I had not investigated DPA as I am a joyful, happy person. But recently I have been so depleted that I benefitted much from taking licorice to boost cortisol (who knew cortisol isn’t always to be lowered?)
Your presentation convinced me to try DPA as when I get depleted enough I get weepy (not sadness, just from being physically drained). Wow. I used a 500 mg dose of Lidke Endorphigen in the afternoon, and that has made a startling difference. I have more resilience now, more buffer, in the caregiving work I do, and just the oops’s of life.
I have been an avid note-taker of your summits and the interviews you give on the summits of others, and have recommended your book and blog to precious ones looking for answers to their health challenges.
Because of your diligence, I have been greatly helped by using GABA, 5-HTP (seems to work better for me than tryptophan), and tyrosine (so my thyroid glandular works more effectively).
Thank you ever so much for presenting information with evidence backing in a way that truly meets my curious, investigative, analytical mind. I love to know the whys and hows of things.
Ellen shared this feedback on one of the blogs after she heard me talk about DPA and low endorphins on The Anxiety Summit 5: Gut-Brain Axis. I’m sharing her wonderful results to give you a practical resource if you find yourself depleted and needing resilience as a caregiver. I’m also sharing this in order to illustrate that it’s not always easy to know when to trial a certain amino acid.
Ellen commented that she appreciated understanding the whys and hows of things. She is referring to my explanation of how DPA (d-phenylalanine) works. It’s an amino acid that destroys the enzyme that breaks down endorphins and thereby helps to raise your endorphins. With low endorphins you can feel very weepy, overly emotional, be extra sensitive to emotional pain, be sensitive to physical pain, and indulge in comfort/reward eating. You also often don’t feel joy.
Even though she was well versed in the use of GABA, 5-HTP and tyrosine (and seeing results), she had not investigated DPA. She described herself as a joyful and happy person so she didn’t think she needed DPA.
But her caregiving work (and other health and life challenges) had left her depleted and she started to feel weepy. And she is happy to share that DPA reversed that feeling. I’m thrilled for her and appreciate her for sharing.
The DPA product, how best to use it and how it differs from DLPA
Ellen mentions Lidtke Endorphigen which contains 500 mg of DPA. This product has been a long-time firm favorite with my clients and those in my community.
I used to recommend simply chewing the capsule to get the quickest and best effects and this worked well when it was produced in a gelatin capsule. Now it’s made with a cellulose capsule and chewing doesn’t work at all well, so opening the capsule (or just biting off the top) and tipping the powder into your mouth works best.
I’m often asked about the difference between DPA and DLPA (dl-phenylalanine) so if you have this question you can read more about that here.
Some of the supporting research
Research supports the use of DPA for helping to ease depression and the fact that caregivers are prone to an emotional burden.
It is proposed that the enkephalinase [a subgroup of endorphins] inhibitors may be effective in a number of human “endorphin deficiency diseases” such as depression…
Caregivers of hemodialysis patients may experience a significant burden and an adverse effect on their quality of life. Emotional aspects of caregivers (particularly female spouses) and patients are important predictors of burden.
The study mentions that “Social support and psychological interventions should be considered to improve caregiver life and patient outcomes.”
There is no research that I am aware of that has found DPA to be beneficial for caregivers but until we have that research, let’s include nutritional support based on clinical results we see.
This case, Caregiving Burden, Stress, and Health Effects Among Family Caregivers of Adult Cancer Patients, illustrates what many caregivers experience: “extremely high levels of psychological distress, including anxiety, depression, worry and extreme loneliness.”
Ellen was already using GABA, 5-HTP and tyrosine when she added DPA, so as a caregiver she was already addressing her low GABA physical-type anxiety (with GABA), low serotonin worry-type anxiety (with 5-HTP) and low dopamine low-energy/low mood (with tyrosine). Adding DPA was the cherry-on-the-top for her weepiness and low resilience, and gave her more of a buffer.
Resources if you are new to using the amino acids as supplements
If you are new to using any of the amino acids as supplements, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see all the symptoms of neurotransmitter imbalances, including low endorphins).
If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.
There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, self-medicating with alcohol and more.
