ruminating thoughts

The correlation between terrible anxiety/panic attacks and collagen

July 25, 2025 By Trudy Scott 14 Comments

Bea shared her collagen experience and insights on one of the collagen blogs:

I discovered the correlation between terrible anxiety and collagen myself several years ago! Couldn’t find any data about it then so just assumed I was a weirdo. But then my 26 yr old daughter started having terrible panic attacks. And bam! She too had started a collagen supplement! So I realized at least 2 ladies have this trouble! Got me to think about how many women seek anti-aging help with collagen and then also end up on prescriptions to help calm terrible anxiety without seeing the connection. Practitioners don’t seem to know about this. But every vitamin shop I visit hears from me on the anxiety/collagen connection. Perhaps grassroots word of mouth will help others eventually.

And yesssss… for me, bone broth is equally horrible!! Even if it is simmered for only 30 mins.

Thank you for explaining, Trudy!! How fascinating to learn it’s the drop in serotonin! I’ve never tried Tryptophan… just a bit nervous. But I think it’s time. I sure need the bone broth for my waning gut health. And I’m weary of ruminating thoughts lately! Thank you immensely for shining a needed light on how these amino acids help! I only wish I could share lunch with you and pass along my grateful hug!

God bless you, Trudy!

I’m so glad Dea found this correlation for herself and her daughter! Collagen use is on the rise and there is little awareness about these effects on serotonin levels in susceptible individuals. Read on for many of the anti-aging benefits of collagen, more information about tryptophan depletion studies, another similar story, other possible causes, and other blog resources on this topic.

Collagen use as we age: for skin, joints and bone health

Her comment about an increase in collagen use for anti-aging is so true. This 2023 paper, Collagen supplementation in skin and orthopedic diseases: A review of the literature, discusses the many age-related benefits of collagen:

hydrolyzed collagen supplementation promotes skin changes, such as decreased wrinkle formation; increased skin elasticity; increased hydration; increased collagen content, density, and synthesis, which are factors closely associated with aging-related skin damage.

Regarding orthopedic changes, collagen supplementation increases bone strength, density, and mass; improves joint stiffness/mobility, and functionality; and reduces pain. These aspects are associated with bone loss due to aging and damage caused by strenuous physical activity.

This paper mentions these aspects about collagen, that it’s low in tryptophan and that it is not a complete protein i.e. it’s a low biological value protein:

Notably, collagen is a low-tryptophan protein, an essential amino acid for humans.
Collagen is a source of conditionally essential amino acids (glycine and proline), which are important in some physiological situations.
Collagen is a low biological value protein, since its amino acid composition is poor in essential amino acids. However, it has a positive intrinsic value because its amino acid composition is equivalent to that of human connective tissue.

This supports what we have learned from acute tryptophan depletion studies causing low serotonin.

Tryptophan-depletion studies to study the relationship between low serotonin and depression

Here is my first blog explaining acute tryptophan depletion studies (published in 2017) – Collagen and gelatin lower serotonin: does this increase your anxiety and depression?.

Tryptophan-depletion studies have been done for years, as a way to study the relationship between low serotonin and depression. Often a tryptophan-deficient amino acid mixture is used for this purpose. More recently, collagen and gelatin are being used.

Collagen and gelatin are an excellent source of these amino acids: proline, glycine, glutamine and arginine, but they do not contain the amino acid tryptophan.

This paper, Pharmacokinetics of acute tryptophan depletion using a gelatin-based protein in male and female Wistar rats summarizes what we find in a number of studies that use gelatin for the purpose of lowering serotonin levels, in order to study the relationship between serotonin and behavior:

The essential amino acid tryptophan is the precursor of the neurotransmitter serotonin. By depleting the body of tryptophan, brain tryptophan and serotonin levels are temporarily reduced. In this paper, several experiments are described in which dose and treatment effects of acute tryptophan depletion (ATD) using a gelatin-based protein-carbohydrate mixture were studied in male and female Wistar rats.

