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What do I use instead of Seriphos to help lower high cortisol that is affecting my sleep and making me anxious at night?

By Trudy Scott 28 Comments

seriphos alternative

Seriphos, a phosphorylated serine supplement that I rate highly and have personally used with success, is not available right now. I’ve had a number of people reaching out frantically asking for help:

What do I use instead of Seriphos to help lower high cortisol that is affecting my sleep and making me anxious at night?

It’s my top product for addressing high cortisol at night and I’ve been recommending it for years for this purpose (as did one of my mentors, Julia Ross). It’s extremely effective when used a few hours before high cortisol (as measured on a salivary cortisol test).  It also starts to work within about a week for most individuals.

Unfortunately Seriphos has been unavailable for a number of months. The company has no information on when it will be available again but have assured me via email that the formulation will be the same. This is really good news after a previous debacle when the formulation changed in 2016/2017.

Until then, there are some other options that may be an effective alternative. And even if you still have some Seriphos in your calming/sleep stash I encourage you to pay attention as it’s important to have a backup plan for situations like this!

Read on below for information on phosphatidylserine, the cortisol/stress research and how it compares to phosphorylated serine; which phosphatidylserine products to consider instead of Seriphos; other options for lowering high cortisol levels (such as Cortisol Manager, Relora® lactium and bergamot); the amino acid theanine for neurotransmitter support and high cortisol; and additional resources when you are new to amino acids.

What is phosphatidylserine and how does it compare to phosphorylated serine?

From this 2023 paper, Phosphatidylserine: An overview on functionality, processing techniques, patents, and prospects

Phosphatidylserine is the part of cell structure in the body and has many beneficial functions especially in brain-related aging diseases.

Supplementation has been reported to show improved memory and cognition (including ADHD and Alzheimer’ s disease), and also better exercise performance. The research also shows benefits when it comes to lowering cortisol levels and feeling less stressed:

  • One study reported 300 mg/day for 1 month was “associated with feeling less stressed and having better mood in a sub-group of healthy young males.”
  • And another study using a moderate dose of 600 mg/day promoted “a desired hormonal balance for athletes by blunting increases in cortisol levels”, suggesting that phosphatidylserine “partly counteracts the stress-induced activation of the hypothalamopituitary-adrenal axis.”
  • One additional study reported that 800 mg/day for 10 days lowered “plasma cortisol concentrations in healthy inactive males”

As you can see the range of doses varies (which makes sense since we are all unique) but it has been established as a “safe oral supplement capable of attenuating the serum cortisol and creatine kinase responses to acute exercise stress.”

“Lower daily doses (<500 mg/day) for longer duration” are recommended for ongoing cognitive benefits. One study reported improvements in “behavioral and cognitive functions in a group of geriatric patients with cognitive impairment” who used 300 mg/day for 6 months.

Seriphos is unique in that it is a phosphorylated serine product – this is where the magic happens when it comes to lowering cortisol so well. It is similar to phosphatidylserine but as far as I am aware, there is no actual research on phosphorylated serine. They quote studies on phosphatidylserine on their site.

Which phosphatidylserine products to consider instead of Seriphos?

Here are two excellent professional grade phosphatidylserine products to consider. It may be a matter of trial and error to find what works well for your needs, plus adjusting the dose up as necessary.

  • Designs for Health PS 150 – Phosphatidylserine 150 mg: non-soy, sunflower sourced phosphatidyl serine with one capsule providing 150mg, so using a higher dose may be more effective:
    • Feedback from a colleague: “We have equally good results with phosphatidyl serine, but the dose usually needs to be in the 300-500mg range, to equate to what 1 or 2 Seriphos capsules could do.”
    • Feedback from another colleague: “We started using PS150 from DFH and love it.” He often uses this in conjunction with another Designs for Health product called Catecholacalm.
  • Designs for Health Phosphatidylserine Powder 200mg: One quarter teaspoon provides 200mg phosphatidylserine in a powder form.
    • This one is made from soy (GMO-free) but may be easier to use to get higher doses. Per their site the powder is an “excellent delivery system for children and the elderly who may have difficulty swallowing capsules; it has virtually no taste and will dissolve into applesauce or any food.”

Other options for lowering high cortisol levels: Cortisol Manager, Relora® lactium and bergamot

  • Cortisol Manager by Integrative Therapeutics – 2 capsules contain a proprietary blend of: ashwagandha (Sensoril®), L-Theanine, plus a blend of Magnolia (Magnolia officinalis) and 100mg of phosphatidylserine (soy free). I have seen mixed results with this product:
    • A colleague shared this: “Cortisol Manager can be dosed up to 2-3 tablets per day and used with or without additional phosphatidyl serine which can easily go as high as 600 mg.” He has seen salivary cortisol levels shift with this approach and shared: “Interestingly, I never saw those changes with Seriphos despite being a heavy user between 2009 and 2011 so I thought it was just hype.”
    • Feedback from someone on my blog: “Cortisol Manager was too stimulating with the Ashwagandha”
    • Feedback from a practitioner who first used Cortisol Manager personally and then switched to Seriphos at my recommendation: “Cortisol Manager did nothing for me. I dosed it high enough and took it for a month – but I felt nothing. Seriphos, on the other hand, worked the same night, within an hour or two.”
  • Relora®, a proprietary blend of Magnolia officinalis bark extract and Phellodendron amurense bark extract
  • Biotics Research De-stress, contains Lactium®, also known as hydrolyzed casein.
    • I have used this product with clients with good results and based on the research it lowers high cortisol. It’s also calming because it works on the GABAA receptor.
    • You’ll also see Lactium® referred to as alpha-s1 casein hydrolysate, hydrolyzed casein concentrate, and tryptic hydrolysate from bovine milk alphaS1-casein. More on this blog
  • There is very promising research on essential oils lowering cortisol levels – such as bergamot. In this blog I share an animal study that shows very promising results: Acute effects of bergamot oil on anxiety-related behaviour and corticosterone level in rats

both bergamot essential oil and diazepam exhibited anxiolytic-like behaviours and attenuated HPA axis activity by reducing the corticosterone response to stress

