Host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution. was interviewed by Dr Lauren Noel, host of Dr Lo radio.
Targeted individual amino acids for eliminating anxiety: practical applications
- Glutamine: how it’s calming and helps with blood sugar balancing
- GABA: how it eases physical tension
- Tryptophan: how it eases anxiety in the head/busy ruminations (and when not to use 5-HTP)
- DPA and tyrosine: how they help you quit the comfort-eating and coffee
- Precautions when using individual amino acids
- Factors that make them more effective and factors that make them less effective
Here are some snippets from our interview:
You’ll hear some practitioners say GABA molecules are too large to cross the blood brain barrier so GABA won’t work or if it does work you must have a leaky blood brain barrier
Some practitioners are talking about and using a “test” for leaky brain called the GABA Challenge which recommends taking1000- 2000 mg of GABA at night. If the blood brain barrier is intact, you supposedly won’t feel any effect from the GABA. If you do feel a change (drowsiness /feeling drunk or even jittery) then you will need to repair your leaky blood brain barrier.
I have not used the GABA Challenge and only recently learned about it but I am concerned with the very high dose of 2000mg of GABA. That is a lot of GABA for most people and I would expect severe drowsiness for most people or even a reverse effect. I find 125mg (in GABA Calm) is a good starting dose for my anxious clients.
I have also seen research indicating that GABA’s relaxing effect may be due to peripheral effects rather than the effect on/in the brain
Here are some of the papers about there being GABA-receptors in peripheral tissues (these are older papers and I’d love to see some newer research).
- “GABA and its receptors are found in a wide range of peripheral tissues, including parts of the peripheral nervous system, endocrine, and non-neural tissues such as smooth muscle and the female reproductive system” (http://www.ncbi.nlm.nih.gov/pubmed/2162457)
- “GABA is widely distributed in endocrine tissues including the pituitary, pancreas, adrenal glands, uterus, ovaries, placenta and testis” (http://www.ncbi.nlm.nih.gov/pubmed/16338174)
Here is the research on oral GABA being a natural relaxant for 13 subjects who crossed a suspended bridge as a stressful stimulus
GABA could work effectively as a natural relaxant and its effects could be seen within 1 hour of its administration to induce relaxation and diminish anxiety.
Here is the research on the stress-reducing effect of chocolate enriched with gamma-aminobutyric acid (GABA) in humans
the participants performed an arithmetic task and those that were given the GABA choc made a quick recovery to the normal state from the stressful state.
It has been reported that ordinary doses of GABA by oral ingestion do not permeate the blood brain barrier. Therefore, it has been considered that GABA may act on the peripheral nervous system of the digestive organs and not the central nervous system
Meme Grant shared her success story with the amazing amino acids (and the pyroluria protocol) in season 1. She had anxiety, had panic attacks, didn’t enjoy speaking in public, had insomnia and was an emotional eater.
- glutamine allowed her to walk past the gluten and dairy free junk foods
- tyrosine helped her flutterby mind, gave her energy, focus and a desire to do things again
- DPA stopped her comfort eating for too much of the “healthy” sweeteners
- Tryptophan stopped her mind talk, got her sleeping through the night for the first time in 11 years and helped reduce the frequency of her panic attacks
- GABA was the best amino acid and how the panic attacks disappeared
- zinc, vitamin B6 and evening primrose oil helped her pyroluria symptoms
Enjoy the bonus audio of my interview with Meme. You’ll be able to hear first-hand from someone who experienced amazing results.
Here is a video of Nicole trying some glutamine for low blood sugar
The questionnaires are also on the blog – amino acid questionnaire and pyroluria questionnaire. Both have many comments that are invaluable.
If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here www.theAnxietySummit.com
Thank you so much for sharing all the important information.
I am suffering from chronic anxiety, constant painful heartburn, dreams ALL night long so, I wake up 3 4 times a night but….the WORST, horrid , embarrasing and apparently rare symptom which is almost ruining my life is called P.G.A.D.S. I finally found a name for this dibiltating condition. I have endured this since October 2012, am forced to take a perscription benzodiazepine (the ONLY thing which gives me any relief) and , I want to stop taking this benzo stuff as the most recient research on this medication shows it to be linked to some very bad health impacts which are apparently accumulative.
I have seen an excellent functional medicine doc, an M.D. homepathic doctor, and at least 7 other medicals and so far have found Nothing to give me my life back!
Is there any Authentic hope for healing for this awful condition?
Thank you for any aid you can offer or suggest.
Dear Demelza
I’m so sorry to hear you’re suffering. This is the first I’ve heard of P.G.A.Ds (sharing a link for others who may not be familiar with this condition http://www.medicalnewstoday.com/articles/249594.php) but hearing that a benzodiazapine gives you relief I’d like to think that GABA may help. I’ll do a bit more research for you and let you know if I find a GABA/P.G.A.Ds connection.
When someone has heartburn I look into food sensitivities especially gluten. And we also look into candida.
When someone has bad dreams I look into low vitamin B6 and pyroluria, especially when there is anxiety and social anxiety.
Be sure listen to Dr Prouky’s interview on Wednesday and here is a link to the interview I did in season 1 with Catherine Pittman https://www.everywomanover29.com/blog/anxiety-summit-benzodiazepines-risks-vs-benefits/
Trudy
Hi Demelza
A colleague, Jessica Drummond at http://customhormonehealing.com shared that PGAD is something they work with a lot in pelvic floor PT/physical therapy. She says that often, pelvic floor PT can help to relax the pelvic floor muscles and quiet the nerves that are sustaining the PGAD. She also said to look at estrogen levels (is she post-menopausal?), and “leaky bladder” which sometimes relates to oxalates, but is individualized to each person’s gut healing strategies. She has not tried using natural GABA or serotonin support but I have found more studies pointing to benzodiazapines helping so would hope GABA could be helpful. I did also see a few papers that mentioned correlation with prior SSRI use, Paxil in particular, and wonder if you have used any SSRIs in the past?
Trudy
Histamine increases the libido. I would call it “dirty thirties” until I realized that something was wrong with me. I think if you have pelvic inflammation it also will add to it. RO water and Skullcap Tea has really helped my pelvic muscles (Leaky bladder/interstitial cystitis/mast cell disorder).
Hi Demelza
I’m just coming back to find out if using GABA or tryptophan has helped, especially with the P.G.A.Ds. And did you try GABA vaginal suppositories with any success?
And did you get a chance to look into some of the other factors I mentioned? estrogen levels? oxalates? the pyroluria protocol? candida?
I am also curious if you have ever used Paxil as this seems to be a factor
Hi Trudy,
I just wanted to chime in here.
I happened to be listening to you on the fibrofix summit and wanted to check out your recommendations on amino acids.
I am sure you are very busy so I am keeping my fingers crossed you will get a chance to see this!
In any case I too have PGAD and only benzodiazepines help this.
I do have a history of taking ssri’s and snri’s for severe postnatal depression, not paxil, but over time prozac, effexor, lexapro, cymbalta, mirtazapine and benzodiazepines. I would be on one antidepressant and the benzodiazepines at any one time.
When I withdrew from the above I experienced severe withdrawal and nerve pain, not acknowledged by the doctors. My autonomic nervous system went crazy. Symptoms would move around. At times I couldn’t even have the brain power to turn on my pc. My brain wasn’t able to get my.body to do it. It was hell. That was 5 years ago and that took so long to recover somewhat from. 2 years ago I developed PGAD. I have never been right since the withdrawals and have a diagnosis of autonomic nervous system dysfunction.
I was actually hospitalised at a private hospital and had all the nurses meeting about that “poor girl down the hall” because of the crazy symptoms I had.