I encourage you to read the above blog to learn about who may be more susceptible to these effects.

I also share my personal experience with collagen consumption and can totally relate to Bea’s story and what clients and those in my community have shared.

Toni used collagen for 8 months – anxiety and panic attacks are off the charts

Toni experienced something similar:

I’ve been using Organic collagen for about 8 months now… love the hair and skin results. My tummy felt better at first but not currently. My anxiety and panic attacks are off the charts: panic attacks, heart racing, sweating, brain fog. I want to escape – like fight or flight. Definitely obsessing and fears. Memory difficulty. I have an upcoming GI appointment to check for Candida /SIBO… but I had no idea this could add to my anxiety. I’ll be looking forward to more information, Seriously.

And a few weeks after stopping the collagen she shared this:

I stopped using collagen. Since then, my anxiety and panic have decreased by less than half. Mild in comparison. I’m definitely taking a long break.

Instead of stopping collagen altogether, my advice is to figure out if low serotonin is the cause and address this with tryptophan or 5-HTP so collagen can be used for its many anti-aging and health benefits.

Is their anxiety due to reduced serotonin or histamine, glutamate or oxalate issues

Keep in mind tryptophan will help and allow collagen, gelatin and broth to be consumed without the increase in anxiety and panic attacks (and sleep issues) only if it is due to low serotonin.

Presumably both Dea and her daughter have other low serotonin symptoms – in addition to anxiety and panic attacks – such as sleep issues, worry, fears, afternoon/evening cravings etc (here is the list of symptoms). As you can see from Toni’s feedback (above), she does have many low serotonin symptoms.

A trial of tryptophan and symptom reduction (initially until the ideal dose is found) will confirm symptoms are related to low serotonin very quickly. This will also help Dea with her nervousness and ruminating thoughts, help her daughter ease the feelings of panic and help Toni too.

It’s also often helpful to also rule out histamine, glutamate and oxalate issues from collagen, gelatin and broth intake – as all of these factors can contribute to an increase in anxiousness too.

Additional blog posts on the topic of collagen

In case you are new to these potential issues, here are additional blog posts on the topic:

If you are new to this topic and are still skeptical about all this, do read the many comments and stories on these blogs. It’s a way more common issue than you’d think!

Additional resources when you are new to using tryptophan and other amino acids as supplements

As always, I use the symptoms questionnaire to figure out if low serotonin or other neurotransmitter imbalances may be an issue.

If you suspect low levels of any of the neurotransmitters and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids on your own so you are knowledgeable. And be sure to share it with the practitioner/health team you or your loved one is working with.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control (this is covered in an entire chapter too), sugar cravings, anxiety and mood issues.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the amino acids that I use with my individual clients and those in my group programs.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms). This is a paid online/virtual group program where you get my guidance and community support. You can sign up to be notified when the next live launch is happening.

If you need serotonin support, the Serotonin QuickStart Program is a good place to get help. This is also a paid online/virtual group program where you get my guidance on using tryptophan and 5-HTP safely, and community support during 5 LIVE Q&A calls. You can sign up to be notified when the next live launch of this program is happening.

If you are a practitioner, join us in The Balancing Neurotransmitters: the Fundamentals program. This is also a paid online/virtual program with an opportunity to interact with me and other practitioners who are also using the amino acids.

Wrapping up and your feedback

I appreciate Dea for sharing her story on the blog and for sharing this information at vitamin stores – we do need more awareness, hence this new blog on the topic to further help create awareness.

It’s very likely that this is one big contributing factor to the rise in anxiety and sleep issues in perimenopause and menopause. And this is probably made worse because so many practitioners are still not aware.

I thanked her for her kind words, and said I’ll take a virtual lunch and a virtual hug from her.

Have you experienced any adverse effects from collagen, gelatin or bone broth?

Have you been able to continue using them by adding tryptophan?

And why do you use collagen/how is it helping?

If you’re a practitioner are you aware of this issue for certain susceptible individuals?