The amino acid theanine for neurotransmitter support and high cortisol

Theanine is a calming amino acid that supports low GABA, low serotonin and low dopamine, and has been shown to help with stress levels when salivary cortisol is high.

A 2021 study, A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® l-Theanine on Stress in a Healthy Adult Population, 200 mg of AlphaWave® l-Theanine was shown reduce “salivary cortisol in healthy, moderately stressed adults” and increase frontal region alpha wave activity.This was “indicative of relaxation in the brain and suggest a calming response.”

The authors conclude as follows:

Four weeks of supplementation with 200 mg of l-theanine has been shown to improve trait anxiety scores, suggesting that continued supplementation with AlphaWave® l-Theanine may have positive effects on trait anxiety as well, which may be an important application in longer-term stress management.

As you may already know, I am a proponent of long-term stress management with individual amino acids such as GABA, theanine and tryptophan/5-HTP. And the more I learn about the benefits and mechanisms of theanine the more excited I get!

Additional resources when you are new to using theanine, GABA or other amino acids as supplements

We use the symptoms questionnaire to figure out if low GABA (indicating a possible need for GABA or theanine) or low serotonin (indicating a need for tryptophan or 5-HTP) or low endorphins (indicating a possible need for DPA) or low dopamine (a need for tyrosine) other neurotransmitter imbalances may be an issue for you.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings. I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues. The importance of quality animal protein and healthy fats is also covered.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support. We’ll be launching a budget-friendly homestudy version in a few weeks – sign up for the wait list here (the live version with Q&A is offered only a few times a year). The amino acids GABA and theanine are covered.

If you also need serotonin support, the Serotonin QuickStart Program is a good place to get help. This is also a paid online/virtual group program where you get my guidance on using tryptophan and 5-HTP safely, and community support during 5 LIVE Q&A calls. You can sign up to be notified when the next live launch of this program is happening.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Now I’d love to hear from you …

Have you used Seriphos with success in the past for lowering high cortisol and helping with sleep and middle of the night surges or adrenalin-type anxiety and panic?

Have you had success with any of the Designs For Health or other phosphatidylserine products? How much did you need to use to get results?

What about Cortisol Manager, essential oils, Relora or lactium? Or something else?

Do you also use theanine with success? And if yes, how much helps you?

Feel free to post your questions here too.

BeSerene™ GABA/theanine cream eases severe muscle tension in her neck/shoulders, prevents her bad headaches and quells her anxiety

By Trudy Scott 9 Comments

beserene

Hi there… I wanted to add my ‘two cents’ to the discussion about the BeSerene™ GABA/theanine product that you recommend. I LOVE it! I suffer from low GABA levels, which result in my having severe muscle tension in my neck and shoulders. Often, that resulted in bad muscle tension headaches, for which I couldn’t find anything to bring relief. The BeSerene™ GABA/theanine cream has been a real game changer.

If I wake up with one of those headaches in the middle of the night or in the morning, I use two pumps and rub it on my tight neck and shoulder muscles and within 15 minutes, I can feel the tension melting away! It literally goes away! I have  even been able to prevent a headache from occurring by using it on my neck muscles before I go to bed at night.

Insofar as anxiety, I get relief from that as well, because generally I start to get anxiety once the headaches start, as I never know if it is going to be manageable with just an ibuprofen or two, or if it is going to be one of ‘those’ headaches, i.e. a migraine that lasts for a day or more! Unfortunately, once the anxiety starts, it makes the muscle tension headache worse, which makes the anxiety worse, and it’s just a horrible vicious cycle!

So, since the BeSerene™ cream works so efficiently on the muscle tension, it quells the anxiety that usually follows!

It has changed my life, and I don’t know of any other product I can say that about. I can honestly say that I will not allow myself to ever be without it now!

Thank you so much Trudy, for recommending this product!

Lisa is a woman in the community who reached out to me via email with this message raving about how life-changing this cream has been for her. I am thrilled for her and never get tired of hearing results like this. I’m not surprised either and love to share these kinds of results! She kindly gave me permission to share, saying “I want others to experience what I have with this product!”

Read on below for more about why she gravitated towards using a cream, other benefits you may expect to see (like a reduction in stress-eating and/or drinking too much wine), my insights into when to consider using a GABA/theanine cream like this and how to use it, where to purchase this exact cream and additional resources if you are new to using GABA.

Why did Lisa gravitate to using a GABA/theanine cream?

Lisa shared that she just couldn’t seem to tolerate the sublingual or oral GABA:

I have tried sublingual GABA products but haven’t had much success, as I haven’t been able to find any without alcohol sugars (xylitol, sorbitol, etc.) Those ingredients give me a terrible taste in my mouth and I just can’t tolerate them. (Why can’t they make one with just real sugar from nature?)

