I have not had any clients experience the need to taper or slowly wean their tryptophan dose or report tapering side-effects similar to those they experienced when tapering off an antidepressant. However, I recently had someone ask this question on the blog (and then had someone else ask a similar question) so I’m sharing these questions and my responses in the hope of gleaning some additional information (and educating you if this applies to you). I never say never and am always learning. I’m also very interested to know how common this is and what some of the underlying factors could be.
Here is the question that was asked by Lara (we’ll call her Lara) and slightly paraphrased for clarity:
I’ve been taking 1500 mg of tryptophan for 3 months, and it has helped a lot with sleep and depression. I dropped to 1000 mg about a week ago then 500mg just to see how I’d do without it. I didn’t think it was numbing my feelings, but I am experiencing a return of feeling good.
I’ve been on antidepressants before and I am feeling the same withdrawal effects as when I weaned off meds. This is exactly why I chose to not go back to pharmaceuticals. It was difficult to wean off. How do I taper tryptophan without experiencing withdrawal symptoms? Thank you for your valuable knowledge.
These are the kinds of questions I’d ask a client in this situation:
- Was the 1500mg helping and which low serotonin symptoms were eased?
- How did this change when you reduced to 1000mg and then reduced to 500mg? i.e. did the low serotonin symptoms come back?
- Which antidepressant are you comparing these affects to? And how long ago did you wean off the antidepressant?
- Which brand of tryptophan you are using? (I find Lidtke is the best quality)
Keep in mind that we always want to be sure it’s not a one-off situation. In order to be sure someone is observing mild adverse effects from a supplement I’ll often have my client stop it and then add it back to make sure. And sometimes more than once.
In this instance repeating the process may be a good idea i.e. going back to 1000mg and then 1500mg and then reducing again, carefully documenting in a food mood supplement log.
It turns out that Lara was using the Lidtke tryptophan and she was seeing wonderful benefits for her low serotonin symptoms with none of the typical SSRI side-effects:
the 1500mg before bed with a small carb helped me get to sleep and stay asleep. It also helped with anxiety and depression during day. I tend to be a worrier, have social anxiety, and get stuck with negative thoughts about myself and others. And have very little interest in life.
I was on Zoloft from 2005 – 2009. Got off of that and did Lexapro for only 6 months in 2012. The Zoloft was life changing for me but I did not like the side effects and being on an antidepressant for the rest of my life.
The tryptophan is superior to these SSRIs [selective serotonin reuptake inhibitors] – no sexual side effects, no weight gain, or anhedonia [inability to feel pleasure in normally pleasurable activities].
She describes how she reduced the tryptophan and how her withdrawal symptoms were similar to those she experienced when tapering off her SSRIs in the past:
The withdrawal effects were felt when dropping from 1500mg to 1000mg, to 500mg, then zero over 2 days and they lasted about 3 days. By the 4th day I was no longer feeling bad.
The symptoms are hard to explain – it felt like a tight band around my head, also brain zaps (this is a common SSRI withdrawal symptom many describe feeling in their head).
The worst of it was a deep agitated free-floating anxiety like you’re walking along the edge of a cliff and there’s a physical pain in your gut. Fortunately, it was only present from waking up till around 2pm.
These are questions I’d ask or wonder about
As I mentioned in the introduction, I have not had any clients experience the need to taper or slowly wean their tryptophan dose or report tapering side-effects similar to those they experienced when tapering off an antidepressant. But if this is an issue some individuals experience I’d like to know about it
I’d also like to know how long the tapering side-effects of tryptophan last and how severe the symptoms are. In Lara’s case the symptoms were pretty severe but fortunately they only lasted 3 days which is very much shorter than SSRI tapers.
There could be confounding factors and here are additional questions I’d ask or wonder about if a client experienced similar adverse tapering effects. These are questions you could ask yourself if you have experienced this when stopping tryptophan abruptly:
- Could the prior use of SSRI prescriptions be a factor? (but I have worked with many clients with prior use of SSRIs and not have tryptophan tapering issues)
- What else has changed in terms of stress, diet, hidden gluten exposure, or even the something like a recent introduction of collagen (which may deplete serotonin levels in susceptible folks)?
