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Mitomics – genetics of the mitochondria and food based antioxidants like curcumin

By Trudy Scott 2 Comments

Dr. David Haase, a functional medicine doctor and a leader in the field of genetics and genomics, covers mitomics in this very interesting interview on the upcoming Interpreting Your Genetics Summit which runs August 21-28, 2017.

Mitomics is the genetics of the mitochondria themselves. The mitochondria have their own set of genes. And that’s often given a lot of importance because we get our mitochondria from our mothers and therefore we inherit this genome from the mother and we get our mother’s energy per se.

But when you step back a little bit, you recognize that the genetics of the mitochondria are not just nuclear. It’s not just thirty-seven genes that hang out in the mitochondria, but rather, there is over a thousand genes that are in the nucleus that control the proteins or make proteins and influence the mitochondria at great levels. I’ve used a company called Courtagen who do whole mitome analysis. And in individuals with chronic fatigue syndrome or bizarre multi-system dysfunction, this is instrumental in giving a new plan of action to address.

He shares the story of a patient who had had chronic pain, fatigue and irritable bowel syndrome (a mitochondrial symptom)

She had tachycardia, palpitations, some dizziness. And so we actually did a whole mitome analysis on her and we found that she had a uniqueness in something called the TRAP1 related disease. I think it’s clever because the acronym is T1RED.

And this TRAP actually codes for a protein, which is a chaperone to the mitochondria and it’s involved in antioxidant defenses. And what’s been shown is that individuals with this TRAP1 related disease will be queasy, they’ll have pain and they’ll be fatigued and highly aggressive.

But when we found that she had this heterozygote for this particular abnormality – and it was associated with her having a lot of oxidative stress and elevation of hydroxyguanidine, which is a marker of genetic damage and oxidative damage, and elevations in her CK [creatine kinase], which was a marker of muscle injury. We went into this very intense antioxidant program with a lot of food-based antioxidants: sulforaphane, curcumin, resveratrol, CoQ10 and alpha-lipoic acid.

We went after this as aggressively as I think I’ve ever gone after this in a single patient with doses that are in excess of what I would typically use. And she had a remarkable recovery.

I share this snippet because with the tachycardia (an abnormally fast resting heart rate of at least 100 beats per minute) and palpitations, you may think it’s anxiety with a root cause such as low GABA or low serotonin or high cortisol or even Hashimoto’s thyroiditis, when in fact these symptoms are caused by mitochondrial TRAP-1 related disease.

I hope you can join us on Interpreting Your Genetics Summit, August 21-28, 2017. You can register here.

Here are some other reasons to attend:

  • once you register you’ll have immediate access to these interviews: Epigenetic Mastery for Everyone from Andrea Nakayama, CNC, CNE; The Current State of Genetics from Jeffrey Bland, PhD; and Your Genetics and Autoimmune Diseases with Dr. Tom O’Bryan, DC, CCN.
  • my digital ebook is available to you if you choose to purchase the series: Anxiety, Benzodiazepines and Your Genetics
  • as part of the lead up to the event, summit host, James Maskell will even be doing three of his own genetic tests and getting them interpreted by speakers from the summit

James Maskell has gathered world-renowned leaders from genetics, genomics and functional medicine and this promises to be a cutting-edge online event. These pioneering experts are on the front lines interpreting genetic data!

Hope to “see you” on the summit.

UPDATE August 11: I just went to the site and see this message today “Courtagen has closed its diagnostic laboratory and will no longer be accepting samples.”

They have a link to this press release of July 18 so it’s a brand new change: “Courtagen Life Sciences Inc. announced today that the company will be shifting the core focus of its business to medicinal cannabis genetics and testing. As the company reorients its business to respond to the growing opportunities in the medicinal cannabis industry, the company has made the decision to wind down its diagnostic neurology testing division.”

The Anxiety Summit – Eggs, broths, sprouts, almond flour, questions and what to do next

By Trudy Scott 31 Comments

Trudy Scott Anxiety

The host of the Anxiety Summit, Trudy Scott, Food Mood Expert and Nutritionist, author of The Antianxiety Food Solution talks about:

Eggs, broths, sprouts, almond flour, questions and what to do next

  • Are eggs a superfood? and choline for a better mood and less anxiety
  • More superfoods: broths, sprouts and curcumin
  • Reconsidering almond flour for baking
  • Questions answered (a select few from the blog and facebook page)
  • What you can get out of the summit, resources and where to go next

We’ve gathered all the speaker/topic blogs into one blog called Anxiety Summit Season 2 speakers and topics so you can find them easily. These have snippets from our interviews, links to research, and links to speaker books and gifts.  You can also use these blogs to comment, share your experiences and ask questions. 