Plus, I haven’t had a lot of success with the oral products as they just take too long to work on the headaches/muscle tension.

I’m really glad she recognized her symptoms were due to low GABA – muscle tension and pain, in conjunction with feeling physically anxious are common. And that she didn’t give up on GABA and persevered until she found what works for her symptoms.

What about other forms of GABA?

However, my advice for someone in Lisa’s situation is not to give up on other GABA products if she finds she needs additional support in the future or finds herself without the cream. With regards to taste and time to work, I recommend a GABA-only (or GABA/theanine) capsule opened on to the tongue or a GABA (and/or theanine) powder – both held on the tongue for 1-2 minutes for quick results.

Stress-eating and self-medication with wine are classic signs of low GABA

Interestingly, stress eating is not an issue for her but wine may be:

I’ve never really had any issues with stress-eating. In fact, I usually have no appetite when I’m stressed out! (That’s where the wine comes in…lol!)

We may self-medicate with wine when GABA is low because it relaxes us physically, helps us fit in socially and feels calming and pleasant. It’s mistakenly used to try and improve sleep but typically makes things worse.

Alcohol consumption damages the gut, depletes B vitamins (especially thiamine/vitamin B1) and zinc – and it’s addicting.

GABA can stop that addiction in its tracks so there are no feelings of deprivation. The reasons we are drawn to GABA are addressed too. And amazingly there is research that GABA may actually heal the gut after alcohol consumption.

Bumping up the GABA/theanine cream may help or considering one of the other GABA products mentioned above may be better.

Low GABA symptoms

As a reminder, if you are new to GABA, it’s an amino acid that helps to address low GABA levels and the associated symptoms: physical tension and feeling anxious, feeling worried or fearful, panic attacks, stiff or tense muscles, insomnia, feeling stressed and burned-out, craving carbs/alcohol for relaxation and calming, intrusive thoughts, spinning/poor focus, fear of heights, rectal spasms, burning mouth, and visceral pain/belly pain with IBS. See the most current list of low GABA symptoms here.

When to consider using a GABA/theanine cream like this?

These are some of the applications I consider

  • When other GABA products haven’t worked (like in Lisa’s situation)
  • When looking for something in addition to other GABA products, for example, GABA powder in the day while at work or play, and GABA/theanine cream at night for tension and sleep issues
  • When there is a specific need for a topical application – like with neck and shoulder tension or belly pain or period pain or leg spasms etc
  • For an aging parent with Alzheimer’s disease (and sundowning agitation/anxiety)
  • For a person with ARFID (avoidant-restrictive food intake disorder)
  • For a person with anorexia or other eating disorder
  • When a child or young adult has autism (with anxiety and sensorimotor issues), a child/adult who struggles with taking supplements and other special needs children/adults
  • For someone with multiple sclerosis (for anxiety and muscle spasms/spasticity)
  • When a person has severe digestive issues and prefers a cream
  • When someone just wants to take a break from sublingual/oral/powder GABA
  • For presurgery anxiety since supplements are typically not permitted (even though there is research showing both help)

Where to purchase BeSerene™ IR GABA and theanine cream and how to use it?

This cream can be purchased online with this link (this has my 15% discount built in – you’ll see the discount applied on the checkout page after you add it to the cart).

Purchase BeSerene™ IR

They recommend applying 1-2 pumps to your temples or wrists.

You could also use 1-2 pumps/squirts on your neck and shoulder (like Lisa did), the forearm or inner thigh (before bed for helping improve sleep), and/or belly (especially if belly pain or IBS/SIBO or PMS pain keeps you awake at night). It can also easily be applied if you wake in the night.

Personally, it’s a product I love at bedtime. I apply 2 pumps on my forearm and then rub my belly with any that is left over. It’s calming, improves my sleep and helps with belly pain at night.

I’m sure you can tell by now that this is a product I endorse. I recommend it to clients and to participants in my GABA Quickstart program. In fact, it’s one of the top ten GABA products I recommend and it’s even included in the training materials/handouts of the program!

Additional resources when you are new to using GABA or other amino acids as supplements

We use the symptoms questionnaire to figure out if low GABA (indicating a possible need for GABA or theanine) or low serotonin (indicating a need for tryptophan or 5-HTP) or low endorphins (indicating a possible need for DPA) or other neurotransmitter imbalances may be an issue for you.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings. I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues. The importance of quality animal protein and healthy fats is also covered.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support. We’ll be launching a budget-friendly homestudy version in a few weeks – sign up for the wait list here (the live version with Q&A is offered only a few times a year).

If you also need serotonin support, the Serotonin QuickStart Program is a good place to get help. This is also a paid online/virtual group program where you get my guidance on using tryptophan and 5-HTP safely, and community support during 5 LIVE Q&A calls. You can sign up to be notified when the next live launch of this program is happening.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Now I’d love to hear from you…

I appreciate Lisa’s willingness to share her wonderful results. Now I’d love to hear from you.

Have you used BeSerene™ GABA and theanine cream and how has it helped you?

How does using a GABA/theanine cream compare with other GABA products you have used (feel free to share specific brands and how you used them – sublingual, capsule-opened, liposomal or powder or even another brand of GABA cream)?

As  I shared above, some folks prefer a cream only and many use a combination of cream and sublingual.