- Are there hormonal changes that could affect serotonin levels – like in a woman with PMS or perimenopausal or menopausal symptoms? (again, I’ve worked with many women of all ages and haven’t observed this to be an issue)
- If you are prone to the winter blues and reduced winter serotonin, could stopping the tryptophan in the winter play a role? (I have had clients have SSRI tapering issues in winter because of being prone to the winter blues and choose to work with their doctors on their SSRI taper in the spring and summer for this reason)
- Could this also be an issue with summer blues in hot states like Arizona?
- Could any of these play a role: a recent medical procedure, a course of antibiotics (especially fluoroquinolones) or antifungals, poor gut health, a new infection, decreased immunity or increased inflammation?
- Could low levels of these nutrients play a role: vitamin B6, ferritin, magnesium and zinc?
- Would using high doses of vitamin C during the “taper” help reduce some of the symptoms? (this works well as an antidote when you take tryptophan and don’t need it and want to negate some of the negative effects, so may help in this situation)
Stopped tryptophan and felt very angry and down
The other question I had about tryptophan weaning is this one from someone who shared that she had suggested tryptophan for a friend. This friend was
experiencing a lot of ruminating and anxiety. She responded beautifully and felt great. About a year later, she tried to stop taking it, and said she felt very angry and down. Is there a weaning process for the tryptophan?
This could possibly be related to the above and you could pose similar questions but based on on what I see with clients I feel this is more of a matter of stopping the tryptophan too soon while she still had low serotonin – especially if the ruminating and anxiety came back. Feeling angry and down are classic signs of low serotonin.
The questions asked were specifically about tryptophan but they could also possibly apply to some individuals who stop 5-HTP abruptly.
I’d love to hear if you’ve experienced anything like this with either tryptophan or 5-HTP and if yes please share your answers to some of the above questions.
Right now, I’m afraid I don’t have an answer for you on how to taper tryptophan without these withdrawal symptoms: a tight band around the head, brain zaps and agitated free-floating anxiety. Right now, I’m not sure how big an issue this is. If it is common, I’m hoping some of the feedback I receive may provide some answers.
I have been off Zoloft for 16 months now, after 15 years of SSRIs. Have had a really rough withdrawal with major food sensitivity, headaches, dizziness and more. That just seemed to be getting a little better. But have had a week of waking at 3:30 am so tried one 500 mg L Tryptophan last night. Slept much better but felt awfully moody today. Will throw away the L Tryptophan. Had a definite bad reaction.
Kathy
Sorry to hear about your rough Zoloft taper. Tryptophan and other serotonin support, plus overall nutritional support like addressing the gut, adrenals, low zinc, low B6, no gluten, blood sugar control etc etc before starting a taper can help a great deal. Once someone has already tapered from an SSRI, using tryptophan (plus the above nutritional support) can help too.
With all the amino acids I start with the trial method (https://www.everywomanover29.com/blog/how-to-do-an-amino-acid-trial-for-anxiety/) during the day to figure out an ideal amount. For some people 500mg is too high and I would not base my opinion of tryptophan on using it just one time. Less may help the sleep and not cause moodiness in the day. We also need to consider other factors that can cause 3:30am waking – gluten, low blood sugar, high cortisol, SIBO, EMFS etc
Hi Trudy,
I am having bad symptoms like the above from stopping Seriphos. I was in tolerance withdrawal from benzos about 4 years ago and finally finished my tapering last November and have felt amazing but still have sleep issues which I hoped the Seriphos would help with but now it has thrown my back into major withdrawal. Any advice would be greatly appreciated.
Crystal
I am sorry to hear. This is new to me with Seriphos specifically but I am aware this is quite common in a subset of folks who have tapered or are tapering. I’d also investigate other possible triggers like a recent infection and/or recent fluoroquinolone antibiotics
Hi Trudy,
No, I will never take fluoroquinolone antibiotics because of the affect it has on GABA receptors nor did I have a recent infection. My neurotransmitters are damaged because of the Xanax that my doctor put me on for so many years to help me sleep. Whenever someone has been on any type of drug/supplement that has affected the receptors, they have to be very careful taking ANYTHING that affects the receptors. Has I know Seriphos would affect my receptors, I never would have taken it. And I DEFINITELY would never have just stopped taking it cold turkey. But too late now as I am still having withdrawal symptoms 3 1/2 months later. Now I am trying to come off of the Tryptophan and am having awful withdrawal symptoms and can barely function. People need to be aware that aminos are not for everyone, especially those that have had their neurotransmitters affected by medications. And aminos really need to be balanced so as to not cause any further issues. Now I have to figure out how to get off of the Tryptophan and GABA that I have been taking without disrupting my life any further.