Here is the New York Times article U.S.D.A. Approves Modified Potato

The potato’s DNA has been altered so that less of a chemical called acrylamide, which is suspected of causing cancer in people, is produced when the potato is fried.

A Huffpo blog announces Doritos-Flavored Mountain Dew Is Real

Here is New York City’s first take-out window devoted to sippable broths

I recently spoke on Dr. Josh Axe’s Natural Cures summit and here is a great broth recipe on his site

I love this picture in the LA urban farming article

The dinner menu lists “our home-grown items”: broccolini, baby carrots, blueberries, figs, snap peas and heirloom tomatoes.

Here is a link to Julia Rucklidge’s TEDX talk: The surprisingly dramatic role of nutrition in mental health. I love how she opens with:

what I’m going to share today may sound as radical as hand-washing sounded to a mid-19th century doctor and yet it is equally scientific. It is the simple idea that optimizing nutrition is a safe and viable way to avoid, treat or lessen mental illness. Nutrition matters. Poor nutrition is a significant and modifiable risk factor for the development of mental illness

Eggs are one of the most nutritious foods on earth! Here is some of the egg research:

“Orally administered whole egg demonstrates antidepressant-like effects in the forced swimming test on rats”

Skipping breakfast can increase depression, anxiety and stress levels and eggs can be part of a healthy breakfast. “A cross-sectional investigation of depressive, anxiety, and stress symptoms and health-behavior participation in Australian university students”

Eggs are an excellent source of choline. Research shows that plasma choline levels are related to anxiety levels

The lowest choline quintile was significantly associated with high anxiety levels.

Results from an October 2014 study in Behavioral Brain Research suggest that

high choline intake during early development can prevent or dramatically reduce deficits in social behavior and anxiety in an autistic mouse model

An article on Webmd, Egg-Rich Diet Not Harmful in Type 2 Diabetes suggest that

eating two eggs per day, 6 days a week can be a safe part of a healthy diet for people with type 2 (that’s 12 eggs a week – yeah!)

I blogged about eggs and that you can eat the yolk this last month. You can read about TMAO concerns in the comments of the above blog.

Grow your own broccoli sprouts to get sulforaphane! Here is the study called Sulforaphane treatment of autism spectrum disorder (ASD), published Oct 2014

improvement in social interaction, abnormal behavior, and verbal communication

… oxidative stress, depressed glutathione synthesis, reduced mitochondrial function and oxidative phosphorylation, increased lipid peroxidation, and neuroinflammmation

Here is the curcumin depression study

In a randomised, double-blind, placebo-controlled study, 56 individuals with major depressive disorder were treated with curcumin (500 mg twice daily) or placebo for 8 weeks.

From weeks 4 to 8, curcumin was significantly more effective than placebo in improving several mood-related symptoms

Here is my healthy travel foods blog that includes pemmican, THE energy bar of the 21st century. You can purchase pemmican from US Wellness Meats.

Here is my carob blog with the yummy Carob Cinnamon Delight al la Trudy

I mentioned a number of studies related to PTSD symptoms. Here they are:

Here are the Amino Acid Precautions. They will also be added to my blog Targeted individual amino acids for eliminating anxiety: practical applications.

If you are wanting to find out more about pyroluria, do check out my session from season 1 “How zinc and vitamin B6 prevent pyroluria and social anxiety.   And here is the pyroluria questionnaire from my book.

If you missed my opening interview here are a few lines from “Top of the World”

A new beginning, a brand new day
All of my fears are gone away
I feel so calm, so free, so whole
Right now, I’m feeling on top of the world

Grab your copy of the song here if you don’t yet have it!

“Food and nutrients provide a very powerful approach that can dramatically reduce and very often completely eliminate anxiety- and can totally prevent it in the first place too.”

You can have zero anxiety! Really! You deserve to feel on top of the world.

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here www.theAnxietySummit.com