Feel free to post your questions here too.

The correlation between terrible anxiety/panic attacks and collagen

By Trudy Scott 14 Comments

collagen and anxiety

Bea shared her collagen experience and insights on one of the collagen blogs:

I discovered the correlation between terrible anxiety and collagen myself several years ago! Couldn’t find any data about it then so just assumed I was a weirdo. But then my 26 yr old daughter started having terrible panic attacks. And bam! She too had started a collagen supplement! So I realized at least 2 ladies have this trouble! Got me to think about how many women seek anti-aging help with collagen and then also end up on prescriptions to help calm terrible anxiety without seeing the connection. Practitioners don’t seem to know about this. But every vitamin shop I visit hears from me on the anxiety/collagen connection. Perhaps grassroots word of mouth will help others eventually.

And yesssss… for me, bone broth is equally horrible!! Even if it is simmered for only 30 mins.

Thank you for explaining, Trudy!! How fascinating to learn it’s the drop in serotonin! I’ve never tried Tryptophan… just a bit nervous. But I think it’s time. I sure need the bone broth for my waning gut health. And I’m weary of ruminating thoughts lately! Thank you immensely for shining a needed light on how these amino acids help! I only wish I could share lunch with you and pass along my grateful hug!

God bless you, Trudy!

I’m so glad Dea found this correlation for herself and her daughter! Collagen use is on the rise and there is little awareness about these effects on serotonin levels in susceptible individuals. Read on for many of the anti-aging benefits of collagen, more information about tryptophan depletion studies, another similar story, other possible causes, and other blog resources on this topic.

Collagen use as we age: for skin, joints and bone health

Her comment about an increase in collagen use for anti-aging is so true. This 2023 paper, Collagen supplementation in skin and orthopedic diseases: A review of the literature, discusses the many age-related benefits of collagen:

hydrolyzed collagen supplementation promotes skin changes, such as decreased wrinkle formation; increased skin elasticity; increased hydration; increased collagen content, density, and synthesis, which are factors closely associated with aging-related skin damage.

Regarding orthopedic changes, collagen supplementation increases bone strength, density, and mass; improves joint stiffness/mobility, and functionality; and reduces pain. These aspects are associated with bone loss due to aging and damage caused by strenuous physical activity.

This paper mentions these aspects about collagen, that it’s low in tryptophan and that it is not a complete protein i.e. it’s a low biological value protein:

  • Notably, collagen is a low-tryptophan protein, an essential amino acid for humans.
  • Collagen is a source of conditionally essential amino acids (glycine and proline), which are important in some physiological situations.
  • Collagen is a low biological value protein, since its amino acid composition is poor in essential amino acids. However, it has a positive intrinsic value because its amino acid composition is equivalent to that of human connective tissue.

This supports what we have learned from acute tryptophan depletion studies causing low serotonin.

Tryptophan-depletion studies to study the relationship between low serotonin and depression

Here is my first blog explaining acute tryptophan depletion studies (published in 2017) – Collagen and gelatin lower serotonin: does this increase your anxiety and depression?.

Tryptophan-depletion studies have been done for years, as a way to study the relationship between low serotonin and depression.  Often a tryptophan-deficient amino acid mixture is used for this purpose.  More recently, collagen and gelatin are being used.

Collagen and gelatin are an excellent source of these amino acids: proline, glycine, glutamine and arginine, but they do not contain the amino acid tryptophan.

This paper, Pharmacokinetics of acute tryptophan depletion using a gelatin-based protein in male and female Wistar rats summarizes what we find in a number of studies that use gelatin for the purpose of lowering serotonin levels, in order to study the relationship between serotonin and behavior:

The essential amino acid tryptophan is the precursor of the neurotransmitter serotonin. By depleting the body of tryptophan, brain tryptophan and serotonin levels are temporarily reduced. In this paper, several experiments are described in which dose and treatment effects of acute tryptophan depletion (ATD) using a gelatin-based protein-carbohydrate mixture were studied in male and female Wistar rats.

I encourage you to read the above blog to learn about who may be more susceptible to these effects.

I also share my personal experience with collagen consumption and can totally relate to Bea’s story and what clients and those in my community have shared.

Toni used collagen for 8 months – anxiety and panic attacks are off the charts

Toni experienced something similar:

I’ve been using Organic collagen for about 8 months now… love the hair and skin results. My tummy felt better at first but not currently. My anxiety and panic attacks are off the charts: panic attacks, heart racing, sweating, brain fog. I want to escape – like fight or flight. Definitely obsessing and fears. Memory difficulty. I have an upcoming GI appointment to check for Candida /SIBO… but I had no idea this could add to my anxiety. I’ll be looking forward to more information, Seriously.

And a few weeks after stopping the collagen she shared this:

I stopped using collagen. Since then, my anxiety and panic have decreased by less than half. Mild in comparison. I’m definitely taking a long break.

Instead of stopping collagen altogether, my advice is to figure out if low serotonin is the cause and address this with tryptophan or 5-HTP so collagen can be used for its many anti-aging and health benefits.

Is their anxiety due to reduced serotonin or histamine, glutamate or oxalate issues

Keep in mind tryptophan will help and allow collagen, gelatin and broth to be consumed without the increase in anxiety and panic attacks (and sleep issues) only if it is due to low serotonin.