I experience the symptom of “a tight band around my head” but have never had a practioner understand it when I’ve described it. This is the first time I’ve had acknowledgement of it. What is that caused by? I have been reading your info and believe that both tryptophan and gaba would help me, and I’m curious about tyrosine too.
Beth
This tight band around the head feeling relates to the tryptophan “taper” Lara describes. Since I don’t ever see this issue with clients I’m don’t know why it happens. I have often heard of these types of symptoms – tight band around the head, brain zaps, increased anxiety – from clients who are tapering SSRIs and benzos.
Other than this you’ll see tension headaches often described with this tight band around the head feeling in some people. More here https://www.mayoclinic.org/diseases-conditions/tension-headache/symptoms-causes/syc-20353977 It may be related to muscle tension and/or stress which tells me that supporting low serotonin and/or low GABA and/or low magnesium may help. Physical approaches may help too – physical therapy, massage, chiropractor, craniosacral work etc
A little off topic but It’s interesting that I had all these symptoms and a few more when I quit my 30+ years of heavy caffeine use. Even though I’ve been off caffeine for a few years there have been a couple of times since I quit when I have accidentally had something with caffeine in it and I will have symptoms for a few days afterwards. Our bodies can do some weird stuff!
MSH
Thanks for sharing! Yes, headaches are very common when in caffeine withdrawal. This is the first time I’ve heard someone relate to the tight band type headache and brain zaps feeling plus anxiety. But as you say our bodies do weird stuff and we’re all unique in how we respond to caffeine, meds, supps, toxins and even foods!
Hi Trudy,
Im taking Effexor 75mg and Celexa 10mg .
Can I use Tryptophan to taper down Celexa? If so, how can I do it?
I’m going to talk to my doctor about it and want to be prepeared.
My concern is the possibility of getting Serotonin syndrome even tho I’m taking low dosages.
I don’t want to take them my whole life 🙁
I really appreciate all you do.
Sonia
I’d discuss the following with your doctor https://www.everywomanover29.com/blog/taper-from-antidepressant-tryptophan-amino-acids/ There is no research on tryptophan used with Effexor or Celexa causing serotonin syndrome but it’s still a precaution and needs medical monitoring. Also, I only have clients use tryptophan when they are on only ONE antidepressant (always with the prescribing doctor’s approval).
Will you be writing a blog on tryptophan cautions? Preliminary research via the Open Medicine Foundation at Stanford is issuing a strong warning about tryptophan supplementation: https://www.healthrising.org/blog/2018/10/18/the-metabolic-trap-shines-during-the-symposium-on-the-molecular-basis-of-me-cfs-at-stanford/
Robin
Thank you for sharing this. It’s very interesting and I will take a deeper look into this and connect with some colleagues for their insights too.
After an initial very quick review of the article here are a few thoughts
– “IDO1 is the first enzyme out of the gate. It breaks down tryptophan correctly most of the time, but two circumstances can make it fail: if it lacks the substrate it needs to do its job, or if tryptophan levels are very high.” One of the key substrates for breaking down tryptophan is vitamin B6 and it’s commonly low, is depleted by many medications (like the birth control pill), stress, gluten issues/leaky gut etc. I’d love to know if this was looked at in the 6 patients, together with other markers of inflammation as we know good levels of B6 help with reducing inflammation. Many with CFS have low levels of B vitamins, especially vitamin B6/pyridoxine https://www.ncbi.nlm.nih.gov/pubmed/10450194
– ME/CFS symptoms are listed: “including impaired cognitive function, movement, and smell, dysautonomia, motor neuron problems, air hunger, dopamine production, POTS, and pain” and are attributed dysfunction of “six nuclei or neurons in the midbrain which control serotonergic pathways in the brain.” I’d like to add that these same symptoms can also be caused by mold toxicity, gluten issues, mercury/lead toxicity, Lyme disease etc. I’d love to see these factors were ruled out in the sample of 6 patients.
