{"id":10813,"date":"2023-01-13T14:00:59","date_gmt":"2023-01-13T22:00:59","guid":{"rendered":"https:\/\/www.everywomanover29.com\/blog\/?p=10813"},"modified":"2023-01-13T08:24:05","modified_gmt":"2023-01-13T16:24:05","slug":"transgenerational-transmission-of-aspartame-induced-anxiety-and-changes-in-glutamate-gaba-signaling-a-new-study-and-solutions","status":"publish","type":"post","link":"https:\/\/www.everywomanover29.com\/blog\/transgenerational-transmission-of-aspartame-induced-anxiety-and-changes-in-glutamate-gaba-signaling-a-new-study-and-solutions\/","title":{"rendered":"Transgenerational transmission of aspartame-induced anxiety and changes in glutamate-GABA signaling: a new study and solutions"},"content":{"rendered":"

\"gaba<\/p>\n

Do you drink diet sodas or use other sugar free products that contain aspartame? Or did you when you were younger? New research has found aspartame induces anxiety and fear via changes in glutamate-GABA signaling. What is even more concerning is that these effects are transgenerational, meaning you could be living with the anxiety-provoking effects of aspartame via the diet soda habits from your father and his father\/your grandfather. This study found it impacts 2 generations via the paternal line but I suspect ongoing research may yet find impacts via your mother and grandmother too. Also, keep in mind, your current or prior use of aspartame is very likely going to impact your children and grandchildren. It’s an animal study but we don’t want to ignore yet another issue with artificial sweeteners.<\/p>\n

The good news is that we can use the amino acid GABA to help counter the high glutamate and low GABA, and ease this physical anxiety this imbalance causes. And we can use GABA and glutamine and other amino acids to break the addiction to aspartame and other artificial sweeteners.<\/p>\n

Here is the abstract of the paper – Transgenerational transmission of aspartame-induced anxiety and changes in glutamate-GABA signaling and gene expression in the amygdala<\/a><\/p>\n

We report the effects of aspartame on anxiety-like behavior, neurotransmitter signaling and gene expression in the amygdala, a brain region associated with the regulation of anxiety and fear responses. C57BL\/6 mice consumed drinking water containing 0.015% or 0.03% aspartame, a dose equivalent of 8 to 15% of the FDA recommended maximum human daily intake, or plain drinking water. Robust anxiety-like behavior (evaluated using open field test and elevated zero maze) was observed in male and female mice consuming the aspartame-containing water. Diazepam, an allosteric modulator of the GABA-A receptor, alleviated the anxiety-like behavior. RNA sequencing of the amygdala followed by KEGG biological pathway analysis of differentially expressed genes showed glutamatergic and GABAergic synapse pathways as significantly enriched. Quantitative PCR showed upregulation of mRNA for the glutamate NMDA receptor subunit 2D (Grin2d) and metabotropic receptor 4 (Grm4) and downregulation of the GABA-A receptor associated protein (Gabarap) mRNA. Thus, taken together, our diazepam and gene expression data show that aspartame consumption shifted the excitation-inhibition equilibrium in the amygdala toward excitation. Even more strikingly, the anxiety-like behavior, its response to diazepam, and changes in amygdala gene expression were transmitted to male and female offspring in two generations descending from the aspartame-exposed males. Extrapolation of the findings to humans suggests that aspartame consumption at doses below the FDA recommended maximum daily intake may produce neurobehavioral changes in aspartame-consuming individuals and their descendants. Thus, human population at risk of aspartame’s potential mental health effects may be larger than current expectations, which only include aspartame-consuming individuals.<\/p><\/blockquote>\n

A few notes to highlight:<\/p>\n