Feel free to share and ask your questions below.

Mom switches her teen son from 5-HTP to tryptophan. In 3 days he has less anxiety, fears and ruminating thoughts, laughs more and sleeps better.

February 16, 2024 By Trudy Scott 40 Comments

My son has autism and OCD. I took him off fluvoxamine in May and used cbd and some other things and he was doing fine up until this past winter. He began having irrational fears and ruminating thoughts/fears that would not stop! I started 5-HTP, theanine, B12, probiotics with him for the last month and did not see any improvement. I was ready to go back to the medication when I came across your blog and information.

I assumed 5-HTP would be better for OCD, but after reading your comments you mentioned that you just switch to tryptophan if the 5-HTP is not working. I had tryptophan at home already. That night I emptied half a capsule into a little stevia flavored water and had him hold it in his mouth for a minute.

He was a different kid after that!!!! This is just the 3rd day but even his teachers are telling me he is doing really well and is less anxious at school. I am so thankful! I am now giving him 500mg in the morning and early evening.

I bought some inositol and plan to try adding that in the afternoons to see if that will help as well. I believe that he has PANDAS. He is a hand washer, and spits a lot, and has lots of other quirks that I would love to see decrease.

I have hope again! I am buying your book so that I can get a good plan going for him. If you have any other suggestions for him please let me know!!

This wonderful feedback was posted in the comments of one of the tryptophan blogs. I’m so thrilled for this mom and young man (he’s almost 20). I thanked her for sharing all this on the blog and offered to share additional generic feedback via a new blog post. I also asked for additional feedback on exactly how the tryptophan helped (more on that below).

Read on to learn how tryptophan helped with his ruminating thoughts, fears, crying and improved his sleep. And my insights about the ideal timing of tryptophan, finding the optimal dose and why it may work when 5-HTP doesn’t. I also share some insights about inositol and OCD (obsessive compulsive disorder).

Low serotonin symptoms and the questions I had about his symptoms

I do hope he continues to see these benefits. Seeing such amazing results in 3 days is always what we’re looking for and it’s not unexpected to get such profound results so quickly!

I had some additional questions so I could share some general feedback as to how I work in situations like this. I wanted to know his age and if the switch to tryptophan helped any of his OCD symptoms and if yes how many notches improvement?

And which of the classic low serotonin symptoms the tryptophan helped and by how much: anxiety? irrational fears? and ruminating thoughts/fears? anything else? (all the low serotonin symptoms here)

Knowing this helps me know if I’m on track with a client i.e. the tryptophan is helping with low serotonin symptoms. And it also helps me decide we should consider increasing the dose and possibly adjust the number of times to use tryptophan. I share more about this below.

Tryptophan helps reduce his ruminating thoughts, fear and anxiety. And he’s laughing more and sleeps better

She shared some specific examples as to how much the tryptophan helps reduce his ruminating thoughts, fear and anxiety. And he’s laughing more and it helps him sleep:

He would often call me or text me throughout the day with questions about his health, and he would come to me 10-15 times in the afternoons/evenings, for about 3 weeks or so, and ask me the same questions about a rare disease that he believed he had.

He would cry and shake with fear and anxiety at some point and I would need to reassure him over and over again that he did not have this disease, and that it was literally impossible for him to have it.

After starting the tryptophan supplements 2x500mg morning/early evening he did not come to me at all and seemed content the 1st day.

Yesterday, he didn’t get the 2nd tryptophan until 5pm so he did come to me with 1 question/concern. I reassured him and he seemed fine especially after his supplement. Then 1 more question later that night but he accepted my reassurance both times and let it go.

So that was a big difference compared to the last 4 weeks. He was also laughing at some cartoon he was watching which I had not seen him do for a month either. Anxiety is less. He is sleeping better too. So far he still seems to believe the irrational things.

Tryptophan is clearly helping so many of his symptoms but we have more opportunities for further gains with tryptophan.