– I’d also like to know what tests they used to measure tryptophan and kynurenine
– I don’t have evidence to confirm this statement: “You can actually induce autoimmunity – an autoimmunity you cannot recover from – by taking tryptophan”
Right now they are saying this is an hypothesis and more testing needs to be done
We do know that many many people benefit immensely by taking tryptophan. If this hypothesis does turn out to have some merit it’s not to be taken lightly and we’d need a way to determine who may be adversely affected.
This article doesn’t link to any of the research papers and hope to get more answers once I find them. So for now my comments relate to linked blog post.
I’m curious how you came to learn of this and your interest in this area?
Hi Trudy—
Thanks for the in-depth response. I value the work you do and I value the work that’s going on at the Open Medicine Foundation. I am a psychologist who works with many chronically ill people.
You may wish to go to the Open Medicine Foundation site for links to all the important research taking place at this time:https://www.omf.ngo. Ron Davis, PhD and international colleagues are seeking to eliminate ME/CFS/Fibromyalgia. Currently they are studying the sickest of the sick. It is likely there are different subsets of ME/CFS/Fibromyalgia patients. If you are familiar with Robert Naviaux’s, MD, PhD work on the cell danger response, it is in part sponsored by the OMF.
The OMF has many you tube presentations of the latest research. Their science is excellent and the forefront of clinical interdisciplinary research. I think all functional/integrative clinicians need to be aware of this work.
Robin
My pleasure! I really value contributions and questions from folks in my community – it keeps me current and on my toes
I will check out their material and reach out to them too. And yes I am familiar with Dr. Naviaux’s cell danger study with autism. I blogged about it here https://www.everywomanover29.com/blog/low-dose-suramin-autism-disables-cell-danger-response-speech-calm-focus-play/ But I wasn’t aware OMF was helping to sponsor his work.
Given that you work with many chronically ill people I’d curious to hear if you’ve seen some validity for this serotonin/tryptophan with a subset of your CFS clients/patients? What about other chronically ill patients and which conditions? If yes, are both tryptophan and 5-HTP issues? And were other factors like inflammation and low B6 status considered?
I also can’t help but wonder if using approaches like tryptophan depletion approaches may help those with high serotonin. I blog about collagen/gelatin and tryptophan depletion here https://www.everywomanover29.com/blog/collagen-gelatin-lower-serotonin-increase-anxiety-depression/ One 2014 study didn’t find that ATD/acute tryptophan depletion helped those with CFS (https://www.ncbi.nlm.nih.gov/pubmed/25227994) but it was only 5 patiients.
tapering an amino acid? lol what? that is 100% placebo
Kohl
The amino acids like tryptophan and GABA are very effective for alleviating anxiety, insomnia, PMS, irritability, sugar cravings, negative self-talk, ruminating thinking and much more. Feel free to search my blog for more case studies and research. My book “The Antianxiety Food Solution” has an entire chapter on the topic too. More here https://www.everywomanover29.com/store/aafsbook.html
I have been on Effexor 150mg for 10 years. I was taking tryptophan 1000mg nightly for years. I recently stopped cold turkey. Since, I have found my sleep quality sucks, my anxiety is high, and my mood swings intensified. I have also been having chest pains for two weeks, which the doctor thinks may be spontaneous panic attacks. I’m not sure if the chest pains are related, but I’m going to try taking it again to see if they go away. I hate this.
Ashley
It’s never advised to stop medications cold turkey. I have my clients work with the prescribing doctor on a very slow taper protocol but only after they are nutritional stable (real whole food, quality protein, no gluten, no caffeine, no sugar, good gut health, nutritional deficiencies addressed etc)
Wanted to report that one Lidtke L-TRYPTOPHAN a day caused rapid heart beat in my 17 yo daughter. She went down to 1/2 and it stopped. I know you like to hear our experiences. Any feedback/ advice is appreciated.