I also have fibromyalgia and cfs. Had these before the medications but they were worsened by the meds and withdrawal. Plus depression, anxiety, panic attacks, social anxiety (don’t have pyroluria… Was tested earlier this year. Zinc normal but still have high copper)
I am very interested in GABA but it is unavailable in Ireland. I had a functional medicine practitioner prescribe me GABA and l-theanine together (called Zen by allergy research group) which I never took as l-theanine floored me before and I was afraid to take it! And the prescribing doc costs 250euro per session so I simply could not afford him. I still have the Zen in my cupboard. I’m sure it’s out of date soon.
If I could get my hands on GABA what brand would you recommend? And what dose to start off on as my nervous system is so wired.
I’m on 4mg valium at night. I’d rather get off that slowly.
You mentioned in the article above low doses to be effective and that GABA is in the peripheral nervous system. This would make sense that GABA might help and help orally even if it doesn’t cross the blood brain barrier.
What about the suppositories? How would I make them?
Would you recommend tryptophan? I can get this in my local health shop.
I am working with a good nutritionist here, but I would love to hear your opinion as you are quite expert in this area of amino acids.
Also I don’t seem to have any problems with estrogen.
I definitely have pelvic floor dysfunction. Tight but weak pelvic floor. Pelvic floor muscle release helped me years ago. However I do have a fear of that now. I would need to have it sufficiently relaxed first. (maybe GABA can help?)
Demelza, I sincerely hope you have got some relief and.comfort. Pgad is truly awful.
Take care,
Nuala
Nuala
Thanks for sharing – meds can have such an impact on the body.
As long as it’s GABA I haven’t found the brand to be as important – just a clean product from a professional company with no gluten etc. I have sensitive people start with opening a capsule and suing 1/10 of 200mg. I only recommend the Lidtke brand of tryptophan (https://www.everywomanover29.com/blog/amino-acids-pyroluria-supplements/).
As you’re aware the benzo may be contributing to some of the issues you may be having
Great talk today Trudy on the amino acid benefits
Could you comment if there are any contraindications
To taking GABA and or Tryptophan if one has high blood pressure?
Thank you
Hi Sandy
Glad you enjoyed it. I’m sorry, I said I’d post the contraindications and have not done so! I’ll get something up by tomorrow. In the meantime, there is no contraindication with taking GABA and/or tryptophan if one has high blood pressure
Trudy
Hi Trudy, I’ve really been enjoying the summit. You do a great job of asking the right questions, getting clarifications, etc., and I’ve learned a lot. I couldn’t understand which brand of tryptophan you recommended – could you let me know? Thanks!
Hi Ann
Thanks for the feedback. The brand is Lidtke.
Trudy
Could you please let me know if L- Glutamine is not for cancer people.I red few article about since I was taking Glutamine after finish chemo for a while but I stopped after readinf these warning.Shows all are great.I enjoy and make notes.Thank you so much-Daniela
About mercury.I had provocative tests2 time since my heavy metals came out so high and had oral chelation.I learned this was not for me -I am still weak
Hi Daniela
There is conflicting research about glutamine and cancer – some studies say it’s beneficial, other say to avoid it. I’d err on the side of caution and avoid it if you have cancer.
I’m sorry to hear about your mercury issues
Glad you’re enjoying the summit.
Trudy
Hi Trudy,
Very much enjoyed your talk about Amino Acids! I’m confused as to where I find the list of Precautions w/ Individual Aminos. You said they would be on your blog, but I can’t find them. Also, Dr. Christianson’s links to his cookbook doesn’t work…I’ve tried many times. Can u help? Thank u so much!
Karen
Hi Karen
Good stuff! Sorry, I’m a bit behind and will post the precautions tomorrow – look for a link to a new blog post in this blog.
For any issues with gifts like Dr. Christianson’s recipe book please email support@everywomanover29.com and customer support can help
Thanks!
Trudy
Trudy,
I have had an issue with getting flu-like symptoms for the last 20 years whenever I have a social occasion that is about a one-hour + drive away and also every 6 weeks or so even if I am at home. (migrane, vomiting, nausea, complete loss of energy–totally miserable for about 3 days.) About 10 years ago symptoms also included diarrhea. I have removed gluten, eat pretty much organic. Do have allergies to car exhaust and have anxiety issues. 45 years old. No doctor can tell me what is causing this or what I can do to relieve the symptoms. (Taking aspirin at the very earliest sign of symptoms sometimes stops it but I hate to damage my gut taking the aspirin and am looking for something natural. Any ideas what is causing this and how to relieve the symptoms or duration?
I am sorry to hear this and would look into a possible food trigger and keeping a food log to see if you can see some patterns. I’d look for a natural replacement for aspirin (tuermic, ginger etc) and focus on an anti-inflammatory diet.
You may wish to read some of Dr. Sherry Rogers’ books on Environmental Illness and to beef up your liver function, too. Sounds like you are possibly being exposed to something semi-regularly that your body/liver cannot handle. Have you cleared out all toxic cleaners in your home? My hubby also used to get viruses/flu about every six weeks or so and nothing we could find would resolve it. No doctors we saw had a clue until we saw Dr. Les Moore in Pittsford, NY, who is a Naturopath, Acupunturist, Dr. of Oriental Medicine, etc., etc. A product Dr. Moore put hubby on that has helped enormously is a Spagyric Remedy called “Epidemik”by Soluna in Germany. He only takes it now once in awhile, whereas he had to be on it for a couple of months in the beginning. I think the only way you might find Epidemik is through a natural health dr., such as a Naturopath that has a lot of access to products from around the world. Also, sometimes virus symptoms are actually parasites reproducing every so many weeks. You may wish to investigate that avenue, as well, as regular docs rarely even think abt. such possibilities. Best always, Joyce Stotts, Certified Natural Health Professional and 2014 Graduate of the NorthEast Institute of Botanical Medicine (under Dr. Moore).
My husband used to get flu like symptoms that lasted only a day. Then I saw an interview on TV that was about ‘Teflon flu’. I threw out his teflon frying pan and no more of those episodes.
Hi Trudy,
Where can a practitioner learn more about prescribing amino acids? I have your book and Julia Ross’s, and have listened to both your anxiety summits, but would like detailed information on how to prescribe for clients. Thanks!
Hi Kylie
I will be doing some practitioner training in the near future. Please send an email to support@everywomanover29.com to get added to the notification list. I’d love to have you join us. Where are you located? I’m even considering a live 2 day event in the Sacramento area.
Julia Ross does offer her year long certification program too.
PS Just a clarification, as a nutritionist, I don’t prescribe, instead I recommend based on deficiencies
Hi Trudy,
This has been an amazing summit and you have covered so many topics that we would not think would be linked to anxiety. We have struggled with getting help in the medical field for one of our children so we saw a nutropath (but she did not mention targeted amino acids- which type of practitioner would usually do this as we live in England). We have been trying for years to find out the reason for his enuresis. He has had a hair test and an IgG test he is fructose and dairy intolerant and has high mercury and high zinc, low Molybdenum and is a cold child with some sensory difficulties. Is it common for children to have high mercury and he has had not dentistry work? Would your questionnaire be suitable for us to answer about children?
Many thanks Debs
Hi Debs
For kids with high mercury I’d look at prenatal exposure or consumption of high mercury fish or some other exposure like a broken thermometer, or even vaccinations. Keep in mind that high mercury in hair could be a good thing i.e. he is excreting it.
The amino acids can be very effective for kids if they have one of the neurotransmitter deficiencies so yes, I’d suggest doing the questionnaire. Not all naturopaths, nutritionists and integrative practitioners are familiar with the use of targeted indiv amino acids so you may have to educate them. I do offer phone consulting if you’d like to consider that.
