut and brain communicate through the nervous system, immune system, and hormones.

In addition, the hypothalamus (emotional neuroendocrine control center of the brain) is outside and not protected by the blood brain barrier, so these two factors can explain how GABA affects the CNS. It is clear in the research that GABA is helpful with anxiety, and there are many case studies which demonstrate its effectiveness.

Here are some comments from 3 different people on facebook, demonstrating GABA’s effectiveness:

GABA was huge for super tight neck and shoulders! Within 5 min of taking I experienced tremendous relief of muscles and anxiety too

I like True Calm for clients that can’t wind down at night too, it has GABA in it.

GABA, definitely. It’s really helped my tight upper back and neck to feel better.

If you’re looking for more GABA info, during season 2 of The Anxiety Summit, I talked about the BBB, the GABA challenge (which I’m not in favor of) and GABA-receptors in peripheral tissues: Targeted individual amino acids for eliminating anxiety: practical applications.

I would like to add that 800mg of GABA is a much higher dose than I have my clients start with. I have them start on 125mg (as part of Source Naturals GABA Calm) and go up from there. Enzymatic Therapy has a nice 250mg GABA product and I really like the Nutritional Fundamentals for Health GABA-T SAP which has GABA 300 mg and 150 mg l-Theanine 150 mg. The Prothera 500mg GABA is a good choice if you can tolerate higher amounts. Here are links to these and other brands I like. I don’t typically use pharmaGABA and am not a fan of phenibut.

The promising results of this randomised controlled trial show that oral GABA intake makes a difference and does have an impact on behavior. This is big news!

Here is the Amino Acid Questionnaire so you can see if you have low GABA symptoms. It seems we’re going to have to revise it and add “inability to handle complex planned tasks” and “poor prioritization skills.”

Have you noticed that you can handle complex planned tasks and are better at prioritization when you are taking GABA (or have taken it in the past)?   I can’t but wonder if it’s the overwhelm factor that is being removed/lessened when taking GABA?

If this all sounds a little overwhelming perhaps you are low in GABA? Stay tuned for the launch of The Amazing Aminos for Anxiety homestudy group program that will be starting later in September. This homestudy group program will provide guidance with using each of the targeted individual amino acids, including GABA.  You’re welcome to sign up here to be notified when we have details about the start date and more.

Filed Under: Amino Acids, GABA Tagged With: amino acid questionnaire

60+ Nutritional & Biochemical Causes of Anxiety

May 19, 2015 By Trudy Scott 42 Comments

puzzle pieces

I shared these 60+ Nutritional & Biochemical Causes of Anxiety on my closing call  of the The Anxiety Summit season 3.   I hope they will help you put the puzzle pieces together to resolve your anxiety.

The Foundational Causes from The Antianxiety Food Solution :

  1. Food – real whole food, organic (pesticides may be problematic), quality protein (grass-fed, wild, pastured), healthy fats; avoid junk/processed food with additives/colors/trans fats/GMOs
  2. Sugar – depletes zinc and magnesium and fills us up. We should not feel the need for treats/fruit should satisfy our desire for sweet
  3. Low blood sugar – breakfast/protein/healthy snacks/no coffee
  4. Caffeine/Coffee – even decaf coffee may be an issue. Coffee has high-levels of pesticides, affects blood sugar and affects hormones
  5. Tobacco – depletes key nutrients like zinc, vitamin C      
  6. alcohol – depletes key nutrients like zinc, vitamin C
  7. Food sensitivities – gluten (plus glyphosates/roundup affect serotonin/zinc etc), dairy, GAPs, grains
  8. Digestive system – low HCl
  9. Digestive system – Low good bacteria/probiotics
  10. Digestive system – other enzymes are low
  11. Digestive system – candida
  12. Digestive system – parasites
  13. Digestive system – leaky gut
  14. Digestive system – liver/gallbladder issues
  15. Digestive system – SIBO
  16. Brain chemicals/neurotransmitters: low GABA (covered in detail in season 4 of the Anxiety Summit) 
  17. Brain chemicals/neurotransmitters: low serotonin
  18. Brain chemicals/neurotransmitters: low endorphins
  19. Brain chemicals/neurotransmitters: low catecholamines (need for coffee/sugar) or high catecholamines. Gut health, what you eat, coffee, gluten all affect the brain chemicals
  20. Pyroluria/social anxiety – zinc, vitamin B6 and EPO (addressing this improves brain chemical imbalances and hormone imbalances)
  21. A need for zinc
  22. A need for vitamin B6
  23. A need for EPO
  24. Toxins/pesticides/plastics/BPA
  25. Medication side-effects/withdrawal (benzos are the worst)
  26. Sex hormones imbalances (especially low progesterone)
  27. Thyroid problems – hyperthyroid/Hashimoto’s thyroiditis can cause anxiety symptoms; low thyroid symptoms – amino acids are not as effective
  28. Adrenals issues: cortisol imbalance can affect how you handle stress, digestion, inflammation; high cortisol can have direct impact on anxiety levels
  29. Low total cholesterol (<150)
  30. Low levels of vitamin D, magnesium, vitamin C
  31. Low levels of vitamin B12
  32. Low levels of folate
  33. Low levels of iron (test ferritin)
  34. Not getting exercise
  35. Not working on stress-reduction (tai chi, meditation, guided imagery, yoga)
  36. Not getting out in nature
  37. Not getting at least 8 hours of sleep
[the above are all covered in great detail in my book  The Antianxiety Food Solution ]