Karen
Too much of any of the amino acids can cause an adverse reaction. Rapid heart beat with tryptophan is not common with my clients but anything is possible. Some folks do better on 5-HTP so if someone is benefiting from higher tryptophan but has adverse effects we switch or may use less tryptophan and 5-HTP. I had one young boy use a combination of tryptophan and full spectrum light for the best results.
Hi Trudy, I am looking for help after having an adverse reaction to Zoloft (6 days, 25 mg, cold turkey). I have been off it for almost three weeks but I am in pain in various ways and my insomnia is out of control. I was wondering if there was a health protocol you could recommend to me and/or someone you can get me in contact with that can help me recover. I live in Maryland. Thanks
Lora
I have found that melatonin, GABA and tryptophan or 5-HTP can often help. But I do have my clients get nutritionally stable before starting to taper and this prevents many of the adverse effects. Going cold turkey is never adviseable. But if it has been done we also focus on diet – no gluten, no sugar, no caffeine, gut health, adrenal and hormonal health etc
I wanted to add that right now I am hyperactive to medicine. That’s why I am. Hoping you can possibly direct me towards someone who could help since you are so busy
I once tried to get off tryptophan and for 3 months I struggled to get to sleep, had a lower mood and had persistent night sweats, so bad that I got quite ill from being so cold at night. I started trying to come off 2000mg of tryptophan again a week ago. So far I have got to 1000mg but feel a lot more down and anxious and have horrendous night sweats. I’m not sure where you are based but I am in the UK and it is hard to get prescription grade regularly so Id like to come off it. I also take 200mg duloxetine, 200mg lamotrigine and 1.25mg olanzapine. I’ve taken these for over a year, but before that had over 2 years of med experiments and then ECT.
I am planning to move to Africa as my depression is much more manageable now, but it isn’t possible to get tryptophan there.
So in my experience, getting off tryptophan has been hard in that the night sweats just didn’t stop, for 3 months, until I eventually gave up and took it again. Definite dip in mood, negative thinking, teariness
Lucy
I have no had anyone have to taper tryptophan but then I have not worked with anyone and had them use tryptophan with 3 psychiatric medications so it’s hard to know if these may be a factor or possibly the med experiments and ECT?
If it’s a true withdrawal issue like with SSRIs or benzos a very very slow taper of tryptophan may be needed (these tapers can last up to a year). If I was working with someone with th4ese issues we’d work on root causes of low serotonin and address those. I list some of those root causes here https://www.everywomanover29.com/blog/imposter-syndrome-and-low-serotonin-is-tryptophan-the-solution/
I am curious to hear what product you are using? Can you please share a link and/or let me know what is on the label (front and back)?
Hello.
My story is this: used 18 years quetapune 300mg, tapered it out in 2 years. Started tryptofan right after and now that I tried to get rid of that (all out at once after 2 months use) I got more horrified feeling that I ever got during med tapering. Total surprise that tryptofan was so powerful. Now I have to slowly taper that out too. Would it have been more sensible to not to start with tryptofan in the first place?
Man, 47,Finland
Teemu
I have not had any clients report this type of reaction and would suspect rebound symptoms after the antipsychotic medication (Quetiapine/Seroquel) discontinuation – more on this here https://www.karger.com/Article/Fulltext/506868.
If you’d like to share additional information I may be able to comment further. What was Quetiapine/Seroquel prescribed for and did it help? Also what symptoms did you have while tapering Quetiapine/Seroquel? Once you had tapered the Quetiapine/Seroquel what symptoms were you looking to resolve and did the tryptophan help and how much? Which product/brand did you use and how much? What happened when you stopped using the tryptophan after 2 months of use?
Hi Trudy. I recently had an acute sinusitis and acute insomnia caused by it. This has only last about 4 weeks now but during this time I was put on a sedative Antivan and I am on taper for it about 0.5mg and should be completely off it this week. I was on it for sleep for about 3 weeks. So while the taper started and i have come down to lower dosage, I was asked to supplement with Tryptophan of about 500mg x 2 which i have been taking for about a week. Then I read horror stories about its ban in the 80s and got anxious. So I didnt take it last night. When I fully taper off Antivan this week, do you have any suggestions for alternate sleep aids? Is Tryptophan safe? Does it cause Muscle weakness and cramps? Coincidentally, I am experiencing some muscle cramps, but that could also be due being low on Vitamin D which I have supplemented as well. Please advise. Thanks! 🙂
Shweta
I have used tryptophan with much success for many years. The ban was due to a contaminated genetically modified batch. Another option is 5-HTP.