I don’t have much experience with enuresis but here are a few less common causes: PANDAs/strep, Lyme disease, sleep apnea, salicylates, oxalates. Of course, anxiety can make things worse so addressing this many help
Trudy
Along with what Trudy is saying about sleep apnea being a cause for the enuresis, I would also add mouth breathing. You don’t have to have sleep apnea to have mouth breathing. Apparently, it causes a reduction in CO2 in the bladder. I am looking into this for my 6 yo son who mouth breathes day and night. It’s easy to check too! 🙂
Hi Trudy!
I am enjoying this summit immensely and thus first want to add my deep thanks to you for bringing together so many exciting speakers. I had never heard of anything like this before. I became aware of your summit via newsletters from both Dr. Carolyn Dean and Vital Choice. How could I not sign up? I can honestly say that your summit has already given me hope that life could be worth living again.
I am a biochemist and long time fan of Julia Ross, so I was really excited to hear that you worked at her clinic. I actually thought of her work as soon as I read your summit bio. I now can’t wait for YOUR book to arrive from Amazon.ca!
I heard so many helpful tidbits in your talk that were new to me and I truly wish I could ask you questions for hours! I will narrow it down to a few in this post.
1. Have you ever tried the 100 mg sublingual GABA supplement by Superior Source? It has a trace amount of lactose, but I have no issues with it and I am lactose intolerant. They are ULTRA tiny, dissolve immediately (unlike GABA Calm) and contain nothing but GABA, stevia, natural flavor and the lactose. I switched to this brand from GABA Calm when Source Naturals increased the strength of the peppermint flavor (burns my mouth now!). I just wondered what your professional opinion of Superior Source was, if you have one.
2. What is the mixed GABA supplement that helped you stop waking with pounding heart, etc.? I am interested because all of the ones I am familiar with include higher amounts of GABA than you promote taking per serving.
3. I can’t seem to catch the product name (GABA blood/brain barrier related) you said that Rebecca Robb uses. It sounds like “phenobit”.
4. When you suggest 1-3 tryptophan in the afternoon and at bedtime, I assume you mean capsules of Lidtke which supply 350mg tryptophan each?
5. I used to source tryptophan from Julia Ross (mid to late 2000’s) before she switched to Lidtke. The Lidtke has many other ingredients other than tryptophan. How can you tell if a sensitive patient is having a negative reaction to the tryptophan or one of the other actives? I personally dislike the extra B’s in many mixed supplement. B’s make me hyper if taken later in the day. It makes it much more difficult to chose a B complex as well. I do love Lidtke in general.
6. How high would you suggest going in tryptophan dosage before adding melatonin for sleep? Should that be based on finding the “sweet spot” for tryptophan with relation to mood/cravings without regard for sleep? Would you ever suggest melatonin without using tryptophan at all? If someone had purely physical anxiety (GABA) and significant insomnia, I wondered if tryptophan would still be your first choice for the sleep.
7. You mentioned that you have recently started looking more closely at genetic factors, especially MTHFR mutations. No physician here in Ontario, Canada would ever do genetic testing for me, but I have been thinking of investing in a service such as 23andme.com
Do you find knowing for sure whether a patient has the pathogenic chromosome mutations for things like MTHFR, inhibited CYP450 metabolism, celiac predisposition, etc. helpful in tailoring a treatment protocol?
I have a more personal question, but will post it separately. Thanks in advance for taking the time to answer my questions.
Best,
Deb
Hi Deb
Thanks for all your kind words! Great questions….here goes
1. 100 mg sublingual GABA supplement by Superior Source? Looks good – thanks for introducing me to a new product. Do you find it works as well as GABA Calm for physical tension? What about the stevia aftertaste?
2. Country Life GABA relaxer
3. Phenibut http://www.ncbi.nlm.nih.gov/pubmed/11830761. This is the study that concerned me http://www.ncbi.nlm.nih.gov/pubmed/23391959. This paper says it affects dopamine levels and has no effect on GABA http://www.ncbi.nlm.nih.gov/pubmed/19334514. But Rebecca Robb has great results and it’s part of some popular supplements (Kavinace is one of them). But right now I’m erring on the side of caution.
4. The starting dose of tryptophan is 500mg, with 1 afternoon and bedtime, going up to 3 each time.
5. I use the Lidtke 500mg tryptophan that only contains tryptophan. They also carry a Tryptophan Complete which I don’t use
6. I typically don’t have someone take more than 3 x 500mg tryptophan at bedtime. Ocassionally, I’ll have someone take more assuming we’re seeing improvements as we go up. We may do a trial with melatonin too. Each person is different. If someone had purely physical anxiety (GABA) and significant insomnia, I would start with GABA and also look at high cortisol.
7. I like the 23andme panel and find it useful in knowing what underling genetic mutations like MTHFR, COMT and others
Great questions!
What a fabulous interview Trudy – I was riveted and furiously making notes as you rattled out sentence upon sentence packed full of vital information! This is a topic which really resonates with me and I am desperate to learn more. I love the way you describe the practical application of the amino acids and think your questionnaire is such a good way to identify which neurotransmitters are lacking. I was wondering whether you might be able to recommend a practitioner in South Africa who does this type of diagnosis and treatment or whether you might be willing to consult from a distance, because all the doctors I have been to so far have been very reluctant to test for the things I am asking for and are very dismissive of the use of these substances to treat anxiety and depression. New regulations have recently seen amino acids such as GABA and 5HTP disappear off the shelves and they can now only be prescribed by doctors who think that they don’t work for these conditions! It is so frustrating – I feel like my hands are tied! For years now I have had relief from supplementing 5HTP – without it I feel completely irrational, but the doctor would put me on Cilift instead – I am terrified of taking anti-depressants because I know that they are so hard to come off of again and there are so many side-effects – and why should I, when I know that the 5HTP works?
Hi Lee-Anne
So pleased you enjoyed it! Yes when I was back in Durban in August /Sept I heard how many supplements are being removed from health stores – not good! especially when you have found something that works for you! I don’t know of anyone in South Africa but would be happy to do a long-distance consult to help. Please email support@everywomanover29.com and we’ll get you the information
Enjoy the rest of the summit!
Trudy
Hello Trudy. I felt like you were talking to me. I need to get of the gluten and sugar. I try everyday. Now i have hope again. When I try with the amazing amino acids i will let you know how it goes. Thank you so much . Also please help me with a plan on how i can detox. As i heard in previous talks that one has to be cautious when breastfeeding. My baby is nine months. I have terrible eczema and feel sluggish..sounds like a liver detox will help. I had this problem a few years ago and detox helped. Somehow back then i was able to go gluten free for a while. Unfortunately i went back on gluten and the harder i try the harder it gets to quit gluten. How can i detox? Thank you Trudy for a super ‘show’
Hi Fathima
I’m so thrilled you have hope! Please let me know how getting off sugar and gluten goes with the amazing amino acids.
If you are still breastfeeding please be aware that the amino acids have not been studied for use. I would also recommend no detox while breast-feeding.
Trudy
Thanks for the Summit and all your hard work & time put into getting us such great information! Could you please tell me the name of the brand of tryptophan you said you prefer? I didn’t understand what you said to know how to spell it correctly 🙂 Thanks!!
Hi Sarah
You’re welcome – the brand is Lidtke. It’s one of the many professional grade products I carry in my online supplement store
Trudy
Hi Trudy,
Thank u again for your excellent talk on amino acids! I have 2 questions.
l. My husband’s M.D. wants to test his neurotransmitters thru Pharmasan Labs using saliva & urine. Have u or Julia ever used this test & do u have any opinion of its accuracy? I remember in your talk u said u did not like the saliva tests & like your questionnaire instead. I didn’t know if u were referring to this particular test.
2. Will u still be able to make available the Precautions List for taking the aminos?
Thank u so much for this awesome summit! I have a feeling I will be needing your 1-on-1 consultation!
Karen B.