Presumably both Dea and her daughter have other low serotonin symptoms – in addition to anxiety and panic attacks – such as sleep issues, worry, fears, afternoon/evening cravings etc (here is the list of symptoms).  As you can see from Toni’s feedback (above), she does have many low serotonin symptoms.

A trial of tryptophan and symptom reduction (initially until the ideal dose is found) will confirm symptoms are related to low serotonin very quickly. This will also help Dea with her nervousness and ruminating thoughts, help her daughter ease the feelings of panic and help Toni too.

It’s also often helpful to also rule out histamine, glutamate and oxalate issues from collagen, gelatin and broth intake – as all of these factors can contribute to an increase in anxiousness too.

Additional blog posts on the topic of collagen

In case you are new to these potential issues, here are additional blog posts on the topic:

If you are new to this topic and are still skeptical about all this, do read the many comments and stories on these blogs. It’s a way more common issue than you’d think!

Additional resources when you are new to using tryptophan and other amino acids as supplements

As always, I use the symptoms questionnaire to figure out if low serotonin or other neurotransmitter imbalances may be an issue.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control (this is covered in an entire chapter too), sugar cravings, anxiety and mood issues.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support. You can sign up to be notified when the next live launch is happening.

If you need serotonin support, the Serotonin QuickStart Program is a good place to get help. This is also a paid online/virtual group program where you get my guidance on using tryptophan and 5-HTP safely, and community support during 5 LIVE Q&A calls. You can sign up to be notified when the next live launch of this program is happening.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Wrapping up and your feedback

I appreciate Dea for sharing her story on the blog and for sharing this information at vitamin stores – we do need more awareness, hence this new blog on the topic to further help create awareness.

It’s very likely that this is one big contributing factor to the rise in anxiety and sleep issues in perimenopause and menopause. And this is probably made worse because so many practitioners are still not aware.

I thanked her for her kind words, and said I’ll take a virtual lunch and a virtual hug from her.

Have you experienced any adverse effects from collagen, gelatin or bone broth?

Have you been able to continue using them by adding tryptophan?

And why do you use collagen/how is it helping?

If you’re a practitioner are you aware of this issue for certain susceptible individuals?

Feel free to share and ask your questions below.

My kids and I used GABA to get through Hurricane Helene – I recommend it for everyone’s 72-hr kit now

By Trudy Scott 2 Comments

gaba in hurricane

My kids and I used GABA to get through Hurricane Helene. Freeways broken in 3 directions, no comms, no gas, no power, etc. GABA noticeably kept us calmer even as the days went by. It helped us stay calm enough to think about our escape plan and jump on opportunities to find gas and water.

So grateful we learned about it [from you years ago] and had it on hand… I recommend it for everyone’s 72-hr [emergency preparedness] kit now.

Alecia shared her wonderful results with GABA on a Facebook post. I’m sorry they went through this but I am so happy GABA helped. I also wish everyone had GABA on hand for situations like this.

She now also uses a manual device for vagus nerve stimulation (VNS) and feels a combination of “GABA and VNS would have been incredible.” I’m a big fan of a B complex too and zinc and extra B6 if you have pyroluria because the added stress depletes these nutrients and makes things worse. And serotonin and endorphin support can often be helpful too. More on all this below and details about the GABA product she used and what dose helped her.

Which GABA product helped her and her family and how much did she use?

I asked Alecia to share how much GABA helped during and after the hurricane and which product worked for her? And if she had been using it before for day-to-day low GABA symptoms of feeling anxious, stressed, overwhelmed with physical tension and sleep issues.

We use the pharmaGABA by Natural Factors. I usually only need 100 – 200 mg in my regular life. During the hurricane I needed 300 mg pharmaGABA a couple of times a day. And more when waiting in a gas line. Such intense stress. GABA really took the edge off.

It’s always helpful to know your baseline dose i.e. what you use on a day-to-day basis. And to expect that dose to increase in times of the added stress in the midst of the hurricane and the immediate aftermath – as it did for Alecia. She needed a higher dose and used it more frequently.

You may often find you need to continue with the higher dose for a few weeks to months after the disaster, especially during the clean-up and rebuilding period.

One other factor to consider is the form of GABA. She used pharmaGABA with much success and many do very well on this form but I find more folks do better with GABA. GABA works best when used sublingually, capsule-opened, powder (all held on the tongue 1-2 mins) or cream, and a low starting dose is used, and increased to find the optimal dose.

Vagus nerve stimulation (VNS) as an added benefit

Alecia now also uses a manual device for vagus nerve stimulation (VNS). She had it during Hurricane Helene but had not yet used it:

A combo of GABA and VNS would have been incredible. I found out my mom was diagnosed with stage 4 cancer the next week and finally started using both GABA and VNS. Game changer combo.

She has the Hoolest veRelief Prime device and says this:

I love the Hoolest VNS. It helps with anxiety, sleep, digestion, and higher performance. I like level 4 but my kids prefer level 1.

I used it daily for about 4-6 months and then I started to heal deeply. Now I only need it once every week or two.

(I did hear that her mom’s treatments are working)

Vagus nerve stimulation, anxiety, GABA and the potential with VNS devices

This paper, Vagus nerve stimulation: a physical therapy with promising potential for central nervous system disorders, discusses how “vagus nerve stimulation influences the central nervous system through the GABA system” and the fact that “VNS has been shown to alleviate anxiety symptoms”, depression, obsessive-compulsive disorder (OCD), panic disorder, and post-traumatic stress disorder (PTSD). Much of the research has been done with implantable vagus nerve stimulation (iVNS) but the potential with non-invasive vagus nerve stimulation devices is really exciting.

