{"id":8677,"date":"2019-10-07T10:35:25","date_gmt":"2019-10-07T17:35:25","guid":{"rendered":"https:\/\/www.everywomanover29.com\/blog\/?p=8677"},"modified":"2024-05-02T16:39:13","modified_gmt":"2024-05-02T23:39:13","slug":"mthfr-b12-genes-and-anxiety-with-carolyn-ledowsky-on-the-anxiety-summit-5","status":"publish","type":"post","link":"https:\/\/www.everywomanover29.com\/blog\/mthfr-b12-genes-and-anxiety-with-carolyn-ledowsky-on-the-anxiety-summit-5\/","title":{"rendered":"MTHFR, B12 Genes and Anxiety with Carolyn Ledowsky on The Anxiety Summit 5"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-8678 size-full\" src=\"https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/mthfr-as5.png\" alt=\"MTHFR Anxiety Summit 5\" width=\"940\" height=\"492\" srcset=\"https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/mthfr-as5.png 940w, https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/mthfr-as5-300x157.png 300w, https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/mthfr-as5-768x402.png 768w, https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/mthfr-as5-610x319.png 610w\" sizes=\"(max-width: 940px) 100vw, 940px\" \/><\/p>\n<p>Carolyn Ledowsky, ND is one my guest experts on <a href=\"https:\/\/www.theanxietysummit.com\/as5\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>The Anxiety Summit 5: Gut-Brain Axis<\/strong><\/a> and our topic is: <strong>MTHFR, B12 Genes and Anxiety<\/strong>. In this interview you\u2019ll learn:<\/p>\n<ul>\n<li>The mechanisms of methylation<\/li>\n<li>B12 gene variants: MTR, MTRR, TCN<\/li>\n<li>The tryptophan \u201csteal\u201d and a simple niacin test<\/li>\n<li>and a whole lot more!<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.theanxietysummit.com\/as5\/\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"aligncenter wp-image-8681\" src=\"https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/carolyn-ledowsky-as5.png\" alt=\"carolyn ledowsky\" width=\"200\" height=\"275\" srcset=\"https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/carolyn-ledowsky-as5.png 363w, https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/carolyn-ledowsky-as5-218x300.png 218w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<p>It\u2019s an in-depth interview that really gets into the science and mechanisms, and we start with why methylation is so important:<\/p>\n<blockquote><p>We need methylation to create one of the most important brain substances &#8211; phosphatidyl choline &#8211; because our brain lives on it. This is incredibly important for neurotransmitter function.<\/p>\n<p>And unfortunately, this whole methylation process is not only affected by our genes but it\u2019s hugely affected by our environment. Stress is probably one of the one of the biggest things that chews up our methyl groups.<\/p><\/blockquote>\n<p>We also talk about what the research is showing and discuss a 2018 paper titled <strong>Methylenetetrahydrofolate reductase and psychiatric diseases<\/strong>:<\/p>\n<blockquote><p>Increasing evidence demonstrates that MTHFR polymorphism including C677T and A1298C is associated with psychiatric diseases. The MTHFR gene polymorphism is linked to onset, clinical symptoms, prevalence as well as response to treatments.<\/p><\/blockquote>\n<p>If you have a MTHFR polymorphism and it\u2019s expressing it\u2019s very likely contributing to neurotransmitter imbalances and playing a role in both anxiety and depression. Methylation is also important for detox and fertility, and often plays a role in ADHD, bipolar, schizophrenia and autism.<\/p>\n<p><a href=\"https:\/\/www.theanxietysummit.com\/as5\/\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-8682\" src=\"https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/carolyn-ledowsky-trudy-scott-as5.png\" alt=\"carolyn ledowsky and trudy scott\" width=\"800\" height=\"229\" srcset=\"https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/carolyn-ledowsky-trudy-scott-as5.png 800w, https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/carolyn-ledowsky-trudy-scott-as5-300x86.png 300w, https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/carolyn-ledowsky-trudy-scott-as5-768x220.png 768w, https:\/\/www.everywomanover29.com\/blog\/wp-content\/uploads\/2019\/10\/carolyn-ledowsky-trudy-scott-as5-610x175.png 610w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><\/p>\n<p>Carolyn covers SAMe, folate and the importance of addressing low B12 first and how this ties back to the gut, low HCl (hydrochloric acid) and nutrient absorption. We cover\u00a0 B12 genes (MTR, MTRR, TCN) in detail, B12 testing, ideal forms of B12 supplementation based on your SNPs and more.