Hi Karen
I do not do urinary neurotransmitter testing and explain why here https://www.everywomanover29.com/blog/urinary-neurotransmitter-testing-falls-short/ Julia Ross doesn’t use it either. There is no problem with salivary cortisol testing though and I use this a lot
The precautions have been added to the above blog – sorry about the delay.
Trudy
Hi Trudy,
I am a Mental Health Clinician working in Solano County, CA. I am a huge fan of yours and the work you do to support people in reducing anxiety, mood disorders, and cravings. I have listened to all your webinars on Hawthorn University’s website and have always been fascinated with the connection between nutrition and mental health.
I am eagerly trying to find a practitioner to refer my clients to for nutritional intervention. I currently work with children 0-5 and their families. These children have significant disruptive behavior, anxiety, mood disorders, and are at risk of being dropped from their preschool programs due to their behavior. In addition, parents are desperate, frustrated, and some are considering psychiatric medication in order to do whatever it takes. I do my best to increase families’ awareness about nutritional intervention, but I would like to feel more empowered to know of actual practitioners I can refer them to that will use amino acids and other interventions to holistically address their mood issues.
Are you currently taking new patients? Are there any practitioners you are aware of in my area? Any referrals or information you can provide would be much appreciated.
Thank you!
Jennifer
Hi Jennifer
Thanks for your kind words! I’m so pleased to hear you’re fascinated with the connection between nutrition and mental health. This is so important with the population you work with! Dr Felice Jacka has published a number of studies in this area.
I do work more with teens and older women but would be happy to help if I can. I do work with folks over the phone and you’re not too far from me – people could come up from the Bay area for the first appointment and then we can work over the phone after that. And I can also help you try and find someone locally.
Lets connect after the summit is over.
Trudy
What a great summit and presenters! I am glad I stumbled upon it. I had some tradefybin my life in the last few years . I started some ssris last year and then my doctor doubled the dose. This led to many side effects and then he had me stop it. She said the dose was low enough where I didn’t need to ween and she gave me benzos for the panic attacks the withdrawl was causing. What a mess! She didn’t him it could be ssri withdrawl, remove my iud which sent me in to hormornal imbalance and began testing for things like MS etc which led to health anxiety. Since then I have switched docs, gone gluten free because the withdrawl caused a 30 lbs weight loss. I also started back on 10 mg prozac. I would like to now ween off that and continue to be gluten free and include more organics. To ween off safely would you reccommned taking a supplement such as GABA? Or a different Amino acid and if so which brand do you suggest? Thanks so much for keeping me motivated after this long ordeal.
Hi Chrissy
I’m sorry to hear all you’ve been through! glad you’re enjoying the summit and feeling motivated!
I would suggest doing the amino acid questionnaire to see where you may be deficient and then doing a trial of amino acids.
When someone is low GABA, I like Source Naturals GABA Calm. When someone is low serotonin I like Lidtke tryptophan. I have my clients discuss with their doctor before taking both the SSRI and tryptophan. You can read the amino precautions in the link above.
Trudy
Dear Trudy,
should I be taking my vitamin C and amino acids a different times in the day so as not to wash out my amino acids with vitamin C? How does time released vitamin C playing to this?
Thanks
Jennifer
Hi Jennifer
I have my clients do vitamin C with meals (non time-released) and amino acids between meals. I would imagine time-released vitamin C would impact the effectiveness of the aminos but I have not had anyone use this form.
Trudy
What is the difference between DLPA and DPA? Is one better than the other? You talked about too much 5htp can be a problem. What symptoms can it cause if you get too much? Are you just sleepy?
Hi Jen
Both boost endorphins with DPA doing a better job. With DLPA some is converted to tyrosine (which can be stimulating for some people) and less to raise endorphins. I only use DPA with my clients who need an endorphin boost.
Too much 5-HTP could do 3 things (1) cause a reverse effect i.e the same as too little (so all the low serotonin symptoms – anxiety, worry, depressed etc) (2) make you feel too sleepy OR (3) if you have high cortisol is can raise this and make you feel more wired-tired.
Trudy
What an amazing line up of speakers and experts Trudy – you are truly making a difference to so many people out there who just need some information and support to help them manage their anxiety – well done!
This is fabulous information and I know it will be helpful and life-changing for so many people, Trudy.
Do you recommend a source in the US for getting a proper spectrum light for helping with serotonin?
Karin
Full Spectrum Solutions is a great resource
Trudy
Hi Trudy! Great, great blog with incredibly useful information. What do you recommend most for someone dealing with cancer?
Hi Tandy
If someone has cancer and is anxious, everything that I teach (real whole food, breakfast, aminos etc) will also apply. Certain amino acids may be contraindicated – no tyrosine in melanoma and glutamine has research in favor of it and against it.
For the cancer itself I refer to someone who specializes in cancer. Dr Nalini Chilkov is one of my top cancer clinicians.
Trudy
Thanks!
What is the difference between L-Tyrosine and N-Acetyl-Tyrosine? which one is the best?
How about L-Phenylalanine? Is it good for those who has Low Catecholamines or Low Endorphin?
Joao
N-Acetyl-Tyrosine is considered a more bioavailable form of tyrosine but since I haven’t used it I can’t comment. L-Phenylalanine can help with low catecholamines but I prefer tyrosine. DPA or d-phenylalanine is what helps with low endorphins.
Trudy
May I ask why you prefer tyrosine?
Ana
It’s effective, more readily available and has the most research
So glad the Anxiety Summit went well for you Trudy. Looks like a great lineup. I learn so much from you. Thank you.
Thanks Mary Ellen – it’s been fabulous! one of my favorite comments: a beacon of hope!
I think this has finally hit the nail on the head! I have been trying to get help for my son (age 20) who has had mental health issues since age 12. We have exhausted our resources on trying the functional medicine approach this year, but it still hasn’t addressed several of his issues. Recently, he gave up on being gluten-free because his cravings are so intense. He answers “yes” on all the “low catecholamine” questions! If he is on 2 anti-depressants, is it okay to add tyrosine? If so, how much? Is there a brand you prefer?
Thank you for your dedication to getting the message out!
Hi Julie
I’m so pleased this seems to be a solution for your son. Some antidepressants are SRNIs and work on serotonin and dopamine. Tyrosine could potentially be an issue with an SRNI but I have not seen it to be in my practice. Any brand is fine.
A few other things to consider and possibly address when someone scores high on “low catecholamines” – the adrenals and thyroid. With intense cravings I also always consider candida (Dr. Mikell Parson’s interview on this topic was excellent https://www.everywomanover29.com/blog/conquering-yeastie-beasties-candida/)
Trudy
Wow! It’s amazing how individual people can respond so differently to the various amino acids. I can feel a positive difference almost immediately when I take GABA (thanks for reminding me of this awesome tool that I haven’t use for a while!) My biggest takeaway is to be persistent in figuring out what works best for you.
Thanks, Trudy!
PJ
—–
PJ Van Hulle
Executive Director
Real Prosperity, Inc.
“Have Fun. Do Good. Make Money.”
Hi PJ
Yes, we are all so unique and have to figure out what will work for us. It’s good to hear that GABA works for you – thanks for sharing.
Trudy
Trudy,
I am constantly amazed at all the knowledge you have and share. I recently recommended your book to a friend who is having some anxiety issues.
Thanks for doing what you do.
Write on!~
Lisa
thanks for doing that Lisa! I appreciate you!
Hi Trudy,
I use GABA on my dogs and it has made a huge difference. One is an anxious barker, and barks explosively if even a tiny dog is anywhere on our block. The other is very aloof (not interested in people, I think due to how he was treated before we got him) and is very reactive to many stimuli (anything that beeps, cars parking, anyone walking by, etc). The barker has become a lot less barky, and the other one is more affectionate and interested in people AND less reactive. It’s been great. Michele
Hi Michele
Thanks for sharing and how wonderful for your doggies. We obviously have a great example here of oral GABA having a positive effect.
