{"id":5396,"date":"2016-09-30T14:00:53","date_gmt":"2016-09-30T21:00:53","guid":{"rendered":"https:\/\/www.everywomanover29.com\/blog\/?p=5396"},"modified":"2025-10-31T05:51:01","modified_gmt":"2025-10-31T12:51:01","slug":"seriphos-reformulated-high-cortisol","status":"publish","type":"post","link":"https:\/\/www.everywomanover29.com\/blog\/seriphos-reformulated-high-cortisol\/","title":{"rendered":"Seriphos has been reformulated – what do I use to lower high cortisol?"},"content":{"rendered":"
\"seriphos\"
V1. The very old bottle (many years ago): Phospholylated Serine on the front<\/p>\n

V2. Old label, original formulation (2 years ago?): Phospholylated Serine on the front<\/p>\n

V3. New label, new formulation (5 months ago): Phosphatidylserine on the front<\/span><\/figcaption><\/figure>\n

Last month I wrote a blog called Tryptophan and melatonin make a big difference but why do I still wake at 4am?<\/a>\u00a0and included a section about high night-time cortisol (measured with an adrenal salivary test) also being a factor with insomnia and waking in the night, often with anxiety. I then shared my top product for lowing high cortisol, Interplexus Seriphos, and had a number of readers (very kindly) inform me that Seriphos has been reformulated. One person shared this:<\/p>\n

In your blog you recommend Interplexus Seriphos for those who have a high cortisol problem. What you may not know is that Interplexus changed its proprietary formula sometime March\/April 2016 to a form which no longer works for many of us.<\/p>\n

This is also true for me as I have been taking the new formula and the sleep issues have returned: waking at 2 am and not being able to go back to sleep. I have asked my functional medicine doctor and called Interplexus but they cannot help. Since you are an expert in such matters, PLEASE, help find another product like the old Seriphos (prior to March 2016) so that all of us who were happy with the old product can get back to the business of sleeping through the night.<\/p><\/blockquote>\n

Someone else shared this:<\/p>\n

I was using the phosphorylated serine found in Interplexus Seriphos from November 2015 until present. For the first 6 months it was like a miracle pill calming me and leaving me feel normal, not like Niagara Falls was rushing through my veins.<\/p>\n

Sometime in the spring 2016 I noticed the Seriphos was not working and read the reviews on Amazon that Interplexus had changed the formula.<\/p><\/blockquote>\n

I was not aware that the formulation had changed<\/h2>\n

I was not aware that the formulation had changed and love that I get to learn from my community too \u2013 thank you for letting me know!<\/p>\n

I had not seen any new clients since just before the Anxiety Summit in June and my existing clients who are using the original Seriphos have enough stock to not have noticed the change or brought it to my attention.<\/p>\n

It\u2019s such a pity it has been reformulated because it\u2019s been so powerful for lowering high cortisol and quickly when 1-3 x Seriphos (the original) are taken about 2-3 hours before the high cortisol. I first learned about this phosphorylated serine product when working with Julia Ross and continued to use it very successfully in my practice.<\/p>\n

As you can see from the feedback above it truly was a lifesaver for these two women and for so many individuals.<\/p>\n

I\u2019m going to share what I have discovered thus far<\/h2>\n

I like to share what I know works but so many of you are desperately seeking a solution right now. I promised to look into what has happened so I\u2019m going to share what I have discovered thus far.<\/p>\n

It\u2019s always helpful to learn from feedback from others (both positive and negative) so I read through Steve Gibson\u2019s negative review on Amazon<\/a>\u00a0and found the very long thread of comments under this.<\/p>\n

I also reached out to my colleagues to ask what they are now using:<\/p>\n