Other possible nutritional/biochemical/physical causes of anxiety/depression

  1. Drug-induced nutrient deficiencies (for example: the birth control pill depletes vitamin B6, folate, magnesium)
  2. MVP (mitral valve prolapse) – it feel like the “heart is skipping a beat” (magnesium may help)
  3. Infections – strep can cause OCD/PANDAS/PANS. Also consider: H/Pylori, Lyme disease, clostridia
  4. Heavy metals like mercury or lead.  We covered mercury in season 2 – Your hidden mercury burden: A likely root cause of the other root causes of anxiety and mercury/lead detox in season 4 with Dr. John Dempster
  5. Anything that increases inflammation in the body (high CRP is a good clue)
  6. Herbicide/Roundup use in the home/garden
  7. Genetic polymorphisms – MTHFR, COMT, MAOA, GAD – Dr. Ben Lynch is an excellent resource and has shared his expertise on season 2 – Anxiety: Biochemical and genetic predispositionsand season 3 – How Methylfolate can make you Feel Worse and even Cause Anxiety
  8. Apolipoprotein E ?4 (ApoE ?4) gene polymorphism
  9. Other possible hormone issues: high prolactin, low oxytocin
  10. Histamine reaction to certain foods (Yasmina covers this in her interview in season 3: Histamine-containing Foods: their Role in Anxiety, Depression and Schizophrenia )
  11. Oxalates reaction (berries, leafy greens, nuts). A good resource is lowoxalateinfo
  12. SIBO and FODMAPs/fructose malabsorption (affects serotonin levels)
  13. Too much of some nutrients: fish oil, a B complex, tyrosine, folate
  14. Low lithium (impacts GABA levels)
  15. Copper toxicity i.e. high copper and low zinc
  16. EMFs, air pollution, noise pollution, cell phone use, smart meters
  17. Marijuana use – used recreationally or as medical marijuana (Dr. Hyla Cass covers this in season 4 of the Anxiety Summit – cognitive issues, anxiety, psychosis, schizophrenia, social anxiety)
  18. Toxic mold exposure (Dr. Jill Carnahan covers this in season 3)
  19. Fluoride exposure
  20. Poor mouth health
  21. Toxoplasma gondii
  22. Metals/chemicals/drugs in the tap water
  23. Low leptin (signals satiety/fullness) and high ghrelin
  24. Over-the counter drugs, inner ear issues/cochlear damage, light sensitivity (Sharon Heller shared Hidden Causes of Anxiety on season 2) 
  25. Physical pain (from an injury)
  26. Gas leaks
  27. Plastics/BPA
  28. Accutane, the acne drug can lead to psychiatric disorders in some people

May 14, 2016 updates after Season 4 of the Anxiety Summit:

   66. Leptin resistance, obesity, skinny-fat and high body fat % (Mike Mutzel covers this in season 4 – anxiety, inflammation, microbiome, PTSD, cortisol and HPA axis)

   67. Fluoroquinolone antibiotics (Lisa Bloomquist covers this in season 4 – anxiety, psychosis, connective tissue damage, mitochondrial impacts)

   68. Low histamine/histapenia/overmethylation or high histamine/histadelia/undermethylation – read more here and the season 4 interview with Dr. William Walsh

   69. Lack of community and social connection (James Maskell covers this in season 4)

Note: these causes do not include psychological or physical trauma or abuse (both past and current).