5htp gave me withdrawals just like lexapro. Brain zaps, dizziness, anxiety. It was less severe than ssri, but definitely bad enough to make note of. Peoples central nervous systems are widely varied. There are people who can fast taper ssri’s with no issues. I’d image they are the ones taking and stopping long term 5htp use.
Terry
Thanks for sharing. May I ask which 5-HTP product, how much you were using and how long had you been using 5-HTP? How long did the withdrawal effects last? Also how long after taking and then stopping Lexapro did this happen and were you on any other medications?
If you take tryptophan, you boost the serotonin in your brain. If you take tryptophan regularly, your brain gets used to this level of serotonin. For some, the brain may lower natural production of serotonin since there is more coming from the supplement.
If you stop tryptophan, it is the same as stopping a serotonin drug – SSRI, SNRI. You may get the same “withdrawal” symptoms as with ceasing an SSRI. This is what people are saying in these comments: brain zaps, increased anxiety, sleep disturbance, etc.
How is it that ceasing an SSRI creates these withdrawal symptoms, but ceasing tryptophan does not?
4 days ago, I quit 200mg of 5-htp after 3 months of use. no brain zaps or dizziness, just extremely high anxiety and my mood is somewhat worsening. I quit taking it cold turkey due to sudden development in side effects (rapid heart rate).
I’ll ride it out, and take some GABA to help with the anxiety. this is certainly a strange occurance, as people don’t seem to have this problem. It’s only day 4, so I’m hoping this doesn’t get worse.
Ethan
I would expect an increase in anxiety and a mood lowering effect if someone still needs serotonin support and stops 5-HTP (or even tryptophan). If the 5-HTP is in fact the trigger for rapid heart rate (I’d want to be sure it is that and not something else) then a switch to tryptophan would be my approach
GABA may help to some extent but GABA supports low GABA type of physical anxiety and not the low serotonin type of worry/ruminating anxiety.
Very well said! Couldn’t agree more!
Hi, I’ve recently quit L tryptophan (I just ran out of it) after a year of daily use. I think I’ve quit about a week ago, not thinking much of it. The past 3 days I’ve felt a weird anxiety, almost panicky, and been feeling very low, depressed. It’s a weird feeling so I was thinking maybe it’s a sort of withdrawal. My history is I’ve had a terrible (traumatic I’d say) withdrawal with an SSRI, which is the reason if the L tryptophan use. I suspect I’ve became extremely sensitive to everything, such as the birth control mini pill. Other factors: it is winter, no sun, I haven’t exercised much and have been not super healthy with my diet. I still feel like my symptoms are a bit odd. I bought the l tryptophan again, we’ll see if I get better anytime soon! x
Nadia
In cases like this I suspect winter blues, lack of exercise, diet and the continued need for tryptophan. Keep us posted please
Hi,
I started taking L tryptophan and I’ve noticed that I sleep better and I’m more relaxed. I was doing some reading on it and I’m finding some contradictions. I read that it should only be taken for up to three weeks, and then I read about people taking it long term. is it okay to take long term? If I stop taking it tomorrow (that’s my three week mark), how long should I wait to take it again? and what to take in the meantime? I’m a bit confused.
Hannah
The 3 week guideline is new to me and not something I have clients do – kindly share a link and I’ll provide feedback
the website is medlineplus.gov. I tried to share the actual link but could not for some reason.
I am experiencing withdrawal from l tryptophan. Can I pay for a consultation with you today?
Sheri
As mentioned in the blog I’m afraid I don’t have an answer on how to taper tryptophan because I have not had any clients experience the need to taper or slowly wean their tryptophan dose or report tapering side-effects similar to those they experienced when tapering off an antidepressant.
I am not available for a consultation at this time so feel free to describe what has been happening (and ideally answer the questions/scenarios I’ve posed on the blog) and I’ll share what insights I can.