What is so interesting is that “Vagus nerve stimulation influences the central nervous system through the GABA system” and it’s “speculated that part of VNS’s therapeutic effects …might involve the GABA system.”

VNS benefits are also seen via impacts on serotonin and dopamine, BDNF (brain-derived neurotrophic factor), by reducing inflammation and the secretion of inflammatory cytokines and promoting neuroprotection.

You can read more about vagus nerve support on this blog: Vagus nerve rehab with GABA, breathing, humming, gargling and key nutrients. I share my vagus nerve/throat issue and how manual vagus nerve support exercises and GABA helped me.

Using a good B complex and the pyroluria protocol too

I told Alecia that I’m a big fan of a good B complex and the pyroluria protocol too. I share more in this blog – Nutrition solutions for psychological stress after a natural disaster.

If this is all that can be managed it would be my first choice for everyone. In fact, if you live in an area prone to hurricanes, floods, fires etc. I’d recommend being on a B complex all the time.

My colleagues Bonnie Kaplin and Julia Rucklidge published this paper in 2015: A randomised trial of nutrient supplements to minimise psychological stress after a natural disaster. Those consuming a B-Complex and a broad-spectrum mineral/vitamin formula showed significantly greater improvement in stress and anxiety than study participants consuming a vitamin D supplement.

It is well known that pyroluria symptoms are made worse in times of heightened stress. If you are on protocol for pyroluria, additional zinc and vitamin B6/P5P is likely going to be needed short-term too.

In addition to GABA I also mention serotonin and endorphin support:

  • Serotonin support with tryptophan or 5-HTP, especially if you’re feeling sad, worried, imagining the worst, feeling fearful and having problems sleeping. More on tryptophan products.
  • Endorphin support with Lidtke DPA if you’re feeling especially emotional and weepy and grieving the loss of your home and community. More on endorphins here.

And I also include some resources for disaster preparedness and things to consider after the fangers have passed (like mold toxicity).

Additional resources when you are new to using GABA and other amino acids as supplements

As always, I use the symptoms questionnaire to figure out if low GABA or low serotonin or other neurotransmitter imbalances may be an issue.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control (this is covered in an entire chapter too), sugar cravings, anxiety and mood issues.

The book doesn’t include product names (per the publisher’s request) so this blog,The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support. You can sign up to be notified when the next live launch is happening.

If you need serotonin support, the Serotonin QuickStart Program is a good place to get help. This is also a paid online/virtual group program where you get my guidance on using tryptophan and 5-HTP safely, and community support during 5 LIVE Q&A calls. You can sign up to be notified when the next live launch of this program is happening.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Wrapping up and your feedback

I appreciate Alecia for sharing her story and giving me permission to share on the blog.

Do you have GABA on hand all the time and include them in your 72-hr emergency preparedness kit?

Have you found vagus nerve stimulation (VNS) to be helpful – either manual exercises (which ones help you) or using a device (which one helps you)?

What about B vitamins and the pyroluria protocol – do they help too?

If you’re a practitioner do you recommend GABA, VNS, B vitamins and the pyroluria protocol?

Feel free to share and ask your questions below.

I feel so dependent on my nightly “cocktail” of GABA, 5-HTP, melatonin and Ambien for insomnia – how do I reduce them?

By Trudy Scott 3 Comments

reducing gaba

I have had insomnia for years. I have used GABA Calm with good results and also 5-HTP, melatonin and Ambien. Recently I discovered I have mild sleep apnea and have made huge progress in modifying my night awakening.

With my sleep apnea issues addressed, I would like to try to reduce my supplements and the Ambien… but the thought of this causes more anxiety. I feel so dependent on my nightly “cocktail”.

What is the best way to reduce the fear of withdrawal and my nagging brain that tells me I “need” these things?

Many thanks for all the wonderful information you share!

Lynn asked this on one of the blogs and since it’s a common question I’m sharing my feedback in this new blog post. I’m pleased to hear she has discovered sleep apnea is a factor as it’s not always checked and it definitely can cause disrupted sleep and waking in the night.

There is no need to taper amino acids and melatonin but I typically have clients gradually reduce them, one at a time, especially when they are concerned and are not sure how much they may still be helping.

She has a nagging feeling she still needs these supplements, feels dependent on them and feels anxious about stopping. All of this, in conjunction with the fact that stopping a sleep medication such as Ambien can also cause rebound insomnia has me advising a go-slow approach in a situation like this. Also, Ambien does need to be tapered very slowly and under medical supervision, so she would need to keep this in mind too.

A go-slow approach and one amino acid at a time

Lynn may still need one or more of the GABA, 5-HTP and/or melatonin and we don’t want to lose any gains.

As mentioned above, there is no need to taper amino acids and melatonin but I typically have clients gradually reduce them, one at a time, especially when they are concerned and are not sure how much they may still be helping.

I would start with assessing other low GABA symptoms and other low serotonin symptoms and if there are none, start with reducing either GABA or 5-HTP over a few weeks, watching for worsening sleep or other symptoms showing up. She could then do the same with melatonin.