Tryptophan for low serotonin: dosing and timing

As I share in my book and other blog posts, typically 500 mg tryptophan twice a day is a good starting dose, used away from protein mid-afternoon and evening. It’s used like this because serotonin starts to decline in the afternoon. We increase based on individual needs to find the ideal dose. We may also add tryptophan or 5-HTP earlier in the day.

In a situation like this, if we were working together, I’d consider the following:

Adding a mid-afternoon dose of tryptophan
A switch to just afternoon and evening dosing (unless the morning dose was used for a specific reason i.e. morning symptoms)
Adding a second dose of tryptophan each time (he is using Nature Stacks Serotonin Brain Food and I’d recommend Lidtke 500 mg tryptophan for the second dose each time because it contains only tryptophan)

With changes we do one thing at a time and track symptom improvements carefully.

Tryptophan vs 5-HTP?

I commend her for figuring out the switch from 5-HTP to tryptophan.

It’s a well known fact that some folks just do better on one vs the other and if 5-HTP isn’t working I’ll have clients switch to tryptophan and vice versa. I typically start with tryptophan because it seems to be better tolerated. The biggest issue that I see with 5-HTP is that it’s often not tolerated if you have high cortisol. It can also cause nightmares for some folks.

Precaution about serotonin syndrome with tryptophan/5-HTP

There are precautions when using certain amino acids and I always review them with all my clients. If they have been prescribed an SSRI, I have them discuss the use of tryptophan/5-HTP with their prescribing doctor so they can be monitored for serotonin syndrome. With careful monitoring and doctor approval I feel comfortable having my clients use tryptophan/5-HTP 6 hours away from their one and only SSRI.

If they are using more than one SSRI and/or a combination of psychiatric medications, the use of tryptophan/5-HTP is not advised.

None of the above applied in this situation but it’s important to be aware of.

Inositol and OCD: when to consider adding it?

OCD or even mildly obsessive behaviors or thoughts can be a sign of low serotonin. I will do a trial of tryptophan as above and for some folks it’s often enough. Sometimes tryptophan at least helps to some degree and when it’s not enough, adding inositol (a B vitamin) takes it to the next level.

For many folks 500 -1000 mg capsules are typically recommended but this is a really low dose for OCD. The powdered form is really effective because you can increase as needed. You can actually go as high as 18g. I start low, with 1-2g in kids and adults, and keep going up by 2g a week until the obsessive symptoms disappear. More on inositol and OCD here.

GABA, dopamine and endorphin support too

She mentions that her son “seems to be low serotonin, low GABA (1st 1/2 of the list), low endorphins and low catecholamines” so other amino acids are likely to be of benefit too.

As always we used the neurotransmitter symptoms questionnaire and do trials of each amino acid: GABA for low GABA symptoms, DPA for low endorphins and tyrosine for low dopamine. These trials of each one are done one at a time with careful tracking to find the ideal dose before layering in the next amino acid.

Using the amino acids so it’s easy to reduce sugar and go gluten-free

I also asked what dietary changes he has already made and she responded: “We are in the process of reducing sugar and going back to gluten-free as much as possible but this will be hardest to stick to. Have done a keto-like and gluten-free-casein-free diet on and off since he was 4 years old.”

This is a great start and using the amino acids help reduce cravings and make it easy to reduce sugar and go gluten-free.

There is a sugar cravings aspect to all the neurotransmitter imbalances. The type of craving can be found on the above symptoms questionnaire. It’s not uncommon to need support in more than one area:

Low serotonin – tryptophan or 5-HTP for afternoon/evening cravings
Low endorphins – DPA for comfort/reward eating
Low catecholamines – tyrosine for low energy sugar cravings
Low GABA – GABA for stress eating

I’m glad she is getting a copy of my book The Antianxiety Food Solution. It has all the foundational dietary information, sections on cravings and a chapter on the amino acids.

It also has a chapter on pyroluria, which is very common in autism and something I help most of my clients address. Here is the pyroluria questionnaire.