If you don’t mind I would love you to share the size of your dogs and the amount of GABA you give them? and the form: straight GABA or pharmaGABA? how do you give it to them – open the capsule? in food?
Trudy
Calvin, the anxious barker, is about 45 pounds and 7 years old. We give him 500 mg in the morning and again at night with his regular food. Danny, the reactive one, is 70 pounds and 8 years old. We give him 1,000 mg in the morning and again at night also with his food. I haven’t seen any studies or recommendations on dosing for dogs, so we took a guess at the dose based on the ideas that while they weigh less than people, their GI tracts are shorter so they would likely absorb less. We open the capsule and sprinkle the powder on the food and there’s never been a problem with either of them eating it. I think it’s just regular GABA – I buy it at a health food store or order online from Amazon.
Michele
Thanks for sharing these details! Again, it’s wonderful to hear they are getting results. I’m sure this info will help so many help their anxious dogs.
Just a FYI – individual amino acids are most effective when taken away from protein (so they don’t compete for absorption with all the other amino acids in the protein). If you did this, you’ll likely be able to have the dogs take lower amounts.
One more thing – there is a natural product used by vets for anxious cats and dogs – it’s called Anxitane and is actually just theanine, a calming amino acid that works in a similar way that GABA does. I do find GABA to be more effective with my clients.
Trudy
Thanks for the additional information! Great stuff.
What is the GABA calm you use? Is it by source naturals?
Yes Jennifer – Source Naturals GABA Calm
Trudy,
This has been such a successful event you must
feel great about being able to help so many people.
Clearly the need exists – are you planning more of these?
Yes Mitch – season 3 is in the planning stages
This is such an amazing thing. I love how the amino acids can be so supportive and helpful. It’s really wild how sometimes just a little can have such a powerful effect. You are truly doing wonderful work helping people to feel their best. Thank you Trudy.
Thanks Mira – you’re so right – they can have such a powerful effect
I finally figured out how to post on this blog (lol) so here goes….I sat through most of The Anxiety Summit 2. If I couldn’t listen to the speaker of the day, I tried to listen to the recordings. My Dad was diagnosed with anxiety/ depression disorder 13 yrs ago. He was put on SSRI’s. He did ok with them up until spring of this year. His anxiety was so bad he did 2 stints at 2 separate psych hospitals(6 months total). All the SSRI’s on the market couldn’t help my Dad, but that’s the protocol the medical Dr’s followed, more drugs. I was getting infuriated with how they were going about his treatment. He was getting worse by the minute. This has turned into a disease within his mind and body. He needed healing, not more drugs to cover up what was going on within him. I started him on Gaba Calm. 1 125 mg tablet to start and added more as the weeks went on. His mind is finally calming down. I am going to add tyrosine to help get his mojo going. He is still on SSRI’s, but we have started to cut his dosages back slightly with the help of an awesome Nutritionalist in our area. I have done extensive research on depression/ anxiety disorder. My Dad is 70 yrs old. It’s been a struggle to get him to change a mind-set that has been there for so many years. Diet, exercise, supplements. All things that are truly important for him to heal. He is finally coming around, since he see’s that the medical Dr’s are just pill pushers and that’s it. He is doing a lot better, but still lays down a lot on the couch. The gloominess in our part of the country in the winter months is enough to want anyone to lay down on the couch,but I make him get up and try to do things. He’s lost his zest in life. All I want is my Dad back. At this point, I will continue to fight for him because he has no fight left. Acupuncture is next. This technique could possibly open up some channels in his body that he so badly needs opened. I will continue with the Amino Acid Therapy until we reach the desired affect. It’s done wonders for him so far. My question is should I be giving him a certain B vitamin to help with the GABA? He’s on a whole food B-Complex only right now. Thank You Trudy for what you bring to this world!
Hi Laurie
I’m so glad you’re finding answers for your dad. It’s truly wonderful that he has responded to GABA Calm so well.
Keep in mind that GABA Calm is only 125mg and some people do better on higher amounts – like 500mg a few times a day. I do like my clients to open the capsule and hold it in the mouth (at least initially to see if it’s more effective this way).
I also like to calm my clients down before adding in tyrosine as this can be too stimulating for some – at least while they are still battling with anxiety.
If he was my client I would focus on (1) blood sugar balancing (glutamine, breakfast with protein etc) and then (2) serotonin support (assuming he has low serotonin symptoms). And get the ok from the doctor to add tryptophan 6 hours apart from the SSRI. I’d add in a good 50-100mg B complex (the whole food B complex may not be enough) and possibly extra zinc and vitamin B6. I’d also add a good multi (with no copper if he has pyroluria symptoms).
And don’t forget about full spectrum lights – they do wonders for serotonin boosting, especially when it’s gloomy. And the dietary aspects go without saying – real food, grass-fed red meat, wild fish, pastured eggs/chickens, healthy fats, no sugar/caffeine/gluten/alcohol. I’m sure your nutritionist is helping with all of this + optimizing digestion and addressing gut health.
Your dad is very fortunate to have you and I’m glad he’s coming around to this approach. Thank you for sharing – you’ll get your dad back!
Trudy
Thank You so much for your great advice. I believe in my heart my Dad will become much healthier in the new year!
Laurie
Dear Trudy,
What would you recommend as a good brand name for Melatonin as well as good brand of 5-HTP for my sleeping problems. What would be the starting dosis.
or L-Triptophan I remember you mention Lipke right? And when to use GABA instead of L-Triptophan and vice versa.
Would it be OK to take Melatonin, plus LTriptophan plus 5-HTP for sleeping disorders?
I apologize for all these questions.
Kind regards,
Aluizio
Dear Trudy, What would you recommend as a good brand name for Melatonin as well as good brand of 5-HTP for my sleeping problems. What would be the starting dosis. or L-Triptophan I remember you mention Lipke right? And when to use GABA instead of L-Triptophan and vice versa. Would it be OK to take Melatonin, plus LTriptophan plus 5-HTP for sleeping disorders? I apologize for all these questions. Kind regards, Aluizio
Dear Aluizio
The starting dose for tryptophan is 500mg and I only recommend the Lidtke brand. Tryptophan is for low serotonin i.e. ruminating thoughts and worry/anxiety in the head and GABA is for physical anxiety. I suggest doing the questionnaire to see where you fall.
I typically start my clients on tryptophan and then add melatonin later if needed. 5-HTP can raise cortisol so I would also use that if cortisol is not high (based on adrenal saliva testing).
As with all supplements I recommend professional grade products with no additives, no gluten etc
Trudy
Hi Trudy, i started using tryptophan while being on paxil. I didn’t feel good. i was not sure what to do, so i stopped tryptophan, but what about gaba, can i take that safely with tryptophan. and do you know of anybody that can work with me in central oregon. I don’t have insurance and i am not working at the time. I have been on and off paxil for many years. Just started with nutrithyroid today, but it had side effects on me like jittery, tired, fuzzy head, and tingly on my face. but it went away like after lunch. I need some hope. also having adrenal fatigue and mthfr hetero. i am not sure how b6 will go for me. I also have hashimotos and i am currently seeing a functional nurse practitioner. Thank you so very much. God bless you.
Mirta
Hi Mirtha
I think you’re asking if you can safely take GABA with paxil? If I was working with you and you had low GABA symptoms I’d have you do a GABA trial and start really low – around 100mg. If you do also had low serotonin symptoms I’d have you reconsider a tryptophan do-over with a very small amount – also 100mg (ie open the capsule and do a few dabs), 6 hours apart from the paxil and only the Lidtke brand of tryptophan. And then if you still didn’t feel good with tryptophan, do a 5-HTP trial (also with a small amount). All of this would be done with the approval of your prescribing doctor.