The book doesn’t include product names (per the publisher’s request) so as mentioned above, this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.
As mentioned above, Lidtke Endorphigen is the DPA product I’ve had the most success with (and it can be found in my online store). Doctor’s Best D-phenylalanine is also a good product.
If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA Quickstart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support. There are many moms in the program who are having much success with their kids.
You can then use this knowledge to then trial DPA and other amino acids or move on to the Amazing Aminos for Anxiety Program and get help there.
If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids with success with their clients/patients.
If you’re a caregiver have you used DPA with success and if yes how has it helped? And do you feel more resilient?
Has GABA, 5-HTP (or tryptophan) and tyrosine also helped you?
What else helps you as a caregiver and what advice would you share with others taking care of a loved one?
If you’re a practitioner, do you use DPA with your clients/patients?
If you have questions please share them here too.
How do I order from you
Claire
You can order from my online store. You can find the products I recommend here and instructions on setting up an account https://www.everywomanover29.com/blog/amino-acids-pyroluria-supplements/ The DPA is by Lidtke and called Endorphigen.
Hi Trudy, I read your book The Anti-Anxiety Food Solution twice and I’ve read Ann Louise Gittleman’s book Radical Metabolism, both excellent books! I’ve been taking amino acids for 3 years and they have helped me immensely! Mainly, GABA, Tryptophan for insomnia and occasionally Tyrosine for energy in the afternoon and L Theanine for help with keeping my blood pressure down. In Ann Louise Gittleman’s book Radical Metabolism, on page 69 she gives a caution to amino acid supplementation and says they stimulate the mTOR pathway, which can accelerate aging and she said “virtually all cancers are associated with mTOR stimulation” She goes on to say that you want to downregulate mTOR pathways in the body. I was just wondering what you thought about this statement. I’ve had such success with using amino acids and I just don’t want to give them up, but now I’m concerned they could cause cancer (??) Thank you in advance for responding.
K.B.
I’d need to see the research stating that amino acid supplementation stimulates the mTOR pathway and would want to know which amino acids she is referring to in order to be able to comment. Can you share a link and additional information.
It’s wonderful you’ve had such success. To me that is your answer!
Hi Trudy,
I have suffered depression since puberty and have been on antidepressants at least 25 years! (Currently still on Bupropion). A naturopath helped me get off of Escitalopram about 4 months ago but I have been progressively more emotionally labile since then. I can’t function like this and am considering going back on it. (I want off of them because I believe they are causing my side effects of ZERO libido, tremors and possibly tinnitus. The tremors have lessened since stopping Esc.)
My question is whether it is actually possible for my brain to rebalance after all these years? I’m feeling hopeless.
I appreciate any advice you can offer. Thank you!
Desperately seeking…
RR
Robin
Yes it is possible to rebalance the brain and body but it can be more challenging after antidepressant use in some folks. You don’t mention if you’re using tryptophan or GABA or tyrosine or DPA to help? These amino acids help so much during and post taper.
Some folks choose to go back onto antidepressants when the taper has been too fast and taper much more slowly (like over a year or more). I also find folks do better when they are nutritionally stable before tapering and taper in the summer rather than the winter.
My book “The Antianxiety Food Solution” https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/ is a great resource for a comprehensive approach that includes the amino acids and diet.
Trudy, if I am intolerant of nutrasweet can I take this supplement?
Christine
I have not seen issues when someone is intolerant to nutrasweet
Trudy thank you for this! I think this is what my son needs after being on addrall for so long. I’m guessing after being in fight or flight for so long he has little to no endorphins. We took him off and have tried l-tyrosine and other things but has gained over 100lbs from emotional eating and feeling meh. Not depressed or anxious at all just no desire to do anything motivating unless he is hyerfocused on it. Im going to try this and report back.
Lisa
Please keep us posted on how he does. When I hear emotional eating and feeling meh I think low endorphins but when I hear low motivation and that someone was on ADHD meds I also think low dopamine and tyrosine. It’s common for folks to need to address more than one neurotransmitter imbalance.
be sure to read the amino acids chapter of my book “The Antianxiety Food Solution” https://www.everywomanover29.com/blog/the-antianxiety-food-solution-by-trudy-scott/