Tryptophan and inositol product options

Products I recommend include Lidtke 500 mg Tryptophan and Designs for Health Inositol Powder. You can purchase these from my online store (Fullscript – only available to US customers – use this link to set up an account).

If you’re not in the US, Doctor’s Best L-Tryptophan 500mg and Now Inositol Powder are products I recommend on iherb (use this link to save 5%).

Additional resources when you are new to using tryptophan and other amino acids as supplements

We use the symptoms questionnaire to figure out if low serotonin or other neurotransmitter imbalances may be an issue for you.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), if you need serotonin support, the Serotonin QuickStart Program is a good place to start. This is a paid online/virtual group program where you get my guidance on using tryptophan and 5-HTP safely, and community support during 5 LIVE Q&A calls. You can sign up to be notified when the next live launch of this program is happening. We take a deep dive into product options including Lidtke products and others if you’re not able to access Lidtke.

If you also have low GABA symptoms, the next step to get help is the GABA QuickStart Program. This is also a paid online/virtual group program where you get my guidance and community support. Another option is the budget-friendly GABA QuickStart Homestudy program.

Now I’d like to hear from you

Have you had success with tryptophan for anxiety, fears, crying and ruminations? And has it also helped with sleep, how happy you feel and reduced cravings? Has it also helped with OCD?

Did you first trial 5-HTP and then found tryptophan worked better or vice versa?

If yes, what dose and when do you use it?

What about using inositol to further reduce OCD? And what dose helped?

If you’re a practitioner do you use tryptophan and/or inositol with clients/patients with these low serotonin symptoms?

And please let me know if it’s helpful that I’m now including product recommendations and where to get them?

Feel free to share and ask your questions below.

Tryptophan 3x/day: OCD and ruminating thoughts are no longer ruling my grandson’s life and he has the most beautiful serene smile

December 15, 2023 By Trudy Scott 34 Comments

I recently received this wonderful feedback from a grandmother who is so happy about tryptophan helping her 17-year old grandson. He had been struggling with OCD (obsessive compulsive disorder) and ruminating thoughts for years:

We started with Lidtke L-Tryptophan Chewables. I was thrilled beyond my greatest hopes to see that it helped immediately! So, we went forward with having him chew a tryptophan when the thoughts started taking hold. This helped for a while, but the thoughts would return.

Finally I read one mother on your blog who gave her son tryptophan 3x/day. So we tried this. That was the magic bullet for my grandson. Getting the tryptophan in before the thoughts could take hold made the difference. And so we have stuck with this plan and have been so happy to see that OCD is no longer ruling my grandson’s life.

Last week I heard the most beautiful words I could imagine. “Hey grandma! The OCD is permanently gone!” Truly a miracle! That’s how it feels to him. As long as we continue to take the tryptophan 3x/day, there is no sign of OCD or ruminating thoughts!

We keep GABA Calm on hand as well and if a bothersome thought enters his mind, he chews a GABA and we don’t hear any more about it.

I honestly don’t even know how to tell you what a blessing your information has been to my grandson. He has the most beautiful, serene smile almost all the time now.

In all my reading and searching for all these years, you’re the only one I saw talking about this. Thank you, from the bottom of my heart, for guiding us to giving this kid his life back. I pray that all the good things you have done to help people come back to you tenfold, Trudy. You are a Godsend.

How much tryptophan helped him and why using it 3 x a day was key

The amino acid tryptophan, used as a supplement, supports low serotonin levels which can cause the worry type of anxiety, ruminating thoughts and OCD (behaviors and thoughts). You can see all the low serotonin symptoms here.

Each of the Lidtke L-Tryptophan Chewables provides 100 mg tryptophan which is often a great starting dose for children and teens. Because it’s chewable and tastes sweet it’s also a great format for children and teens (and “pixie dust” adults who need a very small amount). The bad aspect is that it does contain sugar and is quite sweet. Because you are continually consuming something sweet you may end up over-consuming them if sugar addiction is your issue.