I’m not familiar with Nutrithyoid but see it’s a thyroid glandular and it may have just been too much. I also see it has some dubious looking ingredients on the coating (polyvinyl alcohol, talc, polyethelene glycol, polysorbate) and those ingredients may also be a contributing factor to the jittery feeling etc.
I don’t know of a practitioner in Central Oregon but Izabella’s Wentz’s book “The Root Cause” is a great Hashimoto’s resource. If you don’t yet have my book “The Antianxiety Food Solution” it’s a great resource for anxiety and the aminos in particular.
Trudy
Hi Trudy
i have looked at the questionnaire and think that both gaba and serotonin could both be something I’m deficient in, you recommend the source naturals gaba calm but i can’t seem to get it on the english amazon?
Hi Martyn
I would suggest doing a trial of one of each (GABA and tryptophan) and see how you do. Vitacost sells Source Naturals GABA Calm and they ship to UK.
Trudy
also trudy….
is there specific test i could take in england to see what I’m deficient in?
Martyn
I use the amino acid questionnaire and response to the amino acids. I don’t do neurotransmitter testing
Trudy
I came across you’re website on FB. I’ve been suffering from anxiety since my son was diagnosed with Leikemia In 2009. He successfully completed his treatment but since thence mind is consumed with constant negative thoughts about my his health and my health. It seems to get worse at the same time every year from November to about February. Mostly during the Luteal phase of my menstrual cycle the anxiety skyrockets until about two days after my period ends. Then I’m happy and I have control of mind for about 1-2 weeks out of every month
Hi Diana
I am sorry to hear about your son and hope he is doing well. Going through something like this is very very stressful. It could have affected your adrenals (similar to PTSD) and in turn affected your sex hormones leading to really bad PMS. The fact that it’s worst November to February (assuming you’re in the northern hemisphere) could be due to low serotonin and the winter blues or SAD.
The good thing is that you have identified a pattern. If you were my client I’d focus on boosting serotonin as this may help the seasonal/winter aspect and have an impact on hormones and help the worry/ruminating thoughts. Tryptophan, 5-HTP and light therapy are all options.
I’d also consider low GABA if you have physical anxiety – this helps with raising progesterone too.
I often find that my clients with hormonal imbalances also do very well on the pyroluria protocol (zinc, vitamin B6 and evening primrose oil). It’s helps social anxiety, inner tension, helps to balance the sex hormones and helps to make brain chemicals.
This is all spelled out in detail in my book and I’d be happy to help one-on-one if needed.
Trudy
thanks for your help trudy
Hi Trudy – I started taking Litke’s Tryptophan after hearing you talk about it in the Anxiety Summit, and the skin on my face started to feel like sandpaper about a couple of weeks into taking it. I stopped taking it and it got better. I would like to try it again to see if it was just a coincidence, but thought I would get your input first. Have you seen this “side-effect” of tryptophan before? I was taking 1-3 caps/afternoon of the 500mg caps.
Thanks for your help!
Hi Sarah
I have not heard of this effect from tryptophan. You were wise to stop. A few questions – what brand? and were you seeing any benefits? why 1-3?
Trudy
I was taking the tryptophan from Lidtke. I took 1-3 caps as I thought that was the dosage you said to work up to each afternoon/evening. I can’t remember specifically the results as it was a few months ago now. I have two large bottles of it, so I will probably try again. Maybe I should just stick with 1 of the 500mg capsules a day (?). I’ve been doing some online searches for this dry facial skin “side-effect” too and have not found anything. I love using myself as a guinea pig so I will probably try again 🙂 I really appreciate your input! Thanks!!
Thanks for coming back and commenting Sarah. I’m sharing this because it may be related – it’s a comment from another blog post https://www.everywomanover29.com/blog/urinary-neurotransmitter-testing-falls-short/
“I just started taking Source Naturals L-tryptophan the past 2 nights (1,000 mg). This morning I woke up feeling like something was biting my feet (itchy). I RARELY get bitten; plus my feet were covered up, no bedbugs etc. could it be an allergic reaction?”
And someone else just mentioned on facebook that she thinks she may be having a reaction to the vegetable stearic acid (from palm oil) in the Lidtke tryptophan. Lidtke does make a powder that is only tryptophan so this may be worth trying so you can rule out if it’s the tryptophan or not. Be warned, tryptophan does not taste good so could be mixed with mashed banana.
Trudy
Can tryptophan also be taken in the morning for anxious thoughts in addition to mid afternoon and bedtime?
Hi Sharon
Yes tryptophan can also be taken in the morning for anxious thoughts in addition to mid afternoon and bedtime. I have my clients start low and build up and watch for it making them too tired – if they do feel tired but do see benefits then I’ll have them try 5-HTP (if they don’t have high cortisol at those times).
The reminder that tryptophan/5-HTP should not be taken within 6 hours of a SSRI and you’d want to check with your doctor first if you are on an SSRI
Trudy
Thanks Trudy. I’m not on any SSRI as I tend to have low sodium. Can tryptophan be taken at the same time as GABA Calm?
Yes they can. I recommend starting with one and getting a feel for how it’s working and then adding the other one.
Hi Trudy, I’ve been experience really nervous stomach lately, no changes to diet, I avoid gluten & sugar, on tests my B6, Zinc and other things are sometimes slightly low so I supplement them. I struggle with candida and mercury which I detox safely and I use probiotics. Could this be related to magnesium? I also get brain fog and trouble sleeping, parasite? I’m confused please help me x
Hi David
When I hear nervous stomach I think of a few things – one is dysbiosis. The dysbiosis could be related to candida or even parasites (which can affect sleep and cause brain fog). Switching to a new probiotic may help and /or adding probiotic-rich foods.
We also make brain chemicals in our gut and low serotonin could well be a factor. Trouble sleeping is common with low serotonin. Have you done the low serotonin questionnaire and tried tryptophan?
Trudy
Hi Trudy
Do you believe in the serotonin hypothesis?
That low serotonin is a factor in anxiety and/or depression?
All the best
Anna
Hi Anna
Yes, I do believe that low serotonin MAY be a factor in anxiety and/or depression. I say MAY because it’s one of many possible causes – low serotonin, blood sugar instability, poor diet, not enough protein, sugar, caffeine, gluten, low dopamine (for depression), pyroluria, inflammation etc.
There is much evidence supporting low serotonin and depression/anxiety and I plan to write a whole article on this. For starters here are a few recent papers:
A 2015 paper: “These findings suggest that the anxiolytic effect of dark cycle restraint is mediated by corticosterone, serotonin or γ-aminobutyric acid-independent mechanisms” http://www.ncbi.nlm.nih.gov/pubmed/25687845
Another 2015 paper: “Our results demonstrate that 5-HT [serotonin] deficiency leads to increased susceptibility to social defeat stress (SDS), a model of psychosocial stress” http://www.ncbi.nlm.nih.gov/pubmed/25675490
And one more “These findings link the serotonin transporter gene to affective circuitry findings in anxiety and depression psychopathology” http://www.ncbi.nlm.nih.gov/pubmed/25675343
Of course, seeing the very positive responses of my clients to tryptophan and/or 5-HTP (and even light therapy and exercise) when they score high on the low serotonin question, is also a big factor.
Stay tuned for a longer article in the near future.
I’d love to hear why you ask this question and what insights or questions you have. I’d be happy to address them in the new article.
Trudy
Hi Trudy
Thank you for your answer and the articles. You say that There is much evidence supporting low serotonin and depression/anxiety.