<\/p>\n<p>The connections she has found with pyroluria, oxalates, the CBS gene, glutathione, vitamin B6 and lysine is just fascinating and I look forward to really digging into the research and mechanisms in the future.\u00a0 This was not on our planned outline of topics to discuss but we went with it anyway and I\u2019m so glad we did.<\/p>\n<p>We end with a discussion on the tryptophan steal and niacin, and agree to differ on our use of tryptophan &#8211; she prefers 5-HTP while I typically start with tryptophan and then have my clients switch to a trial of 5-HTP if the tryptophan is not helping.<\/p>\n<p>Carolyn Ledowsky is the founder of MTHFR Support Australia. She is a naturopath, herbalist and nutritionist and based on what I learned in this interview and this lovely note of appreciation I received yesterday, I know you\u2019ll really enjoy it:<\/p>\n<blockquote><p>I had to write to you to to thank you for your work. I\u2019ve bought your book and followed you for a while, but that interview with Carolyn Ledowsky was probably one of the most eye opening talks I\u2019ve ever listened to! The way she explained all the difficulties with the MTHFR gene was a wealth of information, and you both worked together so well to really make things clear. I feel I have hope, and better understand what the problem is. Thank you again.<\/p><\/blockquote>\n<p>Getting feedback like this makes my day because we\u2019re sharing great information and offering hope!\u00a0 May this inspire you to tune in and learn too.<\/p>\n<p><span style=\"font-weight: 400;\">You can listen to the entire interview by purchasing <\/span><a href=\"https:\/\/www.theanxietysummit.com\/as5\/\" target=\"_blank\" rel=\"noopener\"><b>The Anxiety Summit 5: Gut-Brain Axis<\/b><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you\u2019d like to give feedback or ask a question, please post in the comments section. I\u2019d love to hear from you once you\u2019ve listened in.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Carolyn Ledowsky, ND is one my guest experts on The Anxiety Summit 5: Gut-Brain Axis and our topic is: MTHFR, B12 Genes and Anxiety. In this interview you\u2019ll learn: The mechanisms of methylation B12 gene variants: MTR, MTRR, TCN The tryptophan \u201csteal\u201d and a simple niacin test and a whole lot more! It\u2019s an in-depth [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":8678,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[1681],"tags":[46,282,1693,723,291],"class_list":["post-8677","post","type-post","status-publish","format-standard","has-post-thumbnail","category-anxiety-summit-5","tag-anxiety","tag-anxiety-summit","tag-b12-genes","tag-carolyn-ledowsky","tag-mthfr-2","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MTHFR, B12 Genes and Anxiety with Carolyn Ledowsky on The Anxiety Summit 5 - everywomanover29 blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.everywomanover29.com\/blog\/mthfr-b12-genes-and-anxiety-with-carolyn-ledowsky-on-the-anxiety-summit-5\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MTHFR, B12 Genes and Anxiety with Carolyn Ledowsky on The Anxiety Summit 5 - everywomanover29 blog\" \/>\n<meta property=\"og:description\" content=\"Carolyn Ledowsky, ND is one my guest experts on The Anxiety Summit 5: Gut-Brain Axis and our topic is: MTHFR, B12 Genes and Anxiety. In this interview you\u2019ll learn: The mechanisms of methylation B12 gene variants: MTR, MTRR, TCN The tryptophan \u201csteal\u201d and a simple niacin test and a whole lot more! 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