As you can see 100 mg tryptophan did provide some relief in the moment but using the amino acids consistently throughout the day is what I always recommend for best results. In this instance 100 mg tryptophan 3x day worked perfectly for this young man.

Keep in mind there is no one-size fits all for dosing and 100 mg tryptophan x3 per day is considered quite low with many individuals needing 500-1000 mg tryptophan two or three times a day. Also some individuals do better on 5-HTP so this should always be considered too (10 mg 5-HTP is equivalent to 100 mg tryptophan).

Precaution about serotonin syndrome with tryptophan/5-HTP

If they are using more than one SSRI and/or a combination of psychiatric medications, the use of tryptophan/5-HTP is not advised.

None of the above applied in this situation but it’s important to be aware of.

How GABA also helps and my recommendation about consistent use too

The amino acid GABA, used as a supplement, supports low GABA levels which can cause physical anxiety and tension, and also an inability to stop intrusive thoughts. You can see all the low GABA symptoms here.

Each GABA Calm provides 125 mg GABA and he uses it as needed: “We keep GABA Calm on hand as well and if a bothersome thought enters his mind, he chews a GABA.”

My recommendation is to assess for low GABA symptoms and consider using GABA consistently throughout the day, typically 2-4 x day.

OCD research: glutamatergic and serotonergic pathway dysregulation

This 2011 paper, Nutraceuticals in the treatment of obsessive compulsive disorder (OCD): a review of mechanistic and clinical evidence, states the following:

Current preclinical research investigating nutraceuticals (natural products) for OCD, reveals encouraging novel activity in modulating key pathways suggested to be involved in the pathogenesis of OCD (glutamatergic and serotonergic pathway dysregulation).

With glutamatergic pathway dysregulation, we would expect GABA to help; and with serotonergic pathway dysregulation, we would expect tryptophan (or 5-HTP to help), as this young man found.

However there are no studies that have used tryptophan for OCD and the above paper concludes that “the serotonin precursor tryptophan is unlikely to be of use in treating OCD while 5-HTP may possibly be a more effective precursor strategy.” The authors state this about 5-HTP because it has been used with success for OCD in conjunction with medication (read the study here).

This lack of research on tryptophan for OCD is one of the reasons I feel compelled to share wonderful success stories like this. And until we have tryptophan research, we must use what we see works clinically and recognize that tryptophan and 5-HTP work in very similar ways.

Other nutrients when tryptophan or 5-HTP or GABA doesn’t help

The above paper does mention other nutrients that are tentatively supported by research and which modulate these pathways: N-acetylcysteine (NAC), myo-inositol, glycine, and milk thistle.

These nutrients could be considered when tryptophan or 5-HTP or GABA doesn’t help or doesn’t help enough. I’ve had much success with myo-inositol for OCD and have always used it in conjunction with tryptophan or 5-HTP. We start with tryptophan or 5-HTP and find a good base line and then add inositol, starting with 500 mg and working up to 18 g/day (as reported in the research).

As you can see, in one study, NAC was shown to be helpful for trichotillomania, a behavioral disorder characterized by the recurring or obsessive habit of pulling one’s hair, resulting in secondary alopecia. I blogged about this here.

They tried many approaches and it took 3 years before they used the amino acids

Patricia, the grandmother, also shared what other approaches they had tried from the age of 14-17 years before seeing success with tryptophan and GABA: therapy, tapping, breathing techniques, acupuncture, yoga and tai chi. None of this helped enough and they rejected pharmaceutical approaches.

It breaks my heart that it took 3 years for her grandson to find relief:

I have been reading your information on OCD for several years (in all my reading and searching for all these years, you’re the only one I saw talking about this) and though I thought it was the best hope I’d heard of for stopping OCD and ruminating thoughts, I was afraid to try the amino acids because I knew so little about them.

So I studied and studied and gained confidence by reading the published reports that seemed to back up what you said about amino acids.

Still, since I was hoping to help my grandson, who was 14 at the time, I was overly cautious. I’m not a medical professional and I’m aware that even really safe and effective treatments can change more than just the issue I was hoping to address.