But there is no test you can take today that show low serotonin in the brain? So where is the evidence? The serotonin hypothesis is a sales pitch from the pharmaceutical industry to sell psychotropic drugs. It is therefore very worrying that nutritional therapists found a market for sufferers and medicine addicts! Please read Robert Whitaker, Peter Breggin and David Healy’s books. Please read: http://www.madinamerica.com/2012/09/things-your-doctor-should-tell-you-about-antidepressants/
http://youtu.be/ARZ2Wv2BoFs (Dr. Peter Breggin video)
Hi Anna
Thanks for sharing the great article from Mad in America – I totally support this fact that “antidepressant medications appear to do more harm than good as treatments for depression” and all the “harmful effects on other processes in the body” like digestion, sexual function, cognition etc.
I also respect Dr Peter Breggin’s concerns (in the youtube video) about biochemical imbalances in your brain being caused by the antidepressant drugs you are taking (such as Prozac or Paxil) and why we want to avoid them. Unfortunately anxiety and depression is not only caused by life stresses and trauma – there are biochemical imbalances, nutritional deficiencies, gut problems, food sensitivities, heavy metals (and many more…too many to list) that may be factors.
Low serotonin is just one of these possible contributing factors and we can address this with dietary changes (real whole food, grass-fed red meat, no sugar, no gluten, oily fish, healthy fats), amino acids like tryptophan and 5-HTP, zinc, light therapy and exercise.
Finally, you can actually test serotonin levels via platelet testing. It’s the test that correlates most closely with CSF levels.
Trudy
Hi Trudy,
I was enlightened on amino acids through your webinar last year. It was fantastic. It gave me the courage to take my daughter off half her medications so far. She is still on a benzo and an SSRI. I hope to get her them off within the year.
I find your comment that serotonin levels can be tested via platelet testing interesting.
My daughter has platelet testing every 3-6 months because of a low count. The psychiatrist feels the low platelets are a side effect from an SSRI. I put her on 5htp and taurine. Will the platelets raise to a more normal range as the serotonin normalizes? The levels have flexuated with the SSRI. Thank you for sharing your knowledge with us.
Hi Linda
How wonderful to hear you were enlightened last year! Regarding your platelet question – what I was referring to is testing of serotonin the the platelets. A lab called European Laboratory of Nutrients (ELN)/formerly Vitamin Diagnostics offers this test http://www.europeanlaboratory.nl/documents/%20BIOGENE_AMINES_ENG.pdf)
This is different from the platelet test your psychiatrist is testing. I’m not aware of a low platelet/SSRI connection but do know that low platelets can indicate lowered immunity.
I assume your daughter’s psychiatrist is aware she is on taurine and 5-HTP too? You always wants to keep the doctor informed/get their approval
Trudy
A close friend of mine has a little 5yr old boy who is celiac. Since his Dx, he’s doing much better but they’re struggling to get it out of his diet 100% – he keeps getting “glutened” as she calls it by well-meaning but uneducated parents of his friends, his chess coach, etc. and he’s VERY sensitive to even the slightest exposure. He takes a good 3-4 weeks to recover psychologically every time he’s exposed.
She recently started supplementing him with the supplement SeroPlus (maybe you know it?) which has 5HTP in it. She gave it to him last week when he got “glutened” and noticed his temperament was SO much better than usual. So she’s kept him on it But she’s worried about him developing a dependance on supplemental serotonin in this way.
My instinct is that he won’t develop a dependance because she’s giving him the precursor, and this is so important while his body and specifically, gut, heals. But I wanted to ask you since you’re the pro in these matters. What’s your experience been?
Hi Margaret
I’ve not used Seroplus (http://www.pureencapsulations.com/seroplus.html – link here for other readers) but it looks good and the positive result is always a good thing! You’re right and I agree, I don’t see dependence as being an issue – we know gluten issues can lead to low serotonin so his continued consumption of gluten may be continually depleting his levels, plus his gut needs to heal.
One issue longer term may be that his gluten exposure may very likely have impacted his adrenals and 5-HTP can raise cortisol which won’t be good if his cortisol is high. This is why in adults I use tryptophan unless I know cortisol results. In kids I always only use tryptophan since it’s closer to food. And I do like to use an individual amino acid vs a combo product as it’s easier to increase and/or decrease just the amino acid. And mom may need to reduce the amount as his gut heals and his serotonin levels come up so you don’t get a reverse effect (too much of any amino can do this).
One more thing to consider is methylation and SNPs – detox is compromised with the MTHFR polymorphisms and this product has 500mcg of folate (the good form!) which may be contributing to his good temperament too. Also if he does have either of the MTHFR mutations it may end up being too much folate if he is given more capsules (hence the benefit of individual amino acids and even individual folate).
I’m sure they are doing all they can to prevent this but would like to suggest this in case…I’d also suggest a card with information on how deadly gluten is to this little guy and really making a point to educate everyone he’s going to be in contact with. I’m sure he’s also old enough to ask smart questions as I’m sure he’s well aware of the effects. It just breaks my heart to hear he keeps getting “glutened” !
Thanks for asking – great question I plan to use in an Ask Trudy blog post
Trudy
Hi Trudy – What is opinion/experience using 5HTP with tyrosine to boost serotonin and dopamine with depression and binge eating? This person is all ready on two antidepressants + Abilify. Combo not working well. Binge eating going on decades. Would it be a safe trial to try 5HTP (100 mg) and tryrosine (1000 mg) up to 3X/day max 2-3 hours away from antidepressants? 5HTP is more affordable than tryptophan. Cost is factor for her. Of course her doc internist needs to be in on discussion. Thoughts?
Hi Molly
I have not had someone on two SSRIs use tryptophan or 5-HTP. I learned this from Julia Ross. If they were on one, I’d have them do the low serotonin questionnaire and if they score high I’d have them do tryptophan firstt – 6 hours from the SSRI (i.e take SSRI in AM and tryptophan in afternoon/evening, with doctor’s ok) – starting with 500mg I get better results with tryptophan but some people do better on 5-HTP so that would be fine to start with (starting with 50mg). If they score high on low catecholamines then I’d start with 500mg tyrosine and go up – unless one of the antidepressants is SNRI. There is no one size fits all and I have not found the 10:1 tyrosine to 5-HTP ratio to be relevant. I think that is what you are referring to.
I would consider a trial of glutamine (for intense sugar cravings), DPA (for comfort eating/reward eating and often helpful when binge eating is an issue + helps low mood) and/or GABA (for stress eating and anxiety).
And of course I’d address the basics like real food, quality protein, breakfast, candida, low zinc etc
Trudy
Thanks Trudy. Makes sense. Also makes sense to look at SSRI vs. SNRI. I think her mix includes both. Start low and slow and talk with her doc for sure. Thanks again.
Hi Trudy,
What is the brand you use for GABA supplementation, and same for 5HTP. I got the LIDTKE recommendation for the tryptophan. Great talk on the Mental Wellness Summit. Loved it!
Ingrid
Ingrid
Glad you enjoyed my talk on the Mental Wellness Summit. The links for some of the GABA products and 5-HTP are here in this blog post https://www.everywomanover29.com/blog/amino-acids-pyroluria-supplements/
I love what you. I have a few questions that perhaps you can help me with.
1) Can you take both tyrosine and DPA?
I don’t really score high in the DPA part on your questionaire, but I did on Julia Ross’ due to the question about it being hard to get over losses and being sensitive.
2) I have been taking 400 mg. 5-HTP but am considering switching to tryptophan. Any tips for making the switch? And how do I know which would be best fo rme?
3) Does vitamin C interfere with amino acids?
Thanks so much for making the world aware of these amino acids.
Rosa
Hi Trudy, I have heard you talking on various weinars and am blown away by your approach. I’m am writing to you as I don’t know where to turn for advise.
I live in Dubai United Arab Emirates . Here it is so very difficult to find holistic Drs , mental health is swept under the carpet!