If the idea of 60+ causes feels too overwhelming and scary for you start with the basic food changes and look at the Amino Acids Mood Questionnaire from The Antianxiety Food Solution. GABA and serotonin support benefits most of my clients.  You can see how to do a trial here  and find the products I use with my clients here – such as tryptophan and GABA.

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here: www.theAnxietySummit.com

Missed this interview or can’t listen live? Or want this and the other great interviews for your learning library? Purchase the MP3s or MP3s + transcripts and listen when it suits you.

You can find your purchasing options here: Anxiety Summit Season 1, Anxiety Summit Season 2, and Anxiety Summit Season 3.

Filed Under: Amino Acids, Antianxiety, Food and mood, Gluten, Real whole food, The Anxiety Summit 3 Tagged With: amino acid questionnaire, anxiety, biochemical, nutritional, real whole food, the anxiety summit, Trudy Scott

The Anxiety Summit – 60+ Nutritional & Biochemical Causes of Anxiety and Recommended Supplements

May 19, 2015 By Trudy Scott 88 Comments

 

Trudy Scott, host of The Anxiety Summit, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution presents:

Closing call: 60+ Nutritional & Biochemical Causes of Anxiety and Recommended Supplements

  • 60+ Nutritional/biochemical causes of anxiety and associated solutions
  • 4 degrees/levels of anxiety I see and response to the 60+ causes
  • The unique ability of the body to heal
  • Testing I use with my clients and what tests I’d run if everyone had unlimited funds
  • My recommendations:  supplements
  • My message of hope

I mentioned the speaker blog posts.  You can access them all here: The Anxiety Summit Season 3: All the speakers and topics

I also referred back to speakers and topics from season 1 and 2 so here are those links:

The Anxiety Summit Season 2: All the speakers and topics

The Anxiety Summit: All the speakers and topics (this is summit 1)

If the idea of 60+ causes feels too overwhelming and scary for you here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution. Serotonin support in the form of tryptophan or 5-HTP may help

As Dr. Peter Bongiorno said in his interview: Serotonin and Anxiety, Happiness, Digestion and our Hormones

There can be multiple factors involved as to why someone has anxiety. How you’re going to work through these factors successfully is going to be very different for each person.

Here is the list of the 60+ Nutritional/biochemical causes of anxiety.  (Just click on this link to see all of them)

Here is the list of supplements: The Antianxiety Food Solution Amino Acid and Pyroluria Supplements (Just click on this link to see all of them)

Here is the: Nutritional testing for figuring out the root cause/s of your anxiety (Just click on this link to see all of them)

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here: www.theAnxietySummit.com

Missed this interview or can’t listen live? Or want this and the other great interviews for your learning library? Purchase the MP3s or MP3s + transcripts and listen when it suits you.

You can find your purchasing options here: Anxiety Summit Season 1, Anxiety Summit Season 2, and Anxiety Summit Season 3.

Filed Under: Amino Acids, Antianxiety, Food and mood, Gluten, Real whole food, The Anxiety Summit 3 Tagged With: amino acid questionnaire, anxiety, biochemical, nutritional, real whole food, supplements, the anxiety summit, Trudy Scott

Urinary neurotransmitter testing falls short

July 11, 2014 By Trudy Scott 37 Comments

lab

I am often asked about urinary neurotransmitter testing and often a new client will come in with results from a test she/he has had done. I would like to share my thoughts on this rather controversial subject and say that I am not a fan and do not ever use this test. Let’s take a deeper dive into this topic.

The question

Here is a question I received right after the Anxiety Summit:

I have had good results using urinary neurotransmitter testing and targeted amino acid therapy and bioidentical hormones. I am able to see if all levels are low, indicating low stomach acid. I am also able to see if histamine or glutamate are high, indicating food hypersensitivities. I also use the levels for balancing and replacing. I know that Julia Ross is opposed to testing. What is your opinion and what did your other speakers [on the Anxiety Summit] say about this topic?

This is my answer:
I am very pleased that this person sees good results using urinary neurotransmitter testing and targeted amino acid therapy.

Why I am not in favor of this testing

However, I am not in favor of this testing for a few reasons:

1) Julia Ross is not in favor of it and having worked with her in her clinic for 2 years I respect her professional opinion and the results she saw when urinary neurotransmitter results didn’t correlate with amino acid questionnaire and trials of amino acids. Julia wrote a great article on this topic for the Townsend Letter and you can access this via the anxiety summit blog for her interview

2) Since leaving the clinic and starting my own practice, I’ve worked with folks who come in with urinary neurotransmitter test results that don’t always with correlate with amino acid questionnaire and trials of the amino acids. But I will be the first to admit that I have not done a thorough analysis of where they haven’t correlated simply because it didn’t seem worth my time.