So, more reading and searching ensued. Meanwhile my grandson’s life was deteriorating. He couldn’t function in many ways because he had no peace. Even sleep was difficult because the thoughts wouldn’t rest – the poor kid had no time at all when his mind wasn’t racing. It broke my heart to see him suffer so much.

Finally, I got the strength to trust my gut and try the amino acids.

I admire Patricia for reading, searching and studying and finally being well-informed enough to help her grandson. And then sharing his story with me so I can share it here with you. She was inspired by one of my other blogs and hopefully you will be inspired and motivated by this wonderful success story.

My hope, with stories like this, is that the amino acids and nutritional approaches are considered first and not after all else has failed.

Additional resources when you are new to using tryptophan, 5-HTP, GABA and the other amino acids as supplements

We use the symptoms questionnaire to figure out if low serotonin or low GABA may be an issue for you.

There is an entire chapter on the amino acids and they are discussed throughout the book in the sections on gut health, gluten, blood sugar control, sugar cravings, anxiety and mood issues.

If, after reading this blog and my book, you don’t feel comfortable figuring things out on your own (i.e. doing the symptoms questionnaire and respective amino acids trials), a good place to get help is the GABA QuickStart Program (if you have low GABA symptoms too). This is a paid online/virtual group program where you get my guidance and community support.

Have you had success using tryptophan (or 5-HTP) and GABA this way for your OCD and ruminating thoughts or for a loved one? If yes, how much helps?

If you’re a practitioner do you have success using tryptophan (or 5-HTP) and GABA this way with your clients/patients who have OCD and ruminating thoughts?

Feel free to share and ask your questions below.

GABA helps with inhibition of unwanted thoughts

November 17, 2017 By Trudy Scott 74 Comments

There is plenty of research and clinical evidence showing that low serotonin promotes worry and ruminating thoughts and we know that using tryptophan (or 5-HTP) can help with easing these worries and unwanted thoughts i.e. the worry-in-the-head type of anxiety.

The calming supplement GABA has long been recognized to help ease the more physical type of anxiety where you feel body tension and may have stiff and tense muscles.

Over the last year I’ve been getting feedback from women in my community saying that oral GABA supplements also helps some of the head symptoms too and now we have some new research supporting the possible mechanism of this – Scientists identify mechanism that helps us inhibit unwanted thoughts:

We are sometimes confronted with reminders of unwanted thoughts – thoughts about unpleasant memories, images or worries. When this happens, the thought may be retrieved, making us think about it again even though we prefer not to. While being reminded in this way may not be a problem when our thoughts are positive, if the topic was unpleasant or traumatic, our thoughts may be very negative, worrying or ruminating about what happened, taking us back to the event.

Scientists have identified a key chemical within the ‘memory’ region of the brain that allows us to suppress unwanted thoughts, helping explain why people who suffer from disorders such as anxiety, post-traumatic stress disorder (PTSD), depression, and schizophrenia often experience persistent intrusive thoughts when these circuits go awry.

Professor Anderson, Dr. Schmitz and colleagues showed that the ability to inhibit unwanted thoughts relies on a neurotransmitter – a chemical within the brain that allows messages to pass between nerve cells – known as GABA.

GABA is the main ‘inhibitory’ neurotransmitter in the brain, and its release by one nerve cell can suppress activity in other cells to which it is connected.

Anderson and colleagues discovered that GABA concentrations within the hippocampus – a key area of the brain involved in memory – predict people’s ability to block the retrieval process and prevent thoughts and memories from returning.

The study is looking at GABA concentrations within the hippocampus and there is no mention of the use of GABA supplementation to enhance this process:

While the study does not examine any immediate treatments, Professor Anderson believes it could offer a new approach to tackling intrusive thoughts in these disorders.

Ideally the next step will be to study the use of oral GABA supplementation.

