{"id":10606,"date":"2022-08-05T14:00:19","date_gmt":"2022-08-05T21:00:19","guid":{"rendered":"https:\/\/www.everywomanover29.com\/blog\/?p=10606"},"modified":"2022-09-12T14:20:24","modified_gmt":"2022-09-12T21:20:24","slug":"the-importance-of-addressing-pyroluria-with-chronic-lyme-disease-and-co-infections-mcas-mast-cell-activation-syndrome-and-other-chronic-illnesses","status":"publish","type":"post","link":"https:\/\/www.everywomanover29.com\/blog\/the-importance-of-addressing-pyroluria-with-chronic-lyme-disease-and-co-infections-mcas-mast-cell-activation-syndrome-and-other-chronic-illnesses\/","title":{"rendered":"The importance of addressing pyroluria with chronic Lyme disease (and co-infections), MCAS (Mast Cell Activation Syndrome) and other chronic illnesses"},"content":{"rendered":"

\"addressing<\/p>\n

Pyroluria is a social anxiety condition that responds well to zinc, vitamin B6, evening primrose oil and a few other key nutrients, typically resulting in resolution of social anxiety symptoms within a few weeks with the correct combination and dosing. However there is much more to pyroluria than meets the eye. Addressing this biochemical imbalance is crucial for recovery from chronic Lyme disease (and co-infections), MCAS (Mast Cell Activation Syndrome) and other chronic illnesses caused by heavy metal toxicity, mold toxicity, multiple chemical sensitivities and Ehlers Danlos syndrome (amongst others).<\/p>\n

Dr. Neil Nathan, MD, author of Toxic: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities, and Chronic Environmental Illness (2018)<\/em>, shares this about pyroluria and chronic illness:<\/p>\n

This biochemical imbalance is surprisingly common in chronically ill patients, and missing this diagnosis (by neglecting to test for and treat it) also denies us the opportunity to provide a simple, benign treatment that can help quiet down patients\u2019 already overstimulated nervous systems.<\/p><\/blockquote>\n

(Here is my Amazon link<\/a> to his book, which is excellent)<\/p>\n

For over 15 years Dr. Dietrich Klinghardt has been saying you won\u2019t see success with Lyme disease without also addressing pyroluria. He has seen a correlation with all his patients with chronic illness and pyroluria.<\/p>\n

Let me quote from an article<\/a> by Scott Forsgren, FDN-P and Dr. Dietrich Klinghardt, MD PhD: Kryptopyrroluria (aka Hemopyrrollactamuria): A Major Piece of the Puzzle in Overcoming Chronic Lyme Disease <\/em>(a Townsend letter article published in 2017):<\/p>\n

Based on testing with a lab in Holland, Klinghardt has found the incidence of KPU [Kryptopyrroluria or pyroluria] in Lyme disease to be 80% or higher; incidence of KPU over 75% in patients with heavy metal toxicity (lead, mercury, aluminum, cadmium, and others) and in children with autism over 80%.<\/p>\n

These are very significant percentages of the patient population with chronic illness that may benefit from a treatment program that addresses KPU.<\/p><\/blockquote>\n

They also state what has long been known when it comes to pyroluria: symptoms are made worse by stress and \u201cchronic infections, such as Lyme disease, may themselves serve as a trigger for the condition (of pyroluria).\u201d <\/em><\/p>\n

When it comes to MCAS, an updated version of this same article states that:<\/p>\n

Klinghardt has worked with biochemists in Germany that are beginning to link KPU with mastocytosis or mast cell activation syndrome (MCAS).<\/p>\n

They have observed that KPU treatment repairs the heme molecule, which notably stabilizes the mast cells and lowers the response to these relative rises in histamine.<\/p><\/blockquote>\n

I use the term pyroluria in this article, throughout my blog and in my book. It was coined by Carl Pfeiffer, MD PhD in the 1970s (after its discovery by Abram Hoffer in 1958). You\u2019ll see these other terms used in various articles and in some of the older research: kryptopyrroluria (KPU), hemopyrrollactamuria (HPU), pyrrole disorder, mauve factor and sometimes malvaria.<\/p>\n

As I shared in my interview with Dr. Kelly MCann on the summit, The Many Manifestations of Mast Cell Activation, it would be wonderful to get the terminology standardized and to get some case studies published. This would allow it to gain more acceptance in the mainstream and in functional medicine.<\/p>\n

These papers, Discerning the Mauve Factor, Part 1 and 2<\/a>, highlight some of the mechanisms as to why addressing pyroluria is so important:<\/p>\n