As a reminder, other than sleep issues (with physical tension at night), these are low GABA symptoms: feeling anxious with physical-tension and stiff-and-tense-muscles, overwhelm, feelings of panic, and the need to self-medicate to calm down, often with alcohol but sometimes with carbs and sugary foods. You can also experience anger, rage and agitation, poor focus, intrusive thoughts/overactive brain, spasms, visceral pain/belly pain with IBS and more. You can read the entire list of low GABA signs and symptoms here.

With low serotonin, we see sleep issues with ruminating thoughts and worry (at night too), and fears, phobias, ruminations, obsessing, feelings of panic, perfectionism and lack of confidence, low mood, rage, anger and irritability.

Lynn has a nagging feeling she still needs these supplements, feels dependent on them and feels anxious about stopping. All this is a clue she may still need them or at least need one or more to some extent. Doing a reverse-trial of reducing each one, one at a time, with careful tracking is my approach.

I would tackle the above amino acid and melatonin reduction – if she decides to go ahead with it – only AFTER she has worked with her prescribing doctor on a slow taper on the Ambien. Stopping a sleep medication such as Ambien can cause rebound insomnia/discontinuation syndrome and she may find she does still need nutritional support to tide her over the Ambien taper period. This may be the same as she is currently using or she may even need to adjust upwards on one or more.

Ambien: dependence, withdrawal, rebound insomnia, slow tapering, falls and memory issues

Ambien/Zolpidem “is a non-benzodiazepine receptor modulator primarily used in the …short-term treatment of insomnia aimed at patients with difficulty falling asleep,” increasing “GABA inhibitory effects leading to sedation.”

I seldom see it used short-term i.e. 7 to 10 days. With longer-term use, “this drug has a high potential for overuse and daily dependence” and “withdrawal symptoms may occur if the zolpidem dose is tapered off rapidly or discontinued.”

Other factors to be aware of:

  • Complex sleep behaviors can occur after using zolpidem, such as sleep-driving, sleep-walking, and engaging in activities while not fully awake
  • Changes in behavior and abnormal thinking have been reported after zolpidem administration. In addition, patients have demonstrated aggressiveness and extroversion uncommon for the person’s usual behavior
  • Worsening of depression or suicidal ideation may occur with zolpidem therapy

I encourage you to read the article here and be fully informed.

This 2024 paper supports that “long-term use of Zolpidem may lead to drug tolerance, dependence, rebound phenomena, and withdrawal symptoms, making discontinuation difficult.” Other concerns include: dizziness, headache, falls, and cognitive decline.

Many of the papers published prior to 2023 do not report many of these issues, however awareness is growing. This 2024 paper, Case report: Additional grounds for tighter regulation? A case series of five women with zolpidem dependence from a Brazilian women-specific substance use disorder outpatient service, also reports adverse effects in women such as “memory and social impairment, falls, seizures” and “withdrawal symptoms, including rebound insomnia, social impairment, and craving.”

The authors recommend tighter regulation, stating that: “The surge in zolpidem prescriptions, driven by its perceived safety and low abuse potential compared to benzodiazepines, may lead to a global health issue of dependence.”

Because of much of this it’s important to work with the prescribing doctor on doing a very slow taper under their medical supervision. She may need to adjust her amino acids up during the taper period if her sleep gets worse in the short-term. And then do the taper approach I mentioned at the start of this blog.

With these safety, dependence and withdrawal issues, I would love to see GABA, tryptophan/5-HTP and/or melatonin (and other nutritional and functional medicine approaches), addressing sleep apnea and lifestyle factors/sleep hygiene be considered as the first approach for sleep issues – instead of Ambien/Zolipdem.

Additional resources when you are new to using GABA, 5-HTP and other amino acids as supplements

As always, I use the symptoms questionnaire to figure out if low serotonin or low GABA or other neurotransmitter imbalances may be an issue.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control (this is covered in an entire chapter too), sugar cravings, anxiety and mood issues.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Wrapping up and your feedback

I appreciate Lynn for asking this question and want to acknowledge that she is wise to be cautious and have concerns about the best way to tackle this. And she may find she does have a physical dependence on the Ambien.

Have you found that GABA, 5-HTP and/or melatonin helped/helps with your sleep issues?

And is sleep apnea a factor for you too?

And have you been prescribed Ambien and had any of the issues mentioned?

And how have you adjusted your amino acids and other sleep supplements as you’ve tapered your sleep medication?

Feel free to share your feedback and ask your questions below in the comments section.

I ran out of GABA and was so irritable and quick to rage (impacting my relationship with my son.) Back on it and feel so much calmer.

By Trudy Scott 5 Comments

gaba for rage

Kaurie shared this feedback in the Facebook community:

I haven’t been taking my GABA for awhile (I ran out and forgot to order) and was soooo irritable and quick to rage. Back on it and feel sooo much calmer. Hopefully that’s the trick or I’m not sure what to do as it’s impacting my relationship with my son.

It’s not a good thing when it starts to impact your relationships. I was curious what this looked like for her and when I asked she shared this:

Any little thing will trigger me i.e. I couldn’t log onto my booktopia account- I ended up throwing my phone so hard it smashed (I had to buy a new phone which I couldn’t afford at the time). I get irritable at the tiniest things.

The good news is that a few days later she shared this: “GABA definitely seems to be helping!” 

I’m thrilled for her and these great results, and appreciate her sharing and allowing me to share! I hope this continues to improve her relationship with her son and in other areas of her life too.

And in case you’re wondering, once you know your ideal dose of GABA it does work that quickly, provided it’s used sublingually, capsule opened, in powder or liposomal form or as a cream.