3) I have heard some rather unpleasant stories from people who have had the urinary neurotransmitter testing done and have been given supplement recommendations based on the results. I just received an email recently from someone who said this:

I was doing xyz’s program last year and the aminos recommended based on urine neurotransmitter testing nearly sent me over the edge with extreme anxiety, insomnia and panic attacks. He had me take 300mg 5-HTP and 3000mg tyrosine a day, based on test results.

We know that anyone can have a bad reaction to supplements. But let me comment on this example: 5-HTP can raise cortisol and be stimulating for some people so it’s not something I recommend for everyone with low serotonin symptoms; 3000mg tyrosine a day is not excessive (1-2 x 500mg , 3 times a day is often typical) BUT will be too much if you don’t need it and can cause anxiety and insomnia.

4) A 2011 paper by Marty Hinz “Validity of urinary monoamine assay sales under the spot baseline urinary neurotransmitter testing marketing model” states that

No peer-reviewed published original research exists which demonstrates that these assays are valid in the treatment of individual patients in the clinical setting.

Low stomach acid and food hypersensitivities?

I’d like to also comment on two other parts of this question:

  • “I am able to see if all levels are low, indicating low stomach acid.” I have not heard this correlation and would use other labs markers for low stomach acid – like total protein, globulin etc – and the person’s response to a HCl trial.
  • “I am also able to see if histamine or glutamate are high, indicating food hypersensitivities.” I have also not heard of this correlation and would use an IgG test and food elimination and challenge to help figure out if someone has food sensitivities.

What do other speakers think?

It was also asked what other speakers on the Anxiety Summit said about this topic:

  • Other than Julia Ross, the only person who mentioned urinary neurotransmitter testing briefly was Dr. Anna Cabeca and we didn’t go deeper into the topic.
  • I did email Dr. Kelly Brogan and she said

I actually don’t use them. Occasionally I do serum amino acid testing (ION panel) but don’t feel that the science is there to support urinary neurotransmitter testing and feel that the reductionism around amino acids and behavioral translation is not consistent with my perspective and not needed for the outcomes I get.

If you listened to our interview on the Anxiety Summit, you’ll remember that Kelly doesn’t feel that low serotonin is a factor in anxiety and depression.

  • I will be following up with some of the other speakers like Josh Friedman, Hyla Cass, Amy Day and Corey Schuler.

What do Dr Weil and Nora Gedgaudas think?

I’d like to share some perspectives from a few others:

  • On Dr. Andrew Weil’s site

I checked with David Perlmutter, M.D., a neurologist colleague in Florida, about the accuracy of urine testing for neurotransmitters. He told me that neurotransmitters and their precursors are produced in abundance throughout the body and to assume that what is collected in the urine reflects what’s going on in the brain is a stretch.

Unfortunately Dr. Weil goes on to discredit salivary cortisol testing which has plenty of research supporting how effective it is!

  • Nora Gedgaudas, author of Primal Body Primal Mind states this on her site:

I have considered the urinary testing approach and was even enamored of the concept at first. Once I looked into the idea more closely, though, it just didn’t add up for me. I have been using amino acids now to address issues of mood, health and cognitive functioning for over 20 years. I have never used anything other than mood/symptomatic screening to guide amino acid supplementation. Results tend to be uniformly good to excellent. The sheer overwhelming complexity of amino acid/neurotransmitter activity in the human body/brain-and the compartmentalized nature of the biochemistry of each seems to best lend itself to a more functional and symptom-related evaluation. Lab testing simply falls short of the mark here.

I could not agree more with Nora’s comments. These are my exact thoughts. Here is the amino acids mood questionnaire I use with my clients. Based on symptoms we do amino acid trials and based on their response (which can happen as quickly as 5 minutes) we know if we’re on the right track.

I’ll be the first to say we don’t always have all the research to support what we do in the nutritional/integrative world and do agree that testing is extremely valuable but in this case I do not recommend urinary neurotransmitter testing as it does fall short in terms of accuracy and consistency.

I’d love to hear your thoughts and experiences. Have you been tested and had good results? Bad results? Are you a health practitioner and say ‘yes’ or ‘no’ to this testing?

Filed Under: Anxiety and panic, Questionnaires, Testing Tagged With: amino acid questionnaire, anxiety, depression, urinary neurotransmitter testing

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