I typically start clients on tryptophan if they have signs of low serotonin: stressed, overwhelmed worry, fears, obsessing, feeling anxious, ruminations, low mood, anger issues/rage, sleep problems, pain issues, PMS, low self-esteem, imposter syndrome, and afternoon/evening carb cravings etc. If we don’t get expected results we switch to 5-HTP as some people do better on one vs the other.
With signs of low GABA – a more physical kind of anxiety, with some overwhelm, intrusive thoughts, tension, sleep issues (often lying awake tense), stress-eating and/or drinking and pain – I typically recommend a GABA only product (as a powder or capsule opened) or GABA Calm (a sublingual). In some cases we may consider theanine and pharmaGABA.
The best way to assess low GABA and low serotonin is the symptoms questionnaire and a trial of the respective amino acids – one at a time. But the key is to find the ideal amount for the unique needs of each person. We do that by methodically and systematically increasing the amino acid slowly and tracking improvements for each increase.
In this blog you can read some success stories from women who used tryptophan and GABA for relaxation, jaw pain, sleep, anger and mood symptoms, and my commentary with some additional insights.
Tryptophan and GABA (as powders) – for her stress and pain
Amy uses both tryptophan and GABA for relaxation and jaw pain:
I use both tryptophan and GABA, I just take them separately. When my jaw was really bad the tryptophan really helped. I also do vagus nerve stimulating exercises that make me yawn and it stretches and releases the jaw.
As for the GABA …when I’m very stressed, I need extra to feel the effects. I use a pinch between the fingers of the Now powder and let it dissolve on my tongue. I feel my body relax in about 30 seconds. If nothing then I take a second pinch. Most days 1 pinch is enough.
I also let tryptophan dissolve in my mouth and most days I feel the same physical relaxation after a few moments. It’s not always obvious with the tryptophan though. I use 1/4 tsp of powder but you can use capsules. I mix the powder with pudding powder because it’s very bitter.
Both tryptophan and GABA can help with pain, and also feeling anxious and stressed.
The benefits are via different mechanisms – tryptophan boosts low serotonin and it’s typically more of a mental type of relaxation. This blog illustrates the use of tryptophan for TMJ (temporomandibular joint) – Tryptophan ends TMJ pain, headaches and worry, and improves mood and sleep: a success story.
The amino acid GABA boots low GABA levels and it provides more of a physical type of relaxation and also helps with pain relief.
I like that Amy is using both amino acids as powder and I’m happy for her. GABA powder tastes pleasant and is much more effective used this way (or capsule opened or sublingual).
Tryptophan can be swallowed but many find it more effective as a powder or capsule opened. As Amy says, it’s very bitter as a powder.
Tryptophan or 5-HTP and different forms of GABA – for sleep, anger and mood symptoms
Kerry tried 5-HTP and pharmaGABA but did better with tryptophan and GABA Calm:
My naturopath had me on 5-HTP but I never felt a benefit, and pharmaGaba was a histamine trigger. After reading your book I tried tryptophan and spent many months on 2 x 500mg at bedtime. This helped with sleep and definitely stopped the surges of anger that happened often.
I read a lady say her staple was 2 x Gaba Calm at bedtime and on rising, so I tried this and it helped.
I now take both tryptophan and Gaba Calm only if I feel niggly mood symptoms.
My previous diet was standard vegetarian, then vegan for several years. I now have lots of protein in the form of beef liver capsules, eggs and protein powder. I don’t like meat.
Kerry shared all this in a recent blog comment, describing how tryptophan and GABA Calm were big game-changers for her, in addition to “a long slow mold detox …addressing nutritional deficiencies and implementing dietary changes.”
Mycotoxins caused by mold, nutritional deficiencies and a poor quality diet can impact neurotransmitter production. The good news is that when you find the right combination of amino acids – in this case tryptophan and GABA Calm – you can get relief right away while the other factors are being addressed. It reduces the overwhelm, stress and fears too.
Kerry’s approach of consistent use of both amino acids is the best way to go and I’m so happy for her. And once levels are sufficient they can be used as needed, provided other underlying causes (like toxins, diet etc) are being addressed.
I will add that some individuals do better on 5-HTP and some do better on tryptophan so it’s often a matter of doing a trial of both. I typically recommend tryptophan to start because 5-HTP can be an issue if cortisol is high.
I also always recommend starting with some forms of GABA because of the potential histamine issues with pharmaGABA. That said, some individuals do tolerate pharamGABA so it’s worth doing a trial of both. And we may also consider theanine when we want to support low GABA, low serotonin and low dopamine.
Theanine and tryptophan and diet/lifestyle changes – and feeling her best!
Luna worked with a health practitioner to taper off Prozac (very slowly) and used amino acids during the taper and afterwards:
As someone who took Prozac for years and eventually came off, please pay special attention to Trudy’s advice to come off it SLOWLY. I’d say do it so slowly it may seem ridiculous.
I tried three times to get off Prozac and it was only with the help of an ND/PharmD did I finally get the info needed to come off it without *awful* side effects. To do it well, the process takes MONTHS – not weeks as many doctors recommend.
These days, I take L-Theanine and L-Tryptophan. And I’m preparing to add some GABA soon. Combined with daily 45 minute walks outside, and a low-sugar/low-gluten diet, I’m doing the best I have in my adult life.
A comprehensive approach that includes amino acids, dietary changes, and getting out in nature can make a world of difference. I love it when I hear feedback like this.
Additional resources when you are new to using tryptophan and GABA and other amino acids as supplements
As always, I use the symptoms questionnaire to figure out if low serotonin or low GABA or other neurotransmitter imbalances may be an issue.
If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.
There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control (this is covered in an entire chapter too), sugar cravings, anxiety and mood issues.
The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.
If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support.
If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.
Wrapping up and your feedback
Now I’d love to hear from you – how has tryptophan and GABA helped you or a loved one?
If you’d like to get on the notification list for the next Serotonin Quickstart Program (a paid online/virtual group program where you get my guidance and community support during 5 LIVE Q&A calls), please do so here.
If you’re a practitioner do you use tryptophan and GABA with your clients/patients?
Feel free to share and ask your questions below.