What we typically see with low GABA levels and some less-recognized signs

Low GABA is typically associated with feeling anxious with physical-tension and stiff-and-tense-muscles. The other common symptoms we see with low GABA are overwhelm, feelings of panic, and the need to self-medicate to calm down, often with alcohol but sometimes with carbs and sugary foods.

Sleep problems can also be caused by low GABA and you’ll experience physical tension with this (rather than the ruminating thoughts and worry which is the low serotonin type of insomnia). It’s not uncommon to experience both low GABA and low serotonin.

You can also experience anger, rage and agitation when GABA levels are low – this is not as recognized as the more common anxiety-related low GABA signs. You can read the entire list of low GABA signs and symptoms here.

This list includes other less-recognized signs of low GABA such as: inability to prioritize planned actions, poor focus/ADHD and spinning, intrusive thoughts/overactive brain, fear of heights, rectal spasms, visceral pain/belly pain with IBS, bladder pain/interstitial cystitis and urgency, Lyme-induced anxiety, globus pharyngeus (lump in the throat) and laryngospasms/“choking” episodes/swallowing problems, poor sensorimotor skills and sound and tactile hypersensitivity

Some possible GABA/glutamate mechanisms that may trigger rage and irritability

A letter, Tiagabine for Rage, Aggression, and Anxiety, published in the Journal of Neuropsychiatry and Clinical Neurosciences in 2015, offers some indirect support for this GABA rage observation. They are discussing patients with treatment-resistant rage and aggression and they propose that:

Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter, may be critical in the neurochemical control of aggressive behavior.

They share that the prescription medication called Tiagabine, a selective GABA reuptake inhibitor (SGRI), increases synaptic GABA availability. They report that 20 out of 36 patients aged 15-54 years (69%):

with symptoms of rage, aggression, or anxiety in association with one or more of the following disorders: bipolar, intermittent explosive, major depression, panic disorder, attention deficit hyperactivity disorder, or substance abuse …demonstrated a good or excellent response to tiagabine, with reduction or elimination of the symptoms of rage, aggression, or anxiety.

This paper, looks at females with bipolar disorder and ADHD and discusses the role of glutamate and GABA in impulsivity and aggression: “On a neurochemical level, glutamate and γ-aminobutyric acid (GABA) are considered important regulatory metabolites.”

GABA likely also helps quickly because of reduced anxiety, improved sleep, and being easily able to quit or eat less sugar, and quit alcohol too.

Based on some research I’ve found and my experience with GABA, I suspect GABA may also help in these ways over a longer period: countering a histamine reaction, reducing inflammation and impacting cytokines, improving progesterone levels, beneficial impacts on the microbiome, supporting the liver and toxin removal (such as fluorides), gut healing and reducing high blood pressure.

Low serotonin and low dopamine, as well as low GABA

Rage and anger has always been associated with low serotonin but we now know other neurotransmitters are involved too. The authors of Aggressive behavior and three neurotransmitters: dopamine, GABA, and serotonin–a review of the last 10 years state this:

The regulation of aggression by a wide spectrum of neurotransmitters is well known.

Serotonin has shown both inhibitory and stimulating effects on aggressive behavior, depending on the brain region measured and specific receptors where it acts.

Dopamine and the mesocorticolimbic system associated with reward seeking behavior are also associated with aggression. Dopamine can sometimes enhance aggression and sometimes reduce the impulsivity that might lead to abnormal aggression.

γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter, and its relationship with aggressive behavior is extremely complex and highly associated with serotonin.

We use tryptophan and/or 5-HTP when there is rage, anger, irritability and other low serotonin symptoms of worry, fears, ruminations, obsessing, feelings of panic, perfectionism and lack of confidence. I have seen these amino acids change lives.

We use tyrosine for low dopamine symptoms of low mood, low motivation, poor focus and low energy. I have yet to see tyrosine help with anger, anger and irritability but it makes sense that it would reduce the impulsivity that may lead to an anger outburst or “abnormal aggression.”  Interestingly I have seen tyrosine actually be calming for a few individuals. It’s highly unusual but it does happen from time to time, as this gentleman experienced.

GABA for rage, dark moods, OCD and histamine flares

Here are some additional blog posts on similar topics:

My son who is 19 and on the autism spectrum was having issues with outbursts of anger and stuttering.  These issues seemed to worsen during his senior year of high school. Since starting GABA and tailoring his dosage from Trudy’s instruction and feedback, we have seen a 90% reduction in stuttering and 80% reduction in anger and outbursts.  We have done many supplemental protocols over the years and this is one of the few we have seen have an impact.

GABA worked amazingly for us during a flare! Flares began with OCD [obsessive compulsive disorder]and anxiety increasing before our eyes and then the rage followed.

Additional resources when you are new to using GABA and other amino acids as supplements

As always, I use the symptoms questionnaire to figure out if low serotonin or low GABA or other neurotransmitter imbalances may be an issue.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control (this is covered in an entire chapter too), sugar cravings, anxiety and mood issues.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Wrapping up and your feedback

Have you found that GABA helps your rage and irritability issues? How do they show up for you and does this also impact your relationships?

Or do you find serotonin support with tryptophan or 5-HTP help more?

Or have you found tyrosine (to support low dopamine) works best for you?
Or is it a combination of the above?

Feel free to share your feedback and ask your questions below in the comments section.