grainflammation

 

Dr. Peter Osborne DC, author of Glutenology, was interviewed on the Anxiety Summit by host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution.

Grainflammation – How Grain Consumption Contributes to Anxiety and other Mood Disorders

• Gluten and autoimmunity
• Schizophrenia and “bread madness”
• How gluten and all grain consumption can lead to chemical changes in the brain
• How the gluten in corn can impact the mind and mood
• Concerns with seeds and grains
• DNA testing for celiac and non-celiac gluten sensitivity

Here are some snippets from our interview:

Gluten is notorious for damaging the gastrointestinal tract.  I know iron, in the literature,  has always been reported as the most common most deficiency in gluten sensitivity. In my 15 years of practice, measuring both ferritin as well as iron panels and vitamin B₁₂ levels, I see B₁₂ being much, much more common as a deficiency in those with gluten sensitivity. The most common side effect of B₁₂ deficiency, beyond fatigue, is actually anxiety.

We discussed the work of Dr Alessio Fasano, world-renowned pediatric gastroenterologist, research scientist and entreprenuer,  chief of Pediatric Gastroenterology and Nutrition at MassGeneral Hospital for Children (MGHfC).

The second barrier is called the right junction, which we know gluten can cause a disruption in tight junctions. This was discovered by Alessio Fasano at Harvard. He actually discovered it while he was at University of Maryland Celiac Research Facility. He discovered these tight junctions were disrupted and dismantled as a result of gluten exposure.

We also know bacterial infections can disrupt these barriers. We also have some evidence that show that glyphosate in Roundup and other chemical artificial pesticides and herbicides can disrupt this gastrointestinal barrier.

We discussed lipopolysaccharides (LPS) and how they

can create a lot of inflammatory reaction, and they can contribute to a breakdown in the blood brain barrier

Here is a recent paper on LPS and anxiety and depression: Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood

We found that mice exposed to LPS show anxiety- and depression-related behaviors

In addition, LPS mice had reduced serotonin and noradrenaline levels in the hippocampus

Here is the blood brain barrier paper discussed – The blood-brain barrier in neuroimmunology: Tales of separation and assimilation

The corn zein discussion was fascinating and concerning because so many people are eating gluten-free products that contain corn (another reason to pass on the processed gluten-free products and just eat real whole food!)

Here are two papers that discuss this (corn is called maize in South Africa)

• Maize prolamins resistant to peptic-tryptic digestion maintain immune-recognition by IgA from some celiac disease patients
• Maize prolamins could induce a gluten-like cellular immune response in some celiac disease patients.

Here is Dr. Osborne’s gift: 7 Habits of the Highly Effective Gluten-Free Warrior (3 videos)

Here is the information about Genetic Testing For Gluten Sensitivity and Celiac Disease

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