Here is the study abstract: Hippocampal GABA enables inhibitory control over unwanted thoughts

UPDATE Jan 28, 2022:

This 2021 paper, Astroglia and Obsessive Compulsive Disorder, supports the low GABA mechanism when it comes to obsessive compulsive disorder/OCD which is characterized by persistent intrusive thoughts (obsessions) and repetitive behaviors (compulsions).

The researcher shares the most prominent theory regarding the underlying mechanisms of OCD and persistent intrusive thoughts (and compulsions):

an increased excitation to inhibition (E/I) ratio due to increased glutamatergic excitation or reduced GABAergic inhibition.

And states that, in astrocytes (a subtype of glial cells), both the glutamate transporter GLT1 and GABA transporter GAT-3 are critical for regulating this balance.

Feedback on GABA helping with overactive brain and perseveration

When I shared this research on facebook two people commented on how the Source Naturals GABA Calm product I recommend helps them with this aspect of anxiety.

Tiffany shares how Source Naturals GABA Calm helps calm her overactive brain:

I have definitely noticed that sublingual GABA Calm that you suggest helps calm my overactive brain.

Dawn shares how this same GABA product has helped her a lot:

I have an old TBI [traumatic brain injury] and the physiology of PTSD, from childhood trauma, so a double whammy. This sublingual lozenge makes a big difference in my day if I start to get anxious, or begin to perseverate on something that really isn’t all that important.

Perseverate is not a word I use very much and in case you’re not familiar with this term, the Oxford dictionary defines it as follows: “repeat or prolong an action, thought, or utterance after the stimulus that prompted it has ceased.” It’s also defined as: “the tendency of an idea to stick in your mind or recur, or getting stuck on something mentally and not being able to shift gears.” In psychiatry it’s “the persistent and pathological repetition of a verbal or motor response, often seen in organic brain disease and schizophrenia.”

Updating the GABA questionnaire and GABA blog

I’m using this research and feedback to make an update of the low GABA section on the amino acid questionnaire:

Do you have intrusive thoughts, perseverate or have an overactive brain? Or do you have unwanted thoughts – thoughts about unpleasant memories, images or worries?

I’ve also updated this recent blog post – Anxiety, compulsive thinking, counting behaviors: gluten, tryptophan and inositol where I to share my feedback on a question I received on how to approach working with a child with anxiety, compulsive thinking and counting behaviors. I mentioned GABA as a possibility but with her symptoms and this new research, a GABA trial would definitely be something to pursue.

Resources if you are new to using GABA as a supplement

If you are new to using the the amino acid GABA as a supplement, here is the Amino Acids Mood Questionnaire from The Antianxiety Food Solution (you can see the low GABA and other low neurotransmitter symptoms) and a brief overview here: Anxiety and targeted individual amino acid supplements: a summary.

If you suspect low levels of GABA and do not yet have my book, The Antianxiety Food Solution – How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood, and End Cravings, I highly recommend getting it and reading it before jumping in and using amino acids so you are knowledgeable. And be sure to share it with the team you or your loved one is working with.

The book doesn’t include product names (per the publisher’s request) so this blog, The Antianxiety Food Solution Amino Acid and Pyroluria Supplements, lists the GABA products that I use with my individual clients and those in my group programs.

I’d love your feedback

Do you resonate with any of this and have you seen this benefit when using GABA, in addition to the relief of physical anxiety?
If you’ve also observed improvements in your ruminating thoughts when using tryptophan, I’d love you to try and share how GABA helps and how tryptophan helps i.e. how you feel before and after with each supplement?
Also, if you are also using tryptophan and/or 5-HTP how do you know if it’s these amino acids or the GABA that is helping?
I’m really looking for the differences you observe as you support low GABA vs low serotonin? Are they clear or are they blurred?
If you’re a practitioner what feedback do you get from your clients/patients about low GABA vs low serotonin?

As I mention above I would love to see follow-on research showing that sublingual GABA supplements can actually shift this. Sharing what we see clinically will be very helpful so your feedback is valuable and appreciated.

Feel free to ask your questions here too.