I am extremely concerned about my 17 year old daughter . She is in her final year of high school studying international Baccalaureate. It is a tremendously stressful time for her. She is very bright, wants to study exercise physiology. She finds work very difficult as she is profoundly dyslexic. The last couple of weeks she has started having panic attacks. A couple of days ago she flunked a very important maths test because panic set in and she ” went blank” despite being very well prepared.
I have done the pyroluria assessment and she seems to tick so many of the boxes.
She eats very healthy, green juice first thing , no dairy, very little gluten. Low carbs and a small amount of organic meat. She is not a typical junk food eating teenager, she is passionate about nutrition and health.
She has just been put on an acne medication as all holistic approaches have failed.
I’m desperate to try to help her, and just don’t know where to turn. I tried to buy your book but no one stocks it here and amazon would not deliver here?!!!! I will try again to get the book.
If I give her GABA what dose should I use? She is very small 47 kg and under 5 feet tall,tiny hands and feet.
She already takes zinc 25 mg, omega 3 magnesium, turmeric vit D3 a B complex pill!!!
Can you suggest any protocol we might be able to follow? I’m desperately worried that she will not achieve her goals by being paralysed by anxiety. She is very determined and tenacious and wants to show everyone that even with a servere learning difficulty you can succeed .
I understand if you are unable to respond I’m sure you get tons of questions on a daily basis, but is did not know who else to reach out to. If I go to a GP they will just write a prescription and that’s not what we want.
Please keep spreading the word about mental health and food etc it is an amazing gift to all.
Many thanks
Jane
Jane
Sorry to hear this. A few things jump out – stress (must be managed), adrenal support, acne medication side-effects, gluten and green juice first thing (protein/healthy fats are key for blood sugar control and anxiety). If I was working with her I’d address the pyroluria too and do amino trials – I like to start with GABA Calm which has 125mg GABA
You should be able to buy the kindle version of my book via Amazon or you can get a PDF/digital version via my publisher – link here https://www.everywomanover29.com/store/aafsbook.html
Trudy, thank you so very much for your reply, I really did not expect a responce! Bless you for that . I will get the book and implement your suggestions. Very interesting about protien and healthy fats for blood sugar control and anxiety. I listened to you yesterday on the pain sumit and have taken notes. Please know that you are helping people all round the world, people who are vulnerable and desperate. I am passionate about natural approaches. Keep up your wonderful work .
You’re so welcome – there is a whole chapter on the topic in my book!
Here is a blog to get started now https://www.everywomanover29.com/blog/low-blood-sugar-can-result-in-anxiety/
My apologies if this is not the correct forum to ask a question, but I have two.
1) can serotonin syndrome happen from taking tryptophan? Or is this a side effects caused only by benzos/SSRI’s?
2) I know someone who takes the tryptophan by LIDTKE. Image had an organic acids urine test done showing her serotonin is low. She says she takes 500-1000mg tryptophan and “her brain vibrates”. Every time. The sensation goes away but she wonders if this is crossing her blood brain barrier and activating a part of her brain that needs it. Is this a rate side effect? Or a common one? Good or bad?
Thank you! We are enjoying the Healthy ME Summit You were great as always!
Tan
1) I don’t know of a case of tryptophan causing serotonin syndrome but too much of any of the aminos (and any nutrient) can cause adverse/opposite effects
2) I’ve not heard of tryptophan causing the feeling that “brain vibrates” but it doesn’t sound good and I have clients stop when they get adverse or weird symptoms
Glad you’re enjoying the Healthy ME Summit
Could you please recommend a good b complex Trudy! I love your book and have just started treating myself for Pyroluria. Do you know of any Doctor in British Columbia Canada?
Deb
So glad you like my book! I like Designs for Health B Supreme. You want something with at least 50mg of the Bs and the activated form of folate and not folic acid.
I’m afraid I don’t but I hope to have a directory of practitioners later this year once I’ve launched the Anxiety Nutrition Institute training classes http://www.anxietynutritioninstitute.com/
In the meantime I encourage you to search this blog which has a wealth of information on pyroluria. It’s also been the topic of a number of interviews on the Anxiety Summits https://www.everywomanover29.com/storemenu.html
I’ve noticed that my pee smells different after l-tyrosine. It’s magical stuff and helped my mood and energy but I don’t know if the smelly pee is something to worry about. I think it smells a bit like asparagus pee (sulfur). It only happens when I take tyrosine. Can you tell me why this happens and more importantly is it a problem???
Robbie
I’ve not had anyone ask this question and don’t honestly know and can’t find information about this.
But glad it’s magical and helped your mood and energy!
I tried googling it and had no luck but as I first heard about it from you I thought you might know!
Thanks
I just started taking kavinace for anxiety (prescribed by my natural dr). After trying to take it a week ago and having bad results.. I decided to start again with a lower dose. I took one last night and felt good earlier today but now feel extremely nauseated/out of it/brain fog and just like I could vomit. I feel this way when trying prescription anti anxiety medications, too. Any advice??
Emmielou
I’m sorry to hear this but I am not a fan of phenibut and write about this here http://www.everywomanover29.com/blog/gaba-for-anxiety-instead-of-phenibut/
I know I’m late to the party, but I just found your website a couple nights ago. I think after feeling terrible for three years, I finally know what is wrong with me and all the weird random symptoms are in fact related (as I have suspected for a long time). Low GABA brought on by long term use of Xanax. Low dose (1 mg) but eight years!!! My GP gave it to me to help me sleep when I told him my brain just won’t shut off at night. I’ve been taking it every night for 8 years. He says “no problem, people can take this like candy.” For years, that’s all I needed. During the day, I was fine. Up until a few years ago, the anxiety ramped up during the day and doesn’t let up all day. I think when the Extended Release Xanax half life is gone, it leaves me crazy anxious cuz It’s depleted my stress management. I’ve fought adding more Xanax during the day; thank god. But it’s been really rough. But I think the since Xanax depletes GABA, that I am probably GABA depleted.;(
Now, I have extreme anxiety, not worried, but stressed out wired, amped up anxiety. For the last year, I’ve wondered if I had fibro cuz the muscle tension has caused terrible muscle spasms in my shoulders and back. I can barely sit still I get so anxious at times. I’ve been experiencing various digestive complaints and pain, pains in strange place (anal pain), Burning Mouth syndrome….
Two nights ago, I come across your Burning mouth blog treatment with GABA and bought your book. Read it today. I found your article on rectal spasms, and thought, oh my God, these are all GABA related, as well as this anxiety and muscle pain.
Why didn’t anybody tell me that Xanax would do this to me? I’m devastated! I was just following my doctors orders. 🙁
So, now I know I need to get off the Xanax which won’t be easy and will take time but I just need to know whether I can start to rebuild my GABA depletion while I’m tapering down my Xanax. First I will work to try to get my own body to make its own GABA. What can I eat to rebuild my GABA levels? I’d like to supplement too, assuming I can take it without making my heart race or anything. I can’t take tyrosine (wires me) but I did buy the enzymatic therapy 250mg GABA. I also bought 200 mg l-theanine. I also bought the tryptophan; I’m not sure about that one yet. Are there any cautions?
Oh Trudy, I hope this is it. I hope I can take the GABA and somehow put my health back on track. Any suggestions would be greatly appreciated.
Heidi
So glad you found my articles and are putting the puzzle pieces together. I have clients use GABA (and other nutrients they may be low in, plus all the dietary and gut approaches covered in my book) while tapering benzos but keep in mind benzo support groups will say no supps at all. I don’t agree with this approach.
Eating quality animal protein and getting all the other nutrients help us make GABA and the other neurotransmitters so follow the steps in the book. The amino acid precautions are listed in the amino acids chapter.
And yes the benzo taper must be done very very slowly. It’s very unfortunate that doctors are not educated in the adverse effects of long-term benzo use